Thematische Bibliographien / Masaryk Oncology Institute in Brno

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Auswahl der wissenschaftlichen Literatur zum Thema „Masaryk Oncology Institute in Brno“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 13. Februar 2022

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Zeitschriftenartikel zum Thema "Masaryk Oncology Institute in Brno"

Pešová, Zdeňka, Monika Náležinská, Marie Dvořáková, Jana Kocurková und Josef Chovanec. „Ostacles of the daily care of patients with permanent urine catether following radical gynae-oncological surgical procedure in Masaryk Memorial Cancer Institute, Brno, Czech Republic“. Onkologie 14, Nr. 2 (02.06.2020): 100–102. http://dx.doi.org/10.36290/xon.2020.019.

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Grell, Peter, Vit Kandrnal, Bortlicek Zbynek und Rostislav Vyzula. „Lapatinib efficacy according to metastatic sites in trastuzumab pretreated patients with HER2-positive metastatic breast cancer: An analysis form IntERB registry in the Czech Republic.“ Journal of Clinical Oncology 30, Nr. 15_suppl (20.05.2012): e11072-e11072. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e11072.

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e11072 Background: Lapatinib is an oral dual tyrosin kinase inhibitor of EGFR and HER2 and compared to trastuzumab penetrates to CNS. We evaluated efficacy and safety of lapatinib treatment according to different metastatic sites involvement using data from IntERB registry that has been initiated and run by Czech Society for Oncology and Institute of Biostatistics and Analyses at Masaryk University, Brno, Czech Republic. Methods: An analysis included 213 patients with HER2 positive metastatic breast cancer treated from January 2007 to September 2011. Lapatinib was mostly administered orally 1250mg/day with capecitabine (2000mg/m2 D1-14), 16 patients received lapatinib in monotherapy. All patients had experienced progression during prior trastuzumab based therapy. Results: Median age was 56 years (range 23 – 78). Median duration of lapatinib therapy was 20.6 weeks (range 1–146). Complete response was achieved in 13 patients (6.1%), partial response in 31 (14.6%), stable disease in 118 (55.4%). In 26 disease have progressed (12.2%); response could not be assessed in 25 patients (11.7%). PFS for whole group was 7.1 months (95% CI 5.9-8.5). Overall survival was 17.2m (95% CI 15.8-18.6), probability of 6m OS was 80.3% and 1-year OS was 64%. Metastatic sites specific survival was evaluated in 103 patients. CNS dissemination was initially diagnosed in 31 patients (30.1%), PFS in this group was 6.2m (95% CI 3.3-9.1), OS was not reached, 6-m OS was 67.3%. In non-CNS group (skeletal metastasis in 49.5%, lung 38.8%, hepatic 36.9%, lymphatic 17.5%, other 15.5%) was PFS 6.3m (95% CI 1.6-11.1), OS 22.0m (95% CI 15.3-28.8) and 6-m OS was 88.2%. Most common toxicities were diarrhea in 11.7% patients, rash/skin toxicity in 10.8%, nausea/vomitus in 5.2% and hepatotoxicity in 2.3%. No cardiac toxicity was reported. Therapy was discontinued due toxicity in 9.0%. Conclusions: Lapatinib in combination with capecitabine proved its efficacy in trastuzumab pretreated HER2 positive metastatic breast cancer. Even in patients with CNS involvement was achieved a notable PFS and OS, comparable to non-CNS group of patients. Therapy was well tolerated.

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Mlejnková, Hana, und Zdenka Žáková. „Use of microbiological and biological methods for monitoring the influence of diffuse pollution on reservoir's water quality“. Water Science and Technology 33, Nr. 4-5 (01.02.1996): 341–47. http://dx.doi.org/10.2166/wst.1996.0524.

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The research results of water supply reservoirs and their tributaries in the Morava River basin showed the important role of the biological and microbiological investigations by monitoring the influence of diffuse pollution on the reservoir's water quality. Our report brings the critical evaluation of the possibility to use some microbiological and biological methods by monitoring of diffuse pollution, it also includes some practical results received from monitoring the streams and reservoirs within the Morava River basin (in the frame of research projects of the T. G. Masaryk Water Research Institute, branch office Brno).

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Macháčková, Eva, Jana Házová, Eva Sťahlová Hrabincová, Petra Vašíčková, Marie Navrátilová, Marek Svoboda und Lenka Foretová. „Retrospective NGS Study in High-risk Hereditary Cancer Patients at Masaryk Memorial Cancer Institute“. Klinicka onkologie 29, Suppl 1 (15.01.2016): S35—S45. http://dx.doi.org/10.14735/amko2016s35.

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Mełgieś, Katarzyna. „CURRENT HEALTH LAW ISSUES IN CENTRAL AND EASTERN EUROPE(LUBLIN, 3 JUNE 2016, CONFERENCE REPORT)“. Review of European and Comparative Law 2627, Nr. 34 (31.12.2019): 225–29. http://dx.doi.org/10.31743/recl.5077.

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On 3 June 2016 an international conference on Current Health Law Issues in Central and Eastern Europe took place at the John Paul II Catholic University of Lublin. The conference was organised by the Department of Administrative Law at the Faculty of Law, Canon Law and Administra-tion under the honorary patronage of the European Association of Health Law (EAHL). The aim of the above-mentioned meeting was to create the platform for exchange of experiences and sharing views by researches and experts from the field of health law from post-communist countries where transformation processes caused many changes in the health system, also in the perspective of their EU memberships. The foreign research centres represented at the conference were the Masaryk University in Brno from the Czech Republic, the National Academy of Management in Kiev and the Legislation Institute of Verkhovna Rada of Ukraine from Ukraine, the University of Ljubljana from Slovenia, and the Kauno Kolegija University of Applied Sciences from Lithuania. Polish speakers and other participants derived, among others, from the Medical University of Lublin, the Jagiel-lonian University, the University of Rzeszów and the John Paul II Catholic University of Lublin.

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Zelenková, Anna. „Folklorist and Ethnological Research Supported by the Board for the Research of Slovakia and Subcarpathian Ruthenia in Prague during the Interwar Period“. Slovenský národopis / Slovak Ethnology 68, Nr. 1 (01.03.2020): 84–98. http://dx.doi.org/10.2478/se-2020-0005.

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AbstractThe paper focuses on selected folklorist and ethnological activities during the inter-war period, financially supported by the Board for the Research of Slovakia and Subcarpathian Ruthenia, which was established on the initiative of T. G. Masaryk as part of the newly created Slavic Institute in Prague in 1928. This institution aimed to support links between Slovakia and the so-called Czech historical lands and the expressions of “mutuality” in the scientific, cultural or ethnic and language area, etc. The Board provided grants for conducting dialectological, folklorist, geographical and other projects, e.g. for the collection initiative of F. Wollman and his students in Bratislava and Brno in 1928–1947, covering Slovak and (yet unprocessed) Moravian folk fiction. Support was also granted to the research of music culture (D. Orel, K. Hudec, F. Zagriba, etc.), the collection of anthropological and ethnographical materials (K. Chotek, K. Domin, etc.), the study of Slovak folk embroidery (V. Pražák), folklore customs and practices (P. Bogatyrev), folk wood architecture (V. Sičynskyj, D. Stránská), Slovak dialects studied, for example, by V. Vážný, member of the Board, etc. The Slovak Encyclopaedia project, today already forgotten, was not completed. Its editors included historian V. Chaloupecký and, in particular, K. Chotek who prepared the concept of the work in 1930.

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Keith, Daniel. „Book Review: Lubomír Kopeček, ed., Trajectories of the Left: Social Democratic and (ex-) Communist Parties in Contemporary Europe: Between Past and Future. Institute for Comparative Political Research (ISPO), Masaryk University, Brno, 2005 (pbk), 179 pp. ISBN 80 7325 078 0“. Party Politics 15, Nr. 3 (Mai 2009): 397–99. http://dx.doi.org/10.1177/13540688090150030803.

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Pink, Michal, und Adam Folvarčný. „The Czech Pirate Party“. Intersections 6, Nr. 4 (23.12.2020). http://dx.doi.org/10.17356/ieejsp.v6i4.610.

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In 2017, in addition to the traditional, old, and more recently established political parties, a new formation – the Czech Pirate Party – espousing more participative principles, including the use of online platforms for discussions – arrived on the political scene in the Czech Republic. This newcomer to the parliamentary ecosystem, shortly after achieving success at the national level, also managed to attract significant support in local elections. For this reason, there is currently a Pirate Party parliamentary group present in the Chamber of Deputies (the lower chamber of the Czech parliament), while simultaneously the mayor of Prague and members of the ruling coalition in Brno – the second biggest city in the Czech Republic – also represent the Pirate Party. Furthermore, recent opinion polls show support for the Pirates running at about 14%. This is coupled with another new feature: the young age of the party’s elected parliamentarians and local councilors, which brings new challenges to politics. After the elections, a number of commentators immediately dubbed the Pirate Party a ‘youth party.’ But is this really the case? What forms of participation do the party and/or its members use and encourage? This article offers answers to these questions. In particular, it presents the electoral base of this new political party through interpretative analysis. The data are based on election results triangulated with other sources – specifically, a Czech election study is juxtaposed against a quantitative survey carried out by three academic institutions in the Czech Republic (the Faculty of Social Studies at Masaryk University, Brno; Palacký University, Olomouc; and the Institute of Sociology at the Czech Academy of Sciences, Prague). These statistical tools enable us to identify in great detail the demographic and socio-economic characteristics of Pirate Party voters (for instance: age, education, their views about contemporary democracy, and the timing of their decision to vote) and map their attitudes towards other parties and their leaders. The article reveals how popular the Czech Pirate Party is among the younger generation of voters, where the latter come from, and what political preferences they had previously.

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Foretova, Lenka, Marie Navratilova, Marek Svoboda, Petr Grell, Libor Nemec, Lukáš Sirotek, Radka Obermannova et al. „GAPPS – Gastric Adenocarcinoma and Proximal Polyposis of the Stomach Syndrome in 8 Families Tested at Masaryk Memorial Cancer Institute – Prevention and Prophylactic Gastrectomies“. Klinicka Onkologie 32, Suppl 2 (15.08.2019). http://dx.doi.org/10.14735/amko2019s109.

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Baldík, Vít, Hana Krumlová, David Buriánek, Eva Kryštofová, Jana Janderkova, Jan Sedláček, Roman Novotný und Martin Dostalík. „MOBILIZACE CHEMICKÝCH SLOŽEK STRUSKOVÉ DEPONIE V NÁRODNÍ PŘÍRODNÍ REZERVACI RUDICKÉ PROPADÁNÍ“. Geologické výzkumy na Moravě a ve Slezsku 25, Nr. 1-2 (17.12.2018). http://dx.doi.org/10.5817/gvms2018-1-2-108.

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The Rudice swallow hole (Rudické propadání) National Nature Monument is a locality affected by occasional mass movements and landslides. During exceptional rainfall events, the slag material from the slopes of a small valley called “Ve struskách” (“In the Slags”) slides into an episodic stream, which enters the local karst system near the swallow hole of the Jedovnice Creek (Jedovnický potok).The slag was dumped in the locality in consequence of the past processing of iron ore in blast furnaces, which had been built near Jedovnice by the princely Salm family in the 19th century. Even though the blast furnaces were closed down a hundred years ago, the slag components leaking into the Rudice stream sink cave system still demonstrably damage the speleothems. This was the majorimpulse for us to have a closer look at the geochemical properties of the slag.The chemical composition was determined by silicate analyses carried out in the Institute of Geological Sciences at the Faculty of Sciences of the Masaryk University in Brno and in the ACME laboratories in Canada. The ACME laboratories determined heavy metal contents by atomic absorption spectroscopy (AAS) and by inductively coupled plasma mass spectrometry (ICP-MS). The petrographic characterization of the slag and its enclosures was conducted based on point analyses by a wavelength dispersive X ray (WDX) electron microprobe. Predictions regarding the geochemical behavior of the slag components in an aqueous environment were made using the sequential extraction analysis (SEA) according to Tessier (1979).We have found the expected spatial variability of the basic chemical composition of the slag dumps, as well as the presence of heavy metals (cadmium and especially zinc are present at high concentrations).The slag material exhibits a glassy amorphous structure containing occasional mineral crystals, droplets of pure or oxidized iron and fragments of other materials (such as charcoal or blast furnace bricks). The ongoing weathering of the slag is accompanied by oxidation of crude iron and formation of limonite. Apart from that, the material is not subject to signifi cant secondary transformations. The results of the sequential extraction analyses of slag and soil samples suggest that Cd and Zn are chemically bound to the “carbonate fraction”, which, in general, tends to dissolve under acidic conditions. Even though the environment of the carbonate rock cave systems is typically alkaline, there is a persisting risk of mobilization of heavy metals by acid soil solutions. From the environmental point of view, the slag deposition primarily represents a source of clastic material, which contaminates the cave system and damages speleothems by mechanical abrasion.

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