Auswahl der wissenschaftlichen Literatur zum Thema „Mélanges de contaminants“
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Zeitschriftenartikel zum Thema "Mélanges de contaminants"
Ghozal, M., M. Kadawathagedara, R. Delvert, A. Divaret-Chauveau, C. Raherison, M. A. Charles, K. Adel-Patient und B. De Lauzon-Guillain. „Association entre exposition prénatale par voie alimentaire à des mélanges de contaminants chimiques et allergies et santé respiratoire jusqu’à 5,5 ans“. Revue Française d'Allergologie 64 (April 2024): 103892. http://dx.doi.org/10.1016/j.reval.2024.103892.
Der volle Inhalt der QuelleBoutin, Élaine, Jean-François Blais, Guy Mercier, Patrick Drogui und Myriam Chartier. „Valorisation de coproduits de l’industrie agro-alimentaire par production de compost de haute qualitéArticle envoyé à la Revue du génie et de la science de l'environnement.“ Canadian Journal of Civil Engineering 37, Nr. 1 (Januar 2010): 156–66. http://dx.doi.org/10.1139/l09-112.
Der volle Inhalt der QuelleImano, Adolphe Moukengué. „Rigidité diélectrique d'un interface gazsupport avec contaminant métallique dans l'air sec et ses mélanges avec le SF6“. Canadian Journal of Physics 84, Nr. 5 (01.05.2006): 381–98. http://dx.doi.org/10.1139/p06-061.
Der volle Inhalt der QuelleGALTIER, P., I. P. OSWALD, P. GUERRE, D. MORGAVI, H. BOUDRA und J. P. JOUANY. „Le risque mycotoxique : danger et impact sanitaire en productions animales“. INRAE Productions Animales 21, Nr. 1 (20.03.2008): 107–16. http://dx.doi.org/10.20870/productions-animales.2008.21.1.3381.
Der volle Inhalt der QuelleLeclerc, M., und P. Boudreault. „Méthodologie d'analyse détaillée de la contamination par tronçon du fleuve Saint-Laurent par modélisation numérique : le cas du lac Saint-Pierre“. Revue des sciences de l'eau 6, Nr. 4 (12.04.2005): 427–52. http://dx.doi.org/10.7202/705184ar.
Der volle Inhalt der QuelleLe Magueresse, B., H. Vidal und D. Naville. „Impact d’une exposition chronique à un mélange de contaminants alimentaires faiblement dosés ; mise en évidence d’effets dépendants du sexe dans un modèle de souris obèses“. Annales d'Endocrinologie 75, Nr. 5-6 (Oktober 2014): 249. http://dx.doi.org/10.1016/j.ando.2014.07.868.
Der volle Inhalt der QuelleDELPY, Floriane, Yves LUCAS, Gilles BARATTO, Emmanuel PLESSIS und Patricia MERDY. „Écotoxicité des nanoplastiques vis-à-vis d’organismes tels que les rotifères“. TSM 12 2023, TSM 12 2023 (20.12.2023): 51–70. http://dx.doi.org/10.36904/tsm/202312051.
Der volle Inhalt der QuelleCouillard, Catherine M. „Utilisation des poissons pour évaluer les effets biologiques des contaminants dans l’estuaire du Saint-Laurent et le fjord du Saguenay“. 22, Nr. 2 (15.06.2009): 291–314. http://dx.doi.org/10.7202/037486ar.
Der volle Inhalt der QuelleLee, Seokjae, Subin Yang, Dongjoon Lee, Hangseok Choi und Jongmuk Won. „Transport du bleu de méthylène dans un mélange de sable et d'illite et ses implications pour le transport des contaminants“. Hydrogeology Journal, 06.06.2023. http://dx.doi.org/10.1007/s10040-023-02647-0.
Der volle Inhalt der QuelleBelli, Nassima, Lahouel Mesbah, Samira Chebab, Mustafa Tekouk und Essaid Leghouchi. „Stress oxydant induit par la coexposition au plomb et au cadmium : deux contaminants des eaux souterraines de Oued Nil (Jijel - Algérie)“. 23, Nr. 3 (25.10.2010): 289–301. http://dx.doi.org/10.7202/044690ar.
Der volle Inhalt der QuelleDissertationen zum Thema "Mélanges de contaminants"
Kopp, Benjamin. „Nouvelles approches en toxicologie prédictive pour l'étude de la toxicité des mélanges de contaminants présents dans l'alimentation française“. Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30208.
Der volle Inhalt der QuelleThrough diet, people are exposed simultaneously to a variety of contaminants that could have combined adverse effects on human health. Six food contaminant mixtures to which the French population is exposed were defined based on individual food consumption data and data on the concentration of chemicals in foodstuff. The purpose of this work was to investigate the genotoxic effects of mixtures in vitro using novel approaches. We demonstrated that two mixtures could be genotoxic and mutagenic, at concentrations for which each individual compound did not induce any DNA damage, suggesting that the combined effect was not additive. We also concluded that, for the two mixtures, the effects were driven by two heavy metals and displayed a great synergy. Finally, we achieved our work by providing detailed information on the mechanisms of action of mixtures to better understand interaction
Savary, Camille. „Étude de la toxicité chronique et du potentiel cancérogène de contaminants de l’environnement séparément et en mélange sur les cellules HepaRG“. Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1B007/document.
Der volle Inhalt der QuelleHumans are exposed throughout their life to many environmental and food contaminants, usually at low doses and in mixtures. Risk assessment remains questionable as it is well established that there are differences in the response to chemicals between humans and animals. Regardless of the route of exposure, due to its major role in xenobiotic biotransformation, the liver is considered as a target organ for many classes of chemicals potentially cytotoxic, genotoxic or carcinogenic. We used the HepaRG cell line to evaluate chronic toxicity and/or carcinogenicity of pesticides and genotoxic compounds. This cell line is the only one known to exhibit properties similar to those of human hepatocytes in primary culture. In the first part we confirmed the maintenance of functional capacities of these cells at confluence by transcriptomic and biokinetic analysis of several drugs after a 14-day treatment. We then investigated the effects of mixtures of pesticides after acute and repeated exposures. We showed that : 1. Isomalathion, a major impurity of malathion, played a leading role on liver toxicity and inhibited carboxylesterase that is involved in the metabolism of these two compounds; 2. Endosulfan and methoxychlor, two organochlorines, metabolized by CYP3A4 and CYP2B6, acted synergistically on their cytotoxicity after single or repeated exposure. Moreover, whereas activity of CYP3A4 was reversibly inhibited by endosulfan and increased by methoxychlor. By contrast, CYP2B6 activity was induced by these two pesticides while in equimolar mixtures, they caused additive or antagonistic effects on CYP3A4 and CYP2B6 activities respectively, regardless of the duration of exposure. Finally, in the third part, we exposed HepaRG cells for up to 15 passages to low doses of two genotoxic contaminants which required bioactivation, aflatoxin B1 and heterocyclic aromatic amine, PhIP, and demonstrated the appearance of properties of transformed cells (e.g. growth on agar, cell migration in the wound healing test and overexpression of a number of genes associated with cancer). Altogether, our results demonstrate the great potential interest that represents the metabolically competent human liver cell line HepaRG for the study of chronic toxicity and/or carcinogenic potential of environmental contaminants. They highlight possible interactions between pesticides in binary mixtures and for the first time, demonstrate that the carcinogenic potential of genotoxic contaminants can be analyzed in an human hepatic cell line
Pouchoulin, Sébastien. „Mélange des eaux à l'aval d'une confluence : Amélioration de la modélisation des flux de contaminant dans les cours d'eau et les réseaux d'assainissement“. Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEI124.
Der volle Inhalt der QuelleThe thesis focuses on the mixing of two free surface flows downstream of their confluence. The operational goal is to better parameterize the mixing in the modeling of dissolved and particulate pollutant fluxes in watercourses and sewer networks. The scientific objectives are to explain the great disparities observed in the literature on the effectiveness of this mixture, in particular by proposing a law including the geometric and hydraulic parameters of the confluence. The work has three components. The first is based on field experiments at the Rhône-Saône confluence. It shows that a sudden vertical stratification can occur under certain hydraulic conditions. In the absence of this one, conventional formulations averaged on the vertical and based on a transverse mixing coefficient correctly model the mixing. The second component uses laboratory experiments, with an original concentration measurement technique that can be used in a closed circuit, thus providing a precise database. The third component is a parametric study based on 3D hydrodynamic numerical simulations. It highlights the role of the main parameters that are: the momentum ratio of the upstream tributaries, the angle of the junction and the width / depth ratio. The results make it possible to explain the large disparities reported over the length necessary to reach the mixture downstream of a confluence. Parameterization, based on a transverse mixing coefficient, is now available
Andriamalala, Aurore. „Antibiotiques apportés seuls ou en mélange (antibiotique+antibiotique et antibiotique+métaux) dans des sols agricoles – Devenir et impacts sur les microorganismes du sol et leurs activités“. Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLA022/document.
Der volle Inhalt der QuelleThe antibiotics (ATB) used in human and veterinary medicine are largely excreted and can enter agricultural soils through the spreading of organic waste products (OWP), with unassessed risks on human health and the environment. In addition, these ATBs are most often combined with other organic and / or mineral contaminants. However, very few studies have addressed the fate and effects of ATBs interacting with other contaminants in soils.The objective of the thesis was to better understand the fate of ATB applied to soils alone or in combination with other contaminants, and their impacts on soil microorganisms and their activities.The antibiotics selected were sulfamethoxazole (SMX) and ciprofloxacin (CIP), for their contrasting mode of action and behavior, and N-ac-SMX, the main metabolite of SMX. The chosen metals were copper and zinc, which are known to increase in soils with regular applications of certain OWPs. They were brought together, at an environmental dose, and at a dose 5 times higher. The soils are a control soil that has never received OWP and two soils amended since 1998, by manure or compost green waste and sewage sludge, to test the impact of repeated applications of OWP and of the nature of OWP.Microcosms were incubated under controlled conditions for 156 days. For the study of ATB fate, the soils were treated with 14C-labeled ATBs and the 14C distribution was followed in the mineralized, easily and hardly extractable and non-extractable fractions. The impact of ATBs alone or in combinations on microorganisms and their activities was studied using unlabelled ATBs.The fate of ATBs is controlled by :i) The nature and properties of ATBs: CIP is rapidly and strongly adsorbed in soils and is not mineralized. Sulfonamides are rapidly degraded and mineralized up to 10% after 156 days.The fates of the SMX and N-ac-SMX are almost similar when they are brought alone, the N-ac-SMX being transformed into SMX. Whatever the molecules, the non-extractable residues are major at the end of incubation (> 50%).ii) Previous repeated applications of OWP that enhance adsorption of ATBs and reduce their mineralization.iii) The nature of the OWP : the more stable compost promotes the production of hardly extractable residues, the manure, more degradable, stimulates the mineralization of the sulfonamides and the production of non-extractable residues.iv) The presence of other contaminants, their nature and concentration : although the CIP at environmental doses did not affect the fate of SMX and N-ac-SMX in soils, the influence of metals was measurable and increased with their dose. At low doses, metals decrease the mineralization of SMX and N-ac-SMX by a factor of 2, by promoting the adsorption of ATBs through complexation, in particular with copper. At high doses, metals inhibit the mineralization of sulfonamides, through physicochemical reactions (increased adsorption of ATBs via copper) and certainly biological effects (toxic effects especially of zinc).The sulfonamides had no effect on soil microorganisms and mineralization of carbon and nitrogen when applied alone or as a mixture with ciprofloxacin or metals at environmental doses. But mixtures with the high dose of metals induce toxic effects on microbial biomass and mineralization of carbon. These toxic effects seem mainly due to metals and not to pH or ionic strength indirect effects.Therefore under these experimental conditions, the environmental risks associated with ATBs seem limited in the short term. But it would be necessary to study the effects in the longer term and of cumulative applications
Legrand, Eléna. „Couplage d’approches écotoxicogénomiques chez le copépode estuarien Eurytemora affinis et d’outils bio-analytiques pour l’évaluation du caractère perturbateur endocrinien des contaminants aquatiques : exemple de deux pesticides modèles : le pyriproxyfène et la chlordécone, seuls et en mélange“. Thesis, Le Havre, 2016. http://www.theses.fr/2016LEHA0007/document.
Der volle Inhalt der QuelleAquatic ecosystems constitute the chemicals’ final destination. Among the xenobiotics, endocrine disruptors (ED) are compounds of major concern. In this context, ED pesticides effects were investigated in the widespread copepod Eurytemora Affinis using ecotoxicogenomics technics. In response to PE pesticides, focus was made on reproduction, growth and development. In order to evaluate the endocrine activity, in vitro tests (YES/YAS/anti-YES/anti-YAS and S2 EcR) were used to screen the compounds alone and in mixtures. These results were discussed to evaluate the “cut off criterion” used in European assessment. This work presents for the first time, transcriptomes and proteomes of E. affinis after PXF and CLD –alone and in binary mixture- exposure. A sex dependent effect was observed by the two “omics” approaches. Male copepods were more impacted by contaminants than female copepods. Genes and proteins (e.g. chitin deacetylase, kelch protein) were identified as candidates for the development of ED molecular biomarkers. In vitro tests highlighted binding of pesticides with both vertebrate and invertebrate receptors. However, a toxicity for the highest concentrations tested and some limits for the interpretation of mixtures results were limiting in YES/YAS/anti-YES/anti-YAS assays. The last observation represents particularly a major concern for interpretation of the ED mode of action of environmental matrix. S2 EcR highlighted some complementary results about the mode of action of chemicals alone and in binary mixtures. These results accentuate the need to combine vertebrate specific test and invertebrate specific test in ED risk assessment