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Zeitschriftenartikel zum Thema „Molecular genetics“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 29. Juli 2024

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1

G. Ushakiran, S. Ganga Sai Pradeepa, S. Lavanya, T. Sahithi Priya und P Krishna Kumari. „Molecular genetics“. World Journal of Advanced Research and Reviews 20, Nr. 3 (30.12.2023): 1035–39. http://dx.doi.org/10.30574/wjarr.2023.20.3.2057.

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Molecular genetics, is the study of the biochemical mechanisms of It is the study of the biochemical nature of the genetic material and it’s control of phenotype. It is the study of the connection between genotype and phenotype the connection was a chemical one. Molecular genetics often applies an "investigative approach" to determine the structure and function of genes in an organism's genome using genetic screens. Molecular genetics is a powerful methodology for linking mutations to genetic conditions that may aid the search for treatments for various genetics diseases. This field has provided insights into various biological processes, including gene regulation, heredity, evolution, and disease development. Molecular genetics techniques, such as PCR, DNA sequencing, and gene editing, have revolutionized our ability to manipulate and study genes. The integration of molecular genetics with other disciplines, like genomics and proteomics, has paved the way for advancements in personalized medicine and biotechnology .It involves analyzing the DNA and RNA molecules to understand how genetic information is stored, replicated, and expressed.

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D, Bhuvana. „Innovations in Molecular Biology-Cutting-Edge Breakthroughs in Molecular Genetics“. Annals of Experimental and Molecular Biology 6, Nr. 1 (24.01.2024): 1–4. http://dx.doi.org/10.23880/aemb-16000121.

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The field of molecular biology has experienced significant breakthroughs in recent years, driven by cutting-edge technologies and innovative research strategies. This abstract provides a concise overview of some key advancement that has shaped the landscape of molecular biology. One prominent area of progress involves the CRISPR-Cas9 gene editing system, which has revolutionized genetic manipulation. Researchers have refined and expanded its applications, enabling precise modifications to the genome for therapeutic purposes, functional genomics, and the development of genetically modified organisms. In the realm of nucleic acid sequencing, the advent of third-generation sequencing technologies has enhanced the accuracy and efficiency of deciphering complex genomes. Single-cell sequencing techniques have provided unprecedented insights into cellular heterogeneity, unraveling diverse cell populations within tissues and shedding light on the intricacies of developmental processes and disease progression. The integration of omics technologies, such as genomics, transcriptomics, proteomics, and metabolomics, has propelled systems biology to new heights. This holistic approach allows for a comprehensive understanding of biological systems, unveiling intricate molecular networks and signaling pathways. Advanced computational methods and artificial intelligence applications have played a pivotal role in processing and interpreting the vast amounts of data generated by these high-throughput techniques. Furthermore, the exploration of the microbiome's role in health and disease has gained momentum. Advances in metagenomics have enabled a deeper understanding of microbial communities, their interactions, and their impact on host physiology. The identification of specific microbial signatures associated with various diseases has opened avenues for novel therapeutic interventions and personalized medicine. Conclusion: Recent advances in molecular biology have transformed the field, offering unprecedented opportunities for scientific discovery and medical applications. The integration of cutting-edge technologies and interdisciplinary approaches continues to propel molecular biology forward, paving the way for new insights into the complexities of life at the molecular level

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3

Athanasiou, Y., M. Zavros, M. Arsali, L. Papazachariou, P. Demosthenous, I. Savva, K. Voskarides et al. „GENETIC DISEASES AND MOLECULAR GENETICS“. Nephrology Dialysis Transplantation 29, suppl 3 (01.05.2014): iii339—iii350. http://dx.doi.org/10.1093/ndt/gfu162.

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4

Stekrova, J., J. Reiterova, V. Elisakova, M. Merta, M. Kohoutova, V. Tesar, S. Suvakov et al. „Genetic diseases and molecular genetics“. Clinical Kidney Journal 4, suppl 2 (01.06.2011): 4.s2.28. http://dx.doi.org/10.1093/ndtplus/4.s2.28.

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5

Legendre, C., D. Cohen, Y. Delmas, T. Feldkamp, D. Fouque, R. Furman, O. Gaber et al. „Genetic diseases and molecular genetics“. Nephrology Dialysis Transplantation 28, suppl 1 (01.05.2013): i309—i321. http://dx.doi.org/10.1093/ndt/gft126.

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6

Wierzbicki, Anthony S. „Genetics and molecular biology: Genetic epidemiology“. Current Opinion in Lipidology 15, Nr. 6 (Dezember 2004): 699–701. http://dx.doi.org/10.1097/00041433-200412000-00011.

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7

Vázquez, José. „Molecular Genetics“. American Biology Teacher 65, Nr. 8 (01.10.2003): 634. http://dx.doi.org/10.2307/4451575.

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8

Vázquez, José. „Molecular Genetics“. American Biology Teacher 68, Nr. 4 (01.04.2006): 253–54. http://dx.doi.org/10.2307/4451977.

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9

&NA;. „Molecular genetics“. Current Opinion in Cardiology 12, Nr. 3 (Mai 1997): B91. http://dx.doi.org/10.1097/00001573-199705000-00017.

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10

Towbin, Jeffrey A. „Molecular genetics“. Current Opinion in Cardiology 16, Nr. 3 (Mai 2001): 187. http://dx.doi.org/10.1097/00001573-200105000-00005.

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11

&NA;. „Molecular Genetics“. Journal of Pediatric Hematology/Oncology 25, Nr. 4 (April 2003): S16—S17. http://dx.doi.org/10.1097/00043426-200304000-00035.

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12

Padua, R. A. „Molecular Genetics“. Journal of Medical Genetics 27, Nr. 3 (01.03.1990): 216. http://dx.doi.org/10.1136/jmg.27.3.216.

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13

Johnson, I. R. „Molecular genetics“. Current Obstetrics & Gynaecology 10, Nr. 3 (September 2000): 119. http://dx.doi.org/10.1054/cuog.2000.0134.

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14

McEwan, A. „Molecular genetics“. Current Obstetrics & Gynaecology 10, Nr. 3 (September 2000): 170–74. http://dx.doi.org/10.1054/cuog.2000.0135.

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15

Scott, Leland J. „Molecular genetics“. Electroencephalography and Clinical Neurophysiology 94, Nr. 5 (Mai 1995): 385–86. http://dx.doi.org/10.1016/0013-4694(95)90014-4.

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16

Commoner, Barry. „Molecular Genetics“. Organization & Environment 22, Nr. 1 (März 2009): 19–33. http://dx.doi.org/10.1177/1086026609333420.

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17

Super, M. „Molecular genetics“. Postgraduate Medical Journal 72, Nr. 854 (01.12.1996): 769. http://dx.doi.org/10.1136/pgmj.72.854.769-b.

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18

Albert, Daniel M. „Molecular Genetics“. Archives of Ophthalmology 113, Nr. 5 (01.05.1995): 565. http://dx.doi.org/10.1001/archopht.1995.01100050031023.

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19

Pato, Michele T., Humberto Nicolini und Carlos N. Pato. „Psychiatry and Molecular Genetics“. CNS Spectrums 4, Nr. 5 (Mai 1999): 16. http://dx.doi.org/10.1017/s1092852900011664.

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Molecular genetic studies of complex disorders require a number of parallel strategies. Many of the more familial psychiatric syndromes are highly prevalent and may represent a collection of a number of distinct genetic subtypes and possibly a number of nongenetic subtypes. A nongenetic form of illness may appear clinically indistinguishable from a genetic form. These nongenetic subtypes of a syndrome would be considered phenocopies. In this and the subsequent issue of CNS Spectrums, a number of papers are presented that review the current state of psychiatric genetics of major disorders. Clinical strategies to narrow phenotypes and better define study populations are paired with laboratory and statistical strategies to optimize both candidate gene and genome scanning methods.In this issue, Kennedy and colleagues focus on a review of the genetics of schizophrenia, highlighting genome scans already completed and studies on special populations. Schindler and colleagues present a unique and efficient method for defining the homogeneity of a study population, surname analysis, and the importance of population selection in the design of genetic studies. Macedo and colleagues demonstrate the study of anticipation in bipolar mood disorder. Genetic anticipation is the observation of an earlier age of onset and greater disease severity in younger generations. This pattern has been associated with dynamic repeat expansions in the DNA in several neuropsychiatric disorders, and represents a good example of a unique genetic mechanism causing a unique phenotypic pattern. Nicolini and colleagues present work done to date on obsessive-compulsive disorder.

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20

Brock, D. J. „A consortium approach to molecular genetic services. Scottish Molecular Genetics Consortium.“ Journal of Medical Genetics 27, Nr. 1 (01.01.1990): 8–13. http://dx.doi.org/10.1136/jmg.27.1.8.

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21

Pánková, K. „Stephen H. Howell – Molecular Genetics of Plant Development“. Czech Journal of Genetics and Plant Breeding 38, No. 3-4 (01.08.2012): 135–36. http://dx.doi.org/10.17221/6250-cjgpb.

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22

Casillas, Sònia, und Antonio Barbadilla. „Molecular Population Genetics“. Genetics 205, Nr. 3 (März 2017): 1003–35. http://dx.doi.org/10.1534/genetics.116.196493.

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23

Taylor, Matthew RG, Elisa Carniel und Luisa Mestroni. „Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing“. Expert Review of Molecular Diagnostics 4, Nr. 1 (Januar 2004): 99–113. http://dx.doi.org/10.1586/14737159.4.1.99.

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24

Monaco, Anthony P. „Human molecular genetics: Methods in molecular genetics (Vol. 8)“. Trends in Genetics 12, Nr. 11 (November 1996): 488. http://dx.doi.org/10.1016/0168-9525(96)83874-1.

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25

Pals, Gerard. „Molecular genetics, genetic testing, novel genome sequencing technologies“. Journal of thee Medical Sciences (Berkala Ilmu Kedokteran) 48, Nr. 04 (Suplement) (01.12.2016): 11. http://dx.doi.org/10.19106/jmedsciesup004804201609.

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26

Reichert, Matthias C., Rabea A. Hall, Marcin Krawczyk und Frank Lammert. „Genetic determinants of cholangiopathies: Molecular and systems genetics“. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864, Nr. 4 (April 2018): 1484–90. http://dx.doi.org/10.1016/j.bbadis.2017.07.029.

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27

Flood, Liam. „Genetics for Ent Specialists: The Molecular Genetic Basis of Ent Disorders (Genetics)“. Journal of Laryngology & Otology 119, Nr. 8 (August 2005): 665. http://dx.doi.org/10.1258/0022215054516340.

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28

CLEGG, M. T. „Molecular Evolution: Molecular Evolutionary Genetics.“ Science 235, Nr. 4788 (30.01.1987): 599. http://dx.doi.org/10.1126/science.235.4788.599.

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29

Kowalczyk, Marek, Ewelina Zawadzka, Dariusz Szewczuk, Magdalena Gryzińska und Andrzej Jakubczak. „Molecular markers used in forensic genetics“. Medicine, Science and the Law 58, Nr. 4 (30.09.2018): 201–9. http://dx.doi.org/10.1177/0025802418803852.

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Forensic genetics is a field that has become subject to increasing interest in recent years. Both the technology and the markers used for forensic purposes have changed since the 1980s. The minisatellite sequences used in the famous Pitchfork case introduced genetics to the forensic sciences. Minisatellite sequences have now been replaced by more sensitive microsatellite markers, which have become the basis for the creation of genetic profile databases. Modern molecular methods also exploit single nucleotide polymorphisms, which are often the only way to identify degraded DNA samples. The same type of variation is taken into consideration in attempting to establish the ethnicity of a perpetrator and to determine phenotypic traits such as the eye or hair colour of the individual who is the source of the genetic material. This paper contains a review of the techniques and molecular markers used in human and animal forensic genetics, and also presents the potential trends in forensic genetics such as phenotyping.

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Kyselová, Jitka, Ladislav Tichý und Kateřina Jochová. „The role of molecular genetics in animal breeding: A minireview“. Czech Journal of Animal Science 66, No. 4 (26.03.2021): 107–11. http://dx.doi.org/10.17221/251/2020-cjas.

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Current animal breeding approaches are strongly associated with the development of sophisticated molecular genetics methods and techniques. Worldwide expansion of genomic selection can be achieved by the identification of genetic DNA markers and implementation of the microarray (“chip”) technology. Further advancement was associated with next-generation sequencing methods, high-throughput genotyping platforms, targeted genome editing techniques, and studies of epigenetic mechanisms. The remarkable development of “omics” technologies, such as genomics, epigenomics, transcriptomics, proteomics and metabolomics, has enabled individual genomic prediction of animal performance, identification of disease-causing genes and biomarkers for the prevention and treatment and overall qualitative progress in animal production.

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Khrypunova, Tetiana. „Molecular Biology and Genetics Teaching at Different Levels of Education“. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, Nr. 5 (01.11.2020): 293–97. http://dx.doi.org/10.26693/jmbs05.05.293.

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This article is focused on mapping out the form and extent of education of genetics and molecular biology in high schools in Czech Republic and impact of liberalization of education compared to education in Slovac Republic, where education is partly liberalized, and Ukraine, where education is centralized. We have evaluated the available literature, subjective satisfaction of students and retrospective evaluation from absolvents of adequacy of education according to further studies on universities or colleges. In this article we concentrated on gymnasiums and lyceums, because genetics and molecular biology is taught (as separate disciplines) in these types of school and relevant part of students continue studying them in colleges and universities. Among the students of universities who answered the questions of our questionnaire were students of the biological, biochemical and medical faculties, because they were the ones who continue to study these subjects in universities. Material and methods. Our research was based on studying the available literature concerning current legislation of the selected countries (mainly the difference between education systems of countries), as well as surveys among middle and high school students, university students and secondary school teachers in the form of a questionnaire. We are aware of the fact that the amount of data we have obtained in the research is not entirely sufficient to create a picture of the overall situation, but we hope that the obtained data will still provide some insight into the situation as a whole. According to collected data we have divided taught topics into several categories: depending on the extent and depth of immersion in the topic of teaching; the degree to which they are understandable to students; and the degree to which the topics are sufficient for further study at universities. We compared the results of the above countries and outlined the relationship between them. Conclusion. We noted several changes that had occurred in education under the influence of the liberalization

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Guo, Ming, Xianglin Mao und Xiaoqing Ding. „Molecular genetics related to non-Hodgkin lymphoma“. Open Life Sciences 11, Nr. 1 (01.01.2016): 86–90. http://dx.doi.org/10.1515/biol-2016-0011.

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AbstractNon-Hodgkin lymphoma (NHL) is a serious disease, with a high proportion of mortality. Molecular genetic abnormalities are very common in NHL, but specific characterization in accordance to molecular genetics for lymphoma subtypes is not yet completed. This article summarizes the relationship between B- and T-NHL and molecular genetics. We focus on NHL subtypes and emphasize its features to figure out what is exposed about NHL genetics. The basis of this method is collection of biological specimens for genomic and genetic analyses. This summary may help to prompt prediction of outcomes and guide therapy in the future.

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Ferreira de Camargo, Gregório Miguel. „The role of molecular genetics in livestock production“. Animal Production Science 59, Nr. 2 (2019): 201. http://dx.doi.org/10.1071/an18013.

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Genetic variations that lead to easy-to-identify phenotypic changes have always been of interest to livestock breeders since domestication. Molecular genetics has opened up possibilities for identifying these variations and understanding their biological and population effects. Moreover, molecular genetics is part of the most diverse approaches and applications in animal production nowadays, including paternity testing, selection based on genetic variants, diagnostic of genetic diseases, reproductive biotechniques, fraud identification, differentiation of hybrids, parasite identification, genetic evaluation, diversity studies, and genome editing, among others. Therefore, the objective of this review was to describe the different applications of molecular genetics in livestock production, contextualising them with examples and highlighting the importance of the study of these topics and their applications.

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Beauchamp, Jonathan P., David Cesarini, Magnus Johannesson, Matthijs J. H. M. van der Loos, Philipp D. Koellinger, Patrick J. F. Groenen, James H. Fowler, J. Niels Rosenquist, A. Roy Thurik und Nicholas A. Christakis. „Molecular Genetics and Economics“. Journal of Economic Perspectives 25, Nr. 4 (01.11.2011): 57–82. http://dx.doi.org/10.1257/jep.25.4.57.

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The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all, should economists use and combine molecular genetic and economic data from these surveys? What challenges arise when analyzing genetically informative data? To illustrate, we present results from a “genome-wide association study” of educational attainment. We use a sample of 7,500 individuals from the Framingham Heart Study; our dataset contains over 360,000 genetic markers per person. We get some initially promising results linking genetic markers to educational attainment, but these fail to replicate in a second large sample of 9,500 people from the Rotterdam Study. Unfortunately such failure is typical in molecular genetic studies of this type, so the example is also cautionary. We discuss a number of methodological challenges that face researchers who use molecular genetics to reliably identify genetic associates of economic traits. Our overall assessment is cautiously optimistic: this new data source has potential in economics. But researchers and consumers of the genoeconomic literature should be wary of the pitfalls, most notably the difficulty of doing reliable inference when faced with multiple hypothesis problems on a scale never before encountered in social science.

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Craddock, Nick, und Ian Jones. „Molecular genetics of bipolar disorder“. British Journal of Psychiatry 178, S41 (Juni 2001): s128—s133. http://dx.doi.org/10.1192/bjp.178.41.s128.

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BackgroundA robust body of evidence from family, twin and adoption studies demonstrates the importance of genes in the pathogenesis of bipolar disorder. Recent advances in molecular genetics have made it possible to identify these susceptibility genes.AimsTo present an overview for clinical psychiatrists.MethodReview of current molecular genetics approaches and emerging findings.ResultsOccasional families may exist in which a single gene plays a major role in determining susceptibility, but the majority of bipolar disorder involves more complex genetic mechanisms such as the interaction of multiple genes and environmental factors. Molecular genetic positional and candidate gene approaches are being used for the genetic dissection of bipolar disorder. No gene has yet been identified but promising findings are emerging. Regions of interest include chromosomes 4p16, 12q23–q24, 16p13, 21q22, and Xq24–q26. Candidate gene association studies are in progress but no robust positive findings have yet emerged.ConclusionIt is almost certain that over the next few years the identification of bipolar susceptiblity genes will have a major impact on our understanding of disease pathophysiology. This is likely to lead to major improvements and treatment in patient care, but will also raise important ethical issues.

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Tillotson, Glenn S. „Staphylococcus: Molecular Genetics“. Expert Review of Anti-infective Therapy 6, Nr. 6 (Dezember 2008): 849–50. http://dx.doi.org/10.1586/14787210.6.6.849.

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37

Cummings, Michael R. „Medical Molecular Genetics“. Annals of Internal Medicine 128, Nr. 12_Part_1 (15.06.1998): 1052. http://dx.doi.org/10.7326/0003-4819-128-12_part_1-199806150-00038.

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38

Mitchell, Sharon E., und M. A. Hoy. „Insect Molecular Genetics“. Florida Entomologist 79, Nr. 3 (September 1996): 473. http://dx.doi.org/10.2307/3495602.

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MORGAN, M. J. „Molecular Cell Genetics“. Biochemical Society Transactions 14, Nr. 4 (01.08.1986): 792–93. http://dx.doi.org/10.1042/bst0140792a.

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40

Anderson, Page A. W. „Cardiovascular molecular genetics“. Current Opinion in Cardiology 9, Nr. 1 (Januar 1994): 78–90. http://dx.doi.org/10.1097/00001573-199401000-00010.

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41

Wallace, Bruce. „Molecular Evolutionary Genetics“. Journal of Heredity 79, Nr. 2 (März 1988): 139. http://dx.doi.org/10.1093/oxfordjournals.jhered.a110475.

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42

&NA;. „Cytogenetics/Molecular Genetics“. Journal of Pediatric Hematology/Oncology 25, Nr. 4 (April 2003): S4—S5. http://dx.doi.org/10.1097/00043426-200304000-00024.

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43

Whittaker, J. „Human Molecular Genetics“. Journal of Medical Genetics 33, Nr. 8 (01.08.1996): 720. http://dx.doi.org/10.1136/jmg.33.8.720-a.

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Trump, D. „Human Molecular Genetics“. Journal of Medical Genetics 34, Nr. 2 (01.02.1997): 176. http://dx.doi.org/10.1136/jmg.34.2.176-b.

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Ostrander, E. A. „Canine molecular genetics“. Animal Biotechnology 10, Nr. 3 (November 1999): 103. http://dx.doi.org/10.1080/10495399909525929.

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Chardon, P. „4. Molecular genetics“. Animal Genetics 20, Nr. 1 (24.04.2009): 84–111. http://dx.doi.org/10.1111/j.1365-2052.1989.tb01911.x.

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47

Ashley, Mary. „Molecular Conservation Genetics“. American Scientist 87, Nr. 1 (1999): 28. http://dx.doi.org/10.1511/1999.1.28.

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48

Gold, Scott. „Plant molecular genetics“. Crop Protection 16, Nr. 5 (August 1997): 491. http://dx.doi.org/10.1016/s0261-2194(97)84559-0.

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Nordborg, Magnus, und Hideki Innan. „Molecular population genetics“. Current Opinion in Plant Biology 5, Nr. 1 (Februar 2002): 69–73. http://dx.doi.org/10.1016/s1369-5266(01)00230-8.

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Pritchard, Catrin. „Molecular cell genetics“. Trends in Genetics 2 (Januar 1986): 143. http://dx.doi.org/10.1016/0168-9525(86)90205-2.

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