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1
Bustos, Anne-Marie. „Un environnement OSI autour du compilateur ASN. 1 MAVROS“. Nice, 1992. http://www.theses.fr/1992NICE4560.
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Hamáček, Vojtěch. „Vývoj bezpilotního prostředku pro autonomní mise“. Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442528.
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The aim of this thesis is to modify commercially produced drone DJI Matrice 100 and replace its original control unit by open source Pixhawk and its accessories. Subsequently, it deals with the selection of suitable open source firmware for Pixhawk and its configuration on the device. Another part is dedicated to the possibilities of using the Robotic Operating System (ROS) and its Mavros libraries on the onboard computer Raspberry Pi. By using Mavros, it examines the possibilities of drone flight control, both in the simulation environment and in the real environment.
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Sanchez, Julian. „The Various Agendas of Market Mavens“. Honors in the Major Thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1189.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Business Administration
Marketing
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Cicileo, Francesca Rose. „Mavo Create : a WYSIWYG editor for Mavo“. Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119759.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (page 47).
Mavo Create provides the data storage and computation abilities of Mavo through the interface of a WYSIWYG (What-You-See-Is-What-You-Get) editor. Mavo extends HTML, providing attributes that one can use to set up data storage for a web application. This data can be created, amended, and populated into the web application use Mavo attributes. Further, Mavo provides expressions for performing computations on the data and visualizing the results of those computations in the Mavo application. One limitation of Mavo is that a user must know or become familiar with HTML in order to use Mavo. Mavo Create attempts to abstract away the programming part of using Mavo by providing a visual website editor that can be used to create Mavo applications. Mavo Create was built using GrapesJS, a WYSIWYG website template creation application. Mavo Create uses drag-and-drop HTML elements with WYSIWYG editing for styling and for adding Mavo capabilities. After creating the template of a Mavo application in Mavo Create, one can download source code and begin using his application. The goal of Mavo Create is to make the creation of Mavo applications accessible to people who do not know HTML or programming.
by Francesca Rose Cicileo.
M. Eng.
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Flaspoehler, Timothy Michael. „FW-CADIS variance reduction in MAVRIC shielding analysis of the VHTR“. Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45743.
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In the following work, the MAVRIC sequence of the Scale6.1 code package was tested for its efficacy in calculating a wide range of shielding parameters with respect to HTGRs. One of the NGNP designs that has gained large support internationally is the VHTR. The development of the Scale6.1 code package at ORNL has been primarily directed towards supporting the current United States' reactor fleet of LWR technology. Since plans have been made to build a prototype VHTR, it is important to verify that the MAVRIC sequence can adequately meet the simulation needs of a different reactor technology. This was accomplished by creating a detailed model of the VHTR power plant; identifying important, relevant radiation indicators; and implementing methods using MAVRIC to simulate those indicators in the VHTR model.
The graphite moderator used in the design shapes a different flux spectrum than water-moderated reactors. The different flux spectrum could lead to new considerations when quantifying shielding characteristics and possibly a different gamma-ray spectrum escaping the core and surrounding components. One key portion of this study was obtaining personnel dose rates in accessible areas within the power plant from both neutron and gamma sources. Additionally, building from professional and regulatory standards a surveillance capsule monitoring program was designed to mimic those used in the nuclear industry. The high temperatures were designed to supply heat for industrial purposes and not just for power production. Since tritium, a heavier radioactive isotope of hydrogen, is produced in the reactor it is important to know the distribution of tritium production and the subsequent diffusion from the core to secondary systems to prevent contamination outside of the nuclear island.
Accurately modeling indicators using MAVRIC is the main goal. However, it is almost equally as important for simulations to be carried out in a timely manner. MAVRIC uses the discrete ordinates method to solve the fixed-source transport equation for both neutron and gamma rays on a crude geometric representation of the detailed model. This deterministic forward solution is used to solve an adjoint equation with the adjoint source specified by the user. The adjoint solution is then used to create an importance map that can weight particles in a stochastic Monte Carlo simulation. The goal of using this hybrid methodology is to provide complete accuracy with high precision while decreasing overall simulation times by orders of magnitude. The MAVRIC sequence provides a platform to quickly alter inputs so that vastly different shielding studies can be simulated using one model with minimal effort by the user. Each separate shielding study required unique strategies while looking at different regions in the VHTR plant. MAVRIC proved to be effective for each case.
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Mavaro, Antonino [Verfasser], Lutz [Akademischer Betreuer] Schmitt und Ulrich [Akademischer Betreuer] Schulte. „Charakterisierung der Nisin Dehydratase NisB / Antonino Mavaro. Gutachter: Lutz Schmitt ; Ulrich Schulte“. Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2011. http://d-nb.info/1017839255/34.
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Fischer, Matthias Gunther. „Genetic and ultrastructural characterization of Cafeteria roenbergensis virus and its virophage Mavirus“. Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/32156.
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Giant viruses infecting unicellular eukaryotes have genomes that overlap in size and coding content with the smallest cellular life forms, thereby blurring the boundary between what is considered living and non-living. Due to their recent discovery, little is known about the biology and host range of giant viruses. In this dissertation, I characterize Cafeteria roenbergensis virus (CroV), the largest marine virus known to date. CroV infects the phagotrophic nanoflagellate C. roenbergensis, a widespread and ecologically important marine zooplankton species. CroV has a 730 kilobase pair DNA genome which is predicted to encode 544 proteins and 22 transfer RNAs. Four genes contained an intein insertion and several genes have not been found before in viruses, including an isoleucyl-tRNA synthetase and a histone acetyltransferase. A 38 kilobase pair region of putative bacterial origin encoded predicted enzymes for the biosynthesis of 3-deoxy-D-manno-octulosonate, a key component of the bacterial lipopolysaccharide layer. Microarray analysis revealed that at least 274 CroV genes were transcribed during infection and that different genes were expressed at early and late stages of viral replication. Promoter sequences specific for each stage were identified. Proteomic analyses showed that the virion is composed of at least 129 CroV-encoded proteins, including a large set of transcription enzymes and several DNA repair proteins. Phylogenetically, CroV was found to belong to the group of nucleocytoplasmic large DNA viruses and was most closely related to Acanthamoeba polyphaga mimivirus, although only a third of the CroV genes had homologues in Mimivirus. I also discovered a smaller virus, the Mavirus virophage, whose replication was dependent on co-infection by CroV and led to decreased CroV production and increased host-cell survival. Mavirus particles co-localized within the CroV virion factory, as shown by transmission electron microscopy of infected cells. Remarkably, the 19 kilobase pair DNA genome of Mavirus was most similar to the Maverick/Polinton eukaryotic DNA transposons, which led to the hypothesis that these transposons have originated from the endogenization of ancient virophages into eukaryotic genomes. This work describes the first giant virus infecting a zooplankton species and demonstrates a clear link between Mavirus and Maverick transposons.
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Calburn, Caroline. „A critical documentation of Mavis Taylor's teaching of improvisation“. Master's thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/13849.
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Bibliography: leaves 186-191.This study documents Mavis Taylor's teaching of Improvisation at the University of Cape Town and provides a critical analysis of the improvisational methods she uses in the training of actors. It places her teaching within the wider field of improvisation understanding the importance of knowledge of 'self for the craft of acting. There is discussion around the role of the imagination and spontaneity in actor-training, and debate is raised regarding the concepts and practice of sensory and emotional memory training. The significance of teaching structure and form as a method for students to manipulate the medium of improvisation is argued, proposing that the creation of alternative meanings and 'realities' is the essence of acting.
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Schaub, Danielle. „Fragmented worlds: narrative strategies in Mavis Gallant's short fiction“. Doctoral thesis, Universite Libre de Bruxelles, 1994. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212667.
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McKillop, Jordan M. „Reducing the activation of the IRIS reactor building using the SCALE/MAVRIC methodology“. Thesis, Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37209.
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The main objective of this research is: (1) to develop a model and perform numerical simulations to evaluate the radiation field and the resulting dose to personnel and activation of materials and structures throughout the IRIS nuclear power plant, and (2) to confirm that the doses are below the regulatory limit, and assess the possibility to reduce the activation of the concrete walls around the reactor vessel to below the free release limit.
IRIS is a new integral pressurized water reactor (PWR) developed by an international team led by Westinghouse with an electrical generation capacity of 335 MWe and passive safety systems. Its design differs from larger loop PWRs in that a single building houses the containment as well as all the associated equipment including the control room that must be staffed continuously. The resulting small footprint has positive safety and economic implications, and the integral layout provides additional shielding and thus the opportunity to significantly reduce the activation, but it also leads to significantly more challenging simulations.
The difficulty in modeling the entire building is the fact that the source is attenuated over 10 orders of magnitude before ever reaching the accessible areas. For an analog Monte Carlo simulation with no acceleration (variance reduction), it would take many processor-years of computation to generate results that are statistically meaningful. Instead, to generate results for this thesis, the Standardized Computer Analyses for Licensing Evaluation (SCALE) with the package Monaco with Automated Variance Reduction using Importance Calculations (MAVRIC) will be used. This package is a hybrid methodology code where the forward and adjoint deterministic calculations provide variance reduction parameters for the Monte Carlo portion to significantly reduce the computational time.
Thus, the first task will be to develop an efficient SCALE/MAVRIC model of the IRIS building. The second task will be to evaluate the dose rate and activation of materials, specifically focusing on activation of concrete walls around the reactor vessel. Finally, results and recommendations will be presented.
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Martens, Debra Kay 1957. „Continuity and discontinuity in the short fiction of Mavis Gallant“. Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65486.
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Oliveira, Daniela Pires. „Nomadismos textuais : Mavis Gallant e a tradução de "Linnet Muir"“. Dissertação, Porto : [Edição de Autor], 2008. http://aleph.letras.up.pt/F?func=find-b&find_code=SYS&request=000189981.
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Neste trabalho de conclusão de mestrado, apresento a tradução para o português do Brasil de quatro contos da série "Linnet Muir", da escritora canadense Mavis Gallant (1922- ), acompanhada de uma dissertação composta por uma selecção de comentários, de uma introdução à autora e a temática dessas histórias e, por fim, de uma reflexão teórica acerca do traduzir. Esta reflexão (que norteará a minha metodologia de tradução dos contos), por sua vez, consiste do articular da abordagem da tradução enquanto um ato de deslocamento ("uma variedade de exílio") com os aspectos estilistícos e temáticos dos contos (aqueles dos espaços, deslocações e do exílio no seu sentido figurado). Em "Linnet Muir" busco, portanto, ferramentas de analogia para verificar possibilidades de transcendência da concepção do exercício tradutório como um mero deslocamento linguístico e semântico, e assim, redimensioná-la, no seu contexto literário, como uma "espécie de nomadismo".
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Oliveira, Daniela Pires. „Nomadismos textuais : Mavis Gallant e a tradução de "Linnet Muir"“. Master's thesis, Porto : [Edição de Autor], 2008. http://hdl.handle.net/10216/8235.
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Neste trabalho de conclusão de mestrado, apresento a tradução para o português do Brasil de quatro contos da série "Linnet Muir", da escritora canadense Mavis Gallant (1922- ), acompanhada de uma dissertação composta por uma selecção de comentários, de uma introdução à autora e a temática dessas histórias e, por fim, de uma reflexão teórica acerca do traduzir. Esta reflexão (que norteará a minha metodologia de tradução dos contos), por sua vez, consiste do articular da abordagem da tradução enquanto um ato de deslocamento ("uma variedade de exílio") com os aspectos estilistícos e temáticos dos contos (aqueles dos espaços, deslocações e do exílio no seu sentido figurado). Em "Linnet Muir" busco, portanto, ferramentas de analogia para verificar possibilidades de transcendência da concepção do exercício tradutório como um mero deslocamento linguístico e semântico, e assim, redimensioná-la, no seu contexto literário, como uma "espécie de nomadismo".
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Dias, Maraina Gomes Pires Fernandes. „Atitudes de enfermeiros de serviços de urgência e emergência psiquiátricas frente ao comportamento violento“. Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/7/7141/tde-06102017-104032/.
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Introdução: A alta prevalência de transtornos mentais na população geral pode refletir no aumento de pessoas nos serviços de emergência de hospitais gerais em sua maioria apresentando queixas de sintomas de um transtorno mental ou de alteração do comportamento. O comportamento violento pode estar associado ao transtorno mental e a agressão por parte desses indivíduos é considerado um problema grave que vem sendo vivenciado nos serviços de saúde, principalmente nas unidades psiquiátricas de curta permanência. Por passarem mais tempo na interação com o paciente, o enfermeiro e a equipe de enfermagem ficam sujeitos à agressão derivada do comportamento violento. A abordagem que a equipe irá adotar depende das suas crenças e atitudes diante das causas desse tipo de comportamento, pois, as mesmas afetarão na qualidade da assistência prestada ao indivíduo e os possíveis danos físicos e psicológicos ao próprio profissional. Objetivo: verificar as atitudes e visões de manejo de enfermeiros de Serviços de atendimento em Urgência e Emergência Psiquiátrica frente ao comportamento violento. Método: Trata-se de um estudo descritivo, exploratório e transversal realizado em 17 serviços públicos referenciados de atendimento psiquiátrico da cidade de São Paulo com uma amostra de 185 enfermeiros que trabalhavam nesses locais. Para coleta de dados foram utilizados a The Management of Aggression and Violence Attitude Scale (MAVAS-BR) e um questionário com dados sociodemográficos. Para análise, os dados foram agrupados em um banco construído no Statistical Package for Social Sciences onde se realizou análise exploratória com frequência absoluta e relativa e medidas de locação (média/mediana) e dispersão (desvio-padrão) para cada item e dos quatro fatores da escala. Para interpretação, quanto menor a média mais a concordância com o fator ou item da escala. Resultados: As atitudes dos enfermeiros estão mais relacionadas aos modelos externo e situacional ou interacional de explicação para o comportamento violento, os participantes mostraram-se mais favoráveis com utilização de métodos de controle para manejo do mesmo. Referente às visões de manejo, concordaram com o uso dos manejos de controle que podem indicar fatores como falta de conhecimento dos enfermeiros em utilizar os manejos não físicos e escassez de recursos humanos nos serviços de saúde. Conclusão: Esse estudo fornece subsídios para elaboração de estratégias educacionais para que o enfermeiro adquira conhecimento e segurança nas intervenções frente a pacientes que apresentem comportamento violento, sugerindo que novas pesquisas sejam realizadas sobre esse fenômeno ainda pouco explorado no contexto brasileiro e latino Americano.Introduction: The high prevalence of mental disorders in the general population may reflect an increase of people in general hospital emergency services, in which mostly of them presenting complaints of symptoms of a mental disorder or behavioral disorder. Violent behavior may be associated with mental disorder and the aggression on the part of these individuals is considered a serious problem that is being experienced in the health services, especially in the short-stay psychiatric units. Because one will spend more time interacting with the patient, the nurse and a nursing staff members are subject to aggression derived from violent behavior. The approach adopted by the members of the nursing staff will depend on their beliefs and attitudes towards the causes of this type of behavior, cause these kind of behavior will affect the assistances quality provided for the individual and may cause physical and psychological damage for the professionals themselves. Objective: to verify the nurses attitudes and views towards violent behaviour in the urgent care and psychiatric. Method: This is a descriptive, exploratory and cross-sectional study carried out in 17 public services referenced in psychiatric care in the city of São Paulo, with a sample of 185 nurses who worked in these places. For the data collection the management attitude scale of aggression and violence (MAVAS-BR) \"and a questionnaire with sociodemographic data were used. For analysis, the data were grouped in a bank built in the Statistical Package for Social Sciences where an exploratory analysis was carried out with absolute and relative frequency and measurements of lease (mean / median) and dispersion (standard deviation / quartiles / minimum / maximum) for each item and each of the four scale factors. For interpretation, the lower the mean, the greater the agreement with the scale factor or item. Results: Nurses\' attitudes are more related to external and situational or interactional models of explanation for violent behavior, the participants were found to be more favorable to the use of control methods to manage it. Regarding management visions, they agreed on the use of control measures that may indicate factors such as lack of knowledge of nurses to use non-physical management and shortage of human resources in health services. Conclusion: This study provides support for the elaboration of educational strategies so that the nurse can acquire knowledge and safety in the interventions against patients who present violent behavior, suggesting that new researches have to be done on this phenomenon still little explored in the Brazilian and Latin American context.
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Saathoff, Friederike. „Characterization of MAVS-dependent antiviral signaling“. Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-178366.
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Hartmangruber, David Patrick. „Using MAVRIC sequence to determine dose rate to accessible areas of the IRIS nuclear power plant“. Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37123.
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The objective of this thesis is to determine and analyze the dose rate to personnel throughout the proposed IRIS nuclear power plant. To accomplish this objective, complex models of the IRIS plant have been devised, advanced transport theory methods employed, and computationally intense simulations performed.
IRIS is an advanced integral, light water reactor with a 335 MWe expected power output (1000 MWth). Due to its integral design, the IRIS pressure vessel has a large downcomer region. The large downcomer and the neutron reflector provide a great deal of additional shielding. This increase in shielding ensures that the IRIS design easily accomplishes the regulatory dose limits for radiation workers. However, The IRIS project set enhanced objectives of further reducing the dose rate to significantly lower levels, comparable or below the limit allowed for general public.
The IRIS nuclear power plant design is very compact and has a rather complex geometric structure. Programs that use conventional methods would take too much time or would be unable to provide an answer for such a challenging deep penetration problem. Therefore, the modeling of the power plant was done using a hybrid methodology for automated variance reduction implemented into the MAVRIC sequence of the SCALE6 program package. The methodology is based on the CADIS and FW-CADIS methods. The CADIS method was developed by J.C. Wagner and A. Haghighat. The FW-CADIS method was developed by J.C. Wagner and D. Peplow. Using these methodologies in the MAVRIC code sequence, this thesis shows the dose rate throughout most of the inhabitable regions of the IRIS nuclear power plant. This thesis will also show the regions that are below the dose rate reduction objective set by the IRIS shielding team.
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Patiño, Chirinos Fernando Luis, Honma Sandra Keiko Yamamoto und Ramos Alfredo Manuel Yi. „Propuesta de un modelo de distribución para la industria de productos de consumo masivo“. Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/601312.
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El objetivo de la presente investigación se centra en “Proponer un modelo de distribución exclusiva para la industria de productos de consumo masivo”, buscando mejorar la distribución con el fin de contar con una cartera más amplia de clientes y siendo sus objetivos específicos incrementar la oferta de productos del fabricante y plantear un esquema de visibilidad para las tiendas detallistas. Dicha propuesta se enfoca en la industria de consumo masivo, específicamente en la categoría de alimentos de consumo humano y empresas que cuenten con un amplio y/o diversificado portafolio de productos, no contemplando la propuesta a empresas que en su propia definición son monopólicas o con tendencias monopólicas, mono productoras y las centradas en la categoría cuidado personal, cuidado del hogar, detergentes, artículos del hogar, cigarrillos y productos para infantes. Para desarrollar la propuesta planteada, el trabajo abarca los siguientes acápites: resumen ejecutivo el cual contempla la amplitud de la propuesta, el índice con el contenido del trabajo, la introducción, un marco teórico enfocado en la distribución, canales de distribución, distribución exclusiva e importancia de la distribución; la problemática actual de la industria del consumo masivo, la propuesta en mención y la validación de la propuesta planteada finalizando con las recomendaciones y conclusiones del caso. Con respecto a la problemática, se han revisado fuentes asociadas a la industria, estudio de una empresa especialistas en investigación de mercado como lo es Arellano Marketing y entrevistas a expertos con mucha experiencia de consumo masivo del lado del fabricante y del distribuidor. La propuesta de tesis se centra en fabricantes de la industria de consumo masivo con las restricciones mencionadas anteriormente. Asimismo la validación del modelo propuesto se halla asociada a una empresa que contiene un portafolio diversificado y con una amplia gama de productos como Molitalia, y en una ciudad específica, Huancayo, en donde se prueba que en dos de sus categorías como lo es la avena y las pastas, mejoran su distribución tanto numérica como ponderada. La herramienta de validación de la propuesta planteada se ha realizado con estudios de una empresa especialista en investigaciones de mercado y auditoría de producto como CCR (Corporation Company of Research), puesto que los principales fabricantes de consumo masivo emplean los servicios de dicha consultora para revisar si el trabajo de sus distribuidores se ve reflejado en los estudios de mercado. Finalmente el presente trabajo concluye con recomendaciones para aquellos fabricantes que deseen aplicar el presente modelo y conclusiones sobre el estudio realizado.Tesis
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Yang, Shaowu [Verfasser]. „Visual SLAM for Autonomous Navigation of MAVs / Shaowu Yang“. Aachen : Shaker, 2016. http://d-nb.info/1084536153/34.
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Geyman, Matthew Kenneth. „Wing/Wall Aerodynamic Interactions in Free Flying, Maneuvering MAVs“. University of Dayton / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1335113432.
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Sexton, Melanie. „The woman's voice: The post-realist fiction of Margaret Atwood, Mavis Gallant and Alice Munro“. Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6822.
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Since Margaret Atwood, Mavis Gallant, and Alice Munro do not frequently employ experimental or overtly metafictional forms, they are often read as realist writers in contradistinction to postmodernists. In fact, the assumptions upon which their work rests have little in common with the assumptions underlying realism, and they are as resoundingly post-realist as their postmodern counterparts. One of the key characteristics of realism is an assumption that language can be a neutral, transparent medium in which life can be rendered without distortion. Yet in the work of Atwood, Munro, and Gallant language is never transparent. Language creates reality, and this creation is always connected to power. The three writers share anxieties about the paradoxical nature of women's relationship to language: women must use language in order to assert their existence in the world, yet language exerts disturbing control, especially over women. This control is insistently depicted as a form of violence. Realism, to use Bakhtin's terms, is essentially monologic--its narrative strategy depends on a single unifying view, which the reader is encouraged to share. These writers, by contrast, parody the monologic view offered by society's master narratives--often depicted as largely male discourses--and expose it as absurdly limited. They explore the heteroglossia of the contemporary world and insistently expose the ways in which discourses exert power, especially over women. Many of their texts are mis-read as closed realist texts when in fact they remain unresolved and dialogic. Realism encourages a view of character as coherent and unitary, capable of undergoing development and reaching maturity. These writers depict the female self as lacking coherence. Often the boundaries between self and others, especially other women, are confused. Emphasis is placed on the importance of how the self is constructed in the eyes of others rather than on any sense of internal development. For these writers the female self is not a stable entity but a construction. Atwood, Gallant, and Munro do not construct fictions that attempt to mirror life--they recognize the power of voice to construct the world. They are therefore not the naive or conservative "realists" they are sometimes read as. In fact, their work, like that of the postmodernists, challenges and deconstructs the assumptions of realism. However, whereas language for the postmodernists has become little more than a play of empty signifiers, for these women writers it is still vitally allied to power.
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Janopaul, Petra E. „Muscled movie mavens, a new need for the female form in "Pumping Iron II", "Terminator 2", and "G.I. Jane"“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ59177.pdf.
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Sowerby, J. Gail Carleton University Dissertation English. „Family walls - a costly inheritance; the implications of social structures in the fiction of Mavis Gallant“. Ottawa, 1987.
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Sundbom, Linda. „Bedömning av fysisk och social lärmiljö på grundskolan : En utprövning av skattningsverktyget MAVIS med lärarskattningar och elevintervjuer“. Thesis, Stockholms universitet, Specialpedagogiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115536.
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Det finns ett positivt samband mellan elevers prestationer, välbefinnande och lärmiljö. Studien i denna uppsats är en utprövning av skattningsverktyget MAVIS, som är skapat för lärare i grundskolans senare år för att utvärdera, analysera och utveckla en lärmiljö. Verktygets innehåll utgår ifrån en teoretisk modell av skolans sociala klimat och definierar tio aspekter av lärmiljö: Stimulans, kompetens, lärande, kontroll, säkerhet, hjälpsamhet, delaktighet, ansvar, inflytande och kreativitet. Studiens syfte är att undersöka användbarhet, identifiera förbättringsmöjligheter, problematiska aspekter och undersöka om verktyget är tillförlitligt, och kan antas mäta kvaliteten på relevanta aspekter av elevers lärmiljö som det avser att göra. Två klasser på två grundskolor var föremål för studien, där sammanlagt sex lärare och sex elever deltog. Lärarna besvarade skattningsverktyget och deltog i ett utvärderingssamtal. Eleverna besvarade skattningsverktyget genom intervju. Resultatet gav att skattningsverktyget upplevdes som användbart och möttes med god acceptans. Två skilda profiler för två olika lärmiljöer kom fram och visade utvecklingsområden samt styrkor inom lärmiljön. Elevers och lärares skattning gav liknande bild av lärmiljön, men lärare skattade lite lägre än eleverna. Förtydliganden av frågors alternativ framkom som förbättringsmöjlighet. Skattningsverktyget verkar kunna användas som diskussionsunderlag för att utveckla lärmiljöer och kan vara en del av specialpedagogens förebyggande arbete.
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Yrwing, Carina. „Bedömning av fysisk och social lärmiljö på grundskolan : En utvärdering av självskattningsverktyget MAVIS med lärarskattningar och klassrumsobservationer“. Thesis, Stockholms universitet, Specialpedagogiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-115539.
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Skolor bör arbeta och verka för inkludering och inför detta arbete menas att ett gott fysiskt och socialt klimat är en förutsättning. Socialt klimat omfattar relationer och samspel vilka anses inverka på välmående, beteende, prestationer och som skydd mot skolmisslyckanden för elever i behov av särskilt stöd. Denna pilotstudie är ett första valideringsförsök av självskattningsverktyget Målsättningar och värderingar i skolan, MAVIS, en enkät för lärare som innehåller 50 frågor föredelade på 10 områden: Kreativitet, Stimulans, Lärande, Kompetens, Säkerhet, Kontroll, Hjälpsamhet, Delaktighet, Ansvar och Inflytande. Verktyget är utvecklat från en teoretisk modell av det sociala klimatet som definierar dess egenskaper utifrån universella mänskliga värderingar och behov. Syftet med studien är att undersöka hur detta självskattningsverktyg för lärare verkar fungera för att få en uppfattning om det sociala klimatet i några klasser och om det kan antas vara användbart samt ha en acceptabel tillförlitlighet som instrument. Syftet är även att identifiera förbättringsmöjligheter vid användandet av skattningsinstrumentet. Studien är förlagd på två grundskolor och deltagare är två klasser ur årskurs åtta och sex lärare. Metodansatsen är både kvantitativ och kvalitativ och omfattas av lärarskattningar, skattningar utifrån observationer samt samtal med deltagande lärare. Resultatet pekar på att skattningar kan visa på mönster och ge indikationer på en klass fysiska och sociala klimat. Skattningsverktyget öppnar upp för diskussioner utifrån skolans/elevgruppens styrkor och utvecklingsområden vilka kan användas av specialpedagog, lärare och skolledningen i verksamhetens förändringsarbete och utveckling av det fysiska och sociala klimatet.
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Ricardo, António Manuel Brigas. „Modelo geométrico de correcção da medição de fluxo sanguíneo na angiografia PC por RM em MAV’s cerebrais“. Master's thesis, FCT - UNL, 2010. http://hdl.handle.net/10362/3614.
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Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para a obtenção do grau de Mestre em Engenharia BiomédicaAs malformações arteriovenosas (MAV’s) cerebrais são conjuntos anormais de vasos sanguíneos, onde o sangue pode passar directamente das artérias nutrientes para as veias de drenagem sem passar pelos comuns capilares. Esta é uma das lesões no cérebro reconhecidas como origem de hemorragias e causa de morbilidade. Uma das técnicas de tratamento das MAV’s é a embolização, que consiste na obstrução de alguns, ou todos os vasos que alimentam as MAV’s, pela colocação de uma gota de cola intravascular. Para determinar quais dos vasos nutrientes devem ser embolizados pode-se medir a pressão sanguínea através de cateteres, de modo a ter uma ideia do fluxo sanguíneo local. No entanto, com a sequência Phase Contrast (PC) de Angiografia por Ressonância Magnética (ARM), poderá ser possível utilizar uma forma menos invasiva de medir o fluxo e a velocidade do fluído sanguíneo das várias artérias e saber assim quais destes vasos das MAV’s apresentam maiores riscos de hemorragia. Na técnica corrente de PC, a velocidade medida depende do ângulo que o vaso faz com o plano de aquisição da imagem. Onde o valor correcto é dado com um plano definido perpendicularmente ao vaso de estudo. Com esta sequência, nos casos em que se pretende medir mais do que um vaso, como nas artérias nutrientes das MAV’s cerebrais, o procedimento pode torna-se muito moroso. Contudo, poderá ser possível, numa única aquisição, medir as várias velocidades se forem conhecidos os ângulos correctos de todos os vasos das MAV’s relativamente ao plano de aquisição. Para o efeito, deduziu-se uma equação geométrica que, baseada nos ângulos medidos em duas imagens, coronal e sagital, reconstruídas de uma sequência 3D vascular, nos permite deduzir o ângulo correcto que cada vaso de interesse faz com o plano de aquisição PC e assim poder corrigir o valor do fluxo medido pela sequência PC para o seu valor real. Esta equação foi testada através de várias medições do fluxo na artéria basilar de um mesmo indivíduo, na qual é possível determinar facilmente a sua orientação e o seu fluxo, fazendo variar a inclinação dos vários planos de aquisição. Os resultados obtidos produziram velocidades e fluxos consistentes que demonstraram a validade da equação, mostrando assim que pode ser possível aplicar esta sequência na medição dos fluxos nas várias artérias nutrientes de uma MAV numa única sequência de aquisição.
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Nakhaei, Peyman. „Regulation of the RIG-I/MAVS antiviral and apoptotic signaling pathways“. Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96777.
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The success of the antiviral response by the host relies on several families of pathogen recognition receptors (PRRs) and sensors that recognize structures conserved among microbial species, culminating in the production of cytokines and chemokines to combat viral infection and signal the formation of an effective adaptive response. At the cellular level, the production of type I interferon (IFN) is regulated at multiple levels. The synergistic action of activated transcription factors such as AP-1, NF-kB and IRFs on the promoters of type I IFN genes triggers the immediate early IFN response, that is further amplified by the JAK-STAT signaling pathway. Thus far, three main families of PRRs have been identified: The transmemebrane Toll-like receptors (TLRs), the cytosolic Nod-like receptors (NLRs) and the RIG-I-like receptors (RLRs). In addition, cytosolic sensors of double-stranded dsDNA have been shown to play an important role in triggering type I IFN and caspase-1 inflammmasome pathways. Throughout the pathogen-host co-evolution, viruses have evolved numerous mechanisms to subvert the antiviral response, as well as prevent host cell apoptosis to promote virus propagation. As a consequence, the development of effective antiviral strategies requires in depth knowledge of IFN and apoptotic signaling pathways. Thus, our first objective was to identify regulators of RNA virus signaling pathways. In our first study, we establish Triad3A, a previously described negative regulator of TLR and TNFR, as an important molecule modulating the RIG-I/MAVS signaling pathway by proteasomal-mediated degradation of the adaptor molecule TRAF3. The second objective of our study was to provide a link between host cell-mediated apoptosis and host cell-mediated antiviral response. The results from our second study demonstrate that the establishment of a complete antiviral response requires pro-apoptotic proteins Bax and Bak-induced cell death in response to RNA virus infection. Therefore, the final aim of this thesis project was to identify apoptotic regulators of the RIG-I signaling pathway. Our third study demonstrates that the noncanonical kinases TBK1/IKKepsilon directly phosphorylate and regulate XIAP protein levels, which in turn regulates IRF-3-Bax-mediated apoptosis. Overall, these studies highlight important regulatory mechanisms and links between apoptotic signaling and the antiviral response that may provide a future avenue for more efficacious vaccines and therapies.Le succès de la réponse antivirale de l'hôte repose sur plusieurs familles de récepteurs qui reconnaissent des structures conservées d'agents pathogènes (PRRs) et qui abouti à la production de cytokines et de chimiokines pour lutter contre l'infection virale et induire une réponse antivirale acquise. Au niveau cellulaire, la production d'interféron (IFN) de type I est régulé à plusieurs niveaux. L'action synergique des facteurs de transcription activés tels que AP-1, NF-kB et IRF sur les promoteurs des gènes de l'IFN de type I déclenche une réponse immédiate qui est amplifiée par la voie de signalisation JAK-STAT. Jusqu'à présent, trois grandes familles de récepteurs d'agents pathogènes ont été identifiés: les récepteurs transmembranaire Toll-like (TLR), les récepteurs cytosolique Nod-like (NLR) et les récepteurs cystosolique RIG-I-like (RLR). De plus, il a été montré que des récepteurs cytosoliques reconaissant le double brin d'ADN jouent un rôle important dans le déclenchement de la réponse IFN de type I et les voies de signalisation inflammatoire reliées à la caspase-1. Au cours de l'évolution, les virus ont developpé de nombreux mécanismes pour échapper à la réponse antivirale et bloquer l'apoptose de la cellule hôte pour ainsi promouvoir la propagation du virus. En conséquence, le développement de stratégies antivirales efficaces exige une connaissance approfondie des voies de signalisation de l'IFN et de l'apoptose. Ainsi, notre premier objectif était d'identifier des régulateurs des voies de signalisation activées par les virus à ARN. Dans notre première étude, nous établissons que Triad3A, un régulateur negatif de la signalisation des TLR et TNFR décrit précédement, module la voie de signalisation RIG-I/MAVS par la dégradation protéomique de la molecule adapteur TRAF3. Le deuxième objectif de notre étude était d'établir un lien entre l'apoptose cellulaire et la réponse antivirale. Les résultats de notre deuxième étude montrent qu'une réponse antivirale complète dépend de la mort cellulaire induite par les protéines pro-apoptotiques Bax et Bak suite à une infection par un virus à ARN. Par conséquent, l'objectif final de ce projet de thèse était d'identifier des protéines régulant l'apoptose induite par la voie de signalisation RIG-I. Notre troisième étude montre que les kinases non-canoniques TBK1/IKKepsilon phosphorylent directement et régulent le niveau de la protéine XIAP, qui à son tour régule l'apoptose causée par IRF-3-Bax. Globalement, ces études mettent en lumière d'importants mécanismes de régulation et des liens entre la signalisation apoptotique et la réponse antivirale qui pourrait permettre le dévelopment de vaccins et de thérapies plus efficaces.
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Saathoff, Friederike [Verfasser], und Carole [Akademischer Betreuer] Bourquin. „Characterization of MAVS-dependent antiviral signaling / Friederike Saathoff. Betreuer: Carole Bourquin“. München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1066206473/34.
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Stefl, Samantha Jean. „The Role of Mixed Lineage Kinase 3 in MAVS- Dependent Signaling“. University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1438955382.
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Sturgess, Charlotte Jane. „A politics of location : subjectivity and origins in the work of Mavis Gallant, Alice Munro and Margaret Atwood“. Thesis, Queen Mary, University of London, 1993. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1603.
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This thesis attempts to discover the links between concepts of identity and origins, and Canadian women's writing. The work of three English-speaking Canadian women writers, Mavis Gallant, Margaret Atwood and Alice Munro, will be examined in order to discover the ways in which their writings problematize feminine subjecthood, and in doing so shed light on a specifically Canadian 'discourse' of identity. I posit thereby, that perceiving the absences and silences structuring their modes of representation is a (symbolic) means of perceiving Canada as a dualistic, fractured, and contradictory unity. This implies a dialogue between text and context: a reading of one through the other. The three writers in question draw on diverse, and often opposing, centres of cultural and personal consciousness. I shall attempt to demonstrate however, that the problematical concept of origins and its relation to location and to feminine self-hood defines all three. To do so I have chosen those texts, whether novel or short story, which to my mind best articulate the social, cultural and symbolic discourses informing the definition 'English-speaking Canadian Women's writing'. Other works not included would undoubtedly have proved of interest, but the type of 'close reading' which such themes required entailed an automatic limitation on the range of fiction under scrutiny
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Yang, Shaowu [Verfasser], und Andreas [Akademischer Betreuer] Zell. „Visual SLAM for Autonomous Navigation of MAVs / Shaowu Yang ; Betreuer: Andreas Zell“. Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1162971614/34.
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Wood, Kieran Thomas. „Control strategy for MAVs with delayed, low rate monocular visual SLAM feedback“. Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687191.
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The full autonomous control of a rotary-wing Micro Aerial Vehicle (MAV) relies on measurement inputs from sensors to allow the vehicle to maintain a constant position in a 3D environment. Monocular Visual SLAM (VSLAM) is a particularly efficient sensing method in terms of payload cost. A single camera can be used to provide a full 6-DOF pose measurement, however, this is at the cost of increased communication bandwidth and computational requirements, often resulting in low-rate and delayed feedback measurements. This thesis presents an investigation into the use of VSLAM feedback to stabilise the full 3D position of a MAV. To reach this goal, experimental work is conducted using small rotary-wing platforms in indoor environments. Platforms include the static 3-DOF Quanser and the 6-DOF AR.Drone2.0 quadrotor. Theoretical dynamic models are developed and simplified into decoupled linear sub-systems. The sensing properties of VSLAM are also experimentally identified for both static and dynamic flight scenarios. The control challenge of low-rate delayed measurements is overcome by applying discrete-time LQG control design methods. A discretisation method is detailed which can represent arbitrary delays in a discrete state-space form whilst preserving the dynamic behaviour. A method of tuning the LQG to preserve the reference tracking response is presented, making use of the discrete delayed model structure. Initially the presented control design is experimentally applied to SISO systems to assess the performance, making use of high accuracy external tracking systems. The result is then extended to the full 6-DOF helicopter where free flight is demonstrated, using VSLAM as the only pose measurement, with no additional sensors required to initialise VSLAM.
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Dickson, Rothwell Carmel. „Andrew Allan, Nathan Cohen, and Mavor Moore: Cultural nationalism and the growth of English-Canadian drama, 1945 to 1960“. Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/6914.
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"Andrew Allan, Nathan Cohen, and Mavor Moore: Cultural Nationalism and the Growth of Canadian Drama 1945-1960" is concerned with the texture and substance of English-Canada's cultural life in the decade and a half following World War II. This thesis represents a case study in English-Canadian cultural nationalism by focussing on the views of three cultural nationalists who believed that the creation of a national theatre could establish a unique Canadian identity and national unity. Essentially, the thesis argues that the early enthusiasm of the period for the potential of Canadian drama, and high culture in general, was thwarted by public apathy, an inferiority complex, the failure of the government to act on the recommendations of the Massey Report, and the omnipresence of television which paved the way for the conquest of mass culture and technology. By simply articulating their concerns about Canadian culture which were validated by the Massey Commission, cultural nationalists demonstrated that a distinct Canadian culture did exist in spite of the growing influence of the United States. (Abstract shortened by UMI.)
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Kgadima, Mavis Solani. „The role of the school management team in the implementation of an assessment policy in primary schools / Mavis Solani Kgadima“. Thesis, North-West University, 2006. http://hdl.handle.net/10394/1458.
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Glatzer, Mordechai Isaac ben Abba Mari. „ʻIṭur sofrim (Sefer ha-ʻIṭur) le-Rav Yitsḥaḳ ben Rav Aba Mari : pirḳe mavo /“. Yerushalayim : ha-Universiṭah ha-ʻIvrit bi-Yerushalayim, ha-Faḳulṭah le-madaʻe ha-ruaḥ, 1985. http://books.google.com/books?id=TKTjAAAAMAAJ.
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Thesis (Ph. D.)--ha-Universiṭah ha-ʻIvrit bi-Yerushalayim, Jerusalem, 1983."Ittur sofrim (Sefer ha-ittur) of R. Isaac b. Abba Mari"--Added t.p. Includes bibliographical references (vol. 1, p. 164-167) and index.
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Sanchez, Daniel M. Eng Massachusetts Institute of Technology. „Adding sorting and grouping to the Mavo framework for end user web application authoring“. Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119601.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.Cataloged from PDF version of thesis.
Includes bibliographical references (page 53).
Sorting and grouping in Mavo gives developers further control as to how the data shown on their webpage will be displayed. Given a collection of elements with the same underlying data schema, users can choose a property of these elements whose value should be used as a sorting criterion for what order the elements appear in. Expanding on this, Mavo users can also view a collection of data in groups, where group headings appear above a subset of the items denoting a shared characteristic of the items. With this additional functionality, Mavo developers can now author more powerful web applications that react dynamically to user input to display their data in a more meaningful way. All this new functionality comes with the existing ease-of-use of Mavo, requiring only an HTML attribute to specify how the data should be displayed, and how the view should update should changes in the data occur.
by Daniel Sanchez.
M. Eng.
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Castanier, Céline. „Étude de la régulation de la protéine mitochondriale MAVS au cours de l’immunité innée antivirale“. Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T046.
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L’immunité innée représente la première ligne de défense d’un organisme face à une infection virale, en engendrant une réponse rapide capable de restreindre la menace microbienne. Dans la cellule, les récepteurs Toll-likes (TLRs) et les hélicases cytosoliques RIG-I like (RLRs) représentent les deux systèmes majeurs de reconnaissance des virus. Les acides nucléiques viraux sont notamment reconnus les hélicases cytosoliques RIG-I et MDA5. Ces deux protéines possèdent deux domaines CARD impliqués dans le recrutement de la protéine adaptatrice MAVS, capable d’induire l’activation des promoteurs interférons (IFNs) de type I et de NF-B pour la mise en place d’une réponse antivirale. De façon surprenante, MAVS est localisée au niveau de la mitochondrie et a besoin de cette association au compartiment mitochondrial pour exercer sa fonction. Bien que de nombreuses études aient montré le rôle crucial de la protéine mitochondriale MAVS dans la signalisation antivirale des RLRs, sa régulation est encore mal connue à ce jour. Ce travail de doctorat a permis de mettre en évidence que la dégradation de MAVS suite à une infection virale est nécessaire à la transduction du signal antiviral. Nous avons ainsi déterminé que l’E3 ubiquitine ligase TRIM25 induit l’ubiquitination puis la dégradation de MAVS quelques heures après une infection virale. De plus, nous avons montré que l’activation du signalosome aboutissant à la production des IFNs de type I et dépendant de MAVS n’a lieu que suite à sa translocation de la mitochondrie vers le cytosol permise par la dégradation de MAVS. Enfin, nous avons mis en évidence le rôle essentiel de l’élongation du réseau mitochondrial suite à une infection virale pour la transduction du signal dépendant de MAVSInnate Immunity acts as the first line of the host defense against viral infection, providing a rapid response to restrict the microbial threats. Toll-like receptors (TLRs) and cytosolic RIG-I-like helicases (RLRs) are the two major receptor systems for detecting virus. Viral nucleic acids are recognised by the helicases RIG-I and MDA5. These receptors contain two CARD domains involve in the recruitment of the mitochondrial antiviral signaling adaptor MAVS whose activation triggers a rapid production of type 1 interferons (IFNs) and of pro-inflammatory cytokines. Interestingly, it has been reported that MAVS must be localized to mitochondria to exert its function. While MAVS is essential for this signaling, its function and regulation remain unclear. In this work, we report that RLR activation triggers MAVS ubiquitination by the E3 ubiquitin ligase TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling. MAVS appears to function as a recruitment platform to first assemble a signaling complex, then the proteasome-mediated MAVS degradation is required to unleash into the cytosol this signaling complex allowing the signalosome activation and ensuing type I IFNs production. Futhermore, we reported that mitochondrial dynamics regulate MAVS-mediated signaling after viral infection
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Ermler, Megan Elizabeth. „MAVS is Essential for Regulation of Innate Immune Signaling during Rift Valley Fever Virus Infection“. Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1378752537.
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Bredwad, Linnéa, und Carina Wikman. „Det sociala klimatet i lärandemiljöer : En pilotstudie kring självskattningsverktyget MAVIS möjligheter att vägleda och stödja förändringar i två lärargrupper i en grundskola“. Thesis, Stockholms universitet, Specialpedagogiska institutionen, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-144948.
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Läroplan, styr- och policydokument gynnar ett relationellt förhållningssätt och fastställer att skolan ska arbeta för inkludering. Forskning visar att det finns samband mellan elevers välbefinnande och studieresultat och skolans/gruppens lärandemiljö. Trots detta är området nedprioriterat vilket gör det angeläget att studera. Studien som kan ses som en explorativ pilotstudie undersöker hur lärare i två lärargrupper bedömer, genomför och arbetar med lärandemiljön utifrån en självskattning. Syftet är att undersöka om modellen av det sociala klimatet och självskattningsverktyget MAVIS kan användas inte enbart för att beskriva, utan också för att vägleda och stödja förändringar av det sociala klimatet och lärandemiljön i grundskoleklasser. Verktyget är utvecklat utifrån en modell av det sociala klimatet som även är uppsatsens teoretiska utgångspunkt. Modellen stödjer analys, utvärdering och utveckling av värderingar och målsättningar inom skolans organisation. Tio lärare, varav sex undervisande i en årskurs 7 och fyra i en årskurs 8 har deltagit i studien. ”Mixed methods” har använts vilket innebär en metodansats som både är kvalitativ och kvantitativ. Datainsamlingen har genomförts genom att informanterna har ifyllt enkäten MAVIS, diskuterat och samtalat under inspelning samt fyllt i en frågeenkät med öppna frågor. Resultatet visar att modellen för det sociala klimatet och skattningsverktyget kan användas för att upptäcka utvecklingsområden i lärandemiljön. Det kan stödja lärarna att fokusera ett område och främja reflektion, diskussion och samarbete. Chanserna till framgångsfullt förändringsarbete ökar genom ett bottom-up-perspektiv där praktikerna själva får definiera behoven och insatserna och eftersom MAVIS styr in arbetet mot miljön fokuseras gruppen istället för individen, något som kan leda till ökad inkludering.
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David, Dylan Naitraj. „Inflammation-Induced HSPC Dysfunction: Towards a Better Understanding of the Role of MAVS, ASC, and Caspase-1 in HSPC Dysfunction and Bone Marrow Failure“. University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1626356668978688.
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Ahmadi, Pour Malek. „Role of the mitotic Polo-like kinase PLK1 in the control of the interferon induction pathway mediated by the mitichondria-bound MAVS protein and the IKKε protein kinase“. Paris 6, 2009. http://www.theses.fr/2009PA066318.
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A la suite d’infections virales ou de conditions de stress, les cellules montent une réponse immune innée qui conduit à la production d’interféron et de cytokines pro-inflammatoires. MAVS, une protéine adaptatrice liée aux mitochondries et les IRF3/7 kinases TBK1 et IKKε, situées en aval, sont d’importants effecteurs de cette réponse. Une particularité de IKKε, par rapport à TBK1, est de s’associer avec MAVS à la mitochondrie au cours de leur activation. Une recherche de partenaires pour MAVS et IKKε par crible double hybride en levure a révélé la polo-like kinase PLK1 mitotique comme leur unique partenaire commun. L’objectif de ce travail a été de caractériser ces deux associations et de définir leur importance dans la réponse immune innée. Dans une première partie, nous montrons que PLK1 s’associe avec MAVS via son domaine Polo-box (PBD) sur un motif STP où le résidu T central est phosphorylé, une caractéristique commune à de nombreuses cibles de PLK1. PBD s’associe aussi à la partie C terminale de MAVS mais de façon indépendente de phosphorylation. Ceci conduit à l’inhibition de l’association de MAVS avec son partenaire aval TRAF3 et à l’inhbition de la capacité de MAVS à activer les voies NF-B et IRF3 ainsi que l'induction de l’IFN-. Dans une deuxième partie, nous montrons que PLK1-PBD interagit avec le domaine catalytique de IKKε, indépendamment de son site de liaison aux phosphopeptides. Cette association dépend de l’activité catalytique de IKKε mais non de celle de PLK1. PLK1 inhibe la capacité de IKKε à induire l’IFN- et à activer les voies IRF3 et NF-B. Au contraire de la situation avec MAVS, cette inhibition n’est pas médiée par PLK1-PBD mais implique l’activité catalytique de PLK1. L’activité de IKKε peut être restaurée par la molécule BI2536, un compétiteur de la liaison de l’ATP au domaine catalytique de PLK1. Dans l’ensemble, nous démontrons un nouveau mode de régulation de la réponse immune innée par la protéine kinase mitotique PLK1. Nos données peuvent conduire au développement d’inhibiteurs capables d’empêcher l’interaction PLK1/MAVS et/ou PLK1/IKKε afin de soutenir et/ou de moduler la réponse immune innée.
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Linkugel, Thomas [Verfasser], und Andreas [Akademischer Betreuer] Schilling. „Ein modellbasiertes Verfahren zur Entwicklung von VTOL-MAVs mittels einer 3D-Echtzeit-Simulation / Thomas Linkugel ; Betreuer: Andreas Schilling“. Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1168728924/34.
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Miller, Matthew Michael. „Modeling, Designing, Building, and Testing a Microtubular Fuel Cell Stack Power Supply System for Micro Air Vehicle (MAVs)“. Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/76880.
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Research and prototyping of a fuel cell stack system for micro aerial vehicles (MAVs) was conducted by Virginia Tech in collaboration with Luna Innovations, Inc, in an effort to replace the lithium battery technology currently powering these devices. Investigation of planar proton exchange membrane (PEM) and direct methanol (DM) fuel cells has shown that these sources of power are viable alternatives to batteries for electronics, computers, and automobiles. However, recent investigation about the use of microtubular fuel cells (MTFCs) suggests that, due to their geometry and active surface areas, they may be more effective as a power source where size is an issue. This research focuses on hydrogen MTFCs and how their size and construction within a stack affects the power output supplied to a MAV, a small unmanned aircraft used by the military for reconnaissance and other purposes. In order to conduct this research effectively, a prototype of a fuel cell stack was constructed given the best cell characteristics investigated, and the overall power generation system to be implemented within the MAV was modeled using a computer simulation program.
The results from computer modeling indicate that the MTFC stack system and its balance of system components can eliminate the need for any batteries in the MAV while effectively supplying the power necessary for its operation. The results from the model indicate that a hydrogen storage tank, given that it uses sodium borohydride (NaBH4), can fit inside the fuselage volume of the baseline MAV considered. Results from the computer model also indicate that between 30 and 60 MTFCs are needed to power a MAV for a mission time of one hour to ninety minutes, depending on the operating conditions. In addition, the testing conducted on the MTFCs for the stack prototype has shown power densities of 1.0, an improvement of three orders of magnitude compared to the initial MTFCs fabricated for this project. Thanks to the results of MTFC testing paired with computer modeling and prototype fabrication, a MTFC stack system may be possible for implementation within an MAV in the foreseeable future.Master of Science
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He, Lichun [Verfasser], und Christiane [Akademischer Betreuer] Ritter. „Structural basis for signaling in innate immunity via autocatalytical changes of MAVS by NMR / Lichun He ; Betreuer: Christiane Ritter“. Braunschweig : Technische Universität Braunschweig, 2014. http://d-nb.info/1175820369/34.
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Laak, Claudia van. „Zellautonome angeborene Immunantwort in humanen Endothelzellen auf die Infektion mit Chlamydophila pneumoniae“. Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16948.
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Wirtszellen verfügen über bisher unzureichend verstandene zellautonome Immunmechanismen zur Abwehr von intrazellulären Bakterien. In dieser Arbeit wurden zwei Abwehrmechanismen charakterisiert, die in Endothelzellen und Makrophagen Infektionen durch C. pneumoniae bekämpfen. Es konnte gezeigt werden, dass C. pneumoniae über einen MAVS-abhängigen Signalweg in humanen Endothelzellen erkannt wird. Diese Erkennung aktiviert die Transkriptionsfaktoren IRF3 und IRF7 und nachfolgend eine IRF3/7-abhängige Typ I-IFN-Produktion. Typ I-IFN bewirken auto- und parakrin eine Kontrolle der intrazellulären Infektion mit C. pneumoniae. Zum anderen wurde gezeigt, dass das mitochondriale Molekül NLRX1 eine zellautonome Abwehr gegen C. pneumoniae in Endothelzellen und in Makrophagen vermittelt. Diese NLRX1-abhängige intrazelluläre Abwehr ist unabhängig von verschiedenen, bisher mit NLRX1 in Verbindung gebrachten Signalwegen. Die Ergebnisse zeigen somit zum ersten Mal, dass NLRX1 eine zellautonome Abwehr gegen intrazelluläre Bakterien vermittelt. Daraus gewonnene Erkenntnisse sowie die Ergebnisse zukünftiger Arbeiten zur Klärung der NLRX1- und MAVS-aktivierenden chlamydialen Moleküle und den durch Typ-I-IFN-abhängigen intrazellulären Abwehrmechanismen könnten bei der Erforschung neuartiger antibakterieller Therapien hilfreich sein. Diese ist angesichts der weltweiten signifikanten Zunahme von mehrfach-resistenten Infektionserregern, unbedingt notwendig.The cell autonomous defense mechanisms against intracellular bacteria in host cells are so far insufficiently understood. In the present work two defense mechanisms involved in the elimination of C. pneumoniae in endothelial cells and in macrophages were characterized. It could be shown that C. pneumoniae is recognized by a MAVS-dependent signaling pathway in human endothelial cells. This recognition activates the transcription factors IRF3 and IRF7 and subsequently an IRF3/7-dependent type I-IFN production. Type-I-IFNs induce an auto- and paracrine control mechanism against the intracellular infection with C. pneumoniae. Additionally it could be shown for the first time that the mitochondrial NLR molecule NLRX1 mediates a cell autonomous defense mechanism against C. pneumoniae and most likely other intracellular bacteria in human endothelial cells and murine macrophages. This NLRX1-dependent intracellular defense mechanism is independent of the different mechanisms which were so far linked to NLRX1. The outcome of this work and future studies to identify chlamydial molecules responsible for the activation of the MAVS- and NLRX1-dependent signaling pathways as well as the effector mechanisms responsible for Type-I-IFN-dependent control of intracellular chlamydial replication could be very helpful in the development of novel antibacterial therapies.
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Brubaker, Sky William. „Identification of an Antiviral Signaling Variant Demonstrates Immune Regulation Through Alternative Translation“. Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070055.
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Innate immune signaling pathways initiate host defenses against viral pathogens. Receptors specific for viral nucleic acids activate these pathways culminating in cell-to-cell communication and/or cell death. In mammals, this cell- to-cell communication is achieved through the production of interferons and pro- inflammatory cytokines, which activate antiviral defenses in uninfected neighboring cells and instruct adaptive immune responses. The production of these signaling molecules is essential for the defense against viral infection, but must also be tightly regulated to prevent unnecessary inflammation. As an antiviral defense, cell death is also an effective mechanism to limit viral replication and spread but comes with the cost of tissue damage and inflammation. Therefore, regulating these antiviral responses is critical for controlling the spread of infection as well as preventing unnecessary pathologies related to excessive signaling. Hundreds of genes are involved in controlling these immune responses and a wide variety of mechanisms are utilized to regulate them. One mechanism to regulate gene function is the generation of protein variants through alternative translation. While polycistronic transcripts are a common feature of bacterial and viral gene expression, the process of alternative translation as a means to regulate gene function is not a feature generally attributed to mammalian mRNA. This dissertation describes a novel regulator of antiviral signaling that is generated through alternative translation. Expression of the transcript encoding the antiviral adaptor protein, MAVS, results in the production of two proteins: the full-length MAVS adaptor and a truncated variant, miniMAVS. Production of these proteins is in part regulated by cis-acting elements that control translation initiation. Production of miniMAVS regulates antiviral signaling by limiting interferon production induced by full-length MAVS, whereas both MAVS variants positively regulate cell death. To identify other examples of alternative translation in mammalian cells a genome-wide ribosomal profiling technique was used to generate a candidate list of antiviral truncation variants. This dissertation therefore demonstrates that protein variants generated through alternative translation of polycistronic mRNAs can be an effective mechanism for immune regulation and may be more common than previously understood.
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Sparks, Jeremy Ryan. „EXPERIMENTAL FLOW VISUALIZATION FOR CORRUGATED AIRFOILS AT LOW REYNOLDS NUMBER INCLUDING DEVELOPMENT OF A PITCH AND PLUNGE FIXTURE“. UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_theses/141.
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Micro Air Vehicles (MAV’s) have small size and extreme maneuverability which makes them ideal for surveillance. Propulsion mechanisms include propellers, rotors, and flapping airfoils. Flapping motions, along with biologically-inspired wing profiles, are of interest due to their use of natural physics. Corrugated airfoil structures appears to have poor aerodynamic performance at higher Reynolds numbers, but serve well at Re<10,000. Understanding flow structures around corrugated profiles and comparing them to a standard airfoil will aid in understanding how these corrugated profiles perform well and have been adopted by some of nature’s most acrobatic flyers. Motivation for this investigation is to compare static flow visualizations of corrugated profiles to a standard National Advisory Committee for Aeronautics (NACA) airfoil from low to high angles of attack and further observe flow structure development of a pitching and plunging flat plate at a Re<10,000 and a Strouhal number relevant to natural fliers. The static visualization was conducted at Re=1,000 with a NACA 0012 airfoil and two corrugated models. The Pitch and Plunge Fixture (PPF) developed was constructed by simplifying flapping wings as a two degree of freedom motion in plunge (translation) and pitch (rotation). Results obtained from the PPF were compared with a numerical simulation.
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Melnychuk, Oleksandr. „Ukraine Financial Markets - The Analysis of Financial Frauds“. Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-161874.
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Ukraine is quite new country, which faces early stages of its development. The financial market of the country has passed through different and challenging times for these 20 years and still has to choose several essential factors for the further development. The existence of financial frauds in Ukraine could be explained by lack of knowledge and information in the country as well as low level of trust to the government. The case of JSC "MMM" and Mr. Mavrodi is the best well-known example of Ponzi scheme in Ukraine and all post-Soviet countries, which gives the possibility to analyze the main features of its consequences.
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Sistigu, Antonella. „Inflammatory and immune reactions in response to chemotherapy-induced cell death. Viral mimicry chemotherapy : ds RNA sensors and IFNAR signalling indispensable for immunogenic tumor cell death“. Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T052.
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Certains motifs moléculaires associés à la mort cellulaire semblent identifier les cancers prompts à répondre à une thérapie cytotoxique. Ceci en élaborant une réponse anti-tumorale basées sur une réponse T protectrice. Mon travail de thèse montre que le traitement par chimiothérapie immunogène active des voies moléculaires mimant une infection virale. Ceci conduit au niveau des cellules tumorales à une signalisation autocrine via l’IFNαβ / IFNAR1/2, initiée par la reconnaissance d’ARN double brin (dsRNA) endogène par les Récepteurs endosomaux de Reconnaissance des Motifs (PRRs). De façon plus détaillée, nous montrons que les axes TLR3/TRIF (senseurs endosomaux de dsRNA) et IFNAR1/2 (Récepteurs de l’IFN de Type I) doivent signaliser au niveau de la cellule tumorale pour que la chimiothérapie puisse aboutir à l’induction de l’axe CXCL10/CXCR3 et éliciter une réponse efficace in vivo. L’analyse du profil ARN de cellules tumorales Tlr3+/+ (mais pas Tlr3-/-) exposées aux anthracyclines a révélé une forte empreinte virale/IFN, indispensable à l’efficacité/activité anti-tumorale. Le fait d’affecter les axes TLR3 ou IFNAR1/2 au niveau tumorale soit à l’aide d’anticorps neutralisants, soit à l’aide de modèles KO abroge le relarguage de CXCL10 induit par la chimiothérapie, et ainsi la capacité à contrôler la pousse tumorale à moins que de l’IFNαβ ou du CXCL10 exogène soit co-administré aux anthracyclines. De plus la chimiorésistance des tumeurs traitées par des molécules n’induisant pas de signature virale peux être réversée par de l’IFN de Type I exogène. Enfin, la détection d’une signature IFN au niveau de biospies de cancers du sein humains permet de prédire la bonne réponse au traitement adjuvant par anthracyclines. D’un point de vue de l’évolution, alors que les tumeurs (comme les virus) ont élaboré des mécanismes pour échapper aux réponses IFN, la signature virale induite par la chimiothérapie devrait contribuer à contrecarrer cette immunoéditionDistinct cell death-associated molecular patterns might define cancers proned to respond to a cytotoxic therapy by mounting a protective T cell-based anticancer immunity. My PhD Thesis work shows that immunogenic chemotherapy phenocopies viral infection leading to autocrine IFNαβ/IFNAR1/2 signalling in tumor cells initiated by recognition of self dsRNA by endosomal pattern recognition receptors (PRRs). In detail, TLR3/TRIF (endosomal dsRNA sensors) and IFNAR1/2 (Type I IFN receptors) must signal within the tumor cells so that chemotherapy can induce downstream CXCL10/CXCR3 axis and elicit therapeutic responsiveness in vivo. RNA profiling of Tlr3+/+ (but not Tlr3-/-) tumor cells exposed to anthracyclines revealed a strong IFN/viral fingerprint, indispensable for the tumoricidal activity. Neutralization by antibodies or genetic defects affecting tumor –associated TLR3 or IFNAR1/2 compromised chemotherapy-induced CXCL10 release and tumor control unless exogenous IFNαβ or CXCL10 are concomitantly supplied to anthracyclines. Moreover, chemoresistance of tumors treated by drugs failing to induce a viral signature can be reversed by exogenous Type I IFN. Finally, the IFN fingerprint of human breast cancers allowed to predict tumors proned to benefit from adjuvant anthracyclines. From an evolutionary viewpoint, while tumors (like viruses) have evolved mechanisms to evade an IFN response, chemotherapy-induced viral mimicry might contribute to bypass such as immunoediting
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Ferreira, Ana Rita Filgueiras. „Hepatitis C virus and peroxisomes : evasion from the cellular antiviral response“. Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14348.
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Mestrado em Biomedicina MolecularHepatitis C virus (HCV) causes the most prevalent viral infection worldwide. Upon infection, the HCV genome is detected by the RIG-I-MAVS signalling pathway leading to the production of direct antiviral effectors. NS3/4A protease is the main inhibitor of innate immunity against HCV and it was found to inhibit the mitochondrial signalling protein (MAVS). MAVS was recently found to localize at peroxisomes coordinating with mitochondria the activation of effective antiviral response. Peroxisomal MAVS is responsible for inducing a rapid but short termed antiviral response that is IFNindependent, contrary to mitochondrial MAVS which is associated with the activation of an IFN-dependent antiviral response with delayed kinetics. With this work we aimed at evaluating the effect of NS3/4A over the peroxisomal– MAVS pathway. Our results showed that the MAVS localizing exclusively at peroxisomes is targeted by the HCV NS3/4A protease. We also show that the MAVS cleavage by NS3/4A impaired the antiviral response mediated by peroxisomal-MAVS. These results reaffirm the importance of peroxisomes for viral-host interaction and in antiviral defences. Further studies are proposed in order to better understand the role of this organelle in innate immunity. These may lead to the improvement of therapy against HCV infection.
O vírus da hepatite C (VHC) provoca a infeção viral mais prevalente em todo o mundo. Após infeção, o genoma do VHC é detetado pela via de sinalização RIGI- MAVS levando à produção de efetores diretos da resposta antiviral. A protease NS3/4A é o principal inibidor da resposta imune produzido pelo VHC e foi descrito como inibidor da proteína MAVS. A proteína MAVS foi recentemente localizada nos peroxissomas que, juntamente com a mitocôndria, coordenam a resposta antiviral. A MAVS peroxisomal é responsável pela indução de uma resposta antiviral rápida mas de curta duração que é independente de interferões, mas pelo contrário, a MAVS mitocondrial está associada a uma ativação da resposta antiviral que é dependente de interferões mas que se caracteriza por uma cinética retardada. O nosso objetivo com este trabalho consistiu em avaliar o efeito da NS3/4A na via de sinalização coordenada pelos peroxissomas. Os nossos resultados mostram que a MAVS localizada nos peroxissomas é alvo da protease NS3/4A do VHC. Também mostramos que a clivagem da proteína MAVS pela NS3/4A inibe a resposta antiviral mediada pela MAVS peroxissomal. Estes resultados reafirmam a importância dos peroxissomas na interação vírushospedeiro e na defesa antiviral. Futuros estudos são aconselhados para que se compreenda a função dos peroxissomas na imunidade inata. Estes podem levar a uma melhoria na terapia da infeção pelo VHC.
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Stiltner, Brandon Chase. „Macro Fiber Composite Actuated Control Surfaces with Applications Toward Ducted Fan Vehicles“. Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/34441.
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In most man-made flight, vehicle control is achieved by deflecting flaps. However, in nature, morphing surfaces are found on both flying and swimming creatures. Morphing is used in nature because it is a more efficient form of control. This thesis investigates using morphing flaps to control a class of UAVs known as ducted fan vehicles. Specifically, this thesis discusses both the challenges and benefits of using morphing control surfaces.
To achieve morphing, a piezoelectric device known as Macro Fiber Composites is used. These devices are embedded in the skin of the vehicles control surface, and when actuated, they cause the control surface to increase or decrease camber. This thesis describes experiments that were performed to investigate the performance of this type of actuator. Specifically, the actuation bandwidth of these devices is presented and compared to a servo. Results show that the morphing control surfaces can actuate at frequencies twice as high as a servo.
Master of Science