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1
Rada, Dominik. „Přenosová technologie G.mgfast“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442370.
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The master thesis deals with G.fast and G.mgfast transmission technologies, including their parameters. The work deals with the principle of vector DMT modulation and the possibility of time duplex TDD and full-duplex FDX in two-way communication used in these technologies. The following is a description of the line using the KHM model, which is suitable for simulations in the transmission band using G.fast and G.mgfast technologies. Subsequently, the disturbing effects of crosstalk at the near end of NEXT and the far end of FEXT and their elimination with these technologies are discussing. Part of the work explains supporting calculations to determine the SNR and bit allocation to calculate the baud rate. The work describes the methods of compensation of crosstalk FEXT and NEXT, which affect the resulting baud rate. The work also includes an application for simulation of transmission speed as a function of distance for G.fast and G.mgfast technologies, allowing changing input parameters and adjusting the transmission bandwidth based on G.9700 and G.9701 standards. Also, in work, an application is created to display the compensation of the influence of the transmitted signal crosstalk FEXT and NEXT, which allow the import of measured crosstalk between individual participants. The issue of influencing crosstalk for accurate measurements in the laboratory is also discussing. An application in the MATLAB environment is creating to display the measured characteristics.
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Wallez, Thomas. „Invariants iso-spectraux et théorèmes KAM“. Thesis, Nantes, 2018. http://www.theses.fr/2018NANT4067/document.
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L’objectif de ce travail est d’établir des résultats de rigidité spectrale pour des familles C1 d’opérateurs (pseudo-)différentiels elliptiques auto-adjoints Pt, t ϵ [0, ẟ] sur une variété lisse compacte M sans bord de dimension n ≥ 2. Dans les deux premiers chapitres, on étudie des hamiltoniens proches d’un hamiltonien intégrable qui est non dégénéré au sens de Kolmogorov (Système KAM). On y construit une forme normale de Birkhoff au voisinage de chaque tore KAM ayant une fréquence diophantienne. Dans les chapitres 3 et 4 on établit une forme normale de Birkfoff quantique afin de construire des familles C1 de quasi-modes. Ces dernières permettent de relier les propriétés spectrales de Pt aux propriétés dynamiques des tores KAM. Les deux derniers chapitres proposent des applications en lien avec la transformée de Radon ainsi qu’une étude sur les surfaces de rotationThe aim of this work is to obtain spectral rigidity results for C1 families of elliptic self-adjoint (pseudo-)differential operators Pt, t ϵ [0, ẟ], on a smooth closed manifold M of dimension n ≥ 2. In the first two chapters, we investigate Hamiltonians close to a given integrable Hamiltonian which is non-degenerate in the sense of Kolmogorov (KAM system). This allows us to obtain a Birkhoff normal form in a neighborhood of any KAM tori with a Diophantine frequency. In the third and fourth chapters, we construct a quantum Birkhoff normal form and obtain C1 families of quasimodes. Using the quasi-modes, we establish a connection between the spectral properties of Pt and the dynamical properties of the KAM tori. The last two chapters provide applications of these results to the Radon transform and the surfaces of revolution
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Bryksa, Vadym. „Electronic correlation and magnetism in multi-band Kondo lattice model“. Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16096.
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Es wird eine selbstkonsistente, approximative L\"osung f\"ur das verd\"unnte, ungeordnete Kondo-Gitter-Modell (KLM) vorgeschlagen, um die miteinander verkn\"upften elektronischen und magnetischen Eigenschaften von sogenannten ''local moment''-Systemen wie den verd\"unnten magnetischen Halbleitern zu diskutieren. Untersucht werden Verbindungen der Form $A_{1-x}M_x$, in denen magnetische ($M$) und nicht-magnetische Atome ($A$) statistisch \"uber das Kristallgitter verteilt sind. Die Kopplung zwischen den lokalisierten Momente und den quasi-freien Elektronen (L\"ocher) wird im Rahmen einer modifizierten RKKY-Theorie behandelt, die das KLM auf ein effektives Heisenberg-Modell abbildet. Die Unordnungen in dem elektronischen Teilsystem und in dem magnetischen Momentensystem werden nach Methoden behandelt, die der ''coherent potential approximation'' (CPA) angepa{\ss}t sind. Es wird eine Erweiterung der CPA zur Berechnung der sich wechselseitig bedingenden elektronischen und magnetischen Eigenschaften verd\"unnter ''local moment''-Systeme vom Typ $A_{1-x}M_x$ f\"ur die Situation vorgeschlagen, in der eine durch Kristallfeldparameter bedingte Unordnung in der N\"{a}chste-Nachbar-Schale des Aufatoms ber\"ucksichtigt werden mu\ss. Dabei werden Kristallfeldparameter zwischen zwei nicht-magnetischen Atomen ($\lambda^{AA}$), zwischen einem magnetischen und einem nicht-magnetischen Atom ($\lambda^{AM}$) und zwischen zwei magnetischen Atomen ($\lambda^{MM}$) unterschieden. Schl\"usselgr\"o{\ss}en wie die langreichweitigen und oszillierenden effektiven Austauschintegrale und die Curie-Temperatur und die elektronischen und magnonischen Quasiteilchen-Zustandsdichten werden im Detail in Abh\"angigkeit der Konzentration $x$ der magnetischen Ionen, der Ladungstr\"ager-Konzentration $n$, der Interband-Austauschkopplung $J$, der Temperatur und der Kristallfeldparameter untersucht.We propose a self-consistent approximate solution of the disordered Kondo-lattice model (KLM) to get the interconnected electronic and magnetic properties of ''local-moment'' systems like diluted ferromagnetic semiconductors. Aiming at $(A_{1-x}M_x)$ compounds, where magnetic (M) and non-magnetic (A) atoms are distributed randomly over a crystal lattice, we present a theory which treats the subsystems of itinerant charge carriers and localized magnetic moments in a homologous manner. The coupling between the localized moments due to the itinerant electrons (holes) is treated by a modified RKKY-theory which maps the KLM onto an effective Heisenberg model. The disordered electronic and magnetic moment systems are both treated by coherent potential approximation (CPA) methods. An extension of CPA to perform a self-consistent model calculation of the electronic and magnetic properties of diluted local-moment systems $A_{1-x}M_x$ described by ferromagnetic Kondo-lattice model ($s-f$ model), where we included disorder in the first environment shell by use of crystal field parameters between two non-magnetic, one magnetic and non-magnetic, and two magnetic atoms, respectively $\lambda^{AA},\lambda^{AM},\lambda^{MM}$, and to get the interconnected electronic and magnetic properties of systems like diluted ferromagnetic semiconductors (DMS) is proposed. We discuss in detail the dependencies of the key-terms such as the long range and oscillating effectice exchange integrals and the Curie temperature as well as the electronic and magnonic quasiparticle densities of states on the concentration $x$ of magnetic ions, the carrier concentration $n$, the exchange coupling $J$ and the crystal field parameters.
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Villumsen, Erika, und Jennifer Laurits. „In search for the perfect KAM manager : Exploring both the buyer´s and the supplier’s view of valued personality traits in a KAM manager“. Thesis, Jönköping University, Internationella Handelshögskolan, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52981.
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Background: KAM has received a lot of attention over the last decade, where organizations acknowledge the benefits, and choose to implement KAM programs within their companies. Research shows that the individual in a KAM manager role has a huge impact on the outcomes of KAM, crucially responsible for the relationships with the key accounts. Furthermore, there is a clear link between the selection of the right candidate in order to succeed with KAM, and the personality traits of a KAM manager. Problem: Limited research has been carried out on the personality traits of KAM managers connected to the FFM, yet scholars indicate that the individual has a large effect on the outcomes of KAM. Also, few researchers study both the buyer´s and the supplier's side within KAM relationships, even though mutual benefits are an essential part of KAM. Purpose: The purpose of the study is to identify if there is an existing mutual understanding between the buyer and supplier regarding valuable traits of a KAM manager to benefit KAM outcomes. Method: The study utilizes a qualitative research approach, collecting primary data through six semi-structured interviews. The number of participants was equally distributed between buyers and suppliers, all experienced working with KAM. A thematic analysis was then used to analyze the empirical findings. Conclusion: Based on the results, a conclusion is drawn that there is no mutual understanding between the buyer and supplier regarding valuable traits of a KAM manager. Aligning with previous research, all participants shared the view concerning the individual's importance in KAM, however having divided opinions about which personality traits would contribute to the valuable outcomes. The buyers emphasized the importance of structure and planning relating to the personality trait conscientiousness to optimize KAM outcomes, while the suppliers rather placed focus on aspects connecting to the personality trait extraversion.
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Kahm, Matthias [Verfasser]. „A Mathematical Model of the Potassium Homeostasis in Saccharomyces cerevisiae / Matthias Kahm“. Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044080957/34.
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6
Blöchlinger, Lea. „Power Prices - A Regime-Switching Spot/Forward Price Model with Kim Filter Estimation“. kostenfrei, 2008. http://www.biblio.unisg.ch/www/edis.nsf/wwwDisplayIdentifier/3442.
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7
Gleave, Terrence Lee. „KIM-2 : a model mammary epithelial cell line for the study of exocytosis“. Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343755.
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8
Fang, Zaili. „Some Advanced Model Selection Topics for Nonparametric/Semiparametric Models with High-Dimensional Data“. Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/40090.
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Model and variable selection have attracted considerable attention in areas of application where datasets usually contain thousands of variables. Variable selection is a critical step to reduce the dimension of high dimensional data by eliminating irrelevant variables. The general objective of variable selection is not only to obtain a set of cost-effective predictors selected but also to improve prediction and prediction variance. We have made several contributions to this issue through a range of advanced topics: providing a graphical view of Bayesian Variable Selection (BVS), recovering sparsity in multivariate nonparametric models and proposing a testing procedure for evaluating nonlinear interaction effect in a semiparametric model.
To address the first topic, we propose a new Bayesian variable selection approach via the graphical model and the Ising model, which we refer to the ``Bayesian Ising Graphical Model'' (BIGM). There are several advantages of our BIGM: it is easy to (1) employ the single-site updating and cluster updating algorithm, both of which are suitable for problems with small sample sizes and a larger number of variables, (2) extend this approach to nonparametric regression models, and (3) incorporate graphical prior information.
In the second topic, we propose a Nonnegative Garrote on a Kernel machine (NGK) to recover sparsity of input variables in smoothing functions. We model the smoothing function by a least squares kernel machine and construct a nonnegative garrote on the kernel model as the function of the similarity matrix. An efficient coordinate descent/backfitting algorithm is developed.
The third topic involves a specific genetic pathway dataset in which the pathways interact with the environmental variables. We propose a semiparametric method to model the pathway-environment interaction. We then employ a restricted likelihood ratio test and a score test to evaluate the main pathway effect and the pathway-environment interaction.Ph. D.
9
Anisimova, Lyubov. „Nonlinear susceptibility study in superconductors based on Bean and Kim-Anderson models“. Diss., Online access via UMI:, 2009.
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Almeida, Michael Aparício de. „Equity research da Air France - KLM“. Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/19085.
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Mestrado em Contabilidade, Fiscalidade e Finanças EmpresariaisA Air France-KLM (AF-KLM) é a companhia de bandeira da França, é resultado da fusão entre as empresas Air France (francesa) e KLM (holandesa) possuindo dois hubs principais situados em Paris e Schipol. O grupo é atualmente líder da europa em termos de tráfego e tem como objetivo ser uma das maiores companhias à escala global. O trabalho final de mestrado que se segue tem como objetivo principal estimar o valor intrínseco das ações da AF-KLM para 31 de dezembro de 2018. Este projeto é composto por uma revisão bibliográfica onde são analisados os métodos de avaliação possíveis e a partir da qual é definida a metodologia para este mesmo projeto. Foi também feita uma análise em relação ao ambiente macroeconómico, da indústria e especificamente da AF-KLM. De forma a calcular o valor intrínseco procedeu-se à avaliação por fluxos de caixa atualizados baseado em valores de FCFF pelo qual foi determinado um valor intrínseco de 11.33 euros para as ações da AF-KLM para a data de 31 de dezembro de 2018. Este valor sugere que as ações se encontram subvalorizadas e que possuem um potencial de crescimento de 19.55% face ao preço de 9.48 euros registado a 31 de dezembro de 2018. Através da avaliação relativa foram utilizados dois múltiplos, em que o enterprise valueto-EBITDA resultou num preço de 23.5 euros por ação e o price-to-earnings foi igual a 5.3 euros por ação culminando numa média de 14.43 euros por ação que corresponde a um potencial de crescimento de 52.2%.
Air France-KLM (AK-KLM) is the flag carrier of France resulted of the fusion between Air France (french) and KLM (dutch). It has two main hubs located in Paris and Schipol. The group is the current european leader in passenger traffic and aims to be one of the world's best airline companies. The following project aims to estimate the intrinsic value of AF-KLM's stock price as of December 31, 2018. It consists of a literature review where possible evaluation methods are analysed from which the methodology of this project is defined. An analysis was also made of the macroeconomic environment, industry and the company's specifics. In order to estimate the intrinsic value, cash flow discount model based on FCFF values was carried out whereby an intrinsic value of 11.33 euros was determined for AFKLM's shares as of 31 December 2018. This result suggests that shares are undervalued and have a growth potential of 19.55% compared to the closing price of 31 December 2018 (9.48 euros). Through the relative valuation two multiples were used, in which enterprise-value-to-EBITDA resulted in 23.5 euros per share and where the price-toearnings ratio gave a price of 5.3 euros per share, culminating in an average of 14.43 euros per share which corresponds to a growth potential of 52.2%.
info:eu-repo/semantics/publishedVersion
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Huang, Shenwen. „The Effect of 120-kHz Ultrasound on Thrombolytic Efficacy in Porcine Thromboembolism Models“. University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511884862297255.
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12
Neitzert, Kim [Verfasser]. „The role of the CC chemokine CCL17 in a mouse model of Alzheimer's disease / Kim Neitzert“. Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1054692017/34.
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13
Kim, Youjin [Verfasser], Taeseong [Akademischer Betreuer] Kim und Antonio [Gutachter] Delgado. „Computational airfoil optimization for the improvement of the performance of horizontal axis wind turbines (HAWT) with a 3D model / Youjin Kim ; Gutachter: Antonio Delgado ; Betreuer: Taeseong Kim“. Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1213533341/34.
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Durelli, Rafael Serapilha. „Uma abordagem para criação, reúso e aplicação de refatorações no contexto da modernização dirigida a arquitetura“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-29092016-145938/.
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A Modernização Dirigida a Arquitetura (do inglês - Architecture-Driven Modernization (ADM)) é uma iniciativa do Object Management Group (OMG) no sentido de padronizar os tradicionais processos de reengenharia de software utilizando metamodelos. O metamodelo mais importante da ADM é o Knowledge Discovery Metamodel (KDM), cujo objetivo é representar todos artefatos de um determinado sistema, de forma independente de linguagem e plataforma. Um passo primordial durante processos de modernização de software é a aplicação de refatorações. No entanto, até o presente momento, há carência de abordagens que tratam das questões referentes a refatorações no contexto da ADM, desde a criação até a aplicação das mesmas. Além disso, atualmente, não existe uma forma sistemática e controlada de facilitar o reúso de refatorações que são específicas do KDM. Diante disso, são apresentados uma abordagem para criação e disponibilização de refatorações para o metamodelo KDM e um apoio ferramental que permite aplicá-las em diagramas de classe da UML. A abordagem possui dois passos: (i) o primeiro envolve passos que apoiam o engenheiro de modernização durante a criação de refatorações para o KDM; (ii) o segundo resume-se na especificação das refatorações por meio da criação de instâncias do metamodelo Structured Refactoring Metamodel (SRM) e posterior disponibilização delas em um repositório. O apoio ferramental, denominado KDM-RE, é composto por três plug-ins do Eclipse: (i) o primeiro consiste em um conjunto de Wizards que apoia o engenheiro de software na aplicação das refatorações em diagramas de classe UML; (ii) o segundo consiste em um módulo de propagação de mudanças, permitindo manter modelos internos do KDM sincronizados; (iii) o terceiro fornece apoio à importação e reúso de refatorações disponíveis no repositório. Além disso, o terceiro módulo também contém uma linguagem específica de domínio, a qual é utilizada para auxiliar o engenheiro de software a instanciar o metamodelo SRM. Foi realizado um experimento, buscando reproduzir os cenários em que engenheiros de software realizam refatorações em instâncias do metamodelo KDM. Os resultados mostraram que a abordagem, bem como o apoio ferramental podem trazer benefícios para o engenheiro de software durante a atividade de aplicação de refatorações em sistemas, representados pelo metamodelo KDM.Architecture Driven Modernization (ADM) is an initiative of the Object Management Group (OMG) whose main purpose is to provide standard metamodels that enable the conduction of modernization activities as reverse engineering and software transformation. In this context, the most important metamodel is the Knowledge Discovery Metamodel (KDM), whose objective is to represent software artifacts in a language- and platform-agnostic fashion. A fundamental step during software modernization is refactoring. However, there is a lack of approaches that address how refactoring can be applied in conjunction with ADM. In addition, few efforts have investigated how refactorings can be reused and systematically applied within the context of KDM representations. We propose an approach for creating and cataloging refactorings tailored to KDM. Our approach is twofold: (i) the first part comprises steps that help the software modernization engineer create KDM-compliant refactorings; (ii) the second part has to do with turning these refactoring descriptions into Structured Refactoring Metamodel (SRM) and making them available to be reused. To automate these activities, we developed a tool that makes it possible to apply refactorings to Unified Modeling Language (UML) class diagrams. Our tool, named KDM-RE, comprises three Eclipse plug-ins, which can be briefly described as follows: (i) a set of Wizards aimed at supporting the software modernization engineer during refactoring activities; (ii) a change propagation module that keeps the internal metamodels synchronized; and (iii) a plug-in that supports the selection and reuse of the refactorings available in the repository. Moreover, we developed a domain specific language to minimize the effort required to instantiate SRMs. We carried out an evaluation that simulates how software modernization engineers would go about refactoring KDM instances. Our results would seem to suggest that our approach, when automated by our tool, provides several advantages to software modernization engineers refactoring systems represented by KDMs.
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Kim, Jongwoon [Verfasser]. „Prediction of mixture toxicity using computational toxicology methods - towards integrated model for environmental risk assessment / Jongwoon Kim“. Landau : Universitätsbibliothek Landau, 2013. http://d-nb.info/1038653967/34.
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Sidiqi, Mahjooba. „The structure and RNA-binding of poly (C) protein 1“. University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0077.
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[Truncated abstract] Regulation of mRNA stability is an important posttranscriptional mechanism involved in the control of gene expression. The rate of mRNA decay can differ greatly from one mRNA to another and may be regulated by RNA-protein interactions. A key determinant of mRNA decay are sequence instability (cis) elements often located in the 3' untranslated region (UTR) of many mRNAs. For example, the AU rich elements (AREs), are such well characterized elements, and most commonly involved in promoting mRNA degradation, and specific binding of proteins to these elements leading to the stabilization of some mRNAs. Other cis-elements have been described for mRNA in which mRNA stability is a critical component of gene regulation. This includes the androgen receptor (AR) UC-rich cis element in its 3'UTR. The AR is a key target for therapeutics in human prostate cancer and thus understanding the mechanism involved in regulating its expression is an important goal. The [alpha]CP1 protein, a KH-domain containing RNA-binding protein has been found to bind this UC-rich region of the AR and is thought to play an important role in regulating AR mRNA expression. [alpha]CP1 protein is a triple KH (hnRNP K homology) domain protein with specificity for Crich tracts of RNA and ssDNA (single stranded DNA). Relatively little is known about the structural interaction of [alpha]CP1 with target RNA cis elements, thus the present study aimed to better understand the nature of interaction between 30 nt 3'UTR UC-rich AR mRNA and [alpha]CP1 protein using various biophysical techniques, in an attempt to determine which [alpha]CP1 domain or combination of domains is involved in RNA-binding. These studies could ultimately provide novel targets for drugs aimed to regulate AR mRNA expression in prostate cancer cells. At the commencement of this study little was known about the structure of the [alpha]CP1- KH domains and their basis for poly (C) binding specificity. ... Additional studies addressed the significance of the four core recognition nucleotides (TCCC) using a series of cytosine to thymine mutants. The findings verified some of the results predicted from structural studies, especially the need for maximum KH binding to a core tetranucleotide recognition sequence. Our mutational studies of the four core bases confirmed the importance of cytosine in positions two and three as no binding was observed, while some binding was observed when the fourth base was mutated. In summary, the work presented in this thesis provides new detailed insight into the molecular interactions between the [alpha]CP1-KH domain and AR mRNA. Furthermore, these studies shed light on the nature of protein/mRNA interactions in general, as well as the specific complex that forms on AR mRNA. These studies have provided new understanding into the mode of [alpha]CP1 binding at a target oligonucleotide binding site and, provide a foundation for future studies to define structure of multiprotein/oligonucleotide complexes involved in AR mRNA gene regulation. Understanding the detailed interaction between the AR mRNA and [alpha]CP1 could provide possible targets for drug development at reducing AR expression in prostate cancer cells by interfering with the interaction of [alpha]CP1 and AR-mRNA.
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Lönnberg, Oscar, und Alice Hägnander. „Underhåll och förbättring av leverantörsrelationer : En fallstudie på ett speditörföretag“. Thesis, Tekniska Högskolan, Jönköping University, JTH, Logistik och verksamhetsledning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-49964.
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Syfte – En förstudie på fallföretaget identifierade ett problem som ledde till att syftet och frågeställningarna formulerades. Studien syfte innebär att undersöka hur underhåll av en leverantörsrelation kan påverka ett speditörföretag. För att svara på studiens syfte har det brutits ner i två frågeställningar: Hur arbetar ett speditörföretag med sina leverantörsrelationer? Vilka är möjligheterna till att förbättra en leverantörsrelation? Metod – Studien är genomförd som en fallstudie med enfallsdesign. Empiri är insamlat med intervjuer, dokumentstudier och litteraturstudier. Litteraturstudien utgör grunden för studiens teoretiska ramverk som innehåller teorier inom leverantörssegmentering, interaktionsmodellen, Customer Relationship Management (CRM) och Key Account Management (KAM). Resultat – Studiens resultat innefattar att underhåll av leverantörsrelationer med hjälp av leverantörssegmentering, interaktionsmodellen, Customer Relationship Management (CRM) och Key Account Management (KAM) på ett fördelaktigt sätt bidrar till ett bra underhåll av leverantörsrelationer och förbättringsmöjligheter till tätare relationer. Implikationer – Med hjälp av befintliga teorier inom relationshantering bidrar studien med att underhålla och förbättra leverantörsrelationer. Studien riktar sig emot ett mindre utforskat område för transport- och speditörföretags underhåll och förbättringar av leverantörsrelationer. Begränsningar – Studien är utförd enbart på ett speditörföretag vilket begränsar studiens generaliserbarhet vilket påverkar studiens resultat. Studien har inte tagit hänsyn till kostnader för implementering för förbättringsåtgärder i arbete för bättre relationer samt att leverantörens synvinkel inte är undersökt.Purpose – A pilot study at the case company identified a problem that lead to the purpose and research questions. The purpose of this study is to investigate how maintenance of a supplier relationship can affect a forwarder company. To answer the study's purpose, it has been broken down into two research questions: How does a freight forwarding company work with its supplier relationships? What are the opportunities to improve a supplier relationship? Method - The study is conducted as a case study with one-case design. Data is collected with interviews, document studies and literature studies. With the literature study, the basis for the study's theoretical framework contains theories in supplier segmentation, the interaction model, Customer Relationship Management (CRM) and Key Account Management (KAM). Results - The study's results include that maintenance of supplier relationships by means of supplier segmentation, the interaction model, Customer Relationship Management (CRM) and Key Account Management (KAM) in a beneficial way contributes to good maintenance of supplier relationships and improvement opportunities for closer relationships. Implications - Using existing relationship management theories, the study helps to maintain and improve supplier relationships. The study targets a less explored area for transport and freight forwarding companies' maintenance and improvements in supplier relationships. Limitations - The study is conducted only at one freight forwarding company which limits the generalizability of the study which affects the study's results. The study has not taken into account the costs of implementation for improvement measures in work for better relationships and that the supplier's point of view has not been examined.
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Kurian, Kathreena Mary. „Characterisation of KIM 2 murine mammary epithelial cells and reversion of the transformed phenotype via Tiam1 : a model for suppression of transformation in breast cancer?“ Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/23080.
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The KIM2 mammary cell line, containing a temperature dependent SV40 large T antigen, was used as a model for normal and transformed mammary epithelial cells. At 37°C the mammary cell line appears epithelial and showed mammary differentiation (NKIM2), whereas at 33°C the cell line appears spindle-shaped and transformed (TKIM2). The aim of this study was therefore to determine the biological features of the NKIM2 and TKIM2 lines, revert the transformed TKIM2 to a non-transformed phenotype by retrovirally transducing Tiam 1 into the cell lines, assess the reverted cells in terms of the originally defined biological features, and explore new targets in the signalling pathway leading to phenotype reversion. The NKIM2 cell line showed features of epithelial differentiation including morphology, E-cadherin and ZO-1 expression, junctions and polarisation. In addition, the specialised myoepithelial cell type was identified among cultures. The NKIM2 cells also showed mammary differentiation in terms of milk protein expression in response to lactogenic hormones. However, the significance of the formation of dome-like structures in response to lactogenic stimuli remains unclear. The TKIM2 line demonstrated all the accepted features of transformation including morphology, lack of contact inhibition or serum dependence, anchorage independence in soft agar and tumour formation in scid mice. Unexpectedly, the NKIM2 lines also formed tumours in scid mice. This may have been a consequence of SV40 large T antigen binding p53 and resulting in a variable chromosomal content in both NKIM2 and TKIM2. There was no difference in the chromosomal locus for p53 and SEN6, which have been implicated in transformation and immortalisation respectively, in both cell lines. Retroviral transduction of control and active Tiam 1 constructs into both NKIM2 and TKIM2 lines was successful, with Tiam 1 protein expression in transduced cell lines at least three months after transduction.
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Habrard, Florian. „Élaboration de dispositifs et matériaux mixtes à base de polymères conjugués électroluminescents“. Phd thesis, Université Joseph Fourier (Grenoble), 2006. http://tel.archives-ouvertes.fr/tel-00130247.
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Le sujet de cette thèse se situe dans le contexte de l'électronique organique à base de polymères conjugués. Nous avons choisi la famille des polyfluorènes principalement en raison de leur émission dans le bleu, leur bon rendement quantique ainsi que pour la facilité avec laquelle on peut modifier leurs propriétés en greffant différents groupements fonctionnels sur la structure de base du fluorène. L'originalité des recherches effectuées au laboratoire concerne la structure des dispositifs électroluminescents (cellules électrochimiques électroluminescentes ou OLEC) que nous réalisons. Leur principe de fonctionnement repose sur l'utilisation de liquides ioniques ajoutés directement au polymère conjugué sans l'intervention d'un polymère conducteur ionique. Le travail réalisé au cours de cette thèse a principalement consisté à tenter d'améliorer les performances du polyfluorène par l'utilisation de groupements fonctionnels permettant d'augmenter la compatibilité polymère / liquide ionique. Dans cette optique, nous avons mis en œuvre l'utilisation d'un outil de caractérisation particulièrement adapté à nos échantillons : la microscopie à force atomique en mode EFM ou KFM. Cela nous a permis de visualiser précisément la séparation de phase entre le polymère et le liquide ionique. Nous avons ainsi pu montrer que le courant dans un dispositif était grossièrement proportionnel à l'interface polymère / liquide ionique. Nous avons alors proposé une hypothèse expliquant le mode de vieillissement des OLEC. L'amélioration du mélange, c'est-à-dire la maximisation de l'interface polymère / liquide ionique devrait ainsi permettre d'améliorer la durée de vie des dispositifs. L'utilisation de groupements PEO et cyano greffés sur le polyfluorène semble une voie à explorer. Enfin, nous avons décrit le comportement particulier du mélange polyfluorène cyano – THA-TFSI dont la morphologie évolue suivant les conditions de température et de pression.
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Alsadhan, Abdulaziz O. A. „The implementation of knowledge management systems: An empirical study of critical success factors and a proposed model“. Thesis, University of Bradford, 2007. http://hdl.handle.net/10454/4193.
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KM is the process of creating value from the intangible assets of an enterprise. It deals
with how best to leverage knowledge internally in the enterprise (in its individual
employees, and the knowledge that gets built into its structures and systems) and
externally to the customers and stakeholders. As KM initiatives, projects and systems
are just beginning to appear in organisations, there is little research and empirical field
data to guide the successful development and implementation of such systems or to
guide the expectations of the potential benefits of such systems. In addition, about 84
per cent of KM programmes failed or exerted no significant impact on the adopting
organisations worldwide due to inability to consider many critical factors that contribute
to the success of KM project implementation.
Hence, this study is an exploratory investigation into the KM implementation based on
an integrated approach. This includes: (1) a comprehensive review of the relevant
literature; (2) a comprehensive analysis of secondary case studies of KM
implementations in 90 organisations presented in the literature, in order to arrive at the
most critical factors of KM implementation and their degree of criticality; (3)
exploratory global survey of 92 organisations in 23 countries that have already
implemented or are in the process of implementing KM; (4) in-depth case studies of
four leading organisations to understand how KM implementation processes and the
critical factors identified are being addressed.
Based on the empirical findings of the study, 28 critical factors were identified that must
be carefully considered in the KM implementation to achieve a successful project.
Moreover, the study proposes an integrated model for effective KM implementation
which contains essential elements that contribute to project success.Government of Saudi Arabia represented by King Saud University.
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Koschitzki, Kim Christine Cornelia [Verfasser], und Franz [Gutachter] Jakob. „Evaluation of preclinical animal models in bone tissue engineering and their success in clinical translation / Kim Christine Cornelia Koschitzki ; Gutachter: Franz Jakob“. Würzburg : Universität Würzburg, 2020. http://d-nb.info/121459400X/34.
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22
Saal, Kim Ann [Verfasser], Paul [Akademischer Betreuer] Lingor, Mathias [Akademischer Betreuer] Bähr und Martin [Akademischer Betreuer] Göpfert. „Modulation of the ROCK pathway in models of Parkinson´s disease / Kim Ann Saal. Betreuer: Paul Lingor. Gutachter: Mathias Bähr ; Martin Göpfert“. Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1080030387/34.
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23
Matos, Zarsoza José Ignacio. „Modelo de Respuesta Aleatorizada Mixto de Kim y Warde: aplicación a estudiantes de la Facultad de Ciencias Matemáticas de la UNMSM – 2015“. Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/5508.
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Estudia el Modelo de Respuesta Aleatorizada Mixto (MRAM) propuesto por Kim y Warde (2004), el cual se aplicó en una encuesta realizada en la Facultad de Ciencias Matemáticas, para investigar el comportamiento de los jóvenes estudiantes con respecto a las malas prácticas académicas, realizar copias y consumo de drogas para mejorar el rendimiento académico en un examen. La población estudiada comprende a los alumnos matriculados en el Semestre 2015-I pertenecientes a las cuatro escuelas académico profesionales de la Facultad de Ciencias Matemáticas de la UNMSM.Tesis
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Leschka, Stephan. „Entwurfsmethoden und Leistungsgrenzen elektromechanischer Schallquellen für Ultraschallanwendungen in Gasen im Frequenzbereich um 100 kHz“. Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1134573918125-13603.
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Air-borne ultrasonic transducers are optimised to achieve a maximal sound pressure in a frequency range around 100 kHz. Moreover, the radiation of a high acoustic power is desired, which requires a large transducer area. Within this dissertation the ultrasonic transducers are, therefore, optimised to operate in the resonance mode. Using this operating point the maximal force is fed into the transducer while it is charged with the lowest loss possible. Many applications of air-borne ultrasound need a sufficient bandwidth in addition to a high sound pressure, that s why the swinging mass of the transducer has to be minimised. For these reasons, air-borne capacitive and piezoelectric film transducers take centre stage of these examinations. New network models of the stripe membrane and the pre-stressed stripe plate are derived to optimise these ultrasonic transducers. Besides its mechanical tension and its bending stiffness, the new network model of the pre-stressed and pressure loaded stripe plate takes also the stiffness caused by the shape of the plate into account. The examined transducers achive a maximal piston velocity around 1 m/sUltraschallwandler für Anwendungen in Luft werden zur Bereitstellung eines maximalen Schalldrucks im Frequenzbereich um 100 kHz optimiert. Sie sollen außerdem die Abstrahlung einer großen Schallleistung zulassen, was eine große Wandlerfläche voraussetzt. Deshalb werden in dieser Arbeit die Ultraschallsender für den Resonanzbetrieb optimiert, wo man die maximale Krafteinspeisung bei minimalen Verlusten einstellt. Viele Anwendungen von Ultraschall in Luft benötigen neben einem hohen Schalldruckpegel auch eine ausreichende Bandbreite, wozu die schwingende Masse der Wandler zu minimieren ist. Deshalb stehen kapazitive und piezoelektrische Folienwandler im Resonanzbetrieb im Vordergrund der Untersuchungen. Zur Optimierung dieser Ultraschallsender werden die Netzwerkmodelle der Streifenmembran und der gespannten Streifenplatte abgeleitet. Neben der mechanischen Spannung und der Biegesteifigkeit berücksichtigt das Netzwerkmodell der gespannten und statisch druckbelasteten Streifenplatte die Formversteifung. Die untersuchten Wandler erreichen eine maximale Kolbenschnelle um 1 m/s
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Kim, Youngsun [Verfasser], und John [Akademischer Betreuer] Tenhunen. „Estimation and mitigation assessment of N2O emission and nitrate leaching in a mountainous catchment in South Korea using the LandscapeDNDC model / Youngsun Kim. Betreuer: John Tenhunen“. Bayreuth : Universität Bayreuth, 2015. http://d-nb.info/1068860499/34.
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26
Leschka, Stephan. „Entwurfsmethoden und Leistungsgrenzen elektromechanischer Schallquellen für Ultraschallanwendungen in Gasen im Frequenzbereich um 100 kHz“. Doctoral thesis, Technische Universität Dresden, 2003. https://tud.qucosa.de/id/qucosa%3A24606.
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Air-borne ultrasonic transducers are optimised to achieve a maximal sound pressure in a frequency range around 100 kHz. Moreover, the radiation of a high acoustic power is desired, which requires a large transducer area. Within this dissertation the ultrasonic transducers are, therefore, optimised to operate in the resonance mode. Using this operating point the maximal force is fed into the transducer while it is charged with the lowest loss possible. Many applications of air-borne ultrasound need a sufficient bandwidth in addition to a high sound pressure, that s why the swinging mass of the transducer has to be minimised. For these reasons, air-borne capacitive and piezoelectric film transducers take centre stage of these examinations. New network models of the stripe membrane and the pre-stressed stripe plate are derived to optimise these ultrasonic transducers. Besides its mechanical tension and its bending stiffness, the new network model of the pre-stressed and pressure loaded stripe plate takes also the stiffness caused by the shape of the plate into account. The examined transducers achive a maximal piston velocity around 1 m/s.Ultraschallwandler für Anwendungen in Luft werden zur Bereitstellung eines maximalen Schalldrucks im Frequenzbereich um 100 kHz optimiert. Sie sollen außerdem die Abstrahlung einer großen Schallleistung zulassen, was eine große Wandlerfläche voraussetzt. Deshalb werden in dieser Arbeit die Ultraschallsender für den Resonanzbetrieb optimiert, wo man die maximale Krafteinspeisung bei minimalen Verlusten einstellt. Viele Anwendungen von Ultraschall in Luft benötigen neben einem hohen Schalldruckpegel auch eine ausreichende Bandbreite, wozu die schwingende Masse der Wandler zu minimieren ist. Deshalb stehen kapazitive und piezoelektrische Folienwandler im Resonanzbetrieb im Vordergrund der Untersuchungen. Zur Optimierung dieser Ultraschallsender werden die Netzwerkmodelle der Streifenmembran und der gespannten Streifenplatte abgeleitet. Neben der mechanischen Spannung und der Biegesteifigkeit berücksichtigt das Netzwerkmodell der gespannten und statisch druckbelasteten Streifenplatte die Formversteifung. Die untersuchten Wandler erreichen eine maximale Kolbenschnelle um 1 m/s.
27
Alsadhan, Abdulaziz Omar Abdullah. „The implementation of knowledge management systems : an empirical study of critical success factors and a proposed model“. Thesis, University of Bradford, 2007. http://hdl.handle.net/10454/4193.
Der volle Inhalt der QuelleAnnotation:
KM is the process of creating value from the intangible assets of an enterprise. It deals with how best to leverage knowledge internally in the enterprise (in its individual employees, and the knowledge that gets built into its structures and systems) and externally to the customers and stakeholders. As KM initiatives, projects and systems are just beginning to appear in organisations, there is little research and empirical field data to guide the successful development and implementation of such systems or to guide the expectations of the potential benefits of such systems. In addition, about 84 per cent of KM programmes failed or exerted no significant impact on the adopting organisations worldwide due to inability to consider many critical factors that contribute to the success of KM project implementation. Hence, this study is an exploratory investigation into the KM implementation based on an integrated approach. This includes: (1) a comprehensive review of the relevant literature; (2) a comprehensive analysis of secondary case studies of KM implementations in 90 organisations presented in the literature, in order to arrive at the most critical factors of KM implementation and their degree of criticality; (3) exploratory global survey of 92 organisations in 23 countries that have already implemented or are in the process of implementing KM; (4) in-depth case studies of four leading organisations to understand how KM implementation processes and the critical factors identified are being addressed. Based on the empirical findings of the study, 28 critical factors were identified that must be carefully considered in the KM implementation to achieve a successful project. Moreover, the study proposes an integrated model for effective KM implementation which contains essential elements that contribute to project success.
28
Tonelli, Luan [Verfasser], und Liana [Akademischer Betreuer] Melo-Thomas. „A new animal model of paradoxical kinesia induced by 50-kHz ultrasonic vocalizations playback in rats: implications of the inferior colliculus / Luan Tonelli ; Betreuer: Liana Melo-Thomas“. Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/1166314081/34.
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Kuchta, Marek. „Viability of the Premium Airline Business Model - Analysis of business class-only services offered by Eos Airlines, MAXjet Airways and Lufthansa, Swiss, KLM in cooperation with PrivatAir Herausgeber: die“. Institut für Transportwirtschaft und Logistik, WU Vienna University of Economics and Business, 2007. http://epub.wu.ac.at/752/1/document.pdf.
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Between 2002 and 2005, Lufthansa, Swiss and KLM in cooperation with PrivatAir, start-up airlines Eos and MAXjet individually, launched scheduled business class-only services between Europe and the US. This paper qualitatively analyses the new business model from the strategic and operational point of view. Different approaches based on pull or push motivation have been identified and the characteristics of the service offerings extensively examined. From the strategic aspect, the analysis has proven that the products have an inherent value benefit for the respective target group. It has been established that short and ultra-long haul routes are not viable for the business model. The main shortcoming of the offering is the lack of connectivity as opposed to network carriers, resulting in dependency on the local demand. For the start-up airlines, establishment of market presence and goodwill is critical. In the area of operating economics, pilot crew and navigation charges have a higher impact than in the mixed class operation. Airport charges and administrative overhead build a larger portion of total expenses in case of traditional airline services. No significant evidence against the viability of the premium airline model could be found. (author's abstract)Series: Schriftenreihe des Instituts für Transportwirtschaft und Logistik - Verkehr
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Bussmann, André Roberto. „Efeitos da L-arginina na proteção renal por meio da dosagem plasmática e urinária de biomarcadores e histologia estudo em modelo experimental de lesão de isquemia e reperfusão em ratos sob anestesia inalatória /“. Botucatu, 2016. http://hdl.handle.net/11449/144710.
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Orientador: Norma Sueli Pinheiro ModoloResumo: Justificativa: Durante lesão de isquemia e reperfusão renal ocorre a inativação de óxido nítrico (NO), essa inativação diminui o relaxamento arterial endotélio-dependente e independente. O aumento nos níveis de NO poderia melhorar a disfunção endotelial e o relaxamento arterial diminuindo a lesão renal. O NO, sintetizado a partir da L-arginina pela enzima óxido nítrico sintase (NOS), parece exercer um efeito protetor sobre os rins durante a lesão de isquemia/reperfusão (I/R). O objetivo do estudo foi avaliar o efeito da L-arginina nos níveis dos biomarcadores de lesão (NGALp, NGALu, KIM-1 e IL-18) na função e na histopatologia renal em ratos submetidos a lesão de I/R.Métodos: 32 ratos Wistar foram randomizados em 4 grupos: Sham (S): Laparotomia e nefrectomia direita. Controle (C): Laparotomia e nefrectomia direita, I/R em rim esquerdo. Controle L-arginina (CLA): Laparotomia e nefrectomia direita, L-arginina na dose de 800mg.kg-1.dose-1, 24 e 1 hora antes. L-arginina (LA): Laparotomia e nefrectomia direita, I/R em rim esquerdo, L-arginina na dose de 800mg.kg-1.dose-1, 24 e 1 hora antes. Foram analisados os níveis de NGALp, NGALu, KIM-1 e IL-18, creatinina e histopatologia renal. Nível de significância: p<0,05.Resultados: Creatinina aumenta em todos os grupos com LA≈C>S≈CLA. A NGALp, aumenta em todos os grupos com evolução semelhante. A NGALu foi maior no grupo C e CLA em relação ao grupo LA e apresentou valores intermediários no grupo S. Os níveis de KIM-1 aumentam nos gru... (Resumo completo, clicar acesso eletrônico abaixo)
Doutor
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Bussmann, André Roberto [UNESP]. „Efeitos da L-arginina na proteção renal por meio da dosagem plasmática e urinária de biomarcadores e histologia: estudo em modelo experimental de lesão de isquemia e reperfusão em ratos sob anestesia inalatória“. Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/144710.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Justificativa: Durante lesão de isquemia e reperfusão renal ocorre a inativação de óxido nítrico (NO), essa inativação diminui o relaxamento arterial endotélio-dependente e independente. O aumento nos níveis de NO poderia melhorar a disfunção endotelial e o relaxamento arterial diminuindo a lesão renal. O NO, sintetizado a partir da L-arginina pela enzima óxido nítrico sintase (NOS), parece exercer um efeito protetor sobre os rins durante a lesão de isquemia/reperfusão (I/R). O objetivo do estudo foi avaliar o efeito da L-arginina nos níveis dos biomarcadores de lesão (NGALp, NGALu, KIM-1 e IL-18) na função e na histopatologia renal em ratos submetidos a lesão de I/R. Métodos: 32 ratos Wistar foram randomizados em 4 grupos: Sham (S): Laparotomia e nefrectomia direita. Controle (C): Laparotomia e nefrectomia direita, I/R em rim esquerdo. Controle L-arginina (CLA): Laparotomia e nefrectomia direita, L-arginina na dose de 800mg.kg-1.dose-1, 24 e 1 hora antes. L-arginina (LA): Laparotomia e nefrectomia direita, I/R em rim esquerdo, L-arginina na dose de 800mg.kg-1.dose-1, 24 e 1 hora antes. Foram analisados os níveis de NGALp, NGALu, KIM-1 e IL-18, creatinina e histopatologia renal. Nível de significância: p<0,05. Resultados: Creatinina aumenta em todos os grupos com LA≈C>S≈CLA. A NGALp, aumenta em todos os grupos com evolução semelhante. A NGALu foi maior no grupo C e CLA em relação ao grupo LA e apresentou valores intermediários no grupo S. Os níveis de KIM-1 aumentam nos grupos S, CLA e LA, porém na análise de contrastes não há diferença na evolução dos grupos. A IL-18 apresentou valores maiores no grupo LA comparado aos demais grupos (C, S e CLA). Os grupos C e LA apresentaram grau de lesão no lado esquerdo maior que os grupos S e CLA. Não existe diferença histopatológica entre C e LA e nem entre S e CLA. Conclusão: A L-arginina não exerce efeito protetor ou danoso aos rins submetidos a lesão de I/R na avaliação da função, da histopatologia renal e dos níveis de NGALp, KIM-1
Background: Nitric oxide (NO) inactivation occurs during renal ischaemia/reperfusion injury. This inactivation decreases endothelium-dependent and -independent arterial relaxation. Higher NO levels can improve endothelial dysfunction and arterial relaxation, thereby reducing the level of kidney injury. NO, synthesized from L-arginine by the enzyme nitric oxide synthase (NOS), seems to exerts a protective effect on the kidneys during tissue ischemia-reperfusion injury. The objective of this study was to evaluate the effect of L-arginine on the levels of injury biomarkers (pNGAL, uNGAL, KIM-1 e IL-18) for kidney function and histology in rats subjected ischaemiareperfusion injury. Methods: Thirty-two Wistar rats were randomised into the following 4 groups: Sham (S), laparotomy and right nephrectomy; Control (C), laparotomy and right nephrectomy and left kidney I/R; L-arginine control (LAC), laparotomy and right nephrectomy and L-arginine at a dose of 800 mg.kg-1 .dose-1 , 24 hours and 1 hour before surgery; and L-arginine (LA), laparotomy and right nephrectomy, left kidney I/R, and L-arginine at a dose of 800 mg.kg -1 .dose-1 , 24 hours and 1 hour before surgery. The pNGAL, uNGAL, KIM-1 e IL-18 and creatinine levels and kidney histopathology were analysed. The significance level was p < 0.05. Results: Creatinine was increased in all groups, with LA≈C>S≈LAC. pNGAL was increased in all groups and showed a similar trend. uNGAL levels were higher in groups C and LAC than LA and had intermediate values in group S. The KIM-1 levels were increased in the S, LAC and LA groups, but the contrast analysis revealed no differences between the groups in terms of their trends. IL-18 levels were higher in LA than in the other groups (C, S and LAC). The C and LA groups, compared with the S and LAC groups, had higher damage on the left side. There was no histopathological difference between C and LA or between S and LAC. Conclusion: L-arginine does not exert a damaging or protective effect on kidneys undergoing I/R injury based on the evaluation of kidney functions, histopathology and pNGAL and KIM-1 levels.
FAPESP: 2012/13603-2
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Alazmi, Mutiran A. „An empirical study of IT based knowledge management systems implementation : a comparative study with the Kuwait and the UK public sectors and proposed model for best practice knowledge management“. Thesis, University of Bradford, 2003. http://hdl.handle.net/10454/3728.
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Knowledge Management (KM) helps extend the knowledge of individuals or groups across organisations in ways that directly affect performance. Further, it is a formalised and integrated approach to identify and manage an organisation's knowledge assets. The study is an exploratory investigation of the implementation of IT-based Knowledge Management Systems. It is also a comparative study of the Kuwait and UK public sectors with the specific aim of building a best practice model for KM implementation in conjunction with IT. This includes examination of the relevant literature, a comprehensive analysis of case studies of KM implementation in 91 organisations presented in the literature, in order to arrive at the most critical factors of KM implementation and their degree of criticality, and an exploratory survey of 68 organisations both in the UK and Kuwait relating to their experiences in implementing initiatives such as KM and the role of IT in that process. In view of the intensive and extensive data for interdependence relationships between variables, statistical techniques were used, and in-depth studies of 16 leading organisations, to understand how the KM implementation processes and the critical factors identified were addressed and implemented. This study identifies critical factors of success in KM domain that applicable to Kuwaiti organisations. These factors were categorised under four different headings: (1) Technology, (2) KM processes, (3) Change management, (4) Top management commitment. A generic holistic model for effective KM implementation is proposed.
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Nguyen, Thuan L. „Assessing Knowledge Management Values by Using Intellectual Capital to Measure Organizational Performance“. NSUWorks, 2016. http://nsuworks.nova.edu/gscis_etd/986.
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Measuring knowledge management performance was one of, if not the most challenging knowledge management activities. This study suggested using intellectual capital as a proxy for knowledge management performance in evaluating its impact on organizational performance. The Value Added Intellectual Coefficient model was employed to measure intellectual capital. Although being used widely in research, the model had its limitations. Also, for intellectual capital measurement, there was a lack of guidelines supported by empirical evidence or best practices. The present study aimed to test the classic and a modified version of this model, and based on the results, shed light on whether the classic version was good enough or the modified one should be highly recommended. The financial fundamental and market data of 425 randomly selected publicly listed firms were collected, and the structural equation modeling technique was employed to test the models. Chi-square difference test was performed to determine whether there was a statistically significant difference between these two models. The results of the tests indicated that the difference between them was insignificant. Therefore, it was concluded that the classic model is adequate, and it can be used effectively to measure intellectual capital. Adding two new efficiency elements – research and development efficiency and relational capital efficiency – in the model did not provide any significant benefit.
34
Dremont, Nicolas. „Maturity integrated in a meta model of knowledge to help decision making in preliminary collaborative design of mechanical systems“. Phd thesis, Université de Technologie de Compiègne, 2013. http://tel.archives-ouvertes.fr/tel-01002393.
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The design of mechanical systems, due to their multi-disciplinary and technological aspects, involves different people who, together, work and make decisions and jointly participate in the development of the product. They work in a collaborative manner; however, they may have different strategies, geographical positions, cultures and do not know the other members of the team. Preliminary design represents the early stages of the design cycle or product definition. A number of uncertainties regarding the parameters and product information are very important. There is an important lack of knowledge at this stage of the design process that must be managed or filled in order to improve and support the decision making in the early phases. It is this lack of knowledge that I propose to qualify and characterise, providing an answer to the question: how does one to take into account the lack of knowledge in decision making during the preliminary design collaboration? To do so, we propose a meta-model for structuring product information and knowledge by integrating product maturity. A metric allows this maturity to be defined, to identify the level of knowledge of the product designers and to guide the decision making, thanks to the use of a qualitative and quantitative approach. Finally, we evaluate the ability of the meta-model to generate the different models produced and its relevance to the implementation in an industrial case.
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Monaghan, Sean J. „Approaches to DIVA vaccination for fish using infectious salmon anaemia and koi herpesvirus disease as models“. Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/17261.
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The expanding aquaculture industry continues to encounter major challenges in the form of highly contagious aquatic viruses. Control and eradication measures targeting the most lethal and economically damaging virus-induced diseases, some of which are notifiable, currently involve ‘stamping out’ policies and surveillance strategies. These approaches to disease control are performed through mass-culling followed by restriction in the movement of fish and fish products, resulting in considerable impacts on trade. Although effective, these expensive, ethically complex measures threaten the sustainability and reputation of the aquatic food sector, and could possibly be reduced by emulating innovative vaccination strategies that have proved pivotal in maintaining the success of the terrestrial livestock industry. DIVA ‘differentiating infected from vaccinated animal’ strategies provide a basis to vaccinate and contain disease outbreaks without compromising ‘disease-free’ status, as antibodies induced specifically to infection can be distinguished from those induced in vaccinated animals. Various approaches were carried out in this study to assess the feasibility of marker/DIVA vaccination for two of the most important disease threats to the global Atlantic salmon and common carp/koi industries, i.e. infectious salmon anaemia (ISA) and koi herpesvirus disease (KHVD), respectively. Antibody responses of Atlantic salmon (Salmo salar L.), following immunisation with an ISA vaccine, administered with foreign immunogenic marker antigens (tetanus toxoid (TT), fluorescein isothiocyanate (FITC) and keyhole limpet hemocyanin (KLH)) were assessed by antigen-specific enzyme linked immunosorbent assay (ELISA). Although antibodies were induced to some markers, these were unreliable and may have been affected by temperature and smoltification. Detectable antibodies to ISAV antigen were also largely inconsistent despite low serum dilutions of 1/20 being employed for serological analysis. The poor antibody responses of salmon to the inactivated ISA vaccine suggested that DIVA vaccination is not feasible for ISA. A similar approach for KHV, utilising green fluorescent protein (GFP) as the marker, similarly failed to induce sufficiently detectable antibody responses in vaccinated carp (Cyprinus carpio L.). However, as high anti-KHV antibody titres were obtained with an inactivated KHV vaccine (≥1/3200), alternative approaches were carried out to assess the feasibility of DIVA vaccination for carp. Investigations of early KHV pathogenesis in vivo and antigen expression kinetics in vitro (0-10 days post infection (dpi)) provided valuable data for the diagnostics necessary for DIVA surveillance strategies. Following viral infection, molecular methods were shown to be the most effective approach for early detection of KHV infected fish prior to sero-conversion, during which time antibodies are not detectable. An experimental immersion challenge with KHV, however, revealed complications in molecular detection during early infection. The KHV DNA was detected in external biopsies of skin and gills, but also internally in gut and peripheral blood leukocytes ≤ 6 hours post infection (hpi), suggesting rapid virus uptake by the host. The gills and gut appeared to be possible portals of entry, supported by detection of DNA in cells by in situ hybridisation (ISH). However, many false negative results using organ biopsies occurred during the first 4 dpi. The gills were the most reliable lethal biopsy for KHV detection by various polymerase chain reaction (PCR) assays, with a PCR targeting a glycoprotein-gene (ORF56) and a real-time PCR assay being the most sensitive of the 7 methods investigated. Importantly, non-lethal mucus samples reduced the number of false negative results obtained by all KHV PCR assays during the earliest infection stages with large levels of viral DNA being detected in mucus (up to 80,000 KHV DNA genomic equivalents 200 μL-1). KHV DNA was consistently detected in the mucus as a consequence of virus being shed from the skin. Determining the expression kinetics of different viral structural proteins can be useful for DIVA serological tests. Analysis of KHV antigen expression in tissues by immunohistochemistry and indirect fluorescent antibody test was inconclusive, therefore 2 novel semi-quantitative immunofluorescence techniques were developed for determining KHV antigen expression kinetics in susceptible cell lines. During the course of KHV infection in vitro, a greater abundance of capsid antigen was produced in infected cells compared to a glycoprotein antigen (ORF56), as determined by detection with antigen-specific monoclonal antibodies (MAbs). The capsid antigen was characterised as a ~100 kDa protein by SDS-PAGE and identified as a product of KHV ORF84 by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF/TOF MS). This antigen was subsequently detected in the serum of >25% of KHV infected/exposed carp (6/17), as well as in carp vaccinated with a live attenuated vaccine (3/4), but not with an inactivated vaccine (0/7), by Western blot making it a potential DIVA target for an inactivated vaccine. Attempts were made to improve the sensitivity of KHV serological testing by taking advantage of recombinant proteins specific for KHV (CyHV-3), rORF62 and rORF68 and eliminating any interference by cross-reacting antibodies to carp pox (CyHV-1). These proteins successfully reacted with anti-KHV antibodies. The feasibility of DIVA strategies for KHVD was determined using these recombinant antigens to coat ELISA plates. Differential antibody responses were detected from carp sera to an internal virus tegument protein (rORF62) and external region of a transmembrane protein (rORF68). Fish vaccinated with an inactivated vaccine produced significantly lower antibody responses to rORF62 than to rORF68, whereas infected, exposed and live attenuated vaccinated fish recognised both proteins allowing differentiation between vaccinated and infected carp. However, the sensitivity of the assay was limited, possibly by high levels of natural antibodies detected at the relatively low serum dilutions (1/200) used. As the capsid antigen (ORF84) and tegument protein (ORF62) are derived from internal KHV structural proteins, they induce non-neutralising antibodies, which may be useful for DIVA strategies. Such antibodies are longer lasting than neutralising antibodies and often comprise the majority of fish anti-viral antibodies. This was noted in a fish surviving experimental challenge, which had an antibody titre of 1/10,000, but neutralising titre of 1/45. Such antigens may therefore hold potential for developing effective serological diagnostic tests for KHV and provide the potential for DIVA strategies against KHVD. Natural antibodies will, however, continue to present a challenge to the development of sensitive and reliable KHV serological tests, and hence the application of DIVA strategies.
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Tran, Minh Tung. „Fabrication du logement planifié sous forme de "KDTM" (Khu Đô Thị Mới) à Hanoï : la ville de quartiers ou/et la ville de projets ?“ Thesis, Toulouse 2, 2014. http://www.theses.fr/2014TOU20113/document.
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Cette recherche est destinée à analyser principalement les KDTM* qui représentent actuellement les nouvelles zones résidentielles de Hanoi et sont aussi un des éléments contemporains très importants de la fabrication du logement planifié en particulier et de la (re)structuration spatiale de Hanoi en général sous les impacts de la tendance de globalisation, de métropolisation et l’ « explosion » urbaine dans le monde. 4 phases (féodale - coloniale - indépendante - ouverte) de l’évolution spatiale de Hanoi sont résumées pour retirer les images caractéristiques de chaque phase de l’urbanisation qui réfléchissent les métamorphoses internes d’une ville orientale millénaire sous les mouvements historiques et les impacts externes : le conflit pour le développement. Les changements stratégiques de planification spatiale dans le schéma directeur actuel (de 2011) par rapport aux schémas directeurs précédents (de 1961, 1976, 1981, 1992 et 1998) concernent le contexte spécifique (géo-historique - géo-politique - géo-social - géo-économique) de Hanoi en transition lorsque les modes de (re)faire la ville en projet deviennent de plus en plus répandus. En répondant à la question de la réalité du logement (planifié), Hanoi montre ses objectifs attachés à la fabrication des typologies différentes de logement sous les impacts socio-économiques et les (nouvelles) idées de planification spatiale. Le mécanisme, le processus de l’apparition et de la création de la modalité de KDTM sont faits référence à ceux de l’autre modalité d’habitat planifié (KTT**) pour trouver les différences réglementaires et pratiques entre ces 2 modalités. Cette recherche choisit et présente la situation de 4 cas d’études en établissant les systèmes des critères de la classification et en montrant la diversité des choix des KDTM typiques à faire un panorama des KDTM à Hanoi. A travers ces 4 KDTM typiques choisies, les rôles, les dynamiques, les modes d’exploitation et les buts d’argent et de profit des acteurs dans la fabrication d’un projet de KDTM sont abordés sur la base des analyses des affaires et des activités financières et économiques. Puis, le fondement et la nature des projets de KDTM sont retrouvés pour (re)confirmer leurs rôles, leurs démarches et pour chercher les outils efficaces, les dimensions attachées et le renouvellement de conception basés sur les modes actuels à organiser et gérer les projets de logement planifié dans la ville. En outre, les KDTM sont également approchées sous l’angle des relations sociales entre les sections spatiales d’une KDTM, entre les KDTM les unes et les autres, et entre les KDTM et les quartiers voisins existants en fonction du fonctionnement gestionnaire et la démarche d’après-projet des KDTM devenues les vrais quartiers de la ville. Enfin, l’imagination pour le futur des villes nouvelles et des espaces urbanisés de Hanoi est inclue dans cette recherche. * KDTM - « Khu Đô Thị Mới » en vietnamien : ce sont les « nouvelles zones résiden-tielles » qui étaient fabriquées sous forme de projet dans les villes vietnamiennes de-puis des années 90 du XXe siècle sur les principes de l’économie de marché. ** KTT - « Khu Tập Thể » en vietnamien : ce sont les « ensembles d’habitation collec-tive » qui ont été fabriqués dans les villes vietnamiennes (du Nord) des années 60 aux années 80 du XXe siècle sur les principes de l’économie de subvention budgétaireThis research is aimed to analyze KDTM* which is considered as the typical repre-sentative of new residential areas in Hanoi and also a very important contemporary factor of the implementation of centrally planned housing projects in particular and the (re)structure of Hanoi’s space in general under the effects of globalization, metropolization and the « explosion » of urban areas on the world. Four phases (feu-dal - colonial - independent - open) of the development of Hanoi’s space are summa-rized to show the typical image of each phase of urbanization, reflecting the internal movement of the 1000-year-old city of the Orient with the change of the history and external affects: conflict for development. The strategic changes in urban planning in the current master plan (in 2011) compared to the previous ones (in 1961, 1976, 1981, 1992, and 1998) are related to the specific background (geo-history - geo-politics - geo-society - geo-economy) of Hanoi in transition when modes of (re)making city by projects are becoming more common. By settling many (planned) housing is-sues, Hanoi shows its intentions are integrated into producing different types of housing under the influence of socio-economic factors and (new) space planning ideas. The differences in the regulation theory and reality between KDTM entity and another collective housing entity (KTT**) are identified by comparing their appearing mechanism and process as well as production. The research also focuses on studying and choosing the circumstances of 4 sample cases, setting the classification criteria and showing the diversity in sample selection to capture a panorama of KDTM in Ha-noi. By the 4 selected samples, the function, activeness, exploring methods, economic aims and the profits of all factors related to the manufacture of a KDTM project are also mentioned in the study based on the analyzation of businesses, financial and economic activities. Additionally, the study also refers to the foundation and nature of KDTM projects in order to (re)confirm their roles and movements to seek for effective tools, suitable elements and new designing conception based on the organization and management of current planned housing projects of the city. Moreover, the KDTM are also analyzed in the social connection between internal space elements of a KDTM project, between KDTM, and between KDTM and intangible residential areas moving in accordance with changes and management operation in KDTM post-project stages to become proper new urban residential areas. Finally, the imagination of the future of new urban areas and urbanized spaces of Hanoi are also mentioned in this research. * KDTM - « Khu Đô Thị Mới » in vietnamese, is the acronym of « new urban areas » which are new residential areas formed under the implementation of many plans in some cities of Vietnam since the 90s of the 20th century according to the principles of the market economy. ** KTT - « Khu Tập Thể » in vietnamese, is the acronym of « collective housing estates » which are apartment blocks constructed in many (Northern) cities of Vietnam since the 60s to the 80s of the 20th century according to the principles of the centrally planned economy
Nghiên cứu này chủ yếu nhằm mục đích phân tích các KDTM* được xem là đại diện cho các khu dân cư mới của Hà Nội và là một trong những yếu tố đương đại rất quan trọng của quá trình sản xuất nhà ở kế hoạch hoá nói riêng và (tái) cấu trúc không gian Hà Nội nói chung dưới ảnh hưởng của xu hướng toàn cầu hoá, siêu đô thị hoá và sự « bùng nổ » đô thị trên thế giới. 4 giai đoạn (phong kiến - thuộc địa - độc lập - mở cửa) của sự tiến triển không gian Hà Nội được tóm tắt lại nhằm rút ra hình ảnh đặc trưng của mỗi giai đoạn đô thị hoá phản ánh các biến đổi nội tại của một đô thị phương Đông nghìn năm tuổi dưới những vận động lịch sử và những tác động ngoại lai : mâu thuẫn để phát triển. Những thay đổi chiến lược về hoạch định không gian trong bản đồ quy hoạch tổng thể hiện tại (năm 2011) so với các bản đồ quy hoạch tổng thể trước đó (các năm 1961, 1976, 1981, 1992 và 1998) liên quan đến bối cảnh đặc thù (địa lịch sử - địa chính trị - địa xã hội - địa kinh tế) của một Hà Nội đang trong thời kỳ quá độ khi mà các cách thức kiến tạo (lại) thành phố bằng các dự án ngày càng trở nên phổ biến. Với việc giải quyết các vấn đề về nhà ở (kế hoạch hoá), Hà Nội cho thấy những mục đích của mình được lồng ghép vào việc sản xuất các loại hình nhà ở khác nhau dưới những tác động kinh tế - xã hội và các ý tưởng (mới) về hoạch định không gian. Cơ chế, quy trình xuất hiện và tạo ra thể thức KDTM được đối chiếu với một thể thức cư trú tập thể khác (KTT**) để tìm thấy được sự khác nhau về quy định và thực tế giữa 2 thể thức này. Nghiên cứu này cũng lựa chọn và giới thiệu tình huống của 4 mẫu nghiên cứu, đồng thời lập nên hệ thống các tiêu chí phân loại và chỉ ra tính đa dạng trong việc lựa chọn nhằm mang đến một bức tranh toàn cảnh về các KDTM ở Hà Nội. Thông qua 4 KDTM điển hình được lựa chọn, vai trò, tính năng động, cách thức khai thác và mục đính kinh tế cũng như lợi nhuận của các nhân tố liên quan đến quá trình tạo ra một dự án KDTM được đề cập trên cơ sở các phân tích về các thương vụ, các hoạt động tài chính và kinh tế. Tiếp theo, cơ sở nền tảng và bản chất của các dự án KDTM cũng được gợi lại nhằm khẳng định (lại) vai trò và sự vận động của chúng, nhằm tìm kiếm những công cụ hữu hiệu, những yếu tố tích hợp và sự đổi mới quan niệm thiết kế dựa trên các cách thức tổ chức và quản lý các dự án nhà ở kế hoạch hoá hiện tại của thành phố. Ngoài ra, các KDTM cũng được phân tích dưới góc độ quan hệ xã hội giữa các thành phần không gian bên trong một KDTM, giữa các KDTM với nhau và giữa các KDTM với các khu dân cư láng giềng hiện hữu chuyển biến theo sự vận động và vận hành quản lý giai đoạn hậu dự án của các KDTM để trở thành những khu dân cư thực sự của đô thị. Cuối cùng, những hình dung về tương lai của các khu dân cư mới cũng như các không gian đô thị hoá của Hà Nội cũng được đề cập đến trong nghiên cứu này. * KDTM - viết tắt của « Khu Đô Thị Mới », là những « khu dân cư mới » được xây dựng dưới hình thức các dự án tại các thành phố của Việt Nam kể từ những năm 90 thế kỷ XX theo các nguyên tắc của nền kinh tế thị trường. ** KTT - viết tắt của « Khu Tập Thể », là những « khu nhà ở tập thể » được xây dựng tại các thành phố (miền Bắc) của Việt Nam từ những năm 60 đến những năm 80 thế kỷ XX theo các nguyên tắc của nền kinh tế tập trung bao cấp
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Santibáñez, Daniel Gustavo San Martín. „Mineração de interesses no processo de modernização dirigida a arquitetura“. Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/549.
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Previous issue date: 2013-08-27Universidade Federal de Sao Carlos
Software systems are considered legacy when they were developed many years ago with outdated technologies and their maintenance process consumes a large amount of resources. One cause of these problems is the inadequate modularization of its crosscutting concerns. In this situation, an alternative is to modernize the system with a new language to provide better support for concern modularization. ADM (Architecture-Driven Modernization) is an OMG model-driven proposal to modernize legacy systems and consist of a set of metamodels in which the main metamodel is KDM (Knowledge Discovery Metamodel), which allows to represent all the characteristics of a system. The modernization process begins with reverse engineering to represent the legacy system in a KDM model. Thereafter, refactorings can be applied to the model and then generate the modernized code. However, the current proposals do not support crosscutting concerns modularization. This occurs because the first step is to identify the elements which contribute with the implementation of a particular concern and it is not supplied by ADM. In this sense, this dissertation presents an approach for mining crosscutting concerns in KDM models, thus establishing the first step towards to a Concern-Driven modernization. The approach is a combination of two techniques, a concern library and a modified K-means clustering algorithm, which comprises four steps where the input is a KDM model and the result is the same KDM model with annotated concerns and some log files. In addition, we developed an Eclipse plugin called CCKDM to implement the approach. An evaluation was performed involving three software systems. The results show that for systems using APIs to implement their concerns the developed technique is an effective method for identifying them, achieving good values of precision and recall.
Sistemas de software são considerados legados quando foram desenvolvidos há muitos anos com tecnologias obsoletas e seu processo de manutenção consome uma quantidade de recursos além da desejada. Uma das causas desses problemas é a modularização inadequada de seus interesses transversais. Quando se encontram nessa situação, uma alternativa é modernizar o sistema para novas linguagens que forneçam melhor suporte à modularização desse tipo de interesse. A ADM (Architecture-Driven Modernization) é uma proposta do OMG para a modernização orientada a modelos de sistemas legados, sendo composta por um conjunto de metamodelos, em que o principal é o KDM (Knowledge Discovery Metamodel), que permite representar todas as particularidades de um sistema. O processo de modernização inicia-se com a engenharia reversa, em que o sistema legado é inteiramente representado em KDM. Depois disso, pode-se aplicar refatorações nesse modelo e gerar o código modernizado. Entretanto, a proposta atual da ADM não inclui suporte para modularizar interesses transversais de um sistema. Isso ocorre porque o primeiro passo desse processo é minerar e encontrar os elementos que contribuem para a implementação de um dado interesse, e isso não é fornecido pela ADM. Nesse sentido, nesta dissertação é apresentada uma abordagem para mineração de interesses no metamodelo KDM, estabelecendo o primeiro passo para um processo de modernização dirigido a interesses. A abordagem de mineração proposta atua com uma combinação de duas técnicas; uma biblioteca de interesses e um algoritmo modificado K-means para agrupar strings similares. A abordagem inclui quatro passos onde a entrada é um modelo KDM e o resultado é o mesmo modelo KDM com os interesses anotados e mais alguns arquivos de registro. Além disso, desenvolveuse um plugin chamado CCKDM para o ambiente Eclipse que implementa a abordagem. Uma avaliação foi realizada envolvendo três sistemas de software. Os resultados da avaliação mostraram que para sistemas que utilizam APIs para implementar seus interesses a técnica desenvolvida é efetiva para a identificação deles, atingindo bons valores de precisão e cobertura.
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Nelson, Karen. „A multi-methodological examination of Information and Knowledge Management (IKM) in business contexts“. Queensland University of Technology, 2004. http://eprints.qut.edu.au/15930/.
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Many different approaches have been proposed with the aim of facilitating sound and successful information management (IM) and knowledge management (KM) practices within business contexts. These approaches seek to identify organizational factors (e.g. culture or information technology practices) or to suggest management processes (e.g. human resources management) required to establish environments conducive to IM and KM. Most of these approaches, often presented as frameworks (as they are referred to in this study) for organizational IM or KM, are exemplified by the following features.Firstly, they have emerged as unrelated notions, with little reference to each other or to foundational studies in the area. Secondly these frameworks are not based on any
theoretical foundation. Thirdly, these frameworks have tended to focus on either
information or knowledge management activities but not both, even though organizational IM and KM exist in a complementary and co-dependent relationship.
The usefulness of these frameworks is made problematic by muddled use of the terms
'information', 'knowledge', 'IM' and 'KM', which are often transposed or used synonymously. The situation is further complicated by the inherent complexity of the organizational environments into which practitioners attempt to introduce information and knowledge management (IKM) initiatives.
Early outputs of this research are explanations of how the terminology above is used in
this study and a literature review that describes current IM and KM frameworks by
analyzing their components. The literature review identifies current challenges in the
research domain, including the need for sound foundation (referent model) on which future IKM frameworks can be based. A suitable referent model is proposed by integrating single and double feedback loops (from systems theory) with two concepts from the IM literature: IM processes and the domains of IM activity.
Then, an interpretive multi-methodological research (MMR) approach is pursued consisting of three sequential phases: action research, transition and case study. The first phase, a 3-cycle action research project accompanied by a longitudinal descriptive case study and an embedded literature analysis, was conducted over a 31 month period. The key research outcome of the action research phase was a set of candidate enablers Information and Knowledge Management (IKM) in Business Contexts for organizational IKM, while the organizational deliverables included policies, strategies, process improvement and new information systems. The information gathered in phase one was rich and deep. However, in keeping with the goal of the research to produce a practical, useful IKM framework, the researcher sought a broader view from the IKM community. To achieve this practitioner view, a second research phase was designed to bridge the gap between the detailed examinations of IKM initiatives within one
organizational environment, to the examination of IKM initiatives within other organizations. Therefore phase two - a transition phase - consisted of a series of surveys and interviews with IKM practitioners that explored their perceptions of organizational IKM activities and environments. The data collected in phase two
supported the findings from phase one and informed the development of the case protocols for the third - case study - phase. In the third phase, six IKM projects in three organizations were studied. Documentary and interview data were examined to understand the relationships between IKM projects, the candidate enablers identified earlier in phases one and two, and other organizational factors implicated in IKM
initiatives. When analyzed, the findings from the third phase converged with the data
collected in the previous two phases, and provided a rich, deep and broad collection of
material.
The study culminates by synthesizing the data collected in the three research phases to
(1) confirm a suitable referent model on which IKM frameworks can be based and (2) develop an integrated, multidimensional IKM framework that assimilates the referent model. The referent model, which is based on previous calls for IKM frameworks to have a sound theoretical foundation, incorporates two established concepts from the IKM literature: (a) the operational, analytical and strategic domains of IKM activity and (b) double and single loop feedback loops of systems thinking applied to IKM processes. The practical and flexible IKM framework, which assimilates these concepts, has three dimensions. These dimensions are (i) domains of IKM activity and feedback loops (ii)
organizational enablers (iii) project context. It is envisaged that this framework be used
by practitioners to identify and manage areas of the business environment that require
attention to ensure success of IKM projects or initiatives.
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Herencsár, Norbert. „Nové aktivní funkční bloky a jejich aplikace v kmitočtových filtrech a kvadraturních oscilátorech“. Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-233510.
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Kmitočtové filtry a sinusoidní oscilátory jsou lineární elektronické obvody, které jsou používány v široké oblasti elektroniky a jsou základními stavebními bloky v analogovém zpracování signálu. V poslední dekádě pro tento účel bylo prezentováno velké množství stavebních funkčních bloků. V letech 2000 a 2006 na Ústavu telekomunikací, VUT v Brně byly definovány univerzální proudový konvejor (UCC) a univerzální napět'ový konvejor (UVC) a vyrobeny ve spolupráci s firmou AMI Semiconductor Czech, Ltd. Ovšem, stále existuje požadavek na vývoj nových aktivních prvků, které nabízejí nové výhody. Hlavní přínos práce proto spočívá v definici dalších původních aktivních stavebních bloků jako jsou differential-input buffered and transconductance amplifier (DBTA), current follower transconductance amplifier (CFTA), z-copy current-controlled current inverting transconductance amplifier (ZC-CCCITA), generalized current follower differential input transconductance amplifier (GCFDITA), voltage gain-controlled modified current-feedback operational amplifier (VGC-MCFOA), a minus-type current-controlled third-generation voltage conveyor (CC-VCIII-). Pomocí navržených aktivních stavebních bloků byly prezentovány původní zapojení fázovacích článků prvního řádu, univerzální filtry druhého řádu, ekvivalenty obvodu typu KHN, inverzní filtry, aktivní simulátory uzemněného induktoru a kvadraturní sinusoidní oscilátory pracující v proudovém, napět'ovém a smíšeném módu. Chování navržených obvodů byla ověřena simulací v prostředí SPICE a ve vybraných případech experimentálním měřením.
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Paulke, Jan. „Optimal Combination of Reduction Methods in Structural Mechanics and Selection of a Suitable Intermediate Dimension“. Master's thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-150318.
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A two-step model order reduction method is investigated in order to overcome problems of certain one-step methods. Not only optimal combinations of one-step reductions are considered but also the selection of a suitable intermediate dimension (ID) is described. Several automated selection methods are presented and their application tested on a gear box model. The implementation is realized using a Matlab-based Software MORPACK. Several recommendations are given towards the selection of a suitable ID, and problems in Model Order Reduction (MOR) combinations are pointed out. A pseudo two-step is suggested to reduce the full system without any modal information. A new node selection approach is proposed to enhance the SEREP approximation of the system’s response for small reduced representationsMehrschrittverfahren der Modellreduktion werden untersucht, um spezielle Probleme konventioneller Einschrittverfahren zu lösen. Eine optimale Kombination von strukturmechanischen Reduktionsverfahren und die Auswahl einer geeigneten Zwischendimension wird untersucht. Dafür werden automatische Verfahren in Matlab implementiert, in die Software MORPACK integriert und anhand des Finite Elemente Modells eines Getriebegehäuses ausgewertet. Zur Auswahl der Zwischendimension werden Empfehlungen genannt und auf Probleme bei der Kombinationen bestimmter Reduktionsverfahren hingewiesen. Ein Pseudo- Zweischrittverfahren wird vorgestellt, welches eine Reduktion ohne Kenntnis der modalen Größen bei ähnlicher Genauigkeit im Vergleich zu modalen Unterraumverfahren durchführt. Für kleine Reduktionsdimensionen wird ein Knotenauswahlverfahren vorgeschlagen, um die Approximation des Frequenzganges durch die System Equivalent Reduction Expansion Process (SEREP)-Reduktion zu verbessern
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Jayawickrama, Uchitha. „Knowledge management competence for ERP implementation success“. Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/3498.
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The global business environment has changed dramatically in recent years, as competition in complex knowledge-based economies has increased. Enterprise Resource Planning (ERP) systems have been viewed as a way to manage increased business complexity, leading to the rapid adoption and implementation of such systems, as ERP can support enterprises to improve their competitiveness. Knowledge management (KM) is crucial for ERP systems implementation, however a highly demanding task. Therefore, the primary concern of this research is to examine the effectiveness of knowledge management activities that would contribute to achieve ERP implementation success. This study adopted mixed methods approach by combining semi-structured interviews and a questionnaire to collect empirical data from ERP professionals in both manufacturing and service sector organisations. In the qualitative phase, it develops the “framework of integrative knowledge” based on empirical evidence, that can improve KM competence for ERP implementation success. Data analysis has been undertaken using a combination of thematic analysis and comparative analysis with respect to 14 ERP implementations in the UK. The framework integrates multiple perspectives in terms of knowledge components to enhance KM competence, including knowledge types, knowledge layers, KM lifecycle and knowledge determinants. It discovered 19 knowledge determinants to drive knowledge management activities during ERP projects, which is another vital contribution to the existing knowledge. Furthermore, the study develops the “knowledge network model” for ERP implementations in order to facilitate the knowledge flows between various stakeholders involved in ERP implementations, which can help to understand the interactions between the knowledge components. Moreover, sub-knowledge types (knowledge elements) under each knowledge type were discovered through empirical evidence. The quantitative phase was adopted to extend the findings of the qualitative phase. The knowledge types and knowledge elements were prioritised using Analytic Hierarchy Process (AHP) method through an online AHP based questionnaire with 77 responses from ERP professionals involved in UK ERP implementations. Furthermore, knowledge prioritisation demonstrates how effectively the framework of integrative knowledge can be used during ERP implementations with the help of prioritised knowledge. In total 4 knowledge types and 21 knowledge elements were ranked based on their contribution to achieve ERP success; four variables of information quality, systems quality, individual impact and organisational impact were used to measure ERP success. This study has number of theoretical contributions including framework of integrative knowledge, knowledge network model for ERP implementations and ERP knowledge prioritisation. Moreover, the framework of integrative knowledge can provide ERP practitioners with useful guidance on what the key knowledge determinants are and how the relationships between knowledge components should be best managed to achieve ERP implementation success in business reality.
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Pieczonka, Tino. „Untersuchung und Visualisierung von Gletschervolumenänderungen im Tarim-Einzugsgebiet, Zentralasien, unter Verwendung multi-temporaler digitaler Geländemodelle“. Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-234998.
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Das aride Tarim-Becken im Nordwesten Chinas unterliegt Umweltveränderungen, die durch rapide Ausbreitung bewässerter Landwirtschaft sowie Klimawandel angetrieben sind. Während im Oberlauf in den letzten 50 Jahren ein Abflussanstieg beobachtet wurde, haben landwirtschaftliche Aktivitäten im Mittel- und Unterlauf zur Wasserknappheit und der drastischen Verkürzung des endorheischen Flusses geführt. Der Abfluss des Tarim, dessen Hauptzufluss der in Kirgistan entspringende Aksu-Fluss darstellt, wird zu einem großen Teil aus Schnee- und Gletscherschmelze in den oberen Gebirgseinzugsgebieten des Tien Shan gespeist. Da die Unterlieger von dem Wasser des Tarim zur Bewässerung in der Landwirtschaft abhängig sind, sind das Wissen über den Beitrag der Gletscherschmelze zum Abfluss sowie das Wissen über mögliche zukünftige Änderungen der Gletschermasse von großer Relevanz.
Zahlreiche Studien beschränken sich oftmals nur auf die Betrachtung der Gletscherfläche, deren Änderung jedoch keine direkten Rückschlüsse auf etwaige Massenänderungen zulässt und zudem nur ein indirektes Signal für Klimaänderungen darstellt. Weiterführende Studien, welche zusätzlich Gletschermassenänderungen im Aksu-Einzugsgebiet untersuchen, haben häufig nur lokalen Charakter. Regionale Studien zu Massenänderungen, welche ganze Einzugsgebiete und Gebirgsketten umfassen, finden sich mehrheitlich für die letzte Dekade durch die Verfügbarkeit laseraltimetrischer Höhendaten und gravimetrischer Messungen, wobei letztere durch hohe Unsicherheiten gekennzeichnet sind. Um jedoch Aussagen hinsichtlich der zeitlichen Entwicklung der Gletscher treffen zu können, widmet sich die Arbeit insbesondere der Untersuchung von Gletschermassenveränderungen seit den 1970er Jahren unter Verwendung deklassifizierter amerikanischer Satellitenbilddaten, SRTM-Daten sowie SPOT-5-Stereodaten.
Zur Ableitung geodätischer Gletschermassenbilanzen wurden Daten der Mapping Camera (MC) des Hexagon-Satelliten aus den Jahren 1973–1976 stereoskopisch ausgewertet und mit Daten der SRTM-Mission aus dem Jahr 2000 und SPOT-5-Stereodaten aus dem Jahr 2009 verglichen. Die Ableitung geodätischer Massenbilanzen aus multi-temporalen Geländemodellen erforderte deren Co-Registrierung auf das als SRTM gewählte Master-Modell. In einem zweistufigen Verfahren wurden Verkippungen über eine globale Trendfläche und horizontale Lagefehler über eine analytische Beziehung zwischen Oberflächenneigung, Orientierung und der entsprechenden Höhendifferenz unter Einbeziehung nicht-glazialer Pixel minimiert. Die Eindringtiefe des SRTM-C-Bands wurde mittels ICESat-Daten mit 2,2 m abgeschätzt und bei der Differenzbildung berücksichtigt. Zur Bereinigung der Differenzbilder zwischen den Geländemodellen wurde ein höhenbasierter Ansatz entwickelt, welcher eine abnehmende Varianz der Höhendifferenzwerte vom Ablations- zum Akkumulationsgebiet annimmt. Dieser Ansatz stellt eine deutlich realistischere Annahme im Vergleich zur oftmals verwendeten Nullannahme dar, welche von keinen Veränderungen in den Akkumulationsgebieten ausgeht. Die Gletscher im Aksu-Einzugsgebiet zeigten im Ergebnis einen Massenverlust von 0,35±0,34 m w.e./a im Zeitraum 1975–1999, was dem globalen Durchschnitt für diese Periode entspricht. In den Jahren 1999 bis 2009 wurde indes eine Abnahme des Massenverlusts (0,23±0,19 m w.e./a) festgestellt, was möglicherweise auf eine Zunahme des Niederschlags in der letzten Dekade zurückzuführen ist. Zudem zeigte sich, dass schuttbedeckte Gletscher, deren Schuttauflage ab einer Dicke von etwa 2 cm einen hemmenden Einfluss auf die Abschmelzrate hat, signifikant an Masse verloren haben bei gleichzeitig nur relativ geringer Flächenabnahme. Insgesamt wies die räumliche Verteilung der Massenänderungen eine starke Heterogenität auf, mit zunehmender Tendenz von Osten nach Westen und von den Innen- zu den Außenbereichen des Zentralen Tien Shan. Zusätzlich konnten zahlreiche, zuvor in der Literatur nicht benannte, surgende Gletscher identifiziert werden. Der durch Eismassenverlust induzierte Anteil am Gesamtabfluss des Aksu wurde im Ergebnis mit circa 20% ermittelt.
Neben der Oberflächenneigung sind, in einfachen Modellen zur Eisdickenabschätzung, die basale Scherspannung und der Anteil basalen Gleitens an der Oberflächengeschwindigkeit Haupteinflussfaktoren. Anhand gemessener Eisdicken, fernerkundlich abgeleiteter Gletscherfließgeschwindigkeiten und der Oberflächenneigung, als Näherung der Neigung des Gletscherbetts, konnte ein empirischer Zusammenhang zur Abschätzung des Anteils basalen Gleitens abgeleitet werden. Die Eisdickenabschätzung für die vier größten Gletscher des Zentralen Tien Shan erfolgte im weiteren Verlauf durch Anwendung von Glen’s Fließgesetz, unter Annahme laminaren Fließens. Die Ergebnisse weisen für die betrachteten Gletscher mittlere Dicken von 70 m bis 140 m für deren schuttbedeckte Gletscherzungen auf. Diese Werte liegen teilweise deutlich unter denen bisheriger Studien, welche von einer globalen Scherspannung für den gesamten Gletscher oder einem konstanten Anteil basalen Gleitens ausgehen. Im Vergleich zu vorhandenen Eisdickenmessungen konnte durch die lokale Abschätzung der basalen Geschwindigkeit die mittlere Abweichung von zuvor mehr als 200 m auf etwa 50 m reduziert werden. Durch Einbeziehung der in der Arbeit ermittelten geodätischen Gletschermassenbilanzen wurde der relative Volumenverlust seit den 1970er Jahren mit 6% bis 28% quantifiziert, welcher deutlich unter dem schuttfreier Gletscher innerhalb Hochasiens liegt.
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Shaktour, Mahmoud. „Nekonvenční obvodové prvky pro návrh příčkových filtrů“. Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-233531.
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Kmitočtové filtry jsou lineární elektrické obvody, které jsou využívány v různých oblastech elektroniky. Současně tvoří základní stavební bloky pro analogové zpracování signálů. V poslední dekádě bylo zavedeno množství aktivních stavebních bloků pro analogové zpracování signálů. Stále však existuje potřeba vývoje nových aktivních součástek, které by poskytovaly nové možnosti a lepší parametry. V práci jsou diskutovány různé aspekty obvodů pracujících v napěťovém, proudovém a smíšném módu. Práce reaguje na dnešní potřebu nízkovýkonových a nízkonapěťových aplikací pro přenosné přístroje a mobilní komunikační systémy a na problémy jejich návrhu. Potřeba těchto výkonných nízkonapěťových zařízení je výzvou návrhářů k hledání nových obvodových topologií a nových nízkonapěťových technik. V práci je popsána řada aktivních prvků, jako například operační transkonduktanční zesilovač (OTA), proudový konvejor II. generace (CCII) a CDTA (Current Differencing Transconductance Amplifier). Dále jsou navrženy nové prvky, jako jsou VDTA (Voltage Differencing Transconductance Amplifier) a VDVTA (Voltage Differencing Voltage Transconductance Amplifier). Všechny tyto prvky byly rovněž implementovány pomocí "bulk-driven" techniky CMOS s cílem realizace nízkonapěťových aplikací. Tato práce je rovněž zaměřena na náhrady klasických induktorů syntetickými induktory v pasivních LC příčkových filtrech. Tyto náhrady pak mohou vést k syntéze aktivních filtrů se zajímavými vlastnostmi.
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Šimeček, Josef. „Inference v Bayesovských sítích“. Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-236341.
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This master's thesis deals with demonstration of various approaches to probabilistic inference in Bayesian networks. Basics of probability theory, introduction to Bayesian networks, methods for Bayesian inference and applications of Bayesian networks are described in theoretical part. Inference techniques are explained and complemented by their algorithm. Techniques are also illustrated on example. Practical part contains implementation description, experiments with demonstration applications and conclusion of the results.
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Sjögren, Erik. „Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation“. Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132571.
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The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. Disposition is the expression used to encapsulate both elimination and distribution. This thesis presents novel approaches and models based on simple in vitro systems for the investigation of processes involved in the hepatic drug disposition. An approach to the estimation of enzyme kinetics based on substrate depletion data from cell fractions was thoroughly evaluated through experiments and simulations. The results that it provided were confirmed to be accurate and robust. In addition, a new experimental setup suitable for a screening environment, i.e., for a reduced number of samples, was generated through optimal experimental design. The optimization suggested that sampling at late time points over a wide range of concentration was the most advantageous. A model, based on data from primary hepatocytes in suspension, for the investigation of cellular disposition of metabolized drugs was developed. Information on the relative importance of metabolism and membrane protein related distribution was obtained by analysis of changes in the kinetics by specific inhibition of the various processes. The model was evaluated by comparing the results to those obtained from an in vivo study analyzed with an especially constructed mechanistic PBPK model. These investigations showed that the suggested model produced good predictions of the relative importance of metabolism and carrier mediated membrane transport for hepatic disposition. In conclusion, new approaches for the investigation of processes involved in hepatic disposition were developed. These methods were shown to be robust and increased the output of information from already commonly implemented in vitro systems.
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Jeřábek, Jan. „Kmitočtové filtry s proudovými aktivními prvky“. Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-233528.
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This doctoral thesis is focused mainly on research of new current active elements and their applications in frequency filters suitable for current-mode. Work is focused on design of new filtering structures suitable for traditional single-ended signal processing and also on structures suitable for fully-differential applications. The thesis contains three designed general conceptions of KHN-type second-order filters. Adjustability of quality factor and pole frequency is provided by controllable current amplifiers that are placed properly in designed structures. Structures also contain second-generation current conveyors, multiple-output current followers, transconductance amplifiers and their fully-differential equivalents. There are lot of possible solutions that could be obtained from general structures, some of them are presented in the work. The thesis also presents several multifunctional and also single-purpose filtering structures of second-order and two variants of n-th order synthetic elements which are suitable to realize higher order filters both in single ended and fully differential type. In each case, functionality of new solutions is verified by simulations and in several cases also by real measurement.
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Saaidia, Noureddine. „Sur les familles des lois de fonction de hasard unimodale : applications en fiabilité et analyse de survie“. Thesis, Bordeaux 1, 2013. http://www.theses.fr/2013BOR14794/document.
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En fiabilité et en analyse de survie, les distributions qui ont une fonction de hasard unimodale ne sont pas nombreuses, qu'on peut citer: Gaussienne inverse ,log-normale, log-logistique, de Birnbaum-Saunders, de Weibull exponentielle et de Weibullgénéralisée. Dans cette thèse, nous développons les tests modifiés du Chi-deux pour ces distributions tout en comparant la distribution Gaussienne inverse avec les autres. Ensuite nousconstruisons le modèle AFT basé sur la distribution Gaussienne inverse et les systèmes redondants basés sur les distributions de fonction de hasard unimodaleIn reliability and survival analysis, distributions that have a unimodalor $\cap-$shape hazard rate function are not too many, they include: the inverse Gaussian,log-normal, log-logistic, Birnbaum-Saunders, exponential Weibull and power generalized Weibulldistributions. In this thesis, we develop the modified Chi-squared tests for these distributions,and we give a comparative study between the inverse Gaussian distribution and the otherdistributions, then we realize simulations. We also construct the AFT model based on the inverseGaussian distribution and redundant systems based on distributions having a unimodal hazard ratefunction
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Van, Hoi Le. „Health for community dwelling older people : trends, inequalities, needs and care in rural Vietnam“. Doctoral thesis, Umeå universitet, Epidemiologi och global hälsa, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47467.
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Background InVietnam, the proportion of people aged 60 and above has increased rapidly in recent decades. The majority live in rural areas where socioeconomic status is more disadvantaged than in urban areas.Vietnam’s economic status is improving but disparities in income and living conditions are widening between groups and regions. A consistent and emerging danger of communicable diseases and an increase of non-communicable diseases exist concurrently. The emigration of young people and the impact of other socioeconomic changes leave more elderly on their own and with less family support. Introduction of user fees and development of a private sector improve the coverage and quality of health care but increase household health expenditures and inequalities in health care. Life expectancy at birth has increased, but not much is known about changes during old age. There is a lack of evidence, particularly in rural settings, about health-related quality of life (HRQoL) among older people within the context of socioeconomic changes and health-sector reform. Knowledge of long-term elderly care needs in the community and the relevant models are still limited. To provide evidence for developing new policies and models of care, this thesis aimed to assess general health status, health care needs, and perspectives on future health care options for community-dwelling older people. Methods An abridged life table was used to estimate cohort life expectancies at old age from longitudinal data collected by FilaBavi DSS during 1999-2006. This covered 7,668 people aged 60 and above with 43,272 person-years. A 2007 cross-sectional survey was conducted among people aged 60 and over living in 2,240 households that were randomly selected from the FilaBavi DSS. Interviews used a structured questionnaire to assess HRQoL, daily care needs, and willingness to use and to pay for models of care. Participant and household socioeconomic characteristics were extracted from the 2007 DSS re-census. Differences in life expectancy are examined by socioeconomic factors. The EQ-5D index is calculated based on the time trade-off tariff. Distributions of study subjects by study variables are described with 95% confidence intervals. Multivariate analyses are performed to identify socioeconomic determinants of HRQoL, need of support, ADL index, and willingness to use and pay for models of care. In addition, four focus group discussions with the elderly, their household members, and community association representatives were conducted to explore perspectives on the use of services by applying content analysis. Results Life expectancy at age 60 increased by approximately one year from 1999-2002 to 2003-2006, but tended to decrease in the most vulnerable groups. There is a wide gap in life expectancy by poverty status and living arrangement. The sex gap in life expectancy is consistent across all socioeconomic groups and is wider among the more disadvantaged populations. The EQ-5D index at old age is 0.876. Younger age groups, position as household head, working, literacy, and belonging to better wealth quintiles are determinants of higher HRQoL. Ageing has a primary influence on HRQoL that is mainly due to reduction in physical (rather than mental) functions. Being a household head and working at old age are advantageous for attaining better HRQoL in physical rather than psychological terms. Economic conditions affect HRQoL through sensory rather than physical functions. Long-term living conditions are more likely to affect HRQoL than short-term economic conditions. Dependence in instrumental or intellectual activities of daily living (ADLs) is more common than in basic ADLs. People who need complete help are fewer than those who need some help in almost all ADLs. Over two-fifths of people who needed help received enough support in all ADL dimensions. Children and grand-children are confirmed to be the main caregivers. Presence of chronic illness, age groups, sex, educational level, marital status, household membership, working status, household size, living arrangement, residential area, household wealth, and poverty status are determinants of the need for care. Use of mobile teams is the most requested service; the fewest respondents intend to use a nursing centre. Households expect to use services for their elderly to a greater extent than did the elderly themselves. Willingness to use services decreases when potential fees increase. The proportion of respondents who require free services is 2 to 3 times higher than those willing to pay full cost. Households are willing to pay more for day care and nursing centres than are the elderly. The elderly are more willing to pay for mobile teams than are their households. ADL index, age group, sex, literacy, marital status, living arrangement, head of household status, living area, working status, poverty and household wealth are factors related to willingness to use services. Conclusions There is a trend of increasing life expectancy at older ages in ruralVietnam. Inequalities in life expectancy exist between socioeconomic groups. HRQoL at old age is at a high level, but varies substantially according to socioeconomic factors. An unmet need of daily care for older people remains. Family is the main source of support for care. Need for care is in more demand among disadvantaged groups. Development of a social network for community-based long-term elderly care is needed. The network should focus on instrumental and intellectual ADLs rather than basic ADLs. Home-based care is more essential than institutionalized care. Community-based elderly care will be used and partly paid for if it is provided by the government or associations. The determinants of elderly health and care needs should be addressed by appropriate social and health policies with greater targeting of the poorest and most disadvantaged groups. Building capacity for health professionals and informal caregivers, as well as support for the most vulnerable elderly groups, is essential for providing and assessing the services.Aging and Living Conditions Program
Vietnam-Sweden Collaborative Program in Health, SIDA/Sarec
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Kondorová, Lenka. „Kam směřuje česká politika duševního zdraví?“ Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-358462.
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This thesis deals with the Czech and international ideas applied in the "Strategy of Reform of Psychiatric Care" issued in 2013 by the Ministry of Health of the Czech Republic. The main starting point of this work is the fact that the care of people with mental illness in Czech and international environment is oriented on the biological treatment of the patient with psycho- pharmaceuticals and that there is a deficit in the area of psychosocial treatment. International and Czech mental health policy seeks to promote a bio-psycho-social approach to patient's care. However, current psychiatry continues to be involved in conducting clinical research focused on the efficiency of psycho-pharmaceuticals. These studies are driven and sponsored mainly by the pharmaceutical industry. But international and Czech policies are still not able to adequately reflect this situation within the field of psychiatry. The Czech Republic has not so far paid attention to mental health issues and has lagged behind the other developed countries in this area. The empirical part of this work is divided into two parts. The first part of the research focuses on the Czech and international ideas applied in the "Strategy of Reform of Psychiatric Care" issued in 2013 by Ministry of Health. The methods used here are - content...
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Maciejewski, James Michael. „An application of KAM theory to a model for particle channelling in crystals and some related numerical simulations“. Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-05-1092.
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It has been seen in physical experiments as early as the 1960’s that when a positively charged particle is injected into a crystal in certain directions and with sufficiently
high energy, the particle can penetrate into the crystalline structure to a depth which is
unexpectedly long. Such motions in the crystal are referred to as channelling trajectories.
Herein, we consider a Hamiltonian model for particle motion in a crystal. We then proceed
to show that the results of KAM theory are applicable to the model, and moreover that these
result predict the existence of trajectories for the fired particle which do indeed penetrate
the crystal deeply. Finally, we present the results of two series of numerical simulations
which strongly suggest that this behaviour is observable in our model.text