Auswahl der wissenschaftlichen Literatur zum Thema „Neuronal progenitors“

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Zeitschriftenartikel zum Thema "Neuronal progenitors"

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Shih, Hung-Yu, Chia-Wei Chang, Yi-Chieh Chen, and Yi-Chuan Cheng. "Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish." International Journal of Molecular Sciences 24, no. 2 (2023): 1733. http://dx.doi.org/10.3390/ijms24021733.

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Bone morphogenetic protein (BMP) signaling regulates neural induction, neuronal specification, and neuronal differentiation. However, the role of BMP signaling in neural progenitors remains unclear. This is because interruption of BMP signaling before or during neural induction causes severe effects on subsequent neural developmental processes. To examine the role of BMP signaling in the development of neural progenitors in zebrafish, we bypassed the effect of BMP signaling on neural induction and suppressed BMP signaling at different time points during gastrulation using a temporally controll
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Wang, D. D., D. D. Krueger, and A. Bordey. "Biophysical Properties and Ionic Signature of Neuronal Progenitors of the Postnatal Subventricular Zone In Situ." Journal of Neurophysiology 90, no. 4 (2003): 2291–302. http://dx.doi.org/10.1152/jn.01116.2002.

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Previous studies have reported the presence of neuronal progenitors in the subventricular zone (SVZ) and rostral migratory stream (RMS) of the postnatal mammalian brain. Although many studies have examined the survival and migration of progenitors after transplantation and the factors influencing their proliferation or differentiation, no information is available on the electrophysiological properties of these progenitors in a near-intact environment. Thus we performed whole cell and cell-attached patch-clamp recordings of progenitors in brain slices containing either the SVZ or the RMS from p
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Turrero García, Miguel, José-Manuel Baizabal, Diana N. Tran, et al. "Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production." Development 147, no. 22 (2020): dev187526. http://dx.doi.org/10.1242/dev.187526.

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ABSTRACTThe mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, whereas inhibitory interneurons are generated in its ventral portion. The transcriptional regulator PRDM16 is expressed by radial glia, neural progenitors present in both regions; however, its mechanisms of action are still not fully understood. It is unclear whether PRDM16 plays a similar role in neurogenesis in both dorsal and ventral progenitor lineages and, if so, whether it regulates common or uni
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Ruan, Xiangbin, Bowei Kang, Cai Qi, Wenhe Lin, Jingshu Wang, and Xiaochang Zhang. "Progenitor cell diversity in the developing mouse neocortex." Proceedings of the National Academy of Sciences 118, no. 10 (2021): e2018866118. http://dx.doi.org/10.1073/pnas.2018866118.

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In the mammalian neocortex, projection neuron types are sequentially generated by the same pool of neural progenitors. How neuron type specification is related to developmental timing remains unclear. To determine whether temporal gene expression in neural progenitors correlates with neuron type specification, we performed single-cell RNA sequencing (scRNA-Seq) analysis of the developing mouse neocortex. We uncovered neuroepithelial cell enriched genes such as Hmga2 and Ccnd1 when compared to radial glial cells (RGCs). RGCs display dynamic gene expression over time; for instance, early RGCs ex
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Findlay, Quan, Kiryu K. Yap, Annette J. Bergner, Heather M. Young, and Lincon A. Stamp. "Enteric neural progenitors are more efficient than brain-derived progenitors at generating neurons in the colon." American Journal of Physiology-Gastrointestinal and Liver Physiology 307, no. 7 (2014): G741—G748. http://dx.doi.org/10.1152/ajpgi.00225.2014.

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Gut motility disorders can result from an absent, damaged, or dysfunctional enteric nervous system (ENS). Cell therapy is an exciting prospect to treat these enteric neuropathies and restore gut motility. Previous studies have examined a variety of sources of stem/progenitor cells, but the ability of different sources of cells to generate enteric neurons has not been directly compared. It is important to identify the source of stem/progenitor cells that is best at colonizing the bowel and generating neurons following transplantation. The aim of this study was to compare the ability of central
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Nagler, Arnon, Hadar Arien-Zakay, Shimon Lecht, Hanan Galski, and Philip Lazarovici. "Nerve Growth Factor-Responsive Neuronal Progenitors From Human Umbilical Cord Blood." Blood 114, no. 22 (2009): 4601. http://dx.doi.org/10.1182/blood.v114.22.4601.4601.

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Abstract Abstract 4601 Background Nerve growth factor (NGF) is a well characterized neurotrophin required for the survival and differentiation of a variety of cell types in the peripheral and central nervous system. Over the last decade, many studies have demonstrated the physiological role of NGF in proliferation, differentiation and activation of different hematopoietic cells. Hematopoietic progenitors from bone marrow, umbilical cord blood and peripheral blood were found to be responsive to the actions of NGF. Furthermore, bone marrow stromal cells produce and respond to NGF during differen
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Antel, Jack P., Josephine Nalbantoglu, and André Olivier. "Neuronal progenitors—learning from the hippocampus." Nature Medicine 6, no. 3 (2000): 249–50. http://dx.doi.org/10.1038/73076.

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Dubreuil, V., M. Hirsch, A. Pattyn, J. Brunet, and C. Goridis. "The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity." Development 127, no. 23 (2000): 5191–201. http://dx.doi.org/10.1242/dev.127.23.5191.

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In the vertebrate neural tube, cell cycle exit of neuronal progenitors is accompanied by the expression of transcription factors that define their generic and sub-type specific properties, but how the regulation of cell cycle withdrawal intersects with that of cell fate determination is poorly understood. Here we show by both loss- and gain-of-function experiments that the neuronal-subtype-specific homeodomain transcription factor Phox2b drives progenitor cells to become post-mitotic. In the absence of Phox2b, post-mitotic neuronal precursors are not generated in proper numbers. Conversely, fo
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Mikhailov, Andrey, and Yoshiyuki Sankai. "Apoptosis in Postmortal Tissues of Goat Spinal Cords and Survival of Resident Neural Progenitors." International Journal of Molecular Sciences 25, no. 9 (2024): 4683. http://dx.doi.org/10.3390/ijms25094683.

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Growing demand for therapeutic tissue repair recurrently focusses scientists’ attention on critical assessment of postmortal collection of live cells, especially stem cells. Our study aimed to assess the survival of neuronal progenitors in postmortal spinal cord and their differentiation potential. Postmortal samples of spinal cords were obtained from human-sized animals (goats) at 6, 12, 24, 36, and 54 h after slaughter. Samples were studied by immunohistology, differentiation assay, Western blot and flow cytometry for the presence and location of GD2-positive neural progenitors and their sus
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McConnell, SK, and CE Kaznowski. "Cell cycle dependence of laminar determination in developing neocortex." Science 254, no. 5029 (1991): 282–85. http://dx.doi.org/10.1126/science.254.5029.282.

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The neocortex is patterned in layers of neurons that are generated in an orderly sequence during development. This correlation between cell birthday and laminar fate prompted an examination of how neuronal phenotypes are determined in the developing cortex. At various times after labeling with [3H]thymidine, embryonic progenitor cells were transplanted into older host brains. The laminar fate of transplanted neurons correlates with the position of their progenitors in the cell cycle at the time of transplantation. Daughters of cells transplanted in S-phase migrate to layer 2/3, as do host neur
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Dissertationen zum Thema "Neuronal progenitors"

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Hayashi, Junya. "Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain." Kyoto University, 2006. http://hdl.handle.net/2433/135623.

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Chapman, Heather M. "Gsx genes control the neuronal to glial fate switch in telencephalic progenitors." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1394725163.

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Larrosa, Madeleine Julie [Verfasser]. "The function of the zinc finger transcription factor Insm1 in neuronal progenitors / Madeleine Larrosa." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1219508306/34.

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Larrosa, Madeleine [Verfasser]. "The function of the zinc finger transcription factor Insm1 in neuronal progenitors / Madeleine Larrosa." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1219508306/34.

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Hyroššová, Petra. "Not to be picky: PEPCK-M ensures metabolic flexibility in cancer cells and neuronal progenitors." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/672607.

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Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme that catalyses decarboxylation of oxaloacetate to phosphoenolpyruvate and it is part of gluconeogenic/glyceroneogenic pathway. There are two known isoforms of PEPCK, the mitochondrial and the cytosolic isozyme that are catalysing chemically identical reactions, but they differ in regulation and expression pattern. Selective presence of mitochondrial isoform of this enzyme (PEPCK-M, PCK2) in all types of cancer examined and in cycling neuroprogenitors, suggests a functional relationship with the metabolic adaptations of these cells. This th
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WACLAW, RONALD RAYMOND. "MOLECULAR CONTROL OF NEURONAL DIVERSITY IN LATERAL GANGLIONIC EMINENCE PROGENITORS OF THE EMBRYONIC MOUSE TELENCEPHALON." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1130334258.

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Belmonte, Mateos Carla 1992. "Unveiling the molecular and behavioral properties of hindbrain rhombomere centers." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673433.

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Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment boundary-adjacent regions, hence, being absent in segment centers. This segregation of proneural gene expression therefore hints rhombomere centers as a putative non-neurogenic population. In this work, we unveil their spatiotemporal molecular profile as well as one of the mechanisms involved in their maintenance as non-committed progenitors. By 4D imaging we shed light for the first time in
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Tayel, Sara [Verfasser], Marius [Gutachter] Ader, and Frank [Gutachter] Buchholz. "Identifiying Casc15 as a novel regulator of progenitors’ proliferation and neuronal migration in the developing neocortex / Sara Tayel ; Gutachter: Marius Ader, Frank Buchholz." Dresden : Technische Universität Dresden, 2021. http://d-nb.info/123184616X/34.

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McLaughlin, Heather Ward. "Modeling sporadic Alzheimer's disease using induced pluripotent stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094355.

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Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation and neuronal cell death are well-known from the post-mortem brain tissue of Alzheimer's disease patients, but research into the earliest stages of disease development is hindered by limited model systems. In this thesis, an in vitro human neuronal system was derived from induced pluripotent stem (iPS) cell lines reprogrammed from dermal fibroblasts of AD patients and ag
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Voltes, Cobo Adrià 1991. "Hindbrain boundaries : addressing the crossroad between tissue segmentation and cell fate regulation." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665625.

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The hindbrain boundary cell population (BCP) is specified at the interface between adjacent compartments during embryonic development of the posterior brain. Hindbrain BCP is a non-neurogenic population that acts as both a signaling center and an elastic mesh that prevents cell intermingling between adjacent compartments. Remarkably, boundary cells display mechanical characteristics that emphasize the impact of tissue segmentation on boundary architecture: they display specific cell morphology and contain actomyosin cable-like structures that provide the boundaries with the tension necessary f
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Bücher zum Thema "Neuronal progenitors"

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Naglieri, Benedetta. Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis. [publisher not identified], 2012.

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The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes. Springer, 2009.

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Arturo, Álvarez-Buylla, and García-Verdugo José Manuel, eds. Identification and characterization of neural progenitor cells in the adult mammalian brain. Springer, 2009.

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Rolfs, A. Isolation and Induction of Neuronal Progenitor Cells: Rostock Spring School 2006 Contributions, Special Issue, Neurodegenerative Diseases 2007. S Karger Pub, 2007.

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Buchteile zum Thema "Neuronal progenitors"

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Zholudeva, Lyandysha V., Ying Jin, Liang Qiang, Michael A. Lane, and Itzhak Fischer. "Preparation of and Progenitors: Neuronal Production and Applications." In Neuronal Cell Culture. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1437-2_7.

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Bonner, Joseph F., Christopher J. Haas, and Itzhak Fischer. "Preparation of Neural Stem Cells and Progenitors: Neuronal Production and Grafting Applications." In Neuronal Cell Culture. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-640-5_7.

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Rex, Tonia S. "Virus-mediated Gene Delivery to Neuronal Progenitors." In Advances in Experimental Medicine and Biology. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-74904-4_16.

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Thomaidou, Dimitra, Panagiotis K. Politis, and Rebecca Matsas. "Neurogenesis in the Central Nervous System: Cell Cycle Progression/Exit and Differentiation of Neuronal Progenitors." In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60327-153-0_8.

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Alt, Frederick W., Pei-Chi Wei, and Bjoern Schwer. "Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer." In Research and Perspectives in Neurosciences. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60192-2_6.

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Horie, Nobutaka. "Neural Stem Cells/Neuronal Progenitor Cells." In Cell Therapy Against Cerebral Stroke. Springer Japan, 2017. http://dx.doi.org/10.1007/978-4-431-56059-3_3.

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Darbinyan, Armine, Rafal Kaminski, Martyn K. White, Nune Darbinian, and Kamel Khalili. "Isolation and Propagation of Primary Human and Rodent Embryonic Neural Progenitor Cells and Cortical Neurons." In Neuronal Cell Culture. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-640-5_5.

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Luskin, M. B., T. Zigova, R. Betarbet, and B. J. Soteres. "Characterization of Neuronal Progenitor Cells of the Neonatal Forebrain." In Isolation, Characterization and Utilization of CNS Stem Cells. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-80308-6_5.

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Ocasio, Jennifer Karin. "Maintaining Cerebellar Granule Neuron Progenitors in Cell Culture." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2752-5_2.

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Falls, Douglas L., and Marla B. Luskin. "Neuronal Progenitor Cells of the Mammalian Neonatal Anterior Subventricular Zone." In Neural Development and Stem Cells. Humana Press, 2006. http://dx.doi.org/10.1385/1-59259-914-1:123.

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Konferenzberichte zum Thema "Neuronal progenitors"

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Hwang, Inah, Dongqing Cao, Do-Yeon Kim, et al. "Abstract 2481: Loss of FUBP1 impairs terminal neuronal differentiation and predisposes neural progenitors for transformation." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2481.

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Lepski, Guilherme, Chary Batista, Eric Mariano, et al. "Pain Inhibition Through Transplantation of Fetal Neuronal Progenitors into the Injured Spinal Cord in Rats." In XXXII Congresso Brasileiro de Neurocirurgia. Thieme Revinter Publicações Ltda, 2018. http://dx.doi.org/10.1055/s-0038-1672636.

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Abasi, Sara, John R. Aggas, and Anthony Guiseppi-Elie. "Permissive Electroconductive Nanocomposites for Neuronal Progenitor Cells." In 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2019. http://dx.doi.org/10.1109/ner.2019.8716893.

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Safronova, N. A., T. S. Kurkin, M. B. Shevtsov, et al. "SAMPLE PREPARATION OF A RECEPTOR ASSOCIATED WITH MULTIPLE SCLEROSIS PATHOGENESIS FOR STRUCTURAL STUDIES USING CRYOELECTRON MICROSCOPY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-370.

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In this work, we study the GPCR class A receptor (rhodopsin-like) which is phylogenetically close to cysteinyl leukotriene and purine receptors. It is expressed in oligodendrocyte progenitor cells and regulates formation of the myelin sheath of neurons. To determine the structure of this receptor by cryoelectron microscopy, we created a stable and monomeric protein sample.
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Hollingsworth, Ethan, Dominic Julian, Fumihiro Watanabe, et al. "Interferome perturbation of human brain organoids induces progenitor and neuronal dysfunction seen in multiple sclerosis and autism (P2-3.015)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000204077.

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Wortham, Matthew, Genglin Jin, Julia Lailai Sun, Darell D. Bigner, and Hai Yan. "Abstract 3352: The medulloblastoma oncogene Otx2 enhances migration and permits ectopic proliferation of neuronal progenitor cells of the cerebellum and brainstem." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3352.

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Santos, Júlia Romano Ferreira, Érika Laís de Oliveira Silva, Iris Dutra Barbosa, Lorrane Silva Moura Dorneles, and Fernanda Guimarães Vieira. "REVISÃO DE LITERATURA: ASPECTOS MORFOLÓGICOS NEURONAIS CONGÊNITOS DESENCADEADOS PELA INFECÇÃO INTRA-UTERINA POR ZIKA VÍRUS." In I Congresso On-line Nacional de Histologia e Embriologia Humana. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/rems/3216.

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Introdução: Por Zika vírus (ZIKV) entende-se o patógeno arboviral pertencente ao gênero Flavivirus, notório por ser transmitido vetorialmente por artrópodes do gênero Aedes - dentre eles o Aedes aegypti - e hábil a desencadear a infecção sistêmica Zika. Foi diagnosticado documentalmente, no Brasil, em maio de 2015, por métodos biomoleculares sistematizados por pesquisadores da Universidade Federal da Bahia. O progressivo aumento das notificações relacionadas ao nascimento de crianças com microcefalia, no Nordeste, exigiu atenção do Ministério da Saúde, a fim de investigar correlações fisiopato
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Van Dyke, William S., Ozan Akkus, and Eric Nauman. "Murine Osteochondral Stem Cells Express Collagen Type I More Strongly on PDMS Substrates Than on Tissue Culture Plastic." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14272.

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The discovery of the multipotent lineage of mesenchymal stem cells has dawned a new age in tissue engineering, where an autologous cell-seeded scaffold can be implanted into different therapeutic sites. Mesenchymal stem cells have been reported to differentiate into numerous anchorage-dependent cell phenotypes, including neurons, adipocytes, myoblasts, chondrocytes, tenocytes, and osteoblasts. A seminal work detailing that mesenchymal stem cells can be directed towards differentiation of different cell types by substrate stiffness alone [1] has led to numerous studies attempting to understand
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Maire, Cecile L., Shakti H. Ramkissoon, and Keith L. Ligon. "Abstract 3304: Conditional Pten loss in Olig2 expressing neural stem/progenitor cells results in massive myelination and disruption of the neuronal differentiation in the absence of neoplasia." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3304.

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Zhang, Z., A. Lei, L. Xu, et al. "PO-277 Postmitotic neuron-like differentiation of cancer cells suggests that cancer cells have the properties of neural precursor/progenitor cells." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.308.

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Berichte der Organisationen zum Thema "Neuronal progenitors"

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Carvey, Paul M. Cytokine Induction of Dopamine Neurons from Progenitor Cells. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada391417.

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