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Thematische Bibliographien / Nanocapsules – Toxicologie / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Nanocapsules – Toxicologie“

Autor: Grafiati

Veröffentlicht am 30. November 2024

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1

Chassot, Janaíne Micheli, Luana Mota Ferreira, Felipe Pereira Gomes, Letícia Cruz und Leandro Tasso. „Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions“. Brazilian Journal of Pharmaceutical Sciences 51, Nr. 4 (Dezember 2015): 803–10. http://dx.doi.org/10.1590/s1984-82502015000400006.

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abstract A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasone dipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column (250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL/min with UV detection at 254 nm. The calibration curve was found to be linear in the concentration range of 5.0-25.0 µg/mL with a correlation coefficient > 0.999. Precision was demonstrated by a relative standard deviation lower than 2.0%. Accuracy was assessed by the recovery test of BD from nanocapsules (98.03% to 100.35%). Specificity showed no interference from the components of nanocapsules or from the degradation products derived from acid, basic and photolytic conditions. In conclusion, the method is suitable to be applied to assay BD in bulk drug and in nanocapsules, and it can be employed to study stability and degradation kinetics.

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Zielińska, Aleksandra, Filipa Carreiró, Ana M. Oliveira, Andreia Neves, Bárbara Pires, D. Nagasamy Venkatesh, Alessandra Durazzo et al. „Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology“. Molecules 25, Nr. 16 (15.08.2020): 3731. http://dx.doi.org/10.3390/molecules25163731.

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Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.

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Charlie-Silva, Ives, Natália Martins Feitosa, Juliana Moreira Mendonça Gomes, Daniela Chemim de Melo Hoyos, Cristiano Campos Mattioli, Silas Fernandes Eto, Dayanne Carla Fernandes et al. „Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish“. PLOS ONE 15, Nr. 9 (24.09.2020): e0238823. http://dx.doi.org/10.1371/journal.pone.0238823.

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4

Bikash Medhi, Bikash Medhi, und Dr Swayamprava Dalai. „Polymeric Nanocapsules in Drug delivery“. International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, Nr. 4 (08.09.2022): 5933–35. http://dx.doi.org/10.37285/ijpsn.2022.15.4.1.

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The ever-increasing accomplishment of Nanotechnology in Science has raised the prospects of improving the properties and usability of an array of substances, minimizing the negative impact on human health as well as the environment. In the context of human health, continuous research is going on to obtain the maximum benefit of a pharmaceutical compound with a minimum dose by improving its delivery to the target site. Nanotechnology plays a key role in drug delivery providing target-oriented better therapeutic efficiency with minimal adverse effects. The widespread application potential of polymeric nanocapsules in drug delivery, diagnostics, biomedical imaging, and other related domains has made them one of the most extensively studied nanomaterials. Owing to their biocompatibility and biodegradability, much research has been dedicated to exploring the drug delivery aspect of polymeric nanocapsules. Several technological strategies have been developed in the last decade to improve the production protocol and choose appropriate materials to produce nanocapsules for superior performances. Polymeric nanocapsules are advantageous because of their excellent control over the release rate and modulation of the pharmacokinetic properties of various active ingredients.

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Bagale, Uday D., Shirish H. Sonawane, Bharat A. Bhanvase, Ravindra D. Kulkarni und Parag R. Gogate. „Green synthesis of nanocapsules for self-healing anticorrosion coating using ultrasound-assisted approach“. Green Processing and Synthesis 7, Nr. 2 (25.04.2018): 147–59. http://dx.doi.org/10.1515/gps-2016-0160.

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Abstract The present work deals with the production of nanocapsules containing a natural corrosion inhibition component. Azadirachta indica was encapsulated in urea-formaldehyde polymeric shell using ultrasound-assisted and conventional approaches of in situ polymerization. Subsequently nanocapsules were incorporated into clear epoxy polyamide to develop the green self-healing corrosion inhibition coating. The actual performance of the coating was evaluated based on the studies involving the repair of the crack of high solid surface coating. Corrosion inhibition of the healed area has been evaluated using the electrochemical impedance spectroscopy and immersion test based on the use of standard epoxy coating. The obtained results confirmed better corrosion protection in terms of the electrochemical impendence spectroscopy data and Tafel plot. It was found that current density decreases from 0.0011 A/cm2 (for standard epoxy coating) to 5.22 E−7 A/cm2 as 4 wt% nanocapsules incorporated in coating.

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Bulcão, R. P., F. A. de Freitas, E. Dallegrave, M. D. Arbo, P. Zielinsky, A. R. Pohlmann, S. S. Guterres und S. C. Garcia. „Acute toxicological evaluation of lipid-core nanocapsules“. Toxicology Letters 205 (August 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.971.

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Bulcão, R. P., F. A. de Freitas, C. D. G. Venturini, J. Durgante, G. Guerreiro, A. R. Pohlmann, S. S. Guterres und S. C. Garcia. „Subchronic toxicological evaluation of lipid-core nanocapsules“. Toxicology Letters 205 (August 2011): S287. http://dx.doi.org/10.1016/j.toxlet.2011.05.972.

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8

Mazzarino, Letícia, Ismael Casagrande Bellettini, Edson Minatti und Elenara Lemos-Senna. „Development and validation of a fluorimetric method to determine curcumin in lipid and polymeric nanocapsule suspensions“. Brazilian Journal of Pharmaceutical Sciences 46, Nr. 2 (Juni 2010): 219–26. http://dx.doi.org/10.1590/s1984-82502010000200008.

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A simple, rapid, and sensitive fluorimetric method was developed and validated to quantify curcumin in lipid and polymeric nanocapsule suspensions, using acetonitrile as a solvent. The excitation and emission wavelengths were set at 397 nm and 508 nm, respectively. The calibration graph was linear from 0.1 to 0.6 µg/mL with a correlation coefficient of 0.9982. The detection and quantitation limits were 0.03 and 0.10 µg/mL, respectively. The validation results confirmed that the developed method is specific, linear, accurate, and precise for its intended use. The current method was successfully applied to the evaluation of curcumin content in lipid and polymeric nanocapsule suspensions during the early stage of formulation development.

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Majda Benabbes, Aicha Fahri, Yassir El alaoui, Naoual Cherkaoui, Abdelkader Laatiris und Younes Rahali. „Formulation of parenteral nutrition based on argan oil nanocapsule system using d-optimal mixture design“. International Journal of Research in Pharmaceutical Sciences 11, Nr. 3 (21.07.2020): 3857–65. http://dx.doi.org/10.26452/ijrps.v11i3.2567.

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In parenteral nutrition, the lipid emulsions are usually presented separately from other components. The admixture is made just before or during administration because of limited stability. The purpose of the present study is the formulation of lipid nanocapsules (LNC) based on Argan-oil and their introduction into preparations for parenteral nutrition, then the evaluation of their stability. The lipid nanocapsules have been prepared according to the phase inversion temperature method. The experimental design was used to determine the feasibility of LNC with Argan oil (A.O.-LNC), the evaluation of their size and the stability in the final mixing parenteral nutrition. The average size of the LNC was chosen as a response. The LNC based on 14% Argan oil, 6% Labrafac ®, 55% water and 25% of Solutol ® with an average size of 44 nm was selected for the preparation of the parenteral nutrition. The particle size distribution with a value of 70 nm and a polydispersity index of 0.102 indicates the homogeneity of the populations of particles. The statistical analysis shows the excellent stability of parenteral nutrition for 14 days.

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Grandhi, Srikar, Moawia Al-Tabakha und Prameela Rani Avula. „Enhancement of Liver Targetability through Statistical Optimization and Surface Modification of Biodegradable Nanocapsules Loaded with Lamivudine“. Advances in Pharmacological and Pharmaceutical Sciences 2023 (18.11.2023): 1–16. http://dx.doi.org/10.1155/2023/8902963.

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The intention of the current work was to develop and optimize the formulation of biodegradable polymeric nanocapsules for lamivudine (LMV) in order to obtain desired physical characteristics so as to have improved liver targetability. Nanocapsules were prepared in this study as aqueous-core nanocapsules (ACNs) with poly(lactide-co-glycolide) using a modified multiple emulsion technique. LMV was taken as a model drug to investigate the potential of ACNs developed in this work in achieving the liver targetability. Three formulations factors were chosen and 33 factorial design was adopted. The selected formulation factors were optimized statistically so as to have the anticipated characteristics of the ACNs viz. maximum entrapment efficiency, minimum particle size, and less drug release rate constant. The optimized LMV-ACNs were found to have 71.54 ± 1.93% of entrapment efficiency and 288.36 ± 2.53 nm of particle size with zeta potential of −24.7 ± 1.2 mV and 0.095 ± 0.006 h−1 of release rate constant. This optimized formulation was subjected to surface modification by treating with sodium lauryl sulphate (SLS), which increased the zeta potential to a maximum of −41.6 ± 1.3 mV at a 6 mM concentration of SLS. The results of in vivo pharmacokinetics from blood and liver tissues indicated that hepatic bioavailability of LMV was increased from 13.78 ± 3.48 μg/mL ∗ h for LMV solution to 32.94 ± 5.12 μg/mL ∗ h for the optimized LMV-ACNs and to 54.91 ± 6.68 μg/mL ∗ h for the surface-modified LMV-ACNs.

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Lopes, Leonardo Q. S., Cayane G. Santos, Rodrigo de Almeida Vaucher, Renata P. Raffin, Aleksandro S. da Silva, Dilmar Baretta, Ana Paula Maccari et al. „Ecotoxicology of Glycerol Monolaurate nanocapsules“. Ecotoxicology and Environmental Safety 139 (Mai 2017): 73–77. http://dx.doi.org/10.1016/j.ecoenv.2017.01.019.

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de Castro Jorge Silva, Arthur, Mariana Härter Remirão, Caroline Gomes Lucas, William Borges Domingues, Tony Silveira, Julia Dame Paschoal, Denise S. Jornada et al. „Effects of chitosan-coated lipid-core nanocapsules on bovine sperm cells“. Toxicology in Vitro 40 (April 2017): 214–22. http://dx.doi.org/10.1016/j.tiv.2017.01.017.

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13

Marto, J., P. Pinto, M. Fitas, L. M. Gonçalves, A. J. Almeida und H. M. Ribeiro. „Safety assessment of starch-based personal care products: Nanocapsules and pickering emulsions“. Toxicology and Applied Pharmacology 342 (März 2018): 14–21. http://dx.doi.org/10.1016/j.taap.2018.01.018.

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Kumar, AshwiniG, Amit Bhat und Shoba Rani. „Preparation and characterization of diltiazem nanocapsules: Influence of various polymers“. Asian Journal of Pharmaceutics 4, Nr. 3 (2010): 224. http://dx.doi.org/10.4103/0973-8398.72123.

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15

Guterres, Sílvia S., Marta P. Alves und Adriana R. Pohlmann. „Polymeric Nanoparticles, Nanospheres and Nanocapsules, for Cutaneous Applications“. Drug Target Insights 2 (Januar 2007): 117739280700200. http://dx.doi.org/10.1177/117739280700200002.

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Fracasso, Rafael, Marília Baierle, Gabriela Goëthel, Anelise Barth, Fernando Freitas, Sabrina Nascimento, Louise Altknecht et al. „Evaluation of potential acute cardiotoxicity of biodegradable nanocapsules in rats by intravenous administration“. Toxicology Research 5, Nr. 1 (2016): 168–79. http://dx.doi.org/10.1039/c5tx00207a.

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17

Bulcão, Rachel P., Fernando A. Freitas, Cristina G. Venturini, Eliane Dallegrave, Juliano Durgante, Gabriela Göethel, Carlos Thadeu S. Cerski et al. „Acute and Subchronic Toxicity Evaluation of Poly(ɛ-Caprolactone) Lipid-Core Nanocapsules in Rats“. Toxicological Sciences 132, Nr. 1 (12.12.2012): 162–76. http://dx.doi.org/10.1093/toxsci/kfs334.

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18

Martins, Isabela, Kátia Cristina Cruz Capel und Denis Moledo de Souza Abessa. „Adults of Sun Coral Tubastraea coccinea (Lesson 1829) Are Resistant to New Antifouling Biocides“. Toxics 12, Nr. 1 (06.01.2024): 44. http://dx.doi.org/10.3390/toxics12010044.

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Biocides used in antifouling (AF) paints, such as 4,5-dichlorine-2-n-octyl-4-isothiazole-3-one (DCOIT), can gradually leach into the environment. Some AF compounds can persist in the marine environment and cause harmful effects to non-target organisms. Nanoengineered materials, such as mesoporous silica nanocapsules (SiNCs) containing AF compounds, have been developed to control their release rate and reduce their toxicity to aquatic organisms. This study aimed to evaluate the acute toxicity of new nanoengineered materials, SiNC-DCOIT and a silver-coated form (SiNC-DCOIT-Ag), as well as the free form of DCOIT and empty nanocapsules (SiNCs), on the sun coral Tubastraea coccinea. T. coccinea is an invasive species and can be an alternative test organism for evaluating the risks to native species, as most native corals are currently threatened. The colonies were collected from the Alcatrazes Archipelago, SP, Brazil, and acclimatized to laboratory conditions. They were exposed for 96 h to different concentrations of the tested substances: 3.33, 10, 33, and 100 µg L−1 of free DCOIT; 500, 1000, 2000, and 4000 µg L−1 of SiNC; and 74.1, 222.2, 666.7, and 2000 µg L−1 of SiNC-DCOIT and SiNC-DCOIT-Ag. The test chambers consisted of 500 mL flasks containing the test solutions, and the tests were maintained under constant aeration, a constant temperature of 23 ± 2 °C, and photoperiod of 12 h:12 h (light/dark). At the end of the experiments, no lethal effect was observed; however, some sublethal effects were noticeable, such as the exposure of the skeleton in most of the concentrations and replicates, except for the controls, and embrittlement at higher concentrations. Adults of T. coccinea were considered slightly sensitive to the tested substances. This resistance may indicate a greater capacity for proliferation in the species, which is favored in substrates containing antifouling paints, to the detriment of the native species.

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Yurgel, V., T. Collares und F. Seixas. „Developments in the use of nanocapsules in oncology“. Brazilian Journal of Medical and Biological Research 46, Nr. 6 (Juni 2013): 486–501. http://dx.doi.org/10.1590/1414-431x20132643.

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Chassot, Janaíne Micheli, Luana Mota Ferreira, Felipe Pereira Gomes, Cristiane de Bona da Silva, Leandro Tasso und Letícia Cruz. „Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery“. Brazilian Journal of Pharmaceutical Sciences 52, Nr. 4 (Dezember 2016): 735–40. http://dx.doi.org/10.1590/s1984-82502016000400018.

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Michalec, François-Gaël, Markus Holzner, Anissa Souissi, Stefka Stancheva, Alexandre Barras, Rabah Boukherroub und Sami Souissi. „Lipid nanocapsules for behavioural testing in aquatic toxicology: Time–response of Eurytemora affinis to environmental concentrations of PAHs and PCB“. Aquatic Toxicology 170 (Januar 2016): 310–22. http://dx.doi.org/10.1016/j.aquatox.2015.08.010.

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Alidee, Tahani, Hoda Habbal und Francois Karabet. „Chitosan- (Prunus avium) Gum Nanocapsules Loaded with Orange Peel Extract“. Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, Nr. 1 (20.06.2023): 194–201. http://dx.doi.org/10.31351/vol32iss1pp194-201.

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The orange peel extract (OE) is an additive material that has been used widely as a natural antioxidant source and bioactive compounds in Pharmaceutical and food sector. The poor stability and degradation of this extract were considered problems in the industry. New technologies have been introduced recently to prevent this degradation as encapsulation. In this work, chitosan (CS) and Prunus avium gum (PG) were proposed as promising based materials for encapsulation OE via ionic gelation method. The effect of different ratios of CS: PG and CS: OE on encapsulation efficiency (EE %) and the capsules size were investigated. The EE% of CS-PG was ranged from 60.63 to 87.06 % with a size range of 40 to 95nm according to Atomic Force Microscope (AFM) images. The formulation with the highest EE% was chosen to be characterized by FTIR, scanning electron microscope (SEM), and in vitro release study. The FTIR spectra confirm the cross-linking between the NH3+ group in CS and the negative functional group (-COO-) in PG. According to SEM micrographs, the capsules showed a spongy porous structure. The in vitro release study indicated that the release of OE from CS-PG matrix in the acidic and neutral medium was 55.15 and 52.67% respectively after incubation for 240 minutes. This study found that CS-PG can be used as an effective wall matrix for encapsulating OE and delivering it into the gastrointestinal system.

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Izaguirry, Aryele Pinto, Natasha Frasson Pavin, Melina Bucco Soares, Cristiano Chiapinotto Spiazzi, Flávio Arci Araújo, Luana Roberta Michels, Fábio Gallas Leivas, Daniela dos Santos Brum, Sandra Elisa Haas und Francielli Weber Santos. „Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats“. Toxicology Research 5, Nr. 6 (2016): 1561–72. http://dx.doi.org/10.1039/c6tx00203j.

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Brum, Aelson A. S., Médelin M. da Silva, Priscilla P. dos Santos, Allana V. S. Brasil, Karina Paese, Silvia S. Guterres, Simone H. Flôres und Alessandro de O. Rios. „The Influence of Heating and Photosensitization on the Stability of Lutein- Loaded Lipid-Core Nanocapsules“. Current Bioactive Compounds 16, Nr. 9 (24.11.2020): 1340–45. http://dx.doi.org/10.2174/1573407216666200211094654.

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Background: Despite lutein is unstable in light, heat, and oxygen, it is a good quencher of singlet oxygen. The present study evaluated the stability of lutein (92% of purity) in Lipid-core Nanocapsules (Lutein-LNC) prepared through interfacial deposition of preformed polymer, during photosensitization (5-25°C) and heating (70-90°C). Methods: The Lutein-LNC was characterized and presented a polydispersity index of 0.11, an average diameter of 191 nm (dynamic light scattering), zeta potential of -9.14 mV and entrapment efficiency of 100%. Results and Discussion: During photosensitization and heating, Lutein-LNC exhibited activation Energy (Ea) of 24.67 kcal/mol and 9.96 kcal/mol, respectively, and these values of Lutein-LNC were higher than free lutein values, reported in other studies for both experiments. Conclusion: The results obtained in this study suggested that nanotechnology can improve the stability of lutein for future applications in the food industry.

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Srikar, Grandhi, und Avula Prameela Rani. „Tenofovir Loaded Poly (Lactide-Co-Glycolide) Nanocapsules: Formulation Optimization by Desirability Functions Approach“. Indian Journal of Pharmaceutical Education and Research 54, Nr. 2s (29.05.2020): s230—s240. http://dx.doi.org/10.5530/ijper.54.2s.79.

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Bulcão, Rachel P., Guilherme B. Bubols, Sabrina N. Nascimento, Bruna Gauer, Elisa Sauer, Marília Baierle, Mariele F. Charão et al. „Do poly(epsilon-caprolactone) lipid-core nanocapsules induce oxidative or inflammatory damage after in vivo subchronic treatment?“ Toxicology Research 4, Nr. 4 (2015): 994–1005. http://dx.doi.org/10.1039/c5tx00030k.

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Jiang, Xuehong, Shuaishuai Wang und Hui Chen. „A Novel Fabrication of Dose-Dependent Injectable Curcumin Biocomposite Hydrogel System Anesthetic Delivery Method for Care and Management of Musculoskeletal Pain“. Dose-Response 18, Nr. 3 (01.07.2020): 155932582092955. http://dx.doi.org/10.1177/1559325820929555.

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Chronic musculoskeletal pain has biological, psychological, and social components. In this article, we have demonstrated the easily injectable nanocomposite carrier for the treatment of chronic musculoskeletal pain. Briefly, the curcumin (Cur) loaded with lipid nanocapsules (LNCs; Cur@LNCs) using the phase invasion method. The synthesized Cur@LNCs were characterized by using scanning electron microscopy, transmittance electron microscopy, and the size of the fabricated nanoparticles confirmed by dynamic light scattering analysis. The synthesized Cur@LNC injectable hydrogel shows excellent results in vivo in the rat model. We have examined the efficiency of the chronic constriction injury in the rat model and induced the pain using thermal paw withdrawal latency. The injectable hydrogels Cur@LNCs display a remarkable reduction in pain 7 days post administrations compared to the untreated group animals. This work could establish the preclinical candidate of the neuropathic pain response in the future.

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Giacomeli, Renata, Flavia Elizabete Guerra Teixeira, Felipe Barbosa Carvalho, Camila Oliveira Pacheco, Alcides José Martins Parisotto, Ana Claudia Funguetto Ribeiro, Marcelo Gomes de Gomes und Sandra Elisa Haas. „Curcumin-loaded poly(ϵ-caprolactone) lipid-core nanocapsules: Evaluation of fetal and maternal toxicity“. Food and Chemical Toxicology 144 (Oktober 2020): 111625. http://dx.doi.org/10.1016/j.fct.2020.111625.

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Diyanat, Marjan, Hamid Saeidian, Sara Baziar und Zohreh Mirjafary. „Preparation and characterization of polycaprolactone nanocapsules containing pretilachlor as a herbicide nanocarrier“. Environmental Science and Pollution Research 26, Nr. 21 (24.05.2019): 21579–88. http://dx.doi.org/10.1007/s11356-019-05257-0.

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Rampelotto, Camila Reck, Viviane Gonçalves Pereira, Larissa da Silva Silveira, Aline Rossato, Alencar Kolinski Machado, Michele Rorato Sagrillo, André Gündel, Marilise Escobar Burger, Scheila Rezende Schaffazick und Cristiane de Bona da Silva. „Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells“. Toxicology in Vitro 78 (Februar 2022): 105259. http://dx.doi.org/10.1016/j.tiv.2021.105259.

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Remião, Mariana Härter, Caroline Gomes Lucas, William Borges Domingues, Tony Silveira, Nathaniele Nebel Barther, Eliza Rossi Komninou, Andrea Cristina Basso et al. „Melatonin delivery by nanocapsules during in vitro bovine oocyte maturation decreased the reactive oxygen species of oocytes and embryos“. Reproductive Toxicology 63 (August 2016): 70–81. http://dx.doi.org/10.1016/j.reprotox.2016.05.016.

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Lucas, Caroline Gomes, Mariana Härter Remião, Eliza Rossi Komninou, William Borges Domingues, Cristina Haas, Priscila Marques Moura de Leon, Vinicius Farias Campos et al. „Tretinoin-loaded lipid-core nanocapsules decrease reactive oxygen species levels and improve bovine embryonic development during in vitro oocyte maturation“. Reproductive Toxicology 58 (Dezember 2015): 131–39. http://dx.doi.org/10.1016/j.reprotox.2015.10.004.

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Leite, Elaine Amaral, Andrea Grabe-Guimarães, Homero Nogueira Guimarães, George Luiz Lins Machado-Coelho, Gillian Barratt und Vanessa C. F. Mosqueira. „Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices“. Life Sciences 80, Nr. 14 (März 2007): 1327–34. http://dx.doi.org/10.1016/j.lfs.2006.12.019.

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Erdoğar, Nazlı, Safiye Akkın, Thorbjorn T. Nielsen, Esin Özçelebi, Batuhan Erdoğdu, Emirhan Nemutlu, Alper B. İskit und Erem Bilensoy. „Development of oral aprepitant-loaded chitosan–polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation“. Journal of Pharmaceutical Investigation 51, Nr. 3 (13.01.2021): 297–310. http://dx.doi.org/10.1007/s40005-020-00511-x.

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Stecanella, Luciano Aparecido, Stephânia Fleury Taveira, Ricardo Neves Marreto, Marize C. Valadares, Marcelo de Sousa Vieira, Massuo Jorge Kato und Eliana Martins Lima. „Development and characterization of PLGA nanocapsules of grandisin isolated from Virola surinamensis: in vitro release and cytotoxicity studies“. Revista Brasileira de Farmacognosia 23, Nr. 1 (Januar 2013): 153–59. http://dx.doi.org/10.1590/s0102-695x2012005000128.

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Zou, Rui, Junwei Li, Ting Yang, Yong Zhang, Ju Jiao, Ka-Leung Wong und Jing Wang. „Biodegradable manganese engineered nanocapsules for tumor-sensitive near-infrared persistent luminescence/magnetic resonance imaging and simultaneous chemotherapy“. Theranostics 11, Nr. 17 (2021): 8448–63. http://dx.doi.org/10.7150/thno.59840.

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Kia, Zahra Abrishami, Seyede Tayebeh Sadati Bizaki, Elham Asaádi Ghareh Tapeh, Shadmehr Mirdar Harijani, Nayyereh Katal und Roya Gorji Baziary. „Recovering the angiogenic/angiostatic balance in NNK-induced lung carcinoma via 12 weeks of submaximal swimming and Nigella sativa nanocapsule“. Toxicology Reports 9 (2022): 1452–60. http://dx.doi.org/10.1016/j.toxrep.2022.06.018.

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Ma, Li, Meng Yu, Yingjian Ma, Linying Gao, Shouhe Pan, Xuefeng Li, Xuemin Wu, Yong Xu, Sen Pang und Ping Wang. „Ascendancy of pyraclostrobin nanocapsule formulation against Rhizoctonia solani: From a perspective of fungus“. Pesticide Biochemistry and Physiology 197 (Dezember 2023): 105682. http://dx.doi.org/10.1016/j.pestbp.2023.105682.

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Pramudya Wardana, Andika, Nanik Siti Aminah, Alfinda Novi Kristanti, Y. Sri Wulan Manuhara, Mochamad Zakki Fahm, Teguh Hari Sucipto, Muhammad Ikhlas Abdjan und Indriani. „Gynura procumbens NANOENCAPSULATION: A NOVEL PROMISING APPROACH TO COMBAT DENGUE INFECTION“. RASAYAN Journal of Chemistry 16, Nr. 02 (2023): 0976–083. http://dx.doi.org/10.31788/rjc.2023.1628298.

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Nanoencapsulation of G. procumbens with polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) is intended to increase anti-dengue activity and prevent its bioactive deterioration. The particle size of Ga-NPs was 161.00 ± 2.17 nm with a PDI value of 0.33 ± 0.02 while the particle size of Gp-NPs was 136.33 ± 0.47 nm with a PDI value of 0.34 ± 0.01. Those indicated both Ga-NPs and Gp-NPs had a homogeneous particle size distribution. Moreover, both nanocapsules showed stability at 30-100oC but were less stable at high pH and salt concentrations. Ga-NPs have a %LE (96.236 ± 1.156%) higher than the %LE of Gp-NPs (95.567 ± 0.334 %), but release of Gp-NPs is better than Ga-NPs. G. procumbens extract, Ga-NPs, and Gp-NPs exhibited anti-dengue activity with IC50 values of 11.22, 7.67, and 12.75 µg/mL, respectively. However, Ga-NPs and Gp-NPs are more potent because they have higher SI values with low cytotoxicity (CC50) compared to G. procumbens extract. Herein, nanoencapsulation of G. procumbens is proved to increase bioavailability and controlled release and allow precision targeting of bioactive compounds to enhance bioactivity activity.

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Madan, Jyotsana R., Izharahemad N. Ansari, Kamal Dua und Rajendra Awasthi. „Formulation and In Vitro Evaluation of Casein Nanoparticles as Carrier for Celecoxib“. Advanced Pharmaceutical Bulletin 10, Nr. 3 (11.05.2020): 408–17. http://dx.doi.org/10.34172/apb.2020.049.

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Purpose : The objective of this work was to formulate casein (CAS) nanocarriers for the dissolution enhancement of poorly water soluble drug celecoxib (CLXB). Methods: The CLXB loaded CAS nanocarriers viz., nanoparticles, reassembled CAS micelles and nanocapsules were prepared using sodium caseinate (SOD-CAS) as a carrier to enhance the solubility of CLXB. The prepared formulations were characterized for particle size, polydispersity index, zeta potential, percentage entrapment efficiency, and surface morphology for the selection of best formulation. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray powder diffraction study was used to for the confirmation of encapsulation of CLXB. Further, in vitro drug dissolution, ex-vivo permeation studies on chicken ileum and stability studies were carried out. Results: The CLXB loaded casein nanoparticles (CNP) (batch A2) showed a particle size diameter 216.1 nm, polydispersity index 0.422 with percentage entrapment efficiency of 90.71% and zeta potential of -24.6 mV. Scanning electron microscopy of suspension confirmed globular shape of CNP. The in vitro release data of optimized batch followed non Fickian diffusion mechanism. The ex vivo permeation studies on chicken ileum of CLXB loaded CNP showed permeation through mucous membrane as compared to pure CLXB. The apparent permeability of best selected freeze dried CLXB loaded CNP (batch A2) was higher and gradually increased from 0.90 mg/cm2 after 10 min to a maximum of 1.95 mg/cm2 over the subsequent 90 min. A higher permeation was recorded at each time point than that of the pure CLXB. Conclusion: The study explored the potential of CAS as a carrier for solubility enhancement of poorly water soluble drugs.

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Portilla, Silvia, Lucía Fernández, Diana Gutiérrez, Ana Rodríguez und Pilar García. „Encapsulation of the Antistaphylococcal Endolysin LysRODI in pH-Sensitive Liposomes“. Antibiotics 9, Nr. 5 (09.05.2020): 242. http://dx.doi.org/10.3390/antibiotics9050242.

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Phage lysins are promising new therapeutics against multidrug-resistant bacteria. These so-called enzybiotics offer, amongst their most notable advantages, high target specificity and low resistance development. Moreover, there are numerous recent and ongoing studies aimed at demonstrating the efficacy and safety of endolysins in animal models or even in clinical trials. Nonetheless, as is the case for other antimicrobials, it is important to assess potential strategies that may broaden their potential applications or improve their stability. Encapsulation, for instance, has given very good results for some antibiotics. This study sought to evaluate the feasibility of encapsulating an endolysin against the opportunistic human pathogen Staphylococcus aureus, one of the most problematic bacteria in the context of the current antibiotic resistance crisis. Endolysin LysRODI has antimicrobial activity against many S. aureus strains from different sources, including methicillin-resistant S. aureus (MRSA) isolates. Here, this protein was encapsulated in pH-sensitive liposomes with an efficacy of approximately 47%, retaining its activity after being released from the nanocapsules. Additionally, the encapsulated endolysin effectively reduced S. aureus cell counts by > 2log units in both planktonic cultures and biofilms upon incubation at pH 5. These results demonstrate the viability of LysRODI encapsulation in liposomes for its targeted delivery under mild acidic conditions.

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Zhou, Ying, Yuxin Guo, Lufei Chen, Xiaoli Zhang, Wei Wu, Zhimin Yang, Xuejie Li, Yuanzhuo Wang, Zhiyuan Hu und Zihua Wang. „Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy“. Theranostics 12, Nr. 12 (2022): 5488–503. http://dx.doi.org/10.7150/thno.73104.

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El-Gogary, Riham I., Maha Nasr, Laila A. Rahsed und Mohamed A. Hamzawy. „Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer: Preparation and in vitro/in vivo appraisal“. Life Sciences 298 (Juni 2022): 120500. http://dx.doi.org/10.1016/j.lfs.2022.120500.

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Itishom, Reny, Ifan Ali Wafa, David Setyo Budi und Nando Reza Pratama. „Oral Delivery of Purple Sweet Potato (Ipomoea batatas L.) Extract-Loaded Carboxymethyl Chitosan and Alginate Nanocapsule in Streptozotocininduced Diabetic Mice“. Indian Journal of Pharmaceutical Education and Research 55, Nr. 3 (16.08.2021): 709–14. http://dx.doi.org/10.5530/ijper.55.3.143.

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Ghaderpoori, Mansour, Ali Jafari, Efat Nazari, Marzieh Rashidipour, Afshin Nazari, Farzaneh Chehelcheraghi, Bahram Kamarehie und Reza Rezaee. „Preparation and characterization of loaded paraquat- polymeric chitosan/xantan/tripolyphosphate nanocapsules and evaluation for controlled release“. Journal of Environmental Health Science and Engineering 18, Nr. 2 (28.09.2020): 1057–66. http://dx.doi.org/10.1007/s40201-020-00527-3.

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Imperlini, Esther, Federica Massaro und Francesco Buonocore. „Antimicrobial Peptides against Bacterial Pathogens: Innovative Delivery Nanosystems for Pharmaceutical Applications“. Antibiotics 12, Nr. 1 (16.01.2023): 184. http://dx.doi.org/10.3390/antibiotics12010184.

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The introduction of antibiotics has revolutionized the treatment and prevention of microbial infections. However, the global spread of pathogens resistant to available antibiotics is a major concern. Recently, the WHO has updated the priority list of multidrug-resistant (MDR) species for which the discovery of new therapeutics is urgently needed. In this scenario, antimicrobial peptides (AMPs) are a new potential alternative to conventional antibiotics, as they show a low risk of developing antimicrobial resistance, thus preventing MDR bacterial infections. However, there are limitations and challenges related to the clinical impact of AMPs, as well as great scientific efforts to find solutions aimed at improving their biological activity, in vivo stability, and bioavailability by reducing the eventual toxicity. To overcome some of these issues, different types of nanoparticles (NPs) have been developed for AMP delivery over the last decades. In this review, we provide an update on recent nanosystems applied to AMPs, with special attention on their potential pharmaceutical applications for the treatment of bacterial infections. Among lipid nanomaterials, solid lipid NPs and lipid nanocapsules have been employed to enhance AMP solubility and protect peptides from proteolytic degradation. In addition, polymeric NPs, particularly nanogels, are able to help in reducing AMP toxicity and also increasing AMP loading. To boost AMP activity instead, mesoporous silica or gold NPs can be selected due to their easy surface functionalization. They have been also used as nanocarriers for different AMP combinations, thus synergistically potentiating their action against pathogens.

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Mroginski Weber, Douglas, Guilherme Teixeira Voss, Renata Leivas de Oliveira, Caren A. R. da Fonseca, Jaini Paltian, K. C. Rodrigues, Francine Rodrigues Ianiski, R. A. Vaucher, Cristiane Luchese und Ethel Antunes Wilhelm. „Topic application of meloxicam-loaded polymeric nanocapsules as a technological alternative for treatment of the atopic dermatitis in mice“. Journal of Applied Biomedicine 16, Nr. 4 (01.11.2018): 337–43. http://dx.doi.org/10.1016/j.jab.2018.03.003.

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Rodrigues Ianiski, Francine, Fernanda D'Avila da Silva, Ethel Antunes Wilhelm, Renata Streck Fernandes, Marta Palma Alves, Marta Maria Mederios Frescura Duarte und Cristiane Luchese. „Enhanced anti-inflammatory benefits of meloxicam-loaded lipid-core nanocapsules in a mouse pleurisy model: A comparative study with a free form drug“. Journal of Applied Biomedicine 14, Nr. 2 (01.04.2016): 105–12. http://dx.doi.org/10.1016/j.jab.2015.04.006.

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Huang, Xueping, Aiping Wang, Jian Luo, Yue Gao, Lei Guan, Peng Zhang, Feng Liu, Wei Mu und Beixing Li. „Lambda-cyhalothrin-loaded nanocapsules pose an unacceptable acute toxicological risk to zebrafish (Danio rerio) at the adult and larval stages but present an acceptable risk to embryos“. Journal of Hazardous Materials 422 (Januar 2022): 126853. http://dx.doi.org/10.1016/j.jhazmat.2021.126853.

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Guessous, Fadila, Jean-Claude Daran, Bernard Viossat, Georges Morgant, Xavier Labouze, Anne Laure Leroy, Monique Roch-Arveiller und Nguyen-Huy Dung. „Ternary Copper(II) Complexes With Indomethacin, a Potent Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis (Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II). Antiinflammatory Properties and Prevention of Gastrointestinal Side Effects by Nanocapsules“. Metal-Based Drugs 5, Nr. 6 (01.01.1998): 337–45. http://dx.doi.org/10.1155/mbd.1998.337.

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Two ternary copper(ll) complexes of indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2- methyl-1-H-indole-3-acetic acid] called hereafter lndo, were prepared and characterized by single crystal X-ray diffraction. The first complex Cu2(Indo)4(DMF)2 I crystallizes in space group P-1 (a = 10.829(2), b = 13.379(2), c = 16.491(3) Å; α = 105.58(2), β = 101.06(2), γ = 106.96(2)°; V= 2104.6(6) Å3, Z= 1). The title molecule is a centrosymmetric binuclear complex, with Cu atoms bridged by the carboxylate moieties of four indomethacinate ligands. The four nearest O atoms around each Cu atom form a square planar arrangement with the square pyramidal coordination completed by the O atom of N,N′-dimethylformamide. Daily administration for seven days of 1 mg/kg of indomethacin, I and I encapsulated into liposomes induces a weak inflammation of rat gastrointestinal tract. I was less inflammatory than indomethacin but the better protection was brought by encapsulation of the compound. This might be of interest in sustained therapies of chronic inflammatory diseases.

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