Thematische Bibliographien / Mpny

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Auswahl der wissenschaftlichen Literatur zum Thema „Mpny“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 17. Februar 2022

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Zeitschriftenartikel zum Thema "Mpny"

Hermouet, Sylvie, Eric Lippert, Niels Pallisgaard, Jiri Schwarz, Mary Frances McMullin, Lars Palmqvist, Heike L. Pahl et al. „First Achievements of MPN&MPNr-EuroNet (COST Action BM0902), a New European Network Dedicated to the Diagnosis of Myeloproliferative Neoplasms and Hereditary Erythrocytosis and Thrombocytosis“. Blood 118, Nr. 21 (18.11.2011): 2809. http://dx.doi.org/10.1182/blood.v118.21.2809.2809.

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Abstract Abstract 2809 Background: The MPN&MPNr-EuroNet network, created in November 2009, is supported by the European program COST (CoOperation in Science and Technology). It is open to all colleagues active in the fields of myeloprolifeative neoplasms (MPN) and related hereditary diseases (MPNr: hereditary erythrocytosis and thrombocytosis). AIMS: To facilitate, improve and innovate in the diagnosis of MPN and hereditary erythrocytosis and thrombocytosis in Europe. Methods: MPN&MPNr-EuroNet has formed 4 working groups (WG): WG 1 focuses on JAK2 -mutated MPN; WG 2 is dedicated to thrombocythemia and myelofibroses without mutation of JAK2 and includes subgroups specialized in hereditary thrombocytosis (HT) and in histopathology; WG 3 is dedicated to hereditary erythrocytosis (HE); WG 4 is responsible for scientific cooperation and the diffusion of scientific knowledge. Results: During the first 18 months of MPN&MPNr-EuroNet activity, 77 colleagues from 19 countries (16 European countries plus Israel, Turkey, and the USA), joined the network and participated in the four WG, resulting in the achievements listed below. WG 1: 1) determination of the best JAK2 V617F assays, a joint MPN&MPNr-EuroNet/European LeukemiaNet project; 2) on-going study of MPN cases with low JAK2 V617F burden; 3) on-going study of MPN cases with multiple JAK2 mutation. WG 2: 1) list of laboratories responsible for the diagnosis of MPL and THPO mutations in Europe; 2) first international quality test of the detection of MPL mutations; 3) on-going study of new THPO and MPL mutations in HT cases; 4) on-going study of the histopathology of MPN without JAK2 mutation. WG 3: 1) list of laboratories responsible for the diagnosis of HE in Europe; 2) consensus on a diagnostic algorithm for the diagnosis of HE; 3) close interaction with COST Action TD0901 (HypoxiaNet) to facilitate the discovery of new genes of interest for the diagnosis of HE; 4) exchange of positive control samples for the main mutations responsible for HE; 5) study of idiopathic erythrocytosis. WG 4: 1) MPN&MPNr-EuroNet website: www.mpneuronet.eu; 2) organization of bi-annual meetings (5th meeting: March 7–9, 2012, Belfast, United Kingdom); 3) organization of annual training schools: a May training school dedicated to the molecular detection of JAK2 and MPL mutations (in Nîmes, France), and an October training school dedicated to hereditary erythrocytosis (in Coimbra, Portugal); 4) financial support for short term scientific missions for exchange and collaborative studies between participating institutions. Conclusion: MPN&MPNr-EuroNet will enable European researchers, biologists and clinicians to define new diagnostic tools and exchange technologies. MPN&MPNr-EuroNet is open to all interested physicians and scientists and we invite new members, including those from outside Europe, to join. Scholarships are available to finance participation in meetings and training schools, and to facilitate exchanges between participating institutions. For detailed information on all MPN&MPNr-EuroNet activities, see www.mpneuronet.eu. Disclosures: Schnittger: MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Vannucchi:Novartis: Honoraria.

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Mead, Adam J., und Ann Mullally. „Myeloproliferative neoplasm stem cells“. Blood 129, Nr. 12 (23.03.2017): 1607–16. http://dx.doi.org/10.1182/blood-2016-10-696005.

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Abstract Myeloproliferative neoplasms (MPNs) arise in the hematopoietic stem cell (HSC) compartment as a result of the acquisition of somatic mutations in a single HSC that provides a selective advantage to mutant HSC over normal HSC and promotes myeloid differentiation to engender a myeloproliferative phenotype. This population of somatically mutated HSC, which initiates and sustains MPNs, is termed MPN stem cells. In >95% of cases, mutations that drive the development of an MPN phenotype occur in a mutually exclusive manner in 1 of 3 genes: JAK2, CALR, or MPL. The thrombopoietin receptor, MPL, is the key cytokine receptor in MPN development, and these mutations all activate MPL-JAK-STAT signaling in MPN stem cells. Despite common biological features, MPNs display diverse disease phenotypes as a result of both constitutional and acquired factors that influence MPN stem cells, and likely also as a result of heterogeneity in the HSC in which MPN-initiating mutations arise. As the MPN clone expands, it exerts cell-extrinsic effects on components of the bone marrow niche that can favor the survival and expansion of MPN stem cells over normal HSC, further sustaining and driving malignant hematopoiesis. Although developed as targeted therapies for MPNs, current JAK2 inhibitors do not preferentially target MPN stem cells, and as a result, rarely induce molecular remissions in MPN patients. As the understanding of the molecular mechanisms underlying the clonal dominance of MPN stem cells advances, this will help facilitate the development of therapies that preferentially target MPN stem cells over normal HSC.

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Hasselbalch, Hans Carl, Margitta Elvers und Andrew I. Schafer. „The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms“. Blood 137, Nr. 16 (22.04.2021): 2152–60. http://dx.doi.org/10.1182/blood.2020008109.

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Abstract Thrombotic, vascular, and bleeding complications are the most common causes of morbidity and mortality in the Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs). In these disorders, circulating red cells, leukocytes, and platelets, as well as some vascular endothelial cells, each have abnormalities that are cell-intrinsic to the MPN driver mutations they harbor (eg, JAK2 V617F). When these cells are activated in the MPNs, their interactions with each other create a highly proadhesive and prothrombotic milieu in the circulation that predisposes patients with MPN to venous, arterial, and microvascular thrombosis and occlusive disease. Bleeding problems in the MPNs are caused by the MPN blood cell-initiated development of acquired von Willebrand disease. The inflammatory state created by MPN stem cells in their microenvironment extends systemically to amplify the clinical thrombotic tendency and, at the same time, preferentially promote further MPN stem cell clonal expansion, thereby generating a vicious cycle that favors a prothrombotic state in these diseases.

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Smalberg, Jasper H., Lidia R. Arends, Dominique C. Valla, Jean-Jacques Kiladjian, Harry L. A. Janssen und Frank W. G. Leebeek. „Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis“. Blood 120, Nr. 25 (13.12.2012): 4921–28. http://dx.doi.org/10.1182/blood-2011-09-376517.

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Abstract Myeloproliferative neoplasms (MPNs) are the most common cause of Budd-Chiari syndrome (BCS) and nonmalignant, noncirrhotic portal vein thrombosis (PVT). In this meta-analysis, we determined the prevalence of MPNs and their subtypes as well as JAK2V617F and its diagnostic role in these uncommon disorders. MEDLINE and EMBASE databases were searched. Prevalence of MPNs, JAK2V617F, and MPN subtypes were calculated using a random-effects model. A total of 1062 BCS and 855 PVT patients were included. In BCS, mean prevalence of MPNs and JAK2V617F was 40.9% (95% CI, 32.9%-49.5%) and 41.1% (95% CI, 32.3%-50.6%), respectively. In PVT, mean prevalence of MPNs and JAK2V617F was 31.5% (95% CI, 25.1%-38.8%) and 27.7% (95% CI, 20.8%-35.8%), respectively. JAK2V617F and MPNs were more frequent in BCS compared with PVT (P = .03 and P = .09, respectively). Polycythemia vera was more prevalent in BCS than in PVT (P = .001). JAK2V617F screening in splanchnic vein thrombosis (SVT) patients without typical hematologic MPN features identified MPN in 17.1% and 15.4% of screened BCS and PVT patients, respectively. These results demonstrate a high prevalence of MPNs and JAK2V617F in SVT patients and show differences in underlying etiology between these disorders. Furthermore, these results validate routine inclusion of JAK2V617F in the diagnostic workup of SVT patients.

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Kim, Eunhee, und Omar Abdel-Wahab. „Focus on the epigenome in the myeloproliferative neoplasms“. Hematology 2013, Nr. 1 (06.12.2013): 538–44. http://dx.doi.org/10.1182/asheducation-2013.1.538.

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Abstract The discovery of mutations activating JAK-STAT signaling in the majority of patients with myeloproliferative neoplasms (MPNs) led to identification of tyrosine kinase activation as a predominant mechanism driving MPN pathogenesis. Despite this, the existence of additional genetic events that modify the MPN phenotype, predate JAK2 mutations, and/or contribute to leukemic transformation of MPNs has been suggested. Recently, mutations in several epigenetic modifiers have been described in patients with MPNs, including mutations in ASXL1, DNMT3A, EZH2, IDH1, IDH2, and TET2. Moreover, the mutant JAK2 itself has been shown recently to affect histone posttranslational modifications directly. Here we review the biological and clinical implications of epigenetic alterations in the pathogenesis of MPNs.

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Xu, Yue, Changxin Yin, Han He, Lingling Shu, Fuqun Wu, Fanyi Meng, Beng Chong und Mo Yang. „Analysis of JAK2 V617F Mutation and Its Clinical Significance in Patients with Thrombocythemia and Other Myeloproliferative Neoplasms in Chinese“. Blood 118, Nr. 21 (18.11.2011): 4687. http://dx.doi.org/10.1182/blood.v118.21.4687.4687.

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Abstract Abstract 4687 JAK2 mutation is commonly found in Philadelphia-negative myeloproliferative neoplasms (MPNs). In Western countries, this mutation is found in approximately 96 percent of people with polycythemia vera, half of individuals with essential thrombocythemia or primary myelofibrosis. We used the method of amplification refractory mutation PCR (ARMS-PCR) to investigate MPN patients in China. We focused our study on patients with essential thrombocythemia (ET). ARMS-PCR was used to detect JAK2 V617F mutation in the bone barrow (BM) or peripheral blood of 37 MPN patients, which consisting of 7 ET, 5 polycythemia vera (PV), 5 chronic myeloid leukemia (CML), 5 chronic idiopathic myelofibrosis (CIMF), as well as 15 suspected MPNs. 17 cases of JAK2 V617F mutation (45.9%) were found in 37 patients, including 4 ET (57.1%), 4 PV (80.0%), 3 CIMF (60.0%), 6 suspected MPNs (40.0%). We did not find JAK2 V617F in the patients with CML. Our results indicated that the frequency of JAK2 V617F mutation in bcr/abl-negative MPNs in Chinese is similar to that in MPN patients in Western countries. At the same time, ARMS-PCR can distinguish the mutation is heterozygous or homozygous. Most patients were heterozygous for JAK2 but only a few were homozygous. In conclusion, our study showed that JAK2 V617F mutation frequency in Chinese MPN patients is similar to that in patients with this disorder in the West. It is the major molecular genetic abnormality in bcr-abl negative MPN and it can be used for diagnosis of MPN in China. Disclosures: No relevant conflicts of interest to declare.

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Zhang, Su-Jiang, Raajit Rampal, Taghi Manshouri, Jay Patel, Nana Mensah, Andrew Kayserian, Todd Hricik et al. „Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome“. Blood 119, Nr. 19 (10.05.2012): 4480–85. http://dx.doi.org/10.1182/blood-2011-11-390252.

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Abstract Leukemic transformation (LT) of myeloproliferative neoplasms (MPNs) is associated with a poor prognosis and resistance to therapy. Although previous candidate genetic studies have identified mutations in MPN patients who develop acute leukemia, the complement of genetic abnormalities in MPN patients who undergo LT is not known nor have specific molecular abnormalities been shown to have clinical relevance in this setting. We performed high-throughput resequencing of 22 genes in 53 patients with LT after MPN to characterize the frequency of known myeloid mutations in this entity. In addition to JAK2 and TET2 mutations, which occur commonly in LT after MPN, we identified recurrent mutations in the serine/arginine-rich splicing factor 2 (SRSF2) gene (18.9%) in acute myeloid leukemia (AML) transformed from MPNs. SRSF2 mutations are more common in AML derived from MPNs compared with LT after myelodysplasia (4.8%) or de novo AML (5.6%), respectively (P = .05). Importantly, SRSF2 mutations are associated with worsened overall survival in MPN patients who undergo LT in univariate (P = .03; HR, 2.77; 95% CI, 1.10-7.00) and multivariate analysis (P < .05; HR, 2.11; 95% CI, 1.01-4.42). These data suggest that SRSF2 mutations contribute to the pathogenesis of LT and may guide novel therapeutic approaches for MPN patients who undergo LT.

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How, Joan, Amy Zhou und Stephen T. Oh. „Splanchnic vein thrombosis in myeloproliferative neoplasms: pathophysiology and molecular mechanisms of disease“. Therapeutic Advances in Hematology 8, Nr. 3 (08.12.2016): 107–18. http://dx.doi.org/10.1177/2040620716680333.

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Myeloproliferative neoplasms (MPNs) are the most common underlying prothrombotic disorder found in patients with splanchnic vein thrombosis (SVT). Clinical risk factors for MPN-associated SVTs include younger age, female sex, concomitant hypercoagulable disorders, and the JAK2 V617F mutation. These risk factors are distinct from those associated with arterial or deep venous thrombosis (DVT) in MPN patients, suggesting disparate disease mechanisms. The pathophysiology of SVT is thought to derive from local interactions between activated blood cells and the unique splanchnic endothelial environment. Other mutations commonly found in MPNs, including CALR and MPL, are rare in MPN-associated SVT. The purpose of this article is to review the clinical and molecular risk factors for MPN-associated SVT, with particular focus on the possible mechanisms of SVT formation in MPN patients.

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Ramanathan, Gajalakshmi, Brianna M. Hoover und Angela G. Fleischman. „Impact of Host, Lifestyle and Environmental Factors in the Pathogenesis of MPN“. Cancers 12, Nr. 8 (24.07.2020): 2038. http://dx.doi.org/10.3390/cancers12082038.

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Philadelphia-negative myeloproliferative neoplasms (MPNs) occur when there is over-production of myeloid cells stemming from hematopoietic stem cells with constitutive activation of JAK/STAT signaling, with JAK2V617F being the most commonly occurring somatic driver mutation. Chronic inflammation is a hallmark feature of MPNs and it is now evident that inflammation is not only a symptom of MPN but can also provoke development and precipitate progression of disease. Herein we have considered major MPN driver mutation independent host, lifestyle, and environmental factors in the pathogenesis of MPN based upon epidemiological and experimental data. In addition to the traditional risk factors such as advanced age, there is evidence to indicate that inflammatory stimuli such as smoking can promote and drive MPN clone emergence and expansion. Diet induced inflammation could also play a role in MPN clonal expansion. Recognition of factors associated with MPN development support lifestyle modifications as an emerging therapeutic tool to restrain inflammation and diminish MPN progression.

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Masselli, Elena, Giulia Pozzi, Giuliana Gobbi, Stefania Merighi, Stefania Gessi, Marco Vitale und Cecilia Carubbi. „Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants“. Cells 9, Nr. 9 (21.09.2020): 2136. http://dx.doi.org/10.3390/cells9092136.

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Among hematologic malignancies, the classic Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related cancer development. In this context, the use of immune-modulating agents has recently expanded the MPN therapeutic scenario. Cytokines are key mediators of an auto-amplifying, detrimental cross-talk between the MPN clone and the tumor microenvironment represented by immune, stromal, and endothelial cells. This review focuses on recent advances in cytokine-profiling of MPN patients, analyzing different expression patterns among the three main Philadelphia-negative (Ph-negative) MPNs, as well as correlations with disease molecular profile, phenotype, progression, and outcome. The role of the megakaryocytic clone as the main source of cytokines, particularly in myelofibrosis, is also reviewed. Finally, we report emerging intriguing evidence on the contribution of host genetic variants to the chronic pro-inflammatory state that typifies MPNs.

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Dissertationen zum Thema "Mpny"

Markulchak, Alina. „Návrh projektu a aplikace metodiky projektového managementu v podniku“. Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2021. http://www.nusl.cz/ntk/nusl-444613.

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Ths bhlr thss s fusd n prjt mngmnt n n th sltd mpny. Th frst prt f th thss dsrbs th thrtl knwldg f prjt mngmnt. Th snd nlytl prt s dvtd t th bs nfrmtn but th mpny nd th nlyss f th urrnt stutn n th mpny. Th lst prt f wrk nluds suggstns fr hngs n th mpny nd dsrbs th bnfts f ths hngs.

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Lamrani, Lamia. „Etude de l'hémostase dans les néoplasies myeloprolifératives (MPN)“. Paris 7, 2014. http://www.theses.fr/2014PA077178.

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Les néoplasies myéloprolifératives (MPN) Ph-négatifs sont des anomalies clonales des cellules souches hématopoïétiques provoquant une prolifération massive de cellules sanguines et plusieurs manifestations cliniques: la Polyglobulie de Vaquez (PV) et la Thrombocytémie essentielle (TE) affectent respectivement les lignées érythrocytaire et mégacaryocytaire ; la myélofibrose primitive consiste en un enrichissement de la moelle osseuse en collagène. Des troubles de l'hémostase ont été rapportés avec en particulier des risques de thromboses élevés qui sont la première cause de mortalité chez les patients MPN. Des facteurs de risques de thrombose sont identifiés mais l'étude de la pathogénie est limitée par l'hétérogénéité des patients et les traitements prophylactiques. Notre objectif principal a été de déterminer l'effet de la mutation JAK2v617F, retrouvée fréquemment chez les patients MPN, sur l'hémostase et la thrombose. Dans des modèles murins mimant une PV, nous avons observés des dysfonctions complexes de l'hémostase non directement liés à l'expression de JAK2v6I7F. Cette étude nous a permis d'élaborer une stratégie pour étudier l'impact des traitements sur l'activation plaquettaire et endothéliale, sur une cohorte de patients MPN. Nos résultats préliminaires suggèrent que l'interféron alpha a un impact sur l'hémostase. Ces résultats, intégrés à l'ensemble de données récentes, ouvrent de nouvelles perspectives sur le mécanisme des thromboses
Myeloproliferative neoplasms (MPN) Ph-negative are clonai disorders of hematopoietic stem cells characterized by the predominant proliferation of the erythrocyte lineage in PV and of the megakaryocyte lineage in ET. In primary myelofibrosis the bone marrow is invaded by collagen leading to pancytopenia. Thrombosis episodes are frequent in MPN and represent the major cause of morbidity and mortality. Some risks factors have been identified but the pathophysiology is difficult to establish due to the heterogeneity of MPN patients. The aim of this work was to determine the effect of a mutation frequently found in MPN (JAK2v617F) on hemostasis and thrombosis. In mice models of PV, we evidenced complex and opposite hemostasis defects that were not directly linked to the expression of the mutation. This study allowed us to develop a strategy to conduct a clinical study to analyze the impact of treatments on piatelet and endothelial activation in a cohort of MPN patients. Our preliminary data suggest that alpha-interferon may impact hemostasis in MPN patients. These resuits and other recent data open new perspectives on mechanisms leading to thrombosis

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Tran, Huong Jade Thien Thi. „Structural and functional studies of JAB1/MPN domain proteins“. Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614104.

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`Arnold, Claire. „Intracellular signalling pathways in myeloproliferative neoplasms“. Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680884.

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Calero, Ana Gabriela. „Application of molecular detection methods to most probable number (MPN) enumeration of Vibrio vulnificus in oysters“. [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0002740.

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Dekaki, Anouar. „Impact de l'utilisation d'un compost vert sur l'activité et la diversité de la microflore tellurique“. Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0058/document.

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Le compostage est une technique de valorisation des déchets organiques en un produit stable et riche en matières humiques. Certains composts « verts » se sont révélés être de 2 à 3 fois plus efficaces sur la croissance des plantes que les composts classiques. Notre étude réalisée sur un compost fabriqué à partir de déchets végétaux a permis de suivre l’évolution de la densité et de la diversité de la microflore (bactéries, champignons) au cours du processus de maturation puis de tester l’impact de ce compost sur la diversité et l’activité de la microflore tellurique. Cette analyse a été effectuée par des techniques complémentaires : biochimiques (dosages enzymatiques), microbiologiques (cultures in vitro) et de biologie moléculaire (PCR-DGGE, Séquençage). Les résultats montrent qu’au cours de sa maturation, le compost étudié présente une baisse significative de son taux d’humidité et une augmentation sensible de son pH. Sa microflore subit une complète restructuration avec apparition de souches bactériennes susceptibles de dégrader des composés polluants comme les plastiques, les pesticides et les hydrocarbures. L’ajout de ce compost à deux types de sol présentant des propriétés physico-chimiques différentes, n’a pas montré de modifications importantes et durables de la diversité microbienne et fonctionnelle de celui-ci. Les causes de l’effet remarquable de ce compost sur la croissance végétale sont discutées
Composting is a technique of transformation organic waste in a stable product rich in organic materials. Some "green" compost proved to be from 2 to 3 times more benefit on the growth of the plants than traditional composts. The main of this study is to follow the evolution of density and diversity of the microflora (bacteria, fungi) during the process of maturation of green compost manufactured from vegetable wastes, and to investigate the impact of this compost on the diversity and the activity of the telluric microflora. This analysis was carried out by complementary techniques: biochemical (enzymatic activity), microbiological (in vitro cultures) and molecular biology (PCR-DGGE, DNA sequencing). The results show that during its maturation, the studied compost presents a significant decrease of its water content and an appreciable increase in its pH. The microflora undergoes a complete reorganization with appearance of bacterial strain suitable for degrade polluting compounds like the plastics, the pesticides and hydrocarbons. The addition of this compost with two types of soil presenting of the different physicochemical properties, did not show significant and durable modifications of the microbial and functional diversity of this one. The causes of the remarkable effect of this compost on the vegetable growth are discussed

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Flodin, Jessica. „Validation of Steins/Arla Foods method for lactate fermenting clostridia in milk“. Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109248.

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One of the most serious and economically important defects caused by clostridia in milk products is the late blowing of semi-hard cheeses.

Clostridia occur naturally in soil and can contaminate milk through crops contaminated by dung and soil followed by a less successful silage process, that give them opportunity to grow unaerobically. When anaerobic conditions occur, such as storage of semi-hard cheese, they ferment lactic acid to butyric acid and the gases CO₂ and H₂.

At the fusion of Arla and MD Foods, a series of changes were conducted on the MPN method for lactic acid fermentation for clostridia in milk. These changes resulted in an increased accuracy due to an increased number of test tubes and the change of media from MRCM to BBB, Bryant & Burkey Broth, that was thought to be more selective for Cl. tyrobutyricum, the organism mostly found in hard cheese. When the number of dairy farmers that were given quality reduction fines increased, the new method was suspected and a validation was conducted.

The validation included inoculation of different clostridia and bacillus strains into BBB substrate and enzymatic testing of positive samples with Rapid ID 32A. The inoculation result showed that almost all tested different clostridia strains could grow in BBB substrate.

Test on BBB positive tubes with Rapid ID 32A resulted in 95% clostridia of which 70% was Cl. tyrobutyricum. These results correlated well with earlier studies on MRCM substrate and the increase in quality reduction fines probably depended on the larger number of test tubes used in the new method rather than the change of substrate.

Clostridier eller främst Cl. tyrobutyricum är den art som i de flesta fall orsakar feljästa ellersönderjästa ostar, vilket är ett välkänt problem inom mejeriindustrin. Clostridiesporer finns naturligt i jord och hamnar i mjölkråvaran via gröda som kontaminerats med gödsel och jord och som tillsammans med en mindre lyckad ensileringsprocess gör att clostridierna växer till. När anaeroba förhållanden uppstår, såsom vid lagring av hårdost, förjäser clostridierna laktat och smörsyra varvid vätgas och koldioxid bildas.

I samband med fusionen av Arla/MD Foods, genomfördes metodförändringar för MPN-metoden för laktatjäsande clostridier i mjölk, som används inom mjölkbedömningen. Dessa förändringar innebar en skärpning i noggrannheten genom att man ökade antal rör, samt ett substratbyte från MRCM till BBB, Bryant & Burkey Broth, som ansågs mer gynnsamt för Cl. tyrobutyricum.

Då antalet mjölkproducenter som fick kvalitetsavdrag ökade, riktades misstankar mot den nya metoden och en validering genomfördes.

Resultatet av valideringen, som innebar ympning av renkulturer, utodling av positiva rör med efterföljande typning, visade att de flesta av de tillsatta stammarna av clostridier hade förmågan att ge ett positivt utslag vid tillsats av renkulturer. Utodling och typning av positiva rör visade att ca 70 % av de positiva utslagen innehöll Cl. tyrobutyricum och hela 95 % någon clostridieart. Dessa resultat korrelerar med tidigare studier på MRCM-substrat och ökningen av positiva utslag berodde troligtvis på det ökade antalet rör som den nya metoden innebar.

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Baumeister, Julian [Verfasser], Wolfgang [Akademischer Betreuer] Wagner und Steffen [Akademischer Betreuer] Koschmieder. „Dissecting the role of hypoxia-inducible factor 1 (HIF-1) in JAK2V617F-positive myeloproliferative neoplasms (MPN) / Julian Baumeister ; Wolfgang Wagner, Steffen Koschmieder“. Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1218788062/34.

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Gaskin, Sharyn, und sharyn gaskin@flinders edu au. „Rhizoremediation of hydrocarbon contaminated soil using Australian native grasses“. Flinders University. Medicine, 2009. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20090820.111303.

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The breakdown of contaminants in soil resulting from microbial activity that is enhanced in the presence of the plant root zone, rhizosphere, has been termed rhizoremediation. To date, Australian native plants have not been assessed for their hydrocarbon rhizoremediation potential. The use of native plants offers an economically feasible and environmentally sustainable cleanup option for the rehabilitation and restoration of hydrocarbon contaminated sites in Australia. The aim of the study was to evaluate the potential of Australian native grass species for the rhizoremediation of aliphatic hydrocarbon contaminated soil from a mine site. Candidate Australian native grass species Poaceae were selected following the development of essential and desirable growth criteria. Nine perennial Australian grasses were evaluated for seedling emergence in sandy loam soil sourced from a mine site which was artificially contaminated with a 60:40 diesel/oil mix at concentrations of 30 000 mg/kg, 10 000 mg/kg, 5 000 mg/kg and 0 mg/kg control. Seedling emergence was not adversely affected by the presence of hydrocarbon contamination at the exposed concentrations for eight of the nine species studied p > 0.05. Three promising species were assessed for relative growth performance in diesel/oil contaminated 10 000 mg/kg, 5 000 mg/kg and uncontaminated control soils in greenhouse studies to assess their tolerance of aliphatic hydrocarbon contaminated soil. Cymbopogon ambiguus Lemon Scented grass is a summer growing perennial with widespread distribution throughout Australia including the region where the mine site is situated. Brachiaria decumbens Signal grass naturalised - is adapted to humid tropical areas of Australia and is native to the site and sourced from seed banks. Microlaena stipoides Weeping grass var. Griffin is a cool season grass, widely distributed throughout Australia in moister regions. The three evaluated species survived for 120 days in the diesel/oil contaminated soil at the exposed concentrations without adverse growth affect p > 0.05. In some instances e.g. C. ambiguus growth stimulation occurred in the presence of contamination producing significantly more root biomass compared with the control p < 0.0001. Most hydrocarbon degradation is believed to occur through microbial processes, and so the plant-associated microbial community was examined in the three tolerant species. The assessment of the influence of grass on the abundance and activity of microorganisms in the rhizosphere revealed species-specific plant-induced changes in the soil microbial community. Selective enrichment of hydrocarbon degrading microorganisms was demonstrated in the rhizosphere soil of the Australian grasses tested, to varying degrees. C. ambiguus appeared to have the greatest influence on stimulation of hydrocarbon degrading microorganisms, followed by the cool season grass M. stipoides. B. decumbens showed consistently lower numbers of hydrocarbon degrading microorganisms in rhizosphere soil over time compared to the other two species p < 0.01. The influence of grasses on microbial community structure - defined as community DNA fingerprint - in diesel/oil contaminated soil suggested no new microbial population was favoured by the grasses - qualitative shift - rather there were relative quantitative changes in existing members of the microbial population. Soil lipase activity did not appear to be an optimal bioindicator of rhizoremediation and may encompass total soil microbial activity not exclusively the hydrocarbon degrading microorganisms of interest. The assessment of biodegradation of hydrocarbons in soil is essential to characterise the effectiveness of plant species in rhizoremediation. Residual diesel and oil concentrations as total petroleum hydrocarbons, TPH were measured using Gas Chromatography. The presence of single species successfully enhanced the removal of hydrocarbons from soil for all species. All showed significantly lower residual hydrocarbon concentrations than those in unplanted soil after 100 days p < 0.01. Significantly, it was not necessary to add N and P to achieve up to 90% reduction in hydrocarbon concentrations in the soil. The relative performance of each grass species varied. In soil planted with C. ambiguus hydrocarbon concentrations were reduced faster and to a greater extent than the other species studied, from 10 000 mg/kg to approximately 1 100 mg/kg TPH, 88% removal. Similar endpoint success was recorded for M. stipoides which facilitated 80% reduction in hydrocarbon concentrations. Interestingly, B. decumbens, the only naturalised species, did not perform as well as the other species, although still significantly better compared to unplanted controls, with hydrocarbon concentrations reduced to approximately 4 500 mg/kg, 49%. Hydrocarbon concentrations in unplanted control soil were reduced by 45% through natural biodegradation processes. Plant root and shoot tissue was periodically assessed for hydrocarbon accumulation and was shown to be negligible. A multispecies planted trial using C. ambiguus plus B. decumbens had no additional influence on total TPH removal. The final TPH removal efficiency in the multispecies trial was not significantly different p > 0.05 from that of the best single species performer of the two i.e. C. ambiguus. In a field application the planting of multiple species may still be desirable in order to preserve site biodiversity and assist rehabilitation of the area. A strong relationship between abundance of hydrocarbon degrading microorganisms in the rhizosphere and hydrocarbon biodegradation was demonstrated for all species p < 0.01. Those species which showed greatest stimulation of the microbial population resulted in enhanced TPH removal from soil. These species were the summer grass C. ambiguus and the winter species M. stipoides. This may allow for broader application both seasonally and geographically across Australia. B. decumbens showed successful rhizoremediation to a lesser degree, but may still be an option in multiple planting strategies. This investigation identified three Australian grass species from the nine evaluated that are candidates for further investigation for in situ rhizoremediation potential at field scale.

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Abley, Melanie J. „Tracking, Quantifying, Phenotyping and Genotyping of Campylobacter in Cattle and Pigs across the Farm to Fork Continuum“. The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306427015.

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Bücher zum Thema "Mpny"

Thee mpty house. London: Severn House, 1985.

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Guay, Roger. Development of a modified MPN procedure to enumerate iron oxidizing bacteria: Final report. Ottawa, Ont: Canada Centre for Mineral and Energy Technology = Centre canadien de la technologie des minéraux et de l'énergie, 1993.

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Provan, Drew, Trevor Baglin, Inderjeet Dokal und Johannes de Vos. Myeloproliferative neoplasms. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0007.

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Myeloproliferative neoplasms (MPNs) - Pathogenesis of the MPNs - Polycythaemia vera (PV) - Natural history of PV - Management of PV - Secondary erythrocytosis - Relative erythrocytosis - Idiopathic erythrocytosis - Essential thrombocythaemia - Reactive thrombocytosis - Primary myelofibrosis - Chronic neutrophilic leukaemia - Eosinophilic syndromes and neoplasms - Mastocytosis (mast cell disease) - Systemic mastocytosis - MPN—unclassifiable

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Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos und Mammit Kaur. Myeloproliferative neoplasms. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199683307.003.0007_update_001.

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Barnett. Syringomyelia Mpn. W.B. Saunders Company, 1997.

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Linet, Martha S., Lindsay M. Morton, Susan S. Devesa und Graça M. Dores. Leukemias. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0038.

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The 2001 World Health Organization (WHO) classification of hematopoietic and lymphoid neoplasms categorized “the leukemias” into two major groupings—myeloid and lymphoid. Myeloid neoplasms, which are the primary focus of this chapter, include acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN). Lymphoid neoplasms are mostly reviewed as part of non-Hodgkin lymphoma in Chapter 40 of this volume, although descriptive patterns and selected etiologic studies are briefly discussed in this chapter because of historical trends. Worldwide, leukemias are ranked eleventh among all cancer types, comprising approximately 2.5% of all malignancies. Exposure to ionizing radiation and certain chemical carcinogens (e.g., cytotoxic chemotherapy, benzene, formaldehyde) are the most consistently associated risk factors for MDS and/or AML. Radiation has been linked with CML, and cigarette smoking with AML. Fewer risk factors have been identified for MPNs. Some evidence implicates increased risks of AML in rubber workers, farmers, and other agricultural workers.

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Abrams. Discoveries 12 Copy Display E Mpty. HNA Books, 1992.

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Reich und Cannistraro. The Western Perspective Mpn. Wadsworth Pub Co, 2003.

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Simplificado Assortment-American Wholesale Book Co Mpany. John Wiley and Sons, 1999.

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Co mpany awareness: A custom research study. [Montvale, N.J.]: Medical Economics Pub., 1993.

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Buchteile zum Thema "Mpny"

Bhargava, Manorama. „Myeloproliferative Neoplasms (MPNs)“. In Hematologic Malignancies, 133–38. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4799-1_6.

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Liu, Dongyou. „Myeloproliferative Neoplasms (MPN)“. In Tumors and Cancers, 81–90. Boca Raton : Taylor & Francis, a CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc, 2018. | Series: Pocket guides to biomedical sciences: CRC Press, 2017. http://dx.doi.org/10.1201/9781315120546-15.

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Engelhardt, Monika, Dietmar P. Berger, Roland Mertelsmann und Justus Duyster. „Myeloproliferative Neoplasien (MPN)“. In Das Blaue Buch, 99–111. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-51420-7_3.

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Engelhardt, Monika, Roland Mertelsmann und Justus Duyster. „Myeloproliferative Neoplasien (MPN)“. In Das Blaue Buch, 95–104. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-60380-2_4.

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Löffler, Helmut, und Torsten Haferlach. „Myeloproliferative Neoplasien (MPN)“. In Hämatologische Erkrankungen, 81–109. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-29535-5_8.

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Engelhardt, Monika, Dietmar Berger und Roland Mertelsmann. „Myeloproliferative Neoplasien (MPN)“. In Das Blaue Buch, 35–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-20626-9_3.

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Beham-Schmid, Christine, und Annette Schmitt-Graeff. „Myeloproliferative Neoplasm (MPN)“. In Essentials of Diagnostic Pathology, 253–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-60309-3_9.

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Engelhardt, Monika, Dietmar Berger, Justus Duyster und Roland Mertelsmann. „Myeloproliferative Neoplasien(MPN)“. In Das Blaue Buch, 37–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41741-2_3.

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Onieva, José A., Javier Lopez und Jianying Zhou. „New Design Approaches for MPNR“. In Secure Multi-Party Non-Repudiation Protocols and Applications, 1–47. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-75630-1_4.

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Onieva, José A., Javier Lopez und Jianying Zhou. „Scenarios Supported by MPNR Services“. In Secure Multi-Party Non-Repudiation Protocols and Applications, 1–37. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-75630-1_6.

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Konferenzberichte zum Thema "Mpny"

Li, Jianmin, und Krishna C. Gupta. „Mathematical Programming Neural Networks (MPNN) for Mechanism Design“. In ASME 1997 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/detc97/dac-3755.

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Abstract The prevalent Mathematical Programming Neural Network (MPNN) models are surveyed, and MPNN models have been developed and applied to the unconstrained optimization of mechanisms. Algorithms which require Hessian inversion and those which build up a variable approach matrix, are investigated. Based upon a comprehensive investigation of the Augmented Lagrange Multiplier (ALM) method, new algorithms have been developed from the combination of ideas from MPNN and ALM methods and applied to the constrained optimization of mechanisms. A relationship between the weighted least square minimization of design equation error residuals and the mini-max norm of the structure error for function generating mechanisms is developed and employed in the optimization process; as a result, the computational difficulties arising from the direct usage of the complex structural error function have been avoided. The paper presents relevant theory as well as some numerical experience for four MPNN algorithms.

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Cullen, John J., und Hugh L. MacIntyre. „The case for using the Most Probable Number (MPN) method in ballast water management system type approval testing“. In IMarEST Ballast Water Technology Conference. IMarEST, 2017. http://dx.doi.org/10.24868/bwtc6.2017.010.

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Recently, the U.S. Coast Guard (USCG) rejected the Serial Dilution Culture-Most Probable Number (SDC-MPN) method for enumerating viable phytoplankton cells in ballast water discharge as an alternate to their prescribed method — the Environmental Technology Verification (ETV) Protocol. This method distinguishes living from dead organisms using vital stains and motility. Succinctly, the USCG position has been that the ETV Protocol is a reliable and repeatable efficacy test and the SDC-MPN method is not. New evidence and an expanded consideration of published research supports a fundamentally different assessment. A peer-reviewed quantitative evaluation of ETV vital stains for 24 species of phytoplankton has conclusively established that the ETV Protocol, even with observations of motility, is not reliable for all species. In contrast, published results suggest that errors in the method were small for the limited number of locations studied to date. It is possible that the communities tested in these were dominated by species that can be classified accurately using vital stains. Even so, it must be acknowledged that the reliability and accuracy of vital stains is untested for thousands of species of phytoplankton. Introduced in 1951, the SDC-MPN method for phytoplankton is an established approach for use with multi-species communities. As applied to ballast water testing, SDC-MPN is much less vulnerable to methodological uncertainties than has been assumed. Notably, all species of phytoplankton need not be cultured in the conventional sense. Rather, a single viable cell in a dilution tube need grow only enough to be detected — a requirement known to have been met by otherwise uncultured species. Further, delayed restoration of viability after treatment with ultraviolet radiation (UV) is not a problem: organisms repair UV damage quickly or not at all, consistent with the assumptions of the test. Two critical methodological failures could compromise protection of the environment in ballast water testing: living organisms that do not stain or move, and viable organisms that do not grow to detection in the MPN cultures. These can be assessed with complementary measurements, but importantly, the relative protection of each method can be evaluated by comparing counts of living cells from the ETV Protocol with counts of viable cell from SDC-MPN in untreated samples. Available evidence provides no basis for concluding that either method is consistently less protective. However, as applied in ballast water testing, the statistical estimate of MPN is less precise. On this basis, SDC-MPN is worse for a single test. But, counter-intuitively, it is more protective of the environment when five consecutive tests must be passed for type approval, because the likelihood of one false rejection out of five tests is higher and five false passes would be exceedingly rare. Addressing only the science, we conclude that both the ETV Protocol and the SDC-MPN method, though imperfect, are currently appropriate for assessing the efficacy of ballast water management systems in a type-approval testing regime. In closing, we show proof of concept for a rapid assay of viability, benchmarked against SDC-MPN, that could be well suited for routine assessment of treatment system performance.

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Song, Ying, Shuangjia Zheng, Zhangming Niu, Zhang-hua Fu, Yutong Lu und Yuedong Yang. „Communicative Representation Learning on Attributed Molecular Graphs“. In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California: International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/392.

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Constructing proper representations of molecules lies at the core of numerous tasks such as molecular property prediction and drug design. Graph neural networks, especially message passing neural network (MPNN) and its variants, have recently made remarkable achievements in molecular graph modeling. Albeit powerful, the one-sided focuses on atom (node) or bond (edge) information of existing MPNN methods lead to the insufficient representations of the attributed molecular graphs. Herein, we propose a Communicative Message Passing Neural Network (CMPNN) to improve the molecular embedding by strengthening the message interactions between nodes and edges through a communicative kernel. In addition, the message generation process is enriched by introducing a new message booster module. Extensive experiments demonstrated that the proposed model obtained superior performances against state-of-the-art baselines on six chemical property datasets. Further visualization also showed better representation capacity of our model.

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Kral, Martin, Yoichi Tsujita, Satoshi Suzuki, Yasutoshi Yamaichi, Masashi Kando und Marius Gabriel Blajan. „Decapsulation of IC Package by Atmospheric Microwave Plasma Needle“. In ISTFA 2016. ASM International, 2016. http://dx.doi.org/10.31399/asm.cp.istfa2016p0193.

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Abstract We present experimental results of IC package decapsulation carried out using Ar and O2 gas mixture remote plasma generated by atmospheric microwave plasma needle (“a-MPN”). Depth etch rate of up to 6.5 µm/min and volume etch rate of up to 0.1 mm3/min were shown to be obtained by a-MPN process operated at 15 W microwave power. SEM imaging suggested no damage to the bonding wire, pads, or passivation.

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Deshpande, Anirudh, Prashanta Dutta und Soumik Banerjee. „Solubility of Oxygen in Lithium-Air Battery Electrolytes: A Molecular Dynamics Study“. In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-40215.

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Ionic liquids are widely considered as potential electrolytes for lithium batteries due to their tunable electrochemical properties and extremely low vapor pressure, which makes them highly non-inflammable. However, the solubility of oxygen in ionic liquid based electrolytes is an important parameter that determines the performance of batteries. In the present study, we have employed molecular dynamics simulations to calculate the Henry’s constant and corresponding solubility values of atmospheric oxygen in N-methyl-N-propyl pyrrolidinium bis(trifluoromethanesulfonyl) imide (mppy+TFSI−) ionic liquids. After qualitatively validating the results at 323 K, we calculated the solubility of oxygen in mppy+TFSI−, as the ratio of the partial pressure of oxygen gas in the atmosphere and the Henry’s constant, at a range of temperatures that occur in realistic battery electrolytes. The solubility of oxygen increases with increasing temperature. Comparison of these solubility values with those of commonly used organic electrolytes provides valuable information regarding the feasibility of using ionic liquid electrolytes in lithium-air batteries.

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Taofen Li, Shuili Yang und Yu Dong. „Cooperation partners selection for single-core-type MPN“. In 2010 2nd International Conference on Networking and Digital Society (ICNDS). IEEE, 2010. http://dx.doi.org/10.1109/icnds.2010.5479210.

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Tao, Jie, Xiaodong Wang und Xu Liang. „Health State Evaluation for Fuzzy Multi-state Production Systems based on MPNM“. In 2020 11th International Conference on Prognostics and System Health Management (PHM-2020 Jinan). IEEE, 2020. http://dx.doi.org/10.1109/phm-jinan48558.2020.00009.

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Yu, Jiashuo, Ying Cheng und Rui Feng. „MPN: Multimodal Parallel Network for Audio-Visual Event Localization“. In 2021 IEEE International Conference on Multimedia and Expo (ICME). IEEE, 2021. http://dx.doi.org/10.1109/icme51207.2021.9428373.

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Rencuzogullari, Cagla, Sevcan Tug Bozdogan, Birol Guvenc und Atil Bisgin. „Abstract 3125: Disturbance ofCALRmutation profile in MPNs by NGS and Real-Time PCR“. In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3125.

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Bartenstein, Matthias, Lanzhu Yue, Wanke Zhao, Wanting Tina Ho, Cem Murdun, Adam W. Mailloux, Ling Zhang et al. „Abstract 954: TGF-ß signaling inhibition counteracts myelofibrosis in MPN“. In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-954.

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Berichte der Organisationen zum Thema "Mpny"

Karabarbounis, Loukas. The Labor Wedge: MRS vs. MPN. Cambridge, MA: National Bureau of Economic Research, Mai 2013. http://dx.doi.org/10.3386/w19015.

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