Thematische Bibliographien / NIRF

Auswahl der wissenschaftlichen Literatur zum Thema „NIRF“

Autor: Grafiati
Veröffentlicht am 8. Juni 2024

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Zeitschriftenartikel zum Thema "NIRF"

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Adamczack, Julia, Martin Hoffmann, Ulrich Papke, Kristin Haufschildt, Tristan Nicke, Martin Bröring, Murat Sezer et al. „NirN Protein from Pseudomonas aeruginosa is a Novel Electron-bifurcating Dehydrogenase Catalyzing the Last Step of Heme d1 Biosynthesis“. Journal of Biological Chemistry 289, Nr. 44 (09.09.2014): 30753–62. http://dx.doi.org/10.1074/jbc.m114.603886.

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Heme d1 plays an important role in denitrification as the essential cofactor of the cytochrome cd1 nitrite reductase NirS. At present, the biosynthesis of heme d1 is only partially understood. The last step of heme d1 biosynthesis requires a so far unknown enzyme that catalyzes the introduction of a double bond into one of the propionate side chains of the tetrapyrrole yielding the corresponding acrylate side chain. In this study, we show that a Pseudomonas aeruginosa PAO1 strain lacking the NirN protein does not produce heme d1. Instead, the NirS purified from this strain contains the heme d1 precursor dihydro-heme d1 lacking the acrylic double bond, as indicated by UV-visible absorption spectroscopy and resonance Raman spectroscopy. Furthermore, the dihydro-heme d1 was extracted from purified NirS and characterized by UV-visible absorption spectroscopy and finally identified by high-resolution electrospray ionization mass spectrometry. Moreover, we show that purified NirN from P. aeruginosa binds the dihydro-heme d1 and catalyzes the introduction of the acrylic double bond in vitro. Strikingly, NirN uses an electron bifurcation mechanism for the two-electron oxidation reaction, during which one electron ends up on its heme c cofactor and the second electron reduces the substrate/product from the ferric to the ferrous state. On the basis of our results, we propose novel roles for the proteins NirN and NirF during the biosynthesis of heme d1.
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Wang, Chusi, Wenguang Peng, Jiarui Yang, Yuxuan Li, Jiawei Yang, Xueqiao Hu, Long Xia et al. „Application of near-infrared fluorescent cholangiography using indocyanine green in laparoscopic cholecystectomy“. Journal of International Medical Research 48, Nr. 12 (Dezember 2020): 030006052097922. http://dx.doi.org/10.1177/0300060520979224.

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Objective Near-infrared fluorescence cholangiography (NIRF-C) can help to identify the bile duct during laparoscopic cholecystectomy. This retrospective study was performed to investigate the effect of NIRF-C in laparoscopic cholecystectomy. Methods Consecutive patients who underwent NIRF-C-assisted laparoscopic cholecystectomy (n = 34) or conventional laparoscopic cholecystectomy (n = 36) were enrolled in this study. Identification of biliary structures, the operation time, intraoperative blood loss, and postoperative complications were analyzed. Results Laparoscopic cholecystectomy was completed in all patients without conversion to laparotomy. The median operation time and intraoperative blood loss were not significantly different between the two groups. No intraoperative injuries or postoperative complications occurred in either group. In the NIRF-C group, the visualization rate of the cystic duct, common bile duct, and common hepatic duct prior to dissection was 91%, 79%, and 53%, respectively. The success rate of cholangiography was 100% in the NIRF-C group. NIRF-C was more effective for visualizing biliary structures in patients with a BMI of <25 than >25 kg/m2. Conclusions NIRF-C is a safe and effective technique that enables real-time identification of the biliary anatomy during laparoscopic cholecystectomy. NIRF-C helps to improve the efficiency of dissection.
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Yang, Jing, Jian Yang und Chongzhao Ran. „Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation“. Contrast Media & Molecular Imaging 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/6134186.

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Recent large-scale clinical analysis indicates that brown adipose tissue (BAT) mass levels inversely correlate with body-mass index (BMI), suggesting that BAT is associated with metabolic disorders such as obesity and diabetes. PET imaging with 18F-FDG is the most commonly used method for visualizing BAT. However, this method is not able to differentiate between BAT mass and BAT activation. This task, in fact, presents a tremendous challenge with no currently existing methods to separate BAT mass and BAT activation. Our previous results indicated that BAT could be successfully imaged in mice with near infrared fluorescent (NIRF) curcumin analogues. However, the results from conventional NIRF imaging could not reflect what portion of the NIRF signal from BAT activation contributed to the signal observed. To solve this problem, we used spectral unmixing to separate/unmix NIRF signal from oil droplets in BAT, which represents its mass and NIRF signal from blood, which represents BAT activation. In this report, results from our proof-of-concept investigation demonstrated that spectral unmixing could be used to separate NIRF signal from BAT mass and BAT activation.
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Chen, Jeffrey W., Sanne Lof, Maurice J. W. Zwart, Olivier R. Busch, Freek Daams, Sebastiaan Festen, Zhi Ven Fong et al. „Intraoperative Fluorescence Imaging During Robotic Pancreatoduodenectomy to Detect Suture-Induced Hypoperfusion of the Pancreatic Stump as a Predictor of Postoperative Pancreatic Fistula (FLUOPAN): Prospective Proof-of-concept Study“. Annals of Surgery Open 4, Nr. 4 (29.11.2023): e354. http://dx.doi.org/10.1097/as9.0000000000000354.

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Background: A potential downside of robotic pancreatoduodenectomy (RPD) is the lack of tactile feedback when tying sutures, which could be especially perilous during pancreatic anastomosis. Near-infrared fluorescence imaging with indocyanine green (NIRF-ICG) could detect transpancreatic-suture-induced hypoperfusion of the pancreatic stump during RPD, which may be related to postoperative pancreatic fistula (POPF) grade B/C, but studies are lacking. Methods: This prospective study included 37 patients undergoing RPD to assess the relation between pancreatic stump hypoperfusion as objectified with NIRF-ICG using Firefly and the rate of POPF grade B/C. In 27 patients, NIRF-ICG was performed after tying down the transpancreatic U-sutures. In 10 ‘negative control’ patients, NIRF-ICG was performed before tying these sutures. Results: Pancreatic stump hypoperfusion was detected using NIRF-ICG in 9/27 patients (33%) during RPD. Hypoperfusion was associated with POPF grade B/C (67% [6/9 patients] versus 17% [3/18 patients], P = 0.026). No hypoperfusion was objectified in 10 ‘negative controls’. Conclusions: Transpancreatic-suture-induced pancreatic stump hypoperfusion can be detected using NIRF-ICG during RPD and was associated with POPF grade B/C. Surgeons could use NIRF-ICG to adapt their suturing approach during robotic pancreatico-jejunostomy. Further larger prospective studies are needed to validate the association between transpancreatic-suture-induced hypoperfusion and POPF.
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Michi, Marlies, Max Madu, Henri A. H. Winters, Daniel M. de Bruin, Joost R. van der Vorst und Caroline Driessen. „Near-Infrared Fluorescence with Indocyanine Green to Assess Bone Perfusion: A Systematic Review“. Life 12, Nr. 2 (21.01.2022): 154. http://dx.doi.org/10.3390/life12020154.

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Background: Adequate perfusion of a bone flap is essential for successful reconstruction of osseous defects. Unfortunately, complications related to inadequate bone perfusion are common. Near-infrared fluorescence (NIRF) imaging enables intraoperative visualization of perfusion. NIRF has been investigated in reconstructive surgery to aid the surgeon in clinical perioperative assessment of soft tissue perfusion. However, little is known on the beneficial use of NIRF to assess bone perfusion. Therefore, the aim of this review was to search for studies evaluating NIRF to assess bone perfusion. Methods: A systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, was performed. Studies up to October 2021 were included. We extracted data regarding the study population, size and design, reported objective fluorescence parameters and the methodology used for fluorescence imaging and processing. Results: Ten articles were included. Studies reported unevenly on the protocol used for NIRF imaging. Five studies reported objective parameters. Absolute and relative perfusion parameters and parameters derived from maximum fluorescence were reported. The clinical significance of these parameters has not been evaluated in humans. Conclusion: The evidence on bone perfusion as measured with NIRF is limited. More clinical studies are required.
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Yoshimoto, Masafumi, Aoi Tokuda, Ayami Eguchi, Yoshihiro Nozawa, Tsutomu Mori und Yuji Yaginuma. „Alterations of UHRF Family Expression and UHRF1/ICBP90 Inhibits Phosphatase and Tensin Homolog Expression in Endometrial Cancer“. Oncology 101, Nr. 7 (2023): 457–68. http://dx.doi.org/10.1159/000531209.

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<b><i>Introduction:</i></b> The altered protein expression of inverted CCAAT box-binding protein of 90 kDa/ubiquitin-like with PHD and RING finger domains 1 (ICBP90/UHRF1) and Np95-like ring finger protein (NIRF)/UHRF2, which belong to the ubiquitin-like with PHD and RING finger domains (UHRF) family, is linked to tumor malignancy and the progression of various cancers. To determine the role of NIRF and ICBP90 in endometrial tumorigenesis, we evaluated ICBP90 and NIRF expression levels in endometrial cancers. Also molecular alterations of phosphatase and tensin homolog (PTEN) expression are the important event for endometrial carcinogenesis; therefore, we investigated the involvement between ICBP90 and PTEN expression. <b><i>Methods:</i></b> We used Western blot for NIRF, ICBP90, and PTEN expression, mutation analysis of <i>NIRF</i> gene, and immunohistochemical staining for the expression of NIRF and ICBP90. For immunohistochemical staining, we examined atypical endometrial hyperplasia, endometrial cancers, and noncancerous samples. <b><i>Results:</i></b> Our data showed that the reduced expression of NIRF and overexpression of ICBP90 occurred in atypical endometrial hyperplasia and endometrial cancer compared to the normal endometrium. The decrease in NIRF expression was significantly correlated with histological grade. Expression of ICBP90 was high, especially in the peripheral margin of a cancer nest. Western blot analysis of endometrial cancer cell lines referred an opposite correlation between ICBP90 and PTEN expression. <b><i>Conclusion:</i></b> Our findings suggested that continually overexpressed ICBP90 may contribute to the inhibition of PTEN expression, which is a frequent and important event in endometrial carcinogenesis. We propose that the reduced NIRF expression and ICBP90 overexpression is an early event in endometrial carcinogenesis; thus ICBP90 may be useful as a therapeutic target in this disease.
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Xu, Huaibao, Yi Wang, Zhichao Pei, Wei Ji und Yuxin Pei. „NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery“. Chemical Communications 55, Nr. 99 (2019): 14930–33. http://dx.doi.org/10.1039/c9cc07768e.

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Al-Taher, Mahdi, Jacqueline van den Bos, Ivon Terink, Sander van Kuijk, Nehalennia van Hanegem, Nicole Bouvy, Marlies Bongers, Laurents Stassen und Arianne Lim. „Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study“. Life 12, Nr. 1 (23.12.2021): 15. http://dx.doi.org/10.3390/life12010015.

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Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy. Materials and methods: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed. Results: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05). Conclusion: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.
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Zhang, Caiqin, Yong Zhao, Ningning Zhao, Dengxu Tan, He Zhang, Xue Chen, Hai Zhang, Jiaze An, Changhong Shi und Mengbin Li. „NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye“. Contrast Media & Molecular Imaging 2018 (2018): 1–12. http://dx.doi.org/10.1155/2018/4979746.

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Combining near-infrared fluorescence (NIRF) and nuclear imaging techniques provides a novel approach for hepatocellular carcinoma (HCC) diagnosis. Here, we report the synthesis and characteristics of a dual-modality NIRF optical/positron emission tomography (PET) imaging probe using heptamethine carbocyanine dye and verify its feasibility in both nude mice and rabbits with orthotopic xenograft liver cancer. This dye, MHI-148, is an effective cancer-specific NIRF imaging agent and shows preferential uptake and retention in liver cancer. The corresponding NIRF imaging intensity reaches 109/cm2tumor area at 24 h after injection in mice with HCC subcutaneous tumors. The dye can be further conjugated with radionuclide68Ga (68Ga-MHI-148) for PET tracing. We applied the dual-modality methodology toward the detection of HCC in both patient-derived orthotopic xenograft (PDX) models and rabbit orthotopic transplantation models. NIRF/PET images showed clear tumor delineation after probe injection (MHI-148 and68Ga-MHI-148). The tumor-to-muscle (T/M) standardized uptake value (SUV) ratios were obtained from PET at 1 h after injection of68Ga-MHI-148, which was helpful for effectively capturing small tumors in mice (0.5 cm × 0.3 cm) and rabbits (1.2 cm × 1.8 cm). This cancer-targeting NIRF/PET dual-modality imaging probe provides a proof of principle for noninvasive detection of deep-tissue tumors in mouse and rabbit and is a promising technique for more accurate and early detection of HCC.
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Teranishi, Katsunori. „Evaluation of the Utilization of Near-Infrared Fluorescent Contrast Agent ASP5354 for In Vivo Ureteral Identification in Renal Diseases Using Rat Models of Gentamicin-Induced Acute Kidney Injury“. Diagnostics 13, Nr. 10 (22.05.2023): 1823. http://dx.doi.org/10.3390/diagnostics13101823.

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ASP5354 was recently developed as a near-infrared fluorescence (NIRF) contrast agent for intraoperative ureteral identification, and its use has been evaluated in healthy animals. However, the utilization of ASP5354 for ureteral identification has not been evaluated in animals with renal injury. In this study, we assessed the application of ASP5354 for ureteral imaging using rat models of gentamicin-induced mild, moderate, and severe acute kidney injury (AKI), using a clinically available NIRF detection system. NIRF was detected in the abdominal cavity and ureters after laparotomy, and the efficiency of ASP5354 was evaluated based on the NIRF signal intensity over 60 min. After the intravenous injection of ASP5354 into rats with mild or moderate AKI, the ureters were clearly imaged at a high ratio of NIRF intensity in the ureter to that in the tissues around the ureter. Six days after intravenous injection, the use of ASP5354 in rats with moderate AKI did not affect the biochemical kidney functions or histopathological conditions of the kidney tissues, as compared to those with no injection of ASP5354. In rats with severe AKI, ureteral imaging was not effective due to the relatively strong NIRF expression in the tissues around the ureters. These data indicate that ASP5354 holds potential as a contrast agent for intraoperative ureteral identification in patients with limited renal injury.
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Dissertationen zum Thema "NIRF"

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Preuß, Arne [Verfasser], und Gunhild [Akademischer Betreuer] Layer. „Biochemische Untersuchungen zu NirN und NirF aus Pseudomonas aeruginosa“. Freiburg : Universität, 2021. http://d-nb.info/1236501594/34.

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Dobroschke, Raoul Roman Götz [Verfasser]. „Untersuchung von NIRF Fluorkontrastmittel zur Detektion von Myokardinfarkten im Tiermodell / Raoul Roman Götz Dobroschke“. Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1176632043/34.

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Dobroschke, Raoul [Verfasser]. „Untersuchung von NIRF Fluorkontrastmittel zur Detektion von Myokardinfarkten im Tiermodell / Raoul Roman Götz Dobroschke“. Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1176632043/34.

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Francisco, Maira José António. „O Impacto da adoção do Plano Geral de Contabilidade : normas internacionais de relato financeiro em Moçambique“. Master's thesis, Instituto Superior de Economia e Gestão, 2016. http://hdl.handle.net/10400.5/12886.

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Mestrado em Contabilidade, Fiscalidade e Finanças Empresariais
Este estudo pretende analisar o impacto da adoção do Plano Geral de Contabilidade - Normas Internacionais de Relato Financeiro (PGC-NIRF), pelas empresas em Moçambique em 2009, nas Demonstrações Financeiras e nos principais Indicadores Económicos Financeiros. Os resultados obtidos sugerem que a alteração do normativo levou, em média, a um aumento do Capital Próprio e a uma diminuição do Resultado Líquido. As rubricas que sofreram os ajustamentos mais significativos e que contribuíram para os impactos registados foram: Ativo Intangível, Ativo Financeiros Disponíveis para Venda, Ativo por Imposto Diferido, Caixa e Equivalentes, Empréstimos, Outros Credores e Outros Passivos Correntes. Em termos de Indicadores, os mais afectados foram: Debt-to-Equity, Liquidez Geral, Liquidez Reduzida, Rendibilidade Liquida das Vendas e Rendibilidade dos Capitais Próprios.
This study aims to analyze the impact of the adoption of the General Chart of Accounts - International Financial Reporting Standards (PGC-NIRF), by companies in Mozambique in 2009, on Financial Statements and Financial Ratios. The results suggest that the adoption of the new standards increased, on average, the value of equity and decreased the value of net profit. The items that suffered the most significant adjustments and contributed to the these impacts were: Intangible Assets, Available-for-Sale Financial Assets, Deferred Tax Assets, Cash and Cash Equivalents, Loans, Other Creditors and Other Current Liabilities. The ratios most affected were: General Liquidity, Reduced Liquidity, Net Profit of Sales and Return on Equity.
N/A
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Kunick, Valentin Helmut Verfasser], und Gerhard [Akademischer Betreuer] [Adam. „Vergleichende Analyse von Nanobodies und monoklonalen Antikörpern gegen humanes CD38 für die NIRF-Bildgebung von Lymphomen in vivo / Valentin Helmut Kunick ; Betreuer: Gerhard Adam“. Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:18-105726.

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Kunick, Valentin Helmut [Verfasser], und Gerhard [Akademischer Betreuer] Adam. „Vergleichende Analyse von Nanobodies und monoklonalen Antikörpern gegen humanes CD38 für die NIRF-Bildgebung von Lymphomen in vivo / Valentin Helmut Kunick ; Betreuer: Gerhard Adam“. Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1214811957/34.

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Gennaro, Giuseppa. „Caractérisation de nifF une flavodoxine nif-spécifique chez la bactérie photosynthetique Rhodobacter capsulatus“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/NQ53281.pdf.

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Vucko, Timothé. „C-glycosides fluorés pour le marquage de peptides : Applications en imageries TEP et bimodale TEP/FPIR“. Electronic Thesis or Diss., Université de Lorraine, 2019. http://www.theses.fr/2019LORR0186.

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Les travaux développés dans cette thèse s’articulent autour de dérivés saccharidiques de type C-glycosides pour lesquels de nouvelles méthodologies synthétiques ainsi que des applications dans le domaine de l’imagerie TEP et TEP/FPIR ont été développées. Certains peptides possèdent un rôle majeur dans la thérapie et le diagnostic de diverses pathologies et le fait de les conjuguer à un dérivé saccharidique permet d’améliorer significativement leur biodistribution. La première partie de ce travail concerne la synthèse de C-glycosides fluorés (19F) et radiofluorés (18F) fonctionnalisés en position anomérique par un bras portant une fonction azide. Par réaction de cycloaddition 1,3-dipolaire, ces composés ont été couplés à des peptides dérivés de RGD, permettant ainsi le marquage de ces peptides par une méthode indirecte appelée stratégie prosthétique. La radiosynthèse d’un des radiotraceurs a été menée de manière complètement automatisée et l’évaluation biologique in vitro sur deux types d’intégrines et in vivo par imagerie TEP a pu mettre en évidence l’intérêt de ces radiotraceurs dans le domaine de l’oncologie. La seconde partie s’appuie sur ces premiers résultats concernant le développement de groupes prosthétiques saccharidiques pour aller plus loin en termes d’outils de diagnostic. L’objectif a été de mettre au point des sondes duales (radio)fluorées pour l’imagerie bimodale TEP/FPIR. Ceci a nécessité une stratégie synthétique élaborée pour introduire un atome de fluor et un fluorophore de type cyanine, tous deux étant les sondes d’imagerie spécifiques TEP et FPIR. L’accrochage d’une biomolécule (peptide RGD) a pu se faire là encore par réaction "Click". Des méthodes de fonctionnalisation régiosélectives ont permis la mise en place de ces divers éléments. Une perspective à ce travail sera d’évaluer les propriétés biologiques in vitro des outils synthétisés et de considérer cette sonde duale pour des applications diagnostique et théranostique en imagerie TEP/FPIR
The work developed in this thesis is based on saccharidic derivatives especially C-glycosides for which new synthetic methodologies and applications in the field of PET and PET/NIRF imaging have been developed. Some peptides play a major role in therapy and diagnosis of various pathologies and their conjugation with a saccharidic derivative significantly improves their biodistribution. The first part of this work concerns the synthesis of fluorinated (19F) and radiofluorinated (18F) C-glycosides fonctionalized in anomeric position by an arm bearing an azide function. These compounds were coupled by 1,3-dipolar cycloaddition to peptides derived from RGD, allowing the labeling of these peptides by an indirect method namely prosthetic strategy. The radiosynthesis of one radiotracer was fully automated. The in vitro biological evaluation on two types of integrins and in vivo by PET imaging showed the interest of these radiotracers in the field of oncology. The second part is closely linked to these first results. To go further in terms of diagnostic tools, dual (radio)fluorinated probes for bimodal PET/NIRF imaging were developed. This required an elaborated synthetic strategy to introduce a fluorine atom and a cyanine dye, both being PET and NIRF specific imaging probes. The coupling of a biomolecule (RGD peptide) was also performed by "Click" reaction. Regiocontrolled functionalization methods enabled the introduction of these various moieties. The perspective is to evaluate the in vitro biological properties of the synthetized tools and to consider this dual probe for diagnostic and theranostic applications in PET/NIRF imaging
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Ariztia, Julen. „Dérivés C-glycosidiques pour l’imagerie bimodale TEP/FPIR. Applications au marquage de dérivés peptidiques RGD“. Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0097.

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Les travaux présentés dans cette thèse concernent des dérivés saccharidiques de type C-glycosidiques pour lesquels de nouvelles méthodologies synthétiques ainsi que des applications dans le domaine de l’imagerie TEP/FPIR ont été développées. Certains peptides possèdent un rôle majeur dans la thérapie et le diagnostic de diverses pathologies, le fait de les conjuguer à un fluorophore et un radioélément permet de réaliser des diagnostics précis et d’envisager des d’applications théranostiques par chirurgie. L’objectif a été de mettre au point la synthèse de sondes duales (radio)fluorées et fluorescentes pour l’imagerie bimodale TEP/FPIR. Ceci a nécessité une stratégie synthétique élaborée pour introduire un atome de fluor et un fluorophore de type cyanine, tous deux étant les sondes d’imagerie spécifiques TEP et FPIR. Deux stratégies principales ont été développées pour la synthèse de ces outils : la fonctionnalisation d’une plate-forme de type C-glycosidique comportant un motif [3.3.0]furofuranone et la fonctionnalisation d’une plate-forme de type C-glycosidique polyhydroxylée. Les stratégies de synthèse de type protection/déprotection ont permis la mise en place de ces divers éléments suivi de la conjugaison de deux peptides dérivés du RGD par réaction "Click" de type CuAAC. L’affinité de deux dérivés divalents fluorés et fluorescents vis à vis des intégrines est du même ordre de grandeur (40 nM) que celle du peptide seul, mettant en évidence le bénéfice de la divalence de l’agent. La radiofluoration d’une sonde duale a été réalisée avec succès permettant d’envisager des applications en imagerie in vivo par TEP et FPIR ainsi qu’en chirurgie guidée par fluorescence
The work developed in this thesis deals with C-glycosyl compounds for which new synthetic methodologies and applications in PET/NIRF imaging have been developed. Some peptides have a major role in the therapy and diagnostic of diverse pathologies and their conjugation with a fluorophore and a radioelement allow precise diagnostic and potential theranostic applications by surgery. The goal was to develop the synthesis of (radio)fluorinated and fluorescent dual probes for bimodal PET/NIRF imaging. An elaborated synthetic strategy was required to introduce a fluorine atom and a cyanine-type fluorophore, both being the specific probes of PET and NIRF imaging. Two main strategies were developed for the synthesis of these tools: the functionalization of C-glycosyl derivative including a [3.3.0]furofuranone scaffold and the functionalization of polyhydroxylated C-glycosyl compound. The protection/deprotection synthetic strategies have made possible the setting up of these various elements followed by the conjugation of two peptidic RGD derivatives by CuAAC “Click” reaction. The affinity of the two fluorinated and fluorescent derivatives for the integrins was in the same range (40 nM) than the RGD peptide alone, highlighting the benefit of the divalence of the agent. The radiofluorination of a dual PET/NIRF probe have been successfully achieved, allowing application for in vivo PET and NIRF imaging as well as NIRF-guided surgery
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Wruck, Eric Michael. „Applying near-infrared spectroscopy (nirs)“. Texas A&M University, 2005. http://hdl.handle.net/1969.1/2386.

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Over recent decades, much has been learned about the perceptual capacity that enables infants to recognize and understand language. However, not until very recently have the neural mechanisms that are the substance of language learning been investigated. A recently developed optical imaging technique called near-infrared spectroscopy (NIRS) shows promise for being an acceptable alternative to invasive imaging techniques. NIRS measures correlates of neural activity by assessing hemoglobin concentration changes in the infant brain. The research presented here investigates neural activation in the left temporal and occipital cortex regions during exposure to speech and visual stimuli. As hypothesized, hemodynamic reaction was observed in both areas. Results indicate a significant activation in response to speech in the left temporal region, and an intriguing difference between uni- and bi-modally presented speech stimuli. These results have interesting implications for future multimodal studies of infant speech perception.
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Bücher zum Thema "NIRF"

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Shoḥeṭ, Nir. Niru lakhem nir!: Amarot be-khanfe milim. Tel-Aviv: Alef, 1988.

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Munūfī, ʻAmr. Niṣf ḥayāh. 8. Aufl. [Cairo?]: Dār Riwāyah lil-Nashr wa-al-Tawzīʻ, 2012.

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Azūrī, Sārah. Niṣf rajul. 8. Aufl. al-Riyāḍ: Dār al-Mufradāt lil-Nashr wa-al-Tawzīʻ, 2010.

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Moroni, Simona. Nimf: Roman. Amsterdam: Meulenhoff, 2002.

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Angola. Sistema de contabilidade em Moçambique: Plano geral de contabilidade para empresas de grande e média dimensão (PGC-NIRF); plano geral de contabilidade para as pequenas e demais empresas (PGC-PE) : aprovado pelo decreto no. 70/2009, de 22 dezembro. Maputo, Moçambique: Escolar Editora, 2009.

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Naqshabandī, Hānī. Niṣf muwāṭin muḥtaram. 8. Aufl. Bayrūt: Dār al-Sāqī, 2012.

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Nisini, Giorgio. Robert De Niro. Roma: Gremese, 2004.

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Niṣf ṣadr: Riwāyah. al-Qāhirah: al-Kutub Khān lil-Nashr wa-al-Tawzīʻ, 2014.

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Landes, Shalom. Adam ṿe-niro. Nir-ʻAm: Defus Lahav-Ḥatsor, 2003.

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Shāyib, Ibtihāl. Niṣf ḥālah: Qiṣaṣ. 8. Aufl. [Cairo?]: Dār al-Nasīm lil-Nashr wa-al-Tawzīʻ, 2013.

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Buchteile zum Thema "NIRF"

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Li, Yan, und Zhongping Chen. „Intravascular Dual-Modality Imaging (NIRF/IVUS, NIRS/IVUS, IVOCT/NIRF, and IVOCT/NIRS)“. In Multimodality Imaging, 173–89. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-10-6307-7_7.

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Prządka, Przemysław, Zdzisław Kiełbowicz und Joanna Tunikowska. „NIRF Imaging with Indocyanine Green (ICG) in a Veterinary Minimally Invasive Surgery“. In Advances in Production, 15–27. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-45021-1_2.

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Parvathi, M., und T. Amy Prasanna. „Performance Evaluation Metrics of NBA, NAAC, NIRF, and Analysis for Grade up Strategy“. In Proceedings of International Conference on Data Science and Applications, 89–107. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-6631-6_8.

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Qamar, Furqan. „Measuring Performance of Higher Education Institutions (HEIs) and the National Institutional Ranking Framework (NIRF)“. In India Higher Education Report 2017: Teaching, Learning and Quality in Higher Education, 45–87. 1 Oliver's Yard, 55 City Road London EC1Y 1SP: SAGE Publications, Inc., 2018. http://dx.doi.org/10.4135/9789353280338.n3.

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Qamar, Furqan. „Research Performance, Professional Practice, Innovation, and the National Institutional Ranking Framework (NIRF) in India“. In Academic Leadership in Higher Education in India, 110–27. London: Routledge India, 2024. http://dx.doi.org/10.4324/9781003489160-8.

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Yadav, Mamta, Arvind Bhardwaj und Kapil Kumar Goyal. „Data Analytics for NIRF Ranking of Indian Institutions to Check the Consistency and Validity of Ranking Framework“. In Lecture Notes in Mechanical Engineering, 243–55. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7059-6_19.

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Robert, Pauline, Charlotte Brault, Renaud Rincent und Vincent Segura. „Phenomic Selection: A New and Efficient Alternative to Genomic Selection“. In Methods in Molecular Biology, 397–420. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2205-6_14.

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AbstractRecently, it has been proposed to switch molecular markers to near-infrared (NIR) spectra for inferring relationships between individuals and further performing phenomic selection (PS), analogous to genomic selection (GS). The PS concept is similar to genomic-like omics-based (GLOB) selection, in which molecular markers are replaced by endophenotypes, such as metabolites or transcript levels, except that the phenomic information obtained for instance by near-infrared spectroscopy (NIRS) has usually a much lower cost than other omics. Though NIRS has been routinely used in breeding for several decades, especially to deal with end-product quality traits, its use to predict other traits of interest and further make selections is new. Since the seminal paper on PS, several publications have advocated the use of spectral acquisition (including NIRS and hyperspectral imaging) in plant breeding towards PS, potentially providing a scope of what is possible. In the present chapter, we first come back to the concept of PS as originally proposed and provide a classification of selected papers related to the use of phenomics in breeding. We further provide a review of the selected literature concerning the type of technology used, the preprocessing of the spectra, and the statistical modeling to make predictions. We discuss the factors that likely affect the efficiency of PS and compare it to GS in terms of predictive ability. Finally, we propose several prospects for future work and application of PS in the context of plant breeding.
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Oranskaia, Tatiana. „Nirl“. In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_16467-1.

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Pannu, Neesh, Xiaoyan Wen, John A. Kellum, John Fildes, N. Al-Subaie, Mark Hamilton, Susan M. Lareau et al. „NIRS“. In Encyclopedia of Intensive Care Medicine, 1548. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1952.

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Christian, Sean M., und Jess V. Ford. „NIR“. In Handbook of Near-Infrared Analysis, 95–123. 4. Aufl. Fourth edition. | Boca Raton : Taylor and Francis, 2021. |: CRC Press, 2021. http://dx.doi.org/10.1201/b22513-8.

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Konferenzberichte zum Thema "NIRF"

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Celenk, Mehmet, Lin Yang, Ganti Kamalakar, Derek J. Bleyle, Sudhir K. Sunkara, Yufei Wang, Philip Prudich, Yuangcui Huang und Qiang Zhou. „Tumor detection in vivo NIRF images“. In Medical Imaging 2004, herausgegeben von J. Michael Fitzpatrick und Milan Sonka. SPIE, 2004. http://dx.doi.org/10.1117/12.536094.

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Danskin, Tyla, Margherita Vaselli und Johannes F. de Boer. „Combined OCT-NIRF imaging for esophageal cancer detection (Conference Presentation)“. In Multimodal Biomedical Imaging XVIII, herausgegeben von Fred S. Azar, Xavier Intes und Qianqian Fang. SPIE, 2023. http://dx.doi.org/10.1117/12.2649812.

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Ghosh, Sukhen C., Barrett R. Harvey, Holly Robinson, Kenneth L. Pinkston, Nathaniel Wilganowski, Banghe Zhu, Eva M. Sevick-Muraca und Ali Azhdarinia. „Abstract 4298: Comparison of dual labeling strategies for NIRF/PET hybrid imaging“. In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4298.

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Darne, Chinmay D., und Eva M. Sevick-Muraca. „Improvements in frequency-domain based NIRF optical tomography modality for preclinical studies“. In SPIE Translational Biophotonics, herausgegeben von Tomasz S. Tkaczyk. SPIE, 2014. http://dx.doi.org/10.1117/12.2057809.

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Darne, Chinmay, Yujie Lu, I.-Chih Tan und Eva M. Sevick-Muraca. „Hybrid PET/CT and Frequency-Domain Based NIRF Optical Tomography Modality for Preclinical Studies“. In Biomedical Optics. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/biomed.2012.btu3a.70.

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Zhu, Banghe, John C. Rasmussen und Eva M. Sevick-Muraca. „Determination of detection limitation of NIRF device using QDots 800 based fluorescent solid phantom“. In Quantitative Medical Imaging. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/qmi.2013.qtu3g.4.

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Zhu, Banghe, und Eva M. Sevick-Muraca. „Development of a QDots 800 based fluorescent solid phantom for validation of NIRF imaging platforms“. In SPIE BiOS, herausgegeben von Robert J. Nordstrom. SPIE, 2013. http://dx.doi.org/10.1117/12.2002098.

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Rauschendorfer, Philipp, Andrew Thrapp, Guillermo J. Tearney und Farouc A. Jaffer. „High-speed intravascular NIRF-IVUS imaging for the assessment of atherosclerosis in coronary-sized arteries“. In Diagnostic and Therapeutic Applications of Light in Cardiology 2024, herausgegeben von Laura Marcu, Gijs van Soest und Christos Bourantas. SPIE, 2024. http://dx.doi.org/10.1117/12.3009997.

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Hettie, Kenneth S., Eben L. Rosenthal und Frederick T. Chin. „Abstract 4113: A multimodal (PET/NIRF) smart probe for selectively identifying, grading, and visualizing astrocytic gliomas“. In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4113.

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Key, Jaehong, Deepika Dhawan, Deborah K. Knapp, Kwangmeyung Kim, Ick Chan Kwon, Kuiwon Choi und James F. Leary. „Multimodal in-vivo MRI and NIRF imaging of bladder tumor using peptide conjugated glycol chitosan nanoparticles“. In SPIE BiOS, herausgegeben von Daniel L. Farkas, Dan V. Nicolau und Robert C. Leif. SPIE, 2012. http://dx.doi.org/10.1117/12.908901.

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Berichte der Organisationen zum Thema "NIRF"

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Ariza Nieto, Claudia, Olga Lucía Mayorga Mogollón, Diana Marcela Parra Forero, Deisy Bibiana Camargo Hernández, Claudia Patricia Buitrago Albarado und Jenny Milena Moreno Rodríguez. Tecnología NIRS para el análisis rápido y confiable de la composición química de forrajes tropicales. Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.plegable.2021.4.

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La espectroscopía de reflectancia en el infrarrojo cercano (NIRS, por sus siglas en inglés), es una técnica que se fundamenta en la aplicación de métodos matemáticos sobre datos químicos y, en combinación con las ondas electromagnéticas de la región del NIR (780 a 2.500 nm), se relaciona la composición química con los cambios de energía, para generar ecuaciones por cada compuesto químico, por lo tanto, la lectura espectral de una muestra es suficiente para obtener información de múltiples valores químicos relacionados con la calidad de los recursos forrajeros del trópico.
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Carpenter, J., und B. Warner. NIF facts. Office of Scientific and Technical Information (OSTI), September 2000. http://dx.doi.org/10.2172/15002091.

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Parham, T. NIF optics. Office of Scientific and Technical Information (OSTI), August 2000. http://dx.doi.org/10.2172/15002100.

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Cooper, A. B., B. A. Remington, M. W. Pound, A. S. Moore, S. A. Maclaren, R. J. Williams, D. D. Ryutov, M. E. Foord, J. C. Hayes und A. Mizuta. Eagle Nebula Experiments on NIF: NIF Facility Time Proposal. Office of Scientific and Technical Information (OSTI), Juni 2010. http://dx.doi.org/10.2172/1116954.

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Yapp, Clifford. Interactive Raytracing: The nirt Command. Fort Belvoir, VA: Defense Technical Information Center, April 2009. http://dx.doi.org/10.21236/ada499642.

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Derikx, P. J. L., B. van de Kooi, H. Heskamp und M. Rozijn. NIRS and manure composition (NIMACO). Wageningen: Wageningen Food Safety Research, 2021. http://dx.doi.org/10.18174/549611.

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Calijuri, Mónica, Gustavo A. GArcía, Juan José Bravo und José Elías Feres de Almeida. Documentos tributarios electrónicos y big data económica para el control tributario y aduanero: utilización y codificación de los estados financieros electrónicos para control fiscal y datos económico en América Latina y el Caribe: Tomo 3. Banco Interamericano de Desarrollo, Juli 2023. http://dx.doi.org/10.18235/0005000.

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El tercer tomo de la serie Documentos tributarios electrónicos y big data económica para el control tributario y aduanero analiza la implementación de los estados financieros electrónicos (EF-e) en el contexto de las Normas Internacionales de Información Financiera (NIIF) y su impacto en el control tributario por parte de las administraciones tributarias (AT). También se presentan marcos para guiar iniciativas y planes para implementar la información contable electrónica por parte de AT y gobiernos. La implementación de las NIIF ha llevado a una estandarización en los registros contables, lo que ha facilitado su digitalización y ha tenido un efecto positivo en términos de reducción de costos y mejora de la transparencia tributaria. Se propone la utilización de la tecnología de lenguaje ampliado para divulgación de informes financieros (XBRL) para estandarizar los datos financieros de las empresas, lo que no solo posibilita la integración por parte de las AT, ya que este lenguaje electrónico permite elaborar, extraer y publicar estados financieros, sino también facilita el intercambio de esta información entre las AT. Además, la implementación de los EF-e bajo las NIIF posibilita la producción de estadísticas e indicadores actualizados y detallados de la actividad económica, lo que puede contribuir al diseño de políticas públicas oportunas en beneficio de los ciudadanos.
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Carpenter, J., und B. Warner. NIF and science. Office of Scientific and Technical Information (OSTI), September 2000. http://dx.doi.org/10.2172/15002092.

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Carpenter, J., und B. Warner. NIF program management. Office of Scientific and Technical Information (OSTI), September 2000. http://dx.doi.org/10.2172/15002095.

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Young, P. E. NIF Spot Summary. Office of Scientific and Technical Information (OSTI), April 2000. http://dx.doi.org/10.2172/793864.

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