Thematische Bibliographien / NDDs

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Auswahl der wissenschaftlichen Literatur zum Thema „NDDs“

Autor: Grafiati

Veröffentlicht am 30. Juni 2021

Zuletzt aktualisiert am 7. Februar 2022

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Zeitschriftenartikel zum Thema "NDDs"

Wang, Li, Chao-Chao Yu, Xin-Yuan Liu, Xiao-Ni Deng, Qing Tian und Yan-Jun Du. „Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases“. Neural Plasticity 2021 (29.05.2021): 1–13. http://dx.doi.org/10.1155/2021/9912686.

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Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mechanisms underlying the epigenetic regulation of microglia in NDDs. This review highlights the function and phenotypes of microglia, elucidates the relationship between microglia, epigenetic modifications, and NDDs, as well as the possible mechanisms underlying the epigenetic modulation of microglia in NDDs with a focus on potential intervention strategies.

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Sharifi-Rad, Mehdi, Chintha Lankatillake, Daniel A. Dias, Anca Oana Docea, Mohamad Fawzi Mahomoodally, Devina Lobine, Paul L. Chazot et al. „Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics“. Journal of Clinical Medicine 9, Nr. 4 (08.04.2020): 1061. http://dx.doi.org/10.3390/jcm9041061.

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Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.

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Guo, Li, Bing-Xiao Li, Mei Deng, Fang Wen, Jian-Hui Jiang, Yue-Qiu Tan, Yuan-Zong Song et al. „Etiological Analysis of Neurodevelopmental Disabilities: Single-Center Eight-Year Clinical Experience in South China“. Journal of Biomedicine and Biotechnology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/318616.

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Etiology determination of neurodevelopmental disabilities (NDDs) currently remains a worldwide common challenge on child health. We herein reported the etiology distribution feature in a cohort of 285 Chinese patients with NDDs. Although concrete NDD etiologies in 48.4% of the total patients could not be identified, genetic diseases (with the proportion of 35.8% in the total cases) including inborn errors of metabolism (IEM) and congenital dysmorphic diseases, constituted the commonest etiology category for NDDs in this study. The two key experimental technologies in pediatric metabolomics, gas chromatography-mass spectrometry (GC-MS), and tandem mass spectrometry (MS-MS), proved to be substantially helpful for the exploration of the NDD etiologies in this clinical investigation. The findings in this paper provided latest epidemiologic information on the etiology distribution of NDDs in Chinese, and the syndromic NDDs caused by citrin deficiency and the novel chromosomal karyotype, respectively, further expanded the etiology spectrum of NDDs.

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Aravamuthan, Bhooma R., Michael Shevell, Young-Min Kim, Jenny L. Wilson, Jennifer A. O'Malley, Toni S. Pearson, Michael C. Kruer et al. „Role of child neurologists and neurodevelopmentalists in the diagnosis of cerebral palsy“. Neurology 95, Nr. 21 (12.10.2020): 962–72. http://dx.doi.org/10.1212/wnl.0000000000011036.

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ObjectiveTo contextualize the role of child neurologists and neurodevelopmentalists (CNs/NDDs) in cerebral palsy (CP) care, we review the changing landscape of CP diagnosis and survey stakeholder CNs/NDDs regarding their roles in CP care.MethodsThe optimal roles of the multiple specialties involved in CP care are currently unclear, particularly regarding CP diagnosis. We developed recommendations regarding the role of CNs/NDDs noting (1) increasing complexity of CP diagnosis given a growing number of genetic etiologies and treatable motor disorders that can be misdiagnosed as CP and (2) the views of a group of physician stakeholders (CNs/NDDs from the Child Neurology Society Cerebral Palsy Special Interest Group).ResultsCNs/NDDs felt that they were optimally suited to diagnose CP. Many (76%) felt that CNs/NDDs should always be involved in CP diagnosis. However, 42% said that their patients with CP were typically not diagnosed by CNs/NDDs, and 18% did not receive referrals to establish the diagnosis of CP at all. CNs/NDDs identified areas of their expertise critical for CP diagnosis including knowledge of the neurologic examination across development and early identification of features atypical for CP. This contrasts with their views on CP management, where CNs/NDDs felt that they could contribute to the medical team, but were necessary primarily when neurologic coexisting conditions were present.DiscussionGiven its increasing complexity, we recommend early referral for CP diagnosis to a CN/NDD or specialist with comparable expertise. This contrasts with current consensus guidelines, which either do not address or do not recommend specific specialist referral for CP diagnosis.

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Berglund Melendez, Andrea, Maria Malmsten, Eva-Lena Einberg, Eva K. Clausson und Pernilla Garmy. „Supporting Students with Neurodevelopment Disorders in School Health Care—School Nurses’ Experiences“. International Journal of Environmental Research and Public Health 17, Nr. 16 (09.08.2020): 5752. http://dx.doi.org/10.3390/ijerph17165752.

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Students with neurodevelopmental disorders (NDDs) are present in every school, and most likely, there are a few students in every class. School health care is responsible for providing support to all students, especially those with special needs. The aim of the study was to describe school nurses’ experiences of supporting students with NDDs. A qualitative method consisting of seven focus group interviews (that included a total of 35 school nurses) in Southern Sweden was conducted. Three themes were identified in the findings: helping students with NDDs to interpret sensations, detecting early signs of distress among students with NDDs, and using an inclusive design for health education. This study highlights the importance of school nurses in identifying the needs of students with NDDs and promotes a person-centered approach to achieve a healthy and safe learning environment for all students.

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Soni, Neetu, Manish Ora, Girish Bathla, Chandana Nagaraj, Laura L. Boles Ponto, Michael M. Graham, Jitender Saini und Yusuf Menda. „Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions“. Neuroradiology Journal 34, Nr. 4 (05.03.2021): 263–88. http://dx.doi.org/10.1177/1971400921998968.

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Neurodegenerative diseases (NDDs) are characterized by progressive neuronal loss, leading to dementia and movement disorders. NDDs broadly include Alzheimer’s disease, frontotemporal lobar degeneration, parkinsonian syndromes, and prion diseases. There is an ever-increasing prevalence of mild cognitive impairment and dementia, with an accompanying immense economic impact, prompting efforts aimed at early identification and effective interventions. Neuroimaging is an essential tool for the early diagnosis of NDDs in both clinical and research settings. Structural, functional, and metabolic imaging modalities, including magnetic resonance imaging (MRI) and positron emission tomography (PET), are widely available. They show encouraging results for diagnosis, monitoring, and treatment response evaluation. The current review focuses on the complementary role of various imaging modalities in relation to NDDs, the qualitative and quantitative utility of newer MRI techniques, novel radiopharmaceuticals, and integrated PET/MRI in the setting of NDDs.

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Cory-Slechta, Deborah, Marissa Sobolewski und Günter Oberdörster. „Air Pollution-Related Brain Metal Dyshomeostasis as a Potential Risk Factor for Neurodevelopmental Disorders and Neurodegenerative Diseases“. Atmosphere 11, Nr. 10 (14.10.2020): 1098. http://dx.doi.org/10.3390/atmos11101098.

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Increasing evidence links air pollution (AP) exposure to effects on the central nervous system structure and function. Particulate matter AP, especially the ultrafine (nanoparticle) components, can carry numerous metal and trace element contaminants that can reach the brain in utero and after birth. Excess brain exposure to either essential or non-essential elements can result in brain dyshomeostasis, which has been implicated in both neurodevelopmental disorders (NDDs; autism spectrum disorder, schizophrenia, and attention deficit hyperactivity disorder) and neurodegenerative diseases (NDGDs; Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis). This review summarizes the current understanding of the extent to which the inhalational or intranasal instillation of metals reproduces in vivo the shared features of NDDs and NDGDs, including enlarged lateral ventricles, alterations in myelination, glutamatergic dysfunction, neuronal cell death, inflammation, microglial activation, oxidative stress, mitochondrial dysfunction, altered social behaviors, cognitive dysfunction, and impulsivity. Although evidence is limited to date, neuronal cell death, oxidative stress, and mitochondrial dysfunction are reproduced by numerous metals. Understanding the specific contribution of metals/trace elements to this neurotoxicity can guide the development of more realistic animal exposure models of human AP exposure and consequently lead to a more meaningful approach to mechanistic studies, potential intervention strategies, and regulatory requirements.

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Gupta, Swapnil, Panpan You, Tanima SenGupta, Hilde Nilsen und Kulbhushan Sharma. „Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases“. Biology 10, Nr. 2 (19.02.2021): 163. http://dx.doi.org/10.3390/biology10020163.

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Genomic integrity is maintained by DNA repair and the DNA damage response (DDR). Defects in certain DNA repair genes give rise to many rare progressive neurodegenerative diseases (NDDs), such as ocular motor ataxia, Huntington disease (HD), and spinocerebellar ataxias (SCA). Dysregulation or dysfunction of DDR is also proposed to contribute to more common NDDs, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Here, we present mechanisms that link DDR with neurodegeneration in rare NDDs caused by defects in the DDR and discuss the relevance for more common age-related neurodegenerative diseases. Moreover, we highlight recent insight into the crosstalk between the DDR and other cellular processes known to be disturbed during NDDs. We compare the strengths and limitations of established model systems to model human NDDs, ranging from C. elegans and mouse models towards advanced stem cell-based 3D models.

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Gulati, Sheffali. „Neurodevelopmental Disorders: The Journey, the Dreams and their Realization“. Annals of the National Academy of Medical Sciences (India) 53, Nr. 01 (Januar 2017): 030–35. http://dx.doi.org/10.1055/s-0040-1712742.

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ABSTRACTNeuro Developmental Disorders (NDDs) are associated with signiﬁcant morbidity. This involves early identiﬁcation of the disorder, the correct management of the disorder and associated disabilities. In India, the paucity of trained personnel and lack of knowledge about these disorders has been instrumental in inadequate management and recognition of these NDDs. The Child Neurology Division, Department of Pediatrics at All India Institute of Medical Sciences has made few noteworthy and meaningful contributions in these aspects: devising a DM curriculum for pediatric neurology, developing indigenous tools for diagnosing these NDDs and performing relevant research. These endeavors would go a long way in serving the children with NDDs.

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Ozlu, Can, Rachel M. Bailey, Sarah Sinnett und Kimberly D. Goodspeed. „Gene Transfer Therapy for Neurodevelopmental Disorders“. Developmental Neuroscience 43, Nr. 3-4 (2021): 230–40. http://dx.doi.org/10.1159/000515434.

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Neurodevelopmental disorders (NDDs) include a broad spectrum of disorders that disrupt normal brain development. Though some NDDs are caused by acquired insults (i.e., toxic or infectious encephalopathy) or may be cryptogenic, many NDDs are caused by variants in a single gene or groups of genes that disrupt neuronal development or function. In this review, we will focus on those NDDs with a genetic etiology. The exact mechanism, timing, and progression of the molecular pathology are seldom well known; however, the abnormalities in development typically manifest in similar patterns such as delays or regression in motor function, social skills, and language or cognitive abilities. Severity of impairment can vary widely. At present, only symptomatic treatments are available to manage seizures and behavioral problems commonly seen in NDDs. In recent years, there has been a rapid expansion of research into gene therapy using adeno-associated viruses (AAVs). Using AAVs as vectors to replace the non- or dysfunctional gene in vivo is a relatively simple model which has created an unprecedented opportunity for the future of NDD treatment. Advances in this field are of paramount importance as NDDs lead to a massive lifelong burden of disease on the affected individuals and families. In this article, we review the unique advantages and challenges of AAV gene therapies. We then look at potential applications of gene therapy for 3 of the more common NDDs (Rett syndrome, fragile X syndrome, and Angelman syndrome), as well as 2 less common NDDs (<i>SLC13A5</i> deficiency disorder and <i>SLC6A1</i>-related disorder). We will review the available natural history of each disease and current state of preclinical studies including a discussion on the application of AAV gene therapies for each disease.

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Dissertationen zum Thema "NDDs"

Carlström, Moa, und Vilija Kuusela. „Skolsköterskans hälsofrämjande arbete för elever med neuropsykiatriska funktionsnedsättningar : En kvalitativ intervjustudie“. Thesis, Högskolan i Skövde, Institutionen för hälsovetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20052.

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Bakgrund: Elever med neuropsykiatriska funktionsnedsättningar (NPF) är i behov av stöd då de är extra känsliga för krav och press i skolan. Skolsköterskans primära uppgift är att stärka elevens välbefinnande genom att vara närvarande, lyssna och att vara delaktig i samtal. Skolsköterskan har, tillsammans med elevhälsan, till uppgift att arbeta hälsofrämjande för att bidra till att eleven lyckas i skolan. Skolsköterskorna som träffar eleverna under hälsobesök och korta spontana besök utför ett betydelsefullt arbete för att skapa tillit och förtroende hos eleven. Syfte: Syftet var att beskriva skolsköterskans erfarenhet av hälsofrämjande insatser bland elever med NPF. Metod: Kvalitativ metod med induktiv ansats användes i studien. Semistrukturerade intervjuer genomfördes med 10 skolsköterskor. Intervjuerna analyserades i enlighet med kvalitativ innehållsanalys. Resultat: Vid analysen identifierades två kategorier: Stödjande insatser och Samarbete. Stödjande insatser inkluderar att skapa en relation via samtal och möten samt skolmiljöanpassningar. Samarbete inbegriper samverkan med andra professioner samt delaktighet med vårdnadshavare och elev. Slutsats: Ett hälsofrämjande arbete uppnås genom samverkan inom elevhälsoteamet, skolsköterskans samarbete med vårdnadshavare samt genom att göra barnen med NPF delaktiga. Dessutom bidrar skolsköterskans lyhördhet till att stärka elevernas självkänsla.
Background: Students with neurodevelopmental disorders (NDDs) need support since they are extra vulnerable for pressure and demands from school. The school nurse's primary task is to strengthen the student’s well-being by being present, listening and being involved in conversations. The school nurse, together with the student health, has the task to work with health promotion to contribute to the student’s success in school. School nurses who meet students during health visits and short spontaneous visits performs an important work to create a trustful and confident relationships. Aim: The aim was to describe the school nurse's experience of health promotion efforts among students with NDDs. Method: The study is based on a qualitative method with an inductive approach. Data collection took place through semi-structured interviews of ten school-nurses. The analysis was performed with a qualitative content analysis. Results: In the analyze, two categories emerged: Supporting initiatives and Collaboration. Supporting initiatives includes create relationship through interactions and dialogue as well as adapting the school environment. Collaboration involves cross functional cooperation as well as involvement of parents and students. Conclusion: Health promotion is achieved through cooperation within the student health team, involving parents and by making the student with NDDs a part of the process. Moreover, does the school nurse recognition contribute to strengthen the students’ self-esteem.

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Silva, Paulo Marcelo de Avellar. „Estudo da aplicação de naftaleno-diimidas para o desenvolvimento de sensores e dispositivos: eletroquimica de eletrodos modificados de carbono vítreo e compósitos com nanotubos de carbono“. Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/46/46132/tde-24082007-081716/.

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Foram sintetizadas quatro naftaleno-diimidas (NDIs) funcionalizadas com grupos N-alquil-amino e N-alquil-hidroxi. Essas espécies foram caracterizadas pelos métodos espectrométricos convencionais. As propriedades eletroquímicas destas NDIs foram estudadas por voltametria cíclica em acetonitrila e N-metil-pirrolidona. Os voltamogramas obtidos mostram dois processos redox reversíveis com E1/2 ao redor de -970 mV e de -1400 mV (vs fc/Fc+). Estes resultados são consistentes com trabalhos previamente reportados. Algumas das NDIs exibiram grande afinidade por superfícies de carbono vítreo anodizado, adsorvendo irreversivelmente. Esta propriedade foi explorada na obtenção de eletrodos modificados. As propriedades eletroquímicas de eletrodos de carbono vítreo modificados por adsorção das NDIs foram investigadas por voltametria cíclica (VC) e cronoamperometria de degrau de potencial (CADP). Os voltamogramas são caracterizados pela presença de um único processo redox reversível, com E1/2 na faixa de -360 mV a -385 mV (vs Ag/AgCl). Os transientes de CADP forneceram estimativas para as constantes de velocidade k para as reações de transferência de elétrons na superfície dos eletrodos. Foram observados desvios em relação à cinética de primeira ordem, atribuídos ao caráter micro-heterogêneo da superfície. O modelo de Albery, que considera a dispersão dos valores de k, foi aplicado e comparado com dados obtidos por ajuste de funções exponenciais. Foram também preparados compósitos à base de NDIs e nanotubos de carbono de parede simples (NTCPS) sobre eletrodos de ouro. A resposta voltamétrica dos compósitos NDI/NTCPS é caracterizada pela presença de um processo redox reversível na faixa de -336 mV a -349 mV (vs Ag/AgCl). A cinética de transferência de elétrons nestes eletrodos modificados foi estudada por metodologia análoga à descrita anteriormente. Os resultados sugerem que os eletrodos estudados podem encontrar aplicação no desenvolvimento de sensores químicos, dispositivos eletroquímicos e em eletrocatálise.
Four naphthalene-diimides (NDIs) were synthesized functionalyzed with N- alkyl-amino and N-alkyl-hydroxi groups. These NDIs were characterized by conventional spectrometric methods. The electrochemical properties of NDIs were studied through cyclic voltametry in acetonitrile and N-metyl-pyrrolidone. Typical voltammograms present two reversible redox processes with E1/2 around -970 mV and -1400 mV (vs Fc/Fc+ ). These results are consistent with previous reported works. Some NDIs showed a strong affinity to anodized glassy carbon surfaces, with irreversible adsorption. This property was used to obtain new modified glassy carbon electrodes. The electrochemical properties of glassy carbon electrodes modified by adsorption of the NDIs were studied by cyclic voltammetry (CV) and potential step chronoamperometry (PSCA). The voltammograms are characterized by the presence of a single reversible redox process, with E1/2 around -360 mV to -385 mV (vs Ag/AgCl). The PSCA transients offered estimates for the k rate constants for the electron transfer reactions on the electrode surfaces. Deviations with respect to the first order kinetics were observed and considered due to the micro-heterogeneity of the surface. Albery´s model, wich takes into account the dispersion in k values, was applied and results compared with those obtained by exponential functions fitting. Composites based on NDIs and single walled carbon nanotubes (SWNT) were also prepared on gold electrodes. The voltammetric response from NDI/SWNT composites is characterized by the presence of reversible redox process in the range from -336 mV to -349 mV (vs Ag/AgCl). The kinetics of the electron transfers on those modified electrodes was studied using a methodology similar to the one previously described. The results suggest that these modified electrodes may find application in the development of chemical sensors, electrochemical devices and in electrocatalysis.

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Scholten, Mirjam. „Semiempirische Verfahren mit Orthogonalisierungskorrekturen: die OM3-Methode“. [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967348765.

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Bouet, Jean-Yves. „Caractérisation du gène ndd du bactériophage T4. Etude de l'effet de la protéine NDD sur le nucléoi͏̈de bactérien“. Toulouse 3, 1996. http://www.theses.fr/1996TOU30139.

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Chez la bacterie escherichia coli, l'adn genomique est constitue d'une molecule circulaire de 4,6 10#6 paires de bases. Cette molecule d'adn doit etre organise pour permettre a la fois sa condensation dans la cellule et les activites transcriptionnelles et replicatives continuelles caracteristiques des procaryotes. Cependant l'organisation generale des chromosomes bacteriens est encore largement enigmatique. Les travaux presentes dans ce memoire s'inscrivent dans le cadre de l'analyse a grande echelle du nucleoide bacterien. Nous nous sommes interesse a l'etude d'un phenomene physiologique induit par le bacteriophage t4, la disruption nucleaire. En effet, en quelques minutes, le produit du gene phagique ndd est capable de detruire completement l'organisation du nucleoide. La proteine ndd pourrait donc etre un moyen d'investigation de la structure et de l'organisation du chromosome bacterien. L'introduction generale presente les donnees acquises concernant la structure et l'organisation du chromosome bacterien. Les principaux resultats obtenus au cours de ce travail sont publies. Le premier article (gene, 1994) concerne l'identification du gene ndd et sa conservation importante parmi l'ensemble de la famille des bacteriophages t-pairs. Le second article (mol. Microbiol. , 1996) presente les effets physiologiques de l'expression du gene ndd clone. Les resultats obtenus ont permis de montrer que la proteine ndd est, a elle seule, capable de provoquer le phenomene de disruption nucleaire. Cette desorganisation complete du nucleoide, accompagnee d'une importante letalite des cellules, est realise sans la moindre destruction de l'adn chromosomique. L'ensemble des resultats est consistant avec une alteration specifique d'elements structuraux du nucleoide provoquee par la proteine ndd. D'autre part, l'etude de la proteine ndd thermosensible a permis de montrer qu'elle possede, in vitro, une activite de liaison a l'adn double brin. Les donnees presentees dans ce memoire sont discutees dans le dernier chapitre. Elles confirment amplement notre hypothese d'utiliser ndd comme moyen d'investigation de la structure du chromosome bacterien

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Diksha, Khadka Pramote Prasartkul. „Abortion complications among women of reproductive age in Nepal : evidence from NDHS 2006 /“. Abstract, 2008. http://mulinet3.li.mahidol.ac.th/thesis/2551/cd419/5037965.pdf.

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Faklaris, Orestis. „Photoluminescent diamond nanoparticles as labels in cells : study of their optical properties and investigation of their cellular uptake mechanism“. Cachan, Ecole normale supérieure, 2009. http://tel.archives-ouvertes.fr/tel-00439561/fr/.

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Ce travail de thèse porte sur l'utilisation des NanoDiamants Photoluminescents (NDPs) pour des applications en bio-imagerie. Les nanodiamants (NDs) sont photoluminescents grâce à la présence de centres colorés azote-lacune (NV) dans leur maille cristalline. Le manuscrit est divisé en deux parties. La première concerne l'étude des propriétés optiques des centres colorés NV dans des NDs. Après l'optimisation de la concentration des centres NV, nous comparons la photoluminescence des NDPs à celle des nanoparticules semi-conductrices commerciales; nous concluons qu'elle peut être équivalente, même supérieure dans le cas des NDPs. Pour augmenter le contraste d'imagerie intracellulaire des NDPs, nous avons étudié l'excitation à 2-photons des centres NV. Lors de cette étude avec un laser impulsionnel, nous avons découvert que le signal de photoluminescence des NDPs excité à un photon chute très fortement lorsque l'impulsion infrarouge est simultanée de l'excitation visible. Nous avons étudié la façon d'utiliser cet effet pour l'imagerie de super-resolution. La deuxième partie porte sur l'étude des applications des NDPs comme sondes pour la bio-imagerie. Dans le but d'utiliser des NDPs comme véhicules de biomolécules, nous avons étudié leurs mécanismes d'internalisation et avons élucidé leur localisation intracellulaire, en inhibant des voies différentes d'internalisation et par des expériences d'immunofluorescence. De plus, nous avons montré que les NDPs ne sont pas toxiques pour des cellules en culture. Un premier essai de vectorisation a été mené avec de NDPs couverts d'ADN plasmidique
This thesis work studies the use of Photoluminescent NanoDiamonds (PNDs) for bio-imaging applications. Nanodiamonds are photoluminescent thanks to embedded nitrogen-vacancy (NV) color centers. The thesis is divided in two parts. The first part concerns the study of the optical properties of NV color centers in nanodiamonds. After optimization of the NV center concentration, we compared the photoluminescence of PNDs to commercial Quantum Dots (QDs) and conclude that it can be similar or even higher in the case of PNDs. To enhance the imaging contrast of internalized by cells PNDs, we studied the 2-photon excitation properties of NV centers. While implementing a pulsed excitation laser, we discovered that simultaneous one- and two-photon excitation (IR+VIS pulses) quenches the photoluminescence signal of PNDs. We examined how this effect can serve for super-resolution imaging of NV color centers in nanodiamonds. The second part of the work is devoted to the applications of PNDs as bio-imaging probes. In the prospect of applications of PNDs as drug delivery vehicles, we studied the uptake mechanisms of PNDs and elucidated their intracellular localization by blocking different entry mechanisms and by immunofluorescence experiments. Moreover, we ensured that PNDs are not toxic for cells in culture. As a first try of vectorization we covered PNDs with plasmid DNA and examined the transfection efficiency

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Baravalle, Michele. „Nationally Determined Parameters of Eurocode 2 : A Comparison among Seven European Countries“. Thesis, KTH, Bro- och stålbyggnad, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-41017.

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Since the main ambition of the European community is to create a Single Market among the European countries, a unified set of structural design codes recently became mandatory to use. These standards, the Eurocodes, contain Nationally Determined Parameters (NDPs) that have to be fixed by the National Standard Bodies in the various countries. The investigation of the adopted values for Eurocode 2 in seven European States has been carried out i this thesis for quantifying the differences that arise from the selected values of these parameters. The aim of this investigation was to find out which countries are advantaged or disadvantaged by the choice of the value of these parameters. The analysis has been limited to the Part 1-1 of Eurocode 2 that concerns “General Rules for Buildings” and the most important parts of Eurocode 0 and 1. The investigated countries were Denmark, Finland, France, Germany, Italy, Sweden and the United Kingdom. Even if these countries represent only seven out of 27 EU States, this comparison gives a good view of the European situations since they cover nearly half of the continental concrete consumption. The analysis includes a theoretical comparison of the national choices of all the 170 national parameters as well as their influence on the more important formulas contained in the Code. Five practical case studies concerning the design and the verification of some structural elements have been carried out in order to study the differences in real and common design situations. Through all the work, the different choices have been compared to the recommended values proposed by the Eurocode that have been used as a mean of comparison. Due to the large number of parameters and the complexity of the problem it has not been possible to estimate and quantify general trends of differences for the countries although Finland, France, Italy and the United Kingdom have been found to have, in general, more disadvantageous choices than the other States. Moreover, Denmark and Germany show variable trends (both above and below the recommended values) while Sweden is always close to the recommended values. The results that have been found show that still a lot of work and research has to be done in order to achieve an even set of structural standards for the design of concrete structures. A list of more important national parameters has been presented as well as a proposal to convert some national parameters to fixed ones. The analysis and the results that have been obtained give details and indications about the future works that need to be done for decreasing the differences among the European countries.

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Wang-Heaton, Hui. „A novel role of human DNA damage checkpoint protein ATR in suppressing Ca2+ overload-induced PARP1-mediated necrosis“. Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3171.

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Ataxia telangiectasia and Rad3-related (ATR) is well known for its regulatory role in DNA damage responses (DDR) as a checkpoint kinase that phosphorylates hundreds of protein substrates. However, its role in cellular non-DNA damage stress responses (NDDR) is unknown. Necrosis is one form of cell death and traditionally has been regarded as a passive and uncontrolled cell death. Recently, evidence has emerged to support the concept that necrosis also may occur in a programmed manner and that PARP1 can be a mediator. Active poly (ADP-ribose) polymerase 1 (PARP1) hydrolyzes nicotinamide adenine dinucleotide (NAD+) to produce poly (ADP-ribose) (PAR) polymers on target proteins or itself. As a result, hyper-activity of PARP1 may lead to necrosis by excessively depleting ATP pool which results in mitochondrial energetic collapse. On the other hand, it is known that Ca2+ overload induces necrosis, but much still remains unknown about how Ca2+ overload-induced necrosis is regulated in cells. In this study, we show that ATR, besides its hallmark regulatory role in DDR, also plays a role in NDDR by suppressing ionomycin-induced necrosis. Ionomycin as a Ca2+ ionophore can dramatically raise the intracellular level of Ca2+, leading to necrosis. We found that this Ca2+ overload-induced necrosis occurs without inducing DDR in cells. Instead, the hyper-poly(ADP-ribosyl)ation (PARylation) activity of activated PARP1 could be a reason leading to necrosis, as NAD+ supplied to media can rescue ionomycin-induced necrosis. In vitro PARylation assay also demonstrates that PARP1 hyper-activation is Ca2+ dependent. In cells, ATR-PARP1 interaction happened after ionomycin treatment. Furthermore, ionomycin treatment induces more full-length PAR polymers formed in ATR-deficient cells than in ATR-proficient cells. The interaction of kinase-dead ATR and PARP1 dramatically decreased as compared to wild-type ATR. Therefore, ATR plays a novel role in NDDR wherein it is able to suppress Ca2+ overload-induced PARP1-mediated necrosis. Ca2+ overload-induced cell death is a major cause of many human medical conditions and diseases, such as brain injury, stroke and ischemia et al. Our ongoing studies will help to define the molecular mechanisms of the anti-necrosis activities of ATR, which may support ATR as a new clinical target for therapeutic treatment of those diseases.

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Hervé, Nicolas. „Fluage d'aciers renforcés par dispersion nanométrique : caractérisation, modélisation et optimisation de la microstructure“. Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAI008/document.

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Dans le cadre du programme de recherche sur les matériaux de gainage pour les réacteurs à neutrons rapides au sodium, les aciers renforcés par dispersion d’oxydes (ODS) sont envisagés pour leur excellente résistance à l’irradiation et leur tenue mécanique à haute température. Néanmoins, des difficultés sont rencontrées quant à la maitrise de leur élaboration et de leur mise en forme, ainsi que sur la prédiction de leur comportement en fluage. Les travaux présentés visent à améliorer la compréhension des mécanismes de fluage d’aciers ferritiques renforcés par dispersion et à étudier les voies d’amélioration possible.Dans un premier temps, le fluage d’aciers ferritiques renforcés par dispersion obtenus par cobroyage et extrusion à été étudié grâce à deux aciers ODS à 14pd.% Cr et 18pd.%Cr, ainsi qu’un acier 18pd.%Cr renforcé par dispersion de nitrures (NDS). Une caractérisation mécanique et microstructurale (SEM – EBSD – EDX et STEM) d’éprouvettes sollicitées en fluage à respectivement 650°C et 800°C est réalisée les aciers ODS Fe18Cr et Fe14Cr. La faible déformation et la rupture brutale classiquement observée sur ce type d’acier est mise en évidence. La diminution continue de leur vitesse de déformation et l’absence d’évolutions microstructurales indiquent que le fluage se produit essentiellement dans le stade primaire. L’acier ferritique NDS a ensuite été étudié. Un phénomène de déformation superplastique (plus de 110%) a été mis en évidence à 650°C en traction entre 10-3 s-1 et 10-2 s-1, ainsi qu’une recristallisation dynamique continue au dessus de 10-2 s-1. En fluage à 650°C, l’acier NDS présente une faible déformation (moins de 1%) et une rupture brutale : il s’agit donc d’un comportement générique des aciers ferritiques renforcés par dispersion, indépendamment du type de précipité. La déformation se produisant lors du stade primaire du fluage, le comportement de ces aciers ODS et NDS a été modélisé en se basant sur l’approche de Kocks et Mecking, fondée sur l’activation thermique du glissement après franchissement des précipités par montée ou glissement dévié. Ce modèle fournit une origine physique à la contrainte seuil observée lors du fluage des aciers ODS. La déformation en fluage des deux ODS et de l’acier NDS a été simulée à partir de coefficients déterminés expérimentalement et de paramètres optimisés. Les lois de Norton, les densités de dislocation et les limites élastiques simulées sont cohérentes avec les valeurs obtenues par les essais de fluage, de traction et des mesures (STEM – EFTEM) de la densité de dislocations. Une investigation des causes de rupture brutale en fluage a ensuite été menée sur l’ODS 14pd.%Cr : grâce à un essai de fluage interrompu à 800°C alterné avec des recuits à 1050°C, la rupture brutale a été retardée et une déformation de 1.5% a été atteinte. Un suivi de l’endommagement par tomographie X et un essai de fluage après vieillissement semblent éliminer l’endommagement macroscopique et la phase σ comme cause de la rupture brutale. Un scénario basé sur une déformation critique a été proposé. Pour finir, les difficultés liées à la mise en forme des ODS ferritiques ont conduit à concevoir une nouvelle nuance ODS martensitique à 11pd.% Cr et à évaluer un nouveau procédé d’atomisation de poudres (GARS). Il apparait que la compaction directe après atomisation par la voie alternative n’améliore pas les performances de ces aciers. En revanche, après broyage, la nouvelle composition présente un potentiel intéressant en traction et en fluage à 650°C
Within the French research program for Sodium Fast Reactor (SFR) core material, oxide dispersion strengthened (ODS) steels are considered for their resistance to irradiation swelling and their good creep properties at high temperature. Their elaboration, their processing and their creep mechanism still represent challenges for material science. The aim of this work is to improve the understanding of the creep mechanisms and to investigate new fabrication route to improve these materials.First, the creep of dispersion strengthened ferritic steels produced by mechanical alloying and extrusion is studied, based on two ODS steels with 14wt.%Cr and 18wt.%Cr, and a nitride dispersion strengthened (NDS) steel with 18wt.%Cr. A microstructural (SEM-EBSD-STEM) characterization has been carried out on the two ferritic ODS steels loaded at 650°C and 800°C: a low creep strain (<0.5%) and a brutal fracture are observed. The continuous decrease of the creep rate without any microstructural change indicates a late primary stage. Then the tensile and creep behaviors of the NDS ferritic steel have been studied: a superplastic deformation, up to 110%, has been evidenced at 650°C between 10-3 s-1 and 10-2 s-1, as well as a continuous dynamic recrystallization at strain rate higher than 10-2 s-1. However, during creep tests at 650°C, the NDS steel presents the same characteristics as the ODS steels: low creep strain and brutal fracture. This behavior seems to be generic for dispersion strengthened ferritic steels obtained by mechanical alloying, regardless the type of precipitate. As the deformation occurs during the primary stage, a Kocks and Mecking model has been developed based on the thermal activation of the dislocation glide after crossing the precipitate by climb or cross-slip. This model provides a physical explanation for the threshold stress observed during the creep of ODS steels. The creep strain of the two ODS steels and the NDS steel has been simulated with experimentally determined coefficients and fitted parameters. The simulated Norton laws, dislocation density and yield stress are consistent with experimental data obtained respectively by the creep tests, by dislocation density determination (STEM-EFTEM) and tensile tests. An investigation of the creep fracture mechanisms has been performed. The creep fracture was delayed using high temperature heat treatments at 1050°C between interrupted creep tests at 800°C on the Fe14Cr ODS steel and a total elongation of 1.5% has been reached by this means. By analyzing X-ray tomography and creep test after ageing treatment, it appears that the macroscopic elongated cavities and sigma phase are not likely to explain the brutal fracture, therefore a scenario based on a critical deformation is proposed. Finally, the processing difficulties of the ferritic ODS steel lead to the design of a new martensitic 11wt. % Cr ODS steel and the evaluation of a new atomization process (GARS). This new atomization process did not improve the mechanical properties of these steels. However, after milling, encouraging results are observed since the first mechanical and microstructural characterizations displayed good tensile and creep properties

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Silva, Marina Victoretti. „Remoção de nitrogênio via Nitrificação e Desnitrificação Simultânea (NDS) em Biorreatores com Membranas Submersas (BRMS)“. reponame:Repositório Institucional da UFABC, 2016.

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Orientadora: Prof.ª Dra Luisa Helena dos Santos Oliveira
Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Ciência e Tecnologia Ambiental, 2016.
Biorreatores com Membranas Submersas (BRMS) são, atualmente, reconhecidos como opção viável para o tratamento de esgotos sanitários e o reúso de águas. Apesar disso, a tecnologia é geralmente vista como de alto investimento quando comparado a sistemas convencionais de tratamento de esgoto, sobretudo pelo maior gasto energético com aeração do sistema. Porém, BRMS quando operados sob condições específicas para nitrificação e desnitrificação simultâneas (NDS), é possível obter um efluente de elevada qualidade com menor custo, devido a menor necessidade de aeração. Nesse sentido, a operação do sistema de BRMS com o processo de NDS pode aumentar a utilização desta tecnologia no tratamento de esgoto sanitário. Neste contexto, este trabalho teve por objetivo principal avaliar a remoção de nitrogênio via NDS em diferentes concentrações de oxigênio dissolvido (OD) em uma unidade piloto de um Biorreator de Membranas Submersas tratando esgoto sanitário. Para isso, o experimento foi dividido em três Fases de acordo com a concentração de oxigênio dissolvido no licor misto: Fase I (2,3 mgO2/L), Fase II (0,8 mgO2/L e Fase III (0,3 mgO2/L). Foram alcançadas elevadas eficiências de remoção de material orgânico, independente das variações na concentração de OD, DBO5 com valores médios de 98%, 97% e 98% e DQO de 95%, 96% e 95% para as Fases I, II e III, respectivamente. A remoção média de nitrogênio total obtida foi 33% na Fase I, 60% na Fase II e 50% na Fase III. Onde a remoção via NDS foi responsável por 60%, 78% e 74% do total removido para as Fases I, II e III, respectivamente. A remoção de nitrogênio amoniacal não foi limitada devido as baixas concentrações de OD e houve acúmulo de NO2-. O sistema operou sob baixos valores de pressão transmembrana durante todo o período, porém foi encontrada diferença significativa nos valores da Fase III em relação às Fases I e II. Houve uma redução significativa na permeabilidade da membrana quando a concentração de OD no licor misto foi reduzida para 0,3 mg/L, porém sem efeito significativo quando a concentração de OD foi de 0,8 mg/L. Foram observados maiores valores de SPE ligado na Fase III em relação às demais, principalmente na fração de carboidratos que pode estar diretamente ligada a taxa de fouling. Foi possível alcançar remoção de NT em OD de 0,8 mg/L (Fase II) sem causar um impacto negativo no desempenho das membranas, sendo esta fase a mais adequada para a ocorrência do processo de NDS em BRMS.
Submerged Membrane Bioreactors (SMBR) are actually, recognized as viable option for wastewater treatment and reuse. Nevertheless, this technology is generally viewed as a high investment compared to conventional sewage treatment systems, especially for greater energy requirement for aeration system. However, SMBR when operated under specific conditions for simultaneous nitrification and denitrification (SND) it is possible to obtain a high quality effluent with lower compared to the conventional configuration because of less need for aeration. Therefore, the operation of the system SMBR with the NDS process can increase the utilization of this technology in the wastewater treatment. In this context, this study aimed to evaluate the removal of nitrogen via SND under different dissolved oxygen concentrations (DO) in a pilot of a SMBR treating wastewater. For this, the experiment was divided into three phases according to the concentration of dissolved oxygen in the mixed liquor: Phase I (2,3 mgO2/L), Phase II (0,8 mgO2/L and Phase III (0,3 mgO2/L). Were achieved high organic matter removal efficiencies regardless of fluctuations in DO concentration in terms of BOD5 average values of 98%, 97% and 98% and COD average values of 95%, 96% and 95% for Phases I, II and III respectively. The average total nitrogen removal was 33% in Phase I, 60% in Phase II and Phase III 50%. Where the removal means SND is responsible for 60%, 78% and 74% of the total removed for Phases I, II and III respectively. The removal of ammoniacal nitrogen is not limited by the low DO concentrations and there was accumulation of NO2- in Phase III. The system operated under low transmembrane pressure values throughout the period, but significant difference was found in the values of Phase III in relation to phases I and II. There was a significant reduction in membrane permeability when the DO concentration in the mixed liquor was reduced to 0.3 mg/L, but without significant effect when the DO concentration was 0.8 mg/L. It was observed highest bound EPS values in Phase III in relation to the others, mainly in the fraction of carbohydrates that can be directly linked to fouling rate. Satisfactory NT removal was achieved when concentration DO was 0.8 mg/L (Phase II) without causing a negative impact on the performance of membranes, being this phase the most suitable for the occurrence of the SND process in SMBR.

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Bücher zum Thema "NDDs"

Hughes, Jeffrey F. NDS for NT. Foster City, CA: IDG Books Worldwide, 1998.

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Minaev, B. A. NDS: Aktualʹnye voprosy. Moskva: Glavbukh, 1999.

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Andrew, Chris. Novell's NDS developer's guide. San Jose, CA: Novell Press, 1999.

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Jeffrey, Harris, Hrsg. Administering NDS corporate edition. New York: McGraw-Hill, 2000.

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Ukraine. NDS: Sbornik sistematizirovannogo zakonodatelʹstva. Kharʹkov: "Faktor", 2005.

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(Canada), NDSS Steering Committee. National Diabetes Surveillance System (NDSS) business plan. 3. Aufl. Ottawa, Ont: Health Canada, 2000.

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Konstantinov, V. N. Ischislenie NDS predprii͡a︡tii͡a︡mi razlichnykh otrasleĭ. Moskva: Glavbukh, 1998.

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Seleznev, A. P. Spravochnik platelʹshchika NDS: Zakonodatelʹnye terminy i opredelenii︠a︡, sistematizirovannyĭ ukazatelʹ osnovnykh polozheniĭ NDS, GNAU razʺi︠a︡sni︠a︡et, obzor konfliktnykh situat︠s︡iĭ, NDS i nalog na pribylʹ. Kharʹkov: "Prapor", 1998., 1998.

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Society, National Deaf Children's. Welcome to NDCS the National Deaf Children's Society. London: NDCS, 2000.

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Chatterjee, M. NDDP multi-stage flash desalination process simulator design. Mumbai: Bhabha Atomic Research Centre, 2006.

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Buchteile zum Thema "NDDs"

Akhter, Firoz, Asma Akhter und Saheem Ahmad. „Toxicity of Protein and DNA-AGEs in Neurodegenerative Diseases (NDDs) with Decisive Approaches to Stop the Deadly Consequences“. In Perspectives in Environmental Toxicology, 99–124. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46248-6_5.

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Gil’, Michael I. „Linear Autonomous NDEs“. In Atlantis Studies in Differential Equations, 159–98. Paris: Atlantis Press, 2014. http://dx.doi.org/10.2991/978-94-6239-091-1_5.

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Gil’, Michael I. „Nonlinear Vector NDEs“. In Atlantis Studies in Differential Equations, 237–61. Paris: Atlantis Press, 2014. http://dx.doi.org/10.2991/978-94-6239-091-1_7.

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Cowden, Mhairi, Claire McCullagh und Jennifer Tran. „The NDIS Trials“. In The National Disability Insurance Scheme, 79–100. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2244-1_5.

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Suski, W., und T. Palewski. „(NdS)1.23CrS2“. In Pnictides and Chalcogenides II, 812–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_216.

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Suski, W., und T. Palewski. „(NdS)1.2NbS2“. In Pnictides and Chalcogenides II, 817–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_218.

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Suski, W., und T. Palewski. „(NdS)1.16TaS2“. In Pnictides and Chalcogenides II, 801–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_212.

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Suski, W., und T. Palewski. „(NdS)1.17TaS2“. In Pnictides and Chalcogenides II, 803–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_213.

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Suski, W., und T. Palewski. „(NdS)1.18NbS2“. In Pnictides and Chalcogenides II, 808–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_215.

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Suski, W., und T. Palewski. „(NdS)1.23VS2“. In Pnictides and Chalcogenides II, 815–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/10713485_217.

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Konferenzberichte zum Thema "NDDs"

„nDS 2007“. In 2007 International Workshop on Multidimensional (nD) Systems. IEEE, 2007. http://dx.doi.org/10.1109/nds.2007.4509524.

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„nDS 2007 Committees“. In 2007 International Workshop on Multidimensional (nD) Systems. IEEE, 2007. http://dx.doi.org/10.1109/nds.2007.4509529.

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Invernizzi, Diletta Colette, Giorgio Locatelli, Naomi J. Brookes und Martin Grey. „Similar but Different: A Top-Down Benchmarking Approach to Investigate Nuclear Decommissioning Projects“. In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66155.

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Project management literature has, until now, mainly focused on new build and only in the last decades the issues of decommissioning (mega) projects has arisen. To respond to this changing environment, project management will need to understand the challenges of decommissioning projects. Decommissioning projects within Oil & Gas, Chemical and Nuclear sectors are characterized by high costs, long schedules and uncertainty-based risks. The budget for Nuclear Decommissioning Projects and Programmes (NDPs) are subject to well publicized increases and, due to their relatively recent emergence, complexity and variety, key stakeholders lack a full understanding of the key factors influencing these increases. Benchmarking involves “comparing actual or planned practices [...] to identify best practices, generate ideas for improvement” [1] and offers significant potential to improve the performance of project selection, planning and delivery. However, even if benchmarking is the envisaged methodology to investigate the NDPs characteristics that impact on the NDPs performance, until now, it has only been partially used and there is a huge gap in the literature concerning benchmarking NDPs. This paper adapts a top-down benchmarking approach to highlight the NDPs characteristics that mostly impact on the NDPs performance. This is exemplified by a systematic quantitative and qualitative cross-comparison of two major “similar-but-different” NDPs: Rocky Flats (US) and Sellafield (UK). Main results concern the understanding of the alternatives of the owner and/or the contractors in relation to (1) the physical characteristics and the end state of the nuclear site, (2) the governance, funding & contracting schemes, and (3) the stakeholders’ engagement.

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Chen, Shuo, Junwei Cao und Lipeng Zhu. „NDSS: A Named Data Storage System“. In 2015 International Conference on Cloud and Autonomic Computing (ICCAC). IEEE, 2015. http://dx.doi.org/10.1109/iccac.2015.12.

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Wang, Hengyu, Min Zou, Robert L. Jackson, Preston R. Larson und Matthew B. Johnson. „Nanoindentation on a Ni Nanodot-Patterned Surface“. In 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2008. http://dx.doi.org/10.1115/micronano2008-70147.

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Nanoindentation on a Ni nanodot-patterned surface (NDPS) was investigated experimentally and numerically. The Ni NDPS consists of well-ordered arrays of Ni nanodots with approximately the same size and shape. The nanoindentation experiments were performed on the Ni NDPS using diamond tips of 1 and 5 μm radii of curvature. To efficiently simulate large number of nanodots in contact, numerical simulations were carried out using formulae empirically fitted from a finite element (FE) study of a single spherical contact. The simulation results were found to be in good agreement with the experimental results.

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Invernizzi, Diletta Colette, Giorgio Locatelli und Naomi J. Brookes. „Applying Statistics to Improve the Performance of Nuclear Decommissioning Projects“. In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81428.

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Nuclear Decommissioning Projects and Programmes (NDPs) are characterized by significant risks, long schedules, and high costs that keep rising. Additionally, due to the NDP complexity and variety, it is extremely hard to understand which are the NDP characteristics that are associated with the NDP performance. This research takes the project management perspective, collects empirical information on NDPs and investigates this relationship between NDP characteristics and NDP performance, both through qualitative cross-comparison and quantitative statistical analysis based on the Fisher’s Exact Test (FET). In this paper, the results from the implementation of the FET applied on a pool of European NDPs are presented and discussed. Key takeaways are that some project characteristics present a stronger relationship with the project performance, while others do not show a significant association. Ultimately, qualitative and quantitative analyses complement each other to support the development of guidelines and improve the selection, planning and delivery of future NDPs.

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Yuping, Han, Zhu Ligu, Zhang Lei und Zhang Ruisong. „NDVS: A System of News Data Visualize“. In 2015 Fifth International Conference on Instrumentation & Measurement, Computer, Communication and Control (IMCCC). IEEE, 2015. http://dx.doi.org/10.1109/imccc.2015.106.

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Zhang, Xingyu, Qingpu Wang, Shengzhi Zhao, Lianke Sun und Shaojun Zhang. „Mode-locked characteristics of Nd:S-VAP crystal“. In Photonics West '97, herausgegeben von Richard Scheps. SPIE, 1997. http://dx.doi.org/10.1117/12.269995.

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Arai, Kensaku, Jinya Katsuyama und Yinsheng Li. „Sensitivity Study on the Effects of Nondestructive Examinations on Failure Probabilities of Reactor Pressure Vessels“. In ASME 2018 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/pvp2018-84989.

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Reactor pressure vessels (RPVs) in nuclear power plants are important components that prevent non-ductile fracture considering neutron irradiation embrittlement as aging degradation and several types of transients. An analysis code called PASCAL for assessing failure frequencies of RPVs based on probabilistic fracture mechanics has been developed by the Japan Atomic Energy Agency. In failure frequency analyses, flaw size distribution in RPVs is one of the most important parameters, and it is determined by considering possible flaws generated during fabrication and the flaw-detection capabilities of nondestructive examinations (NDEs). Flaw-detection capabilities of NDEs are represented as probability of detection (POD) curves related to flaw sizes. In this study, the effects of NDEs on failure frequencies of RPVs are evaluated using PASCAL considering simplified POD curves in terms of minimum detectable flaw size, the smallest probability of non-detection (PND), and flaw size where POD value reaches the smallest PND.

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Chen, Shin-Shung, Tzong-Yih Kuo und Yu-Wen Chen. „Security Software Based on Windows NDIS Filter Drivers“. In 2013 IEEE 37th International Computer Software and Applications Conference Workshops (COMPSACW). IEEE, 2013. http://dx.doi.org/10.1109/compsacw.2013.36.

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Berichte der Organisationen zum Thema "NDDs"

Schempf, H. RoboCon: Operator interface for robotic applications. Final report: RoboCon electrical interfacing -- system architecture, and Interfacing NDDS and LabView. Office of Scientific and Technical Information (OSTI), April 1998. http://dx.doi.org/10.2172/674604.

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Childress, Sam, John Doe, Andrew Jackson, Steven Weinberg, George Bush, Edwin McMillan, Steven Chu und Robert Aymar. NOvA Near Detector On the Surface (NDOS). Office of Scientific and Technical Information (OSTI), Februar 2011. http://dx.doi.org/10.2172/1296761.

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Jones, Natalie, Miquel Muñoz Cabré, Georgia Piggot und Michael Lazarus. Tapping the potential of NDCs and LT-LEDS to address fossil fuel production. Stockholm Environment Institute, Juni 2021. http://dx.doi.org/10.51414/sei2021.010.

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The need for a managed transition away from fossil fuel production raises the question of whether and how countries are addressing this need in their national communications to the UN Framework Convention on Climate Change (UNFCCC). A previous 2019 analysis of the first round of nationally determined contributions (NDCs) and long-term, low-emissions development strategies (LT-LEDS) found that few countries discussed how they would address fossil fuel production as part of their climate mitigation activities. Here, we examine new and updated NDCs and LT-LEDS, finding a growing number of NDCs and LT-LEDS that address fossil fuel production as part of mitigation. For the first time, several countries incorporate policies and/ or pathways for a managed decline of fossil fuel production. In contrast, many others foresee continued or expanded fossil fuel production, with no mention of efforts to prepare for a transition. Opportunities remain for countries to make better use of NDCs and LT-LEDS to align fossil fuel production with the Paris Agreement, including by more comprehensively reflecting on the equity implications of their plans, as well as addressing how countries plan to diversify their economies, ensure a just transition for workers, and cooperate internationally on a managed wind-down of fossil fuel supply. As COP26 approaches, this window of opportunity is still open, but it is rapidly closing.

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Agrawal, Govind P. Conference on Nonlinear Dynamics in Optical Systems (NDOS '95) Held in 5-7 Jun 1995. Fort Belvoir, VA: Defense Technical Information Center, Januar 1996. http://dx.doi.org/10.21236/ada303335.

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Althoff, J. L., M. L. Apicella, M. P. Bernier, S. Singh und D. B. Thompson. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 7. NDDL User's Guide. Fort Belvoir, VA: Defense Technical Information Center, November 1985. http://dx.doi.org/10.21236/ada181955.

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Montain, Scott J., Susan J. McGraw, Matther R. Ely, Frederick Dupont und William J. Tharion. On-The-Move Nutrient Delivery System (NDS): User Acceptability of Rotary Flow Control Version. Fort Belvoir, VA: Defense Technical Information Center, April 2009. http://dx.doi.org/10.21236/ada496714.

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Apicella, M. L., und S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 36. DDL to NDDL Translator Test Plan. Fort Belvoir, VA: Defense Technical Information Center, September 1990. http://dx.doi.org/10.21236/ada250469.

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Apicella, M. L., und S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 38. DDL to NDDL Translator Build Instructions. Fort Belvoir, VA: Defense Technical Information Center, September 1990. http://dx.doi.org/10.21236/ada250471.

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Aguilar Herrera, María Alejandra, und Alba Paula Granados Agüero. Inclusion of human, ethnic and gender rights in the Nationally Determined Contributions (NDCs) of Colombia and Peru (in Spanish). Rights and Resources Initiative, März 2021. http://dx.doi.org/10.53892/zltf9832.

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In December 2015, the Paris Agreement was adopted at the 21st Conference of the Parties (COP21) of the United Nations Framework Convention on Climate Change (UNFCCC). Five years after the submission the NDC proposals and their initial implementation, signatory countries had to update and share the progress of their NDCs in 2020. This study carried out by Asociación Ambiente y Sociedad, ONAMIAP (National Organization of Andean and Amazonian Indigenous Women of Peru) and RRI analyzes the degree that human rights, women’s rights, and the rights of Indigenous Peoples and Afro-descendants are included in the NDCs of Colombia and Peru, as well as in the processes related to updating them.

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Althoff, J. L., M. L. Apicella und S. Singh. Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 5. Neutral Data Definition Language (NDDL) Development Specification. Fort Belvoir, VA: Defense Technical Information Center, September 1990. http://dx.doi.org/10.21236/ada252450.

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