Thematische Bibliographien / Multidrug nanoparticles

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Auswahl der wissenschaftlichen Literatur zum Thema „Multidrug nanoparticles“

Autor: Grafiati

Veröffentlicht am 29. März 2025

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Zeitschriftenartikel zum Thema "Multidrug nanoparticles"

& MAHMOOD, HAMID. „THE SYNERGISTIC EFFECT OF GOLD NANOPARTICLE LOADED WITH CEFTAZIDIUM ANTIBIOTIC AGAINST MULTIDRUG ERSISTANCE PSEUDOMONAS AERUGINOSA“. IRAQI JOURNAL OF AGRICULTURAL SCIENCES 52, Nr. 4 (22.08.2021): 828–35. http://dx.doi.org/10.36103/ijas.v52i4.1391.

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This study was aimed to evaluate the antimicrobial activity of gold nanoparticles that was synthesized by biological method using Aloe Vera extract. The Surface morphology of the synthesized gold nanoparticles was confirmed by Atomic force microscope (AFM) while the nature of functional groups present in gold nanoparticles was determined by FT-IR analysis. The antibacterial activity of gold nanoparticle was tested against multidrug resistance (MDR)pseudomonas aeruginosa, the results showed a significant effect against MDR isolates. Gold nanoparticle was loaded with ceftazidium antibiotic in order to improve the antibacterial activity and drug delivery efficiency. The synergistic effects of biosynthesize gold loaded with ceftazidium antibiotic at different concentration against MDR bacteria were also investigated. The result showed that ceftazidium-loaded nanoparticles have superior effectiveness compared to native ceftazidium against pseudomonas aeruginosa.

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Huq, Md Amdadul, Md Ashrafudoulla, Md Anowar Khasru Parvez, Sri Renukadevi Balusamy, Md Mizanur Rahman, Ji Hyung Kim und Shahina Akter. „Chitosan-Coated Polymeric Silver and Gold Nanoparticles: Biosynthesis, Characterization and Potential Antibacterial Applications: A Review“. Polymers 14, Nr. 23 (04.12.2022): 5302. http://dx.doi.org/10.3390/polym14235302.

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Biosynthesized metal nanoparticles, especially silver and gold nanoparticles, and their conjugates with biopolymers have immense potential in various fields of science due to their enormous applications, including biomedical applications. Polymeric nanoparticles are particles of small sizes from 1 nm to 1000 nm. Among different polymeric nanoparticles, chitosan-coated silver and gold nanoparticles have gained significant interest from researchers due to their various biomedical applications, such as anti-cancer, antibacterial, antiviral, antifungal, anti-inflammatory technologies, as well as targeted drug delivery, etc. Multidrug-resistant pathogenic bacteria have become a serious threat to public health day by day. Novel, effective, and safe antibacterial agents are required to control these multidrug-resistant pathogenic microorganisms. Chitosan-coated silver and gold nanoparticles could be effective and safe agents for controlling these pathogens. It is proven that both chitosan and silver or gold nanoparticles have strong antibacterial activity. By the conjugation of biopolymer chitosan with silver or gold nanoparticles, the stability and antibacterial efficacy against multidrug-resistant pathogenic bacteria will be increased significantly, as well as their toxicity in humans being decreased. In recent years, chitosan-coated silver and gold nanoparticles have been increasingly investigated due to their potential applications in nanomedicine. This review discusses the biologically facile, rapid, and ecofriendly synthesis of chitosan-coated silver and gold nanoparticles; their characterization; and potential antibacterial applications against multidrug-resistant pathogenic bacteria.

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Shair Mohammad, Imran, Birendra Chaurasiya, Xuan Yang, Chuchu Lin, Hehui Rong und Wei He. „Homotype-Targeted Biogenic Nanoparticles to Kill Multidrug-Resistant Cancer Cells“. Pharmaceutics 12, Nr. 10 (09.10.2020): 950. http://dx.doi.org/10.3390/pharmaceutics12100950.

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“Off-targeting” and receptor density expressed at the target sites always compromise the efficacy of the nanoparticle-based drug delivery systems. In this study, we isolated different cell membranes and constructed cell membrane-cloaked biogenic nanoparticles for co-delivery of antitumor paclitaxel (PTX) and multidrug resistance (MDR)-modulator disulfiram (DSF). Consequently, MDR cancer cell membrane (A549/T)-coated hybrid nanoparticles (A549/T CM-HNPs) selectively recognized the source cells and increased the uptake by ninefold via the homotypic binding mechanism. Moreover, the A549/T CM-HNPs sensitized MDR cells to PTX by suppressing P-glycoprotein (P-gp) activity by 3.2-fold and induced effective apoptosis (70%) in homologous A549/T cells. Cell-membrane coating based on the “homotypic binding” is promising in terms of promoting the accumulation of chemotherapeutics in MDR cells and killing them.

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Abd. Alaameri, Sally K., Huda S. A. Al-Hayanni und Labeeb A. K. Al-Zubaidi. „Antibacterial and anti-biofilm properties of biosynthesized Silver nanoparticles using Sumac (Rhus coriaria L.) extracts against some pathogenic bacteria“. Sumer 3 8, CSS 3 (15.10.2023): 1–15. http://dx.doi.org/10.21931/rb/css/2023.08.03.53.

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Multidrug-resistant bacteria have contributed to a rise in morbidity and death from microbial infections, making it more difficult to treat illnesses caused by resistant pathogenic bacteria. There is a growing interest in using nanoparticles as biomaterials around the globe. Nanoparticles might become a crucial, feasible therapeutic alternative for treating infections resistant to several drugs. Currently, they are recognized as feasible alternatives or additions to conventional antimicrobials. Nanotechnology focuses on developing eco-friendly methods for producing nanoparticles. The current work aims to generate a quick, ecologically friendly approach for synthesizing silver nanoparticles utilizing aqueous and alcohol sumac plant extracts. These silver nanoparticles appear synthesized and capped by sumac extract bioactive components. FTIR, XRD, SEM, AAS, EDX, AFM, and UV-Vis spectroscopy were used to determine the nanoparticle structure, shape, and optical properties. Within 15 minutes, the AgNPs had formed. The aqueous and alcoholic sumac extracts resulted in silver nanoparticles with an average particle size of 43.82 nm and 39.55 nm, respectively. Against the multi-drug-resistant clinical isolates, silver nanoparticles from both extracts had good antibacterial activity (Staphylococcus aureus, Acinetobacter baumannii, Enterococcus faecalis, and Pseudomonas aeruginosa). Also, these nanoparticles had an inhibitory effect on the productivity of the biofilm virulence factor. For this study with highly significant differences (P≤0.01). Keywords: Silver nanoparticles, Green synthesis, Rhus coriaria L., Sumac, antibacterial activity, antibiofilm activity; multidrug-resistant bacteria.

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Roszczenko, Piotr, Olga Klaudia Szewczyk, Robert Czarnomysy, Krzysztof Bielawski und Anna Bielawska. „Biosynthesized Gold, Silver, Palladium, Platinum, Copper, and Other Transition Metal Nanoparticles“. Pharmaceutics 14, Nr. 11 (25.10.2022): 2286. http://dx.doi.org/10.3390/pharmaceutics14112286.

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Nanomedicine is a potential provider of novel therapeutic and diagnostic routes of treatment. Considering the development of multidrug resistance in pathogenic bacteria and the commonness of cancer, novel approaches are being sought for the safe and efficient synthesis of new nanoparticles, which have multifaceted applications in medicine. Unfortunately, the chemical synthesis of nanoparticles raises justified environmental concerns. A significant problem in their widespread use is also the toxicity of compounds that maintain nanoparticle stability, which significantly limits their clinical use. An opportunity for their more extensive application is the utilization of plants, fungi, and bacteria for nanoparticle biosynthesis. Extracts from natural sources can reduce metal ions in nanoparticles and stabilize them with non-toxic extract components.

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Shrivastava, A., RK Singh, PK Tyagi und D. Gore. „Synthesis of Zinc Oxide, Titanium Dioxide and Magnesium Dioxide Nanoparticles and Their Prospective in Pharmaceutical and Biotechnological Applications“. Journal of Biomedical Research & Environmental Sciences 2, Nr. 1 (11.01.2021): 011–20. http://dx.doi.org/10.37871/jbres1180.

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The use of nanoparticles for the therapeutic purpose is gaining pronounced importance. In the last two decades, a number of nanomedicines received regulatory approval and several showed promises through clinical trials. In this content, it is important to synthesize nanoparticles from various sources and to check its efficiency, especially its antibacterial activity. In today’s scenario number nanomedicines are proving useful to control multidrug resistance and since the mechanism of action of nanoparticles is totally different from the small molecules like antibiotics it obviates the chances of drug resistance. In this review, we discussed three metal-based nanoparticles prepared from various reducing sources namely Zinc Oxide Nanoparticle (ZnO NPs), Titanium Dioxide Nanoparticle (TiO2 NPs) and Magnesium Dioxide Nanoparticle (MnO2 NPs). The focus also made towards the safety assessment of the several nanoparticles. In addition, the exact interaction of the nanoparticles with the bacterial cell surface and the resultant changes also been highlighted. The review put forward the sources, method, and antibacterial success of these nanoparticles so that future nanomedicines could be put forward.

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Zaineb, Tayyaba, Bushra Uzair, Waleed Y. Rizg, Waleed S. Alharbi, Hala M. Alkhalidi, Khaled M. Hosny, Barkat Ali Khan, Asma Bano, Mohammed Alissa und Nazia Jamil. „Synthesis and Characterization of Calcium Alginate-Based Microspheres Entrapped with TiO2 Nanoparticles and Cinnamon Essential Oil Targeting Clinical Staphylococcus aureus“. Pharmaceutics 14, Nr. 12 (09.12.2022): 2764. http://dx.doi.org/10.3390/pharmaceutics14122764.

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It is important to create new generations of materials that can destroy multidrug-resistant bacterial strains, which are a serious public health concern. This study focused on the biosynthesis of an essential oil entrapped in titanium dioxide (TiO2) calcium alginate-based microspheres. In this research, calcium alginate-based microspheres with entrapped TiO2 nanoparticles and cinnamon essential oil (CI-TiO2-MSs) were synthesized, using an aqueous extract of Nigella sativa seeds for TiO2 nanoparticle preparation, and the ionotropic gelation method for microsphere preparation. The microspheres obtained were spherical, uniformly sized, microporous, and rough surfaced, and they were fully loaded with cinnamon essential oil and TiO2 nanoparticles. The synthesized microspheres were analyzed for antibacterial activity against the clinical multidrug-resistant strain of Staphylococcus aureus. Disc diffusion and flow cytometry analysis revealed strong antibacterial activity by CI-TiO2-MSs. The synthesized CI-TiO2-MSs were characterized by the SEM/EDX, X-ray diffraction, and FTIR techniques. Results showed that the TiO2 nanoparticles were spherical and 99 to 150 nm in size, whereas the CI-TiO2-MSs were spherical and rough surfaced. Apoptosis analysis and SEM micrography revealed that the CI-TiO2-MSs had strong bactericidal activity against S. aureus. The in vitro antibacterial experiments proved that the encapsulated CI-TiO2-MSs had strong potential for use as a prolonged controlled release system against multidrug-resistant clinical S. aureus.

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Abdelhamid, Mohamed A. A., Mi-Ran Ki, Amer Ali Abd Abd El-Hafeez, Ryeo Gang Son und Seung Pil Pack. „Tailored Functionalized Protein Nanocarriers for Cancer Therapy: Recent Developments and Prospects“. Pharmaceutics 15, Nr. 1 (03.01.2023): 168. http://dx.doi.org/10.3390/pharmaceutics15010168.

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Recently, the potential use of nanoparticles for the targeted delivery of therapeutic and diagnostic agents has garnered increased interest. Several nanoparticle drug delivery systems have been developed for cancer treatment. Typically, protein-based nanocarriers offer several advantages, including biodegradability and biocompatibility. Using genetic engineering or chemical conjugation approaches, well-known naturally occurring protein nanoparticles can be further prepared, engineered, and functionalized in their self-assembly to meet the demands of clinical production efficiency. Accordingly, promising protein nanoparticles have been developed with outstanding tumor-targeting capabilities, ultimately overcoming multidrug resistance issues, in vivo delivery barriers, and mimicking the tumor microenvironment. Bioinspired by natural nanoparticles, advanced computational techniques have been harnessed for the programmable design of highly homogenous protein nanoparticles, which could open new routes for the rational design of vaccines and drug formulations. The current review aims to present several significant advancements made in protein nanoparticle technology, and their use in cancer therapy. Additionally, tailored construction methods and therapeutic applications of engineered protein-based nanoparticles are discussed.

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Ahmed, Faraidun A., Khadijakhalil M. Barzani und Payman A. Hamasaeed. „Antibacterial and Wound Healing Assessment of Silver Nanoparticles against Multidrug-Resistant Klebsiella variicola“. Cihan University-Erbil Scientific Journal 8, Nr. 2 (20.08.2024): 49–55. http://dx.doi.org/10.24086/cuesj.v8n2y2024.pp49-55.

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The increase in antimicrobial resistance and the absence of novel antibiotic development cause problems in controlling infections for wound healing. Antibacterial properties of nanomaterials have emerged as a potentially effective approach in the pursuit of superior alternatives, nevertheless, the toxicity associated with higher concentrations has emerged as a significant obstacle. According to this study, green nanoparticle synthesis is demonstrated to be both economical and biocompatible on account of the bioactive compounds present. In the present work, silver nanoparticles prepared by using Pistacia khinjuk gum, then, nanoparticle-based cream was prepared and compared with Fusidin and Vaseline creams via assessment in vitro antibacterial and in vivo wound healing activity on Wistar albino rats infected with multi drug resistant Gram negative bacteria which was newly recorded in Iraq, namely Klebsiella variicola. The findings revealed that the application of nanoparticle cream resulted in more rapid and effective wound healing (11 days), demonstrating a significant synergistic effect in comparison to Fusidin (16 days), Vaseline (20 days), and the untreated control group rats (32 days). The results indicated that green nanoparticles proved to be a significant strategy in the fight against multidrug resistant bacteria, without any toxicity concerns.

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Chidambaram, Moorthi, R. Manavalan und K. Kathiresan. „Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations“. Journal of Pharmacy & Pharmaceutical Sciences 14, Nr. 1 (16.02.2011): 67. http://dx.doi.org/10.18433/j30c7d.

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Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy.

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Dissertationen zum Thema "Multidrug nanoparticles"

Trần, Natalie Lan Linh. „Innovative multidrug nanomedicines for the treatment of myocardial ischemia/ reperfusion injuries“. Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ073.

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L'ischémie/ reperfusion cardiaque est une condition pathologique complexe impliquant divers mécanismes de signalisation. En raison de leurs interactions, les traitements disponibles pour les lésions de reperfusion sont souvent insuffisants. Il est donc crucial d'explorer des approches intégrantes plusieurs agents ciblant différentes voies biologiques. Bien que la nanomédecine offre des opportunités pour protéger les principes actifs et optimiser le ciblage thérapeutique, elle fait face à des défis tels qu'un faible taux d'incorporation des médicaments. La méthode de squalenoylisation pourrait résoudre ces problèmes. Nous avons d'abord étudié in vitro les nanoparticules à base de squalène contenant de la cyclosporine A (SqCsA), en évaluant leur toxicité et capacité cardioprotective. Nous avons ensuite testé des formulations de squalène-adénosine (SQAd) dans un modèle murin in vivo, observant des effets bénéfiques sur la fonction cardiaque, bien que sans atteindre une signification statistique. Par la suite, nous avons développé des nanoparticules SQAd/Vit E, testées dans un modèle rat amélioré d'ischémiereperfusion myocardique, et utilisé des méthodes d'analyse approfondies pour capturer des effets cardioprotecteurs détaillés. Enfin, nous avons étudié la formation de la couronne protéique sur ces nanoparticules afin d'éclairer leur comportement in vivo dans les fluides biologiques. Ces travaux soulignent le potentiel des nouvelles formulations nanomédicales dans le traitement des lésions d'I/R cardiaques
Myocardial ischemia/ reperfusion is a complex pathological condition involving various signaling mechanisms. Due to their interactions, available treatments for reperfusion injuries often prove insufficient. It is crucial to explore approaches that integrate multiple agents targeting different biological pathways. While nanomedicine offers opportunities to protect active ingredients and optimize therapeutic targeting, it faces challenges like low drug incorporation rates. The squalenoylation method holds potential to address these issues. We first studied squalene-based NPs containing cyclosporine A (SqCsA) in vitro, assessing their toxicity and cardioprotective capacity. We then tested squalene-adenosine formulations (SQAd) in an in vivo mouse model, observing beneficial effects on cardiac function, though statistical significance was not reached. Subsequently, we developed SQAd/Vit E nanoparticles and tested them in an optimized rat model of myocardial ischemia-reperfusion, applying comprehensive analysis methods and captured detailed cardioprotective effects. Finally, we investigated protein corona formation on these nanoparticles to shed light on their in vivo behavior in biological fluids. These findings highlight the potential of novel nanomedical formulations in treating cardiac I/R injuries

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Vlerken, Lilian Emilia van. „Modulation of multidrug resistance in cancer using polymer-blend nanoparticles : thesis /“. Diss., View dissertation online, 2008. http://hdl.handle.net/2047/d10017355.

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Taute, C. J. F. „Tumour specific targeted in vitro theranostics application of fabricated nanostructures in a multi-drug resistant ovarian carcinoma cell line“. Thesis, University of the Western Cape, 2013. http://hdl.handle.net/11394/4530.

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Philosophiae Doctor - PhD
Ovarian cancer is called the “Silent Killer” as it is often diagnosed in advanced stages of the disease or misdiagnosed which ends with a poor prognostic outcome for the patient. A high rate of disease relapse, a high incidence-to-mortality ratio as well as acquired multidrug resistance makes it necessary to find alternative diagnostic- and therapeutic tools for ovarian cancer. Nanotechnology describes molecular devices with at least one dimension in the sub- 1μm scale and has been suggested as a possible solution for overcoming challenges in cancer multidrug resistance as well as early diagnosis of the disease. One-pot synthesized gold nanoparticles were used to demonstrate in vitro drug delivery of doxorubicin in a manner which overcame the cytoprotective mechanisms of a multidrug resistant ovarian carcinoma cell line (A2780cis) by inducing apoptosis mediated by caspase-3 within 3h of treatment. The gold nanoparticles were further functionalized with nitrilotriacetic acid and displayed specific interaction with a 6xHis-tagged cancer targeting peptide, chlorotoxin. Proprietary indium based quantum dots were functionalized with the same surface chemistry used for gold nanoparticles and bioconjugated with chlorotoxin. Wide field fluorescence studies showed the peptide-quantum dot construct specifically targeted enhanced green fluorescent tagged matrix metalloproteinase-2 transfected A2780cis cells in a specific manner. The cytoprotective multidrug resistant mechanisms of the ovarian carcinoma was overcome successfully with a single dose of doxorubicin loaded gold nanoparticles and tumour specific targeting was demonstrated using quantum dots with a similar surface chemistry used for the gold nanoparticles.

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Sen, Gulseren Petek. „Fabrication Of Poly (dl-lactic-co-glycolic Acid) Nanoparticles And Synthetic Peptide Drug Conjugate For Anti-cancer Drug Delivery“. Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12611405/index.pdf.

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Cancer is a group of diseases in which normal cells are converted to cells capable of autonomous growth and invasion. In the chemotherapeutic control of cancer, drugs are usually given systemically so they reach toxic levels in healthy cells as well as cancer cells. This causes serious side effects. Another important problem with chemotherapy is resistance developed to cytotoxic drugs (multi drug resistance). Doxorubicin (Dox) occupies a central position in the treatment of breast cancer. However doxorubicin induced cardiac toxicity is associated with a high incidence of morbidity and mortality. Resistance of malignant tumors to Dox is another important cause of treatment failure in patients with cancer. One approach to overcome Dox-related toxicity is to use polymeric drug carriers, which direct the Dox away from heart tissue, and allow usage of lower dosages. In this present study two different anti-cancer drug delivery methods were evaluated. Dox was encapsulated in PLGA microparticles by single and double microemulsion solvent evaporation techniques. The highest entrapment of doxorubicin within PLGA microspheres obtained by optimization of process parameters. A sustained release of doxorubicin was obtained for 20 days. Several protein transduction domains are known to have the ability to pass through biological membranes. One such peptide is HIV-1 TAT. In this study TAT was evaluated for its ability to carry Dox into Dox resistant MCF-7 tumor cells. Dox peptide conjugate was more potent than free drug. The concentration of drug in resistant cancer cells was increased indicating a partial reversal of drug resistance.

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Wan, Chung Ping Leon. „The effect of P-glycoprotein inhibition and ultrasound exposure on the cytotoxicity of taxane loaded diblock copolymer nanoparticles in multidrug resistant cells“. Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/49957.

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One of the major mechanisms of multidrug resistance involves an efflux protein, P-glycoprotein (Pgp), which pumps commonly used anticancer drugs such as taxanes out of cells, leading to a decrease in cellular drug accumulation. The overall goal of this project was to develop strategies to enhance intracellular drug accumulation and cytotoxicity of nanoparticulate taxanes in multi-drug resistant (MDR) cell lines. Paclitaxel (PTX) loaded nanoparticles fabricated from micelle forming MePEG₁₁₄-b-PCL₁₉ and nanosphere forming MePEG₁₁₄-b-PCL₁₀₄ were compared for drug and block copolymer uptake, and cytotoxicity in drug sensitive MDCKII and drug resistant MDCKII-MDR1 cell lines. PTX loaded micelles were more cytotoxic than PTX loaded nanospheres. Co-administration of the known Pgp inhibitor, MePEG₁₇-b-PCL₅, with PTX loaded micelles or nanospheres significantly increased drug cytotoxicity in MDCKII-MDR1 cells. Mixed molecular weight (MW) PCL₂₀₀/PCL₅ nanoparticles composed of long hydrophobic block, MePEG₁₁₄-b-PCL₂₀₀, and MePEG₁₇-b-PCL₅, were developed and characterized for the co-delivery of taxanes and Pgp inhibitor. Both PTX and docetaxel (DTX) loaded mixed MW PCL₂₀₀/PCL₅ nanoparticles were demonstrated to release MePEG₁₇-b-PCL₅ in a controlled release manner and increase drug cytotoxicity in MDR cells as compared to the drug loaded MePEG₁₁₄-b-PCL₂₀₀ nanoparticles in the absence of MePEG₁₇-b-PCL₅. The mixed MW nanoparticles remained in the plasma for longer than the drugs with approximately 3% of the injected dose remaining 24 hrs post injection. Ultrasound irradiation was investigated as a potential strategy to enhance the cytotoxicity of PTX loaded MePEG-b-PDLLA micelles in MDR cells. Using an ultrasound regime of a single 10-second burst of high frequency (4 MHz) and high intensity (32 W/cm²) ultrasound, it was shown that ultrasound irradiation resulted in a two-fold increase in intracellular uptake of PTX in drug sensitive MDCKII and MCF-7 cell lines and their respective Pgp-overexpressing MDCKII-MDR1 and NCI-ADR counterparts as compared to untreated cells (no ultrasound). The enhanced accumulation and retention of PTX resulting from ultrasound treatment translated into greater cytotoxicity in both drug sensitive and resistant cell lines. In conclusion, we have demonstrated two promising strategies for enhancing MDR cellular drug accumulation and effectiveness: the use of mixed molecular weight taxane loaded nanoparticles and ultrasound irradiation.
Pharmaceutical Sciences, Faculty of
Graduate

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Ngema, Xolani Terrance. „Metallic nanoparticles with polymeric shell: A multifunctional platform for application to biosensor“. University of the Western Cape, 2018. http://hdl.handle.net/11394/6330.

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Philosophiae Doctor - PhD (Chemistry)
Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (MTB) that usually affects the lungs leading to severe coughing, fever and chest pains. It was estimated that over 9.6 million people worldwide developed TB and 1.5 million died from the infectious disease of which 12 % were co-infected with human immunodeficiency virus (HIV) in the year 2015. In 2016 the statistics increased to a total of 1.7 million people reportedly died from TB with an estimated 10.4 million new cases of TB diagnosed worldwide. The development of the efficient point-of-care systems that are ultra-sensitive, cheap and readily available is essential in order to address and control the spread of the tuberculosis (TB) disease and multidrugresistant tuberculosis.

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Dormont, Flavio. „Development of nanomedicines for inflammation disorders : evaluation of pharmacological efficacy on preclinical models Nanomedicines for the management of Sepsis Nanoplumbers: Biomaterials to fight cardiovascular diseases Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation Translation of Nanomedicines from Lab to Industrial Scale Synthesis: The Case of Squalene-Adenosine Nanoparticles“. Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS451.

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Les syndromes inflammatoires, marqués par une réaction excessive du système immunitaire, sont associés à de nombreuses conditions pathologiques comme le sepsis, les accidents d’ischémie/reperfusion ou l’athérosclérose. En effet, une réponse inflammatoire excessive à l’encontre des tissus caractérise souvent l’apparition et la pathophysiologie de ces maladies complexes pour lesquelles ils manquent toujours des traitements efficaces. Ainsi, la plupart des thérapies disponibles pour adapter la réponse inflammatoire sont limitées la plupart du temps par des effets secondaires indésirables, une mauvaise spécificité et par l’apparition d’états d’immunodéficience.Des avancées en délivrance de médicaments ont permis le développement de nombreux outils qui aident à adapter la stratégie d’administration d’agents pharmaceutiques. Notamment, les “nanomédecines” ont permis d’obtenir de nombreuses innovations en oncologie et en technologie diagnostique. En améliorant le ciblage des médicaments et en protégeant l’agent pharmaceutique d’une métabolisation précoce, les nanomedicines permettent d’améliorer l’index thérapeutique de certaines molécules, résultant en une amélioration du prognostic patient. Néanmoins, avec ces promesses viennent des limitations notables, comme le faible taux de chargement en drogue de certaines nanoformulations, un développement industriel compliqué ou un mauvais contrôle du relargage.Pour répondre à ces limitations, l’équipe du Pr. Couvreur développe depuis 2004 une nouvelle stratégie d’encapsulation des médicaments, appelée « squalenoylisation ». Ainsi, le couplage d’agents actifs avec des dérivés du squalène, un lipide endogène, biocompatible et biodégradable, permet d’obtenir des nanoparticules stables, avec haut taux de chargement et faible toxicité. Les nanoparticules obtenues présentent dans de nombreux cas une pharmacocinétique plus avantageuses ainsi que distribution plus ciblée aux zones pathologique. L’application de cette technique à l’adénosine, une molécule au potentiel thérapeutique important mais limité par un temps de demi-vie plasmatique extrêmement court, a fourni des résultats particulièrement prometteurs dans le cadre du traitement de l’ischémie cérébrale et du traumatisme de la moëlle épinière.Un autre avantage des nanoparticules à base de squalène est qu’elles rendent possible l’encapsulation de plusieurs agents thérapeutiques au sein d’un même système, permettant ainsi des traitements multi-drogue. Ceci est un outil important dans le contexte d’une réponse excessive du système immunitaire, où convergent souvent plusieurs facteurs pour faire progresser la maladie. Par exemple, il a été établi que l’auto-inflammation est souvent maintenue par des cercles vicieux entre stress oxydant et cascades pro-inflammatoires, ces deux voies de signalisation contribuant l’une à l’autre et inhibant le retour à l’homéostasie. Il n’existe pour l’instant pas de thérapies efficaces contre ce couplage pathologique. Part conséquent, un des objectifs de cette thèse était de développer et de tester sur de modèles précliniques d’inflammation excessive, des nanoparticules à base de squalène encapsulant deux agents thérapeutiques : l’adénosine, comme médiateur endogène des réponses inflammatoires et un antioxydant comme inhibiteur du stress oxydant. Notre hypothèse étant qu’une thérapie multi-drogue pourrait être avantageuse pour contrer les nombreux processus pathogènes qui se renforcent mutuellement lors des réponses inflammatoires ; mais aussi qu’une formulation sous forme de nanoparticules pourrait fournir des propriétés de ciblage intéressantes
Advances in drug delivery have led to the development of many tools that help tailor the drug delivery strategy. In particular, “nanomedicines” have made it possible to obtain numerous innovations in oncology and diagnostic technology. By improving drug targeting and protecting the pharmaceutical agent from early metabolism, nanomedicines improve the therapeutic index of certain molecules, resulting in improved patient prognosis. However, with these promises come notable limitations, such as the low drug loading rate of certain nanoformulations, complicated industrial development or poor release control. Squalene-based nanoparticles have been developed to meet these limitations. Another advantage of squalene-based nanoparticles is that they make it possible to encapsulate several therapeutic agents within the same system, thus allowing multi-drug treatments.This is an important tool in the context of an excessive inflammatory response, where many factors often converge to advance the disease. Therefore, one of the objectives of this thesis was to develop and test on preclinical models of inflammation, squalene-based nanoparticles encapsulating two therapeutic agents: adenosine, as an endogenous mediator of inflammatory responses and an antioxidant as an inhibitor of oxidative stress. Our hypothesis is that a multi-drug therapy could be advantageous to counter the many pathogenic processes which reinforce each other during inflammatory responses, but also that a formulation in the form of nanoparticles could provide interesting targeting properties. During the work of this thesis, we also have the feasibility of industrial translation of the synthesis of squalene-based bioconjugates

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Carrasco, Letícia Dias de Melo. „Arrranjos supramoleculares de lípide catiônico, antibióticos e polímeros: preparação, caracterização e atividade contra bactérias multirresistentes e micobactérias de crescimento rápido“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04082016-092804/.

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Arranjos supramoleculares combinando o lípide catiônico brometo de dioctadecildimetilamônio (DOD) com polímeros, como carboximetilcelulose (CMC) e cloreto de poli(dialildimetilamônio) (PDDA), foram preparados na forma de nanopartículas (NPs), na ausência ou presença de antimicrobiano tradicional, como a claritromicina (CLA). NPs preparadas por atração eletrostática entre os fragmentos de bicamada (BF) de DOD, CMC e PDDA foram avaliadas, in vitro, quanto à atividade contra isolados clínicos de micro-organismos multirresistentes (MR) a antimicrobianos, como Pseudomonas aeruginosa MR, Klebsiella pneumoniae produtora da enzima carbapenemase do tipo KPC, Staphylococcus aureus resistente à meticilina/oxacilina (MRSA) e Candida albicans resistente ao fluconazol, através do método de plaqueamento e contagem de viáveis. As NPs de DOD BF/CMC/PDDA apresentam alta atividade de amplo espectro contra micro-organismos MR, em que o PDDA é o componente responsável pela excelente atividade biocida das NPs. O mecanismo de ação antimicrobiana indica a dissociação dessas NPs na presença dos micro-organismos, com a remoção de biopolímeros da parede celular microbiana pelo PDDA, conforme visualizado por microscopia eletrônica de varredura, ocorrendo lise da membrana microbiana e liberação de compostos fosforilados para o meio extracelular. Também foram desenvolvidas neste trabalho NPs carreadoras de CLA à base de DOD e polímeros. Solução etanólica contendo CLA/DOD foi injetada em solução aquosa de CMC, formando arranjos coloidalmente estáveis e aniônicos, que posteriormente foram adicionados de solução de PDDA, para a obtenção de arranjos estáveis e catiônicos. CLA/DOD/CMC e CLA/DOD/CMC/PDDA NPs incorporaram CLA em quantidade suficiente para inibir o crescimento de M. abscessus no interior de macrófagos bem como evitar a formação de biofilmes, sendo que altas doses de CLA foram tóxicas aos macrófagos, enquanto doses menores apresentaram baixa toxicidade e boa atividade antimicrobiana. NPs catiônicas carreando CLA foram tóxicas aos macrófagos nas concentrações de PDDA testadas. A natureza particulada das CLA NPs possivelmente aumenta a retenção intracelular de CLA em comparação com CLA livre, podendo prolongar atividade da CLA contra patógenos intracelulares. Desta maneira, arranjos supramoleculares combinando lípide e polímeros, com ou sem antimicrobianos tradicionais poderão encontrar diversas aplicações nas áreas farmacêutica, médica, alimentícia e biotecnológica.
Supramolecular assemblies combining cationic lipid dioctadecyldimethylammonium bromide (DOD) and polymers, such as sodium carboxymethylcellulose (CMC) and poly(diallyldimethylammonium chloride) (PDDA), were prepared as nanoparticles (NPs), in the absence or presence of traditional antibiotic, such as clarithromycin (CLA). NPs prepared by electrostatic attraction between DOD bilayer fragments (BF), CMC and PDDA were evaluated against clinical strains of multidrug resistant (MDR) microorganisms, such as Pseudomonas aeruginosa MDR, Klebsiella pneumoniae producer of KPC carbapenemase enzyme, methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans fluconazole resistant, by plating and colony forming unities counting. DOD BF/CMC/PDDA NPs display high and broad-spectrum activity against MDR microrganisms, and PDDA is the excellent biocidal component in the NPs. The mechanism of antimicrobial action shows that NPs disassembly in the presence of microrganisms, with biopolymers withdrawn from the cell wall, as observed by scanning electron microscopy, consecutively lysing bacterial membrane as determined from the leakage of inner phosphorylated compounds. In this work there have also been developed NPs, based on lipid and polymers, as carriers for CLA. Ethanolic solution co-solubilizing CLA/DOD was injected in CMC aqueous solution, yielding colloidaly stable and anionic NPs, that were further added of PDDA solution, yielding stable and cationic NPs. CLA/DOD/CMC NPs and CLA/DOD/CMC/PDDA NPs incorporated CLA at doses high enough to inhibit M. abscessus growth inside macrophages or in biofilms. Larger CLA doses were toxic to macrophages while lower CLA doses reduced toxicity to macrophages despite their high antimicrobial activity. Cationic CLA NPs exhibited substantial toxicity against macrophages at the PDDA concentrations tested. The particulate nature of these CLA NPs possibly increases intracellular CLA retention in comparison to free CLA, probably extending CLA activity against intracellular pathogens. In conclusion, supramolecular assemblies combining cationic lipid and polymers, with or without traditional antibiotics, may find multiple possibilities of applications at pharmaceutical, medical, food and biotecnological fields.

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Dreaden, Erik Christopher. „Chemistry, photophysics, and biomedical applications of gold nanotechnologies“. Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/51320.

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Gold nanoparticles exhibit a combination of physical, chemical, optical, and electronic properties unique from all other nanotechnologies. These structures can provide a highly multifunctional platform with which to diagnose and treat diseases and can dramatically enhance a variety of photonic and electronic processes and devices. The work herein highlights some newly emerging applications of these phenomena as they relate to the targeted diagnosis and treatment of cancer, improved charge carrier generation in photovoltaic device materials, and strategies for enhanced spectrochemical analysis and detection. Chapter 1 introduces the reader to the design, synthesis, and molecular functionalization of gold nanotechnologies, and provides a framework from which to discuss the unique photophysical properties and applications of these nanoscale materials and their physiological interactions in Chapter 2. Chapter 3 discusses ongoing preclinical research in our lab investigating the use of near-infrared absorbing gold nanorods as photothermal contrast agents for laser ablation therapy of solid tumors. In Chapter 4, we present recent work developing a novel strategy for the targeted treatment of hormone-dependent breast and prostate tumors using multivalent gold nanoparticles that function as highly selective and potent endocrine receptor antagonist chemotherapeutics. In Chapter 5, we discuss a newly-emerging tumor-targeting strategy for nanoscale drug carriers which relies on their selective delivery to immune cells that exhibit high accumulation and infiltration into breast and brain tumors. Using this platform, we further investigate the interactions of nanoscale drug carriers and imaging agents to a transmembrane protein considered to be the single most prevalent and single most important contributor to drug resistance and the failure of chemotherapy. Chapter 6 presents work from a series of studies exploring enhanced charge carrier generation and relaxation in a hybrid electronic system exhibiting resonant interactions between photovoltaic device materials and plasmonic gold nanoparticles. Chapter 7 concludes by presenting studies investigating the contributions from so-called “dark” plasmon modes to the spectrochemical diagnostic method known as surface enhanced Raman scattering.

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Hsiao, Jui-Pin, und 蕭睿彬. „Development of nanoparticles with chemotherapeutic/siRNA dual functions against multidrug-resistant cancer cells“. Thesis, 2010. http://ndltd.ncl.edu.tw/handle/20319311035879470789.

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碩士
臺灣大學
醫學工程學研究所
98
To realize gene therapy and chemotherapy in multi-drug-resistant cancer cell, we develop carriers which can co-delivery gene and chemotherapy drug. The mPEG-PCL-PEI (M510i) tri-block polymers were synthesized by use mMPEG-PCL copolymer modified to PEI. The characteristic of these tri-block polymers were evaluated by 1H nuclear magnetic resonance and gel permeation chromatography. The critical micelle concentration (CMC) of micelle was evaluated by using pyrene as fluorescence probe. The particle size, zeta potential, and morphology of micelle was studied by dynamic light scattering and transmission electron microscopy. The results indicate that the paclitaxel loaded micelles and DNA complexes with micelles were 226 nm and 238 nm. The gene transfection efficiency was evaluated by used flow cytometry to evaluate green fluorescence protein (GFP) expression. The gene transfection efficiency performed better than PEI 25K in MCF-7 ADR cell. In siRNA experiments, we can transfect MDR-1 siRNA to silence P-glycoprotein expression 50%. In viro cytotoxicity, dual agent micelle of were tested of MCF-7 wt and MCF-7 ADR by MTT assy. These results suggested the PEG-PCL-PEI tri-block polymer as potential carriers for gene therapy and chemotherapy.

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Bücher zum Thema "Multidrug nanoparticles"

Banu, Afreen, Vandana Rathod und E. Ranganath. Synthesis and Characterization of Silver Nanoparticles by Rhizopus Stolonifer and Its Activity Against Multidrug Resistant Escherichia Coli and S. GRIN Verlag GmbH, 2012.

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Wong, Ho-Lun. A study of nanoparticle drug carrier for treatment of multidrug-resistant breast cancer with loco-regional involvement. 2006.

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Buchteile zum Thema "Multidrug nanoparticles"

Palaskar, Rutuja S., Darshana S. Dhokane und Balaprasad G. Ankamwar. „Green-Synthesized Nanoparticles to Combat Multidrug-Resistant Bacteria“. In Nanotechnology Based Strategies for Combating Antimicrobial Resistance, 511–32. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-2023-1_19.

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Chandrasekaran, Aiswarya, und G. H. R. Eranga Karunaratne. „Use of Nanoparticles in Multidrug Resistant Tuberculosis Diagnosis“. In Nanotechnology for Infectious Diseases, 371–86. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9190-4_17.

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Hossain, Md Monir, Shakil Ahmed Polash, Tanushree Saha und Satya Ranjan Sarker. „Gold Nanoparticles: A Lethal Nanoweapon Against Multidrug-Resistant Bacteria“. In Nanotechnology in the Life Sciences, 311–51. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-10220-2_9.

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Uddin, Imran, Divya S. Parimi, Tarun K. Bollu, Chandra S. Bhatt und Anil K. Suresh. „Silver Nanoparticles as Potent Multidrug-Resistant Incorporants in Biomedicine“. In Emerging Modalities in Mitigation of Antimicrobial Resistance, 475–88. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84126-3_21.

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Tian, Sichao, Peiyan Yuan und Qing-Hua Xu. „Metal Nanoparticles As Alternative Antimicrobial Agents to Combat Multidrug Resistance Bacteria“. In Nanotechnology Based Strategies for Combating Antimicrobial Resistance, 81–115. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-2023-1_4.

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Bharadwaj, Kaushik Kumar, Bijuli Rabha, Bhabesh Kumar Choudhury, Aditi Das, Lydia Islary, Dorothy Bhattacharjya, Monoswi Chakraborty, Debabrat Baishya und Arabinda Ghosh. „Role of Gold Nanoparticles Against Multidrug Resistance (MDR) Bacteria: An Emerging Therapeutic Revolution“. In Emerging Modalities in Mitigation of Antimicrobial Resistance, 489–511. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84126-3_22.

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Ahmed, Abeer Ahmed Qaed, Lin Xiao, Tracey Jill Morton McKay und Guang Yang. „Green Metal-Based Nanoparticles Synthesized Using Medicinal Plants and Plant Phytochemicals against Multidrug-Resistant Staphylococcus aureus“. In Green Synthesis in Nanomedicine and Human Health, 181–246. First edition. | Boca Raton, FL : CRC Press, [2021]: CRC Press, 2021. http://dx.doi.org/10.1201/9781003023197-15.

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Parmar, Ankush, und Shweta Sharma. „Nanoparticles: A Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections—A Holistic View on Underlying Mechanisms and Antibacterial Properties“. In Biomedical Translational Research, 153–77. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9232-1_11.

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Pinky, Nirantak Kumar und Ankita Sharma. „Synergic Effects of Nanoparticles with other Drugs and Their Combined Effects“. In Plant Mediated Synthesis of Metal Nanoparticles, 109–28. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815256352124010007.

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As discussed in previous chapters that the formation of nanoparticles results in various advantages for multidrug delivery when combined with particular drug as compared to free drugs. So this article emphasize on use of nanoparticle and drug combination to reduce the toxicity and improve the efficiency which is given in the form of advantages. Drud combination analysis has been explained in the form of isoboles and dose equivalent etc. Synergic effects of drug-nanoparticle combination on bacteria, fungi, virus, diabetes and cancer has been shown by proper mechanism. Beside these harmful effects of nanoparticles alone has been discussed in this section. Drugs are combined with various metal nanoparticles such as gold, silver, copper etc. has been shown to act as excellent agents to cure diseases effectively.

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Bisht, Shiwali, und Lovely Tyagi. „ADVANCES IN NANOTECHNOLOGY FOR CREATING ANTIBACTERIAL DRUGS“. In Futuristic Trends in Biotechnology Volume 3 Book 13, 241–50. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bjbt13p2ch7.

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One of the greatest threats to global public health today is the growth of multidrug-resistant (MDR) microbial diseases, with 10 million deaths predicted by 2050 if nothing is done. Science and medicine have been changed by nanotechnology. Nanotechnology is becoming more and more important. The unique characteristics of nanoparticles enhance the biological, chemical, and physical qualities investigated for numerous applications. The use of simple formulations, pure molecules that have been retro-synthesized, primarily from herbal sources, and have fewer side effects is receiving major attention in the synthesis of nanoscale modulators. In order to create nanoparticles, green chemistry has developed a tangential method for synthesizing metals and metal oxides. As reducing intermediates, bacteria, fungi, and yeast are combined with plant extracts (leaves, stems, and shoots) to create nanoparticles.Microbiology research has demonstrated that nanoparticles can eliminate bacteria, fungus, viruses, and protozoa. These antibacterial, antifungal and anti-inflammatory properties are present in these green nanoparticles. The majority of nanoparticles have strong antibacterial characteristics, indicating they could be employed to fight biological pollutants and illnesses. These nanoparticles have an antimicrobial effect on pathogenic microbes, including pathogens that are multidrug-resistant and cause significant diseases. The current study will open the door to enhanced nanoparticle production techniques and future applications, opening the door to a novel path in Nano-life sciences that will gain general acceptance.

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Konferenzberichte zum Thema "Multidrug nanoparticles"

Sabir, Dana. „SYNERGISTIC EFFECT OF SILVER NANOPARTICLES COMBINED WITH DIFFERENT ANTIBIOTICS AGAINST MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII STRAIN H72721“. In International Conference of Natural Science. Presidency of Charmo University, 2018. http://dx.doi.org/10.31530/17028.

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Yuvasree, P., K. Nithya und N. Neelakandeswari. „Biosynthesis of silver nanoparticles from Aloe vera plant extract and its antimicrobial activity against multidrug resistant pathogens“. In International Conference on Advanced Nanomaterials & Emerging Engineering Technologies (ICANMEET-2013). IEEE, 2013. http://dx.doi.org/10.1109/icanmeet.2013.6609241.

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Wang, Xu, Jun Li, Yuxiang Wang, Lydia Koenig, Ada Gjyrezi, Paraskevi Giannakakou, Edwin H. Shin et al. „Abstract LB-196: A folate receptor-targeted nanoparticle minimizes multidrug resistance in human cancer xenograft model“. In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-196.

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