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1
Ndiaye, Seyni, Minhui Zhang, Mouhamed Fall, Nicolas M. Ayessou, Qi Zhang und Peiwu Li. „Current Review of Mycotoxin Biodegradation and Bioadsorption: Microorganisms, Mechanisms, and Main Important Applications“. Toxins 14, Nr. 11 (25.10.2022): 729. http://dx.doi.org/10.3390/toxins14110729.
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Mycotoxins are secondary metabolites produced by fungi. Food/feed contamination by mycotoxins is a great threat to food safety. The contamination can occur along the food chain and can cause many diseases in humans and animals, and it also can cause economic losses. Many detoxification methods, including physical, chemical, and biological techniques, have been established to eliminate mycotoxins in food/feed. The biological method, with mycotoxin detoxification by microorganisms, is reliable, efficient, less costly, and easy to use compared with physical and chemical ones. However, it is important to discover the metabolite’s toxicity resulting from mycotoxin biodegradation. These compounds can be less or more toxic than the parent. On the other hand, mechanisms involved in a mycotoxin’s biological control remain still unclear. Mostly, there is little information about the method used by microorganisms to control mycotoxins. Therefore, this article presents an overview of the most toxic mycotoxins and the different microorganisms that have a mycotoxin detoxification ability. At the same time, different screening methods for degradation compound elucidation are given. In addition, the review summarizes mechanisms of mycotoxin biodegradation and gives some applications.
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Schiefer, H. B. „Mycotoxicoses of domestic animals and their diagnosis“. Canadian Journal of Physiology and Pharmacology 68, Nr. 7 (01.07.1990): 987–90. http://dx.doi.org/10.1139/y90-150.
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Mycotoxins have been named "agents in search of a disease," and the considerable progress in analytical methodology over the last 10 years has not changed this very much. The following are factors that contribute to the difficulty of making a diagnosis: (1) nonspecificity of lesions; (2) masking of mycotoxic effects by secondary effects, e.g., through immunosuppression; (3) late appearance of a lesion, e.g., bone marrow damage or neoplasia; (4) interaction of several mycotoxins or presence of other toxicants or deficiency states; (5) species variation in the response to the mycotoxin(s); (6) difficulty of linking a late appearing effect with a demonstrable cause; (7) low doses of mycotoxins may cause stimulating effects; and (8) not being aware of the potential of a mycotoxin as a causative factor in disease. The mycotoxins of major importance in Canada are trichothecenes, ochratoxin, zearalenone, and ergot. It is concluded that the significance of mycotoxins for animals in Canada is likely generally underestimated.Key words: mycotoxins, domestic animals, diagnosis of mycotoxicoses.
3
Zhang, Kai, und Melissa Phillips. „Opinion: Multi-Mycotoxin Reference Materials“. Foods 11, Nr. 17 (23.08.2022): 2544. http://dx.doi.org/10.3390/foods11172544.
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The analysis of mycotoxins in food and feed using liquid chromatography coupled with mass spectrometry is considered advantageous because the hyphenated technology enables simultaneous determination of multiple mycotoxins. Multi-mycotoxin analysis requires special consideration of quality control parameters to ensure proper evaluation of data quality for all target mycotoxins in method development and routine sample analysis. Mycotoxin matrix reference materials, especially certified reference materials, are stable and homogeneous matrices with certified traceability, concentrations, and uncertainty for mycotoxin(s) of interest. The use of these reference materials for single mycotoxin analysis has been a well-accepted practice and should be extended to multi-mycotoxin analysis. This opinion piece discusses the following essential metrological and operational components to improve data quality: (1) purposes of multi-mycotoxin reference materials; (2) comparison of reference materials, certified reference materials, and in-house quality control materials; (3) advantages of using reference materials for multi-mycotoxin analysis; (4) current trends and challenges of multi-mycotoxin reference materials. Potential applications of reference materials discussed here can improve routine mycotoxin determination and will lead to better accuracy and consistency of results. Quality control processes that incorporate reference materials in the field of mycotoxin analysis ensure successful development and implementation of liquid chromatography mass spectrometry-based multi-mycotoxin methods.
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Wang, Wenjie, Xinle Liang, Yudong Li, Pinmei Wang und Nancy P. Keller. „Genetic Regulation of Mycotoxin Biosynthesis“. Journal of Fungi 9, Nr. 1 (22.12.2022): 21. http://dx.doi.org/10.3390/jof9010021.
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Mycotoxin contamination in food poses health hazards to humans. Current methods of controlling mycotoxins still have limitations and more effective approaches are needed. During the past decades of years, variable environmental factors have been tested for their influence on mycotoxin production leading to elucidation of a complex regulatory network involved in mycotoxin biosynthesis. These regulators are putative targets for screening molecules that could inhibit mycotoxin synthesis. Here, we summarize the regulatory mechanisms of hierarchical regulators, including pathway-specific regulators, global regulators and epigenetic regulators, on the production of the most critical mycotoxins (aflatoxins, patulin, citrinin, trichothecenes and fumonisins). Future studies on regulation of mycotoxins will provide valuable knowledge for exploring novel methods to inhibit mycotoxin biosynthesis in a more efficient way.
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SINPHITHAKKUL, PIYALUK, AMNART POAPOLATHEP, NARUMOL KLANGKAEW, KANJANA IMSILP, ANTONIO F. LOGRIECO, ZHAOWEI ZHANG und SARANYA POAPOLATHEP. „Occurrence of Multiple Mycotoxins in Various Types of Rice and Barley Samples in Thailand“. Journal of Food Protection 82, Nr. 6 (22.05.2019): 1007–15. http://dx.doi.org/10.4315/0362-028x.jfp-18-456.
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ABSTRACT The prevalence of mycotoxins is often increased by climatic conditions prevailing in tropical regions. Therefore, consumers in tropical countries such as Thailand have a higher risk of mycotoxin exposure. Existing reports have revealed mycotoxin contamination in rice. This study was conducted to determine the occurrence of multiple mycotoxins in barley and nine types of rice sold in Thailand and to assess consumer health risk. A total of 300 samples collected from various markets in Thailand were analyzed for the presence of 16 mycotoxins using a QuEChERS (quick, easy, cheap, effective, rugged, and safe) procedure and a triple quadrupole mass spectrometer equipped with an electrospray ionization source. Of the 300 samples, 124 (41.33%) were contaminated with at least one mycotoxin, and 38.71% of the mycotoxin-positive samples were simultaneously contaminated with more than one toxin. The incidence of mycotoxin contamination differed among the rice and barley samples. Beauvericin, diacetoxyscirpenol, zearalenone, and aflatoxins were the most frequently found mycotoxins. However, the concentrations of regulated mycotoxins were below the regulatory limits. The assessed mycotoxin exposure does not represent a health risk for Thai consumers because the estimated exposure concentrations were lower than the tolerable daily intake values established by the Joint FAO/WHO Expert Committee on Food Additives. However, our findings suggest that continued monitoring of mycotoxin contamination in rice and barley and concomitant risk assessments are warranted. HIGHLIGHTS
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Kazemi, Davar, Arash Chaychi Nosrati, Leila Modiri und Ali Shahriyari. „A Comparative Investigation on Egg Yolk Total Antioxidant Capacity Influencing Relativities to Mycotoxins - Ochratoxins“. Journal of Evolution of Medical and Dental Sciences 10, Nr. 10 (08.03.2021): 700–704. http://dx.doi.org/10.14260/jemds/2021/150.
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BACKGROUND Ochratoxins include a family of toxic secondary metabolites produced by several species of fungi of the genus aspergillus and penicillium. Mycotoxins1 are important environmental pollutants that can be generated in a variety of food and feed components. Nowadays, most mycotoxins can be identified at an acceptable level in terms of legal, veterinary and medical needs. We wanted to compare the egg yolk total antioxidant capacity relativities to mycotoxins ochratoxins (OTA) to determine surges in side effects of human consumption. METHODS Samples were tested by the indirect competitive enzyme-linked immunosorbent assay (ELISA) test kits according to the kit’s instructions. Finally, the collected data was analysed using SPSS software and descriptive statistics (contamination ratio, mean and standard deviation) and one-way analysis of variance. RESULTS Ochratoxin in all egg yolk samples of the studied 34 brands showed a minimum of 23.17 ppb and a maximum of 252.80 ppb. OTA residues indicate high risk levels to consumers. CONCLUSIONS According to the results, the transfer of mycotoxin metabolites to eggs has been in greater possibilities; therefore, control of mycotoxin contamination in laying hen diets and surveys in food and feed in intense risks is recommended to avoid the presence of mycotoxins in eggs intended for human consumption. KEY WORDS Mycotoxin, Total Antioxidant Capacity (TAC), OTA, Egg Yolk
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Al-Jaal, Belqes, Aishah Latiff, Sofia Salama, Huda Mohamed Hussain, Noora Abdulaziz Al-Thani, Noor Al-Naimi, Noof Al-Qasmi, Peter Horvatovich und Morana Jaganjac. „Analysis of Multiple Mycotoxins in the Qatari Population and Their Relation to Markers of Oxidative Stress“. Toxins 13, Nr. 4 (08.04.2021): 267. http://dx.doi.org/10.3390/toxins13040267.
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Mycotoxins are naturally occurring food toxins worldwide that can cause serious health effects. The measurement of mycotoxin biomarkers in biological fluids is needed to assess individuals’ exposure. The aim of this study was to investigate the incidence of mycotoxins in the Qatari population. Serum samples from 412 adults and urinary samples from 559 adults were analyzed for the presence of mycotoxin biomarkers. Multimycotoxin approaches have been applied, using liquid chromatography mass spectrometry methods. Samples were further analyzed for the oxidative stress markers and compared with regard to the incidence of mycotoxins. The presence of mycotoxins was identified in 37% of serum samples and in less than 20% of urine samples. It was found that 88% of positive of the samples were positive for only one mycotoxin, while 12% of positive samples had two or more mycotoxins. Trichothecenes and zearalenone metabolites were most commonly detected mycotoxins, followed by aflatoxins, roquefortine C and mycophenolic acid. The presence of mycotoxins was found to positively correlate with oxidative stress markers. The obtained results illustrate the importance of mycotoxin biomonitoring studies in humans and the need to elucidate the underlying mechanisms of mycotoxin-induced toxicity.
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Fumagalli, Francesca, Matteo Ottoboni, Luciano Pinotti und Federica Cheli. „Integrated Mycotoxin Management System in the Feed Supply Chain: Innovative Approaches“. Toxins 13, Nr. 8 (16.08.2021): 572. http://dx.doi.org/10.3390/toxins13080572.
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Exposure to mycotoxins is a worldwide concern as their occurrence is unavoidable and varies among geographical regions. Mycotoxins can affect the performance and quality of livestock production and act as carriers putting human health at risk. Feed can be contaminated by various fungal species, and mycotoxins co-occurrence, and modified and emerging mycotoxins are at the centre of modern mycotoxin research. Preventing mould and mycotoxin contamination is almost impossible; it is necessary for producers to implement a comprehensive mycotoxin management program to moderate these risks along the animal feed supply chain in an HACCP perspective. The objective of this paper is to suggest an innovative integrated system for handling mycotoxins in the feed chain, with an emphasis on novel strategies for mycotoxin control. Specific and selected technologies, such as nanotechnologies, and management protocols are reported as promising and sustainable options for implementing mycotoxins control, prevention, and management. Further research should be concentrated on methods to determine multi-contaminated samples, and emerging and modified mycotoxins.
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Widiyanti, Prima Mei, und Romsyah Maryam. „The Use of Mycotoxin Binder to Control Its Contamination in Feed“. Indonesian Bulletin of Animal and Veterinary Sciences 26, Nr. 2 (02.02.2017): 091. http://dx.doi.org/10.14334/wartazoa.v26i2.1329.
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<p class="awabstrak2">The climate in Indonesia as a tropical country is very condusive for the growth of mycotoxins producing fungi. Mycotoxins have properties as carcinogenic, mutagenic, teratogenic, estrogenic, neurotoxic, and immunotoxic. Mycotoxins reduce performance, appetite, weight, and immunity. They also cause reproductive disorders and generate the residues in animal products that affect human health. These can be prevented by controlling mycotoxins contamination in agricultural products that used for feed ingredients through good management practices (during planting, harvesting, and storage). Mycotoxins contamination can also be minimized by physical, chemical and biological treatments as well as the application of mycotoxin binders. This review describes the use of mycotoxin binders in animal feed. They are used as feed additives, may be derived from organic, inorganic materials or their combination. Combination of organic and inorganic substances proven to be more effective and efficient in controlling mycotoxin contamination. Therefore, it is recommended to use mycotoxin binders to prevent animal health disorder and to decrease mycotoxin residues in animal products.</p><p class="awabstrak3"> </p>
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Hoffmans, Yvette, Sara Schaarschmidt, Carsten Fauhl-Hassek und H. J. van der Fels-Klerx. „Factors during Production of Cereal-Derived Feed That Influence Mycotoxin Contents“. Toxins 14, Nr. 5 (25.04.2022): 301. http://dx.doi.org/10.3390/toxins14050301.
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Mycotoxins are naturally present in cereal-based feed materials; however, due to adverse effects on animal health, their presence in derived animal feed should be minimized. A systematic literature search was conducted to obtain an overview of all factors from harvest onwards influencing the presence and concentration of mycotoxins in cereal-based feeds. The feed production processes covered included the harvest time, post-harvest practices (drying, cleaning, storage), and processing (milling, mixing with mycotoxin binders, extrusion cooking, ensiling). Delayed harvest supports the production of multiple mycotoxins. The way feed materials are dried after harvest influences the concentration of mycotoxins therein. Applying fungicides on the feed materials after harvest as well as cleaning and sorting can lower the concentration of mycotoxins. During milling, mycotoxins might be redistributed in cereal feed materials and fractions thereof. It is important to know which parts of the cereals are used for feed production and whether or not mycotoxins predominantly accumulate in these fractions. For feed production, mostly the milling fractions with outer parts of cereals, such as bran and shorts, are used, in which mycotoxins concentrate during processing. Wet-milling of grains can lower the mycotoxin content in these parts of the grain. However, this is typically accompanied by translocation of mycotoxins to the liquid fractions, which might be added to by-products used as feed. Mycotoxin binders can be added during mixing of feed materials. Although binders do not remove mycotoxins from the feed, the mycotoxins become less bioavailable to the animal and, in the case of food-producing animals, to the consumer, lowering the adverse effects of mycotoxins. The effect of extruding cereal feed materials is dependent on several factors, but in principle, mycotoxin contents are decreased after extrusion cooking. The results on ensiling are not uniform; however, most of the data show that mycotoxin production is supported during ensiling when oxygen can enter this process. Overall, the results of the literature review suggest that factors preventing mycotoxin production have greater impact than factors lowering the mycotoxin contents already present in feed materials.
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Hoffmans, Yvette, Sara Schaarschmidt, Carsten Fauhl-Hassek und H. J. van der Fels-Klerx. „Factors during Production of Cereal-Derived Feed That Influence Mycotoxin Contents“. Toxins 14, Nr. 5 (25.04.2022): 301. http://dx.doi.org/10.3390/toxins14050301.
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Mycotoxins are naturally present in cereal-based feed materials; however, due to adverse effects on animal health, their presence in derived animal feed should be minimized. A systematic literature search was conducted to obtain an overview of all factors from harvest onwards influencing the presence and concentration of mycotoxins in cereal-based feeds. The feed production processes covered included the harvest time, post-harvest practices (drying, cleaning, storage), and processing (milling, mixing with mycotoxin binders, extrusion cooking, ensiling). Delayed harvest supports the production of multiple mycotoxins. The way feed materials are dried after harvest influences the concentration of mycotoxins therein. Applying fungicides on the feed materials after harvest as well as cleaning and sorting can lower the concentration of mycotoxins. During milling, mycotoxins might be redistributed in cereal feed materials and fractions thereof. It is important to know which parts of the cereals are used for feed production and whether or not mycotoxins predominantly accumulate in these fractions. For feed production, mostly the milling fractions with outer parts of cereals, such as bran and shorts, are used, in which mycotoxins concentrate during processing. Wet-milling of grains can lower the mycotoxin content in these parts of the grain. However, this is typically accompanied by translocation of mycotoxins to the liquid fractions, which might be added to by-products used as feed. Mycotoxin binders can be added during mixing of feed materials. Although binders do not remove mycotoxins from the feed, the mycotoxins become less bioavailable to the animal and, in the case of food-producing animals, to the consumer, lowering the adverse effects of mycotoxins. The effect of extruding cereal feed materials is dependent on several factors, but in principle, mycotoxin contents are decreased after extrusion cooking. The results on ensiling are not uniform; however, most of the data show that mycotoxin production is supported during ensiling when oxygen can enter this process. Overall, the results of the literature review suggest that factors preventing mycotoxin production have greater impact than factors lowering the mycotoxin contents already present in feed materials.
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Manni, Katariina, Sari Rämö, Marcia Franco, Marketta Rinne und Arto Huuskonen. „Occurrence of Mycotoxins in Grass and Whole-Crop Cereal Silages—A Farm Survey“. Agriculture 12, Nr. 3 (12.03.2022): 398. http://dx.doi.org/10.3390/agriculture12030398.
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Mycotoxin incidence in forage may heavily affect the amount of toxins consumed by cattle. However, many studies have focused on mycotoxin occurrence in cereals and there are less studies of forages, particularly of grass silages. For determining the occurrence of mycotoxins in farm silages under Northern European conditions in Finland, 37 grass silage and 6 whole-crop cereal silage batches were analysed separately for surface, core and, if present, visibly mouldy spots. Mycotoxins were found in 92% of the samples. All mouldy samples contained mycotoxins. Beauvericin was the most common mycotoxin in grass silages and roquefortine C in whole-crop cereal silages. In mouldy samples, beauvericin, mycophenolic acid and roquefortine C were the most common mycotoxins in the grass silage and mycophenolic acid in the whole-crop cereal silage. Aflatoxins were not found in any of the samples. On average, all samples contained more than one type of mycotoxin. Concentrations of mycotoxins varied considerably from very low to very high values. The results of this survey indicate that silage-fed ruminants can be exposed to a broad range of mycotoxins. The absence of visible moulds does not always indicate mycotoxin-free feed. All moulded samples contained mycotoxins and some at very high concentrations, and they contained more different types of mycotoxins than samples without visible mould. Thus, feeding mouldy feeds to animals should be avoided.
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Daud, Noshin, Valerie Currie, Gary Duncan, Freda Farquharson, Tomoya Yoshinari, Petra Louis und Silvia W. Gratz. „Prevalent Human Gut Bacteria Hydrolyse and Metabolise Important Food-Derived Mycotoxins and Masked Mycotoxins“. Toxins 12, Nr. 10 (13.10.2020): 654. http://dx.doi.org/10.3390/toxins12100654.
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Mycotoxins are important food contaminants that commonly co-occur with modified mycotoxins such as mycotoxin-glucosides in contaminated cereal grains. These masked mycotoxins are less toxic, but their breakdown and release of unconjugated mycotoxins has been shown by mixed gut microbiota of humans and animals. The role of different bacteria in hydrolysing mycotoxin-glucosides is unknown, and this study therefore investigated fourteen strains of human gut bacteria for their ability to break down masked mycotoxins. Individual bacterial strains were incubated anaerobically with masked mycotoxins (deoxynivalenol-3-β-glucoside, DON-Glc; nivalenol-3-β-glucoside, NIV-Glc; HT-2-β-glucoside, HT-2-Glc; diacetoxyscirpenol-α-glucoside, DAS-Glc), or unconjugated mycotoxins (DON, NIV, HT-2, T-2, and DAS) for up to 48 h. Bacterial growth, hydrolysis of mycotoxin-glucosides and further metabolism of mycotoxins were assessed. We found no impact of any mycotoxin on bacterial growth. We have demonstrated that Butyrivibrio fibrisolvens, Roseburia intestinalis and Eubacterium rectale hydrolyse DON-Glc, HT-2 Glc, and NIV-Glc efficiently and have confirmed this activity in Bifidobacterium adolescentis and Lactiplantibacillus plantarum (DON-Glc only). Prevotella copri and B. fibrisolvens efficiently de-acetylated T-2 and DAS, but none of the bacteria were capable of de-epoxydation or hydrolysis of α-glucosides. In summary we have identified key bacteria involved in hydrolysing mycotoxin-glucosides and de-acetylating type A trichothecenes in the human gut.
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Goryacheva, I. Y., und S. De Saeger. „Immunochemical detection of masked mycotoxins: A short review“. World Mycotoxin Journal 5, Nr. 3 (01.08.2012): 281–87. http://dx.doi.org/10.3920/wmj2012.1423.
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Mycotoxin derivatives that escape conventional analytical detection of parent (free) forms because their structure has been changed are designated masked mycotoxins. Masking phenomena are due to a defensive response of the host plant or can occur during food processing. Failure to detect masked mycotoxins will lead to a significant underestimation of the mycotoxin content of a particular sample. To date, mainly chromatographic methods were developed for masked mycotoxin determination and quantification. However, for fast screening, it is important to develop on-site methods for detection of masked and parent (free) forms. Although immunochemical methods could provide a simple and economical alternative to chromatography, their use for masked forms is only at the start of development. The key-point for antibody-based methods for masked mycotoxin determination is cross-reactivity of the specific antibody towards masked mycotoxins. If the antibody does not show meaningful affinity for masked forms, they will be latent, and the total content of this mycotoxin will be underestimated. If the antibody shows affinity for masked forms, the sum of free and masked forms will be determined. Currently, neither antibodies nor immuno-based methods were specifically developed for masked mycotoxins, but some enzyme-linked immunosorbent assay test-kits and immunoaffinity columns for mycotoxins were evaluated for their detection. This paper describes possible applications of antibody-based techniques for masked mycotoxin detection on the basis of recent literature.
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Slobodchikova, Irina, Reajean Sivakumar, Md Samiur Rahman und Dajana Vuckovic. „Characterization of Phase I and Glucuronide Phase II Metabolites of 17 Mycotoxins Using Liquid Chromatography—High-Resolution Mass Spectrometry“. Toxins 11, Nr. 8 (24.07.2019): 433. http://dx.doi.org/10.3390/toxins11080433.
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Routine mycotoxin biomonitoring methods do not include many mycotoxin phase I and phase II metabolites, which may significantly underestimate mycotoxin exposure especially for heavily metabolized mycotoxins. Additional research efforts are also needed to measure metabolites in vivo after exposure and to establish which mycotoxin metabolites should be prioritized for the inclusion during large-scale biomonitoring efforts. The objective of this study was to perform human in vitro microsomal incubations of 17 mycotoxins and systematically characterize all resulting metabolites using liquid chromatography–high-resolution mass spectrometry (LC-HRMS). The results obtained were then used to build a comprehensive LC-MS library and expand a validated 17-mycotoxin method for exposure monitoring to screening of additional 188 metabolites, including 100 metabolites reported for the first time. The final method represents one of the most comprehensive LC-HRMS methods for mycotoxin biomonitoring or metabolism/fate studies.
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Guerre, Philippe. „Mycotoxin and Gut Microbiota Interactions“. Toxins 12, Nr. 12 (04.12.2020): 769. http://dx.doi.org/10.3390/toxins12120769.
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The interactions between mycotoxins and gut microbiota were discovered early in animals and explained part of the differences in susceptibility to mycotoxins among species. Isolation of microbes present in the gut responsible for biotransformation of mycotoxins into less toxic metabolites and for binding mycotoxins led to the development of probiotics, enzymes, and cell extracts that are used to prevent mycotoxin toxicity in animals. More recently, bioactivation of mycotoxins into toxic compounds, notably through the hydrolysis of masked mycotoxins, revealed that the health benefits of the effect of the gut microbiota on mycotoxins can vary strongly depending on the mycotoxin and the microbe concerned. Interactions between mycotoxins and gut microbiota can also be observed through the effect of mycotoxins on the gut microbiota. Changes of gut microbiota secondary to mycotoxin exposure may be the consequence of the antimicrobial properties of mycotoxins or the toxic effect of mycotoxins on epithelial and immune cells in the gut, and liberation of antimicrobial peptides by these cells. Whatever the mechanism involved, exposure to mycotoxins leads to changes in the gut microbiota composition at the phylum, genus, and species level. These changes can lead to disruption of the gut barrier function and bacterial translocation. Changes in the gut microbiota composition can also modulate the toxicity of toxic compounds, such as bacterial toxins and of mycotoxins themselves. A last consequence for health of the change in the gut microbiota secondary to exposure to mycotoxins is suspected through variations observed in the amount and composition of the volatile fatty acids and sphingolipids that are normally present in the digesta, and that can contribute to the occurrence of chronic diseases in human. The purpose of this work is to review what is known about mycotoxin and gut microbiota interactions, the mechanisms involved in these interactions, and their practical application, and to identify knowledge gaps and future research needs.
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DRUSCH, S., und W. RAGAB. „Mycotoxins in Fruits, Fruit Juices, and Dried Fruits“. Journal of Food Protection 66, Nr. 8 (01.08.2003): 1514–27. http://dx.doi.org/10.4315/0362-028x-66.8.1514.
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This review gives an overview of the presence of mycotoxins in fruits. Although several mycotoxins occur in nature, very few (aflatoxins, ochratoxin A, patulin, Alternaria toxins) are regularly found in fruits. It has been shown that the presence of fungi on fruits is not necessarily associated with mycotoxin contamination. The formation of mycotoxins depends more on endogenous and environmental factors than fungal growth does. Mycotoxins may remain in fruits even when the fungal mycelium has been removed. Depending on the fruit and the mycotoxin, the diffusion of mycotoxins into the sound tissues of fruits may occur. The influence of the selection and storage of fruits and the influence of different processing steps involved in the production of fruit juices and dried fruits on possible mycotoxin contamination is described. It is shown that the careful selection, washing, and sorting of fruits is the most important factor in the reduction of mycotoxin contamination during the production of fruit juices. The processing of fruits does not result in the complete removal of mycotoxins.
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Arrúa, Andrea Alejandra, Juliana Moura Mendes, Pablo Arrúa, Francisco Paulo Ferreira, Gabriela Caballero, Cinthia Cazal, Man Mohan Kohli, Inocencia Peralta, Gabriela Ulke und Danilo Fernández Ríos. „Occurrence of Deoxynivalenol and Ochratoxin A in Beers and Wines Commercialized in Paraguay“. Toxins 11, Nr. 6 (30.05.2019): 308. http://dx.doi.org/10.3390/toxins11060308.
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Alcoholic beverages can be contaminated with mycotoxins. Ochratoxin A (OTA) is the most frequently detected mycotoxinin wine and is produced by several species of Aspergillus. This mycotoxin is nephrotoxic and carcinogenic. In beer, the most commonly identified mycotoxin is deoxynivalenol (DON). Ingestion of food contaminated with DON has been associated with adverse gastrointestinal effects. Despite the harmful effects of mycotoxins on health, there are no regulations regarding their limits in alcoholic beverages in Paraguay. Here we determine the presence of OTA and DON in wine and beer, respectively. Four commercial brands of wine and twenty-nine brands of craft and industrial beerwere tested by the Agra quant ELISA method. One brand of wine was positive for OTA and seven brands of beer (one of them craft) were positive for DON. The values found for both toxins are below the recommended maximum intake proposed by international standards. Giving the high consumption of these products in the country, regulations and monitoring systems mustbe established to check the maximum levels of mycotoxins allowed in alcoholic beverages.
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Martindah, Eny, und Sjamsul Bahri. „Mycotoxin Contamination in the Food Chain“. Indonesian Bulletin of Animal and Veterinary Sciences 26, Nr. 3 (06.02.2017): 115. http://dx.doi.org/10.14334/wartazoa.v26i3.1393.
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Mycotoxins contamination in animal feed is harmful to livestock and leads to residues, such as aflatoxin and its metabolites (aflatoxin M1, aflatoxicol, aflatoxin Q1 and aflatoxin P1) which are deposited in meat, milk, and eggs. The existence of mycotoxins has been widespread; and mycotoxin is the most important contaminant in the food chain because it has implications for human health. Mold growth and mycotoxin production mainly depend on the weather, such as warm temperatures (28-31°C) and high humidity (60-90%). Some types of mold can produce more than one type of mycotoxin and some mycotoxins can be produced by more than one species of fungi. Mycotoxins, especially aflatoxin, fumonisin, zearalenone, ochratoxin, deoxynivalenol, and T2 toxin present in feed and feedstuffs that have to be controlled. Mycotoxins are not only harmful to the health of consumers, but will also reduce the quality of the product that is contaminated, and cause economic losses. The risk of mycotoxin contamination in animal feed could be reduced by inhibiting the mould growth and toxin production, through crop rotation, using proper fungicides, and applying regulation of mycotoxins maximum limit in feed and food in order to prevent any danger to public health.
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Van, Egmond. „Mycotoxins: Risks, regulations and European co-operation“. Zbornik Matice srpske za prirodne nauke, Nr. 125 (2013): 7–20. http://dx.doi.org/10.2298/zmspn1325007v.
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Mycotoxins and mycotoxicises have been problems of the past and the present, but scientific attention for mycotoxins did not start until the early 1960?s. Nowa?days, many mycotoxins are known, and their occurrence in food and animal feed may cause various adverse effects on human and animal health, including carcinogenic, hepatotoxic, immunotoxic, nephrotoxic, neurotoxic, oestrogenic and teratogenic effects. Some important mycotoxins include the aflatoxins, ochratoxin A, the fumonisins and the trichothecenes, and their significance is briefly described. To protect human and animal health, many countries have enacted specific regulations for mycotoxins in food and animal feed. Risk assessment is a major factor for scientific underpinning of regulations, but other factors such as availability of adequate sampling and analysis procedures also play an important a role in the establishment of mycotoxin regulations. In addition, socio-economic factors such as cost-benefit considerations, trade issues and sufficiency of food supply are equally important in the decision-taking process to come to meaningful regulations. Nowadays, more than 100 countries have formal mycotoxin regulations for food and feed. The mycotoxin regulations are the most stringent in the EU, where various organizations and pan-European networks contribute to combat the mycotoxin problem. It is to be expected that mycotoxins will stay with us in the future and climate change might have a negative influence in this respect. Several possibilities exist to mitigate the problems caused by mycotoxins. In particular prevention of mould growth and mycotoxin formation is key to the control of mycotoxins.
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Dell’Orto, V., G. Baldi und F. Cheli. „Mycotoxins in silage: checkpoints for effective management and control“. World Mycotoxin Journal 8, Nr. 5 (30.09.2015): 603–17. http://dx.doi.org/10.3920/wmj2014.1866.
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Silage has a substantial role in ruminant nutrition. Silages as a source of mycotoxigenic fungi and mycotoxins merit attention. Fungal growth and mycotoxin production before and during storage are a well-known phenomenon, resulting in reduced nutritional value and a possible risk factor for animal health. Mycotoxin co-contamination seems to be unavoidable under current agricultural and silage-making practices. Multi-mycotoxin contamination in silages is of particular concern due to the potential additive or synergistic effects on animals. In regard to managing the challenge of mycotoxins in silages, there are many factors with pre- and post-harvest origins to take into account. Pre-harvest events are predominantly dictated by environmental factors, whereas post-harvest events can be largely controlled by the farmer. An effective mycotoxin management and control programme should be integrated and personalised to each farm at an integrative level throughout the silage production chain. Growing crops in the field, silage making practices, and the feed out phase must be considered. Economical and straightforward silage testing is critical to reach a quick and sufficiently accurate diagnosis of silage quality, which allows for ‘in field decision-making’ with regard to the rapid diagnosis of the quality of given forage for its safe use as animal feed. Regular sampling and testing of silage allow picking up any variations in mycotoxin contamination. The use of rapid methods in the field represents future challenges. Moreover, a proper nutritional intervention needs to be considered to manage mycotoxin-contaminated silages. At farm level, animals are more often exposed to moderate amounts of several mycotoxins rather than to high levels of a single mycotoxin, resulting more frequently in non-specific digestive and health status impairment. Effective dietary strategies to promote rumen health, coupled with the administration of effective and broad-spectrum mycotoxin detoxifiers, are essential to minimise the negative impact of mycotoxins.
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Zhao, Zitong, Zhenzhen Zhang, Haoxiang Zhang und Zhihong Liang. „Small Peptides in the Detection of Mycotoxins and Their Potential Applications in Mycotoxin Removal“. Toxins 14, Nr. 11 (16.11.2022): 795. http://dx.doi.org/10.3390/toxins14110795.
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Mycotoxins pose significant risks to humans and livestock. In addition, contaminated food- and feedstuffs can only be discarded, leading to increased economic losses and potential ecological pollution. Mycotoxin removal and real-time toxin level monitoring are effective approaches to solve this problem. As a hot research hotspot, small peptides derived from phage display peptide libraries, combinatorial peptide libraries, and rational design approaches can act as coating antigens, competitive antigens, and anti-immune complexes in immunoassays for the detection of mycotoxins. Furthermore, as a potential approach to mycotoxin degradation, small peptides can mimic the natural enzyme catalytic site to construct artificial enzymes containing oxidoreductases, hydrolase, and lyase activities. In summary, with the advantages of mature synthesis protocols, diverse structures, and excellent biocompatibility, also sharing their chemical structure with natural proteins, small peptides are widely used for mycotoxin detection and artificial enzyme construction, which have promising applications in mycotoxin degradation. This paper mainly reviews the advances of small peptides in the detection of mycotoxins, the construction of peptide-based artificial enzymes, and their potential applications in mycotoxin control.
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Vandicke, Jonas, Katrien De Visschere, Siska Croubels, Sarah De Saeger, Kris Audenaert und Geert Haesaert. „Mycotoxins in Flanders’ Fields: Occurrence and Correlations with Fusarium Species in Whole-Plant Harvested Maize“. Microorganisms 7, Nr. 11 (18.11.2019): 571. http://dx.doi.org/10.3390/microorganisms7110571.
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Mycotoxins are well-known contaminants of several food- and feedstuffs, including silage maize for dairy cattle. Climate change and year-to-year variations in climatic conditions may cause a shift in the fungal populations infecting maize, and therefore alter the mycotoxin load. In this research, 257 maize samples were taken from fields across Flanders, Belgium, over the course of three years (2016–2018) and analyzed for 22 different mycotoxins using a multi-mycotoxin liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. DNA of Fusarium graminearum, F. culmorum and F. verticillioides was quantified using the quantitative polymerase chain reaction (qPCR). Multi-mycotoxin contamination occurred frequently, with 47% of samples containing five or more mycotoxins. Nivalenol (NIV) was the most prevalent mycotoxin, being present in 99% of the samples, followed by deoxynivalenol (DON) in 86% and zearalenone (ZEN) in 50% of the samples. Fumonisins (FUMs) were found in only 2% of the samples in the wet, cold year of 2016, but in 61% in the extremely hot and dry year of 2018. Positive correlations were found between DON and NIV and between F. graminearum and F. culmorum, among others. FUM concentrations were not correlated with any other mycotoxin, nor with any Fusarium sp., except F. verticillioides. These results show that changing weather conditions can influence fungal populations and the corresponding mycotoxin contamination of maize significantly, and that multi-mycotoxin contamination increases the risk of mycotoxicosis in dairy cattle.
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McElhinney, C., M. Danaher, C. Elliott und P. O’Kiely. „Mycotoxin occurrence on baled and pit silages collected in Co. Meath“. Irish Journal of Agricultural and Food Research 54, Nr. 2 (01.12.2015): 87–97. http://dx.doi.org/10.1515/ijafr-2015-0010.
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AbstractRecent studies of baled silages produced in Ireland have identified considerable filamentous fungal contamination. Many of these fungi are toxigenic, capable of producing secondary metabolites, namely mycotoxins. Mycotoxins are potentially detrimental to livestock health and some can pose a risk to consumers of animal products. Baled (n=20) and pit (n=18) silages from a sample of farms (n=38) in Co. Meath were examined to assess the occurrence of mycotoxins and ascertain whether sampling position within the pit silos (feed face vs. 3 m behind the feed face) has an effect on mycotoxin content or other chemical compositional variables. Of the 20 mycotoxins assayed, baled silages contained [mean of positive values (no. of values in mean)] mycotoxin concentrations (μg/kg dry matter) of beauvericin 36 (2), enniatin (enn.) A 9.3 (3), enn. A154 (8), enn. B 351 (9), enn. B1136 (10), mycophenolic acid (MPA) 11,157 (8) and roquefortine C (Roq. C) 1037 (8) and pit silages contained beauvericin 25 (2) enn. A118 (2), enn. B 194 (9), enn. B157 (3), MPA 287 (6), Roq. C 3649 (6) and zearalenone 76 (1). There was no difference (P>0.05) observed in the mycotoxin concentrations between baled and pit silages, and 11 of the 20 mycotoxins assayed were below the limits of detection. The position of sampling had no effect on the mycotoxin concentration detected in pit silages. It is concluded that mycotoxin concentrations detected in these pit and baled silages in Co. Meath did not exceed EU regulation or guidance limits, and that similar chemical composition and mycotoxin concentration values occurred at the pit silage feed face and 3 m behind this feed face.
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Barajas-Ramírez, Jahir Antonio, Delfino Alejandro Moncada-Abaunza und María Guadalupe Gómez-Espinoza. „Mycotoxins in foods, from the field to the plate: a review“. International Food Research Journal 28, Nr. 2 (01.04.2021): 230–47. http://dx.doi.org/10.47836/ifrj.28.2.02.
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Mycotoxins are secondary metabolites produced by some fungal species, mainly from the genera Alternaria, Aspergillus, Fusarium, and Penicillium. Mycotoxins can be found in raw materials and processed foods. High intake of mycotoxins in short time periods will generate outbreaks of mycotoxicosis distinguished by physical discomfort or even death. Chronic consumption of mycotoxins can cause several important illnesses. Due to the substantial health risk of mycotoxin intake, several organisations have recommended the maximum allowable limits in foods. Since differences in the values suggested across organisations affect the risk of populations ingesting these compounds, the criteria must be unified. Mycotoxins are generally highly thermostable. Operations commonly applied during food processing such as frying and roasting have variable effects in reducing the mycotoxin content. The use of probiotics to transform mycotoxins into minor toxic compounds is a promising alternative reduction measure. The complete elimination of mycotoxins in foods appears practically impossible. Therefore, good agronomic practices are essential to avoid the growth of mycotoxin-producing fungi in raw materials. Global climate change is a relevant issue due to the changes in rainfall, humidity, and temperature patterns worldwide could stimulate the growth of fungi in broader regions, thus increasing the risk of mycotoxin presence in foods and subsequent consumption. Therefore, increasing research and development in innovative methods for the elimination or reduction of mycotoxins in foods is essential.
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Pleadin, Jelka, Tina Lešić, Dragan Milićević, Ksenija Markov, Bojan Šarkanj, Nada Vahčić, Ivana Kmetič und Manuela Zadravec. „Pathways of Mycotoxin Occurrence in Meat Products: A Review“. Processes 9, Nr. 12 (25.11.2021): 2122. http://dx.doi.org/10.3390/pr9122122.
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Documented cases of mycotoxin occurrence in meat products call for further research into potential contamination sources, especially given an ever more increasing consumption of these nutritionally rich products. These foodstuffs can be contaminated with mycotoxins through three pathways: contaminated spices and other raw materials, mycotoxin-producing moulds present on the surface of dry-cured meat products, and carry-over effect from farm animals exposed to contaminated feed. In order to establish meat products’ mycotoxin contamination more precisely, the concentrations of all mycotoxins of relevance for these products should be determined. This manuscript reviews data on major mycotoxins present in different types of meat products, and discusses the contamination pathways, contamination levels and control & preventative measures.
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Gruber-Dorninger, Christiane, Timothy Jenkins und Gerd Schatzmayr. „Global Mycotoxin Occurrence in Feed: A Ten-Year Survey“. Toxins 11, Nr. 7 (27.06.2019): 375. http://dx.doi.org/10.3390/toxins11070375.
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Mycotoxins contaminating animal feed can exert toxic effects in animals and be transferred into animal products. Therefore, mycotoxin occurrence in feed should be monitored. To this end, we performed a large-scale global survey of mycotoxin contamination in feed and assessed regional differences and year-to-year variation of mycotoxin occurrence. Concentrations of aflatoxin B1, zearalenone, fumonisins, ochratoxin A, deoxynivalenol, and T-2 toxin were analyzed in 74,821 samples of feed and feed raw materials (e.g., maize, wheat, soybean) collected from 100 countries from 2008 to 2017. In total, 88% of the samples were contaminated with at least one mycotoxin. Mycotoxin occurrence showed distinct regional trends and climate was a key determinant governing these trends. In most regions, the majority of samples complied with maximum levels and guidance values for mycotoxins in animal feed that are in effect in the European Union. However, 41.1%, 38.5%, and 20.9% of samples from South Asia, Sub-Saharan Africa, and Southeast Asia, respectively, exceeded the maximum level for aflatoxin B1 (20 µg/kg). In several regions, mycotoxin concentrations in maize showed a pronounced year-to-year variation that could be explained by rainfall or temperature during sensitive periods of grain development. A large fraction of samples (64%) was co-contaminated with ≥ 2 mycotoxins. Most frequently observed mycotoxin mixtures were combinations of deoxynivalenol, zearalenone, and fumonisins, as well as fumonisins and aflatoxin B1. Deoxynivalenol and zearalenone concentrations were correlated in maize and wheat. In conclusion, according to an extensive global survey, mycotoxin (co-)contamination of animal feed is common, shows regional trends, and is governed in part by climate and weather.
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Vandicke, Jonas, Katrien De Visschere, Maarten Ameye, Siska Croubels, Sarah De Saeger, Kris Audenaert und Geert Haesaert. „Multi-Mycotoxin Contamination of Maize Silages in Flanders, Belgium: Monitoring Mycotoxin Levels from Seed to Feed“. Toxins 13, Nr. 3 (11.03.2021): 202. http://dx.doi.org/10.3390/toxins13030202.
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Maize silage, which in Europe is the main feed for dairy cattle in winter, can be contaminated by mycotoxins. Mycotoxigenic Fusarium spp. originating from field infections may survive in badly sealed silages or re-infect at the cutting edge during feed-out. In this way, mycotoxins produced in the field may persist during the silage process. In addition, typical silage fungi such as Penicillium spp. and Aspergillus spp. survive in silage conditions and produce mycotoxins. In this research, 56 maize silages in Flanders were sampled over the course of three years (2016–2018). The concentration of 22 different mycotoxins was investigated using a multi-mycotoxin liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, and the presence of DNA of three Fusarium spp. (F. graminearum, F. culmorum and F. verticillioides) was analyzed in a selection of these samples using quantitative polymerase chain reaction (qPCR). Every maize silage contained at least two different mycotoxins. Nivalenol (NIV) and deoxynivalenol (DON) were the most prevalent (both in 97.7% of maize silages), followed by ENN B (88.7%). Concentrations often exceeded the EU recommendations for DON and zearalenone (ZEN), especially in 2017 (21.3% and 27.7% of the maize silages, respectively). No correlations were found between fungal DNA and mycotoxin concentrations. Furthermore, by ensiling maize with a known mycotoxin load in a net bag, the mycotoxin contamination could be monitored from seed to feed. Analysis of these net bag samples revealed that the average concentration of all detected mycotoxins decreased after fermentation. We hypothesize that mycotoxins are eluted, degraded, or adsorbed during fermentation, but certain badly preserved silages are prone to additional mycotoxin production during the stable phase due to oxygen ingression, leading to extremely high toxin levels.
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Chilaka, Cynthia Adaku, Jude Ejikeme Obidiegwu, Augusta Chinenye Chilaka, Olusegun Oladimeji Atanda und Angela Mally. „Mycotoxin Regulatory Status in Africa: A Decade of Weak Institutional Efforts“. Toxins 14, Nr. 7 (29.06.2022): 442. http://dx.doi.org/10.3390/toxins14070442.
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Food safety problems are a major hindrance to achieving food security, trade, and healthy living in Africa. Fungi and their secondary metabolites, known as mycotoxins, represent an important concern in this regard. Attempts such as agricultural, storage, and processing practices, and creation of awareness to tackle the menace of fungi and mycotoxins have yielded measurable outcomes especially in developed countries, where there are comprehensive mycotoxin legislations and enforcement schemes. Conversely, most African countries do not have mycotoxin regulatory limits and even when available, are only applied for international trade. Factors such as food insecurity, public ignorance, climate change, poor infrastructure, poor research funding, incorrect prioritization of resources, and nonchalant attitudes that exist among governmental organisations and other stakeholders further complicate the situation. In the present review, we discuss the status of mycotoxin regulation in Africa, with emphasis on the impact of weak mycotoxin legislations and enforcement on African trade, agriculture, and health. Furthermore, we discuss the factors limiting the establishment and control of mycotoxins in the region.
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Zhang, W. W., Z. M. Ye, Y. Jin, S. Y. Wang, L. S. Zhang und X. F. Pei. „Management of mycotoxin contamination in food and feed in China“. World Mycotoxin Journal 7, Nr. 1 (01.01.2014): 53–62. http://dx.doi.org/10.3920/wmj2013.1553.
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Mycotoxins have a significant impact on human and animal health as well as economy and international trade. A number of steps have been taken to minimise mycotoxin contamination worldwide. China, one of the largest importers and exporters of food and animal feed, has implemented management strategies to protect consumers from mycotoxins and ensure safe trading of food and feed. The development and status of these management strategies are of interest to many stakeholders, however, no comprehensive review of these strategies has been published to date. The objective of this article is to review these strategies, including associated regulations, risk assessments, contamination monitoring practices, and processes for the supervision and management of associated production, distribution and consumption chains. There are 49 mycotoxin-related regulations in China; these include maximum levels for seven mycotoxins, standard methods for detecting 17 mycotoxins, and a code of practice for the prevention and reduction of mycotoxin contamination in cereals. Twelve mycotoxins found in daily food are covered by the Chinese contamination monitoring network. A new risk assessment organisation is required to systematically implement and manage food safety risk assessments in China. In addition, self-control by companies and daily supervisions and inspections by government departments are quite effective in preventing the consumption of mycotoxin-contaminated food and feed. This article provides information to all those who wish to understand more about the current safety management systems for combating mycotoxin contamination of food and feed in China.
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Degen, G. „Tools for investigating workplace-related risks from mycotoxin exposure“. World Mycotoxin Journal 4, Nr. 3 (01.08.2011): 315–27. http://dx.doi.org/10.3920/wmj2011.1295.
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There is growing recognition and interest in the role of mycotoxins as health hazards in the workplace. Examples will illustrate what we know about certain mycotoxins in some occupational settings and what we need to know to make further progress in assessing their impact on human health. A range of mycotoxins has been detected in different workplaces, e.g. in agricultural and food processing facilities, greenhouses, and the waste management sector. Their occurrence, mainly in dust from different raw materials or processed products, is indicative of a potential health hazard. However, assessing risks for workplace-related mycotoxin exposures remains a challenging task for several reasons, including uncertainties with regard to the transfer from contaminated material into air (inhalable mycotoxin concentrations) and/or the toxin fraction absorbed upon dermal contact or after respiratory intake. Human biomonitoring studies can considerably reduce these uncertainties, and serve to assess workplace-related exposures (in addition to dietary mycotoxin intake). These studies require not only sensitive methods for analysis of mycotoxins and/or their metabolites in blood or urine (biomarkers of exposure) in a cohort of workers, but also data on the levels/range of these biomarkers in non-occupationally exposed persons to account for exposures resulting from oral intake of mycotoxin-contaminated food (dietary 'background'). Biomonitoring methods were first developed for aflatoxin B1, then for ochratoxin A, and more recently for deoxynivalenol and for fumonisin B. But, there are no such methods for many other important mycotoxins. So far, only a small number of biomonitoring studies have addressed the question whether occupational mycotoxin exposures (by inhalation) add significantly to those from dietary exposure to mycotoxins, as observed in the general population. Therefore, a risk assessment is hampered by major uncertainties regarding the true impact of occupational mycotoxin exposures. Human biomonitoring (with biomarkers of exposure and/or effect) is considered a valuable instrument, and should be developed further for mycotoxins of relevance in the workplace.
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Hao, Wei, Shu Guan, Anping Li, Jinyong Wang, Gang An, Ursula Hofstetter und Gerd Schatzmayr. „Mycotoxin Occurrence in Feeds and Raw Materials in China: A Five-Year Investigation“. Toxins 15, Nr. 1 (11.01.2023): 63. http://dx.doi.org/10.3390/toxins15010063.
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Mycotoxins are ubiquitously present in feeds and raw materials and can exert toxicity on animals and humans. Therefore, mycotoxin occurrence should be monitored. We report here a multi-mycotoxin survey of feed samples in China from 2017 to 2021. Concentrations of aflatoxins, trichothecenes type B, fumonisins, and zearalenone were determined in a total of 9392 samples collected throughout China. Regional differences and year-to-year variation of mycotoxin occurrence were also assessed in new-season corn. Generally, Fusarium mycotoxins were prevalent, while mycotoxin contamination in each feed commodity showed a distinct pattern, e.g., wheat and bran were typically affected by trichothecenes type B, peanut meals were highly susceptible to aflatoxins, and finished feeds exhibited a comparatively high prevalence of all mycotoxins. In new-season corn, trichothecenes type B and fumonisins were most prevalent, with positive rates of 84.04% and 87.16%, respectively. Regions exhibited different patterns of mycotoxin occurrence. The Anhui and Jiangsu provinces of East China exhibited a high prevalence and concentrations of aflatoxins with a positive rate and a positive average of 82.61% and 103.08 μg/kg, respectively. Central China obtained high fumonisins levels of 4707.84 μg/kg. Trichothecenes type B and zearalenone occurred more frequently in temperate regions of Northeast China, and their positive rates reached 94.99% and 55.67%, respectively. In these regions, mycotoxin concentrations in new-season corn exhibited pronounced year-to-year variations and this could be due to the unusual changes of rainfall or temperature during sensitive periods of corn growing. A large fraction of new-season corn samples contained multiple mycotoxins with two to three classes (75.42%), and the most frequently observed co-contaminants were the combination of trichothecenes type B and fumonisins (73.52%). Trichothecenes type B and zearalenone concentrations were highly positively correlated with a coefficient of 0.775. In conclusion, mycotoxins contamination and co-contamination of feeds are common. Mycotoxin contamination in new-season corn exhibited regional patterns and year-to-year variations, with climate and weather conditions as determinant factors.
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Voznyakovskii A.P., Karmanov A.P., Kocheva L.S., Neverovskaya A. Yu., Vozniakovskii A.A., Kanarskii A. V., Semenov E. I. und Kidalov S.V. „Few-Layer Graphene Structures as a Promising Mycotoxin Sorbent“. Technical Physics 92, Nr. 7 (2022): 792. http://dx.doi.org/10.21883/tp.2022.07.54472.31-22.
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It has been experimentally established that samples of low-layer graphene, synthesized by carbonization of plant materials (lignin, cellulose, and spruce bark) under conditions of self-propagating high-temperature synthesis, are effective sorbents for mycotoxin T-2 under conditions simulating the environment in the gastrointestinal tract of mammals, and are capable of irreversibly sorb at least 94.6% of mycotoxin with a sorption capacity of 1 mg of mycotoxins per 1 g of sorbent. Key words: few-layer graphene, self-propagating high-temperature synthesis, specific surface area, mycotoxin sorption. Keywords: few-layer graphene, self-propagating high-temperature synthesis, specific surface, sorption of mycotoxins.
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N., Syamilah, Nurul Afifah S., Effarizah M.E. und Norlia M. „Mycotoxins and mycotoxigenic fungi in spices and mixed spices: a review“. Food Research 6, Nr. 4 (03.07.2022): 30–46. http://dx.doi.org/10.26656/fr.2017.6(4).971.
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Mycotoxins are secondary metabolites produced by fungi mainly from the genus Aspergillus, Penicillium, Fusarium, and Alternaria. The occurrence of mycotoxin contamination has been reported in various types of food, including spices such as chilli, black pepper, white pepper, cumin, coriander seed, and the ground mix spices. Aflatoxins (AFs) and ochratoxin A (OTA) are the primary mycotoxins in spices produced by Aspergillus spp. and Penicillium spp. Among these spices, chilli is more susceptible to the invasion of these mycotoxigenic fungi, especially during prolonged storage and inappropriate storage conditions, resulting in mycotoxin production. The storage conditions, processing methods, and handling practices of spices may affect the growth of fungi and subsequent mycotoxin production. This paper reviewed mycotoxigenic fungi and mycotoxin contamination in spices, the impact on humans, and the regulatory limit adopted by many countries worldwide.
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Nan, Mina, Huali Xue und Yang Bi. „Contamination, Detection and Control of Mycotoxins in Fruits and Vegetables“. Toxins 14, Nr. 5 (27.04.2022): 309. http://dx.doi.org/10.3390/toxins14050309.
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Mycotoxins are secondary metabolites produced by pathogenic fungi that colonize fruits and vegetables either during harvesting or during storage. Mycotoxin contamination in fruits and vegetables has been a major problem worldwide, which poses a serious threat to human and animal health through the food chain. This review systematically describes the major mycotoxigenic fungi and the produced mycotoxins in fruits and vegetables, analyzes recent mycotoxin detection technologies including chromatography coupled with detector (i.e., mass, ultraviolet, fluorescence, etc.) technology, electrochemical biosensors technology and immunological techniques, as well as summarizes the degradation and detoxification technologies of mycotoxins in fruits and vegetables, including physical, chemical and biological methods. The future prospect is also proposed to provide an overview and suggestions for future mycotoxin research directions.
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Čolović, Radmilo, Nikola Puvača, Federica Cheli, Giuseppina Avantaggiato, Donato Greco, Olivera Đuragić, Jovana Kos und Luciano Pinotti. „Decontamination of Mycotoxin-Contaminated Feedstuffs and Compound Feed“. Toxins 11, Nr. 11 (25.10.2019): 617. http://dx.doi.org/10.3390/toxins11110617.
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Mycotoxins are known worldwide as fungus-produced toxins that adulterate a wide heterogeneity of raw feed ingredients and final products. Consumption of mycotoxins-contaminated feed causes a plethora of harmful responses from acute toxicity to many persistent health disorders with lethal outcomes; such as mycotoxicosis when ingested by animals. Therefore, the main task for feed producers is to minimize the concentration of mycotoxin by applying different strategies aimed at minimizing the risk of mycotoxin effects on animals and human health. Once mycotoxins enter the production chain it is hard to eliminate or inactivate them. This paper examines the most recent findings on different processes and strategies for the reduction of toxicity of mycotoxins in animals. The review gives detailed information about the decontamination approaches to mitigate mycotoxin contamination of feedstuffs and compound feed, which could be implemented in practice.
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Lootens, Orphélie, An Vermeulen, Siska Croubels, Sarah De Saeger, Jan Van Bocxlaer und Marthe De Boevre. „Possible Mechanisms of the Interplay between Drugs and Mycotoxins—Is There a Possible Impact?“ Toxins 14, Nr. 12 (14.12.2022): 873. http://dx.doi.org/10.3390/toxins14120873.
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Mycotoxin contamination is a global food safety issue leading to major public health concerns. Repeated exposure to multiple mycotoxins not only has repercussions on human health but could theoretically also lead to interactions with other xenobiotic substances—such as drugs—in the body by altering their pharmacokinetics and/or pharmacodynamics. The combined effects of chronic drug use and mycotoxin exposure need to be well understood in order to draw valid conclusions and, in due course, to develop guidelines. The aim of this review is to focus on food contaminants, more precisely on mycotoxins, and drugs. First, a description of relevant mycotoxins and their effects on human health and metabolism is presented. The potential for interactions of mycotoxins with drugs using in vitro and in vivo animal experiments is summarized. Predictive software tools for unraveling mycotoxin–drug interactions are proposed and future perspectives on this emerging topic are highlighted with a view to evaluate associated risks and to focus on precision medicine. In vitro and in vivo animal studies have shown that mycotoxins affect CYP450 enzyme activity. An impact from drugs on mycotoxins mediated via CYP450-enzymes is plausible; however, an impact of mycotoxins on drugs is less likely considering the much smaller dose exposure to mycotoxins. Drugs that are CYP450 perpetrators and/or substrates potentially influence the metabolism of mycotoxins, metabolized via these CYP450 enzymes. To date, very little research has been conducted on this matter. The only statistically sound reports describe mycotoxins as victims and drugs as perpetrators in interactions; however, more analysis on mycotoxin–drug interactions needs to be performed.
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Er Demirhan, Buket, und Burak Demirhan. „The Investigation of Mycotoxins and Enterobacteriaceae of Cereal-Based Baby Foods Marketed in Turkey“. Foods 10, Nr. 12 (07.12.2021): 3040. http://dx.doi.org/10.3390/foods10123040.
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In this study, a total of 85 cereal-based baby foods with or without milk (four different brands; A, B, C, and D) collected from Ankara local markets, Turkey were analyzed for mycotoxins, total aerobic mesophilic bacteria (TAMB), and Enterobacteriaceae contamination. Baby foods were analyzed for 12 toxicological important mycotoxins such as aflatoxin B1, B2, G1, and G2; fumonisin B1 and B2; ochratoxin A; sterigmatocystin (STE); deoxynivalenol (DON); zearalenone (ZON); and T-2 toxin and HT-2 toxin by LC-MS/MS multi-mycotoxin method. In addition to these mycotoxins, the presence of aflatoxin M1 (AFM1) was investigated in baby foods containing milk. The classical culture method was used for microbiological analysis. Consequently, at least one mycotoxin was detected in 69.41% of the total samples. The most frequently detected mycotoxins were STE (34.12%) and HT-2 (34.12%). However, AFM1 was not detected in any of the baby foods containing milk. Also, TAMB and Enterobacteriaceae were isolated from 30.59% and 10.59% of samples, respectively. As a result, it was determined that the mycotoxin levels in the analyzed samples were in accordance with the mycotoxin levels specified in the Turkish Food Codex.
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Pei, Xingyao, Wenjuan Zhang, Haiyang Jiang, Dingkuo Liu, Xinyu Liu, Liuan Li, Cun Li, Xilong Xiao, Shusheng Tang und Daowen Li. „Food-Origin Mycotoxin-Induced Neurotoxicity: Intend to Break the Rules of Neuroglia Cells“. Oxidative Medicine and Cellular Longevity 2021 (28.09.2021): 1–14. http://dx.doi.org/10.1155/2021/9967334.
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Mycotoxins are key risk factors in human food and animal feed. Most of food-origin mycotoxins could easily enter the organism and evoke systemic toxic effects, such as aflatoxin B1 (AFB1), ochratoxin A (OTA), T-2 toxin, deoxynivalenol (DON), zearalenone (ZEN), fumonisin B1 (FB1), and 3-nitropropionic acid (3-NPA). For the last decade, the researches have provided much evidences in vivo and in vitro that the brain is an important target organ on mycotoxin-mediated neurotoxic phenomenon and neurodegenerative diseases. As is known to all, glial cells are the best regulator and defender of neurons, and a few evaluations about the effects of mycotoxins on glial cells such as astrocytes or microglia have been conducted. The fact that mycotoxin contamination may be a key factor in neurotoxicity and glial dysfunction is exactly the reason why we reviewed the activation, oxidative stress, and mitochondrial function changes of glial cells under mycotoxin infection and summarized the mycotoxin-mediated glial cell proliferation disorders, death pathways, and inflammatory responses. The purpose of this paper is to analyze various pathways in which common food-derived mycotoxins can induce glial toxicity and provide a novel perspective for future research on the neurodegenerative diseases.
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Conte, Giuseppe, Marco Fontanelli, Francesca Galli, Lorenzo Cotrozzi, Lorenzo Pagni und Elisa Pellegrini. „Mycotoxins in Feed and Food and the Role of Ozone in Their Detoxification and Degradation: An Update“. Toxins 12, Nr. 8 (30.07.2020): 486. http://dx.doi.org/10.3390/toxins12080486.
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Mycotoxins are secondary metabolites produced by some filamentous fungi, which can cause toxicity in animal species, including humans. Because of their high toxicological impacts, mycotoxins have received significant consideration, leading to the definition of strict legislative thresholds and limits in many areas of the world. Mycotoxins can reduce farm profits not only through reduced crop quality and product refusal, but also through a reduction in animal productivity and health. This paper briefly addresses the impacts of mycotoxin contamination of feed and food on animal and human health, and describes the main pre- and post-harvest systems to control their levels, including genetic, agronomic, biological, chemical, and physical methods. It so highlights (i) the lack of effective and straightforward solutions to control mycotoxin contamination in the field, at pre-harvest, as well as later post-harvest; and (ii) the increasing demand for novel methods to control mycotoxin infections, intoxications, and diseases, without leaving toxic chemical residues in the food and feed chain. Thus, the broad objective of the present study was to review the literature on the use of ozone for mycotoxin decontamination, proposing this gaseous air pollutant as a powerful tool to detoxify mycotoxins from feed and food.
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Horky, Pavel, Sylvie Skalickova, Daria Baholet und Jiri Skladanka. „Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins“. Nanomaterials 8, Nr. 9 (14.09.2018): 727. http://dx.doi.org/10.3390/nano8090727.
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Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The occurrence of mycotoxins in food and feed causes negative health impacts on both humans and animals. Clay binders, yeast cell walls, or antioxidant additives are the most widely used products for mycotoxin elimination to reduce their impact. Although conventional methods are constantly improving, current research trends are looking for innovative solutions. Nanotechnology approaches seem to be a promising, effective, and low-cost way to minimize the health effects of mycotoxins. This review aims to shed light on the critical knowledge gap in mycotoxin elimination by nanotechnology. There are three main strategies: mold inhibition, mycotoxin adsorption, and reducing the toxic effect via nanoparticles. One of the most promising methods is the use of carbon-based nanomaterials. Graphene has been shown to have a huge surface and high binding capacity for mycotoxins. Attention has also been drawn to polymeric nanoparticles; they could substitute adsorbents or enclose any substance, which would improve the health status of the organism. In light of these findings, this review gives new insights into possible future research that might overcome challenges associated with nanotechnology utilization for mycotoxin elimination from agricultural products.
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Zhu, Cheng-Cheng, Yan-Jun Hou, Jun Han, Hong-Lin Liu, Xiang-Shun Cui, Nam-Hyung Kim und Shao-Chen Sun. „Effect of Mycotoxin-Containing Diets on Epigenetic Modifications of Mouse Oocytes by Fluorescence Microscopy Analysis“. Microscopy and Microanalysis 20, Nr. 4 (09.05.2014): 1158–66. http://dx.doi.org/10.1017/s1431927614000919.
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AbstractMycotoxins, such as aflatoxin (AF), fumonisin B1, zearalenone (ZEA), and deoxynivalenol (DON), are commonly found in many food commodities. Mycotoxins have been shown to increase DNA methylation levels in a human intestinal cell line. We previously showed that the developmental competence of oocytes was affected in mice that had been fed a mycotoxin-containing diet. In this study, we explored possible mechanisms of low mouse oocyte developmental competence after mycotoxin treatment in an epigenetic modification perspective. Mycotoxin-contaminated maize (DON at 3,875μg/kg, ZEA at 1,897μg/kg, and AF at 806μg/kg) was included in diets at three different doses (mass percentage: 0, 15, and 30%) and fed to mice for 4 weeks. The fluorescence intensity analysis showed that the general DNA methylation levels increased in oocytes from high dose mycotoxin-fed mice. Mouse oocyte histone methylation was also altered. H3K9me3 and H4K20me3 level increased in oocytes from mycotoxin-fed mice, whereas H3K27me3 and H4K20me2 level decreased in oocytes from mycotoxin-fed mice. Thus, our results indicate that naturally occurring mycotoxins have effects on epigenetic modifications in mouse oocytes, which may be one of the reasons for reduced oocyte developmental competence.
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Ejeh Augustine O und Abah Emmanuel A. „Assessment of five major mycotoxins in millet and sorghum in Benue south senatorial district, Benue State, Nigeria“. World Journal of Advanced Research and Reviews 16, Nr. 2 (30.11.2022): 1066–71. http://dx.doi.org/10.30574/wjarr.2022.16.2.1255.
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Millet and sorghum grain are not consumed soon after harvest but often stored for many months to be sold or consumed later. Extremely high and low temperatures, humidity, improper handling and improper storage have been contributory to mycotoxin production by filamentous fungi in most food crops either on the field, in storage or during transportation. This study considered the assessment of mycotoxin in indigenous millet and sorghum produced by farmers Benue South Senatorial District of Benue state. Mycotoxin Extraction and Evaluation of Deoxynivalenol (DON) by HPLC were carried out. The result obtained from the different analysis showed mycotoxin occurrence in both food samples analysed at varying concentrations. Incidences of all five mycotoxins were determined in both food samples up to 94.9%. Data obtained from the analysis (Tables 1 and 2) showed the occurence of aflatoxins and ocratoxin A in both millet and sorghum samples in comparison to the other three mycotoxins. From the result above the percentage occurrence of various fungi species are reported thus; Aspergillus spp (41.67%), Fusarium spp. (27.08%), Mucor spp. (12.5%), Penicillium spp. (10.42%) and Rhizopus spp. (8.33%). Aspergillus spp occurred in all three zones with higher frequency and are known producers of mycotoxins such as aflatoxin, sterigmatocystin and ochratoxin. The high incidence of both DON and ZEA in the food commodities analysed is a cause for concern and reason for more research into other mycotoxins contamination of Nigerian food commodities as well control strategies in order to combat mycotoxin contamination.
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Ruscito, Annamaria, McKenzie Smith, Daniel N. Goudreau und Maria C. DeRosa. „Current Status and Future Prospects for Aptamer-Based Mycotoxin Detection“. Journal of AOAC INTERNATIONAL 99, Nr. 4 (01.07.2016): 865–77. http://dx.doi.org/10.5740/jaoacint.16-0114.
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Abstract Aptamers are single-stranded oligonucleotides with the ability to bind tightly and selectively to a target analyte. High-affinity and specific aptamers for a variety of mycotoxins have been reported over the past decade. Increasingly, these molecular recognition elements are finding applications in biosensors and assays for the detection of mycotoxins in a variety of complex matrixes. This review article highlights the mycotoxin aptamers that are available for mycotoxin detection and the array of biosensing platforms into which they have been incorporated. Key advantages that aptamers have over analogous technology, and areas in which these advantages may be applied for the benefit of practical mycotoxin detection, are also discussed.
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Perczak, Adam, Piotr Goliński, Marcin Bryła und Agnieszka Waśkiewicz. „The efficiency of lactic acid bacteria against pathogenic fungi and mycotoxins“. Archives of Industrial Hygiene and Toxicology 69, Nr. 1 (01.03.2018): 32–45. http://dx.doi.org/10.2478/aiht-2018-69-3051.
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Abstract Mycotoxins are produced by some fungal species of the genera Aspergillus, Penicillium, and Fusarium and are common contaminants of a wide range of food commodities. Numerous strategies are used to minimise fungal growth and mycotoxin contamination throughout the food chain. This review addresses the use of lactic acid bacteria, which can inhibit fungal growth and participate in mycotoxin degradation and/or removal from contaminated food. Being beneficial for human and animal health, lactic acid bacteria have established themselves as an excellent solution to the problem of mycotoxin contamination, yet in practice their application in removing mycotoxins remains a challenge to be addressed by future research.
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Nakagawa, Hiroyuki. „Research on mycotoxin glucosides (masked mycotoxins)“. JSM Mycotoxins 66, Nr. 1 (2016): 21–25. http://dx.doi.org/10.2520/myco.66.21.
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Niermans, K., A. M. Meyer, E. F. Hoek-van den Hil, J. J. A. van Loon und H. J. van der Fels-Klerx. „A systematic literature review on the effects of mycotoxin exposure on insects and on mycotoxin accumulation and biotransformation“. Mycotoxin Research 37, Nr. 4 (07.10.2021): 279–95. http://dx.doi.org/10.1007/s12550-021-00441-z.
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AbstractNovel protein sources for animal feed are needed, and the use of insects as feed ingredient is explored. The insect production sector offers opportunities for a circular and sustainable approach to feed production by upgrading waste or side streams into high-quality proteins. However, potential food or feed safety issues should be studied in advance. Mycotoxins, such as aflatoxin B1, are natural contaminants commonly found in agricultural crops and have proven to be detrimental to the agricultural industry, livestock, and human health. This systematic review aims to provide a comprehensive overview of the published evidence on effects of mycotoxin exposure on insect growth and survival, mycotoxin accumulation within the insect body, and metabolization of various mycotoxins by insects. The review includes 54 scientific articles published in the past 55 years, in total covering 32 insect species. The main findings are the following: (1) Insects of the order Coleoptera show lower mortality after exposure to aflatoxin B1 when compared to Lepidoptera and Diptera; (2) effects of mycotoxins on larval growth and survival are less detrimental in later larval stages; (3) accumulation of mycotoxins was low in most insect species; (4) mycotoxins are metabolized within the insect body, the degree of which depends on the particular mycotoxin and insect species; (5) cytochrome P450s are the main family of enzymes involved in biotransformation of mycotoxins in some insect species. Results of this review support an optimistic outlook for the use of mycotoxin-contaminated waste streams as substrate for insect rearing.
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Claeys, Liesel, Sarah De Saeger, Ghislaine Scelo, Carine Biessy, Corinne Casagrande, Genevieve Nicolas, Michael Korenjak et al. „Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort“. Nutrients 14, Nr. 17 (30.08.2022): 3581. http://dx.doi.org/10.3390/nu14173581.
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Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox’s proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day. Results: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. Conclusions: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty.
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De Boevre, M., S. Landschoot, K. Audenaert, P. Maene, Diana Di Mavungu, M. Eeckhout, G. Haesaert und S. De Saeger. „Occurrence and within field variability of Fusarium mycotoxins and their masked forms in maize crops in Belgium“. World Mycotoxin Journal 7, Nr. 1 (01.01.2014): 91–102. http://dx.doi.org/10.3920/wmj2013.1608.
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Maize ear rot caused by several Fusarium species is an important fungal disease. Apart from yield losses, ear rot fungi can produce mycotoxins and masked forms in infected grains. Masked mycotoxins have received increased attention in view of their bioavailability and potential toxicity in animals and humans, but their presence and relevance in the field still remain undisclosed. To get a better insight, the present study assessed the presence of various Fusarium parent and masked mycotoxins, i.e. deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deoxynivalenol-3-glucoside, zearalenone, α-zearalenol, β-zearalenol, zearalenone-14-glucoside, zearalenone-14-sulfate, α-zearalenol-14-glucoside, β-zearalenol-14-glucoside, T-2 and HT-2 toxin, in various commercial maize varieties grown under natural infection conditions in Flanders, Belgium. The results showed that the maize varieties were co-contaminated with both parent and masked mycotoxins. Moreover, a positive correlation between these forms was established. A higher contamination with a particular mycotoxin appeared to be coupled with an elevated load of another (masked) mycotoxin. The results highlight the importance to screen for multiple mycotoxins, both parent and masked, to guarantee food and feed safety. Furthermore, analysis was carried out to elucidate the distribution of the various mycotoxins in the field. The maize variety did not significantly influence mycotoxin accumulation, except for deoxynivalenol. Subdivisions in the field with higher mycotoxin levels for deoxynivalenol and its derivatives, zearalenone and its derivatives, and the sum of T-2 and HT-2 toxin were observed.
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Ndemera, M., S. Landschoot, M. De Boevre, L. K. Nyanga und S. De Saeger. „Effect of agronomic practices and weather conditions on mycotoxins in maize: a case study of subsistence farming households in Zimbabwe“. World Mycotoxin Journal 11, Nr. 3 (18.09.2018): 421–36. http://dx.doi.org/10.3920/wmj2017.2227.
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Maize is susceptible to many mycotoxigenic fungi and mycotoxins, being prone to Fusarium spp. infection and subsequent mycotoxin contamination. Fumonisin B1 (FB1) is the predominant mycotoxin in Zimbabwean subsistence-grown maize and results of mycotoxin analyses indicated FB1 to be significantly higher compared to other mycotoxins. To fully elucidate maize agronomic practices influencing FB1 contamination of maize produced by Zimbabwean subsistence farming populations, an investigative field survey was conducted in the selected provinces of Mashonaland West and Manicaland. Agronomic data and associated climatic data were collected during the 2014/2015 agricultural season. A total of 158 maize samples were collected from households’ harvest, three months and six months post-harvest. Analysis and quantification of mycotoxin contamination in the maize samples was performed using a validated multi-mycotoxin analysis method with a scope of 23 mycotoxins. Maize was mainly contaminated by FB1. There was low mycotoxin co-occurrence in Zimbabwean maize, which was typically of Fusarium toxins. FB1 occurred in 23, 47 and 47% of samples at harvest, three and six months post-harvest, respectively. The corresponding means of positive samples were 609, 597 and 289 μg/kg, respectively. Regarding fumonisins, the choice of seed and fertiliser application were significant in modulating FB1 contamination. There was no significant difference in mean FB1 contamination during post-harvest maize storage. Daily temperatures were key factors influencing FB1 incidence and levels. High temperatures were associated with high FB1 contamination particularly at the flowering stage of maize. Rainfall was positively correlated with FB1 contamination. Good agricultural practices attributed to low FB1 contamination in maize pre-harvest. Post-harvest practices such as preserving seed integrity by preventing pest infestation using grain protection chemicals are important in achieving lower mycotoxin contamination and in particular, FB1, in maize grain.