Zeitschriftenartikel: „Novel drug delivery system“

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SHARMA, PRASHANT. „Pulsatile Drug Delivery System – A Novel Approach for Time and Spatial Controlled Drug Delivery“. Journal of Pharmaceutical Technology, Research and Management 4, Nr. 1 (02.05.2016): 13–29. http://dx.doi.org/10.15415/jptrm.2016.41002.

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S, Harish, und Bhuvana K. „Niosomes: A novel drug delivery system and its Therapeutic uses“. JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES 9, Nr. 2 (15.06.2019): 31–33. http://dx.doi.org/10.58739/jcbs/v09i2.8.

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Administration of medications to specific targets with minimal affinity to other organs is a challenge during treatment of disease conditions. Drug-delivery systems which are Target-specific enable the localization of drugs to their site of action. These Targeted drug delivery systems utilize various carriers, such as serum proteins, liposomes, synthetic polymers, and microspheres. Niosomes, are a type of drug delivery system which has a bilayer structure made of non-ionic surfactants. Nio-somes are amphiphilic hence they can encapsulate both lipophilic or lipophobic drugs and increase their bioavailability. This review describes the structure, methods of preparation and applications of niosomes in various diseases. Keyword: Niosomes, Drug Delivery, Therapeutic Uses

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Ankit Kumar und Sanjeev Kumar. „Intra Vaginal Drug Delivery System (Novel Drug Delivery System)“. International Journal for Research in Applied Sciences and Biotechnology 7, Nr. 6 (26.12.2020): 234–41. http://dx.doi.org/10.31033/ijrasb.7.6.33.

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In case of intra-vaginal route of drug administration the dosage form is applied vaginally for the convenient release of the dosage form and for better therapeutic action of the medicament, it is usually used in HIV patients. many conditions that affect the female reproductive tract, such as , sexually transmitted diseases, fungal & bacterial infections, cancer and various pathogens such as virus (human immunodeficiency virus, HIV), bacteria (Gardnerella vaginalis), fungi (Candida spp.) or parasites (Trichomonas vaginalis). Systemically active drugs (contraceptive steroids) as well as locally active drugs (metronidazole Zidovudine, Lamivudine) can be effectively delivered for an extended period of time by the help of intra-vaginal controlled release system. Continuous infusion of drugs through vaginal mucosa results in the reduced possibilities of Hepatic- gastrointestinal first-pass metabolism, gastric impatience of drugs and vacillation of dosing interval. Current study focus on the, use of various polymers which are used in hydrogels, these polymers provide bioadhesive property to the vaginal formulations, so that the vaginal formulation remains on vaginal tissues for 3- 4 days. Currently available vaginal dosage forms have several limitations, such as leakage and messiness necessitating the need to develop novel drug delivery systems.

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Bhowmik, Debjit, K. P. Sampath Kumar und Lokesh Deb. „Buccal Drug Delivery System-A Novel Drug Delivery System“. Research Journal of Science and Technology 8, Nr. 2 (2016): 90. http://dx.doi.org/10.5958/2349-2988.2016.00012.7.

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Chavhan, Sarin A., Sushilkumar A. Shinde, Sandip B. Sapkal und Vinayak N. Shrikhande. „Herbal excipients in Novel Drug Delivery Systems“. International Journal of Research and Development in Pharmacy & Life Sciences 6, Nr. 3 (April 2017): 2597–605. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(3).2597-2605.

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Dhiman, Jasmine. „Novel Drug Delivery System: Brief Review“. Journal of Drug Delivery and Therapeutics 13, Nr. 11 (15.11.2023): 188–96. http://dx.doi.org/10.22270/jddt.v13i11.6023.

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Current developments in our knowledge of the pharmacokinetic and pharmacodynamics behaviour of drugs provide a more logical framework for designing the best possible drug delivery system. It is understandable that multidisciplinary efforts will play a major role in the success of drug delivery research in the future. Any therapeutic agent that has the potential to be safer, more effective, and use an enhanced drug delivery mechanism offers pharmaceutical companies significant marketing prospects as well as advancements in the treatment of illnesses. Since ancient times, humans have utilized plants as food and medicine, viewing them as nature's solutions. The underlying idea is that every sickness has a remedy that is concealed in better ways using ayurvedic, homeopathic and allopathic. However, in order to promote sustained release, improve patient compliance, etc., the way herbal medications are delivered must also be modified. Because of challenges with processing, standardizing, extracting, and identifying them, herbal medications had historically been unable to draw scientists' attention to the development of novel drug delivery methods. However, with today's technological advancements, the development of herbal revolutionary drug delivery systems is made possible by novel drug delivery systems (NDDS). It is possible to achieve protection against toxicity, stability enhancement, enhanced bioavailability, and protection against chemical and physical degradation of herbal formulations through the application of advanced procedures which must give the result in better or faster way. In this review we will get the method of preparations of NDDS and the Application of NDDS. Keywords: Herbal Drugs, Enhanced drug delivery, Phytosomes, Nanoparticles, liposomes.

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Malik, Mohit Saini Jitender K. „Novel Drug Delivery System Microsphere: A Review“. SAR Journal of Anatomy and Physiology 3, Nr. 2 (29.04.2022): 9–16. http://dx.doi.org/10.36346/sarjap.2022.v03i02.001.

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The concept of targeted drug delivery is designed to attempt to concentrate the drug in the tissues of interest while reducing the relative concentration of the drug in the remaining tissues. As a result, the drug is localized to the targeted site. Therefore, the surrounding tissues are not affected by the drug. Therefore, carrier technology provides an intelligent approach to drug delivery by coupling drugs to carrier particles such as microspheres, nanoparticles, liposomes, niosomes, etc., modulating the release and absorption characteristics drug revenue. Microspheres are typically free-flowing powders made of proteins or synthetic polymers that are biodegradable in nature and ideally have a particle size of less than 200 μm. It is a reliable way to deliver drugs to the target site with specificity, if altered, and to maintain the desired concentration at the site of interest without side effects. Microspheres have received a great deal of attention not only for sustained release but also for targeting anti-cancer drugs to tumors. In the future, by combining various strategies, microspheres will occupy a central place in the delivery of new drugs, especially in the classification of diseased cells, diagnostics, genes and genetic material, safe, targeted and effective in vivo delivery and supplements in miniature versions of diseased organs and tissues in the body.

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Sadab, Sadab, Sarad Sahu, Shubham Patel, Rubeena Khan, Basant Khare, Bhupendra Singh Thakur, Anushree Jain und Prateek Kumar Jain. „A Comprehensive Review: Transdermal Drug Delivery System: A Tool For Novel Drug Delivery System“. Asian Journal of Dental and Health Sciences 2, Nr. 4 (15.12.2022): 40–47. http://dx.doi.org/10.22270/ajdhs.v2i4.24.

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In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery and interest in life cycle management strategies among pharmaceutical companies. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through skin and into the bloodstream. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, intravenous (i.v.), intramuscular (i.m.), etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin composition offers very effective barrier that allow only small molecule based drugs to penetrate the skin and pass through the barrier. Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and more recently, it has been used for the treatment of pulmonary arterial hypertension and the enhancement of uteroplacental perfusion in case of fetal growth retardation. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variations. Keyword: Skin delivery, Transdermal drug delivery, Oral rout, Sildenafil citrate, Pulmonary arterial hypertension

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Chahar, Rajeev Kumar, Chanchal Tiwari, Princy Malik und PANKAJ KUMAR JAISWAL. „Brain-Targeted Drug Delivery System: A Novel Approach“. Journal of Drug Delivery and Therapeutics 12, Nr. 6 (15.11.2022): 171–78. http://dx.doi.org/10.22270/jddt.v12i6.5776.

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A targeted drug delivery system is based on a technique that continuously administers a predetermined dosage of a therapeutic agent to a sick location of the body. The targeted drug delivery goal is to raise the relative amount of the treatment in the target tissues while lowering it in the non-target tissues. This technique's intrinsic benefit has been reduced drug dose and adverse effects. Drug targeting in the brain is one of the most challenging issues in pharmaceutical research because the blood-brain barrier acts as an impermeable barrier for systemically delivered therapeutics and the brain extracellular matrix contributes to the poor distribution of locally delivered drugs. In the treatment of various Central nervous system (CNS) diseases, general approaches that can improve drug delivery to the brain are of great interest. Drugs are less harmful and more effective when they are administered close to where they would be most effective. Extreme research studies have recently concentrated on the development of fresh strategies for more successfully delivering medications to the brain in response to the shortcomings of the traditional delivery mechanism. This study thoroughly explains the obstacles involved in brain-targeted drug delivery, the process of drug transfer through Blood Brain Barrier, different techniques for brain-targeted drug delivery, and some recent breakthroughs in brain-targeted drug delivery. Keywords: Blood-brain barrier, Brain-targeted, Cerebrospinal fluid, Nanoparticles, Liposomes, Convection-enhanced drug delivery.

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Raj, Hans, Shagun Sharma, Ankita Sharma, Kapil Kumar Verma und Amit Chaudhary. „A Novel Drug Delivery System: Review on Microspheres“. Journal of Drug Delivery and Therapeutics 11, Nr. 2-S (15.04.2021): 156–61. http://dx.doi.org/10.22270/jddt.v11i2-s.4792.

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Microspheres are multiparticulate drug delivery systems that are designed to deliver drugs to a particular location at a fixed rate. Microspheres are free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 to 1000µm. Benefits of the use of microspheres in fields such as drug delivery, bone tissue manufacturing, and the absorption and desorption of contaminants by regeneration. The study shows the method of planning and measurement of microsphere parameters. Microspheres are complex, such as bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, radioactive microspheres. Microspheres may be used in various fields such as cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others listed in the study. In order to achieve optimal therapeutic effectiveness, it is important to deliver the agent to the target tissue at an optimum level within the right timeframe, resulting in little toxicity and minimal side effects. There are different approaches to supplying the medicinal drug to the target site in a continuous managed manner. One such strategy is the use of microspheres as drug carriers. In this article, the value of the microsphere is seen as a novel drug delivery carrier to achieve site-specific drug delivery was discussed. Keywords: microspheres, method of preparations, polymer, bioadhesion, types of microspheres

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K., Mounika, Praneetha P. und Srinivas N. „TRANSFERSOMES AS NOVEL DRUG DELIVERY SYSTEM“. International Journal of Advanced Research 11, Nr. 04 (30.04.2023): 877–81. http://dx.doi.org/10.21474/ijar01/16737.

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Transdermal drug delivery appears to be most vital drug delivery system because of its merit over conventional systems. Transferosomes & the fundamental concept of transfersomes were launched by Gregor Cevc in the year 1991. The name means carrying body and is derived from the Latin word transferre, meaning to carry across and the Greek word soma, meaning a body. Novel drug delivery system aims to deliver the drug at a rate directed by need of body during the period of treatment and channel the active entity to the site of action. Transferosome is one of the novel vesicular drug delivery system which consists of phospholipids, surfactant and water for enhanced transdermal delivery. Transferosomes are able to reach intact deeper regions of the skin after topical drug administration while delivering higher concentrations of active substances making them a successful carrier for transdermal applications. These vesicular systems can deliver low as well as high molecular weight compounds. Targeted and controlled release formulations can also be prepared by transferosomes as it can accommodate drug molecules with wide range of solubility. Various strategies can be used to augment the transdermal delivery which includes iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, & vesicular system (liposomes, niosomes, elastic liposomes such as ethosomes & transfersomes). It exists as an ultra-deformable complex having a hydrated core surrounded by a complex layer of lipid. It penetrates the stratum corneum by either intracellular route or the transcellular route by the generation of osmotic gradient. Advantages of Transferosomes are wide range of solubilities, better penetration, biocompatible and biodegradable etc. Disadvantages of Transferosomes are oxidative degradation, expensive, etc. The transfersomes were formulated by the conventional rotary evaporation sonication method. Transferosomes can be applied in controlled release, transportation of large molecular weight compounds, target delivery to peripheral subcutaneous tissues, transdermal immunization etc.

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Deori Leena Hujuri, Chinmoyee. „Artificial Intelligence (AI): It?s Role in Drug Discovery and Novel Drug Delivery System“. International Journal of Science and Research (IJSR) 13, Nr. 2 (05.02.2024): 1426–30. http://dx.doi.org/10.21275/sr24219203948.

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Antony, Dr Reena. „Improvement of Bioavailability of Valsartan through Novel Transdermal Drug Delivery System“. International Journal of Trend in Scientific Research and Development Volume-1, Issue-6 (31.10.2017): 332–38. http://dx.doi.org/10.31142/ijtsrd2508.

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Ray, Sudhir Kumar, Nargish Bano, Tripti Shukla, Neeraj Upmanyu, Sharad P. Pandey und Geeta Parkhe. „Noisomes: as novel vesicular drug delivery system“. Journal of Drug Delivery and Therapeutics 8, Nr. 6 (15.11.2018): 335–41. http://dx.doi.org/10.22270/jddt.v8i6.2029.

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various charge inducers which develop a charge on the surface of niosomes and stabilize the prepared formulation by the resulting repulsive forces. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections, microbial diseases, psoriasis, leishmaniasis, migraine, parkinson and other diseases. Niosomes can prolong the circulation of the entrapped drug in body. Encapsulation of drug in vesicular system can be predicted to prolong the existence of drug in the systemic circulation and enhance penetration into target tissue, perhaps reduce toxicity if selective uptake can be achieved. In addition to conventional, oral and parenteral routes, they are amenable to be delivered by ocular, transdermal, vaginal and inhalation routes. Delivery of biotechnological products including vaccine delivery with niosomes is also an interesting and promising research area. More concerted research efforts, however, are still required to realize the full potential of these novel systems. This review article focuses on the concept of niosomes, advantages and disadvantages, composition, method of preparation, separation of unentrapped drug, factors influencing the niosomal formulation and characterization, marketed formulations of niosomes and also gives up to date information regarding recent applications of niosomes in drug delivery. Keyword: Drug-delivery system, Niosomes,

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Nalawade, Vishwajit, und Kunal Patil. „Liposome: A Novel Drug Delivery System“. International Journal of Research Publication and Reviews 04, Nr. 01 (2022): 1795–801. http://dx.doi.org/10.55248/gengpi.2023.4148.

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Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug to its compartment and lead to controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are used for the treatment of various diseases like tumors or cancer. Liposomal Drug Delivery System and various aspects related to liposome that can be studied Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and lower toxic side effects. This review describes liposomes structure, composition, preparation methods, and evaluation clinical applications

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Ganesh, Bhatt, Raturi Ankita und Kothiyal Preeti. „Nanosuspension: A Novel Drug Delivery System“. International Journal of Pharmaceutical and Life Sciences 2, Nr. 4 (24.11.2013): 179–96. http://dx.doi.org/10.3329/ijpls.v2i4.17117.

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Low bioavailability is the major problem associated with poorly soluble drugs. The problem is more complex for drugs which are poorly soluble in both aqueous and nonaqueous media, as solubility is an essential factor for drug absorption, independent of the route of administration. Nanosuspensions have emerged as an attractive and promising approach to improve stability and bioavailability of poorly soluble drugs. These are very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1?m, without any matrix material, stabilized by surfactants and polymers. Techniques such as wet milling, high-pressure homogenization, emulsification-solvent evaporation and supercritical fluid have been used in the preparation of nanosuspension. Nanosuspension can be delivered by oral, parenteral, pulmonary and ocular routes. DOI: http://dx.doi.org/10.3329/ijpls.v2i4.17117 International Journal of Pharmaceutical and Life Sciences Volume 2, Issue 4: October 2013; 179-196

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., V. B. Kadam, K. B. Dhanawade ., V. A. Salunkhe . und A. T. Ubale A. T. . „Nanoparticle - Novel Drug Delivery System.“ Journal of Current Pharma Research 4, Nr. 4 (15.08.2014): 1318–35. http://dx.doi.org/10.33786/jcpr.2014.v04i04.009.

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Singh, Shikha Y., Smita S. Aher und Ravindra B. Saudagar. „Ethosomes –Novel Drug Delivery System“. Research Journal of Topical and Cosmetic Sciences 6, Nr. 1 (2015): 7. http://dx.doi.org/10.5958/2321-5844.2015.00002.3.

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sailaja, Abbaraju Krishna. „Aspirin Loaded Niosomes A Novel Drug Delivery System by Ether Injection Method“. Nanomedicine & Nanotechnology Open Access 8, Nr. 3 (2023): 1–5. http://dx.doi.org/10.23880/nnoa-16000237.

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Acetylsalicylic acid (ASA), generally known as aspirin, is a nonsteroidal anti-inflammatory medication (NSAID) used to treat inflammation, fever, and pain. It also has an anti-platelet action, which lowers blood clotting by reducing platelet levels and preventing heart attacks. Aspirin's common gastrointestinal side effects are stomach ulcers and bleeding. Niosomes are vesicular drug delivery system that can enhance therapeutic efficacy and minimise side effects by encapsulating aspirin into vesicles. In this study, niosomes were prepared by the ether injection method, and a total of six formulations were prepared and evaluated, of which N2 showed 98.9% drug content and 80.8% entrapment efficiency. In vitro drug release was performed, and N4 showed 45.5% drug release at 3rd hour.

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Kotta, Sabna, Navneet Sharma, Prateek Raturi, Mohd Aleem und Rakesh Kumar Sharma. „Exploring Novel Strategies for Lipid-Based Drug Delivery“. Journal of Nanotoxicology and Nanomedicine 3, Nr. 1 (Januar 2018): 1–22. http://dx.doi.org/10.4018/jnn.2018010101.

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Currently, the concept of lipid-based drug delivery systems has gained much interest because of their capability to deliver drugs which dissolve sparingly in water or insoluble in nature. Several methods of lipid-based drug delivery exist, and each method has its own advantages as well as limitations. The primary objective of the formulation development is to improve the bioavailability of the drug. The nano-sized lipid-based drug delivery systems have enough potential to do so. This article addresses the various barriers to the transportation of drugs through certain routes and also the common excipients which used to develop the lipid-based drug delivery systems. It provides a thorough overview of the lipid formulation classification scheme (LFCS) and also deals with several formulation & evaluation aspects of lipid-based drug delivery system. Further, it focuses on the formulations which are already available in the market and their regulatory concerns, respectively.

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Stockwell, Jocelyn, Nabiha Abdi, Xiaofan Lu, Oshin Maheshwari und Changiz Taghibiglou. „Novel Central Nervous System Drug Delivery Systems“. Chemical Biology & Drug Design 83, Nr. 5 (14.03.2014): 507–20. http://dx.doi.org/10.1111/cbdd.12268.

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M. Dadure, Kanhaiya, und Animeshchandra G. M. Haldar. „Cryptosomes: A Novel Promising Drug Delivery System“. International Journal of Medical & Pharmaceutical Sciences 07, Nr. 01 (2017): 01–05. http://dx.doi.org/10.31782/ijmps.2017.7101.

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Vesicular drug delivery systems might be a solution to the problem of limited bioavailability and rapid clearance of medications from the body. The four kinds of lipid-based drug delivery techniques include solid-lipid particle system, emulsion-based system, solid lipid tablet, and vesicular system. Cryptosomes are a novel vesicular drug delivery system that may solve some of the shortcomings of classic drug delivery methods, such as high stability, enhanced bioavailability, longer release, and decreased elimination of fast metabolizable drugs, among others. Cryptosome is derived from the Greek terms “Crypto,” which means “hidden,” and “Soma,” which means “body.” It’s made up of phospholipids like distearoylphosphatidylethanolamine-polyethylene glycol and distearoylphosphatidylcholine (DSPE-PEG). Vesicular systems refer to the use of vesicles as a carrier or adjuvant in a variety of applications. This research looks at several vesicular drug delivery technologies and emphasises cryptosome’s accomplishments in this area. This review will be useful to researchers working in the field of vesicular drug delivery.

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Kamboj, Anjoo. „Bexarotene: A Novel Drug Delivery System for Cutaneous T-cell Lymphoma (CTCL)“. International Journal of Psychosocial Rehabilitation 23, Nr. 4 (30.12.2019): 1786–97. http://dx.doi.org/10.37200/ijpr/v23i4/pr190509.

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Choudhary, Mahima, Chanchal Tiwari, Rajeev Kumar Chahar, Princy Malik, PANKAJ KUMAR JAISWAL und Reetu Chauhan. „Floating Drug Delivery System: As A Novel Approach for Drug Delivery“. Journal of Drug Delivery and Therapeutics 12, Nr. 6 (15.11.2022): 210–18. http://dx.doi.org/10.22270/jddt.v12i6.5778.

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The retention period of the drug and dosage form in the stomach is very challenging for the treatment of gastrointestinal disease. To solve this problem and improve the efficacy and bioavailability of the drug, most researchers develop a novel carrier system that is called a Floating drug delivery system (FDDS). The goal of this review on floating drug delivery systems (FDDS) is to synthesise contemporary material with a particular concentration on the main mechanism of flotation for stomach retention. The physiology of the stomach (including gastric pH and movement) has been shown a major effect on gastrointestinal holding period and drug delivery behaviour in both intra- and inter-subject variability. The most recent advancements in the Floating drug delivery system (FDDS) are thoroughly reviewed, including the physiological and formulation factors that influence stomach retention, design methods for single-unit and multiple-unit floating systems, and their categorization and formulation characteristics. A synopsis of the research that has been done to determine the effectiveness and utility of floating systems, as well as uses for such systems, is also included in this review. This study covers the most recent Floating drug delivery system (FDDS) technology advances, including patented delivery techniques and commercial devices, along with their benefits and potential applications for oral controlled drug administration in the future. Keywords: Floating drug delivery system, Gastric-emptying time, Inter-digestive myoelectric cycle (IDMC), Polymers, Bioavailability, Membrane permeability.

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U., Aiswarya M., Keerthana Raju, Revathy B. Menon, Lakshmi V. S. und Sreeja C. Nair. „CRYPTOSOMES: A REVOLUTIONARY BREAKTHROUGH IN NOVEL DRUG DELIVERY“. International Journal of Applied Pharmaceutics 11, Nr. 1 (09.01.2019): 7. http://dx.doi.org/10.22159/ijap.2019v11i1.29077.

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The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesicular drug delivery system which can overcome the disadvantages associated with conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolizable drugs etc. The word Cryptosome was orginated from Greek word ‘’Crypto’’ means hidden and ‘’Soma’’ means body. It is formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. These entire information regarding its origin and formation is explained in Dinesh Kumar et al. Vesicular systems symbolizes the use of vesicles in the different fields as carrier system or additives. This review disclose various vesicular drug delivery system and point out the advancement of cryptosome in the world of drug delivery.This review would help researchers involved in the field of vesicular drug delivery.

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Shep, Santosh, Sham Dodiya, Sandeep Lahoti und Rahul Mayee. „Swelling System: A Novel Approach Towards Gastroretentive Drug Delivery System“. Indo Global Journal of Pharmaceutical Sciences 01, Nr. 03 (2011): 234–42. http://dx.doi.org/10.35652/igjps.2011.23.

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Swelling Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. Swelling drug delivery systems is the system which is retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Swelling dosage systems form important technological drug delivery systems with gastric retentive behavior and offer several advantages in drug delivery. Treatment of gastrointestinal disorders such as gastro-esophageal reflux. Improved drug absorption, because of increased GRT and more time spent by the dosage form at its absorption site. Ease of administration and better patient compliance. Minimizing the mucosal irritation due to drugs, by drug releasing slowly at controlled rate. © 2011 IGJPS. All rights reserved.

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Singh, Neha, Mahesh Singh und Surbhi Panwar. „An overview of Novel Drug Delivery Systems for Acne“. International Journal of Research and Development in Pharmacy & Life Sciences 8, Nr. 4 (Oktober 2019): 1–12. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2019.8(4).1-12.

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Bansode, AS, und K. Sarvanan. „REVIEW ON NOVEL OSMOTIC DRUG DELIVERY SYSTEM“. Journal of Drug Delivery and Therapeutics 8, Nr. 5-s (15.10.2018): 87–93. http://dx.doi.org/10.22270/jddt.v8i5-s.1961.

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Novel drug delivery systems (NDDS) are the key area of pharmaceutical research and Development. The reason is relatively low development cost and time required for introducing a NDDS as compared to new chemical entity. Many conventional drug delivery systems have been designed to modulate the release a drug over an extended period of a time. Various designs are available to control or modulate the drug release from a dosage forms. Majority of oral CR dosage forms fall in the category of matrix, reservoir or osmotic systems. Osmotically controlled drug delivery systems (OCDDS) is one of the most promising drug delivery technology that use osmotic pressure as a driving force for controlled delivery of active agents. Drug release from OCDDS is independent of pH and hydrodynamic conditions of the body because of the semipermeable nature of the Rate controlling membrane and the design of deliver orifice used in osmotic systems, so a high degree of In vitro/In vivo correlation is achieved. Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT. This review brings out new technologies, fabrication and recent clinical research in osmotic drug delivery. Keywords: Osmotic, Matrix, Reservoir, Fabrication

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Shraddha Prashant Dhamapurkar und Deepa Mahendra Desai. „A review on microsphere for novel drug delivery system“. World Journal of Advanced Research and Reviews 16, Nr. 3 (30.12.2022): 529–38. http://dx.doi.org/10.30574/wjarr.2022.16.3.1368.

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Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs at tumor site. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo drug delivery and supplements as miniature versions of diseased organ and tissues in the body.

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Dave, Viny, und Ashwani Mishra. „A Review on Promising Novel Drug delivery System - Bioadhesive Drug Delivery System“. Current Research in Pharmaceutical Sciences 7, Nr. 3 (07.10.2017): 69–78. http://dx.doi.org/10.24092/crps.2017.070301.

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Pawar, Rohan. „Nose to Brain Drug Delivery System“. International Journal for Research in Applied Science and Engineering Technology 12, Nr. 3 (31.03.2024): 2412–37. http://dx.doi.org/10.22214/ijraset.2024.59316.

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Abstract: The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brainbarrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration. Intranosedelivery offers a non-invasive and convenient method to bypass the BBB and delivery of therapeutics directly to the brain. The review discusses the potential of intranoseroute to deliver drugs to the brain, the mechanisms and pathways of direct nose to brain drug transport, the various factors influencing transnosedrug absorption, the conventional and novel intranosedrug delivery systems, the various intranosedrug delivery techniques and devices, and examples of brain drug transport that have been feasible in treating various brain disorders. Moreover, products on the market, investigational drugs, and the author’s perceptions about the prospect of intranosedelivery for treating brain disorders are also been discussed.

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Singh, Anupama, Rishabha Malviya und Pramod K. Sharma. „Pulmonary Drug Delivery System: A Novel Approach for Drug Delivery“. Current Drug Therapy 6, Nr. 2 (01.05.2011): 137–51. http://dx.doi.org/10.2174/157488511795304930.

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Arpit Rajaram Suralkar, Chaitanya Shahaji Khedkar, Nidhi R Zanwar, Chanchal C Chandak und Shital J Gandhi. „Liposomes as a novel drug delivery system“. GSC Biological and Pharmaceutical Sciences 20, Nr. 3 (30.09.2022): 336–43. http://dx.doi.org/10.30574/gscbps.2022.20.3.0372.

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Liposome is a microparticulate colloidal vesicle, in which aqueous medium is surrounded by single or multiple concentric layers of phospholipids. Both hydrophilic & hydrophobic drug can be incorporated, water soluble drug being trapped in aqueous core and fat soluble drug in phospholipids. It offers controlled release, targeted drug delivery thus enhanced therapeutic efficacy and reduced dosing frequency. Several liposome based drug formulation are approved for clinical use and many are under extensive investigation. Therapeutically, these are used as carrier for drugs, viruses, bacteria, antigen, peptides (antibiotic), vaccines, genes and diagnostic agents. This review discusses about the method of production and extensive therapeutic potential of liposomes as carriers for targeted and controlled delivery.

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Kauslya, Arumugam, Payal D. Borawake, Jitendra V. Shinde und Rajashree S. Chavan. „Niosomes: A Novel Carrier Drug Delivery System“. Journal of Drug Delivery and Therapeutics 11, Nr. 1 (15.01.2021): 162–70. http://dx.doi.org/10.22270/jddt.v11i1.4479.

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Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surfactants. Niosomes are mostly preferred than liposomes because they are stable and cost effective. Niosomes potentiate the pharmacological action of the drug molecules by delaying the clearance of the drug from the circulation, protecting the drug from biological environment and restricting the effects only to the target cells. In novel drug delivery it has applications on treatment of cancer, used as a carrier in haemoglobin, delivery of the peptide drugs through oral route, in treatment of leishmaniasis, in ophthalmic delivery and as carrier in dermal drug delivery. This review article focuses on the composition, advantages, types of niosomes, methods of preparation, characterization and application of the vesicular system. Keywords: Niosomes, Composition, Types, Method of preparation, Factors affecting, Application.

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Chaudhari, Pallavi M., und Shrutika R. Randive. „Incorporated herbal drugs in novel drug delivery system“. Asian Journal of Pharmacy and Pharmacology 6, Nr. 2 (2020): 108–18. http://dx.doi.org/10.31024/ajpp.2020.6.2.3.

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Mali, Audumbar Digambar, Ritesh Bathe und Manojkumar Patil. „An updated review on transdermal drug delivery systems“. International Journal of Advances in Scientific Research 1, Nr. 6 (30.07.2015): 244. http://dx.doi.org/10.7439/ijasr.v1i6.2243.

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Transdermal drug delivery systems (TDDS), also known as patches, are dosage forms designed to deliver a therapeutically effective amount of drug across a patients skin. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation, which often causes undesirable side effects. The TDDS review articles provide valuable information regarding the transdermal drug delivery systems and its evaluation process details as a ready reference for the research scientist who is involved in TDDS. With the advancement in technology Pharma industries have trendified all its resources. Earlier we use convectional dosage form but now we use novel drug delivery system. One of greatest innovation of novel drug delivery is transdermal patch. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs.

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Bornare, Swapnil S., Smita S. Aher und Ravindranath B. Saudagar. „A REVIEW: FILM FORMING GEL NOVEL DRUG DELIVERY SYSTEM“. International Journal of Current Pharmaceutical Research 10, Nr. 2 (15.03.2018): 25. http://dx.doi.org/10.22159/ijcpr.2018v10i2.25886.

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Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments, creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) and dermal drug delivery system can provide some desirable performances over conventional pharmaceutical dosage formulations, such as avoiding gut and hepatic first-pass metabolism, improving drug bioavailability, reducing dose frequency and stabilizing drug delivery profiles. The aim of this review was to search for alternatives to the conventional forms in order to reduce skin irritation, improve skin adhesion properties, enhance the drug release and increase the patient acceptability from an aesthetic perspective. Because of their peculiar rheological behaviour, polymeric gels are beneficial in terms of ease of preparation, ease of application, adhesion to the application surface and ability to deliver a wide variety of drugs.

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Shitole, Shubham. „Nanoparticle - Novel Drug Delivery System: A Review“. International Journal for Research in Applied Science and Engineering Technology 10, Nr. 1 (31.01.2022): 517–30. http://dx.doi.org/10.22214/ijraset.2022.39849.

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Abstract: For the past few years, there has been a considerable research on the basis of Novel drug delivery system, using particulate vesicle systems as such drug carriers for small and large molecules. Nanoparticles, Liposomes, Microspheres, Niosomes, Pronisomes, Ethosomes, Proliposomes have been used as drug carrier in vesicle drug delivery system. Nanotechnology refers to the creation and utilization of materials whose constituents exist at the nanoscale; and, by convention, be up to 100 nm in size.. Nanoparticles are being used for diverse purposes, from medical treatments, using in various branches of industry production such as solar and oxide fuel batteries for energy storage, to wide incorporation into diverse materials of everyday use such as cosmetics or clothes, optical devices, catalytic, bactericidal, electronic, sensor technology, biological labelling and treatment of some cancers. Various polymers have been used in the formation of Nanoparticles. Nanoparticles have been improving the therapeutic effect of drugs and minimize the side effects. Basically, Nanoparticles have been prepared by using various techniques as such dispersion of preformed polymers, polymerization of monomers and ionic gelation or coacervation of hydrophilic polymer. Nanoparticles have been evaluated by using parameters of drug entrapment efficiency, particle shape, drug release study. Keywords: Nanoparticles, Drug, novel, delivery

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Subhi SS und S Thamrook. „Erythrocyte as novel cellular drug delivery system“. International Journal of Research in Pharmaceutical Sciences and Technology 1, Nr. 4 (30.06.2020): 151–56. http://dx.doi.org/10.33974/ijrpst.v1i4.168.

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Nowadays so many carrier systems are used for delivery of drug or any other therapeutic agent to specific tissues or cells for achieving desired therapeutic efficacy. Using drug delivery systems can improve action of therapeutic agent and reduce their toxicity. As a novel approach the erythrocyte or red blood cells are used for drug delivery. The resealed erythrocyte is a cellular carrier have more advantage than other carrier system. Based on various studies found that erythrocyte have greater potential in delivery of biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biological, antigens, anticancer drug and vaccines. The main problem obtain in case of existing carrier systems are biocompatibility of carrier and its degradation products. The biocompatibility, non-pathogenicity, non-immunogenicity and biodegradability make erythrocyte unique and useful carriers. They also possess longer circulation half-life and zero order drug release kinetics. Resealed erythrocyte carriers have certain impact among the activity of certain therapeutic agent like anti-inflammatory drugs, steroids, chemotherapeutic agents by reducing their side effect upon incorporation with these carriers. The general preparation step of resealed erythrocyte involve separation of erythrocyte from blood the organism of interest and using different methods the erythrocyte broken and the therapeutic agent or drug entrapped into the erythrocyte. This review article highlights the characteristics, isolation techniques of erythrocyte, preparation method, evaluation, application of resealed erythrocyte as carrier in drug delivery systems.

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Balwe, Manish Bandu. „Nanosponge a novel drug delivery system“. RESEARCH JOURNAL OF PHARMACEUTICAL DOSAGE FORMS AND TECHNOLOGY 12, Nr. 4 (2020): 261–66. http://dx.doi.org/10.5958/0975-4377.2020.00043.9.

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NV, Patil, Wadd NV, Thorat SS und Upadhye Shashikant Sudarshan. „Microspheres: A Novel Drug Delivery System“. American Journal of PharmTech Research 10, Nr. 2 (07.04.2020): 286–301. http://dx.doi.org/10.46624/ajptr.2020.v10.i2.021.

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Khan, AQ, T. Rana, Z. Naeem, S. Javaid, N. Sajid, A. Habib, M. Fatima und MI Khan. „Hydrogels: A Novel Drug Delivery System“. Journal of Biomedical Research & Environmental Sciences 1, Nr. 8 (24.12.2020): 439–51. http://dx.doi.org/10.37871/jbres1176.

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Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic polymers. They are made three-dimensional by the creation of the cross-links by joining them through covalent or ionic bonds. Hydrogels have been used in various areas including industry and medicine due to their excellent characteristics such as high swelling capacity, high content of water, compatibility with other biological molecules, controlled chemical and physical properties, high mechanical integrity and biodegradability. They have been the center of attention of researchers from the past 50 years because of their promising applications in industries and other areas. They are used in different fields, in medicine, in the diagnosis of the diseases, in culturing of cells, in injuries as wound healers, in cosmetics, in skin diseases like pruritis, in environmental pollution reduction and other miscellaneous applications such as in diapers for babies and sanitary products. Extensive literature can be found on the subject of hydrogels. The present review discusses the history, description of hydrogels, basic properties, classification, different techniques or methods of hydrogel synthesis and the areas in which hydrogels find applications.

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Hirlekar, Rajashree, Sunilkumar Jain, Mayank Patel, Harshal Garse und Vilasrao Kadam. „Hexosomes: A Novel Drug Delivery System“. Current Drug Delivery 7, Nr. 1 (01.01.2010): 28–35. http://dx.doi.org/10.2174/156720110790396526.

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., Ammaarah, und Krishna Sailaja A. „Liposomes – A Novel Drug Delivery System“. South Asian Research Journal of Pharmaceutical Sciences 2, Nr. 4 (09.07.2020): 58–62. http://dx.doi.org/10.36346/sarjps.2020.v02i04.001.

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Sawant, Ganesh Shankar, Kiran Vilas Sutar und Akhil S. Kanekar. „Liposome: A Novel Drug Delivery System“. International Journal of Research and Review 8, Nr. 4 (21.04.2021): 252–68. http://dx.doi.org/10.52403/ijrr.20210433.

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Liposome is a spherical sac phospholipid molecule. It encloses a water droplet especially as form artificially to carry drug into tissue membrane. It is spherical sac vesicle it consists at least one lipid bilayer. Liposomes are mainly development for drug delivery size and size distribution. The process of sonication (extrusion) is required to obtain small size and narrow size distribution of liposome. The main significant role in formulating of potent drug, improve therapeutic effect. Liposome formulation is mainly design in increasing accumulation at the target site, and then resulting effect is targeted to reduce toxicity. There is various method for liposome formulation depending upon lipid drug interaction liposome disposition mechanism- parameters particle size, charge and surface hydration. Liposome is a nanoparticle (size-100nm). Nanoscale drug delivery system using liposome as well as nanoparticle. This technology is for "Rational delivery of chemotherapeutic" drug treatment of cancer. Liposome is use as to study the cell membrane and cell organelles. The advantages of liposome formation using microfluidic approach for bulk-mixing approaches are discussed. Keywords: liposome, lipid bilayer, sonication, nanoparticles, particle size, toxicity.

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., Vrushali Tamkhane, und P. H. Sharma . „Nanosponge - A Novel Drug Delivery System“. Journal of Current Pharma Research 4, Nr. 3 (15.05.2014): 1186–93. http://dx.doi.org/10.33786/jcpr.2014.v04i03.002.

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Thenge, R. R., M. P. Chandak und V. S. Adhao. „MICROSPHERE: A NOVEL DRUG DELIVERY SYSTEM“. International Journal of Pharmacy and Technology 12, Nr. 01 (31.03.2020): 31955–73. http://dx.doi.org/10.32318/ijpt/0975-766x/12(1).31955-31973.

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Saini, Rajiv, Santosh Saini und RS Sugandha. „Biotechnology: The novel drug delivery system“. International journal of Nutrition, Pharmacology, Neurological Diseases 1, Nr. 1 (2011): 82. http://dx.doi.org/10.4103/2231-0738.77539.

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王, 继波. „Liposome—A Novel Drug Delivery System“. Hans Journal of Medicinal Chemistry 04, Nr. 03 (2016): 19–24. http://dx.doi.org/10.12677/hjmce.2016.43003.

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Matharu, Rajinder Singh, und Nalini M. Sanghavi. „Novel drug delivery system for captopril“. Drug Development and Industrial Pharmacy 18, Nr. 14 (Januar 1992): 1567–74. http://dx.doi.org/10.3109/03639049209040859.

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