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1
Komínová, Kamila. „Vyhodnocení investice otevření nové prodejny franšízingové maloobchodní sítě“. Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-360152.
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The goal of this diploma thesis is to assess the economic efficiency of the investment consisting in the opening of the new franchise retail network stores, specially Tesco Franchise Stores CR s.r.o. The thesis consists of two main parts - the theoretical part and the analytical part. The theoretical part describes the basic concepts which are related to the investment activities and the methods used to evaluate the investment plans. The ending part of the thesis describes the retail environment and the principles of franchising. The beginning of the analytical parts deals with the strategic analysis and description of the franchise model of the company Tesco Franchise Stores CR s.r.o. In addition, the analytical part focus on a specific investment plan, which is further specified and predicts the expected revenues and costs based and the information obtained from strategic analysis and the financial statements of the company. The end of the analytical part deals with the evaluation of the investment plan using dynamic methods.
2
Ksandr, Václav. „Analýza prodeje dříví v elektronických aukcích a vyhodnocení technologií výroby na LS Kraslice“. Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-258785.
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The thesis analyzes sales of timberusing EADN (Electronicwoodauctions) systemwith a focus on determiningamount of timberavailable on stock in Lesy České republiky, s.p. (theForests of the Czech Republic) and in privatesubject in this market by variousmethods. Themaintaskwas to analyzethesale of timber in electronicauctions and evaluatetechnologiesused in Lesní správa Kraslice (theForest Administration in Kraslice).
The thesis containstheresults of myownmeasurements in harvestedareas in vegetationgroups in theyears 2013, 2014, 2015 in Lesy České republiky, s.p. - Lesní správa Kraslice. The thesis alsofocuses on methods of determiningamount of timberavailable on stock and theexpectedprice (limit) foritssale.Theresults are compared and evaluatedwiththeprivate entity
3
Milka, Jiří. „Statistické vyhodnocení nepřetržitosti dodávky elektrické energie v zadané části distribuční sítě“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220171.
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The thesis is focused on the statistical analysis of the continuity of power distribution in a specified part of the distribution network. Its aim is to explain the basic concepts and calculations in reliability distribution of electrical energy, which is an essential element for improving the quality of electricity supplied to end customers. The work is divided into two parts (theoretical part and a practical part), which are further divided into chapters and subchapters according to individual areas of focus. In the introduction the explains the aim and content of the of chapters work. You are also given a specific issue and its explanation. The conclusion summarizes the results of the practical part. The work is supplemented by annexes a list of images, tables, symbols and abbreviations that are used for better clarity and orientation.
4
Daňhel, Marek. „Hodnocení investičního záměru“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230352.
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The project elaborated within the follow-up master´ s study programme of the M-STM Manufacturing Technology and Management in Industry branch presents an evaluation of a company investment project and recommendations whether to realize the intended investment. The diploma work sets forth an overview of theories in the field of company investment activities, company analysis, details of the investment project and its evaluation. Technical economic analysis of a part fabrication with utilization of new machine equipment, together with conclusions related to the proposed technology, form a part of the project.
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Staňková, Karolína. „Systémy pro určení rytmických struktur v hudebních nahrávkách“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442570.
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This master thesis deals with systems for detecting rhythmic structures of music recordings. The field of Music Information Retrieval (MIR) allows us to examine the harmonic and tonal properties of music, rhythm, tempo, etc., and has uses in academic and commercial sphere. Various algorithms are used in the detection of rhythmic structures. However, today, most new methods use neural networks. This work aims to summarize the current research results of systems for detecting beats and tempo, to describe methods of calculating and evaluating the parameters of music recordings, and to implement a program that allows comparison of available detection systems. The result of the work is a script in the Python language, which uses six different systems to detect the rhythmic structure of test recordings. It then checks the outputs of the algorithms according to the given reference and compares the given systems with each other using several evaluation values. It uses two datasets as a reference—one of them is publicly available and the other was created by the author of this thesis (including annotations, i.e., reference beat times, for the sample recordings). The program allows user to see the results in graphs and play any of the sample recordings with detected beat times.
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Krška, Lukáš. „Experimentální analýza proudu vzduchu z vyústky přístrojové desky osobního vozu s využitím kouřové metody a návrh hodnocení kvality vyústky“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229669.
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The aim of this work was the analysis of air current from the right outlet, using the smoke method and the subsequent determination of a method for application. A further task was to establish a method for determining the upper and lower vertical routing, yaw angle (ß) and angle of inclination (?) of the air current. The experiment aims to approximate conditions as close to those experienced in the actual vehicle. After assembling a track with a soot blower (outlet) in the laboratory and defining the coordinates of the vehicle, the air current was subjected to visualization within the range of five positions of the vanes. Visualization was achieved by the use of technology for the smoke method. We used a light plane with a customized system of coordinates, a smoke generator for visualizing the air current being emitted and a camera for recording images. During our research we established the upper and lower cut off at the specific closures of the horizontal vanes of the soot blower. We determined a common analogy between the experimental track used in the experiment and the circumstances in the actual vehicle. We acquired the yaw angles (ß) and the angles of inclination (?) in the light plane and, after conversion, in the system of coordinates of the vehicle for all five settings of the vanes. The assessment of the given soot blower was undertaken according to the values achieved.
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Jurán, Antonín. „Efektivní obrábění nových konstrukčních keramických materiálů“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2009. http://www.nusl.cz/ntk/nusl-228424.
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The objective of this diploma thesis are new design materials in a view of their structure, properties, manufacture,partitions, applications and possibili-ties of effective machining them Ceramics are used in the field of design applications more often than before. They are in form of compact parts and in form of thin coatings on the surface of metal parts. Fast development of constructive applications requires the same progress rate of machining ma-chines innovations and development of new methods of effective machining these materials, too. The aim is to produce parts of demanded shapes, dimensions and surface quality at affordable costs. Ceramics guarantee long terming durability and reliability. The evaluation of ceramics grinding tests from the point of view of cutting forces and surface quality of the machined faces are presented in the last part of the diploma thesis.
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Čechová, Simona. „Vyhodnocení zatěžovacích zkoušek pilot z tryskové injektáže“. Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2021. http://www.nusl.cz/ntk/nusl-433418.
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The master thesis consists of a theoretical part and a practical part. In the theoretical part jet-grouting technology is described briefly. Mechanical properties of jet-grouted piles were characterized. Various estimation methods of ultimate pile bearing capacity are described in this thesis – analytical calculation of ultimate bearing capacity for bored piles and estimation of ultimate pile bearing capacity by analysis of load-displacement curve defined by CHIN (1970; 1972). Load transfer method for piles and hyperbolic load-transfer curve are introduced. As a part of the load-trasfer method analysis, a method of estimating ultimate pile shaft friction called beta method is defined. In the practical part were evaluated several static load tests of jet-grouted piles and were constructed their load-displacemnt curves. Then reverse analysis of the results from static load tests was performed using load-transfer method. Then ultimate pile bearing capacity was estimated using analytical calculation of pile bearing capacity for bored piles and using analysis of load-displacement curve with method by CHIN (1970; 1972). By evaluation of load transfer method and beta method ultimate shaft resistence for each pile was estimated. Results and load-displacement curves were compared.
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Boháčková, Klára. „Vyhodnocení změny projektové metodiky v obchodní organizaci“. Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-76077.
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The thesis is focused on analysis and comparison of the company's internal project methodology and official project methodology PRINCE2. This thesis aims to evaluate which of the methodologies is more suitable for management of projects in Ahold. A comparative qualitative analysis is used for the comparison of the project methodologies. The analysis is mainly focused on comparison of project phases, processes and documents. Furthermore concrete project is used to substantiate how each of these project methodologies would influence its realization. Comparing internal methodology and PRINCE2 methodology it was found that the internal project methodology that respects the specifics of Ahold is better for project management than official methodology PRINCE2.
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Tichý, Štěpán. „Technologie drátové elektroeroze“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-231987.
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This master’s thesis deals with technology of wire electrical discharge machining in theoretical and practical level. Theoretical part of the thesis explains in detail the principle of electrical discharge machining, describes functional parts and settings of a current wire EDM machines and also the possibility of using method for production of specific parts. Practical part of the thesis solves manufacturing of gearing on pinion manufactured by wire cutter EXCETEK V650 and statistically evaluates precision parameters on surfaces of the carriers taken by specific technological conditions with the same machine.
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Soukup, Ladislav. „Vyhodnocení srdečního výdeje bioimpedanční metodou u pacientů se stimulátorem“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219749.
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This thesis deals with the possibility of using impedance cardiography for calculating cardiac output. Kubicek’s, Sramek‘s and Sramek-Bernstein‘s methods are discussed here. These methods were applied to a data set, obtained by measuring on subjects with implanted cardiostimulators. The subjects’ heart rate was being changed by the programing of cardiostimulators. Thanks to this procedure the measured data were not affected by artifacts, connected with the heart rate change caused by a body stress, or other influences. An influence of heart rate on a cardiac output value based on the statistical processing of the data set was studied.
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Mošna, Martin. „Vyhodnocení dopadů zavedení metodiky PRINCE2 ve vybrané konzultační společnosti“. Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198474.
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This thesis describes project management methodology implementation in a consulting company and examines the impact of this methodology on key success factors of the company. The theoretical part deals with issues related to project management implementation in a company and describes well-known methods and standards in this area while focusing on PRINCE2 methodology, which has been chosen for the implementation. The theoretical part continues by describing the process of creating system dynamics models, which allowed the key success factor models to be created as tools for evaluation of the methodology implementation impacts. The practical part of this thesis describes the background for the methodology implementation project and then the implementation itself in detail. The practical part continues by showing and describing the created key success factor models. In the end, the methodology impacts evaluation is carried out, analyzing changes in separate elements of the model breakdown.
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Stehnová, Miroslava. „Vyhodnocení efektivity zateplení bytového domu“. Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2012. http://www.nusl.cz/ntk/nusl-225661.
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The thesis is focused on the evaluation of the effectiveness of a residential building. For processing was used itemized budget insulated apartment building created in the program Kros and critique energy performance of buildings. The work evaluates the effectiveness of insulation and return on investment costs.
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Janáček, Martin. „Parazitární onemocnění trichinelóza – charakteristika a vyhodnocení známých dostupných detekčních metod“. Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-256943.
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Trichinellosis is a worldwide serious disease transmittable from animals to humans. The disease agent is Trichinella spp., which belongs to the phylum of parasitic nematoda called Nematodes. There are 12 genotypes of Trichinella currently known but the most important for the Czech Republic and neighboring countries are T. spiralis, T. britovi and T. pseudospiralis.
Man can be infected by ingestion of raw or undercooked meat of infected animals. Treatment is very expensive and can be fatal, therefore a great emphasis is placed on prevention, especially control of animal carcasses which are intended for human consumption. The most famous method, also approved by law, is the digestive method, however there are many other methods for testing the presence of a parasite or for specification of genotype.
This paper mainly deals with comparison of known and available methods of detection of trichinosis originators. Furthermore this paper gives character description of majorgenotypes of Trichinella.
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Kršík, Jakub. „Numerické modelování předpjatých dutinových panelů typu Spiroll na pružném podepření a vyhodnocení průběhu napětí“. Doctoral thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-392319.
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The doctoral thesis describes the possibilities of numerical modelling of hollow core concrete panels, SPIROLL type. The commercial finite element program ANSYS 13.0 is used for the modelling. The focus is on the specific flexural support of the panel and on the distribution of the shear stresses in the panel ribs near the support. The goal is to valid actually used method for homogenization of the panel’s foreheads and its influence on the shear resistance by using four numerical models. The numerical models are compared and verified with two experiments. The first experiment is vacuum loading on the hollow core slab. Second experiment is about shear loading by applying the loading blocks. Four methods for design of hollow core panels are evaluated. It is the method based on main stresses, design according EN 1992 and EN 1168 and Yang’s method of prestress effects transfer. Based on the results, a method of considering flexural support for the evaluation of hollow core panels is proposed.
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Krejsová, Věra. „Vyhodnocení vývoje cen stavebních pozemků dle cenových předpisů“. Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-232885.
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The aim of this work is to identify trends in prices building plots over the years, the price set by the price regulations is determined according to the legislation in force for the years, this legislation is detailed and chronologically sorted in the theoretical part of this thesis. The actual valuation of building plots is carried out since 1939 to the present in the practical part of this work. The award is made over the years to the identical construction site located in the town of Olomouc.
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Štěpanovský, Libor. „Vyhodnocení provozního stavu asynchronních motorů jaderné elektrárny Dukovany metodou frekvenční analýzy statorového proudu“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442548.
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The masters thesis is concerned with the setting of limits and criteria, the design of database environment and the evaluation of the current state of motors of the important machines related to own consumption of the Nuclear power plant Dukovany. The first part of the thesis is a short description of induction motors, the evaluation method and the inventory of the observed motors related to own consumption of Nuclear power plant Dukovany. The second part of the thesis concerns the design of limits and criteria for evaluating the current state of these important motors. Finally, the thesis shows a short description of the electro monitoring system together with the description of the database environment created. In the supplementary materials of the thesis, there is a design of a protocol template for evaluation of the current state of the motor and a technical report template for regular evaluation in monitored areas MCSA (Motor Current Signature Analysis) of the state of the induction motors.
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Mrhálková, Hana. „Analýza efektivity vzdělávacího programu realizovaného v nadnárodní společnosti“. Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198230.
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This master thesis deals with the analysis of the training program, which is implemented in a multinational outsourcing company. During the analysis of training program I am using knowledge of Kirkpatrick model and Success Case Method study, which are described in theoretical part. The aim of this thesis is to describe the processs of the training program (focusing on the description of leadership techniques) and evaluate this course. The basic premise of the thesis is that the training program has positive feedback in the company and it has also good reputation. I'm trying to confirm those claims through an evaluation of questionnaire survey and interviews with graduates of the training program. Evaluation will give me information about employee satisfaction with the organization and content of the course, with the knowledge and skills of the teacher, etc. The questionnaires are focused on identifying what the graduates have learned, how much of it they have used in practice and what they have accomplished thanks to those knowledge. To extend this information I used personal interviews, which provide me with specific examples of the use of leadership techniques in various situations in workplace. Finally, I summarize all the results and make recommendations that would increase the effectiveness of the course.
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Kováč, Frederik. „Zpracování metodiky a podpory pro vyhodnocení naměřených hodnot uzemnění stožárů VVN v souvislosti s PNE 33 3300-1“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413210.
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Diploma thesis is oriented on measuring and evaluation of grounding conditions of HV pylons. In theoretical part is described theory of grounding including related legislation, impact of electric current on human body, methods of measuring earth resistance, soil resitivity and description of available measurers. Practical part is focused on measuring earth resistance of selected pylons and measuring procedures followed by evaluation of measurements according to person's safety from dangerous touch voltage and impact of lightings. For evauluation of measured data is created supporting tool in MS Excel. In the last part of thesis are described recommendations for cutting-down touch voltages.
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Kosařová, Zuzana. „Využití metod štíhlé výroby na vybraném pracovišti“. Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-377624.
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The diploma thesis is focused on proposal of workplace modification according to the lean manufacturing methodology (DMAIC). The target is to minimize the wasting and to increase the production efficiency based on LEAN tools implementation. The theoretical part of the thesis defines the basic terms, such as primarily lean production, DMAIC, wasting. In the practical part there is at problem analysis using the DMAIC method, then the proposal for improvement is solved, that contains reduction of wasting, process of the project, timetable, costs and implantation of the solution, finally there is evaluated the benefit.
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Červinková, Kateřina. „Citlivostní analýza metody tlak-čas na nepřesnosti měření“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400848.
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The pressure-time method is one of two methods of measuring the flow rate on large hydraulic structures applicable to IEC 60041, which is based on the temporal integration of the measured pressure difference and the formation of a water hammer in a closed pipe. The aim of this master thesis is to perform a literature review of this method and to evaluate the flow rate of the measured data. Furthermore, the thesis deals with determination of the sensitivity of the evaluated flow rate to the weights of individual pressure sensors and to numerical modifying of the measured pressures. The first part is made using MS Excel. The flow rate is always evaluates with only one pressure sensor and it is compared with the original flow rate. There is research, how absence of the sensor has an impact on the evaluated flow rate. In the second part of the determination of the sensitivity of the evaluated flow rate, various encroachment (signal smoothing, noise, time delay, frequency band removal) are performed of measured pressure signal in Matlab. Various surrounding influences or sensors failures are simulated.
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Černoch, Adam. „Vyhodnocování dopravního hluku a jeho modelování“. Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2014. http://www.nusl.cz/ntk/nusl-226952.
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The task of the master's thesis is introduction with the problems of traffic noise, focusing on noise from road traffic. There is a description what is the noise, how it is formed, its resources and what are the methods of measuring. The following are the various noise reduction measures such as noise barriers and low noise pavements. The main attention is devoted to the noise generated at the tire / road that is reduced by these pavements. The practical part describes the implemented measurements on individual sections at various locations in our country. The measurement was carried by slightly modified method CPX with reference tire directly at the vehicle. The main aim was to evaluate the measurement data, make comparison of different low-noise surfaces with each other and with the commonly used surfaces. Then quantification of the rate reduction of the noise emission for a given section and verification of input data for noise modeling. In conclusion, the obtained results are summarized and based on them were confirmed very good acoustic properties with the recommendation to continue with measurements in the future.
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Šeda, Libor. „Analýza proudění z vyústky osobního vozu s využitím termoanemometrické sondy“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-231972.
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In this master’s thesis there are summarized fundamental findings about air flow velocity measurements and afterwards introduced the measuring track for automobile car vents, measured object and track arrangement and all used components. Velocity field measurement method is how wire anemometry, and apart from 4 main cases measurements of free air jet, there are velocity profiles in piping measured as an input for CFD simulation. Air vent evaluation criteria are described and their assessment is done for specified cases. Further, there is a CFD simulation presented with comparison to experimental data. Uncertainty of flow rate measured and flow rate setting is determined. Improvement points and encountered issues are presented. Visualization and evaluation program coded in MATLAB environment enables easy data display of CTA results and will serve further vent quality assessment.
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Novotný, Roman. „Návrh metod hodnocení ukazatelů efektivity civilních letišť“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229907.
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Introductory part of this thesis concludes the development of air traffic, division of airports in the Czech Republic according to the Ministry of Transport, according to the Law on Civil Aviation and according to the Coding of the airports (Requirement L 14). The aim was to realize theoretical definition and division of output and economic indicators. After that comes choice of appropriate airports from the European Union. The choice has been made on the basis of the number of check-in passengers at the airport in Prague-Ruzyně. Eight most suitable airports have been chosen from all twenty-seven member countries of the EU. The following step is comparative analysis of these chosen airports on the basis of specified output and economic indicators for the years 2005-2009. The year 2010 has not been included, because the chosen airports did not complete their annual reports, balances and statements of profit and loss. From these sources the values for calculation of individual indicators have been chosen. These indicators have been shown in charts, evaluated by means of graphs in Excel Programme and further they have been characterized in words. The aim of the thesis was also the evaluation and comparison of output and economic indicators of effectiveness and after evaluation, proposal of methods of evaluations has followed.
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Janoušková, Dominika. „Srovnání vybraných způsobů ocenění pro nemovitost typu byt v lokalitě Pardubice a Prosetín“. Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-233148.
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Výpustek, Libor. „Průzkum a hodnocení mostu na dálnici D2“. Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2013. http://www.nusl.cz/ntk/nusl-225738.
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This thesis deals with the exploration and evaluation of the existing bridge carried him on the highway D2. The work is divided into theoretical and practical parts. The theoretical part focuses on the technical surveys, diagnosis of building structures and some methods of investigation and testing of building structures. In the practical part the visual inspection and diagnosis of disorders of the highway bridge substructures ev. No. D2-058, to determine material characteristics substructure and evaluate the state of the bridge. In conclusion, the practical part of the recommendations for the design and method of repairing the bridge.
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Gabriš, Ondrej. „Software Projects Risk Management Support Tool“. Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2011. http://www.nusl.cz/ntk/nusl-412827.
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Management projektů a jejich rizik je v současnosti rozvíjející se disciplína, která si získává stále větší pozornost a uplatnění v praxi. Tato práce popisuje úvod do problematiky řízení rizik, zkoumání metod jejich identifikace, vyhodnocení a managementu, předcházení jejich následkům a jejich zvládání. V další části práce byla provedena analýza vzorků rizik z reálných projektů, byly popsány metody pro identifikaci a vyhodnocení následků rizik v úvodních fázích softwarového projektu, taktéž byly popsány atributy rizik a navržen způsob jejich dokumentace. V závěrečné části zadání byl navržen a implementován prototyp modelové aplikace pro podporu managementu rizik softwarových projektů.
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Kvítková, Lenka. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční metody“. Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-281169.
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Kvítková L.: Evaluation of in vitro activity of potentially antifungal compounds by microdilution broth method - VIII. Over 250 new synthetized compounds divided into 16 chemical groups were tested by microdilution broth method for the establisment of in vitro antifungal activity. This method is based on the standard M27-A (Clinical Laboratory Standard Institute). RPMI 1640 medium buffered to pH 7.0 with MOPS was used and standardized inoculum was prepared from fresh fungal isolates grown on Sabouraud agar. All compounds tested were dissolved and diluted in DMSO. The MICs were determinated visually after 24 or 48 hours of incubation at 35C. The compounds were tested against eight fungal strains. The structure-activity relationships were studied and compared with the calculated log P values. Hydrophobicity of compounds (log P) was computed using the program ACD/LogP (Advanced Chemistry Development Inc., Ontario, Canada). The most active compounds were the derivatives of (E)-1-pyrazine-2- ylethane-1-one-thiosemicarbazone; the majority of the compounds showed moderate or high efficacy against all fungal strains tested. There were several compounds of the groups tested with a considerable antifungal effect, as well. The most susceptible fungal strain was Trichophyton mentagrophytes, on the contrary,...
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Andělová, Magdaléna. „Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-350774.
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Charles University in Prague Faculty of pharmacy in Hradec Králové Department of Biological and Medical science Candidate: Magdaléna And lová Supervisor: Mgr. Marcela Vejsová, Ph.D. Name of diploma thesis: Evaluation of activity of potentional antibacterial substances throught of the use microdilution broth metod Background Aim of this diploma work was research of activity of potentional antimicrobiotic substances. Research of antibacterial substances is one of the most important factor in pharmaceutic industry. The main reason is being the never stopping growth of bacterial resistence. Methods The microdilution broth metod was used to test the substances. This metod was used because of low difficulty and low cost. All the steps including the final analising was done by hand. Results The substances were divided in groups depending their chemical struction. The most effective was the salicylanilide derivates group. The other groups inhibitated growth of bacteria very little or were non-functional. In case of every bacterial stems were analised all substances which were effective. Conclusion Depending on the results the most sensitive and the most resistant bacterial stem were choosen. The most sensitive reaction on tested substances had bacterial stem Staphylococcus aureus. The Klebsiella pneumoniae...
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Navrátil, Radek. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-303930.
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Radek Navrátil Evaluation of activity of potentional antifungal substances through the use of microdilution broth method. Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy The aim of this thesis was to assess the antifungal activity of substances prepared at the Department of pharmaceutical chemistry and drug control, Faculty of Pharmacy of Charles University in Hradec Králové. Substances were tested through use of microdilution broth method at eight strains of pathogenic fungi: Candida albicans, C. tropicalis, C. krusei, C. glabrata, Trichosporon beigelii, Aspergillus fumigatus and Trichophyton mentagrophytes. Substances were divided into nine groups according to their common structural characteristics. The most effective were the derivates of 2-[(1-heteroarylethyliden) hydrazon]-1,3-thiazolidin-4-one with the lowest values of MIC. Derivates of 5,6- diazine-2,3-dicarbonitrile presented no activity. The rate of susceptibility for each tested strain was evaluated. The most susceptible were the Candida albicans and Trichophyton mentagrophytes strains. On the contrary, Aspergillus fumigatus and Candida tropicalis were presented as the most resistant. Chlorine substitution of pyrazine presented a slight increase of antifungal activity. It is necessary to carry...
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Drbohlavová, Anna. „Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-325083.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Anna Drbohlavová Supervisor: Mgr. Marcela Vejsová, Ph.D. Diploma thesis title: Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method Objective The occurrence of resistant bacteria strains is the global problem today, which influences everyone's life. One of the way, how to solve this problem, is to develop new effective antibacterial substances. The goal of the diploma thesis was to test 70 potencial medical drugs and find out their antibacterial activity against selected bacteria strains. Methods The minimal inhibitory concentrations of tested substances, affecting the growth of the most common 8 conditionally pathogenic bacteria, including significant resistant strains such as MRSA and Klebsiella pneumoniae producing extended specter beta lactamase, were monitored by microdilution broth method. Results Tested substances were divided into eight groups according to their chemical structure and then their antibacterial effect was compared. The most effective group was presented by salicylanilide and its derivates. The influence of the chemical structure and production of clot in growth medium of these substances on...
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Žmolová, Markéta. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-330061.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Markéta Žmolová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antifungal substances through the use of microdilution broth method. Objective: With the growing number of systemic fungal diseases and occurrence of resistant strains of fungi it is still necessary to conduct research of new potential drugs. The aim of the thesis was to determine antifungal activity in vitro with 70 substances, which were divided into six groups according to chemical structure. Methods: Antifungal effect was tested on 8 strains of pathogenic fungi, including 5 strains of yeasts and 3 strains of moulds. The microdilution broth method was used for testing. Results: The most expressive antifungal activity showed by a group of substances derived from salicylanilide. SAL-5-Cl-4-Br was the most effective substance, which had a good effect on Trichosporon asahii strain and it reached the lowest value MIC (0,98 µmol/l) at Trichophyton mentagrophytes from all tested substances. The substances derived from sulfonamides showed a good effect too, particularly on strain Trichophyton mentagrophytes. Derivatives of itaconeamide were ineffective and even...
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Tichá, Monika. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-335135.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Monika Tichá Supervisor: Mgr. Marcela Vejsová, PhD. Title of diploma thesis: Evaluation of activity of potentional antifungal substances through the use of microdilution broth method Background: The aim of this thesis was evaluation of activity of potentional antifungal substances through the use of microdilution broth method. Total of 52 substances were tested. Substances were synthetisized at Department of Pharmaceutical Chemistry and Drug Control (Mgr. Jandourek, Mgr. Semelkova). All substances were pyrazine derivates, the substances were divided into six group. Sensitivity of the 8 strains was tested - Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon asahii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes. Methods: Microdilution broth method was used. Results: Total of 24 substances displayed antifungal effect, the lowest MIC was 62,5 µmol.l-1 . The most sensitive strain was Trichophyton mentagrophytes, the least sensitive was Candida albicans. Derivates of N-benzylpyrazine-2-amine were the most active group of the substances. Conclusion: Alkyls with long hydrocarbon chain appeared to be profitable substituents...
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Pospíchalová, Jana. „Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-335918.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Jana Pospíchalová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method The aim of this thesis is to evaluate activity of potentional antibacterial substances synthesized at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové. For testing of the antimicrobial activity was used microdilution broth method. This method is suitable for the quantitative determination of antimicrobial susceptibility. The substances were tested at eight bacterial strains, which consisted of Gram pozitive and Gram negative bacteria including resistant agents of serious nosocomial infections. 52 tested substances were dividend into 6 groups based on a common structure. The most effective group was evaluated by a group of N-benzyl-3-chloro-pyrazin-2-carboxamide and the most effective substance of all tested was 3-chloro-N- (3,4-dichlorobenzyl) pyrazine-2- carboxamide belonging to this group. Most sensitive to the tested substances showed Staphylococcus aureus and Staphylococcus epidermidis.
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Drnková, Nela. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-342030.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Nela Drnková Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potencial antifungal substances trought the use of microdilution broth method Background: The aim of this thesis was evaluation of antifungal activity of 70 substances trought the use of microdilution broth method. Substances for testing were synthesized at the Faculty of Pharmacy and they were divided into 5 groups based on chemical structure. Methods: The microdilution broth method was used for testing. The antifungal activity of substances was tested on 8 strains of yeasts and filamentous fungi: Candida albicans, C. tropicalis, C. glabrata, C. krusei, Trichosporon asahii, Aspergillus fumigatus, Absidia corymbifera a Trichophyton mentagrophytes. Results: The most active substances were in group of salicylanilide N- monosubstituted and N,N-disubstituted carbamates and thiocarbamates. The most effective substances were SAL-1L, SAL-1M, SAL-1N. They were effective on Trichophyton mentagrophytes already at concentration of 1,95 µmol.l-1 . The widest spectrum had substance GP-137, it inhibited the growth of all tested strains, but only at high concentrations. Rhodamine...
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Ťapuchová, Ivana. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody“. Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355810.
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Department of Biological and Medical Sciences Faculty of Pharmacy in Hradec Králové Charles University in Prague Author: Ivana Ťapuchová Title of diploma thesis: Evaluation of activity of potentional antifungal substances through the use of microdilution broth method Supervisor: Mgr. Marcela Vejsová, Ph.D. Background: The aim of this diploma thesis was to evaluate potential antifungal activity of 52 test substances which were develope at the Department of anorganic and organic chemistry Faculty of Pharmacy in Hradec Králové Charles University in Prague. Methods: For testing we used microdilution broth method on eight strains of yeasts and filamentous fungi in the laboratory of Department of Biological and Medical Sciences. Results: Overall 26 test substances with various substituents had antifungal activity. These substances was derivates of 4-aminobenzoic acid, 4-aminosalicylic acid, 5-aminosalicylic acid and large group derivates of sulfonamids. The most sensitive strain was dermatophyt Trichophyton mentagrophytes, the least sensitive strain was filamentous fungi Absidia corymbifera. Conclusions: Despite there was observed antifungal activity in low concentrations of derivates, it is necessary to perform next tests and clinical studies to prove efficiency and safety for use. Key words: yeasts,...
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Matoušková, Jarmila. „Vyhodnocení genetické variability bobra evropského v ČR“. Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-95596.
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Zavřelová, Alena. „Vyhodnocení aktivity potenciálně antimykotických látek pomocí mikrodiluční bujónové metody III“. Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-334695.
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Title of thesis: Evalution of activity of potentional antimycotic substances through the use of microdilution broth method III Autor of thesis: Alena Zavřelová Supervisor: Mgr. Klára Konečná, Ph.D. Background: The aim of this thesis, due to the growing incidence of fungal diseases and the growing incidence of resistance, was to determine the activity of potentially antimycotic active substances. We tested newly synthesized compoused, structurally based on the substance of pyrazinamide which is significant antituberculotic. Methods: Testing of substances was carried out using a broth microdilution method on eight strains of pathogenic fungi consisting of five yeast strains: Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon asahii and three strains of filamentous fungi: Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes. Results: From the range of tested concentrations and from the total number of the thirty tested substances, the most noticeable antifungal aktivity was revealed in the substance of 5-methyl-6-(2-phenylhydrazinyl)pyrazine-2,3- dicarbonitrile. All strains, except Trichophyton mentagrophytes strain, showed a relatively...
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Kopečná, Klára. „Vyhodnocení aktivity potenciálně antibiotických látek pomocí mikrodiluční bujónové metody II“. Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-343393.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of biological and medical sciences Study program: Pharmacy Autor: Klára Kopečná Supervisor: Mgr. Klára Konečná, Ph.D. Title of diploma thesis: Evaluation of activity of potencional antibiotic substances through the use of microdilution broth method II Background: To evaluate the antibacterial activity of the compounds synthesized by the Department of Pharmaceutical Chemistry and Drug control, Faculty of Pharmacy in Hradec Králové, Charles University in Prague under the leadership of prof. PharmDr. Martin Doležal, Ph.D. Methods: Using broth microdilution method was tested antibacterial activity at eight bacterial strains, namely Staphylococcus aureus, Staphylococcus aureus methicilin resistant, Staphylococcus epidermidis, Enterococcus sp., Escherichia coli, Klebsiella pneumoniae, Klebsiella pneumoniae ESBL positive and Pseudomonas aeruginosa. Results: Test substances were divided into 5 groups according to similarities in the chemical structure. The best antibacterial activity was observed in the group of derivatives of N-benzyl- 6-(alkylamino)pyrazine-2-carboxamide. Conclusion: Antibacterial activity was detected in 10 of 24 tested compounds. From active substances, all but one danced only Gram-positive bacteria. Among...
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Štvrtecká, Jana. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody I“. Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279156.
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Jana Štvrtecká Evaluation of activity of potentional antifungal substances through the use of microdilution broth method I Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralové Medical bioanalytic_____________________________________________________ The aim of this thesis is to evaluate the potencial in vitro antifungal activity of selected drugs synthetised on the Department of Pharmaceutical Chemistry and Drug Control and on the Department of Anorganic and Organic Chemismy on the Faculty of Pharmacy in Hradec králové. For drug testing was used the microdilution broth method. The tested compounds were tested on followed five yeast strains and three filamentous fungi models which are pathogenic for humans: Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E28, Candida glabrata 20/I, Trichosporon beigelii 1188, Aspergillus fumigatus 231, Absidia corymbifera 272, Trichophyton mentagrophytes 445. 80 compounds were divided into 10 groups accorging to their chemical structures: anilides of pyrazin carboxyl acids, arylamin pyrazines, pyrazin carboxyl acid esters, pyrazine-2,3-dinitriles, benzoxazepin-diones, diamides, styryl benzoxazoles, derivatives of (Z)-5-arylmethyliden-2-thioxothiazolidin-4-on, ester derivatives of cholesterol and alcan acids and...
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Navrátilová, Kristýna. „Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody I“. Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279457.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Pharmacy Candidate: Kristýna Navrátilová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antibacterial substan- ces through the use of microdilution broth method I Background Development of new antibacterial agents is still and will be always an impor- tant area of pharmaceutical industry. The need to discover new drugs is growing resistance of pathogenic bacterial strains. Aim of the work was to test new potencial antibacterial active substances on antimicrobial activity. Methods As part of this thesis was by using microdilution broth method tested for antibac- terial activity against eight chosen bacterial strains 106 chemicals newly synthesized by the Departments of the Faculty of Pharmacy in Hradec Králové. The described method is used as a screening for pre-determining of the effectiveness of antimicro- bial agents. Results Substances were divided into ten groups according to chemical structure. The most effective was reflected group of salicylthioamid derivates. These substances belong to this group inhibited bacterial growth of all tested strains by very low concentrations already. For each tested bacterial strain...
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Fučíková, Eliška. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody II“. Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279463.
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Eliška Fučíková Evaluation of activity of potentional antifungal substances through the use of microdilution broth method II Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Specialist in laboratory methods Background: The aim of this thesis was to test substances with potential antifungal effect. We tested a totally 10 cathegories of substances: anilides of pyrazincarboxyl acid, arylaminopyrazines, pyrazin-2.3-dinitriles, pyrazincarboxyl acid esters, derivatives of (Z)-5-arylmethyliden-2-thioxothiazolidin-4-on, cholesterol and alkane acids esters, derivatives of thiosalicylamid , diamides, styrylbenzoxazoles, benzoxazepin-diones. Methods: The assesment was carried out using the microdilution broth method. Results: The most striking antifungal activity exhibit derivatives of thiosalicylamid for which MIC values were very low in almost all scale of concentration for all tested fungi. Conclusions: We found that the greatest antimycotic activity is manifested with the substitution of a halogen, mostly by chlorine.
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Rosíková, Pavla. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody II“. Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-279501.
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Rosíková Pavla Evaluation of activity of potentional antifungal substances through the use of microdilution broth method II Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Pharmacy The aim of this diploma thesis was testing of samples of substances produced at the Department of Pharmaceutical Chemistry and Drug Control and the Department of Inorganic and Organic Chemistry Faculty of Pharmacy of Charles University in Hradec Kralove. Substances were tested by using microdilution broth method. Testing was carried out on eight strains of yeasts and filamentous fungi: Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes. Total were tested 49 substances, which are divided into four groups according to their chemical structure. Derivatives pyrazin-2-carboxamide, 3-derivatives hydrazinopyrazin-2- carboxamide, 2-derivatives isonikotinoylhydrazinkarboxylate, benzoxazin derivatives. Group of derivatives pyrazin-2-carboxamide, which is substituted by low alkyl (-CH3) in the position 5 of pyrazin, and in which is nitrogen of amid group subtituted by the phenyl with electronegative group (-CF3,-F,-Cl,-OH) or with hydroxy group in position m, showed higher...
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Nitraiová, Jindřiška. „Vyhodnocení aktivity potenciálně antifungálních látek pomocí mikrodiluční bujónové metody I“. Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-279511.
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1. Abstract Jindřiška Nitraiová Evaluation of activity of potentional antifungal substances through the use of microdilution broth method I Diplomová práce Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Farmacie The aim of the thesis was a screening of activity of new potentional antifungal substances. For testing of substances was used the microdilution broth method. This method allows a routine assesment of MIC of a larger amount of antimycotics and also complete strains. The compounds for the strains Candida albicans, C. tropicalis, C. glabrata, C. krusei, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera a Trichophyton mentagrophytes were tested. The derivates of pyrazinedicarbamide, pyrazinedicarbothioamide, pyrazole-1- carboxylate, hydrazinecarboxylate, diazene-1,2-dicarboxamide and cyclohexanone did not show any antimycotic effectiveness. On the contrary the derivates of benzamide and benzenecarbothioamide showed a good antimycotic activity against all the testing strains. In the group of other substances, it means the derivates of pyrazinecarboxamide, pyrazinecarbothioamide, pyrazine-anilides, pyrazine-2-amine, pyrazine-2-carbohydrazide and pyrazine-2,5-dicarbonitrile and thiazolidine-4-one, some substances were effective but some had no effect. The derivates of...
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Stanciová, Cristina. „Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody II“. Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-299248.
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5 Abstract Cristina Stanciová Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method II Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Specialist in laboratory methods The aim of this thesis was to test substances produced by the Department of Pharmaceutical Chemistry and Drug Control and the Department of Inorganic and Organic Chemistry Faculty of Pharmacy of Charles University in Hradec Králové. Substances were tested by using microdilution broth method. Testing was carried out on eight strains of the bacteria: Staphylococcus aureus, Staphylococcus aureus methicilin resistant, Staphylococcus epidermidis, Enterococcus sp., Escherichia coli, Klebsiella pneumoniae and Pseudoonas aeruginosa. Overall were tested 97 substances, which were divided into ten groups according to their chemical structure to: derivatives of (Z)-5- arylmethyliden-2-thioxothiazolidin- 4-on, anilids of pyrazinocarboxyl acid, arylaminopyrazins, pyrazin-2,3-dikarbonitrils, esters of pyrazincarboxyl acid, N- (2-anilino-1-alkyl-2-oxo-ethyl)-2-hydroxy-benzamides, esters of cholesterol and alkan΄s acids, salicylthioamids, styryl benzoxazols and benzoxazepin-dions. The most effective was group of salicylthioamid derivates. Substances T5619 and T5621 took...
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Márová, Marie. „Vyhodnocení aktivity potenciálně antibiotických látek pomocí mikrodiluční bujónové metody I“. Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-308236.
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Author: Marie Márová Supervisor: Ing. Lucie Křivčíková Title of diploma thesis: Evaluation of activity of potentional antibiotic substances through the use of microdilution broth method I Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study program: Pharmacy The aim of our thesis was to evaluate activity of potentially antibiotic substances on eight bacteria strains. We have tested 42 substances, all of them were synthesized at the Department of Inorganic And Organic Chemistry of Faculty of Pharmacy in Hradec Králové. We have used the microdilution broth method for the evaluation. It is a standardize procedure for finding the minimal inhibitive concentration (MIC) of antibiotics (ATB) and thereby the quantitative sensitivity of bacteria to ATB. The principle of the method is the visual readout and evaluation of bacterial growth in wells of microtiter plate. The wells were filled with a live broth, an antibiotic substance and a microbe. The antibiotic effect of the substance was evaluated positive if it came to the visible inhibition of microbial growth in the well. We have tested derivative of sulphonamides and salicylanilides. The substances were divided into 13 groups according to their structure. We have recorded the highest effect by derivatives N-phenyl-2-hydroxybenzamide,...
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Poučová, Michaela. „Vyhodnocení aktivity potenciálně antimykotických látek pomocí mikrodiluční bujónové metody II“. Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-309353.
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Poučová Michaela Evaluation of activity of potentional antifungal substances through the use of microdilution broth method II Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Specialist in laboratory methods The main concern of this study was to test potential antifungal agents and evaluate their activities. During the experiment were tested two groups of compounds, derivatives pyrazin-2-carboxamide and salicylanilide. Using microdilution broth method were measured the activities of these substances against eight strains of filamentous fungi and yeasts, which included C. albicans, C. tropicalis, C. krusei, C. glabrata, T. beigelii, A. fumigatus, A. corymbifera and T. mentagrophytes. For determining the sensitivity of these strains of fungi against tested substances was prepared eleven different concentrations (500 mol∙l-1 , 250 mol∙l-1 , 125 mol∙l-1 , 62,5 mol∙l-1 , 31, 25 mol∙l-1 , 15,625 mol∙l-1 , 7,813 mol∙l-1 , 3,906 mol∙l-1 , 1,953 mol∙l-1 , 0,977 mol∙l-1 and 0,488 mol∙l-1 ), which let incubate with the fungi. Performing microdilution broth method was determined the minimum inhibitory concentration (MIC), whose value indicates the lowest concentration of test substance that causes visible suppression of growth of yeasts or filamentous fungi. Based on the...
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Pašková, Barbora. „Vyhodnocení aktivity potenciálně antimykotických látek pomocí mikrodiluční bujónové metody IV“. Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-334691.
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Barbora Pašková Evaluation of the activity of potentional antimycotic substances through the use of microdilution broth method IV Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study program: Pharmacy Background: The aim of this diploma thesis was to evaluate the antimycotic activity of 34 substances prepared at the Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Králové of the Charles University in Prague. Methods: The substances were tested by the microdilution broth method at eight strains of yeasts and filamentous fungi. The tested substances were divided into five groups according to their chemical structure: benzylamino substituted derivates of pyrazine-2- carboxamide, aliphatic aminoderivates of pyrazine-2,3-dicarbonitrile, cyclic aminoderivates of pyrazine-2,3-dicarbonitrile, aliphatic aminoderivates of pyrazine -2-carboxamide, cyclic aminoderivates of pyrazine-2-carboxamide. Results: The highest antimycotic activity was discovered in group of cyclic aminoderivates of pyrazine-2-carboxamide, especially in tested substances OJ101 and OJ103, which showed antimycotic activity to all of strains of yeast and filamentous fungi. On the other hand, substances of group of benzylamino substituted derivates of...
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Petlánová, Tereza. „Vyhodnocení aktivity potenciálně antibiotických látek pomocí mikrodiluční bujónové metody III“. Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-334694.
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Charles Univerzity in Prague Faculty of Pharmacy in Hradec Králové Study program: Pharmacy Author: Tereza Petlánová Supervisor: Mgr. Klára Konečná, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antibiotic substances through the use of microdilution broth method III Background: The aim of this thesis was to test antibiotic substances produced by the Department of Pharmaceutical Chemistry and Drug control Faculty of Pharmacy of Charles University in Hradec Králové. Methods: Substances were tested by using microdilution broth method on eight strains of bacteria: Staphylococcus aureus, Staphylococcus aureus methicilin resistant, Staphylococcus epidermidis, Enterococcus sp., Escherichia coli, Klebsiella pneumoniae, Klebsiella pneumoniae ESBL positive and Pseudomonas aeruginosa. Results: Substances were divided into five groups according to common structural features. The most effective was group of aliphatic derivates of pyrazine-2,3-dicarbonitrile. A groups of cyclic derivates of pyrazine-2,3-dicarbonitrole and cyclic derivates of pyrazine-2- carboxamide were almost ineffective. Conclusion: Of the total of 34 tested compounds was observed antibacterial effect in 13 of them. The most susceptible strains were Enterococcus sp., Straphylococcus aureus and Staphylococcus epidermidis....
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PRŮŠOVÁ, Milena. „Využití nových statistických postupů při vyhodnocení projekce KPÚ v Jihočeském kraji“. Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-53333.
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The thesis deals with evaluation of the projection of complex agrarian arrangement in a selected test set represented by the region of South Bohemia The theoretical part focuses on goals and financial measures of the land consolidation in coherence with the financial support programs. Furthermore, it mentiones some of the primary issues, for example the plan of joint facilities and field routes. The practical part determines the appropriate methods and sets leading to obtaining results both in written and in graphic form. Based on data from the districts of South Bohemia we will a) assess and compare the current state of projection with the percentage of both started and completed complex land arrangements in individual districts, b) asses the main reasons for the implementing these arrangements, c) asses the fragmentation of land in relation to land consolidation and d) asses the costs of land consolidation in individual districts. The goal of this thesis is to provide a comprehensive analysis of projected land arrangements and possible suggestions to improve the current state.