Zeitschriftenartikel: „Mouth Diseases Diagnosis“

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Mehbalı oğlu Həmzəyev, Bəhlul, Aytən Əmir qızı Məmmədova, Qələndər Xanlar oğlu Əliyev, Sevda Tariyel qızı Hüseynova und Nailə Sabir qızı Zülfüqarova. „Diseases of internal organs diseases of the mouth mouth much, tongue and lips“. NATURE AND SCIENCE 19, Nr. 4 (19.04.2022): 6–9. http://dx.doi.org/10.36719/2707-1146/19/6-9.

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Ağız boşluğu selikli qişası, dil və dodaqların xəstəlikləri praktiki tibbin vacib və mürəkkəb sahələrindən biridir. Bir çox hallarda pasiyentlər mürəkkəb kliniki situasiyalarla qarşılaşırlar və onlara vaxtında adekvat müalicə tətbiq etmək mümkün olmur. Bəzi hallarda həmin orqanlarda əhəmiyyətsiz görünən hər hansı bir klinik əlamət həkimin nəzarətindən yayınır və bu xırda səhv diaqnostika və müalicə mərhələsində öz neqativ təsirini göstərmiş olur. Açar sözlər: Ağız boşluğu, selikli qişa, sistem xəstəliklər, diaqnostika, müalicə Bahlul Mehbalı Hamzayev Aytan Amir Mammadova Qalandar Xanlar Aliyev Sevda Tariyel Huseynova Naila Sabir Zulfuqarova Diseases of internal organs diseases of the mouth mouth much, tongue and lips Abstract Diseases of the oral mucosa, tongue and lips are one of the most important and complex areas of practical medicine. In many cases, patients face difficult clinical situations and cannot receive adequate treatment in a timely manner. In some cases, any clinical signs that appear in these organs are insignificant, do not depend on the doctor, and this minor error adversely affects the stage of diagnosis and treatment. Key words: Oral cavity, mucous membranes, systemic diseases, diagnosis, treatment

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Pîrvu, Raluca Ema, Ioanina Părlătescu, Șerban Țovaru, Cosmin Dugan und Paula Perlea. „Pitfalls for diagnosis of burning mouth-like syndrome“. Romanian Journal of Stomatology 67, Nr. 3 (30.09.2021): 150–55. http://dx.doi.org/10.37897/rjs.2021.3.3.

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This research gives a scientific framework for burning mouth syndrome(BMS) etiology and diagnostic approach in clinical dental and medical practice. BMS-like symptoms can be induced by systemic diseases such as diabetes, gastrointestinal, endocrine disorders, allergy etc. or by local oral cavity conditions as candidiasis or geographic tongue or odontogenic causes. Because the etiology of BMS is multifactorial, treatment can only be distinctive, and is aimed at relieving symptoms. The complexity of BMS symptoms and associated psychosocial infirmities, anxiety and depression raise the need for a multidisciplinary and individualised approach.

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Clavijo, Alfonso, und Paul Kitching. „The nature and diagnosis of foot-and-mouth disease“. Clinical Microbiology Newsletter 25, Nr. 11 (Juni 2003): 81–88. http://dx.doi.org/10.1016/s0196-4399(03)80014-4.

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Belák, S. „The molecular diagnosis of porcine viral diseases: A review“. Acta Veterinaria Hungarica 53, Nr. 1 (01.01.2005): 113–24. http://dx.doi.org/10.1556/avet.53.2005.1.11.

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The worldwide occurrence and re-occurrence of transboundary diseases like foot-and-mouth disease or classical swine fever indicates that there is a high need for the development of powerful, robust and high-capacity new diagnostic methods, which are able to detect the causative agents before they could spread to large populations and cause tremendous losses. This article reports the experiences of a research group on the development of molecular methods for the improved diagnosis of a range of porcine viral diseases, including diseases on List A of the Office International des Epizooties (OIE). Nucleic acid hybridisation and various polymerase chain reaction (PCR) assays have been applied for routine diagnosis of a large range of viral diseases. During the last one-and-a-half decade more than 40 nested PCR assays have been developed to detect a variety of DNA and RNA viruses. False positive and negative results are avoided by the use of special tools, practices and internal controls of amplification (mimics). Recently, real-time PCR methods (TaqMan, molecular beacons, Primer-Probe Energy Transfer system) have been developed for the diagnosis of a wide range of diseases, such as foot-and-mouth disease, swine vesicular disease and vesicular stomatitis. Multiplex PCR packages have been developed for the simultaneous detection of eight important viruses of swine. By introducing nucleic acid extraction and pipetting robotics, together with the multi-channel real-time PCR machines, the diagnostic procedures have become rapid, robust and automated. In order to standardise the real-time PCR assays, the rules of OIE are considered. By following the five steps of OIE standardisation and validation, the new diagnostic procedures are nationally and internationally standardised and harmonised. The rapid, powerful and internationally standardised molecular diagnosis contributes to the reduction of losses caused by the transboundary viral diseases in swine populations.

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Rémond, Michelle, Claude Kaiser und Françoise Lebreton. „Diagnosis and screening of foot-and-mouth disease“. Comparative Immunology, Microbiology and Infectious Diseases 25, Nr. 5-6 (Oktober 2002): 309–20. http://dx.doi.org/10.1016/s0147-9571(02)00028-0.

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Teo, Fiona Mei Shan, und Justin Jang Hann Chu. „Diagnosis of human enteroviruses that cause hand, foot and mouth disease“. Expert Review of Anti-infective Therapy 14, Nr. 5 (18.04.2016): 443–45. http://dx.doi.org/10.1586/14787210.2016.1173543.

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Nóbrega, Luciana Eloísa Da Silva Castro, Viviane Alves De Oliveira, Patrícia Teixeira De Oliveira, Éricka Janine Dantas Da Silveira und Ana Myriam Costa De Medeiros. „Report of a rare case of hand-foot-mouth disease in a adult woman with systemic arthritis“. Brazilian Dental Science 19, Nr. 4 (14.12.2016): 125. http://dx.doi.org/10.14295/bds.2016.v19i4.1261.

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Hand-foot-mouth disease (HFMD) is a highly infectious disease, rare in adults which usually presents a painfull stomatitis. We describe a rare case of HFMD in a 34-year-old woman with medical history of recent intestinal infection and systemic arthritis with only oral and hands involvement. Additionally, we discuss diagnosis and treatment of this disease and reinforce the importance of the correct diagnosis because delayed diagnosis can cause spread of the disease.Keywords: Adult; Arthritis; Mouth diseases.

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Kryazhinova, Irina Alekseevna, V. I. Ismailova, A. N. Kalinina und I. S. Lashko. „THE RESULTS OF THE SURVEY OF DENTISTS FOR THE CHALLENGES OF MALIGNANCIES“. Russian Journal of Dentistry 22, Nr. 6 (15.12.2018): 305–8. http://dx.doi.org/10.18821/1728-2802-2018-22-6-305-308.

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In connection with the deterioration of the environmental situation, the prevalence of bad habits, untimely access to the dentist for the treatment of dental diseases and preventive examinations, the complexity of diagnosis and treatment of precancerous diseases of the oral cavity cancer incidence with the localization of the tumor in the maxillofacial region increases. It is necessary to activate the early diagnosis of cancer at the dental reception and the qualification of dentists of all specialties in matters of cancer alertness. A survey of 176 dentists in 12 districts of the Moscow region on 10 issues, reflecting the frequency of detection of cancer pathology and precancerous conditions, doctors ‘ knowledge of diagnostic methods and therapeutic tactics in the detection of this pathology. Most of the interviewed dentists of the Moscow region consider the full collection of anamnesis and examination of the maxillofacial area and oral cavity in patients. Not more than 10% of dentists (mainly surgeons) reported about the treatment of patients with cancer (precancerous and cancerous diseases), at the same time about 80% of doctors met in their work with cancer. The main diagnoses of cancer pathology doctors note cancer of the mucous membrane of the mouth, tongue and lip; then leukoplakia and lichen planus. More than 40% of dentists do not use clinical and laboratory methods for the diagnosis of diseases of the mucous membrane of the mouth and lips; the most common methods of diagnosis of diseases of the mucous is Cytology and clinical examination. About 80% of dentists in the Moscow region had experience in referral for further examination and treatment of patients with cancer pathology in approximately equal proportion to dentists, surgeons, oncologists in the area and in MONICA (less often MOS); dentists in a number of districts of the Moscow region do not use the opportunities of regional dental institutions. Half of dentists do not fill in the reporting and regulatory documentation in the detection of cancer of the mouth. With a high readiness of more than 85% of dentists to use a new method of diagnosing cancer, about 40% of doctors were not familiar with the photodynamic screening test Vizi Lite Plus. The vast majority of dentists in the Moscow region consider it appropriate for the early diagnosis of cancer pathology organization of dental examination, dental preventive examinations, as well as the use of screening tests, although a third of doctors did not give proposals to improve the early diagnosis of cancer. There is no doubt that there is a need to improve the organizational and diagnostic base of early diagnosis of cancer in dentistry.

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Macovei, Luana Andreea, V. Cristescu, Mihaela Debita und C. A. Dinu. „Oral Manifestations of Osteoarticular Diseases“. Revista de Chimie 68, Nr. 10 (15.11.2017): 2440–42. http://dx.doi.org/10.37358/rc.17.10.5901.

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Human body acts as a whole and this leads to an increased occurrence of oral manifestations during the onset and development of systemic diseases. Therefore, oral pathological manifestations play an important role in the diagnosis, prognosis and treatment of diseases with osteoarticular involvement. General pathology has a strong impact on oral health which in turn is influenced by systemic factors. Oral manifestations can be used for making an early diagnosis of a serious condition that can be cured with appropriate therapy. Oral lesions can be explained by pathological processes and correlated with systemic diseases. When oral symptoms and signs are present, the disease is already in an advanced stage, due to the fact that the oral cavity is usually affected by a generalized disease. The mouth is part of the digestive system, but it has various symptoms caused by diseases located in other regions. 98 patients with oral manifestations of diseases with osteoarticular involvement were followed up in a private dental clinic from Iasi over a period of 3 years between June 2013 and July 2016. 47 patients were male (47.95%) and 51 were female (52.05%), aged between 18 and 65 years old, with a peak incidence between the ages of 45 and 60. The complex structure of the oral cavity was thoroughly explored (lips, lip mucosa, the corners of the mouth, gingival labial sulcus, oral vestibule, the internal face of the cheeks, the outer surface of gums, the floor and the ceiling of the oral cavity or the hard and the soft palate). The health status of the body is reflected by the health of the oral mucosa, which can be seen as a marker of various systemic diseases.

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Gudata, Daba. „Review on Foot and Mouth Disease“. International Journal of Research in Informative Science Application & Techniques (IJRISAT) 3, Nr. 4 (10.04.2019): 20–38. http://dx.doi.org/10.46828/ijrisat.v3i4.80.

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Ethiopia is a leading country in the number of livestock population in the African content and Livestock play a great role in the country economy. However, our country is not using from her livestock as much expected due to many animal diseases circulating in animal population. Therefore, the objective of this paper is to review on Foot and mouth disease. Foot and mouth disease (FMD) is one of the animal diseases which cause threat to our livestock; an acute systemic infection affecting cloven hoofed animal species. The main route of infection of ruminants such as cattle is the inhalation of airborne virus, but infection via alimentary tract or skin lesions is also possible. Some of the clinical symptoms of FMD include fever, anorexia, weight loss, lameness, salivation and vesicular lesions (mouth and skin). Larger host range always supports fast spread of disease with more chance of the antigenic diversity and hence makes the control programme a tedious task. Diagnosis of FMD is by Clinical signs, and in a laboratory by virus isolation, demonstration of the FMD viral antigens or nucleic acid in a sample tissue or fluid. To control FMD effectively, there is need of good infrastructure, trained veterinary staff, well equipped laboratories, good governance, rapid and accurate diagnostics, rapid response measures, continuous monitoring and surveillance, and compulsory vaccination.

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Fathi, Anahita, und Stefan Schmiedel. „Hand, Foot, and Mouth Disease as Differential Diagnosis of Monkeypox, Germany, August 2022“. Emerging Infectious Diseases 28, Nr. 12 (Dezember 2022): 2586. http://dx.doi.org/10.3201/eid2812.221487.

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Ali, Sarah, und Jane Setterfield. „Update on the clinical features, pathogenesis and investigation of autoimmune bullous disorders“. Faculty Dental Journal 4, Nr. 4 (Oktober 2013): 178–85. http://dx.doi.org/10.1308/204268513x13776914744790.

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The autoimmune bullous diseases are well known to dentists as skin diseases that occasionally affect the mouth and some can result in severe consequences such as blindness. This update summarises the clinical features and main therapeutic approaches, then focuses on the pathogenesis of these disorders and the laboratory methods used for diagnosis and management.

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Bradić-Vasić, Marija, Ana Pejčić, Milena Kostić, Ivan Minić, Radmila Obradović und Ivana Stanković. „Lichen planus: Oral manifestations, differential diagnosis and treatment“. Acta stomatologica Naissi 36, Nr. 81 (2020): 1980–94. http://dx.doi.org/10.5937/asn2081980b.

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Introduction: Some of the typical skin diseases, such as Pemphigus vulgaris, Pemphigoid mucosae oris, Erythema exudativum multiforme, Sclerodremia, Dermatitis herpetiformis-Duhring and Lichen planus, can cause swelling and irritation in mucous membranes of the oral cavity. Aim: The aim of the study was to precise diagnosis and treatment of oral Lichen planus manifestations. Methods: Analyzing the literature data and the experience of clinicians, the most common oral lichen planus manifestations were investigated. Results: This disease most commonly occurs in middle-aged patients (30-60 years) and is more common in women than in men. Oral Lichen planus is rarely seen in children. The disease presents in 0.5% to 2% of the population. Clinical history established the relation between oral Lichen planus and oral carcinoma, and therefore this disease should be considered a precancerous lesion. Conclusion: Dermatoses in the mouth are localized most often in the oral mucosa, both at the height of the occlusal line and in the mucous membrane of the retromolar area, but they can also occur in the mucous membranes of the tongue, the floor of the mouth and lips.

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Valle, Antonio Carlos F. do, Luiz Carlos Moreira, Rodrigo Almeida-Paes, João S. Moreira, Cláudia V. Pizzini, Mauro de Medeiros Muniz und Rosely M. Zancopé-Oliveira. „Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report“. Revista do Instituto de Medicina Tropical de São Paulo 48, Nr. 2 (April 2006): 113–16. http://dx.doi.org/10.1590/s0036-46652006000200012.

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We report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.

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Nazaryan, R. S., Yu V. Fomenko, N. A. Scheblykina, T. A. Kolesova, N. V. Golik und E. V. Sukhostavets. „Hand-Foot-and-Mouth Disease as a Manifestation of Enterovirus Infection“. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, Nr. 6 (25.12.2021): 207–12. http://dx.doi.org/10.26693/jmbs06.06.207.

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Lesions of the oral mucosa may be a sign of systemic human diseases. Most of manifested in the oral cavity diseases are benign, but it is necessary to differentiate them from more serious diseases. Dentists should know the manifestations and recent advances in the diagnosis and treatment of oral diseases, among which are viral infections, especially highly contagious, which include hand-foot-and-mouth disease. In order to prevent its spread and to identify in time possible complications, dentist should have deep knowledge about it. Hand-foot-and-mouth disease is a highly contagious viral infectious disease caused by various enteroviruses. Viruses of the genus Enterovirus are RNA genomic. It is necessary to know the main stages of the reproduction of RNA genomic viruses in the human body. 1. Adsorption on a cell (adhesion) – an interaction between specific receptors of virions and surface molecules of sensitive cells. 2. Penetration into the cell and "undressing" can be carried out in two ways: endocytosis and translocation. 3. The synthesis of viral particles of RNA-viruses (translation) – as a result specific proteins for viral replication are synthesized. 4. Complete assembly of RNA-viruses. 5. Release of daughter virions from the cell. The source of infection can be both a sick person and a virus carrier. Asymptomatic carriage can last for weeks, sometimes months. The most intense pathogen is released in the first days of the disease. The predominant morbidity of children speaks about the high natural susceptibility of a human. For diseases, which are caused by enteroviruses, polymorphism of clinical manifestations is specific. In most cases, the violation of the general condition is insignificant and the course of the disease is benign. The initial phase is usually followed by enanthema and erythematous, papular or vesicular lesions of the skin, localized mainly on the palms and soles, as well as vesicles in the oral cavity. Enanthema usually precedes the appearance of a skin rash. Oral lesions may occur without skin symptoms. Diagnosis of enteroviral vesicular stomatitis is based on anamnestic and clinical data. There are many diagnostic tests available, but PCR of throat and vesicular fluid swabs, if available, is one of the most effective. After an illness, in most cases, immunity is formed, the possibility of developing cross-immunity to other types of the virus is not excluded

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Zalmi, Wahyuni Fithratul. „Sistem Pakar Pendeteksi Penyakit Gigi Dan Mulut Dengan Menggunakan Metode Forward Chaining“. INFORMATIKA 11, Nr. 1 (31.01.2023): 43–53. http://dx.doi.org/10.36987/informatika.v11i1.3846.

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Diseases of the teeth and mouth are one of the many health problems that often interfere with the activities of sufferers. Diseases attack indiscriminately Reed both children and adults. Dental and oral health is an important thing that needs to be considered. Problems that occur in the teeth and mouth must be handled properly so as not to cause other problems that occur due to improper handling. Doctors are required to provide decisions quickly, and accurately in diagnosing diseases suffered by their patients. But to make such a diagnosis is not easy, considering that each disease has more than one symptom, and several different diseases have almost the same symptoms. Decision - making in diagnosing the disease carefully and appropriately must be done quickly for the treatment process of the disease. Especially for young doctors and all doctors if they find cases that are difficult to diagnose, they will generally be guided by books. This will certainly take time and effort. Treatment for this problem is to build an expert system application that functions to diagnose diseases of the teeth and mouth. This expert system application is expected to help doctors in deciding to diagnose diseases quickly or become a matter of consideration or reference.

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Л.Н., Казарина, Гордецов А.С., Красникова О.В., Белозеров А.Е. und Пурсанова А.Е. „DIAGNOSIS OF PRECANCEROUS DISEASES OF THE MUCOUS MEMBRANE OF THE MOUTH BY THE METHOD OF INFRARED SPECTROSCOPY“. "Medical & pharmaceutical journal "Pulse" 21, Nr. 12 (30.12.2019): 77–82. http://dx.doi.org/10.26787/nydha-2686-6838-2019-21-12-77-82.

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Sharma, D., A. Mckendry, S. Nageshwaran und J. Cartledge. „A case of oral ulceration and disseminated histoplasmosis in HIV infection“. International Journal of STD & AIDS 23, Nr. 7 (Juli 2012): 522–23. http://dx.doi.org/10.1258/ijsa.2011.011261.

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A 51-year-old Malawian woman presented with persistent mouth ulceration and an eight-month history of non-specific respiratory symptoms. Histoplasma capsulatum was diagnosed on gum, gastric and lymph node biopsies. Identification of H. capsulatum prompted HIV testing and the patient tested positive with a CD4 count of 40 cells/mm3. The diagnosis of histoplasmosis was delayed due to its unusual presentation.

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Malik, Jayraj, Vaishali Keluskar und Sulem Ansari. „Expanding the Role of Oral Physician in Early Diagnosis of Commonly Occurring Systemic Diseases“. International Journal of Health Sciences and Research 12, Nr. 12 (22.12.2022): 132–35. http://dx.doi.org/10.52403/ijhsr.20221222.

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Dentistry deals with the identification, mitigation, and prevention of diseases of teeth, gums, mouth, and jaw. Dentistry can have an effect on your overall health and for treating patients with chronic diseases and other conditions safely and effectively, dentists need to have a solid knowledge of basic clinical medicine. Dentists should possess the same level of knowledge as physicians in all other branches of medicine due to changes in life expectancy and lifestyles, as well as the rapid advancement of biomedical sciences and help in diagnosing systemic diseases based on oral findings. The present review throws a spotlight on these activities and also suggests some of the measures that can be adopted to modify dental education to turn dentists into oral physicians by early diagnosing of systemic diseases. Key words: Dentistry, disease, education, physician, primary care

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Tanık, Abdulsamet, und Mehmet Gül. „The validity of the Community Periodontal Index of Treatment Needs (CPITN) in epidemiological studies of periodontal diseases“. International Dental Research 10, Nr. 2 (31.08.2020): 44–48. http://dx.doi.org/10.5577/intdentres.2020.vol10.no2.3.

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Objectives: The aim of this study was to evaluate the validity of partial CPITN (PCPITN) and full-mouth CPITN (FCPITN) indexes from CPITN index versions used in the diagnosis of periodontal disease. Method: The study included 1,000 patients over the age of 20. The clinical attachment loss examination and clinically assisted full-mouth periodontal examination (gold standard) including the depth of the periodontal pocket on probing and dental stones were performed. PCPITN and FCPITN index versions were compared with the gold standard oral examination. Sensitivity, specificity and diagnostic estimation tables were statistically created from the obtained data. Results: For Gingivitis, the sensitivity of the PCPITN index was found to be 68.88%, specificity was 85.94% and the field value under the Receiver Operating Characteristic (ROC) curve was 0.6893. For periodontitis, FCPITN index sensitivity was 89.28%, specificity was 96.56% and field value under the ROC curve was 0.931. Conclusion: Although FCPITN and PCPITN indexes have a near moderate value in the diagnosis of gingivitis, they were found to be more effective in the diagnosis of periodontitis. We think that the FCPITN index is particularly effective in the diagnosis of periodontitis. How to cite this article: Tanık A, Gül M. The validity of the Community Periodontal Index of Treatment Needs (CPITN) in Epidemiological Studies of Periodontal Diseases. Int Dent Res 2020;10(2):44-48. https://doi.org/10.5577/intdentres.2020.vol10.no2.3 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Scala, A., L. Checchi, M. Montevecchi, I. Marini und M. A. Giamberardino. „Update on Burning Mouth Syndrome: Overview and Patient Management“. Critical Reviews in Oral Biology & Medicine 14, Nr. 4 (Juli 2003): 275–91. http://dx.doi.org/10.1177/154411130301400405.

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Burning Mouth Syndrome (BMS) is a chronic pain syndrome that mainly affects middle-aged/old women with hormonal changes or psychological disorders. This condition is probably of multifactorial origin, often idiopathic, and its etiopathogenesis remains largely enigmatic. The present paper discusses several aspects of BMS, updates current knowledge, and provides guidelines for patient management. There is no consensus on the diagnosis and classification of BMS. The etiopathogenesis seems to be complex and in a large number of patients probably involves interactions among local, systemic, and/or psychogenic factors. In the remaining cases, new interesting associations have recently emerged between BMS and either peripheral nerve damage or dopaminergic system disorders, emphasizing the neuropathic background in BMS. Based on these recent data, we have introduced the concepts of “primary” (idiopathic) and “secondary” (resulting from identified precipitating factors) BMS, since this allows for a more systematic approach to patient management. The latter starts with a differential diagnosis based on the exclusion of both other orofacial chronic pain conditions and painful oral diseases exhibiting muco-sal lesions. However, the occurrence of overlapping/overwhelming oral mucosal pathologies, such as infections, may cause difficulties in the diagnosis ("complicated BMS"). BMS treatment is still unsatisfactory, and there is no definitive cure. As a result, a multidisciplinary approach is required to bring the condition under better control. Importantly, BMS patients should be offered regular follow-up during the symptomatic periods and psychological support for alleviating the psychogenic component of the pain. More research is necessary to confirm the association between BMS and systemic disorders, as well as to investigate possible pathogenic mechanisms involving potential nerve damage. If this goal is to be achieved, a uniform definition of BMS and strict criteria for its classification are mandatory.

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Abreu-Velez, Ana Maria, Bruce R. Smoller und Michael S. Howard. „An extraordinary case of oral leukocytoclastic vasculitis demonstrating igd deposition around dermal vessels and within mucosal keratinocytes“. Our Dermatology Online 12, Nr. 1 (02.01.2021): 50–53. http://dx.doi.org/10.7241/ourd.20211.13.

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Cutaneous vasculitides include a widespread and heterogeneous cluster of diseases affecting the blood vessels that are clinically characterized by polymorphic skin lesions, including palpable purpura, urticarial and/or necrotic-ulcerative lesions. Often, they can be manifestations of a systemic disease. Selected cases occur in the mouth. A 75-year-old female presented to her physician for the sudden appearance of blisters in her mouth, with severe orodynia and no history of other diseases or medication intake. A skin biopsy of the oral mucosa yielded a diagnosis of leukocytoclastic vasculitis. The direct immunofluorescence and immunohistochemistry stains demonstrated deposits of IgD, IgG, IgA, IgM, kappa, lambda, C1q, C3c, albumin and fibrinogen at the upper dermal neurovascular plexus. IgD also demonstrated positive nucleolar staining of the keratinocytes. Our case involves a rare presentation of oral cutaneous vasculitis with immune deposits of several immunoglobulins, complement, albumin and fibrinogen. Our case adds importance to studies of the IgD role in antigenic complex immune responses, especially in the mouth.

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Nasibullin, G. G., und S. A. Zizevskiy. „Diagnosis and treatment of dysfunctions of the temporomandibular joint“. Kazan medical journal 76, Nr. 2 (15.03.1995): 137–40. http://dx.doi.org/10.17816/kazmj97148.

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Diseases of the temporomandibular joint (TMJ) with functional disorders occupy a special place in the practice of orthopedic dentistry due to the complex clinic, morphology and function. Unlike other joints, the TMJ is devoid of the hyaline cover of the articular surfaces. The free capsule and the presence of ligaments allow the heads to perform various movements on different floors of the joint divided by the meniscus: sliding-translational in the upper section and articulated in the lower section. With some physiological movements, for example, when the mouth is opened wide, the articular heads come out of the articular fossae, resembling a dislocation on radiographs, which is actually a physiological subluxation.

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Chen, Yu, Bowen Dai, Shujie Han, Guangcai Duan, Haiyan Yang, Shuaiyin Chen, Wangquan Ji und Yuefei Jin. „Arising Concerns of Atypical Manifestations in Patients with Hand, Foot, and Mouth Disease“. Vaccines 11, Nr. 2 (10.02.2023): 405. http://dx.doi.org/10.3390/vaccines11020405.

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Hand, foot, and mouth disease (HFMD) is a mild exanthematous, febrile disease, but it also remains a threat to global public health. HFMD is characterized by a brief febrile illness in children and with a typical skin rash of the hand and foot, with or without mouth ulcers. However, the morphology and distribution of vesicles, as well as accompanying symptoms, are varied among atypical HFMD. An upsurge in atypical presentations of HFMD caused by Coxsackievirus A6 (CVA6), including Gianotti–Crosti-like eruptions, eczema coxsackium, petechial/purpuric eruption, and vesiculobullous exanthema, can be difficult to diagnose clinically as it may mimic other severe skin diseases, such as eczema herpeticum, varicella, disseminated zoster, and erythema multiforme major. The recognition of the distinguishing features of atypical HFMD is vital for an accurate and timely diagnosis, as is initiating appropriate laboratory evaluation and supportive care. Clinicians must identify the wide range of cutaneous and mucosal alterations caused by atypical HFMD. A systemic, high-quality overview of atypical HFMD is needed for advances in better strategies for clinical diagnosis and treatment. Hence, this review is aimed at summarizing the available data on clinical investigations and differential diagnostics to provide a scientific guide for the timely diagnosis of HFMD for preventing serious complications.

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Wieczorek, Magdalena, Agnieszka Ciąćka, Arleta Krzysztoszek, Agnieszka Figas und Leszek Szenborn. „Genetic Characterization of Human Enteroviruses Associated with Hand, Foot and Mouth Diseases in Poland, 2013–2016“. Polish Journal of Microbiology 66, Nr. 3 (27.09.2017): 405–9. http://dx.doi.org/10.5604/01.3001.0010.4889.

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The objective of the present study was to describe the molecular characteristics of enteroviruses associated with hand, food, and mouth disease (HFMD) in Poland. Clinical material from HFMD cases, that occurred during 2013–2016 were examined. It has been showed that coxsackievirus A6 (CVA6), CVA10 and CVA16 were circulating in the country. Phylogenetic analysis showed that Polish CVA6 strains were divided into two distinct clusters suggesting two independent introductions. This is the first report of CVA6 infections associated with HFMD in Poland. These results emphasize the need for continuous monitoring of HFMD and facilitation of the diagnosis using molecular approaches.

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Singh, Himanshu, Vedant Patel, Rahul A. Razdan, Resham Maheshwari, Sourabh Sharma und Divya Jain. „Knowledge of Systemic Diseases Presenting the Oral Signs and Symptoms: A Short Review“. Dental Journal of Advance Studies 07, Nr. 02 (August 2019): 056–60. http://dx.doi.org/10.1055/s-0039-1698361.

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AbstractThe accurate examination of oral cavity may acknowledge findings that demonstrate the presence of underlying systemic, which helps in earlier diagnosis as well as treatment. The oral tissues are accountable to damage as a disease consequence that primarily affects other body systems. Various systemic diseases show oral manifestation. Some of these oral conditions include oral ulcers, caries, dry mouth, gingival bleeding, and gingival hypertrophy. This review article is prepared to make general physicians as well as dentist aware about systemic disorders or conditions that show dental or oral manifestation.

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Mauliza, Mauliza, Mutammimul Ula, Ilham Saputra, Rosya Afdelina und Muhammad Ikhsan. „Application of Expert System With Forward Chaining Method in Detecting Infectious Diseases in Children“. Science Midwifery 10, Nr. 4 (26.09.2022): 2777–85. http://dx.doi.org/10.35335/midwifery.v10i4.714.

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Limited information about infectious diseases, especially diseases in children, is a major problem. The application of an expert system in detecting infectious diseases in children is needed in early detection in diagnosing diseases. The purpose of this study was to determine the diagnosis of infectious diseases in children based on the symptoms of the disease and the results of the diagnosis from the system for recommendations to patients with the type of disease suffered and the solutions provided. The stages of the research are collecting data and information on infectious diseases in children. The second is symptom and rule data collection. The third is making each solution from the types of diseases, and the last step is the solution for preventing infectious diseases in children, which is displayed in the system based on the analysis of disease rules. As for the variables in the application of disease tracing graphs, there are 17 rule graphs in detecting diseases in children. Analysis of the rules in the forward chaining method in disease detection for the types of symptoms of high fever (G001), sore throat and cough (G004), persistent hard cough that begins with a long breath through the mouth (G023), and diarrhea (defecation). watery more than three times per day (G030) Itching (G48), irritable and irritable (G033) The upper right abdominal area will feel pain, especially when pressed (G49). Analysis of each symptom G001, G004, G023, G030, G031, G033, G48, G49, the disease that will be detected is P009, namely Hepatitis A. The results obtained are in accordance with patient input by conducting a search using a rule model that utilizes a trace tree. forward based on tracing pediatric disease diagnoses with existing facts. The results of this study can display the results of diagnosis, disease analysis, solutions, and prevention based on the symptoms of the disease in children.

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Lin, Jingli, Changwei Li, Xi Lan und Jinge Li. „A Pipeline-based Low Complexity Dual Thresholds and Multiresolution Mouth Detection Method“. Journal of Physics: Conference Series 2218, Nr. 1 (01.03.2022): 012016. http://dx.doi.org/10.1088/1742-6596/2218/1/012016.

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Abstract Mouth detection is a basic step in the automatic diagnosis of buccal diseases. This paper proposes a method of using FPGA(Field Prog ram mable Gate Array) to detect the human mouth region in images, which adopts a pipelined design for high-speed operating. Thus, it can be applied to mouth motion detection as well. After an original image is processed regularly by median filtering, color conversion is performed to obtain its corresponding H component, which is used to create a partitioned binary image. Each constituent region of the binary image uses two thresholds for regional processing separately, which results in two binary images: one comprises the mouth and some other regions with a color close to that of the mouth, and the other indicates the position of the mouth. A logical AND is performed on these two binary images to calculate the border of mouth region with reduced resolution, which is then superimposed on the buffered original image to confirm the mouth region eventually. An FPGA-based scheme is presented, which shows the method could detect the whole mouth properly, with a maximum clock speed of 150MHz. In addition, processing an image of 200*200 only consumes 2178 Slice LUTs(Look Up Table), which is a relatively low resource consumption.

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Djuran, Boris, Zoran Tatic, Neda Perunovic, Natasa Pejcic, Jovana Vukovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic und Mia Rakic. „Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study“. International Journal of Environmental Research and Public Health 20, Nr. 1 (28.12.2022): 477. http://dx.doi.org/10.3390/ijerph20010477.

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Peri-implant diseases are an emerging public health problem, and it is considered a limitation of standard diagnostics. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies.

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SCHULZ, Maykon Kennedy, Mariel Ruivo BIANCARDI, Darcy FERNANDES, Luciana Yamamoto de ALMEIDA, Andreia BUFALINO und Jorge Esquiche LEON. „Glycogenic acanthosis on mouth clinically present as white plaque“. RGO - Revista Gaúcha de Odontologia 66, Nr. 3 (September 2018): 274–77. http://dx.doi.org/10.1590/1981-8637201800030000133422.

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ABSTRACT Glycogenic acanthosis is a benign condition, commonly observed during endoscopic procedures in older patients, which present as slightly elevated whitish plaques often on the lower third of the oesophagus. Microscopically, glycogenic acanthosis is composed of hyperplastic squamous epithelium with intracytoplasmic glycogen deposits. The extraoesophageal glycogenic acanthosis is extremely rare, with only three case reports in the English-language literature. We report a white lesion showing glycogenic acanthosis-like features located on the left posterolateral border of the tongue, affecting a 56-year-old male patient. The medical history was non-contributory and the patient did not show any lesions during endoscopic examination of the oesophagus, stomach, and upper duodenum. Glycogenic acanthosis is a benign condition, which should be included in the differential diagnosis when assessing oral white lesions. It is important also to recognize this benign condition early and rule out the possibility of other more severe diseases, but further studies were necessary for better define their potential for persistence or recurrence, as observed in the current case.

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Borozentseva, Vita A., Vladislav Yu Borozentsev, Irina P. Pochitaeva, Olga A. Rozhdestvenskaya und Tamara V. Evdokimova. „Senile mouth as a component of geriatric status“. RESEARCH RESULTS IN BIOMEDICINE 7, Nr. 3 (30.09.2021): 296–307. http://dx.doi.org/10.18413/2658-6533-2021-7-3-0-8.

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According to the literature, there is a high prevalence of the syndrome of senile asthenia (frailty) among the elderly. This condition is associated with a number of physical, functional and biochemical changes in the body. The interrelationships of the senile mouth with the malnutrition syndrome are known, the associations with other geriatric syndromes are insufficiently studied. At the same time, early diagnosis of conditions and diseases as the risk factors for the development of senile mouth is very important. The aim of the study: To study the role of the senile mouth in the formation of geriatric status. Materials and methods: In total, 570 elderly and senile people were included in the study (58 persons without adentia, 512 persons with adentia. The age of the patients ranged from 65 to 84 years. The groups of patients without adentia and with adentia were comparable in age and sex composition. Results: The study showed that the senile mouth is associated with the loss of 11 or more teeth in any variant of adentia, and with a smaller number of lost teeth – with the 1st and 4th classes of adentia according to E. Kennedy, while the ethiological causes of adentia do not have a significance in increasing the risk for developing of senile mouth. Cardiovascular pathology, type 2 diabetes mellitus and diseases of the musculoskeletal system increase the risk of developing the progression of the senile mouth. The senile mouth is associated with such geriatric syndromes as the syndrome of malnutrition and the risk of its development, dina/ sarcopenia, falls syndrome, depression, cognitive disorders and uncorrected sensory deficits. Conclusion: Senile mouth take place in the processes of formation of geriatric status in elderly patients. It is necessary to investigate the state of the dentition according to E. Kennedy. The patients with complete adentia, as well as with grades 1, 4 of adentia and its mixed forms are the groups of increased risk of frailty. It is also advisable to conduct a comprehensive geriatric assessment with targeted correction of the identified geriatric syndromes in people with senile mouth before and after dental intervention.

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Kosyuga, S. U., und S. E. Varvanina. „ANALYSIS OF MODERN METHODS OF DIAGNOSIS IN DISEASES OF THE MUCOUS MEMBRANE OF THE MOUTH, ASSOCIATED WITH HELICOBACTER PYLORI“. Journal of scientific articles "Health and Education millennium" 19, Nr. 4 (30.04.2017): 30–33. http://dx.doi.org/10.26787/nydha-2226-7425-2017-19-4-30-33.

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Sellers, R. F. „John Burns Brooksby. 25 December 1914 — 17 December 1998“. Biographical Memoirs of Fellows of the Royal Society 53 (Januar 2007): 77–92. http://dx.doi.org/10.1098/rsbm.2007.0002.

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John Brooksby was an outstanding veterinary virologist, who worked at the Animal Virus Diseases Research Institute, Pirbright, for 40 years, for 16 of which he was Director of the Institute. He will be remembered for his contributions to the diagnosis of foot-and-mouth disease, for his discovery of four new types, for the classification of subtypes and for fundamental studies of the virus. As Deputy Director and Director he was responsible for programmes on fundamental investigations of foot–and–mouth disease virus and other viruses exotic to the UK and for the application of the results both in the UK and worldwide. His advice on the distribution and the control of foot–and–mouth disease was sought by international organizations and by individual countries and was responsible for reducing the risk of spread of disease.

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Longjam, Neeta, Rajib Deb, A. K. Sarmah, Tilling Tayo, V. B. Awachat und V. K. Saxena. „A Brief Review on Diagnosis of Foot-and-Mouth Disease of Livestock: Conventional to Molecular Tools“. Veterinary Medicine International 2011 (2011): 1–17. http://dx.doi.org/10.4061/2011/905768.

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Foot-and-mouth disease (FMD) is one of the highly contagious diseases of domestic animals. Effective control of this disease needs sensitive, specific, and quick diagnostic tools at each tier of control strategy. In this paper we have outlined various diagnostic approaches from old to new generation in a nutshell. Presently FMD diagnosis is being carried out using techniques such as Virus Isolation (VI), Sandwich-ELISA (S-ELISA), Liquid-Phase Blocking ELISA (LPBE), Multiplex-PCR (m-PCR), and indirect ELISA (DIVA), and real time-PCR can be used for detection of antibody against nonstructural proteins. Nucleotide sequencing for serotyping, microarray as well as recombinant antigen-based detection, biosensor, phage display, and nucleic-acid-based diagnostic are on the way for rapid and specific detection of FMDV. Various pen side tests, namely, lateral flow, RT-LAMP, Immunostrip tests, and so forth. are also developed for detection of the virus in field condition.

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MOU, J., M. DAWES, Y. LI, Y. HE, H. MA, X. XIE, S. GRIFFITHS und J. CHENG. „Severe hand, foot and mouth disease in Shenzhen, South China: what matters most?“ Epidemiology and Infection 142, Nr. 4 (01.07.2013): 776–88. http://dx.doi.org/10.1017/s0950268813001453.

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SUMMARYCase report data and a matched case-control study were used to investigate the epidemiological characteristics of hand, foot and mouth disease (HFMD) in children in Shenzhen, China between 2008 and 2011. Multivariate analyses were used to evaluate factors associated with severity of infection. Laboratory tests were performed to determine aetiological identification for samples from 163 severe and fatal cases as well as an outpatient-based HFMD sentinel surveillance system (n = 446). All identified EV71 belonged to sub-genotype C4a. No major changes in the CA16 and EV71 viruses were found until the end of 2011. Annual attack rates and the case-severity ratios (CSRs) rose from 0·82/1000 and 0·56/1000, respectively, in 2008 to 2·12/1000 and 6·13/1000 in 2011. The CSR was higher in migrants than in local residents. The adjusted odds ratio (OR) of having a severe attack for being a migrant was 2·45, having a fever >39°C (OR 5·77), visiting a private clinic (OR 2·65), longer time from symptom onset to diagnosis (OR 1·49), visiting a doctor (OR 1·51), early use of intramuscular pyrazolone (OR 3·36), early use of intravenous glucocorticoids (OR 2·28), or the combination of both (OR 3·75). The mortality and increasing case severity appears to be associated with socioeconomic factors including migration and is of worldwide concern.

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Hermes, R., J. Saragusty, I. Moser, S. Holtze, J. Nieter, K. Sachse, T. Voracek et al. „Bronchoalveolar lavage for diagnosis of tuberculosis infection in elephants“. Epidemiology and Infection 146, Nr. 4 (05.02.2018): 481–88. http://dx.doi.org/10.1017/s0950268818000122.

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AbstractTuberculosis (TB) has been known to affect elephants for thousands of years. It was put into spotlight when few circus elephants were diagnosed carryingMycobacterium(M.)tuberculosis. Because of the zoonotic risk and high susceptibility toM. tuberculosis, periodic testing was enacted since, in captive breeding programmes. Presently, trunk wash is the recommended diagnostic procedure for TB. Trunk wash, however, puts the operator at risk, has low sensitivity, and is prone to contamination. Here, bronchoalveolar lavage is described for the first time for TB diagnosis in elephants. Bronchial, trunk and mouth fluids were investigated using bacterial culture,M. tuberculosiscomplex (MTC)-specific real-time quantitative PCR (qPCR) and mycobacterial genus-specific qPCR for overall presence of mycobacteria or mycobacterial DNA including bacteria or DNA of closely related genera, respectively, in 14 elephants. Neither bacteria of the MTC nor their DNA were identified in any of the elephants. Yet, 25% of the cultures grew non-tuberculous mycobacteria (NTM) or closely related bacterial species. Furthermore, 85% of the samples contained DNA of NTM or closely related bacterial genera. This finding might explain continued false-positive results from various serological tests. From a zoonotic point of view, bronchoalveolar lavage is safer for the testing personal, has higher probability of capturing MTC and, through PCR, identifies DNA NTM in elephants. Yet, necessary endoscopic equipment, animal sedation and access to a TB reference laboratory might pose challenging requirements in remote conditions in some elephant range countries.

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Pereira, Juliana Reuter, Andressa Bolognesi Bachesk, Ricardo Augusto Gonçalves Pierri und Liogi Iwaki Filho. „Myositis Ossificans Traumatica of the Temporal Muscle Treated by Bilateral Coronoidectomy and Aggressive Physiotherapy: A Case Report“. Craniomaxillofacial Trauma & Reconstruction Open 6 (01.01.2021): 247275122098603. http://dx.doi.org/10.1177/2472751220986033.

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Myositis Ossificans Traumatica (MOT) is a rare condition that affects soft tissues after a trauma and hardly affects the mastication muscles. The occurrence in the temporal muscle is uncommon, and trismus is the most prevalent symptom. The diagnosis of the pathology is sufficiently obtained through the collection of clinical history, physical and imaging exams. Differential diagnosis is important mainly to rule out more aggressive diseases, such as osteosarcoma. Treatment becomes more invasive as the ossification matures, and resection of structures adjacent to the tumor, such as coronoidectomy, is well indicated for promoting good results on the mouth opening amplitude. However, to maintain this amplitude, aggressive myofunctional therapy is required. Nevertheless, the literature has no well-defined protocol for this physiotherapy. Therefore, this article reports a rare case of MOT in the temporal muscle that was treated conservatively, with bilateral coronoidectomy and mouth opening physiotherapy, and obtained a satisfactory result. Consequently, it also presents a suggestion of a postoperative physiotherapy protocol.

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Farzinnia, Golnoush, Mehdi Sasannia, Shima Torabi, Fahimeh Rezazadeh, Alireza Ranjbaran und Azita Azad. „Correlation between Clinical and Histopathological Diagnoses in Oral Cavity Lesions: A 12-Year Retrospective Study“. International Journal of Dentistry 2022 (14.05.2022): 1–7. http://dx.doi.org/10.1155/2022/1016495.

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Objective. Proper diagnosis plays a key role in the treatment and prognosis of all diseases. Although histopathological diagnosis is still known as the gold standard, final diagnosis becomes difficult unless precise clinical descriptions are obtained. So, this study aimed to evaluate the concordance of the clinical and histopathological diagnoses of all oral and maxillofacial biopsy specimens in a 12-year duration. Materials and Methods. Archive files and clinical findings related to 3001 patients who had been referred to the Department of Oral Pathology during a 12-year period were reviewed. The recorded information in files included age, sex, lesion’s location, clinical and histopathological diagnoses, and specialty of dentists. Results. Out of 3001 cases included and reviewed in this study, 2167 cases (72.2%) were consistent between clinical and histopathologic diagnoses. Age, sex, and clinician’s specialty were indicated to have no significant effect on diagnosis (p values = 0.520, 0.310, 0.281, respectively), but location and type of lesion affected that (p values = 0.040 and 0.022, respectively). In regard to location, the highest concordance of clinical and histopathologic diagnoses was observed in mouth floor lesions, and the lowest one was in gingival mucosa. In terms of lesion category, the highest and the lowest concordance rates belonged to white and red lesions and pigmented lesions, respectively. Conclusion. The results of the present study show that the consistency of clinical and histopathological diagnoses was three times more than their inconsistency, and the accuracy of the clinicians was largely acceptable.

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Lutskaya, Irina K. „A systematic examination of the mucous membrane of the mouth (oral mucous membrane) – method of early diagnosis of precancerous diseases“. Clinical review for general practice 2, Nr. 2 (01.03.2021): 32–37. http://dx.doi.org/10.47407/kr2021.2.2.00040.

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The article presents information on the liability of the dentist for reducing the risk of development of pathological processes, including malignant neoplasms of the oral cavity. A thorough inspection of the oral mucous membrane, in accordance with WHO recommendations provides a systematic survey of all departments of the oral cavity and surrounding tissues. This tactic can significantly reduce the risk of development of pathological lesions of the oral cavity, to prevent malignant transformation or provide early diagnosis.

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Handayani, Leni, und Siswanto . „Diagnosa penyakit dan analisis kualitas air untuk kesehatan ikan Nila (Oreochromis niloticus) yang dipelihara pada keramba jaring apung“. e-Journal BUDIDAYA PERAIRAN 10, Nr. 2 (04.10.2021): 177. http://dx.doi.org/10.35800/bdp.10.2.2022.37638.

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The purpose of this study was to diagnose diseases that attack tilapia and analyze the quality of the waters around the floating net cages. The research was conducted using in situ and ex situ methods. Sampling was carried out in Pematang Limau Village, while for disease diagnosis at the PUSKESWAN Laboratory and water chemistry analysis at the Health and Calibration Laboratory of Palangka Raya. Diagnosis is made by taking fish samples and observing the clinical symptoms of fish. Disease diagnosis included parasitic and bacterial diseases. For water quality parameters, physical and chemical parameters of the waters were observed. Based on the diagnostic results of observations in the field and in the laboratory, a conclusion was obtained that the tilapia (Oreochromis niloticus) reared in floating net cages in Pematang Limau Village did not experience specific diseases because the symptoms showed only bleeding and lumps on the skin, side of the mouth of some fish only. Laboratory results from the identification of the disease for bacterial diseases were not found, only parasitic diseases with a mild attack level with 4 types of ectoparasites that often attack tilapia. The results of the analysis of water quality in the waters also showed relatively good, but when viewed from the BOD and COD values, it shows that there was light water pollution.

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Wang, Bin, Jingliang Li, Yang Wang, Na Du, Luyao Sun, Huimin Xiao, Ying Zhao, Wanguo Bao und Wenyan Zhang. „Understanding the epidemiological characteristics of EV71 and CVA16 infection to aid the diagnosis and treatment of hand, foot, and mouth disease“. Journal of Medical Virology 91, Nr. 2 (22.10.2018): 201–7. http://dx.doi.org/10.1002/jmv.25282.

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ALMEIDA, Regina Capanema de, und Roberto Pietra PEDROSO. „Nosocomial infection in long-term care facilities. A survey in a Brazilian psychiatric hospital“. Revista do Instituto de Medicina Tropical de São Paulo 41, Nr. 6 (November 1999): 365–70. http://dx.doi.org/10.1590/s0036-46651999000600006.

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Nosocomial infection among male patients in a public psychiatric hospital was studied and the definitions for use in long-term care facilities were employed for diagnosis. The overall nosocomial infection rate was 6.7 per 1,000 day inpatients; 55.6% of these infections were identified in the respiratory tract, 50% of them being respiratory viral diseases; 38.9% of the nosocomial infections involved the eyes, ears, nose, throat and mouth, and 5.6% involved the skin and soft tissues. The epidemiological characteristics and the main clinical alterations of these inpatients were also identified.

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Ciechanowska, Monika, und Jan Stachurski. „Differentiating stroke, transient ischemic attack, or hemiplegic migraine in a teenager: a case report“. Medical Science Pulse 15, Nr. 2 (29.07.2021): 1–5. http://dx.doi.org/10.5604/01.3001.0015.0631.

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Background: The symptoms of stroke in the pediatric population are less evaluated than in adults. Although certain indicators are characteristic of stroke – acute drooping of the mouth corners, hemiparesis, and headache – they are not pathognomonic. Other diseases may manifest with similar symptoms, such as the first episode of hemiplegic migraine, and should be differentiated from stroke at an emergency department. Aim of the study: We present the differential diagnosis between stroke, transient ischemic attack, and first episode of hemiplegic migraine in a teenager with alarming focal symptoms. Case report: We present a case of 15-year-old patient with acute headache, drooping of the right mouth corners, and hemiparesis of the right upper and lower limb. He was brought by ambulance to the emergency department under suspicion of a stroke. A series of diagnostic tests performed at the Emergency Department did not reveal any vascular incident. Further diagnosis was performed at the Neurology Department. The patient was discharged from the hospital with a suspicion of first attack of hemiplegic migraine or transient ischemic attack. Conclusions: Differentiating stroke from other conditions in young patients is a significant challenge. The stroke diagnostic process in children requires further research to support accurate diagnosis and, if necessary, treatment as rapidly as possible.

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Wang, Zhanwen, Yanping Zheng, Deqiang Zhao, Ziwei Zhao, Lixin Liu, Artem Pliss, Feiqi Zhu, Jun Liu, Junle Qu und Ping Luan. „Applications of fluorescence lifetime imaging in clinical medicine“. Journal of Innovative Optical Health Sciences 11, Nr. 01 (20.11.2017): 1830001. http://dx.doi.org/10.1142/s179354581830001x.

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Fluorescence lifetime is not only associated with the molecular structure of fluorophores, but also strongly depends on the environment around them, which allows fluorescence lifetime imaging microscopy (FLIM) to be used as a tool for precise measurement of the cell or tissue microenvironment. This review introduces the basic principle of fluorescence lifetime imaging technology and its application in clinical medicine, including research and diagnosis of diseases in skin, brain, eyes, mouth, bone, blood vessels and cavity organs, and drug evaluation. As a noninvasive, nontoxic and nonionizing radiation technique, FLIM demonstrates excellent performance with high sensitivity and specificity, which allows to determine precise position of the lesion and, thus, has good potential for application in biomedical research and clinical diagnosis.

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Jiang, Bingfu, Jianhua Zhang, Xianhui You, Chen Dong, Xianfeng Cheng, Xing Dai und Jihong Meng. „Diagnosis of hand, foot, and mouth disease caused by EV71 and other enteroviruses by a one-step, single tube, duplex RT-PCR“. Journal of Medical Virology 84, Nr. 11 (19.09.2012): 1803–8. http://dx.doi.org/10.1002/jmv.23391.

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Keck, Hanna, Benedikt Litz, Bernd Hoffmann, Julia Sehl-Ewert, Martin Beer und Michael Eschbaumer. „Full-Length Genomic RNA of Foot-and-Mouth Disease Virus Is Infectious for Cattle by Injection“. Viruses 14, Nr. 9 (30.08.2022): 1924. http://dx.doi.org/10.3390/v14091924.

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Safe sample transport is of great importance for infectious diseases diagnostics. Various treatments and buffers are used to inactivate pathogens in diagnostic samples. At the same time, adequate sample preservation, particularly of nucleic acids, is essential to allow an accurate laboratory diagnosis. For viruses with single-stranded RNA genomes of positive polarity, such as foot-and-mouth disease virus (FMDV), however, naked full-length viral RNA can itself be infectious. In order to assess the risk of infection from inactivated FMDV samples, two animal experiments were performed. In the first trial, six cattle were injected with FMDV RNA (isolate A22/IRQ/24/64) into the tongue epithelium. All animals developed clinical disease within two days and FMDV was reisolated from serum and saliva samples. In the second trial, another group of six cattle was exposed to FMDV RNA by instilling it on the tongue and spraying it into the nose. The animals were observed for 10 days after exposure. All animals remained clinically unremarkable and virus isolation as well as FMDV genome detection in serum and saliva were negative. No transfection reagent was used for any of the animal inoculations. In conclusion, cattle can be infected by injection with naked FMDV RNA, but not by non-invasive exposure to the RNA. Inactivated FMDV samples that contain full-length viral RNA carry only a negligible risk of infecting animals.

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Furman, E. G., A. O. Charushin, E. S. Eirikh, G. B. Furman, V. L. Sokolovsky, S. V. Malinin, V. S. Sheludko, D. A. Polyanskaya, N. M. Kalinina und D. K. Shtivelman. „Capabilities of computer analysis of breath sounds in patients with COVID-19“. Perm Medical Journal 38, Nr. 3 (16.07.2021): 97–109. http://dx.doi.org/10.17816/pmj38397-109.

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Objective. To develop methods for a rapid distance computer diagnosis of COVID-19 based on the analysis of breath sounds. It is known that changes in breath sounds can be the indicators of respiratory organs diseases. Computer analysis of these sounds can indicate their typical changes caused by COVID-19, and can be used for a rapid preliminary diagnosis of this disease. Materials and methods. The method of fast Fourier transform (FFT) was used for computer analysis of breath sounds, recorded near the mouth of 14 COVID-19 patients (aged 1880 years) and 17 healthy volunteers (aged 548 years). The frequency of breath sound records ranged from 44 to 96 kHz. Unlike the conventional methods of computer analysis for diagnosis of diseases based on respiratory sound studying, we offer to test a high-frequency part of FFT (20006000 kHz). Results. While comparing the breath sound FFT in patients and healthy volunteers, we developed the methods for COVID-19 computer diagnosis and determined the numerical criteria in patients and healthy persons. These criteria do not depend on sex and age of the examined persons. Conclusions. The offered computer methods based on the analysis of breath sound FFT in patients and volunteers permit to diagnose COVID -19 with relatively high diagnostic parameters. These methods can be used in development of noninvasive means for preliminary self-express diagnosis of COVID-19.

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Parsa, Elham, Mahmood Khodadoost, Roshanak Mokaberinejad, Morteza Mojahedi, Laila Shirbeigi, Armin Zareiyan und Mahshid Chaichi-Raghimi. „Gastric Dystemperament (Sue-mizaj) in Iranian Traditional Medicine“. Current Nutrition & Food Science 16, Nr. 6 (15.07.2020): 884–90. http://dx.doi.org/10.2174/1573401315666190821112354.

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Background: The stomach plays a vital role in the human body. Its clinical problems are very prevalent. : Nowadays, new branches of science have emerged because of human individual differences. Many medical schools such as Iranian Traditional Medicine (ITM) established the basis for the prevention, diagnosis, and treatment based on individual differences. Objective: The purpose of this study is to summarize identification indices of Gastric Dystemperament to help in better diagnosis. Methods: This was a qualitative review study. Definitions and symptoms of Stomach Dystemperament were derived from reliable sources of ITM from 900 AD to 1900 AD (Kamil-al-sinaa al Tibbiya, Teb-e-Akbari, Exir Azam, Al-Qanun fi al tibb, Mansouri Fi-al-teb, Al-Havi, Zakhire Kharazmshahi, Hidayat al-Muta’allemin fi al-tibb, Ferdos al-Hekmat fi al-tib, Sharh Al Qurashi al-Qanun, Sharh-e asbab al-Alamat) and English and Persian indices. Results: The most important factors and symptoms to be considered as gastric dystemperament include digestion, thirst, appetite, belching, bloating, gastric emptying time, burning stomach, reflux, gastric pain, the effect of food quality (coldness, heat, wet, dryness), mouth moisture and taste, tongue and mouth status, quality of body waste material (urine, stool), and palpation of the stomach area. Conclusion: Iranian Traditional Medicine sources have mentioned the indicators of gastric dystemperament, which can be used for more effective diagnosis and treatment and even prevention of gastric diseases.

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Yadav, Ruchi. „RNA-SEQ ANALYSIS TO EXPLORE THE VARIANTS IN MELANOMA CELLS: MOLECULAR DIAGNOSIS AND THERAPEUTICS“. Journal of medical pharmaceutical and allied sciences 11, Nr. 3 (30.06.2022): 4869–80. http://dx.doi.org/10.55522/jmpas.v11i3.2930.

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High throughput sequencing technology that are also called as second generation or Next Generation (NGS) sequencing techniques has enabled researchers to study genome, transcriptome, metabolome of any organism in high throughput manner. RNA seq (Ribonucleic Acid Sequencing) is a NGS technique that is used to sequence total transcripts of cell and to study gene expression. This technique is widely used to identify differentially expressed genes and to identify variants. RNAseq technique has been used to study several diseases like cancers, neurological diseases, bacterial infections diseases and to understand the key mechanism of genes and its functions. Melanoma is a threatening tumor and one of the most successive metastatic diseases. Melanomas ordinarily happen inside the skin yet inside the mouth, digestion tracts or eye. Melanoma carcinoma is also called as cutaneous melanoma or melanoma of the skin. In current research Pair end RNA-seq sequencing data for melanoma cell was retrieved from ENA (European Nucleotide Archive) database with accession no.:SRP252675. RNAseq analysis pipeline of Galaxy online platform was used for the prediction of single nucleotide variations (SNVs). Total three genes are predicted that are expressed in RNAseq samples and involved in the skin cancer these genes are TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily Member 4), TNFRSF18 and AGRN (Agrin). Protein encoded by TNFRSF4 gene is a member of the TNF-receptor superfamily and AGRN gene is associated with Presynaptic Congenital Myasthenic Syndromes. Pathway enrichment of identified genes shows that TNFRSF4 and TNFRSF18 have function in cytokine-cytokine receptor interaction and AGRN in ECM-receptor interaction. These results highlight the importance of TNFRSF4, TNFRSF18 and AGRN in Melanoma condition and can be further used as potential drug targets.

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Korostashova, M. A., V. M. Novikov, K. Yu Rezvina, A. I. Pankevich, I. A. Kolisnyk und A. M. Gogol. „CLINICAL AND RADIOLOGICAL PARALLELS IN DIAGNOSIS OF DISEASES AND DYSFUNCTION OF TEMPOROMANDIBULAR JOINT“. Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 22, Nr. 3-4 (29.11.2022): 126–30. http://dx.doi.org/10.31718/2077-1096.22.3.4.126.

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Introduction. Dysfunction of the temporomandibular joint is a rather widespread disorder and occupies a leading place among all other joint disorders. Subjects and methods. The study was conducted at the Department of Propaedeutics of Surgical Dentistry. 10 people with clinical signs of temporomandibular joint (TMJ) dysfunction were selected, and subjected to radiological and magnetic resonance imaging in order to clarify the final diagnosis. Results and discussion. The main criterion for magnetic resonance imaging diagnostics in dysfunctional TMJ conditions is visualization of the intra-articular cartilage disc. When comparing radiograms and magnetic resonance imaging, the main criteria were: Distortion between research methods; The presence of any bone formation and its importance in making a diagnosis. Comparing the series of radiograms and magnetic resonance imagings shows the distortion of the imaging results. In four patients, radiograms showed narrowing of the joint space in the anterior-posterior sections, but this did not occur on magnetic resonance imaging. In this case, patients should feel pain irradiating to the ear. This option is possible due to compression of the bilaminar zone, where the auriculotemporal nerve is located. Characteristic pathological symptoms were determined in one patient out of four that prompts the question about the correctness of determining the joint space on a series of radiograms. In these research methods, the following features were common: 1. The articular head was flattened (4 patients), had a dumbbell-like shape (6 patients). 2. With the mouth open, attention was drawn to the placement of the articular head in relation to the articular tubercle. Subluxation of one of the joints was found 8 patients; joint hypermobility was detected in 2 patients. Magnetic resonance imaging of the TMJ joint in 3 patients showed anatomical instability, namely degenerative changes in the articular discs, and bony growths. Degenerative changes of the meniscus did not occur in the other 7 patients. Conclusion. Undoubtedly, the best diagnosis when choosing the right method is based on the doctor's experience in correct image interpreting. Radiogram is a relatively cheap method compared to magnetic resonance imaging, but it is far from being exceptionally effective because it does not visualize the connective tissue elements of the joint. Magnetic resonance imaging fully characterizes all bone and soft tissue elements that helps the doctor to clearly determine the final diagnosis based on which the treatment plan will be made up.

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