Auswahl der wissenschaftlichen Literatur zum Thema „Modular PKS engineering“
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Zeitschriftenartikel zum Thema "Modular PKS engineering"
Beck, Charlotte, Jaime Felipe Guerrero Garzón und Tilmann Weber. „Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines“. Biotechnology and Bioprocess Engineering 25, Nr. 6 (Dezember 2020): 886–94. http://dx.doi.org/10.1007/s12257-020-0265-5.
Der volle Inhalt der QuelleWesener, Shane R., Vishwakanth Y. Potharla und Yi-Qiang Cheng. „Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase“. Applied and Environmental Microbiology 77, Nr. 4 (23.12.2010): 1501–7. http://dx.doi.org/10.1128/aem.01513-10.
Der volle Inhalt der QuelleMusiol-Kroll, Ewa, und Wolfgang Wohlleben. „Acyltransferases as Tools for Polyketide Synthase Engineering“. Antibiotics 7, Nr. 3 (18.07.2018): 62. http://dx.doi.org/10.3390/antibiotics7030062.
Der volle Inhalt der QuelleRascher, Andreas, Zhihao Hu, Greg O. Buchanan, Ralph Reid und C. Richard Hutchinson. „Insights into the Biosynthesis of the Benzoquinone Ansamycins Geldanamycin and Herbimycin, Obtained by Gene Sequencing and Disruption“. Applied and Environmental Microbiology 71, Nr. 8 (August 2005): 4862–71. http://dx.doi.org/10.1128/aem.71.8.4862-4871.2005.
Der volle Inhalt der QuelleHe, Yunlong, Yuhui Sun, Tiangang Liu, Xiufen Zhou, Linquan Bai und Zixin Deng. „Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification“. Applied and Environmental Microbiology 76, Nr. 10 (26.03.2010): 3283–92. http://dx.doi.org/10.1128/aem.02262-09.
Der volle Inhalt der QuelleHaydock, Stephen F., Anthony N. Appleyard, Tatiana Mironenko, John Lester, Natasha Scott und Peter F. Leadlay. „Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449“. Microbiology 151, Nr. 10 (01.10.2005): 3161–69. http://dx.doi.org/10.1099/mic.0.28194-0.
Der volle Inhalt der QuelleAgergaard, Julie Krogh, Kristoffer Wernblad Sigsgaard, Niels Henrik Mortensen, Simon Didriksen, Kasper Barslund Hansen und Jingrui Ge. „MODULAR MAINTENANCE DECISION ARCHITECTURE“. Proceedings of the Design Society 3 (19.06.2023): 2715–24. http://dx.doi.org/10.1017/pds.2023.272.
Der volle Inhalt der QuelleWang, Guimei, Lijie Yang und Yong Shuo Zhang. „Modularized design of coal-mine paste filling station based on fuzzy theory“. World Journal of Engineering 15, Nr. 6 (03.12.2018): 743–50. http://dx.doi.org/10.1108/wje-01-2018-0006.
Der volle Inhalt der QuelleRana, Vighneshkumar, und Vishal Singh. „Analyzing the dimensional aspects of 3D volumetric spaces: a product-oriented perspective“. Proceedings of the Design Society 4 (Mai 2024): 2433–42. http://dx.doi.org/10.1017/pds.2024.246.
Der volle Inhalt der QuelleBreimann, Richard, Christoph Rennpferdt, Sven Wehrend, Eckhard Kirchner und Dieter Krause. „EXPLOITING THE SUSTAINABILITY POTENTIAL OF MODULAR PRODUCTS BY INTEGRATING R-IMPERATIVES INTO PRODUCT LIFE PHASES“. Proceedings of the Design Society 3 (19.06.2023): 1785–94. http://dx.doi.org/10.1017/pds.2023.179.
Der volle Inhalt der QuelleDissertationen zum Thema "Modular PKS engineering"
Su, Li. „Generation of analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches“. Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0081.
Der volle Inhalt der QuelleThe polyketide secondary metabolites of bacteria are a rich source of bioactive agents, with notable applications in anti-infective and anti-cancer therapy. However, their structures often need to be optimized in order to tailor their therapeutic and biophysical properties. The 51-membered macrolide stambomycins, among the largest of known polyketides, were recently discovered by genome mining in Streptomyces ambofaciens ATCC23877, and notably exhibit promising anti-cancer activity. The family encompasses six members which differ from each other in the alkyl functionality at C-26, due to the alternative choice of extender units by an exceptional acyl transferase domain (AT12) of the modular polyketide synthase (PKS) responsible for synthesizing the stambomycin core. Given their enormous size of the stambomycins and the intrinsic promiscuity of AT12, there is substantial interest in accessing ring-contracted and C-26 substituted derivatives of this compounds which might retain the bioactivity of the parental structures, or exhibit improved or even new properties. In this work, we have leveraged our current understanding of modular PKS systems to internally contract the stambomycin assembly line, leading to the successful generation, albeit at low yield, of target smaller derivatives (37-membered ‘mini-stambomycins’). By careful analysis, we could identify multiple factors contributing to the low titers, information which should inform future engineering strategies. Furthermore, using a mutasynthesis strategy, we were able to exploit the broad specificity of the AT12 domain to create 6 novel C-26 substituted stambomycin analogues. Finally, we unexpectedly identified three series of novel desferrioxamine siderophores produced by S. ambofaciens. As a number of key metabolites generated in this work have potential interest for therapeutic applications, they will be targeted for purification, structural characterization and biological evaluation
Zarzoso, Vicente. „Traitement aveugle et semi-aveugle du signal pour les télécommunications et le génie biomédical“. Habilitation à diriger des recherches, Université de Nice Sophia-Antipolis, 2009. http://tel.archives-ouvertes.fr/tel-00486872.
Der volle Inhalt der QuelleBuchteile zum Thema "Modular PKS engineering"
JianBing, Chen. „PEEK and PES ☆“. In Reference Module in Materials Science and Materials Engineering. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-803581-8.02607-2.
Der volle Inhalt der QuelleGlinsky, Albert. „A Eunuch in a Harem“. In Switched On, 80—C8.P38. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/oso/9780197642078.003.0008.
Der volle Inhalt der QuelleSubirats, X., E. Fuguet, M. Rosés, E. Bosch und C. Ràfols. „Methods for pKa Determination (I): Potentiometry, Spectrophotometry, and Capillary Electrophoresis“. In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11559-8.
Der volle Inhalt der QuelleQin, Weijin, Ya Liu und Xuhai Yang. „Performance Analysis on a Traceable Precise Satellite Timing“. In Advances in Transdisciplinary Engineering. IOS Press, 2022. http://dx.doi.org/10.3233/atde221204.
Der volle Inhalt der QuelleFuguet, E., X. Subirats, C. Ràfols, E. Bosch und M. Rosés. „Methods for pKa Determination (II): Sparingly Soluble Compounds and High-Throughput Approaches“. In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-409547-2.11631-2.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Modular PKS engineering"
Zhang, Dan, Lihui Wang und Sherman Y. T. Lang. „Modelling and Control of PKM in an Integrated Environment“. In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/cie-48178.
Der volle Inhalt der QuelleKitzmiller, John T., Richard G. Anderson, Laura L. Genutis und Dennis M. Popp. „Effects on Core Damage Frequency to Sensitivity of Instrumentation and Control Reliability“. In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75413.
Der volle Inhalt der QuelleHan, Changwan, Seonghun Park und Hanjong Kim. „Dynamic Response of Polyvinyl Alcohol(PVA)-Hydrogel With Different PVA Concentrations“. In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37811.
Der volle Inhalt der QuelleEilmus, Sandra, und Dieter Krause. „Product Life-Oriented Development of Component Commonality and Variety“. In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-63619.
Der volle Inhalt der QuelleMüller, Andreas. „A Lie Group Approach to the Modular Modeling of Kinematically Non-Redundant Parallel Mechanisms“. In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-98283.
Der volle Inhalt der QuelleZhang, Dan, Lihui Wang und Sherman Y. T. Lang. „An Integrated Virtual Validation System for Parallel Kinematic Machine Analysis Design“. In ASME 2003 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/detc2003/dac-48825.
Der volle Inhalt der QuelleChen, Hui, und Zhixing Wang. „Computer Aided Manufacturing of Marine Propellers by Parallel Kinematics Machine“. In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-41727.
Der volle Inhalt der QuellePradhan, A. K., A. Routray und A. Behera. „Power quality disturbance classification employing modular wavelet network“. In 2006 IEEE Power Engineering Society General Meeting. IEEE, 2006. http://dx.doi.org/10.1109/pes.2006.1709452.
Der volle Inhalt der QuelleWehlin, Camilla, Olle Vidner, Leon Poot und Mehdi Tarkian. „Integrating Sales, Design and Production: A Configuration System for Automation in Mass Customization“. In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-68426.
Der volle Inhalt der QuelleYu, Mingrui, Hongliang Wang, Zhuo Liu, Yu Feng, Xu Han und Yidan Yuan. „Experimental Research on Drag Characteristic of Air Flow Path for ACP-100 Passive Containment Air Cooling System“. In 2022 29th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/icone29-91504.
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