Auswahl der wissenschaftlichen Literatur zum Thema „Methylerythritol phosphate pathway (MEP pathway)“
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Zeitschriftenartikel zum Thema "Methylerythritol phosphate pathway (MEP pathway)"
Banerjee, A., und T. D. Sharkey. „Methylerythritol 4-phosphate (MEP) pathway metabolic regulation“. Nat. Prod. Rep. 31, Nr. 8 (2014): 1043–55. http://dx.doi.org/10.1039/c3np70124g.
Der volle Inhalt der QuelleTesta, Charles A., und L. Jeffrey Johnson. „A Whole-Cell Phenotypic Screening Platform for Identifying Methylerythritol Phosphate Pathway-Selective Inhibitors as Novel Antibacterial Agents“. Antimicrobial Agents and Chemotherapy 56, Nr. 9 (09.07.2012): 4906–13. http://dx.doi.org/10.1128/aac.00987-12.
Der volle Inhalt der QuelleCassera, María B., Fabio C. Gozzo, Fabio L. D'Alexandri, Emilio F. Merino, Hernando A. del Portillo, Valnice J. Peres, Igor C. Almeida et al. „The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages ofPlasmodium falciparum“. Journal of Biological Chemistry 279, Nr. 50 (27.09.2004): 51749–59. http://dx.doi.org/10.1074/jbc.m408360200.
Der volle Inhalt der QuelleChen, Lijia, Hui Tong, Mingxuan Wang, Jianhua Zhu, Jiachen Zi, Liyan Song und Rongmin Yu. „Effect of Enzyme Inhibitors on Terpene Trilactones Biosynthesis and Gene Expression Profiling in Ginkgo biloba Cultured Cells“. Natural Product Communications 10, Nr. 12 (Dezember 2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001205.
Der volle Inhalt der QuelleZeidler, J., J. Schwender, C. Mueller und H. K. Lichtenthaler. „The non-mevalonate isoprenoid biosynthesis of plants as a test system for drugs against malaria and pathogenic bacteria“. Biochemical Society Transactions 28, Nr. 6 (01.12.2000): 796–98. http://dx.doi.org/10.1042/bst0280796.
Der volle Inhalt der QuelleKadian, Kavita, Yash Gupta, Harsh Vardhan Singh, Prakasha Kempaiah und Manmeet Rawat. „Apicoplast Metabolism: Parasite’s Achilles’ Heel“. Current Topics in Medicinal Chemistry 18, Nr. 22 (10.01.2019): 1987–97. http://dx.doi.org/10.2174/1568026619666181130134742.
Der volle Inhalt der QuelleCornish, Rita M., John R. Roth und C. Dale Poulter. „Lethal Mutations in the Isoprenoid Pathway of Salmonella enterica“. Journal of Bacteriology 188, Nr. 4 (15.02.2006): 1444–50. http://dx.doi.org/10.1128/jb.188.4.1444-1450.2006.
Der volle Inhalt der QuellePérez-Gil, Jordi, und Manuel Rodríguez-Concepción. „Metabolic plasticity for isoprenoid biosynthesis in bacteria“. Biochemical Journal 452, Nr. 1 (25.04.2013): 19–25. http://dx.doi.org/10.1042/bj20121899.
Der volle Inhalt der QuelleBanerjee, Aparajita, Yan Wu, Rahul Banerjee, Yue Li, Honggao Yan und Thomas D. Sharkey. „Feedback Inhibition of Deoxy-d-xylulose-5-phosphate Synthase Regulates the Methylerythritol 4-Phosphate Pathway“. Journal of Biological Chemistry 288, Nr. 23 (23.04.2013): 16926–36. http://dx.doi.org/10.1074/jbc.m113.464636.
Der volle Inhalt der QuelleKilliny, Nabil. „Silencing Phytoene Desaturase Causes Alteration in Monoterpene Volatiles Belonging to the Methylerythritol Phosphate Pathway“. Plants 11, Nr. 3 (20.01.2022): 276. http://dx.doi.org/10.3390/plants11030276.
Der volle Inhalt der QuelleDissertationen zum Thema "Methylerythritol phosphate pathway (MEP pathway)"
Bianchino, Gabriella ines. „La métalloenzyme IspH, une source pour la découverte de nouveaux agents antimicrobiens“. Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF016.
Der volle Inhalt der QuelleOne way to tackle the arising antimicrobial resistance is to focus on underexploited series of target enzymes. In most bacteria and some parasites, the isoprenoid precursors are synthesized via the 2C-methyl-d-erythritol 4-phosphate (MEP) pathway, which is absent in humans, and it thus represents an interesting target for the development of novel anti-infectives. IspH is an oxidoreductase containing an oxygen-sensitive [4Fe-4S]2+ cluster that catalyzes the last step of the MEP pathway converting HMBPP into IPP and DMAPP. A multidisciplinary strategy has been applied for the discovery of new classes of inhibitors against IspH from Pseudomonas aeruginosa, Mycobacterium tuberculosis and Plasmodium falciparum. A method was developed to produce the IspH orthologs as holoenzymes, followed by the development of the enzymatic assay which was used for an in vitro screening campaign of different chemical libraries. The latter led to the discovery of a novel potent inhibitor targeting the three orthologs object of this study. Moreover, a prodrug approach has been exploited for an already known E. coli IspH inhibitor ((E)-4-amino-3-methylbut-2-en-1-yl diphosphate) with the goal of reaching antibacterial, antitubercular, and antimalarial activity
Baatarkhuu, Zoljargal. „Metabolic labelling of bacterial isoprenoids produced by the methylerythritol phosphate pathway : a starting point towards a new inhibitor“. Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF029/document.
Der volle Inhalt der QuelleIsoprenoids, present in all living organisms, are synthesised according to two routes: the Mevalonate and the Methylerythritol phosphate (MEP) pathways. The MEP pathway, absent in humans, is extensively investigated as it is a target for the development of new antimicrobials. ME-N3 an azide tagged analogue of methylerythritol was synthesised and utilised for metabolic labelling studies of the MEP pathway using bioorthogonal ligation followed by LC-MS analysis. Interestingly, we found that MEP-N3, an analogue of MEP, inhibits E.coli IspD (3rd enzyme of the MEP pathway). Further inhibition kinetic studies revealed that MEP-N3 possesses the highest inhibitory activity on E.coli ispD when compared to known inhibitors. In addition, the mechanism of inhibition of E.coli ispD by MEP-N3 was found to be best described using a mixed type model. Moreover, determination of the IspD reaction mechanism has been carried out for the first time, by virtue of a bisubstrate steady state kinetic analysis
Henriksson, Lena M. „Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis“. Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8253.
Der volle Inhalt der QuelleGiménez, Oya Víctor. „Molecular studies of two methylerythritol 4-phosphate pathway enzymes of isoprenoid biosynthesis : the 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and the 1-deoxy-D-xylulose 5-phosphate synthase = Estudios moleculares de dos enzimas de la ruta del metileritritol 4-fosfato de biosíntesis de isoprenoides : la 4-difosfocitidil-2C-metil-D-eritritol quinasa y la 1-dexosi-D-xilulosa 5-fosfato sintasa“. Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/665005.
Der volle Inhalt der QuelleJansson, Anna M. „Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis“. Doctoral thesis, Uppsala universitet, Struktur- och molekylärbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196623.
Der volle Inhalt der QuelleBuchteile zum Thema "Methylerythritol phosphate pathway (MEP pathway)"
Lichtenthaler, Hartmut K. „Chapter 7 The Non-mevalonate DOXP/MEP (Deoxyxylulose 5-Phosphate/Methylerythritol 4-Phosphate) Pathway of Chloroplast Isoprenoid and Pigment Biosynthesis“. In The Chloroplast, 95–118. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8531-3_7.
Der volle Inhalt der QuelleBoronat, Albert. „Chapter 8 The Methylerythritol 4-Phosphate Pathway: Regulatory Role in Plastid Isoprenoid Biosynthesis“. In The Chloroplast, 119–26. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8531-3_8.
Der volle Inhalt der QuelleSathee, Lekshmy, M. K. Malini, Pramod Kumar und Sudhir Kumar. „Terpenoid Production Through Mevalonate and Methylerythritol Phosphate Pathway and Regulation of Environmental Stress Tolerance“. In Biology and Biotechnology of Environmental Stress Tolerance in Plants, 67–100. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003346173-4.
Der volle Inhalt der QuelleNagegowda, Dinesh A., David Rhodes und Natalia Dudareva. „Chapter 10 The Role of the Methyl-Erythritol-Phosphate (MEP)Pathway in Rhythmic Emission of Volatiles“. In The Chloroplast, 139–54. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8531-3_10.
Der volle Inhalt der QuelleWright, Louwrance P., und Michael A. Phillips. „Measuring the Activity of 1-Deoxy-D-Xylulose 5-Phosphate Synthase, the First Enzyme in the MEP Pathway, in Plant Extracts“. In Methods in Molecular Biology, 9–20. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0606-2_2.
Der volle Inhalt der QuelleO. Bruce, Stella, und Felix A. Onyegbule. „Biosynthesis of Natural Products“. In Biosynthesis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97660.
Der volle Inhalt der Quelle„Mevalonate and Methylerythritol Phosphate Pathways: Terpenoids and Steroids“. In Chemical Diversity of Plant Specialized Metabolites, 77–162. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671472-00077.
Der volle Inhalt der QuelleBittencourt Fagundes, Mariane, und Roger Wagner. „Sterols Biosynthesis in Algae“. In Biosynthesis [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96719.
Der volle Inhalt der QuelleRohmer, Michel. „Methylerythritol Phosphate Pathway“. In Comprehensive Natural Products III, 560–90. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-08-102690-8.00702-8.
Der volle Inhalt der QuelleRohmer, Michel. „Methylerythritol Phosphate Pathway“. In Comprehensive Natural Products II, 517–55. Elsevier, 2010. http://dx.doi.org/10.1016/b978-008045382-8.00702-4.
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