Thematische Bibliographien / Mechanoception

Auswahl der wissenschaftlichen Literatur zum Thema „Mechanoception“

Autor: Grafiati

Veröffentlicht am 27. Juli 2024

Zuletzt aktualisiert am 29. Juli 2024

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Zeitschriftenartikel zum Thema "Mechanoception"

Yu, Jack C., Jaclyn M. Yu, Dhairya Shukla, Maria H. Lima, Atbin Doroodchi, Gustavo Munoz Monaco und Babak Baban. „Pain and Management of Pain: A Clinical Review for Craniofacial Surgeons“. FACE 2, Nr. 2 (09.05.2021): 131–39. http://dx.doi.org/10.1177/27325016211009271.

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Frequently, aches, and pain are symptoms, like alarms alerting the occurrences of dangerous events which can cause cell death, tissue destruction, and inflammation. Physicians treat the underlying diseases which cause the pain and aches in order to restore health. On some occasions, the treatments are directed at aches and pains themselves, and are thus symptomatic relief. For surgeons, pain is an inevitable consequence of what we do in the operating room. Postoperative pain management represents an important part of the Enhanced Recovery After Surgery (ERAS) protocols. Furthermore, opioid epidemic has cost a great burden on the society and the healthcare system, which also places an emphasis on using non-opioid analgesics to achieve adequate pain relief. Unlike other vital signs, there is no objective, direct measurement of pain, even though pain is considered the fourth vital sign. Pain is a perceived sensation, as a result of nociception, a complex process which can extend from other somatosensory modalities such as thermoception, chemoception, and mechanoception. Whenever the stimulus magnitude exceeds nominal physiologic boundaries, cell death, and tissue injury follow, as does afferent nociceptive signals. This review is to provide craniofacial surgeons with an update on pain, what pain is, how to assess it, pharmacology of pain relief, and specifically, the proper use of opioids and non-narcotic analgesic agents. The goal is to allow for the optimal, rational use of these medications to relief pain with the minimum short and long term risks. With evidence-based, data-driven approach, supplemented by group experience pooled from senior surgeons after 100,000 patient-hours, the objective is to answer the following: (1) What is pain? (2) How does opioid work? (3) What is the role of narcotic analgesics in craniofacial ERAS? (4) When should non-opioids be used and how?

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Macchi, Chiara, Veronica Bonalume, Maria Francesca Greco, Marta Mozzo, Valentina Melfi, Cesare R. Sirtori, Valerio Magnaghi, Alberto Corsini und Massimiliano Ruscica. „Impact of Atorvastatin on Skeletal Muscle Mitochondrial Activity, Locomotion and Axonal Excitability—Evidence from ApoE-/- Mice“. International Journal of Molecular Sciences 23, Nr. 10 (12.05.2022): 5415. http://dx.doi.org/10.3390/ijms23105415.

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The cardiovascular benefit of statins is well established. However, only 20% of high-risk patients remain adequately adherent after 5 years of treatment. Among reasons for discontinuation, statin associated-muscle pain symptoms are the most prevalent. Aim of the present study was to evaluate the impact of high dose atorvastatin on skeletal muscle mitochondrial activity, aerobic and anaerobic exercise, and axonal excitability in a murine model of atherosclerosis. ApoE-/- mice were fed 12 weeks a high-fat high-cholesterol diet alone or containing atorvastatin (40 mg/Kg/day). Outcomes were the evaluation of muscle mitochondrial functionality, locomotion, grip test, and axonal excitability (compound action potential recording analysis of Aα motor propioceptive, Aβ mechanoceptive and C nociceptive fibres). Atorvastatin led to a reduction in muscle mitochondrial biogenesis and mitochondrial ATP production. It did not affect muscular strength but led to a time-dependent motor impairment. Atorvastatin altered the responsiveness of mechanoceptive and nociceptive fibres, respectively, the Aβ and C fibres. These findings point out to a mild sensitization on mechanical, tactile and pain sensitivity. In conclusion, although the prevalence of muscular side effects from statins may be overestimated, understanding of the underlying mechanisms can help improve the therapeutic approach and reassure adherence in patients needing-to-be-treated.

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Scelsi, Daniele, Niccolò Mevio, Giulia Bertino, Antonio Occhini, Valeria Brazzelli, Patrizia Morbini und Marco Benazzo. „Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region“. Radiology and Oncology 47, Nr. 4 (01.12.2013): 366–69. http://dx.doi.org/10.2478/raon-2013-0059.

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Abstract Background. Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. Case report. We report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life. Conclusions. Our case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

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Wasner, G., R. Baron und W. Jänig. „Dynamic mechanical allodynia is not mediated by a central presynaptic interaction of aβ-mechanoceptive and nociceptive c-afferents“. Pathophysiology 5 (Juni 1998): 168. http://dx.doi.org/10.1016/s0928-4680(98)80943-7.

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Zhang, Shi-Hong, Qi-Xin Sun, Ze’ev Seltzer, Dong-Yuan Cao, Hui-Sheng Wang, Zhong Chen und Yan Zhao. „Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors“. Brain Research Bulletin 75, Nr. 1 (Januar 2008): 138–45. http://dx.doi.org/10.1016/j.brainresbull.2007.08.003.

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Chiang, C. Y., J. W. Hu und B. J. Sessle. „Parabrachial area and nucleus raphe magnus-induced modulation of nociceptive and nonnociceptive trigeminal subnucleus caudalis neurons activated by cutaneous or deep inputs“. Journal of Neurophysiology 71, Nr. 6 (01.06.1994): 2430–45. http://dx.doi.org/10.1152/jn.1994.71.6.2430.

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1. The aim of this study was to test whether parabrachial area (PBA) stimulation exerts inhibitory influences on the spontaneous activity and responses evoked by skin and deep afferent inputs in trigeminal subnucleus caudalis (Vc) neurons, and to compare these effects with those of nucleus raphe magnus (NRM) stimulation. A total of 92 nonnociceptive and nociceptive Vc neurons was recorded in urethan/alpha-chloralose-anesthetized rats. Each neuron was functionally classified as low-threshold mechanoceptive (LTM), wide dynamic range (WDR), nociceptive-specific (NS), nociceptive convergent with both skin and deep inputs (S+D), or deep nociceptive (D); the LTM neurons could be subdivided as rapidly adapting (RA) or slowly adapting (SA). Conditioning stimulation was applied to histologically verified sites in PBA and NRM. 2. The spontaneous or evoked activity of all classes of neurons could be inhibited by PBA as well as by NRM stimulation, but generally the incidence and magnitude of inhibition were lower for the LTM neurons. Occasionally, facilitation of neuronal activity was also produced by PBA and NRM stimulation. 3. The spontaneous activity of 11 LTM neurons (6 RA, 5 SA), 13 nociceptive neurons (6 WDR, 7 NS), and 5 D neurons was tested with stimulation of PBA or NRM or both. LTM spontaneous activity was more significantly inhibited by NRM stimulation than by PBA stimulation, whereas both NRM and PBA stimulation had similar and significant inhibitory effects on NS, WDR, and D neurons. 4. The evoked nonnociceptive responses of 28 LTM neurons (16 RA, 12 SA) and of 6 WDR neurons were also tested with stimulation of PBA or NRM or both. The magnitudes of inhibition of the responses produced by PBA conditioning stimulation were statistically significantly less than those induced by NRM conditioning stimulation. 5. The cutaneous and deep nociceptive responses of cutaneous nociceptive neurons (9 NS, 19 WDR) and seven D neurons, respectively, were also tested with PBA and NRM stimulation. There was a significant difference in potency between PBA- and NRM-induced inhibition, but no difference in the magnitude of inhibitory effects among NS, WDR, and D neurons. For both PBA and NRM conditioning stimulation, graded increases in intensities of stimulation produced linear increases in inhibitory effects on nociceptive responses; an increase in stimulation frequency from 5 to 400 Hz also produced increases in inhibition of the nociceptive responses. 6. In five S+D nociceptive convergent neurons, the responses elicited by deep inputs were more powerfully inhibited by PBA stimulation than those elicited by cutaneous inputs.(ABSTRACT TRUNCATED AT 400 WORDS)

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Redaelli, Veronica, Alice Bosi, Fabio Luzi, Paolo Cappella, Pietro Zerbi, Nicola Ludwig, Daniele Di Lernia et al. „Neuroinflammation, body temperature and behavioural changes in CD1 male mice undergoing acute restraint stress: An exploratory study“. PLOS ONE 16, Nr. 11 (15.11.2021): e0259938. http://dx.doi.org/10.1371/journal.pone.0259938.

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Background Animal models used to study pathologies requiring rehabilitation therapy, such as cardiovascular and neurologic disorders or oncologic disease, must be as refined and translationally relevant as possible. Sometimes, however, experimental procedures such as those involving restraint may generate undesired effects which may act as a source of bias. However, the extent to which potentially confounding effects derive from such routine procedures is currently unknown. Our study was therefore aimed at exploring possible undesirable effects of acute restraint stress, whereby animals were exposed to a brightly lit enclosed chamber (R&L) similar to those that are commonly used for substance injection. We hypothesised that this would induce a range of unwanted physiological alterations [such as neuroinflammatory response and changes in body weight and in brown adipose tissue (BAT)] and behavioural modification, and that these might be mitigated via the use of non-aversive handling methods: Tunnel Handling (NAH-T) and Mechanoceptive Handling (NAH-M)) as compared to standard Tail Handling (TH). Methods Two indicators of physiological alterations and three potentially stress sensitive behavioural parameters were assessed. Physiological alterations were recorded via body weight changes and assessing the temperature of Brown Adipose Tissue (BAT) using infra-red thermography (IRT), and at the end of the experiment we determined the concentration of cytokines CXCL12 and CCL2 in bone marrow (BM) and activated microglia in the brain. Nest complexity scoring, automated home-cage behaviour analysis (HCS) and Elevated Plus Maze testing (EPM) were used to detect any behavioural alterations. Recordings were made before and after a 15-minute period of R&L in groups of mice handled via TH, NAH-T or NAH-M. Results BAT temperature significantly decreased in all handling groups following R&L regardless of handling method. There was a difference, at the limit of significance (p = 0.06), in CXCL12 BM content among groups. CXCL12 content in BM of NAH-T animals was similar to that found in Sentinels, the less stressed group of animals. After R&L, mice undergoing NAH-T and NAH-M showed improved body-weight maintenance compared to those exposed to TH. Mice handled via NAH-M spent a significantly longer time on the open arms of the EPM. The HCS results showed that in all mice, regardless of handling method, R&L resulted in a significant reduction in walking and rearing, but not in total distance travelled. All mice also groomed more. No difference among the groups was found in Nest Score, in CCL2 BM content or in brain activated microglia. Conclusions Stress induced by a common restraint procedure caused metabolic and behavioural changes that might increase the risk of unexpected bias. In particular, the significant decrease in BAT temperature could affect the important metabolic pathways controlled by this tissue. R&L lowered the normal frequency of walking and rearing, increased grooming and probably carried a risk of low-grade neuro-inflammation. Some of the observed alterations can be mitigated by Non-aversive handlings.

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Sternberg, Jenna R., Andrew E. Prendergast, Lucie Brosse, Yasmine Cantaut-Belarif, Olivier Thouvenin, Adeline Orts-Del’Immagine, Laura Castillo et al. „Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature“. Nature Communications 9, Nr. 1 (18.09.2018). http://dx.doi.org/10.1038/s41467-018-06225-x.

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Emmi, Aron, Elena Stocco, Rafael Boscolo-Berto, Martina Contran, Elisa Belluzzi, Marta Favero, Roberta Ramonda et al. „Infrapatellar Fat Pad-Synovial Membrane Anatomo-Fuctional Unit: Microscopic Basis for Piezo1/2 Mechanosensors Involvement in Osteoarthritis Pain“. Frontiers in Cell and Developmental Biology 10 (28.06.2022). http://dx.doi.org/10.3389/fcell.2022.886604.

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The Infrapatellar Fat Pad (IFP) is a fibro-adipose tissue of the knee recently reconsidered as part of a single anatomo-functional unit (AFU) together with the synovial membrane (SM). Several evidence support the role of this unit in the mechanisms that trigger and perpetuate the onset and progression of osteoarthritis (OA) disease. Additionally, the contribution of IFP-SM AFU in OA-associated pain has also been supposed, but this assumption still needs to be fully elucidated. Within this context, the recent discovery of the mechanoceptive Piezo ion channels (i.e., Piezo1 and Piezo2) in mammals and consciousness on their role in mediating both mechanoceptive and inflammatory stimuli could shed some light on knee OA pain, as well as on the process leading from acute to chronic nociceptive responses. For this purpose, the IFP-SM AFUs of both healthy donors (non-OA IFP-SM AFUs, n = 10) and OA patients (OA IFP-SM AFUs, n = 10) were processed by histology and immunohistochemistry. After the attribution of a histopathological score to IFP-SM AFUs to confirm intrinsic differences between the two groups, the specimens were investigated for the expression and localization/distribution pattern of the mechanosensors Piezo1 and Piezo2. In addition, the presence of monocytes/macrophages (CD68), peripheral nerve endings (PGP9.5) and neoangiogenesis signs (YAP1) was evaluated for a broad tissue characterization. The study results lead to a better description of the IFP-SM AFU microscopic features in both healthy and pathological conditions, highlighting peculiar differences in the study cohort. Specifically, immunopositivity towards Piezo1/2, CD68 and YAP1 markers was detected at vessels level in the OA- IFP-SM AFUs compartments, differently from the non-OA-group. A correlation with pain was also inferred, paving the way for the identification of new and effective molecules in OA management.

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Isoardo, Gianluca, Stefano Ciullo, Paolo Titolo, Elena Fontana, Bruno Battiston, Maurizio Stella, Nicola Luxardo et al. „The relationship between alexithymia, sensory phenotype and neurophysiological parameters in patients with chronic upper limb neuropathy“. Journal of Neural Transmission, 14.12.2020. http://dx.doi.org/10.1007/s00702-020-02282-z.

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AbstractIn this study, we investigated the relationship between sensory abnormalities evaluated by quantitative sensory testing (QST) and alexithymia, depression and anxiety in patients with neuropathic pain involving the upper limbs. We enrolled 62 patients (34 with carpal tunnel syndrome, 7 with brachial plexopathy, 3 with cervical painful radiculopathy, 5 with ulnar entrapment neuropathy at elbow and 13 with post-burn hypertrophic scars) and 48 healthy controls. All underwent nerve conduction studies (NCS), evaluation of cold, heat pain and vibration detection threshold (VDT) by QST and evaluation of alexithymia by Toronto Alexithymia Scale (TAS-20), depression by Beck Depression Inventory II (BDI-II), anxiety by State-Trait Anxiety Inventory (STAI-Y), level of psychological distress by 12-item General Health Questionnaire (GHQ-12) and perceived social support by the Multidimensional Scale of Perceived Social Support (MSPSS). The general linear model analysis revealed a significant relationship between TAS-20 overall and TAS-20 sub-score for difficulty identifying feelings and VDT z-scores in the left index with no interaction by year of education and sensory NCS results. Our results demonstrated the association between impairment of vibratory sensation of the left hand, reflecting cutaneous mechanoceptor dysfunction, and alexithymia, particularly the difficulty to identify feelings. The importance of delivering to patients with neuropathic pain personalized care that takes into account not only the neurophysiological aspects but also the aspects of mental functioning is discussed.

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Bücher zum Thema "Mechanoception"

Griffiths, Hugh. Biologically-Inspired Radar and Sonar: Lessons from Nature. SciTech Publishing, Incorporated, 2017.

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Griffiths, Hugh. Biologically-Inspired Radar and Sonar: Lessons from Nature. SciTech Publishing, Incorporated, 2017.

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Griffiths, Hugh. Biologically-Inspired Radar and Sonar: Lessons from Nature. SciTech Publishing, Incorporated, 2017.

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