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1
Cano Pérez, María José. „Pilar Romeu Ferré, (2016) <em>El Meam Loez de Josué. Índices y paratextos.</em> Barcelona: Tirocinio, pp. 313, ISBN 978-84-942925-4-5.“ Miscelánea de Estudios Árabes y Hebraicos. Sección Hebreo 65 (28.12.2016): 205–6. http://dx.doi.org/10.30827/meahhebreo.v65i0.951.
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Laschewski, Gudrun, und Andreas Matzarakis. „Long-Term Changes of Positive Anomalies of Erythema-Effective UV Irradiance Associated with Low Ozone Events in Germany 1983–2019“. Environments 10, Nr. 2 (15.02.2023): 31. http://dx.doi.org/10.3390/environments10020031.
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In order to assess whether there is an increasing need for adaptation to the associated human health risks, the long-term occurrence (1983–2019) of low-ozone events (LOEs) with associated near-surface anomalies of erythema-effective UV irradiance was examined using an impact-related approach. Based on satellite data, means of four locations in Germany (Sylt, Berlin, Frankfurt, Munich) were compared for three subperiods (T1: 1983–1989, T2: 1990–1997, T3: 1998–2019). The period of peak global ozone depletion in the 1990s (T2) is characterized by a larger frequency of LOEs than the preceding (T1) and the subsequent (T3) subperiods. During the most recent subperiod (T3), the mean number of LOEs is 1.1 ± 0.5 events/year, with a variability of 0 to 4.2 ± 0.8 events/year, and shows a statistically significant decrease in the annual number of −4.8%/year. The annual totals of the LOE-associated anomalies of the erythema-effective UV radiation dose show no trend during T3. With regard to LOE-associated UV index anomalies, spring is the season most affected by LOEs, with more than half of all cumulative UV peak loads, while the absolute maximum values of the LOE-associated UV index anomaly of about 1.8 UV index occur near the summer solstice. Within the most recent subperiod (T3), summer contributes an increasing share of the peak loads. Overall, the study confirms that LOEs pose health risks due to intermittent, pronounced positive anomalies in erythema-effective UV irradiance and therefore require special attention and adaptation measures. Long-term changes can be identified, but to date there has been no evidence of an increasing health risk in Germany.
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Gajewska, Magdalena. „Microbial Quality of Traditional Meat Products Manufactured on a Small Scale by Polish Farms in the Lodz Region“. Journal of Emergency Medicine: Open Access 2, Nr. 1 (30.08.2024): 01–11. http://dx.doi.org/10.33140/jemoa.02.01.09.
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The aim of present study was to assess the microbiological quality of eight traditional meat products (black pudding, white brown, baked pate, roasted pork, raw smoked ham, smoked steamed sausage, raw smoked bacon, raw smoked loin) manufactured by polish farmers in the Lodz region. A total of 37 samples were collected and analyzed twice: within 24 h after purchase from manufactures and after 7 days of storage. Mesophiles, lactic acid bacteria (LAB), Enterobacteriaceae, presence of Listeria monocytogenes and Salmonella spp. were determined. The counts of isolated microorganisms varied depending on the product type and manufacturer. Mesophiles and lactic acid bacteria constituted the main microflora in the tested meat products. Enterobacteriace value was below detection limit in the most samples. The highest mean bacteria counts (mesophiles, LAB and Enterobacteriace) during storage were estimated in black pudding, followed by smoked steamed sausage and white brown. In opposite, the lowest mean bacteria levels were in baked pate and roasted pork. The obtained results showed significant influence of storage time on the mean number of mesophiles and LAB in the meat samples. Negative results for Salmonella spp. and Listeria monocytogenes were observed during 7 days of storage, indicating the safety of the studied meat products.
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BARTOSZEK, WOJCIECH, und NAZIFE ERKURŞUN. „On quasi-compact Markov nets“. Ergodic Theory and Dynamical Systems 31, Nr. 4 (20.07.2010): 1081–94. http://dx.doi.org/10.1017/s0143385710000350.
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AbstractWe extend a theorem of Lotz, which says that any Markov operator T acting on C(X) such that T* is mean ergodic and all invariant measures have non-meager supports must be quasi-compact, to Lotz–Räbiger nets.
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Scott, David R., David A. Lockner, James D. Byerlee und Charles G. Sammis. „Triaxial testing of Lopez Fault gouge at 150 MPa mean effective stress“. Pure and Applied Geophysics PAGEOPH 142, Nr. 3-4 (1994): 749–75. http://dx.doi.org/10.1007/bf00876063.
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Agarwalla, Avinesh, Kaisen Yao, Christon Darden, Anirudh K. Gowd, Seth L. Sherman, Jack Farr, Beth Ellen Shubin Stein, Nirav H. Amin und Joseph N. Liu. „Assessment and Trends of the Methodological Quality of the Top 50 Most Cited Articles on Patellar Instability“. Orthopaedic Journal of Sports Medicine 9, Nr. 1 (01.01.2021): 232596712097201. http://dx.doi.org/10.1177/2325967120972016.
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Background: Studies with a low level of evidence (LOE) have dominated the top cited research in many areas of orthopaedics. The wide range of treatment options for patellar instability necessitates an investigation to determine the types of studies that drive clinical practice. Purpose: To determine (1) the top 50 most cited articles on patellar instability and (2) the correlation between the number of citations and LOE or methodological quality. Study Design: Cross-sectional study. Methods: The Scopus and Web of Science databases were assessed to determine the top 50 most cited articles on patellar instability between 1985 and 2019. Bibliographic information, number of citations, and LOE were collected. Methodological quality was calculated using the Modified Coleman Methodology Score (MCMS) and the Methodological Index for Non-Randomized Studies (MINORS). Mean citations and mean citation density (citations per year) were correlated with LOE, MCMS, and MINORS scores. Results: Most studies were cadaveric (n = 10; 20.0%), published in the American Journal of Sports Medicine (n = 13; 26.0%), published between 2000 and 2009 (n = 41; 82.0%), and conducted in the United States (n = 17; 34.0%). The mean number of citations and the citation density were 158.61 ± 59.53 (range, 95.5-400.5) and 12.74 ± 5.12, respectively. The mean MCMS and MINORS scores were 59.62 ± 12.58 and 16.24 ± 3.72, respectively. No correlation was seen between mean number of citations or citation density versus LOE. A significant difference was found in the mean LOE of articles published between 1990 and 1999 (5.0 ± 0) versus those published between 2000 and 2009 (3.12 ± 1.38; P = .03) and between 2010 and 2019 (3.00 ± 1.10; P = .01). Conclusion: There was a shift in research from anatomy toward outcomes in patellar instability; however, these articles demonstrated low LOE and methodological quality. Higher quality studies are necessary to establish informed standards of management of patellar instability.
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Pakdeesan, Theerapong, und Supawadee Lapcharoen. „Critical Leadership of School Administrators Under the Office of Primary and Secondary Education Service Area in Loei Province“. Community and Social Development Journal 25, Nr. 2 (12.06.2024): 95–107. http://dx.doi.org/10.57260/csdj.2024.267297.
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The objective of this research is 1) to study the level of critical leadership of school administrators according to the opinions of teachers under the Office of Primary and Secondary Educational Service Area in Loei Province, and 2) to compare the level of critical leadership of school administrators according to the opinions of teachers under the Primary and Secondary Educational Service Area Office in Loei Province, classified by education, affiliation, and work experience. Which the population includes Teachers under the Primary and Secondary Educational Service Area Office in Loei Province for the academic year 2022 total 3,893 people, and the sample group used in this study was teachers in schools under the Primary and Secondary Educational Service Area Office in Loei Province in the academic year 2022, totaling 354 people. The instrument used in the study was a questionnaire regarding critical leadership characteristics of school administrators, consisting of 40 questions. There is a consistency between the questions and the objective is between 0.60-1.00 with the entire confidence value being 0.982. Statistics used in research namely mean, standard deviation, t-test, analysis of one-way variance, and pairwise mean differences were tested using Scheffe's method. Finding were as follows: 1) the Primary and Secondary Educational Service Area Office in Loei Province has a high degree of critical leadership in its overall management of school administrators, when considering each aspect, it was found that it was at a high level in every aspect, arranged from highest to lowest average as follows; cultural diversity, change, empowerment, and ethics, and 2) the findings of comparing teachers' perceptions of the critical leadership of school officials under the Primary and Secondary Educational Service Area Offices in Loei Province, classified by educational level, affiliation, and work experience, are similar in terms of the overall situation as well as income.
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Bugarin, Amador, Grant Schroeder, Brendan Y. Shi, Kristofer J. Jones und Thomas J. Kremen. „Assessment of Characteristics and Methodological Quality of the Top 50 Most Cited Articles on Platelet-Rich Plasma in Musculoskeletal Medicine“. Orthopaedic Journal of Sports Medicine 10, Nr. 5 (01.05.2022): 232596712210930. http://dx.doi.org/10.1177/23259671221093074.
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Background: The wide range of clinical applications and controversial scientific evidence associated with platelet-rich plasma (PRP) therapy in musculoskeletal medicine requires an examination of the most commonly cited studies within this field. Purpose: To identify the 50 most cited articles on PRP, assess their study design, and determine any correlations between the number of citations and level of evidence (LoE) or methodological quality. Study Design: Cross-sectional study. Methods: The Web of Science database was queried to identify the top 50 most cited articles on PRP in orthopaedic surgery. Bibliometric characteristics, number of citations, and LoE were recorded. Methodological quality was evaluated using the Modified Coleman Methodology Score (MCMS), Methodological Index for Non-randomized Studies (MINORS), and Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO). The Pearson correlation coefficient and Spearman correlation coefficient ( r S) were used to determine the degree of correlation between the number of citations or citation density and LoE, MCMS, MINORS score, and MIBO score. Student t tests were performed for 2-group comparisons. Results: The top 50 articles were published between 2005 and 2016 in 21 journals. The mean number of citations and citation density were 241 ± 94 (range, 151-625) and 23 ± 8, respectively, and the mean LoE was 2.44 ± 1.67, with 15 studies classified as LoE 1. The mean MCMS, MINORS score, and MIBO score were 66.9 ± 12.6, 16 ± 4.7, and 12.4 ± 3.7, respectively. No correlation was observed between the number of citations or citation density and LoE, MCMS, MINORS score, and MIBO score. A significant difference ( P = .02) was noted in LoE in articles from the United States (3.56 ± 1.7) versus outside the United States (2 ± 1.5). Seven of the 8 in vivo studies were published between 2005 and 2010, whereas 19 of the 25 clinical outcome investigations were published between 2011 and 2016. Studies that were published more recently were found to significantly correlate with number of citations ( r S = –0.38; P = .01), citation density ( r S = 0.36; P = .01), and higher LoE ( r S = 0.47; P = .01). Conclusion: The top 50 most cited articles on PRP consisted of high LoE and fair methodological quality. There was a temporal shift in research from in vivo animal studies toward investigations focused on clinical outcomes.
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Daulay, Adinda Tasya Aulia Octaviani Prayudi, und Khoirul Anwar. „E-LEARNING IMPLEMENTATION IN RURAL AREA: THAILAND PRIMARY SCHOOL EFL PERCEPTION“. JEELL (Journal of English Education, Linguistics and Literature) English Department of STKIP PGRI Jombang 8, Nr. 2 (02.02.2022): 37. http://dx.doi.org/10.32682/jeell.v8i2.2207.
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This study aimed to find primary school EFL perception in Loei on E-learning during the Covid-19 outbreak. This study is using descriptive quantitative design using questionnaire as the instrument and involving 125 primary school EFL from 6 different districts in Loei, Thailand. To find valid answer, Gutmann scale has been applied in this study consisting of 4 aspects namely interactivity, independency, accessibility and enrichment. The results show that the mean score is 8.34 (min score: 3 & max score: 12) and the standard deviation is 2.152. Thus, it can be said that EFL perceptions in Loei, Thailand primary school on E-learning implementation is fairly good. The findings of this study are to assist English teachers making it possible to design more effective E-learning implementation during the outbreak mainly for EFL in rural areas.
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Loeb, Josh. „‘Popcorning’: an expression of joy, the ‘zoomies’ or something more sinister?“ Veterinary Record 195, Nr. 7 (04.10.2024): 276–77. http://dx.doi.org/10.1002/vetr.4758.
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López-Beyliss, Mariana, Jade Jozabel Ponce-Galván, Luis Alberto Ruvalcaba-Lugo, Rosa Hidemi Ortega-Armenta, Francina B. López-Tarín und Paúl Fernando Cuevas-González. „Development of a biscuit-type baked meat product based on chicken giblets“. Nacameh 15, Nr. 01 (30.06.2021): 1–15. http://dx.doi.org/10.24275/uam/izt/dcbs/nacameh/2021v15n1/lopez.
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Vidayanti, Istiana Nur, Peerapol Sukon, Seri Khaengair, Chaiwat Pulsrikarn und Sunpetch Angkittitrakul. „Prevalence and antimicrobial resistance of Salmonella spp. isolated from chicken meat in upper northeastern Thailand“. Veterinary Integrative Sciences 19, Nr. 2 (28.12.2020): 121–31. http://dx.doi.org/10.12982/vis.2021.011.
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Foodborne disease associated with Salmonella spp. occurs in some parts of the world, including Thailand. The present study aimed to determine prevalence, antimicrobial resistance, and serotypes of Salmonella spp. isolated from chicken meat in upper northeastern Thailand. A total of 326 swab samples of fresh chicken meat were collected from wet markets in Khon Kaen, U-don Thani, Nong Khai, Loei, Kalasin, Maha Sarakham, and Bueng Kan Provinces, northeastern Thailand, between August and November 2019. All samples were analyzed for Salmonella spp. using the ISO 6579:2002/AMD 1:2007 method. The isolates were tested for antimicrobial susceptibility using the Kirby-Bauer method, and the serotypes of isolates positive were identified. The overall prevalence of Salmonella spp. isolated from chicken meat was 36.2% (118/326), and prevalence in the provinces was as follows: U-don Thani, 70.9%; Bueng Kan, 66.67%; Khon Kaen, 45.9%; Kalasin, 31.25%; Nong Khai, 29.8%; Maha Sarakham, 26.42% and Loei, 12.5%. Resistance was highest for nalidixic acid at 31%, followed by ampicillin (24%), tetracycline (19%), sulfamethoxazole trimethoprim (8%), norfloxacin (5%), ciprofloxacin (4%), amoxicillin (4%), and chloramphenicol (1%). However, all isolates were susceptible to ceftazidime. Twenty-seven serotypes were detected, with the Corvallis, Singapore, Kentucky and Agona serotypes being the most common. Salmonella spp. were detected in a large percentage of the swab samples of chicken meat in every city, indicating a high level of contamination of chicken meat. Given the high resistance of Salmonella strains to some antibiotics, it may be beneficial to find other drugs for salmonellosis treatment and to use antibiotics more wisely.
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Mirghelenj, S. A., A. Golian und V. Taghizadeh. „Enrichment with long chain omega-3 fatty acids and sensory evaluation of chicken meat“. Proceedings of the British Society of Animal Science 2009 (April 2009): 230. http://dx.doi.org/10.1017/s1752756200030696.
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N-3 fatty acids are essential for normal growth and development, and may play an important role in prevention of coronary artery disease, hypertension, diabetes, arthritis, other inflammatory and autoimmune disorders and cancer in humans (Simopoulos, 1999). Fatty acid profiles of broiler meat may be modified by adding fish oils to the diet (Lopez-Ferrer et al., 2001). When meat is enriched with PUFA, particularly n-3 long-chain fatty acids (C≥20), all sources of added vegetable oils seem to be less effective than marine oils (Bou. R et al., 2004). The purpose of this experiment was to study the effect of dietary fish oil on fatty acid composition of thigh and breast meat in broiler chickens.
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Buford, MD, Don, Sharmila Tulpule, Jasmine Hyder und Henry Boot. „Average Level Of Evidence Of Papers Published In Six Orthopedic Journals“. Biologic Orthopedics Journal 2, Nr. 1 (09.12.2020): e48-e50. http://dx.doi.org/10.22374/boj.v2i1.9.
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Background
An assessment of the average level of evidence (LOE) of clinical research papers in peer reviewed orthopedic surgery journals has not previously been published. In this paper we report on the average LOE of papers published in six of the top English language orthopedic surgery journals.
Methods
Six well established orthopedic journals were identified by using the Google Scholar H5 Journal Index. We selected 6 of the top ten journals identified by the Index. The six journals that were evaluated for this project were as follows: The American Journal Of Sports Medicine (AJSM); Clinical Orthopedics and Related Research (CORR); Journal of Bone and Joint Surgery (JBJS); Knee Surgery, Sports, Traumatology, Arthroscopy (KSSTA); Journal of Arthroscopy (Arthros.); and the Journal of Shoulder and Elbow Surgery (JSES). Thirteen consecutive monthly issues (July, 2018 - July, 2019) of each journal were evaluated for the LOE of each clinical paper. The assigned LOE was used if published, or the level of evidence was assigned by the senior author (DAB) if one was not listed. For each journal, the overall mean LOE along with the variance and standard deviation was calculated with all confidence intervals set at 95%. Summary data was statistically analyzed to provide an overall mean LOE for the 6 journals evaluated.
Results
For AJSM, we evaluated 246 clinical research articles that had an average LOE of 2.96 +/- 0.16. For CORR, we evaluated 155 papers that had an average LOE of 2.83 +/- 0.19. For JBJS, we evaluated 164 papers that had an average LOE of 3.04 +/- 0.13. For KSSTA, we evaluated 402 papers that had an average LOE of 3.05 +/- 0.16. For Arthros. we evaluated 226 papers that had an average LOE of 3.19 +/- 0.10. For JSES, we evaluated 237 papers that had an average LOE of 3.25 +/- 0.13.
In summary, for the 1425 clinical research papers published in 98 issues of 6 of the top orthopedic journals, we found the average Level Of Evidence to be 3.05 +/- 0.16.
Conclusions
The goal of scientific study design is to prove or disprove a hypothesis while minimizing bias and errors. The gold standard for therapeutic studies has been a double blind, randomized controlled trial (RCT). However, it is not possible or feasible for every clinical study to have a blinded RCT design. Additionally, clinically relevant and actionable data can come from studies that are not RCTs. In a medical discipline like orthopedics many interventions are invasive, making controlled trials or blinded trials unethical or technically not practical. Our analysis of over 1400 peer reviewed publications in one year in 6 of the top English language orthopedic journals reveals that the average level of evidence deemed worthy of publication is level 3. In terms of the most common study design, the average published clinical study in these orthopedic journals was a case-control study.
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Sgadari, Arianna, Antonio Izzo, Francesco Smeraglia, Antonio Coviello, Shelain Patel, Massimo Mariconda und Alessio Bernasconi. „Analysis of the 50 Most Cited Articles on Achilles Tendon Injury“. Orthopaedic Journal of Sports Medicine 11, Nr. 5 (01.05.2023): 232596712311708. http://dx.doi.org/10.1177/23259671231170846.
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Background: Achilles tendon injuries represent one of the most common reasons for referral to orthopaedic surgeons. Purpose: To outline the characteristics, examine trends in publication, and evaluate the correlation between citations and study quality of the 50 most cited articles on Achilles tendon injury. Study Design: Cross-sectional study. Methods: After searching the Web of Science for articles published in orthopaedic journals, we identified the 50 most cited articles on Achilles tendon injury and abstracted their characteristics. Risk of bias was assessed using the modified Coleman Methodology Score (mCMS). Multiple bivariate analyses (Pearson or Spearman correlation coefficient) were used to evaluate the association among number of citations, citation rate (citations/year), 2020 journal impact factor (JIF), year of publication, level of evidence (LoE), study type (tendon rupture or chronic tendinopathy), sample size, and mCMS. Results: The top 50 articles were cited 12,194 times. Each article had a mean ± SD 244 ± 88.8 citations (range, 157-657) and a citation rate of 12.6 ± 5.4 per year (range, 3-28). A total of 35 studies (70%) were published between 2000 and 2010. The citation rate of the 16 most recent studies was almost double that of the 16 oldest studies (17.5 vs 9.9; P < .001). Nineteen studies (49%) were classified as having poor quality (mCMS <50 points). The mean JIF of the 9 journals that published the studies was 5.1. The citation rate correlated with the number of citations ( r = 0.56; P < .001), publication year ( r = 0.60; P < .001), and LoE ( r = –0.44; P = .005). The publication year correlated with the LoE ( r = –0.40; P = .01). Study quality in terms of mCMS correlated with the JIF ( r = 0.35; P = .03) and LoE ( r = –0.48; P = .003) but not the citation rate ( P = .15). Conclusion: The mean LoE and the citation rate of the most cited articles on Achilles tendon injury both significantly increased over time. Although the JIF was positively correlated with study quality, almost half of the studies had poor-quality methodology.
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Catto, Stephen. „DOES πρoσευχας πoιεισαι, IN JOSEPHUS' ANTIQUITIES OF THE JEWS 14.257-58, MEAN 'BUILD PLACES OF PRAYER'?“ Journal for the Study of Judaism 35, Nr. 2 (2004): 159–68. http://dx.doi.org/10.1163/157006304773787456.
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AbstractIn Antiquities of the Jews 14.257-58, Josephus records a decree by the people of Halicarnassus in which the Jews are, according to the Loeb translation by Marcus, allowed to "build places of prayer." However, this could also be translated as "offer prayers." In this article I first assess the arguments made by scholars who propose translating it in either of these ways, arguing that the solutions offered are inadequate. I then discuss Josephus' use of πoιεω in the middle voice pointing out that he never uses it to describe the construction of a whole building, only parts of a building. A comparison with the use of πoιεω in the New Testament, Philo and other sources confirms that in this decree "offer prayers" is the translation that should be adopted.
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Pinto, Roberto Magalhães, Rodrigo Caldas Menezes und Delir Corrêa Gomes. „First report of five nematode species in Phasianus colchicus Linnaeus (Aves, Galliformes, Phasianidae) in Brazil“. Revista Brasileira de Zoologia 21, Nr. 4 (Dezember 2004): 961–70. http://dx.doi.org/10.1590/s0101-81752004000400034.
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This paper deals with the first report of the nematodes Dispharynx nasuta (Rudolphi, 1819) Stiles & Hassall, 1920, Gongylonema ingluvicola Ransom, 1904, Oxyspirura mansoni (Cobbold, 1879) Ransom, 1904, Subulura brumpti (Lopez-Neyra, 1922) Cram, 1923 and Tetrameres fissipina (Diesing, 1860) Travassos, 1914, parasitizing the ring-necked pheasant, Phasianus colchicus Linnaeus, 1758 in Brazil. Morphological data on the parasites as well as on the prevalence, mean intensity, mean abundance and range of intensity of the nematodes in the infected birds are provided.
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Reyes, Anny, Emily L. Johnson und Carrie R. McDonald. „5 Examining the Cognitive, Vascular, and Lifestyle Profiles of Older Adults with Late-Onset Epilepsy“. Journal of the International Neuropsychological Society 29, s1 (November 2023): 793–94. http://dx.doi.org/10.1017/s1355617723009852.
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Objective:Older adults represent the fastest-growing population of individuals with epilepsy with an incidence that peaks after age 65. Patients with late-onset epilepsy (LOE) have a multitude of risk factors for accelerated cognitive and brain aging, including vascular and metabolic risk factors. Despite this, there are few studies investigating the cognitive profiles of older adults with LOE, a neglected area in aging research. We examine the cognitive profiles of older adults with LOE and determine the contribution of demographic and vascular risk factors to impairment.Participants and Methods:Participants were part of the Atherosclerosis Risk in Communities Study (ARIC) and the incidence of epilepsy was identified using ARIC hospitalization records and Centers for Medicare and Medicaid Services claims data from 1991 to 2015. Approximately 1.8% of the participants with sufficient Medicare coverage data were classified as having LOE (LOE n=281; Non-LOE n=9808). Vascular, lifestyle, and cognitive data were obtained from the ARIC Neurocognitive Study (ARIC-NCS) which consisted of three visits since 2011. Participants with ARIC-NCS visits completed after the onset of seizures were included in the final sample. Non-LOE participants with normal cognition (Black: n=603 and White: n=2543 participants independently) were used to generate z-scores across tests of language, memory, executive function, and processing speed/attention. Impairment was defined as <1.5 standard deviations below the mean of the normative sample. Stepwise regressions were conducted to examine the contribution of demographic (age, race, sex, education) and vascular risk factors (hypertension, diabetes, hyperlipidemia, obesity, smoking) to cognitive performance.Results:Average age of first seizure of all LOE participants (n=281) was 76.23 (SD=6.24), 55.9% female, 30.7% Black/African American, and the majority had either a college (28.1%) or high school degree (26%). Fifty-six LOE participants had ARIC-NCS visits after the onset of seizures (average age=79.84, SD=5.17, 57.1% female, 32.1% Black). Approximately 67.9% of the sample had at least one vascular risk factor with 81.5% having hypertension, 37% diabetes, 26.4% hyperlipidemia, 20.4% obesity (BMI>30), and 4.5% current smoker. The most frequently impaired domains were language (naming=29.7%; animal fluency=20%; letter fluency=30%) and memory (prose immediate recall=18.4%; prose delayed recall=44.7%; word delayed recall=19.4%). Higher education was associated with better naming (b=0.801, p=0.040). Female sex (b=-0.799, p=0.017) and lower education levels (b=0.418, p=0.050) were associated with poorer immediate prose recall. Older age was associated with poorer delayed prose recall (b=-0.191, p=0.036). Hypertension was associated with worse digit span backward (b=-0.942, p=0.002).Conclusions:In older adults with LOE, language and memory were the most commonly impaired cognitive domains, similar to studies in early onset epilepsy. Vascular risk factors were prevalent among LOE and hypertension was associated with worse working memory. Further, important demographic factors (sex, education, and age) were associated with the extent of cognitive impairment. Characterizing cognitive profiles in LOE and determining the contribution of demographic and vascular factors to impairment could help to identify patients at risk for future cognitive decline and/or the development of LOE itself, as well as interventions aimed at reducing the risk of further decline.
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Srivatsav, V., B. Zhang, I. Nadeem, S. Upadhye und Michael G. Degroote. „P144: Assessment of the quality of evidence presented at the Canadian Association of Emergency Physicians annual meeting over a five-year period (2013-2017)“. CJEM 20, S1 (Mai 2018): S108. http://dx.doi.org/10.1017/cem.2018.342.
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Introduction: The CAEP annual meeting presents the latest evidence for clinical practice, but there has not yet been an appraisal of the abstracts presented at this conference. Therefore, we sought to evaluate the level of evidence of research presented at the annual meeting, and assess for trends over a five-year period (2013-2017). Methods: We conducted a scoping review that included all CAEP abstracts from 2013-2017, obtained through the Canadian Journal of Emergency Medicine. Two reviewers assessed eligibility and extracted data from abstracts individually, with conflicts resolved by a third reviewer. Qualitative research was excluded. Extracted data included type of presentation (ex. oral, poster), sample size, study design and type of study (therapeutic, prognostic, diagnostic, education, quality improvement, or systems-wide/economic analyses research). A level of evidence (LOE) was assigned using the 2011 Oxford Centre for Evidence-Based Medicine criteria. Results: Abstracts from 2014-2017 have been analyzed thus far, 1090 of which were eligible and 990 included. Inter-rater agreement for screening and data extraction was high ( value 0.87 and 0.84 respectively). Systems-wide/economic analyses research was the predominant type of study (28.6%, 283/990), followed by therapeutic (19.9%, 197/990) and education (19.9%, 195/990). The mean LOE was 2.81 (95% CI 2.77,2.85). The highest proportion of studies were of level III evidence (77.7%, 769/990), followed by level II (9.6%, 95/990) and level I evidence (7.8%, 77/990). 72.1% (124/172) of all level I and II abstracts were presented in 2016 and 2017. A significant change in LOE between years was evident (p<0.0001, chi-squared). The greatest proportion of level I and II abstracts were lightning oral (41.9%, 72/172), followed by posters (36.0%, 62/172). The best average LOE was observed for lightning oral (2.64, 95% CI 2.56, 2.72), with the poorest average LOE witnessed for moderated posters (2.90, 95% CI 2.83, 2.97). A significant difference was present in mean LOE between types of presentations (p<0.0001, one-sided ANOVA). Conclusion: The majority of abstracts were level III evidence. The lightning oral sessions had the greatest proportion of level I and II evidence presented. Recent years of the conference have also seen the presentation of a greater number of level I and II evidence, which may suggest a shift towards generating and disseminating higher level evidence in emergency medicine.
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Giri, Dhirendra Kumar, Rajkumar Jha und Tarakant Bhagat. „Oral Hygiene and Periodontal Status of Visually Impaired Individuals of a Residential School in Eastern Nepal“. Journal of Nepalese Society of Periodontology and Oral Implantology 3, Nr. 2 (31.12.2019): 51–53. http://dx.doi.org/10.3126/jnspoi.v3i2.30882.
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Introduction: Gingival and periodontal diseases are a matter of serious concern in Nepalese population. These diseases may also be present in visually impaired individuals. So, the scientific fact is necessary to unmask this and the pathogenesis behind it.
Objective: To assess the oral hygiene and periodontal status of visually impaired individuals of a residential school in Eastern Nepal.
Methods: A study was conducted at Gyanchakchu Vidyalaya in Dharan-15. A total of 130 visually impaired individuals (88 males and 42 females) with the mean age of 6-20 years were included in the study. Information regarding oral hygiene practices was gathered through personal interaction by the interviewers. Oral hygiene status was assessed by using Plaque Index of Silness and Loe (1964) and Gingival Index of Loe and Silness (1963) and to assess the periodontal status, Community Periodontal Index was used.
Results: A total of 112 (86.2%) participants, brushed their teeth with the help of toothbrush and toothpaste, 101 (77.7%) of them brushed once a day in morning, 83 (63.8%) of the students used horizontal brushing technique and 90 (69.2%) of the students rinsed their mouth after meal. Periodontal and gingival status of visually impaired individual show that majority 90 (69.2%) had no periodontal pocket and 83 (63.8%) had slight loss of attachment.
Conclusion: The oral hygiene status and periodontal status of visually impaired individuals can be improved more through an in-service educational programmes
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Judy, Ryan P., Spencer Talentino, Asheesh Bedi und Bryson P. Lesniak. „Ten Years of Sports Health: Authorship Characteristics and Levels of Evidence“. Sports Health: A Multidisciplinary Approach 12, Nr. 6 (06.07.2020): 573–78. http://dx.doi.org/10.1177/1941738120922163.
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Context: Sports Health: A Multidisciplinary Approach, now 10 years into production, has been ranked a top-25 journal in sport sciences and has tripled its impact throughout its existence. Objective: To evaluate authorship trends and levels of evidence (LOE) of articles published in Sports Health from 2009 to 2018. The secondary aim was to analyze funding sources and internationalization throughout the journal’s tenure. Data Sources: All clinical studies published in Sports Health between the years 2009 and 2018 were examined. Study Selection: All publications from the provided years were electronically reviewed by 2 reviewers and evaluated for inclusion criteria. Editorials, society news, memorials, letters to the editor, and corrigenda were excluded. Study Design: Systematic review. Level of Evidence: Level 5. Data Extraction: Articles were examined for number of authors, presence of female authorship, funding, country of origin, international collaboration, academic degree or certification of first and senior authors, and LOE. Clinical articles were assigned LOE based on guidelines from the University of Oxford’s Centre for Evidence-Based Medicine. Results: A total of 654 articles were examined. The percentage of high-LOE studies increased throughout the study period. The percentage of publications with female authors also increased throughout the study period. The mean number of authors per article increased from 3.2 to 4.6 over the 10-year period ( P < 0.05). The percentage of publications with international collaboration stayed consistent, while the number of countries per year increased during the study period. Overall, institutions from 23 countries have published in Sports Health since its inception to the time of this study. Conclusion: Female authorship in Sports Health surpasses industry standards, and the percentage of high-LOE studies remains remarkably high. Sports Health has stayed true to its multidisciplinary scope, as evidenced by the authors’ varying degrees and numerous countries that publish in the journal.
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Jabłonowska, Elżbieta, und Ewa Małolepsza. „Causes of death in HIV-infected patients in the region of Lodz, Poland from 1995 through 2005“. Open Medicine 4, Nr. 2 (01.06.2009): 179–83. http://dx.doi.org/10.2478/s11536-009-0005-x.
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AbstractIn 2005, 440 patients infected with HIV were registered in the AIDS center in Lodz, Poland. The aim of our study was to analyze the causes of death in 70 fatal cases. We analyzed the data from 70 fatal cases from 1995 through 2005. Of the fatal cases we investigated, 10 were in women and 60 in men. The most common route of HIV transmission was intravenous drug use (50%). At the time of death, the mean age of patients was 36,48 years, and the mean CD4 count was 115,14 cells per microliter. The mean time from HIV diagnosis to death was 3,75 years. The leading cause of death in the group from 1995 through 2004 was AIDS. In 2002, liver diseases resulting from hepatitis C virus (HCV) infection were the cause of death in two patients. In 2005, two patients died as a result of myocardial infarction. The prevalence of fatal cases decreased from 9,09 % in 1995 to 1,59 % in 2005. Hepatitis B surface antigen (HBsAg) was found in 4 of 62 patients (6,45%), anti-HCV in 28 patients (45,16%), and both hepatitis B virus (HBV) and HCV infection in 5 patients (8,07%). Coinfections occurred most frequently in intravenous drug users (IDUs). In conclusions: (1) AIDS is still the leading cause of death in HIV-positive patients in the Lodz region; (2) the emerging cause of death in HIV-positive patients is liver disease as the sequel of HBV and HCV coinfections; (3) heart disease is becoming an important cause of death in HIV-positive patients.
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Bernasconi, Alessio, Arianna Sgadari, Antonio Izzo, Domenico Marasco, Francois Lintz, Cesar de Cesar Netto, Massimo Mariconda und Francesco Smeraglia. „A Citation Analysis Study of the 50 Most-Cited Articles on the Achilles Tendon“. Foot & Ankle Orthopaedics 7, Nr. 4 (Oktober 2022): 2473011421S0058. http://dx.doi.org/10.1177/2473011421s00582.
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Category: Other; Basic Sciences/Biologics Introduction/Purpose: Achilles tendon injuries represent one of the most common reasons of referral to orthopaedic surgeons. The purpose of this study was to determine the 50 most-cited articles on Achilles tendon pathologies in order to outline their characteristics, examine trends in publication and evaluate the correlation between citations and the quality of evidence. Methods: We searched Web of Science papers with the single keyword 'Achill*'. We identified and analyzed the top 50 most- cited articles and abstracted their characteristics. The methodological quality was assessed using the modified Coleman Methodology Score (mCMS). The correlation between the number of citations, the citation rate (citations/y), the impact factor of the journal for the year 2020 (JIF), the year of publication, the Level of Evidence (LoE), the type of study (tendon rupture, acute tendinopathy, chronic tendinopathy), the sample size and the mCMS was assessed through multiple bivariate analyses (Pearson or Spearman correlation coefficient). Results: Mean number of citations (+-SD) was 244 +- 88.8 (range, 657 to 157), with a total number of citations of 12.194 and a mean citation rate of 12.6 +- 5.4 (range, 28 to 3). The mean impact factor for the ten journals in which the 50 manuscripts were published was 5.1. The citation rate correlated with the number of citations (R=0.56, p<0.001), the year of publication (R=0.60, p<0.001) and the LoE (R=-0.37, p=0.022), but not with the citation rate (p=0.15). The year of publication correlated with the LoE as well (R=-0.43, p=0.008). Also, the quality of studies (in terms of mCMS) correlated with the impact factor of journals (R=0.35, p 0.03) and with the LoE (R=-0.48, p=0.003). Only 20 out of 39 primary studies (51%) had a prospective and comparative design, while 19 studies (48%) were classified as of poor quality (< 50 points using the mCMS). Conclusion: Most-cited articles in the field of Achilles tendon injuries have generally been published on high-impact journals. Although the impact factor positively correlates with the quality of studies, their methodology is poor in almost half of cases. The average Level of Evidence provided by studies and their citation rate are both significantly increasing over time. Citation-based indicators do not represent robust measures of quality in studies dealing with Achilles tendon pathologies.
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Pierpont, Elizabeth, Julie Eisengart, Richard Ziegler, Gerald Raymond, Paul J. Orchard, Troy Lund und Weston P. Miller. „Neurocognitive Trajectory of Patients with Childhood Cerebral Adrenoleukodystrophy Who Received Allogeneic Hematopoietic Cell Transplantation at an Early Stage of Cerebral Disease“. Blood 128, Nr. 22 (02.12.2016): 4682. http://dx.doi.org/10.1182/blood.v128.22.4682.4682.
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Abstract Adrenoleukodystrophy (ALD) is an X-linked disorder of very long chain fatty acid metabolism which may manifest with adrenal gland and/or central nervous system disease. Thirty-five percent of affected boys develop cerebral involvement (cALD) during childhood. Characterized by progressive cerebral demyelination and resulting in devastating neurological and cognitive decline, cALD is usually fatal within years of clinically-evident disease. The only treatment known to enhance long-term survival and stabilize cerebral disease for boys with cALD is hematopoietic cell transplantation (HCT). It is well-established that the risk for negative long-term outcomes is significantly lower when HCT occurs at an earlier stage of cerebral white matter disease (ALD MRI severity score [Loes score] < 10). Nevertheless, there is limited knowledge of broad-based neurocognitive outcomes of patients transplanted with early-disease cALD. We studied all patients who underwent HCT for cALD at the University of Minnesota between January 1, 1991 and October 20, 2014. HCT preparative regimens varied with time, although most patients underwent myeloablative conditioning. Transplant allograft sources varied. Neurocognitive data were available for 63 patients who had a pre-transplant Loes MRI severity score < 10. Within this cohort, patients with less extensive cerebral disease (Loes ≤ 4) at the time of HCT had significantly higher scores on baseline tests of intellectual functioning than those with more cerebral involvement (Loes >4). This difference was particularly apparent on measures of nonverbal (visual) reasoning and processing speed. Furthermore, patients with more MRI-evident white matter disease at HCT showed more dramatic declines in neurocognitive test performance over time. In a subset of 20 patients who were followed for at least 4 years post-transplant, 15 patients (75%) demonstrated significant neurocognitive deficits (>1.5 SD below the mean) in at least one of the following domains: overall intellectual functioning (30%), attention (39%), verbal memory (33%), visual-motor integration (40%) and fine motor skills (58%). Results of this study provide evidence that within this patient group (boys undergoing HCT for cALD with Loes score < 10), patients have better neurocognitive outcomes when minimal cerebral disease is evident on neuroimaging prior to transplant. These data represent the largest analysis of cognitive outcomes in patients with early-disease cALD who underwent HCT. Our findings provide a benchmark for comparison to alternative or additional interventions for patients with cALD. Opportunities to enhance standard methods of detecting early cerebral disease and to intervene at the earliest possible stage of cALD should be explored. The emergence of newborn screening for adrenoleukodystrophy will provide avenues for improved pre-transplant monitoring and timing of intervention to preserve cognitive functioning and quality of life among patients with cALD. Disclosures No relevant conflicts of interest to declare.
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Hankins, David A., Ian E. Fletcher, Fermin Prieto, Andrew C. Ockuly, Orrin B. Myers, Gehron P. Treme, Andrew J. Veitch, Daniel C. Wascher, Robert C. Schenck und Dustin L. Richter. „Critical Evaluation of the Methodologic Quality of the Top 50 Cited Articles Relating to Knee Dislocation and Multiligamentous Knee Injury“. Orthopaedic Journal of Sports Medicine 7, Nr. 11 (01.11.2019): 232596711988050. http://dx.doi.org/10.1177/2325967119880505.
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Background: Many studies have evaluated the management of knee dislocations (KDs) and multiligamentous knee injuries (MLKIs). However, no study to date has analyzed the quality of the most cited articles in this literature. Hypothesis: There is a positive correlation between the number of article citations in the KD and MLKI literature and their methodologic quality. Study Design: Systematic review. Methods: The Web of Science online database was searched to identify the top 50 cited articles in KD and MLKI care. Demographic data were recorded for each study. The Modified Coleman Methodology Score (MCMS) and the Methodological Index for Non-randomized Studies (MINORS) were used to analyze the methodological quality of each article. Spearman correlation coefficients ( r s) were then calculated. Results: The articles identified were published between 1958 and 2015 in a wide variety of peer-reviewed journals (n = 16). The majority of study level of evidence (LOE) was of low quality (level 5, 16%; level 4, 54%; level 3, 16%; level 2, 14%). There were no studies of level 1 evidence. The mean MCMS and MINORS scores were 29.0 (SD, 19.1; range, 3-72) and 6.1 (SD, 3.7; range, 0-14), respectively. No significant correlation was identified between the number of citations and the publication year, LOE, MCMS, or MINORS ( r s = 0.123 [ P = .396]; r s = 0.125 [ P = .389]; r s = 0.182 [ P = .204]; and r s = 0.175 [ P = .224], respectively). Positive correlations were observed between improved MCMS and MINORS scores and more recent year of publication ( r s = 0.43 [ P = .002]; r s = 0.32 [ P = .022]) as well as improved study LOE ( r s = 0.65 [ P < .001]; r s = 0.67 [ P < .001]). Conclusion: The top 50 cited articles on KD and MLKI care consisted of low LOE and methodological quality, with no existing level 1 articles. There was no significant correlation between the number of citations and publication year, LOE, or study methodological quality. Positive correlations were observed between later publication date and improved methodological quality.
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Oriarte, Ronald, Eric Molines, Irene V. Taracina, Daisy A. Zamora A. Zamora, Jenette Pańoso, Merry Rose M. Olea und Wendell Leo T. Olea. „INSTRUCTIONAL COMPETENCIES OF MATHEMATICS TEACHERS AND THEIR PERFORMANCE IN THE EXECUTION OF TASK“. International Journal of Business, Law, and Education 4, Nr. 1 (01.02.2023): 15–24. http://dx.doi.org/10.56442/ijble.v4i1.102.
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This study determined the instructional competencies of Mathematics teachers and their performance in the execution of tasks in Lopez East District. The study used the descriptive-evaluated-correlational method of research with documentary analysis in describing the effects of instructional competencies and performance of the teachers. Purposive sampling was used as the locale of the study. The statistical tools used were weighted mean, frequency count, percentage, rank order, Kendall Coefficient of Concordance, and its corresponding Chi-square test. The instructional competencies of the teachers were Very Much Evident. There is a significant agreement on the rank orders on the instructional competencies in terms of knowledge of subject matter, communication skills, instructional practices, evaluation, and professionalism and there is no significant agreement in terms of problem solving. The teachers’ performance in the execution of tasks was Outstanding. There is a significant agreement on the rank orders of the level of teacher’s performance. The result of this study was a great help to the learners and also to the teachers, as facilitators of learning, are encouraged to employ modern methodologies such as using computer-based resources in teaching. The researcher was motivated to assess the instructional competencies of Mathematics teachers and their teaching performance in Lopez East District.
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Barkdoll, Brian D. „Discussion of “Mean Flow and Turbulence Structure of Open-Channel Flow Through Nonemergent Vegetation” by Fabián Lopez and Marcelo H. Garcia“. Journal of Hydraulic Engineering 128, Nr. 11 (November 2002): 1032. http://dx.doi.org/10.1061/(asce)0733-9429(2002)128:11(1032).
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Kanakamedala, Ajay C., Nathaniel P. Mercer, Alan Samsonov, Raymond J. Walls, Eoghan T. Hurley und John G. Kennedy. „Return to Sports and Clinical Outcomes in Suture-Tape Augmentation for Ankle Instability: A Systematic Review“. Foot & Ankle Orthopaedics 7, Nr. 1 (Januar 2022): 2473011421S0027. http://dx.doi.org/10.1177/2473011421s00271.
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Category: Ankle; Sports Introduction/Purpose: There is minimal literature on the use of suture-tape augmentation in the treatment of chronic lateral ankle instability (CLAI), prompting an investigation on its use and effect during surgery of the lateral ankle. The purpose of this systematic review is to evaluate the evidence for the use of suture-tape augmentation in the treatment of CLAI, and the outcomes following this technique. Methods: A literature search was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were included if they evaluated the use of suture-tape for CLAI. Quantitative and qualitative analysis was performed. Results: There were 11 studies (LOE II: 2, LOE III: 1, LOE IV: 8) with 334 patients and 334 ankles, and 66.7% were females. The mean age of patients was 27.3 years. The mean follow-up was 27.6 months (range: 11.5-38.5). Overall, 9 recurrent instability events (4.1%) were reported for suture-tape augmentation, with no significant difference between Modified Broström repair and suture-tape augmentation (MD;.81, 95% CI,.19, 3.50, I2 = 0%, p = 0.78). There was no significant difference in talar tilt angle (TTA) improvement between Modified Broström repair and suture-tape augmentation (MD; -0.07, 95% CI, -0.68, 60.54, I2 = 0%, p = 0.82). There was no significant difference in anterior talar translation (ATT) improvement between Modified Broström repair and suture-tape augmentation (MD; -0.06, 95% CI, -0.69, 0.56, I2 = 0%, p = 0.84). Conclusion: Suture-tape augmentation did not significantly improve clinical or radiological outcomes in the setting of Modified Broström repair for CLAI. Quicker return to play was the single most important advantage of the suture-tape augmentation procedure identified in the current study. This indicates that there is a role for suture-tape augmentation in ATFL repair for athletes and high-demand patients.
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Theroux, Mary C., und David West. „Letter to the Editor“. Pediatrics 93, Nr. 5 (01.05.1994): 871. http://dx.doi.org/10.1542/peds.93.5.871.
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We thank Drs Lopez and Urbansky for their comments. Their observation that the placebo group may have sufficiently biased the combined placebo/control group to account for the significant findings noted is reasonable, despite no significant differences being found between the placebo group and the control group. Analysis of variance among the three groups was carried out for the objective outcome variables. Differences in mean heart rate changes and maximum heart rate changes remained significant, and differences between study versus control groups and study versus placebo groups were both found to be significant, accounting for multiple comparisons.
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Mesgaran, M. Danesh, T. Tashakkori, A. Heravi Moussavi, S. Danesh Mesgaran, A. Vakili und A. A. Aslaminejad. „Evaluation of mathematical models to describe protein fraction degradation kinetics of various oilseed meals“. Proceedings of the British Society of Animal Science 2009 (April 2009): 171. http://dx.doi.org/10.1017/s1752756200030106.
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In situ procedure is a direct method of measuring the rumen degradation kinetic of a feed nutrient. Data obtained by this technique are generally analysed using an exponential curve (Ørskov and McDonald, 1979). However, very low attention has been paid to choice of mathematical model to fit the curves and goodness-of-fit of the model. Lopez et al. (1999) pointed out that the disappearance of some feed components, particularly structural carbohydrates, exhibits a larger variety of forms than for crude protein (CP). In the present study, two different mathematical models of a straight line or a negative exponential (France et al., 1990; and Ørskov and McDonald, 1979) were selected to evaluate in situ degradation kinetics of protein fractions including true protein (TP), neutral-detergent insoluble protein (NDIP) and acid-detergent insoluble protein (ADIP) of various oilseed meals (cottonseed meal (CSM), soyabean meal (SM) and rapeseed meal (RM)).
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Shimozono, Yoshiharu, Eoghan Hurley und John Kennedy. „Mid-term Outcomes of Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus“. Foot & Ankle Orthopaedics 3, Nr. 3 (01.07.2018): 2473011418S0044. http://dx.doi.org/10.1177/2473011418s00444.
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Category: Ankle Introduction/Purpose: Autologous osteochondral transplantation (AOT) is an established treatment for large-sized OLT, typically greater than 107mm2. Several studies have demonstrated favourable outcomes following AOT at short- and mid-term follow-up. However, the majority of the literature on AOT has short-term follow-up and little evidence exists on the mid-term and longer-term follow-up. Additionally, few studies include a large number of patients or have a high level of evidence, limiting the ability to draw broad and meaningful conclusions about the effectiveness of the AOT procedure for the treatment of OLT beyond short-term follow-up. The purpose of the current systematic review was to evaluate the clinical outcomes analysing level and quality of evidence of the AOT procedure in the treatment of OLT at mid-term and long-term follow-up. Methods: A systematic search of the MEDLINE, EMBASE and Cochrane Library databases was performed in October 2017 based on the PRISMA guidelines. Included studies were evaluated with regard to level of evidence (LOE) and quality of evidence (QOE) using the Coleman Methodology Score. Clinical outcomes, and complications were also evaluated. Results: Eleven studies, with 500 ankles were included at a mean 62.8 months follow-up. There were 3 studies of LOE III, and 8 studies of LOE IV. There were 3 studies of fair quality and 8 studies of poor quality. The weighted mean preoperative AOFAS score was 55.1 ± 6.1, and the postoperative score was 86.2 ± 4.5, with 87.4% of patients being reported as excellent or good results. In total, 54 of the 500 patients (10.8%) had complications. The most common complication was donor site morbidity with 18 patients (3.6%) at final follow-up. Thirty-one patients (6.2%) underwent reoperations, and the authors deemed a total of 5 ankles (1.0%) failures. Only 5 studies (45.5%) used MRI for follow-up evaluation. Conclusion: The current systematic review demonstrated that good clinical and functional outcomes can be expected following AOT procedure for the treatment of OLT, with a failure rate of only 1.0% at 63 months follow-up. MRI and radiographs showed restoration of articular surface as well as a minimal presence of osteoarthritis at mid-term follow-up. However, there is still lack of data from high LOE and QOE studies, and further high quality studies are necessary.
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Brock, Justin A., Jason J. Griffin und Cheryl R. Boyer. „Rooting Stem Cuttings of Herbaceous and Woody Ornamentals in Substrates Containing Eastern Redcedar (Juniperus virginiana)“. Journal of Environmental Horticulture 33, Nr. 4 (01.12.2015): 155–59. http://dx.doi.org/10.24266/0738-2898-33.4.155.
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Propagation substrates can strongly influence rooting success of stem cuttings. Eastern redcedar (Juniperus virginiana L.) chips (ERC) have been suggested as a propagation substrate component. This study investigated ERC as a perlite substitute in a perlite:sphagnum peat moss (3:1 v/v) rooting substrate. Stem cuttings of coleus [Solenostemon scutellarioides (L.) Codd], English ivy (Hedera helix L.), forsythia (Forsythia ×intermedia Zab.), lantana (Lantana camara L.), and spreading euonymus (Euonymus kiautschovicus Loes.) were rooted in substrates containing increasing concentrations of ERC hammer-milled to pass a 4.8 mm (0.19 in) screen. All species rooted well (≥ 95%) in all substrates except forsythia which rooted poorly in all substrates (8 to 36%). ERC concentration did not affect mean root number or mean root length in any species except spreading euonymus where mean root number peaked at 0 and 100% ERC content and mean root length decreased with increasing ERC content. Bulk density, container capacity, and total porosity increased as ERC replaced perlite. Physical properties of all substrates were suitable for cutting propagation. ERC can effectively replace perlite in rooting substrates for many ornamental species.
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Guo, Jingjing, Miriam Glendell, Jeroen Meersmans, Frédérique Kirkels, Jack J. Middelburg und Francien Peterse. „Assessing branched tetraether lipids as tracers of soil organic carbon transport through the Carminowe Creek catchment (southwest England)“. Biogeosciences 17, Nr. 12 (24.06.2020): 3183–201. http://dx.doi.org/10.5194/bg-17-3183-2020.
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Abstract. Soils represent the largest reservoir of organic carbon (OC) on land. Upon mobilization, this OC is either returned to the atmosphere as carbon dioxide (CO2) or transported and ultimately locked into (marine) sediments, where it will act as a long-term sink of atmospheric CO2. These fluxes of soil OC are, however, difficult to evaluate, mostly due to the lack of a soil-specific tracer. In this study, a suite of branched glycerol dialkyl glycerol tetraethers (brGDGTs), which are membrane lipids of soil bacteria, is tested as specific tracers for soil OC from source (soils under arable land, ley, grassland, and woodland) to sink (Loe Pool sediments) in a small catchment located in southwest England (i.e. Carminowe Creek draining into Loe Pool). The analysis of brGDGTs in catchment soils reveals that their distribution is not significantly different across different land use types (p>0.05) and thus does not allow land-use-specific soil contributions to Loe Pool sediments to be traced. Furthermore, the significantly higher contribution of 6-methyl brGDGT isomers in creek sediments (isomerization ratio (IR) = 0.48±0.10, mean ± standard deviation (SD); p<0.05) compared to that in catchment soils (IR = 0.28±0.11) indicates that the initial soil signal is substantially altered by brGDGT produced in situ. Similarly, the riverine brGDGT signal appears to be overwritten by lacustrine brGDGTs in the lake sedimentary record, indicated by remarkably lower methylation of branched tetraethers (MBT5ME′=0.46±0.02 in creek bed sediments and 0.38±0.01 in lake core sediments; p<0.05) and a higher degree of cyclization (DC = 0.23±0.02 in creek bed sediments and 0.32±0.08 in lake core sediments). Thus, in this small catchment, brGDGTs do not allow us to trace soil OC transport. Nevertheless, the downcore changes in the degree of cyclization and the abundance of isoprenoid GDGTs produced by methanogens in the Loe Pool sediment do reflect local environmental conditions over the past 100 years and have recorded the eutrophication history of the lake.
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Singngam, Sorakrit. „THE MENAGEMENT MODEL FOR DEVELOPMENT TO QUALITY SCHOOL OF BAN KHONKEANNONSAWAN SCHOOL (SMARTS MODEL) UNDER THE LOEI PRIMARY EDCATIONAL SERVICE AREA OFFICE 2“. Journal Universitas Muhammadiyah Gresik Engineering, Social Science, and Health International Conference (UMGESHIC) 1, Nr. 2 (25.12.2021): 856. http://dx.doi.org/10.30587/umgeshic.v1i2.3464.
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The objectives of this article were to create to implement and to evaluate the management model for development to quality schools of Ban Khonkeannonsawan school under the Loei Primary Educational Service Area Office 2 by 3 steps of research and developmentmethodology; (1) creating the management model by literature reviewing, the scholars interview, drafting the models suitability and feasibility assessment by 7 the academic experts. The data were collected by interviewing and questionnaires. (2) experimenting the management model in the first semester of academic year 2020 by 20 teachers and 190 students. The research tools were the model manual, questionnaires and summary form. (3) evaluating the management model. The data was collected from 9 teachers by questionnaire. The statistics used for data analysis were mean and standard deviation. The finding showed as follow: (1) The management model for development to quality schools of Ban Khonkeannonsawan school under the Loei Primary Educational Service Area Office 2 consist of 6 elements; (a) Principle, (b) objectives, (c) 7 quality school elements (d) 7 steps of the management process (e) outputs and (f) success factors and the management model’s suitability and feasibility in overall were the highest level. (2) The implement results the management model showed the self-assessment based on the quality school elements was high level, the students had higher academic achievement than academic year 2019 and the stakeholders satisfaction in overall were the highest level (
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Chomphara, Nattharacha, Siriphon Srichantha, Atikhun Sintanapanya und Supachai Srichantha. „Satisfaction of students toward using test retest method in reading and writing skills for Thai word“. Journal of Green Learning 1, Nr. 2 (31.12.2021): 49–51. http://dx.doi.org/10.53889/jgl.v1i2.44.
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This research study was aimed at the satisfaction of students toward using the test retest method in course Reading and Writing Skills for Thai Word. The research samples consisted of 44 students who were students at Loei Rajabhat University. The research instrument was a questionnaire. Data were analyzed with percentage, mean, and standard deviation. The result showed that the satisfaction level of students toward using the test-retest method in Reading and Writing Skills for Thai Word in overall aspects were at high level. They are ready to improve their learning achievement and language skills. The program or workshop for continuing in such knowledge and language skills need to be prepared in the appropriate contexts.
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Ramponi, Laura, Youichi Yasui, Christopher D. Murawski, Richard D. Ferkel, Christopher W. DiGiovanni, Gino M. M. J. Kerkhoffs, James D. F. Calder et al. „Lesion Size Is a Predictor of Clinical Outcomes After Bone Marrow Stimulation for Osteochondral Lesions of the Talus: A Systematic Review“. American Journal of Sports Medicine 45, Nr. 7 (16.11.2016): 1698–705. http://dx.doi.org/10.1177/0363546516668292.
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Background: The critical lesion size treated with bone marrow stimulation (BMS) for osteochondral lesions of the talus (OLTs) has been 150 mm2 in area or 15 mm in diameter. However, recent investigations have failed to detect a significant correlation between the lesion size and clinical outcomes after BMS for OLTs. Purpose: To systematically review clinical studies reporting both the lesion size and clinical outcomes after BMS for OLTs. Study Design: Systematic review. Methods: A systematic search of the MEDLINE and EMBASE databases was performed in March 2015 based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Included studies were evaluated with regard to the level of evidence (LOE), quality of evidence (QOE), lesion size, and clinical outcomes. Results: Twenty-five studies with 1868 ankles were included; 88% were either LOE 3 or 4, and 96% did not have good QOE. The mean area was 103.8 ± 10.2 mm2 in 20 studies, and the mean diameter was 10.0 ± 3.2 mm in 5 studies. The mean American Orthopaedic Foot and Ankle Society score improved from 62.4 ± 7.9 preoperatively to 83.9 ± 9.2 at a mean 54.1-month follow-up in 14 studies reporting both preoperative and postoperative scores with a mean follow-up of more than 2 years. A significant correlation was found in 3 studies, with a mean lesion area of 107.4 ± 10.4 mm2, while none was reported in 8 studies, with a mean lesion area of 85.3 ± 9.2 mm2. The lesion diameter significantly correlated with clinical outcomes in 2 studies (mean diameter, 10.2 ± 3.2 mm), whereas none was found in 2 studies (mean diameter, 8.8 ± 0.0 mm). However, the reported lesion size measurement method and evaluation method of clinical outcomes widely varied among the studies. Conclusion: An assessment of the currently available data does suggest that BMS may best be reserved for OLT sizes less than 107.4 mm2 in area and/or 10.2 mm in diameter. Future development in legitimate prognostic size guidelines based on high-quality evidence that correlate with outcomes will surely provide patients with the best potential for successful long-term outcomes.
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Ubillus, Hugo A., Mohammad T. Azam, Matthew B. Weiss, Noah Kirschner, Nathaniel P. Mercer, James J. Butler und John G. Kennedy. „Surgical Management of Chronic Achilles Tendon Rupture: A Systematic Review and Proposed Treatment Algorithm“. Foot & Ankle Orthopaedics 7, Nr. 4 (Oktober 2022): 2473011421S0098. http://dx.doi.org/10.1177/2473011421s00982.
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Category: Sports; Other Introduction/Purpose: The Achilles tendon is the most commonly ruptured tendon in the lower limb, and when left untreated for at least 4 weeks, these are classified as chronic or 'neglected' Achilles tendon ruptures (CATR). There is discordance on the optimal surgical treatment to treat CATR. Given the prevalence of this injury, there is a need to determine the best treatment modality. In this study, we performed a systematic review of the literature to compare the different treatment options for CATR, analyze the level of evidence (LOE) and quality of evidence (QOE) of the included studies, and recommend a literature-based algorithmic approach to the treatment of CATR. Methods: In July 2019, MEDLINE, EMBASE, and Cochrane Library databases were systematically reviewed by 2 independent reviewers based on the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Full-length peer-reviewed studies in English with a sample size of 10 participants that reported functional outcome scores with a minimum follow-up of 24 months were included. We excluded systematic reviews, meta-analyses, review articles, cadaveric and animal studies, and case reports. The LOE and QOE of the included studies were evaluated using the Journal of Bone and Joint Surgery Criteria and the Modified Coleman Methodology Score, respectively. Patient demographic data, surgical procedure type, subjective outcomes, postoperative strength, range of motion, postoperative imaging, return to sports and work data, complications, failures, and reoperations were evaluated. Continuous variables were reported as weighted mean and estimated standard deviation, whereas categorical variables were reported as frequencies with percentages. Results: Thirty-one studies with 653 CATRs were included. Three studies were LOE III and 28 studies were LOE IV. A large variety of repair techniques were described and analyzed, and semitendinosus tendon grafting was the most frequently utilized technique (6 of 31 studies). The most commonly reported clinical outcome was the American Orthopaedic Foot and Ankle Society (AOFAS) score (58.6%). Most studies reported good postoperative subjective outcomes, strength outcomes, and return to sports data at mid-term follow-up. In total, 14.6% of patients experienced postoperative complications, where the most common was surgical wound complications (10.8%). Conclusion: Surgical management of CATR produces good clinical outcomes at mid-term follow-up, but a high complication rate (14.6%) was noted. This systematic review found that no evidence-based treatment guidelines exist for CATR. Future studies of higher QOE and LOE which focus on specific risk factors are warranted to determine in which case one particular technique would be suitable for CATR repair. Our proposed treatment algorithm (Figure 1) may assist in shared decision-making for this complex problem.
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Garg, Heena, Purva Makhija, Dhruv Jain, Shailendra Kumar und Lokesh Kashyap. „Comparison of the classical approach and costoclavicular approach of ultrasound-guided infraclavicular block: A systematic review and meta-analysis“. Indian Journal of Anaesthesia 68, Nr. 7 (07.06.2024): 606–15. http://dx.doi.org/10.4103/ija.ija_1124_23.
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Background and Aims: The infraclavicular brachial plexus block (ICB) provides analgesia and anaesthesia of the upper limb. It is given using the classical or the more recently described costoclavicular (CC) approach at the level of cords. This systematic review aimed to assess which approach is better for the ICB in terms of onset, performance, and safety. Methods: This PROSPERO (vide registration number CRD42022361636) registered meta-analysis included randomised trials of patients undergoing upper limb surgery in ultrasound-guided ICB from MEDLINE, EMBASE, SCOPUS, and IRCTP from inception to March 2023. The quality of evidence was assessed using GradePro software. The primary outcomes were sensory and motor block onset time and the number of patients having complete block at 30 minutes. Secondary outcomes included block performance time (BPT), number of attempts, duration of the block, and any incidence of complications. Results: Five trials with 374 adult patients (classic = 185, CC = 189) were included. No significant difference was found in the sensory (Mean difference (MD): 1.44 minutes [95% confidence interval (CI): 3.06, 5.95]; I2 = 95%; very low level of evidence (LOE); P = 0.53) and motor block onset times (MD: 0.83 minutes [95% CI: 0.96, 2.62]; I2 = 84%; very low LOE P = 0.36) and BPT (MD: 5.06 seconds [95% CI: 38.50, 48.63]; I2 = 98%; very low LOE; P = 0.82) in classic and CC approach of ICB. Trial sequential analysis revealed our sample size to be 0.65% of the required sample size to achieve 80% power, deeming our study underpowered. Conclusion: Costoclavicular approach was not superior or inferior to the classical technique for infraclavicular brachial plexus block. However, the quality of evidence is low and further studies are needed to corroborate the findings.
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ALMASE, Veronica. „Microfinance Institutions (MFIs) Intervention in Poverty Alleviation of Households in Lopez, Quezon Province, Philippines“. Psychology and Education Journal 58, Nr. 1 (15.01.2021): 3625–31. http://dx.doi.org/10.17762/pae.v58i1.1350.
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This paper investigates Microfinance Institutions (MFIs) Intervention in poverty alleviation of households in the locality of Lopez, Quezon province, Philippines. It focuses on five specific objectives to: Determine the personal profile of MFIs household members, their membership profile, examine the goal congruence between MFIs and households, investigate the circumstances during MFIs intervention and, finally find out threats in availing loans from MFIs. This paper adopts quantitative type of research primarily the descriptive questions survey where 117 were considered as the representative sample of MFIs in the municipality. Likewise, purposive sampling was used in the determination of samples and survey form for data collection. This study utilized the SPSS to generate the frequency distribution and weighted mean. It was revealed in the analysis that microfinance interventions that offer both savings and loans contributed to a higher standard of living of households. More so, the results show that microfinance institutions provide supplemental income for families which may adhere to basic family needs, health, education, and lessen debts to specific persons. Therefore, It was found out that both microfinance savings and microfinance credit appreciably and undoubtedly changed the conditions of every household after availing the MFIs services. The study recommends that MFIs should continuously pay closer attention on their interventions that will provide assistance that are favorable to the welfare of every member and the society as well.
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Börke Tunalı, Çiğdem, und Naci Tolga Saruç. „An Empirical Analysis on the Relationship between Health Care Expenditures and Economic Growth in the European Union Countries“. European Journal of Medicine and Natural Sciences 2, Nr. 1 (02.03.2018): 12. http://dx.doi.org/10.26417/ejmn.v2i1.p12-17.
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This paper empirically investigates the relationship between health expenditure and economic growth in the European Union countries over the period 1995-2014. By using the Dumitrescu-Hurlin Test (Dumitrescu and Hurlin, 2012) which is developed to test Granger causality in panel datasets (Lopez and Weber, 2017), it is found that there is a unidirectional relationship between these variables and gross domestic product (GDP) per capita Granger causes health expenditure per capita. After determining the direction of the relationship between health expenditure per capita and GDP per capita we estimate the short run and the long run effects of GDP per capita on health expenditure per capita by using Mean Group (MG) and Pooled Mean Group (PMG) estimators which are developed by Pesaran and Smith (1995) and Pesaran, Shin and Smith (1999) respectively. According to the estimation results, GDP per capita has a positive effect on health expenditure per capita both in the short run and the long run.
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Börke Tunalı, Çiğdem, und Naci Tolga Saruç. „An Empirical Analysis on the Relationship between Health Care Expenditures and Economic Growth in the European Union Countries“. European Journal of Medicine and Natural Sciences 4, Nr. 2 (15.10.2021): 11. http://dx.doi.org/10.26417/682jde51h.
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This paper empirically investigates the relationship between health expenditure and economic growth in the European Union countries over the period 1995-2014. By using the Dumitrescu-Hurlin Test (Dumitrescu and Hurlin, 2012) which is developed to test Granger causality in panel datasets (Lopez and Weber, 2017), it is found that there is a unidirectional relationship between these variables and gross domestic product (GDP) per capita Granger causes health expenditure per capita. After determining the direction of the relationship between health expenditure per capita and GDP per capita we estimate the short run and the long run effects of GDP per capita on health expenditure per capita by using Mean Group (MG) and Pooled Mean Group (PMG) estimators which are developed by Pesaran and Smith (1995) and Pesaran, Shin and Smith (1999) respectively. According to the estimation results, GDP per capita has a positive effect on health expenditure per capita both in the short run and the long run.
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Institóris, L., O. Siroki, Ü. Ündeger, N. Basaran und I. Dési. „Immunotoxicological investigations on rats treated subacutely with dimethoate, As3+and Hg2+ in combination“. Human & Experimental Toxicology 20, Nr. 7 (Juli 2001): 329–36. http://dx.doi.org/10.1191/096032701680350569.
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Effects of combined exposure with dimethoate (DM), HgCl2(Hg),andNaAsO2 (As)wereinvestigatedfollowinga28-day oral exposure in male Wistar rats. In preliminary experiments, the LOEL (Lowest Observed Effect Level) and NOEL (Non Observed Effect Level) doses of the substances were determined using the same experimental system [determination of body weight gain, organ weights of brain, thymus, heart, lung, kidneys, adrenals, spleen, testicles, popliteal lymph node, white blood cell (WBC) and red blood cell (RBC) count, haematocrit (Ht), mean cell volume (MCV) of RBCs, cell content of the femoral bone marrow, IgM-plaque forming cell (PFC) content of the spleen, delayed type hypersensitivity (DTH) reaction] and animal strain. In the combination studies, LOEL dose of DM (28.2 mg/kg) was combinedwithNOELdosesoftheheavymetals(HgCl2 =0.40 mg/kg, NaAsO2 =3.33 mg/kg), and vice versa (DM=7.04 mg/kg, HgCl2 =3.20 mg/kg, NaAsO2 =13.3 mg/kg). In the DM–Hg combinations, significant alterations were found versus the corresponding high-dose internal control in the body weight gain, relative liver and kidney weights, and in the PFC response. When DM was combined with As, interactions were indicated by changes of relative liver weight, MCV value, and the PFC content of the spleen. These results support the theory that the interactions between pesticides and heavy metals may modify the toxic effects of the single substances, and may also change the functional detection limits of the exposure. The changes in the functional detection limits, if they occur, can lead to false-positive and false-negative results in human epidemiological studies.
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Qato, Khalil, Allan Conway, Eileen Lu, Nhan Nguyen Tran, Gary Giangola und Alfio Carroccio. „Outcomes of Thoracic Endovascular Aneurysm Repair (TEVAR) in Patients With Connective Tissue Disorders“. Vascular and Endovascular Surgery 54, Nr. 8 (30.07.2020): 676–80. http://dx.doi.org/10.1177/1538574420945070.
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Objectives: Thoracic endovascular aortic repair (TEVAR) remains controversial in patients with connective tissue disorders given the concern for durability. We report on the largest series to date on outcomes of patients with thoracic aortic disease and connective tissue disorders treated with TEVAR. Methods: The Vascular Quality Initiative registry identified 12 207 patients treated with TEVAR from January 2010 to December 2018, including 102 with Marfans, Ehlers-Danlos, or Loey-Dietz syndrome. Outcomes were analyzed per the Society for Vascular Surgery reporting standards. Results: Median age was 50.6 years (interquartile range: 57.0-75.0), and 62 (60.7%) were male. Eighty-eight (86.3%) patients had Marfan, 9 (8.8%) had Ehlers-Danlos, and 5 (4.9%) had Loey-Dietz syndrome. Twenty-six (25.5%) patients were treated for degenerative aneurysmal disease and 76 (74.5%) patients for type B dissections (33 acute, 31 chronic). Most common indications for interventions in patients with type B dissection were pain (n = 41), aneurysmal degeneration (n = 16), and malperfusion (n = 8), with 3 patients who presented ruptured. There was no significant difference in perioperative complications between acute/chronic dissections and aneurysms ( P = .14). Percutaneous access was utilized in 61.7% of patients, with a 2.9% rate of arterial injury requiring reintervention. Follow-up data were available for 75 (73.3%) patients at a mean follow-up of 15.6 months. Overall mortality was 5.3%. There were 30 patients with follow-up endoleak data, and 8 (26.7%) endoleaks were identified. All endoleaks were in patients treated for acute type B dissection, and all resolved after a mean of 2.1 reinterventions. Three patients treated for acute Type B Aortic Dissection (TBAD) had retrograde dissections requiring intervention. Discussion: Thoracic endovascular aortic repair for patients with connective tissue disorders can be performed with low perioperative mortality, spinal cord ischemia, or Cerebrovascular Accident (CVA). On follow-up, acute type B aortic dissections represent a higher risk subgroup with increased rates of endoleak and retrograde dissection. Closer follow-up for these patients and early reintervention may be beneficial.
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Gopinath, Vellore Kannan, Betul Rahman und Manal A. Awad. „Assessment of gingival health among school children in Sharjah, United Arab Emirates“. European Journal of Dentistry 09, Nr. 01 (Januar 2015): 036–40. http://dx.doi.org/10.4103/1305-7456.149636.
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ABSTRACT Objectives: The present study evaluated the gingival condition among school going children in Sharjah, United Arab Emirates and determined its relationship with tooth brushing frequency, diet and dental caries. Materials and Methods: Four hundred and five children participated in the study. There were 232 boys (57%) and 173 (43%) girls. Children were grouped based on age as ≤6 years (n = 84) mean age 4.72 ± 0.50 and >6 years (n = 321) mean age 8.47 ± 1.65. The amount of dental plaque and gingival condition were assessed on the inner and outer surface of six index teeth using Silness and Loe and Loe and Silness criteria. Dental caries status was assessed using WHO 1997 criteria. Dental examination, tooth brushing frequency and 24 h diet chart were recorded by calibrated dentists. Logistic regression analysis was used to determine the predictors of gingivitis. Results: Increase in decayed, missing, and filled teeth values corresponds to increase in plaque index and gingival index scores (P ≤ 0.05). A logistic regression analysis of the predictors of gingivitis showed that males were 2.11 times less likely to have gingivitis compared with females (odds ratio [OR]: 0.47, 95% confidence interval [CI]: 0.24-0.93, P = 0.03) and children aged ≤6 years were 3.06 times less likely to have gingivitis than those aged >6 years (OR: 0.33, 95% CI: 0.17-0.62, P = 0.00). Tooth brushing frequency and diet were not significant predictors. Conclusion: Current study clearly demonstrated that female gender and children more than 6 years were more likely to have gingivitis.
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Irfan, Abdullah, Muhammad Moin und Adeel Chaudhry. „TEACHING OPHTHALMOSCOPY WITH DIRECT OPHTHALMOSCOPE VS ARCLIGHT OPHTHALMOSCOPE IN POST-GRADUATE NON-OPHTHALMOLOGY RESIDENTS“. Pakistan Postgraduate Medical Journal 30, Nr. 02 (03.11.2020): 69–73. http://dx.doi.org/10.51642/ppmj.v30i02.284.
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Purpose: To compare the ease of use, perceived duration of examination and patient comfort during fundoscopy using Arclight ophthalmoscope against conventional direct ophthalmoscope.
Study Design: Comparative Cross Sectional
Sampling Technique: Purposive Sampling Technique
Place & Duration of Study: This study was executed during two workshop sessions of 180 minutes each held in 2019 at Ophthalmology department of Lahore General Hospital, Lahore.
Material &Methods: Post Graduate residents from different departments of Lahore general hospital were invited over to participate in hands On workshop. Participants were given a brief review of fundoscopy techniques and response booklets were given to them for noting down their findings. Patients with variable Vertical Cup to disc ratio (VCDR) had their pupils pharmacologically dilated for participants to examine the fundus. After successful collection of data from 74 post graduates in two sessions, it was compiled and used to draw statistically significant descriptive and inferential results.
Results : During this teaching experience in form of workshop , the scores from both devices were used and correlation was positive ( Pearson Correlation value = 0.712) and significant (p-value = 0.000). It was seen that mean Ease of use score for Direct Ophthalmoscope was 6.0 (± 1.345) while the mean of EOU for Arclight was 6.23 (± 1.193) showing that ease of use by the examiners for both devices was almost same, however Arclight was slightly easier to use and handle. Patients perceived slightly less glare and more comfort during examination with Arclight (Mean Comfort Score = 3.27 ± 0.703) as compared to standard direct ophthalmoscope (Mean Comfort Score = 3.0 ± 0.617). Duration of examination perceived by the subjects was uncomfortably long with Direct Ophthalmoscope (Mean LOE Score 2.77 ± 0.685) , while it was relatively shorter with Arclight (Mean LOE Score = 3.18 ± 0.664).
Conclusion : In addition to being cost effective and a compact instrument, Arclight is slightly easier to use with a shorter learning curve for the beginners. It is better tolerated by patients hence providing more comfort during examination in terms of glare. The length of examination as perceived by the patients, is also much shorter for Arclight as compared to standard direct ophthalmoscope.
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Pence, Michael A., Dylan G. Boucher, Zachary A. Nguyen, Joaquin Rodriguez Lopez und Shelley D. Minteer. „Autonomous and Closed-Loop Exploration and Optimization of Bioelectrocatalytic Systems“. ECS Meeting Abstracts MA2024-02, Nr. 54 (22.11.2024): 3664. https://doi.org/10.1149/ma2024-02543664mtgabs.
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Automated electrochemistry platforms provide a pathway for speeding up the discovery and optimization of electrochemical systems, especially when a broad range of molecules and reaction conditions must be explored.1-3 Additionally, incorporation of machine learning enables closed-loop optimization campaigns, where the obtained experimental data guides the selection of the next set of experimental parameters to test. This type of autonomous exploration is ideally suited for the study of enzyme electrocatalysis, as the combinatorics of different enzymes, substrates, and redox mediators creates a prohibitively large parameter space. Even within a single enzyme class, mutations to the amino acid sequence can significantly impact rate, function, and selectivity of the catalyzed reaction. Thus, an automated electrochemical platform that enables rapid sampling both reaction parameters and amino acid sequence space would enable discovery of new, non-native enzymatic reactions. In this work we use an open source and modular automated electrochemistry platform to study enzyme electrocatalysis in several common bioelectrocatalytic systems, such as glucose oxidase, glucose dehydrogenase, and aldehyde dehydrogenase. We use automated cyclic voltammetric substrate titration experiments (Figure 1) to gain insight into the kinetics of the redox-mediated enzymatic catalysis and demonstrate the reaction conditions in which traditional mechanistic simplifications, like Michaelis-Menten, break down. Additionally, the automated electrochemistry platform allows for the rapid screening of different substrate molecules, enabling the quantification of substrate promiscuity in these enzymatic catalysts. We show how Bayesian Optimization can be incorporated into our workflow to autonomously tune solution parameters to promote increased reaction rates. These studies demonstrate the power of autonomous electrochemistry for understanding and screening biocatalytic systems and represent a significant step towards totally machine-guided biocatalyst evolution. [1] Oh, I. ; Pence, M. A.; Lukhanin, N.; Rodriguez, O.; Schroeder, C. M.*; Rodriguez-Lopez, J.*, “The Electrolab: An open-source, modular platform for automated characterization of redox-active electrolytes” Device, 2023, 1, 5, 100103 [2] Rodriguez, O.; Pence, M. A.; Rodriguez-Lopez, J.*, “Hard Potato: An Open Source Python Library to Control Commercially Available Potentiostats and Automate Electrochemical Experiments” Anal. Chem., 2023, 95, 4840–4845 [3]Pence, M. A.; Rodriguez, O.; Lukhanin, N.; Schroeder, C. M.*; Rodriguez-Lopez, J.*, “Automated Measurement of Electrogenerated Redox Species Degradation Using Multiplexed Interdigitated Electrode Arrays”, ACS Meas. Sci. Au, 2023, 3, 62–72 Figure 1
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Santanapipatkul, Krit, und Wilairak Jantakun. „Development and validation of a score for the screening of Loei urolithiasis patients“. Insight Urology 43, Nr. 1 (17.06.2022): 13–24. http://dx.doi.org/10.52786/isu.a.44.
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Objective: To evaluate risk factors associated with stone formation and development and validation of a score for screening Loei urolithiasis patients. Materials and Methods: This cross-sectional study included 1008 individuals, 466 of which were urolithiasis patients and 542 non-urolithiasis, with no history of stone and no evidence of stone from investigations at Loei Hospital between July 2014 and January 2019. This group was used effectively as a control group. Questionnaires were used to collect information regarding demographic parameters, food and water intake and frequency. The information was used to identify any associations with stone formation using logistic regression analysis. Univariable and multivariable analysis were carried out in order to build a predictive model for the likelihood of stone formation. The strength of the classifier from the predictive model was evaluated using the area under the receiver operating characteristics (ROC) curve. Results: Multivariable analysis showed increasing BMI (adjusted odds ratio (aOR) =1.06; 95% CI: 1.01-1.1, p = 0.01); male gender (aOR = 2.09; 95%CI: 1.46-2.98, p < 0.001); family history of urolithiasis (a OR = 2.81; 95% CI: 1.78-4.42, p < 0.001); farmer (aOR = 3.59; 95% CI: 2.44-5.29, p < 0.001); working time > 8 hours/day (aOR = 2.19; 95%CI: 1.47-3.27, p < 0.001); drinking more than 2 liters per day of water (aOR = 1.58; 95%CI: 1.13-2.22, p = 0.01); always eat water spinach (aOR = 3.37; 95% CI: 1.47-7.74, p = 0.01); always eat bamboo shoots (aOR = 9.53; 95% CI: 4.54-19.99, p < 0.001); eat Laab/Koi (a local Thai spicy salad made of raw meat and fish) more than or equal to 3 times per week (aOR = 1.75; 95% CI: 1.05-2.9, p = 0.03) and drink bottled water (aOR = 0.17.; 95% CI: 0.12-0.24, p < 0.001) were statistically significant for stone formation. The predictive model for the likelihood of stone formation has a cut-off value greater than or equal to 0.46 for a sensitivity of 72.41%, a specificity of 79.52%, and area under the ROC curve of 0.83. Conclusions: Increasing BMI, being of male gender, a family history of urolithiasis, farmers, working time > 8 hours/day, regular consumption of water spinach, regular consumption of bamboo shoots, eat Laab/Koi more than or equal to 3 times per week were associated significantly with stone formation. We developed and validated a predictive model to indicate the likelihood of stone formation, which can be utilized for the screening of Loei urolithiasis patients facilitating early detection and early treatment.
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NOWAKOWSKA, D., W. WUJCICKA, W. SOBALA, E. ŚPIEWAK, Z. GAJ und J. WILCZYŃSKI. „Age-associated prevalence ofToxoplasma gondiiin 8281 pregnant women in Poland between 2004 and 2012“. Epidemiology and Infection 142, Nr. 3 (31.05.2013): 656–61. http://dx.doi.org/10.1017/s0950268813001179.
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SUMMARYThis study aimed to describeToxoplasma gondiiprevalence in Polish pregnant women and the incidence rates of congenital infections in their neonates observed between 2004 and 2012. Serological tests forT. gondii-specific IgG and IgM antibodies were performed on serum samples of 8281 pregnant women treated at the Polish Mother's Memorial Hospital Research Institute in Lodz. The yearly seroconversion rate forT. gondiiIgG antibodies was estimated using a mathematical model to determine the dependency between age and prevalence. Mean prevalence of IgG antibodies between 2004 and 2012 in pregnant women was 40·6% [95% confidence interval (CI) 39·6–41·7] and increased with age with a yearly seroconversion rate of 0·8% (95% CI 0·6–1·0,P < 0·001). Assuming aT. gondiimaterno-fetal transmission rate of 30% gave an estimate of 1·80/1000 neonates as congenitally infected. The increased mean age (28·7vs26·7 years,P < 0·001) of pregnant women was probably the most important factor in abolishing the effect of falling prevalence rates.
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Raudys, Aistis, und Edvinas Goldstein. „Forecasting Detrended Volatility Risk and Financial Price Series Using LSTM Neural Networks and XGBoost Regressor“. Journal of Risk and Financial Management 15, Nr. 12 (13.12.2022): 602. http://dx.doi.org/10.3390/jrfm15120602.
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It is common practice to employ returns, price differences or log returns for financial risk estimation and time series forecasting. In De Prado’s 2018 book, it was argued that by using returns we lose memory of time series. In order to verify this statement, we examined the differences between fractional differencing and logarithmic transformations and their impact on data memory. We employed LSTM (long short-term memory) recurrent neural networks and an XGBoost regressor on the data using those transformations. We forecasted risk (volatility) and price value and compared the results of all models using original, unmodified prices. From the results, models showed that, on average, a logarithmic transformation achieved better volatility predictions in terms of mean squared error and accuracy. Logarithmic transformation was the most promising transformation in terms of profitability. Our results were controversial to Marco Lopez de Prado’s suggestion, as we managed to achieve the most accurate volatility predictions in terms of mean squared error and accuracy using logarithmic transformation instead of fractional differencing. This transformation was also most promising in terms of profitability.
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Jaiswal, Rajeev K., Deepti Chandra, Md Arif Khan, Sanjay Gupta, Piyush Gowrav und Surendra Kumar Yadav. „Clinical Evaluation of Coronally Advanced Flap with or without a Platelet-Rich Fibrin Membrane for the Root Coverage“. Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (Februar 2024): S320—S323. http://dx.doi.org/10.4103/jpbs.jpbs_509_23.
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ABSTRACT Aim: To evaluate “coronally advanced flap” with or without “a platelet-rich fibrin membrane for the root coverage.” Materials and Methods: All the clinical parameters were assessed at different time intervals (at baseline, 1, 3, and 6 months) in both experimental and control group. Following “clinical parameters” were recorded using “UNC-15” “Probe-Plaque Index (PI)” (Silness and Loe, 1964), “Gingival Index” (GI) (Loe and Silness, 1963), “Recession depth (RD),” “Recession width (RW),” “Clinical attachment level (CAL),” and “Width of keratinized gingiva (WKG)”. Results: At final evaluation (i.e., mean change from baseline to 6 months), “the decrease in Plaque Index was 2.5% higher in Group B (66.0%) as compared to Group A (63.5%). The decrease in Gingival Index was 6.1% higher in Group B (91.4%) as compared to Group A (85.3%), and the decrease in recession width was 4.0% higher in Group B (75.2%) as compared to Group A (71.2%). The decrease in clinical attachment level was 4.4% higher in Group B (53.2%) as compared to Group A (48.4%). The increase in width of keratinized gingiva was 1.9% higher in Group A (28.8%) as compared to Group B (26.9%).” Conclusion: The controlled, randomized, split mouth design showed that CAF surgery, either by alone or in combination with PRF, is an efficient treatment method for covering denuded roots. “This design was used to treat bilateral isolated Miller’s class I and II recessions in gingival part. When compared to the CAF approach, the results from a combination of CAF and PRF after a 6-month period showed additional advantages in addition to mean root coverage in the treatment of Miller’s classes I and II recessions in gingival part.”