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Thematische Bibliographien / Microfluidic circuit / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Microfluidic circuit“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 1. Februar 2022

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1

Babikian, Sarkis, Brian Soriano, G. P. Li und Mark Bachman. „Laminate Materials for Microfluidic PCBs“. International Symposium on Microelectronics 2012, Nr. 1 (01.01.2012): 000162–68. http://dx.doi.org/10.4071/isom-2012-ta54.

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The printed circuit board (PCB) is a very attractive platform to produce highly integrated highly functional microfluidic devices. We have investigated laminate materials and developed novel fabrication processes to realize low cost and scalable to manufacturing integrated microfluidics on PCBs. In this paper we describe our vision to integrate functional components with microfluidic channels. We also report on the use of Ethylene Vinyl Acetate (EVA) as a laminate for microfluidics. The material was characterized for microfluidic applications and compared with our previously reported laminates: 1002F and Polyurethane.

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2

Paegel, Brian M., William H. Grover, Alison M. Skelley, Richard A. Mathies und Gerald F. Joyce. „Microfluidic Serial Dilution Circuit“. Analytical Chemistry 78, Nr. 21 (November 2006): 7522–27. http://dx.doi.org/10.1021/ac0608265.

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3

Swank, Zoe, und Sebastian J. Maerkl. „CFPU: A Cell-Free Processing Unit for High-Throughput, Automated In Vitro Circuit Characterization in Steady-State Conditions“. BioDesign Research 2021 (17.03.2021): 1–11. http://dx.doi.org/10.34133/2021/2968181.

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Forward engineering synthetic circuits are at the core of synthetic biology. Automated solutions will be required to facilitate circuit design and implementation. Circuit design is increasingly being automated with design software, but innovations in experimental automation are lagging behind. Microfluidic technologies made it possible to perform in vitro transcription-translation (tx-tl) reactions with increasing throughput and sophistication, enabling screening and characterization of individual circuit elements and complete circuit designs. Here, we developed an automated microfluidic cell-free processing unit (CFPU) that extends high-throughput screening capabilities to a steady-state reaction environment, which is essential for the implementation and analysis of more complex and dynamic circuits. The CFPU contains 280 chemostats that can be individually programmed with DNA circuits. Each chemostat is periodically supplied with tx-tl reagents, giving rise to sustained, long-term steady-state conditions. Using microfluidic pulse width modulation (PWM), the device is able to generate tx-tl reagent compositions in real time. The device has higher throughput, lower reagent consumption, and overall higher functionality than current chemostat devices. We applied this technology to map transcription factor-based repression under equilibrium conditions and implemented dynamic gene circuits switchable by small molecules. We expect the CFPU to help bridge the gap between circuit design and experimental automation for in vitro development of synthetic gene circuits.

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4

Wang, Dai-Hua, Lian-Kai Tang, Yun-Hao Peng und Huai-Qiang Yu. „Principle and structure of a printed circuit board process–based piezoelectric microfluidic pump integrated into printed circuit board“. Journal of Intelligent Material Systems and Structures 30, Nr. 17 (30.08.2019): 2595–604. http://dx.doi.org/10.1177/1045389x19869519.

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Considering mature printed circuit board processes, researches on microfluidic pumps that can be integrated into printed circuit board will provide a solution for further miniaturization and integration of microfluidic systems with low costs. The principle and structure of a printed circuit board process–based piezoelectric microfluidic pump integrated into printed circuit board are proposed and realized in this article. The printed circuit board process–based design and manufacturing technology of a piezoelectric microfluidic pump integrated into printed circuit board is researched utilizing printed circuit board as a platform. The flow characteristics of the fabricated microfluidic pump are experimentally tested. The research results show that the proposed principle and structure of the piezoelectric microfluidic pump can be fabricated utilizing mature printed circuit board process with advantages of simple structure and convenient processing. The fabricated printed circuit board process–based microfluidic pump can linearly pump in and pump out fluid with self-injection. Moreover, the flow rate and back pressure can be controlled by changing the peak-to-peak value, frequency, and phase difference of the driving voltages. The instantaneous flow rate has the pulsation property consistent with the drive voltage frequency. The proposed principle and structure are beneficial to integrate the fabricated printed circuit board process–based microfluidic pump with other microfluidic components to realize complicated microfluidic systems on printed circuit board.

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Stojanović, Paroški, Samardžić, Radovanović und Krstić. „Microfluidics-Based Four Fundamental Electronic Circuit Elements Resistor, Inductor, Capacitor and Memristor“. Electronics 8, Nr. 9 (29.08.2019): 960. http://dx.doi.org/10.3390/electronics8090960.

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The microfluidics domain has been progressing rapidly recently, particularly considering its useful applications in the field of biomedicine. This paper presents a novel, microfluidics-based design for four fundamental circuit elements in electronics, namely resistor, inductor, capacitor, and memristor. These widely used passive components were fabricated using a precise and cost-effective xurography technique, which enables the construction of multi-layered structures on foil, with gold used as a conductive material. To complete their assembly, an appropriate fluid was injected into the microfluidic channel of each component: the resistor, inductor, capacitor, and memristor were charged with transformer oil, ferrofluid, NaCl solution, and TiO2 solution, respectively. The electrical performance of these components was determined using an Impedance Analyzer and Keithley 2410 High-Voltage Source Meter instrument and the observed characteristics are promising for a wide range of applications in the field of microfluidic electronics.

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Dong, Liangwei, und Yueli Hu. „Microfluidic networks embedded in a printed circuit board“. Modern Physics Letters B 31, Nr. 19-21 (27.07.2017): 1740017. http://dx.doi.org/10.1142/s0217984917400176.

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In order to improve the robustness of microfluidic networks in printed circuit board (PCB)-based microfluidic platforms, a new method was presented. A pattern in a PCB was formed using hollowed-out technology. Polydimethylsiloxane was partly filled in the hollowed-out fields after mounting an adhesive tape on the bottom of the PCB, and solidified in an oven. Then, microfluidic networks were built using soft lithography technology. Microfluidic transportation and dilution operations were demonstrated using the fabricated microfluidic platform. Results show that this method can embed microfluidic networks into a PCB, and microfluidic operations can be implemented in the microfluidic networks embedded into the PCB.

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7

Na, Sangcheol, Myeongwoo Kang, Seokyoung Bang, Daehun Park, Jinhyun Kim, Sang Jun Sim, Sunghoe Chang und Noo Li Jeon. „Microfluidic neural axon diode“. TECHNOLOGY 04, Nr. 04 (Dezember 2016): 240–48. http://dx.doi.org/10.1142/s2339547816500102.

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Neural circuits, groups of neurons connected in directional manner, play a central role in information processing. Advances in neuronal biology research is limited by a lack of appropriate in vitro methods to construct and probe neuronal networks. Here, we describe a microfluidic culture platform that directs the growth of axons using “neural diode” structures to control neural connectivity. This platform is compatible with live cell imaging and can be used to (i) form pre-synaptic and postsynaptic neurons by directional axon growth and (ii) localize physical and chemical treatment to pre- or postsynaptic neuron groups (i.e. virus infection and etc.). The “neural diode” design consist of a microchannel that split into two branches: one is directed straight toward while the other returns back toward the starting point in a closed loop to send the axons back to the origin. We optimized the “neural diode” pattern dimension and design to achieve close to 70% directionality with a single unit of the “diode”. When repeated 3 times, near perfect (98–100% at wide range of cell concentrations) directionality can be achieved. The living neural circuit was characterized using Ca imaging and confirmed their function. The platform also serves as a straightforward, reproducible method to recapitulate a variety of neural circuit in vitro that were previously observable only in brain slice or in vivo models. The microfluidic neural diode may lead to better models for understanding the neural circuit and neurodegenerative diseases.

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8

Zhao, San Ping. „A Pressure Sensor with Electrical Readout Based on IL Electrofluidic Circuit“. Applied Mechanics and Materials 66-68 (Juli 2011): 1936–41. http://dx.doi.org/10.4028/www.scientific.net/amm.66-68.1936.

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This paper presents a novel pressure sensor based on IL electrofluidic circuit. The simple configuration makes the device capable of being seamlessly integrated to wide varieties of PDMS microfluidic devices. The experimental results demonstrate that IL-filled microfluidic channels can be utilized as electrical resistors to construct functional circuits, and an electrofluidic Wheatstone bridge circuit has been designed to construct the pressure sensor. In the pressure sensor performance characterization, the calibration results show that the gate voltage is linear proportional to the applied pressure with sensitivity of 8.45 mV/psi and the pressure as small as 2.5 psi can be easily detected.

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9

Wang, Shaoxi, Yue Yin und Xiaoya Fan. „The Chip Cooling Model and Route Optimization with Digital Microfluidics“. Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University 37, Nr. 1 (Februar 2019): 107–13. http://dx.doi.org/10.1051/jnwpu/20193710107.

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Using microfluidic technology to achieve integrated chip cooling is becoming a promising method to extend Moore law effective period. The thermal management is always critical for 3D integrated circuit design. Hot spots due to spatially non-uniform heat flux in integrated circuits can cause physical stress that further reduces reliability. The critical point for chip cooling is to use microfluidic cooling accurately on the hot spots. First, based on electro-wetting on dielectric, the paper presents an adaptive chip cooling technique using the digital microfluidics. Then, a two-plans 3D chip cooling model has been given with its working principle and characteristics. And single plan chip cooling model is presented, including its capacitance performance and models. Moreover, the dentate electrode is designed to achieve droplet continuing movement. Next, the ant colony optimization is adopted to get optimal route during electrode moving. Last, the experiments demonstrate the adaptive chip cooling technique proposed in this paper is effective and efficiency.

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10

Cartas-Ayala, Marco A., Mohamed Raafat und Rohit Karnik. „Microfluidic Circuits: Self-Sorting of Deformable Particles in an Asynchronous Logic Microfluidic Circuit (Small 3/2013)“. Small 9, Nr. 3 (01.02.2013): 333. http://dx.doi.org/10.1002/smll.201370015.

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11

Lundy, Terence. „Advanced Confocal Microscopy An Essential Technique for Microfluidics Development“. Microscopy Today 14, Nr. 1 (Januar 2006): 8–13. http://dx.doi.org/10.1017/s1551929500055127.

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Many believe that microfluidics has the potential to do for chemistry and biology what the integrated circuit has done for electronics — integrating tremendously complex chemical and biological processes into simple easy-to-use devices that will eventually pervade our lives. While microfluidics has made great progress in the last decade — addressing many of the fundamental questions related to manipulating nanoliter volumes of chemicals and solutions — it still faces some very basic challenges as it moves out of the laboratory and into use. Perhaps most basic is the need for fast, accurate characterization of the size and shape of the microfluidic devices themselves. Conventional imaging and measurement techniques have proven adequate for initial development, but are unable to provide the speed and accuracy needed to support the continued development of microfluidic technologies.

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12

Malecha, Karol, Jan Macioszczyk, Piotr Slobodzian und Jacek Sobkow. „Application of microwave heating in ceramic-based microfluidic module“. Microelectronics International 35, Nr. 3 (02.07.2018): 126–32. http://dx.doi.org/10.1108/mi-11-2017-0062.

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Purpose This paper aims to focus on the application of low temperature co-fired ceramic (LTCC) technology in the fabrication of a microfluidic module with integrated microwave components. The design, technology and performance of such an LTCC-based module is investigated. The rapid heating of liquid samples on a microliter scale is shown to be possible with the use of microwaves. Design/methodology/approach The developed microwave-microfluidic module was fabricated using well-known LTCC technology. The finite element method was used to design the geometry of the microwave circuit. Various numerical simulations for different liquids were performed. Finally, the performance of the real LTCC-based microwave-microfluidic module was examined experimentally. Findings LTCC materials and technology can be used in the fabrication of microfluidic modules which use microwaves in the heating of the liquid sample. LTCC technology permits the fabrication of matching circuits with appropriate geometry, whereas microwave power can be used to heat up the liquid samples on a microliter scale. Research limitations/implications The main limitation of the presented work is found to be in conjunction with LTCC technology. The dimensions and shape of the deposited conductors (e.g. microstrip line, matching circuit) depend on the screen-printing process. A line with resolution lower than 75 µm with well-defined edges is difficult to obtain. This can have an effect on the high-frequency properties of the LTCC modules. Practical implications The presented LTCC-based microfluidic module with integrated microwave circuits provides an opportunity for the further development of various micro-total analysis systems or lab-on-chips in which the rapid heating of liquid samples in low volumes is needed (e.g. miniature real-time polymerase chain reaction thermocycler). Originality/value Examples of the application of LTCC technology in the fabrication of microwave circuits and microfluidic systems can be found in the available literature. However, the LTCC-based module which combines microwave and microfluidic components has yet to have been reported. The preliminary work on the design, fabrication and properties of the LTCC microfluidic module with integrated microwave components is presented in this paper.

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Cartas-Ayala, Marco A., Laura Gilson, Chong Shen und Rohit Karnik. „Oscillations in light-triggered logic microfluidic circuit“. Microsystem Technologies 20, Nr. 3 (24.08.2013): 437–44. http://dx.doi.org/10.1007/s00542-013-1899-4.

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14

Umapathi, Udayan, Samantha Chin, Patrick Shin, Dimitris Koutentakis und Hiroshi Ishii. „Scaling Electrowetting with Printed Circuit Boards for Large Area Droplet Manipulation“. MRS Advances 3, Nr. 26 (2018): 1475–83. http://dx.doi.org/10.1557/adv.2018.331.

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ABSTRACTDroplet based microfluidics (digital microfluidics) with Electrowetting on dielectric (EWOD) has gained popularity with the promise of being technology for a true lab-on-chip device with applications spanning across assays/library prep, next-gen sequencing and point-of-care diagnostics. Most electrowetting device architecture are linear electrode arrays with a shared path for droplets, imposing serious limitations -- cross contamination and limited number of parallel operations. Our work is in addressing these issues through large 2D grid arrays with direct addressability providing flexible programmability.Scaling electrowetting to larger arrays still remains a challenge due to complex and expensive cleanroom fabrication of microfluidic devices. We take the approach of using inexpensive PCB manufacturing, investigate challenges and solutions for scaling electrowetting to large area droplet manipulation. PCB manufactured electrowetting arrays impose many challenges due to the irregularities from process and materials used. These challenges generally relate to preparing the surface that interfaces with droplets -- a dielectric material on the electrodes and the top most hydrophobic coating that interfaces with the droplets. A requirement for robust droplet manipulation with EWOD is thin (<10um) hydrophobic dielectric material which does not break down at droplet actuation voltages (AC/DC, 60V to 200V) and has a no droplet pinning. For this, we engineered materials specifically for large area PCBs.Traditionally, digital microfluidic devices sandwich droplets between two plates and have focussed on sub-microliter droplet volumes. In our approach, droplets are on an open surface with which we are able to manipulate droplets in microliter and milliliter volumes. With milliliter droplet manipulation ability on our electrowetting device, we demonstrate “digital millifluidics”. Finally, we report the performance of our device and to motivate the need for large open arrays we show an example of running multiple parallel biological experiments.

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Lazarus, N., C. D. Meyer und W. J. Turner. „A microfluidic wireless power system“. RSC Advances 5, Nr. 96 (2015): 78695–700. http://dx.doi.org/10.1039/c5ra17479a.

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16

Choi, Sungyoung, Myung Gwon Lee und Je-Kyun Park. „Microfluidic parallel circuit for measurement of hydraulic resistance“. Biomicrofluidics 4, Nr. 3 (September 2010): 034110. http://dx.doi.org/10.1063/1.3486609.

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17

Bang, Seokyoung, Sangcheol Na, Jae Myung Jang, Jinhyun Kim und Noo Li Jeon. „Engineering-Aligned 3D Neural Circuit in Microfluidic Device“. Advanced Healthcare Materials 5, Nr. 1 (02.09.2015): 159–66. http://dx.doi.org/10.1002/adhm.201500397.

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18

Li, Jiang, Yixuan Wang, Enkai Dong und Haosheng Chen. „USB-driven microfluidic chips on printed circuit boards“. Lab on a Chip 14, Nr. 5 (2014): 860. http://dx.doi.org/10.1039/c3lc51155c.

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19

Chen, Xi, Sihui Chen, Yi Zhang und Hui Yang. „Study on Functionality and Surface Modification of a Stair-Step Liquid-Triggered Valve for On-Chip Flow Control“. Micromachines 11, Nr. 7 (16.07.2020): 690. http://dx.doi.org/10.3390/mi11070690.

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Distinctive from other forms of microfluidic system, capillary microfluidics is of great interest in autonomous micro-systems due to its well-engineered fluidic control based on capillary force. As an essential component of fluidic control in capillaric circuits, micro-valves enable sequential fluidic operations by performing actions such as stopping and triggering. In this paper, we present a stair-step liquid-triggered valve; the functionality of the valve and its dependencies on geometry and surface modification are studied. The surface contact angle of the microfabricated valves that are coated by polyethylene glycol (PEG) or (3-Aminopropyl) triethoxysilane (APTES) is evaluated experimentally, and the corresponding reliability of the valve structure is discussed. Moreover, the variation in the surface contact angle over time is investigated, indicating the shelf time of the device. We further discuss the overall fluidic behavior in such capillary valves, which benefits the capillaric circuit designs at the initial stage.

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Issadore, David, Thomas Franke, Keith A. Brown und Robert M. Westervelt. „A microfluidic microprocessor: controlling biomimetic containers and cells using hybrid integrated circuit/microfluidic chips“. Lab on a Chip 10, Nr. 21 (2010): 2937. http://dx.doi.org/10.1039/c0lc00092b.

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21

Sochol, R. D., E. Sweet, C. C. Glick, S. Venkatesh, A. Avetisyan, K. F. Ekman, A. Raulinaitis et al. „3D printed microfluidic circuitry via multijet-based additive manufacturing“. Lab on a Chip 16, Nr. 4 (2016): 668–78. http://dx.doi.org/10.1039/c5lc01389e.

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22

Beißner, Stefan, Jan-Wilhelm Thies, Christopher Bechthold, Philipp Kuhn, Bettina Thürmann, Stefan Dübel und Andreas Dietzel. „Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform“. Journal of Sensors and Sensor Systems 6, Nr. 2 (09.10.2017): 341–50. http://dx.doi.org/10.5194/jsss-6-341-2017.

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Abstract. Quartz-crystal microbalances (QCMs) are commercially available mass sensors which mainly consist of a quartz resonator that oscillates at a characteristic frequency, which shifts when mass changes due to surface binding of molecules. In addition to mass changes, the viscosity of gases or liquids in contact with the sensor also shifts the resonance but also influences the quality factor (Q-factor). Typical biosensor applications demand operation in liquid environments leading to viscous damping strongly lowering Q-factors. For obtaining reliable measurements in liquid environments, excellent resonator control and signal processing are essential but standard resonator circuits like the Pierce and Colpitts oscillator fail to establish stable resonances. Here we present a low-cost, compact and robust oscillator circuit comprising of state-of-the-art commercially available surface-mount technology components which stimulates the QCMs oscillation, while it also establishes a control loop regulating the applied voltage. Thereby an increased energy dissipation by strong viscous damping in liquid solutions can be compensated and oscillations are stabilized. The presented circuit is suitable to be used in compact biosensor systems using custom-made miniaturized QCMs in microfluidic environments. As a proof of concept we used this circuit in combination with a customized microfabricated QCM in a microfluidic environment to measure the concentration of C-reactive protein (CRP) in buffer (PBS) down to concentrations as low as 5 µg mL−1.

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23

Evans, Daniel, Konstantinos Papadimitriou, Nikolaos Vasilakis, Panagiotis Pantelidis, Peter Kelleher, Hywel Morgan und Themistoklis Prodromakis. „A Novel Microfluidic Point-of-Care Biosensor System on Printed Circuit Board for Cytokine Detection“. Sensors 18, Nr. 11 (17.11.2018): 4011. http://dx.doi.org/10.3390/s18114011.

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Point of Care (PoC) diagnostics have been the subject of considerable research over the last few decades driven by the pressure to detect diseases quickly and effectively and reduce healthcare costs. Herein, we demonstrate a novel, fully integrated, microfluidic amperometric enzyme-linked immunosorbent assay (ELISA) prototype using a commercial interferon gamma release assay (IGRA) as a model antibody binding system. Microfluidic assay chemistry was engineered to take place on Au-plated electrodes within an assay cell on a printed circuit board (PCB)-based biosensor system. The assay cell is linked to an electrochemical reporter cell comprising microfluidic architecture, Au working and counter electrodes and a Ag/AgCl reference electrode, all manufactured exclusively via standard commercial PCB fabrication processes. Assay chemistry has been optimised for microfluidic diffusion kinetics to function under continual flow. We characterised the electrode integrity of the developed platforms with reference to biological sampling and buffer composition and subsequently we demonstrated concentration-dependent measurements of H2O2 depletion as resolved by existing FDA-validated ELISA kits. Finally, we validated the assay technology in both buffer and serum and demonstrate limits of detection comparable to high-end commercial systems with the addition of full microfluidic assay architecture capable of returning diagnostic analyses in approximately eight minutes.

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Gray, B. L., S. D. Collins und R. L. Smith. „Interlocking mechanical and fluidic interconnections for microfluidic circuit boards“. Sensors and Actuators A: Physical 112, Nr. 1 (April 2004): 18–24. http://dx.doi.org/10.1016/j.sna.2003.10.073.

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25

Voigt, P., G. Schrag und G. Wachutka. „Microfluidic system modeling using VHDL-AMS and circuit simulation“. Microelectronics Journal 29, Nr. 11 (November 1998): 791–97. http://dx.doi.org/10.1016/s0026-2692(97)00093-1.

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26

Olanrewaju, Ayokunle Oluwafemi, Andy Ng, Philippe DeCorwin-Martin, Alessandra Robillard und David Juncker. „Microfluidic Capillaric Circuit for Rapid and Facile Bacteria Detection“. Analytical Chemistry 89, Nr. 12 (06.06.2017): 6846–53. http://dx.doi.org/10.1021/acs.analchem.7b01315.

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27

Blankenagel, Bryan S., Shiul Khadka, Aaron R. Hawkins, Karl F. Warnick und Brian A. Mazzeo. „Radio-frequency microfluidic interferometer in printed circuit board process“. Microwave and Optical Technology Letters 55, Nr. 7 (26.04.2013): 1616–18. http://dx.doi.org/10.1002/mop.27661.

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28

Zhou, Zhou, Gonghan He, Kunpeng Zhang, Xiaopeng Qi und Daoheng Sun. „A Fluidic Adder Circuit Based on a Microfluidic System“. IEEE Electron Device Letters 40, Nr. 6 (Juni 2019): 977–80. http://dx.doi.org/10.1109/led.2019.2911695.

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Peng, Shu-che, Shailesh P. Nagarkar, Justin L. Lowen und Sachin S. Velankar. „Circuit model for microfluidic bubble generation under controlled pressure“. Microfluidics and Nanofluidics 15, Nr. 6 (21.04.2013): 797–805. http://dx.doi.org/10.1007/s10404-013-1189-6.

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30

Sun, Gongchen, Satyajyoti Senapati und Hsueh-Chia Chang. „High-flux ionic diodes, ionic transistors and ionic amplifiers based on external ion concentration polarization by an ion exchange membrane: a new scalable ionic circuit platform“. Lab on a Chip 16, Nr. 7 (2016): 1171–77. http://dx.doi.org/10.1039/c6lc00026f.

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31

Langer, Krzysztof, und Haakan N. Joensson. „Rapid Production and Recovery of Cell Spheroids by Automated Droplet Microfluidics“. SLAS TECHNOLOGY: Translating Life Sciences Innovation 25, Nr. 2 (27.09.2019): 111–22. http://dx.doi.org/10.1177/2472630319877376.

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The future of the life sciences is linked to automation and microfluidics. As robots start working side by side with scientists, robotic automation of microfluidics in general, and droplet microfluidics in particular, will significantly extend and accelerate the life sciences. Here, we demonstrate the automation of droplet microfluidics using an inexpensive liquid-handling robot to produce human scaffold-free cell spheroids at high throughput. We use pipette actuation and interface the pipetting tip with a droplet-generating microfluidic device. In this device, we produce highly monodisperse droplets with a diameter coefficient of variation (CV) lower than 2%. By encapsulating cells in these droplets, we produce cell spheroids in droplets and recover them to standard labware containers at a throughput of 85,000 spheroids per microfluidic circuit per hour. The viability of the cells in spheroids remains high throughout the process and decreases by >10% (depending on the cell line used) after a 16 h incubation period in nanoliter droplets and automated recovery. Scaffold-free cell spheroids and 3D tissue constructs recapitulate many aspects of functional human tissue more accurately than 2D or single-cell cultures, but assembly methods for spheroids (e.g., hanging drop microplates) have limited throughput. The increased throughput and decreased cost of our method enable spheroid production at the scale needed for lead discovery drug screening, and approach the cost at which these microtissues could be used as building blocks for organ-scale regenerative medicine.

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Peter, Benjamin St, Rainer A. Dressler, Yu-hui Chiu und Timothy Fedkiw. „Electrospray Propulsion Engineering Toolkit (ESPET)“. Aerospace 7, Nr. 7 (04.07.2020): 91. http://dx.doi.org/10.3390/aerospace7070091.

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We report on the development of a software tool, the Electrospray Propulsion Engineering Toolkit (ESPET), that is currently being shared as a web application with the purpose to accelerate the development of electrospray thruster arrays for space propulsion. ESPET can be regarded as a database of microfluidic properties and electrohydrodynamic scaling models that are combined into a performance estimation tool. The multiscale model integrates experimental high-level physics characterization of microfluidic components in a full-scale electrospray propulsion (ESP) microfluidic network performance solution. ESPET takes an engineering model approach that breaks the ESP system down into multiple microfluidic components or domains that can be described by either analytical microfluidic or reduced order numerical solutions. ESPET can be divided into three parts: a central database of critical microfluidic properties, a microfluidic domain modeler, and a microfluidic network solver. Two options exist for the network solution, a detailed multi-domain solver and a QuickSolver designed for rapid design and testing of simple three-domain reservoir-feed-emitter arrays. The multi-domain network solver exploits the Hagen–Poiseuille/Ohm’s law analogy by using the publicly available SPICE (Simulation Program with Integrated Circuit Emphasis) electric circuit simulation software to solve the flow properties of the microfluidic network. Both the multi-domain and QuickSolver solutions offer Monte Carlo analysis of arrays based on user supplied tolerances on design parameters. Benchmarking demonstration examples are provided for experimental work in the literature, as well as recent experimental work conducted at Busek Co. The demonstration examples include ionic liquid propelled systems using active and passive capillary emitters, externally wetted emitter needles, and porous glass emitters, as well as a liquid metal system based on an externally wetted emitter needle.

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Liu, Hai-Tao, Zhi-Yu Wen, Yi Xu, Zheng-Guo Shang, Jin-Lan Peng und Peng Tian. „An integrated microfluidic analysis microsystems with bacterial capture enrichment and in-situ impedance detection“. Modern Physics Letters B 31, Nr. 25 (06.09.2017): 1750233. http://dx.doi.org/10.1142/s0217984917502335.

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In this paper, an integrated microfluidic analysis microsystems with bacterial capture enrichment and in-situ impedance detection was purposed based on microfluidic chips dielectrophoresis technique and electrochemical impedance detection principle. The microsystems include microfluidic chip, main control module, and drive and control module, and signal detection and processing modulet and result display unit. The main control module produce the work sequence of impedance detection system parts and achieve data communication functions, the drive and control circuit generate AC signal which amplitude and frequency adjustable, and it was applied on the foodborne pathogens impedance analysis microsystems to realize the capture enrichment and impedance detection. The signal detection and processing circuit translate the current signal into impendence of bacteria, and transfer to computer, the last detection result is displayed on the computer. The experiment sample was prepared by adding Escherichia coli standard sample into chicken sample solution, and the samples were tested on the dielectrophoresis chip capture enrichment and in-situ impedance detection microsystems with micro-array electrode microfluidic chips. The experiments show that the Escherichia coli detection limit of microsystems is [Formula: see text] CFU/mL and the detection time is within 6 min in the optimization of voltage detection 10 V and detection frequency 500 KHz operating conditions. The integrated microfluidic analysis microsystems laid the solid foundation for rapid real-time in-situ detection of bacteria.

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Biscombe, Christian John Charles, Malcolm Roderick Davidson und Dalton James Eric Harvie. „Comparative evaluation of microfluidic circuit model performance for electroviscous flow“. ANZIAM Journal 52 (26.07.2011): 447. http://dx.doi.org/10.21914/anziamj.v52i0.3945.

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Sudarsan, Arjun P., und Victor M. Ugaz. „Printed Circuit Technology for Fabrication of Plastic-Based Microfluidic Devices“. Analytical Chemistry 76, Nr. 11 (Juni 2004): 3229–35. http://dx.doi.org/10.1021/ac035411n.

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Kawai, Kentaro, Kenta Arima, Mizuho Morita und Shuichi Shoji. „Microfluidic valve array control system integrating a fluid demultiplexer circuit“. Journal of Micromechanics and Microengineering 25, Nr. 6 (19.05.2015): 065016. http://dx.doi.org/10.1088/0960-1317/25/6/065016.

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Oh, Kwang W., Kangsun Lee, Byungwook Ahn und Edward P. Furlani. „Design of pressure-driven microfluidic networks using electric circuit analogy“. Lab Chip 12, Nr. 3 (2012): 515–45. http://dx.doi.org/10.1039/c2lc20799k.

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Chatterjee, A. N., und N. R. Aluru. „Combined circuit/device modeling and simulation of integrated microfluidic systems“. Journal of Microelectromechanical Systems 14, Nr. 1 (Februar 2005): 81–95. http://dx.doi.org/10.1109/jmems.2004.839025.

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Issadore, D., T. Franke, K. A. Brown, T. P. Hunt und R. M. Westervelt. „High-Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit/Microfluidic Chip“. Journal of Microelectromechanical Systems 18, Nr. 6 (Dezember 2009): 1220–25. http://dx.doi.org/10.1109/jmems.2009.2030422.

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Zhang, An-liang, und Yan Zha. „Fabrication of paper-based microfluidic device using printed circuit technology“. AIP Advances 2, Nr. 2 (Juni 2012): 022171. http://dx.doi.org/10.1063/1.4733346.

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Paschew, Georgi, Jörg Schreiter, Andreas Voigt, Cesare Pini, Joseph Páez Chávez, Merle Allerdißen, Uwe Marschner et al. „Autonomous Chemical Oscillator Circuit Based on Bidirectional Chemical-Microfluidic Coupling“. Advanced Materials Technologies 1, Nr. 1 (24.02.2016): 1600005. http://dx.doi.org/10.1002/admt.201600005.

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42

Nguyen, Du T., Timothy D. Yee, Nikola A. Dudukovic, Koroush Sasan, Adam W. Jaycox, Alexandra M. Golobic, Eric B. Duoss und Rebecca Dylla‐Spears. „3D Printing of Compositional Gradients Using the Microfluidic Circuit Analogy“. Advanced Materials Technologies 4, Nr. 12 (06.11.2019): 1900784. http://dx.doi.org/10.1002/admt.201900784.

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Franco, Emilio, Francisco Perdigones, Blas Salvador und José Manuel Quero. „Bonding process using integrated electrothermal actuators for microfluidic circuit fabrication“. Journal of Micromechanics and Microengineering 28, Nr. 7 (17.04.2018): 075006. http://dx.doi.org/10.1088/1361-6439/aababb.

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Shin, Suyeon, Byeongyeon Kim, Yoon-Jin Kim und Sungyoung Choi. „Integrated microfluidic pneumatic circuit for point-of-care molecular diagnostics“. Biosensors and Bioelectronics 133 (Mai 2019): 169–76. http://dx.doi.org/10.1016/j.bios.2019.03.018.

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Nadkarni, Suvid, und Ananth Dodabalapur. „Organic transistor based circuit as drive for planar microfluidic devices“. Journal of Materials Science: Materials in Electronics 18, Nr. 9 (06.02.2007): 931–37. http://dx.doi.org/10.1007/s10854-006-9098-z.

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Zeilmann, Christian, Thomas Haas, Andreas Backes und Ulrich Schmid. „LTCC Based Microfluidic Mass Flow Sensor Concept†“. Journal of Microelectronics and Electronic Packaging 9, Nr. 2 (01.04.2012): 87–96. http://dx.doi.org/10.4071/imaps.331.

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Low temperature cofired ceramics (LTCC) is established as a widespread platform for advanced functional ceramic circuits in many different applications, such as space, aviation, medical, and sensor technology. MLC (multi layer ceramics) based systems allow the integration of passive components, which leads to a high integration level. For microfluidic devices, the integration of 3D structures such as channels and chambers is necessary. Using LTCC will lead to integrating sensor elements due to high reliability, the good ceramic characteristics, and excellent physical properties. To realize 3D micro-channels beyond the laboratory, adequate manufacturing processes are essential. This study proposes the realization of microfluidic channels and shows in which ways these can be realized by a range of newly developed manufacturing methods during the LTCC process. A benchmark of 3D laser structuring and two cold embossing technologies were investigated to show the benefits and also the limits of each technology. The sensor elements, which were directly integrated into the LTCC body, are based on PTC and resistor materials realized in thick film technology. The excellent performance of a microfluidic LTCC system will be shown based on a manufactured demonstrator. The final conclusion is that these established manufacturing and integration methods offer remarkable potential to meet the requirements for future circuit designs, where actual design concepts cannot solve all issues, in particular where harsh environmental conditions occur or a high integration concept is mandatory.

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Xing, Yaru, Yu Liu, Rifei Chen, Yuyan Li, Chengzhi Zhang, Youwei Jiang, Yao Lu et al. „A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology“. Lab on a Chip 21, Nr. 10 (2021): 1886–96. http://dx.doi.org/10.1039/d1lc00101a.

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An active-matrix digital microfluidic platform based on printed-circuit board technology is developed as a robust, highly scalable, low cost, easy to use, and contamination-insensitive device for automatic and parallel droplet handling.

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Ardeleanu, Popescu, Udroiu, Diaconu, Mihai, Lungu, Alhalaili und Vidu. „Novel PDMS-based Sensor System for MPWM Measurements of Picoliter Volumes in Microfluidic Devices“. Sensors 19, Nr. 22 (08.11.2019): 4886. http://dx.doi.org/10.3390/s19224886.

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In order for automatic microinjection to serve biomedical and genetic research, we have designed and manufactured a PDMS-based sensor with a circular section channel using the microwire molding technique. For the very precise control of microfluidic transport, we developed a microfluidic pulse width modulation system (MPWM) for automatic microinjections at a picoliter level. By adding a computer-aided detection and tracking of fluid-specific elements in the microfluidic circuit, the PDMS microchannel sensor became the basic element in the automatic control of the microinjection sensor. With the PDMS microinjection sensor, we precise measured microfluidic volumes under visual detection, assisted by very precise computer equipment (with precision below 1 μm) based on image processing. The calibration of the MPWM system was performed to increase the reproducibility of the results and to detect and measure microfluidic volumes. The novel PDMS-based sensor system for MPWM measurements of microfluidic volumes contributes to the advancement of intelligent control methods and techniques, which could lead to new developments in the design, control, and in applications of real-time intelligent sensor system control.

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Naito, Toyohito, Noritada Kaji, Manabu Tokeshi, Takuya Kubo, Yoshinobu Baba und Koji Otsuka. „Hydrodynamic nonadhesive cell retention in a microfluidic circuit for stressless suspension culture“. Analytical Methods 7, Nr. 17 (2015): 7264–69. http://dx.doi.org/10.1039/c5ay00485c.

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Cell collection based on deterministic lateral displacement (DLD) and cell circulation with a loop channel are two component technologies for stressless cell retention which have been developed with a view to working toward suspension culture in a microfluidic channel.

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Wang, Ke, Peng Zhu, Cong Xu, Qiu Zhang, Zhi Yang und Ruiqi Shen. „Firing Performance of Microchip Exploding Foil Initiator Triggered by Metal-Oxide-Semiconductor Controlled Thyristor“. Micromachines 11, Nr. 6 (29.05.2020): 550. http://dx.doi.org/10.3390/mi11060550.

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In this paper, microchip exploding foil initiators were fabricated by micro-electro-mechanical system scale fabrication methods, such as magnetron sputtering, photolithography, and chemical vapor deposition. A small-scale capacitor discharge unit based on the metal-oxide-semiconductor controlled thyristor was designed and produced to study the performance of the microchip exploding foil initiator. The discharge performance of the capacitor discharge unit without load and the effect of protection devices on the metal-oxide-semiconductor controlled thyristor were studied by the short-circuit discharge test. Then, the electric explosion characteristic of the microchip exploding foil initiator was also conducted to study the circuit current, peak power, deposited energy, and other parameters. Hexanitrostilbene refined by ball-milling and microfluidic technology was adopted to verify the initiation capability of the microchip exploding foil initiator triggered by the metal-oxide-semiconductor controlled thyristor. The results showed that the average inductance and resistance of the capacitor discharge circuit were 22.07 nH and 72.55 mΩ, respectively. The circuit peak current reached 1.96 kA with a rise time of 143.96 ns at 1200 V/0.22 μF. Hexanitrostilbene fabricated by ball-milling and microfluidic technology was successfully initiated at 1200 V/0.22 μF and 1100 V/0.22 μF, respectively.

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