Auswahl der wissenschaftlichen Literatur zum Thema „Marqueurs redox“
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Zeitschriftenartikel zum Thema "Marqueurs redox"
Baudin, Bruno. „Enfin des marqueurs redox“. Revue Francophone des Laboratoires 2020, Nr. 522 (Mai 2020): 21. http://dx.doi.org/10.1016/s1773-035x(20)30158-1.
Der volle Inhalt der QuelleBAHLIL, Yasmina, Djamil KROUF und Nawal TALEB-DIDA. „Zygophyllum album aqueous extract reduces oxidative damage in erythrocytes and attenuates pro-inflammatory markers in hypercholesterolemic-diabetic rats“. Nutrition & Santé 09, Nr. 02 (16.12.2020): 106–16. http://dx.doi.org/10.30952/ns.9.2.6.
Der volle Inhalt der QuelleMendes Hacke, Ana Carolina, Taynara Valério, Mateus Cubo, Dhésmon Lima, Christiana Pessoa und Romaiana Pereira. „Antioxidant Capacity of Myrciaria Cauliflora Seeds Extracts By Spectrophotometric, Biochemical and Electrochemical Methods Preferred Presentation“. ECS Meeting Abstracts MA2022-01, Nr. 43 (07.07.2022): 1868. http://dx.doi.org/10.1149/ma2022-01431868mtgabs.
Der volle Inhalt der QuelleMathias, Roberta Filgueiras. „Caminhos do Carnaval“. Arquivos do CMD 5, Nr. 2 (16.01.2019). http://dx.doi.org/10.26512/cmd.v5i2.22015.
Der volle Inhalt der QuelleBarboni, Paulo. „n. 210 (18): Dor On Line“. Dor on line, Nr. 210 (30.01.2018). http://dx.doi.org/10.26512/dol.v0i210.16416.
Der volle Inhalt der QuelleDissertationen zum Thema "Marqueurs redox"
Gaillard, Michel. „Nouveaux marqueurs électroactifs pour le développement de biocapteurs environnementaux“. Electronic Thesis or Diss., Perpignan, 2023. https://theses-public.univ-perp.fr/2023PERP0054.pdf.
Der volle Inhalt der QuelleNowadays, climate change, anthropogenic releases and the increase in the world's population are contributing to an increase in the number of bacteria of concern, drug releases and toxins into the environment. Ochratoxin A, estradiol, and some bacteria are among the contaminants polluting nature and threatening the health of living beings. In order to detect these potentially harmful elements, we worked on the development of an original oligonucleotide labeling. This marking is based on the use of electroactive metal complexes such as redox probes.These complexes are based on the macrocycle ligands DOTA and NOTA, usually mainly used in medical imaging, functionalized with iron (III). The study of their electrochemical properties, carried out by cyclic voltammetry, has shown that they have many advantages competing with the most common redox compounds. In particular, we sought to apply this oligonucleotide labeling to the construction of biosensors, with the first test of a genosensor for the detection of DNA from Vibrio bacteria. Sensor design and target detection were followed by impedance spectroscopy. However, impedance analysis did not achieve the expected results, and in order to extend the scope of our study, another method was tested. Therefore, we sought to couple metal complexes directly to aptamers via a reaction between a thiol function and a maleimide. In the next step, the biosensors were built by immobilizing the modified aptamers on electrodes. In parallel, aptamer-target interactions were quantified by thermophoresis or MST analyses to confirm certain results and validate the binding characteristics of aptamers
El, Banna Nadine. „La génération du stress oxydant comme stratégie thérapeutique anticancéreuse : Investigation des mécanismes d’action de la vitamine C, de l’auranofin et de leur combinaison“. Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS232.
Der volle Inhalt der QuelleReactive oxygen and nitrogen species (ROS, RNS) homeostasis and intracellular reductive/oxidative (redox) dynamics play a key role in regulating cell fate and are critical for normal cellular functions. Oxidative stress via the disruption of redox homeostasis can lead to aberrant cell signaling and toxic oxidative damage of DNA, lipids and proteins, and is therefore associated with human pathologies such as cancers. Cancer cells experience extensive redox deregulation and generally exhibit higher intrinsic basal oxidative stress than normal cells, as a consequence, they are more dependent on their antioxidant systems for survival. Thus, the administration of a drug generating additional ROS / RNS or inhibiting cellular antioxidant systems will exert a selective cytotoxicity towards cancer cells while sparing their normal counterparts. This is the biological basis for « redox-based anticancer therapy ». The work described here aims to investigate the redox-based anticancer activity of vitamin C (VitC) and auranofin (AUF), as single drugs or in combination, in breast cancer model. VitC at high pharmacological concentrations shows pro-oxidant properties. In this study, we showed that VitC anticancer activity against breast cancer cell lines was associated to extracellular and intracellular generation of hydrogen peroxide (H₂O₂), accompanied by the oxidation of intracellular glutathione (GSH). A “redoxome” proteomics approach revealed that VitC induces alterations of the redox state of key antioxidant enzymes and a number of cysteines-containing proteins including many proteins involved in RNA and DNA metabolisms and energetic processes. Cell cycle arrest and translation inhibition are associated with VitC-induced cytotoxicity. Finally, bioinformatics analysis and biological experiments identified that peroxiredoxin 1 (PRDX1) expression levels correlate with VitC differential cytotoxicity in breast cancer cells. AUF, an antirheumatic drug and known inhibitor of thioredoxin reductases, has been repurposed recently as a potent anticancer drug. We showed that AUF acts on both the thioredoxin and GSH systems and its impact on GSH system is essential for its anticancer activity. AUF alters the redox state of a number of nucleic acid-binding proteins involved in cell proliferation, cell division and cell cycle, triggering dNTP depletion and cell cycle arrest. Importantly, we observed that the combination of AUF and VitC reveals a synergetic and H₂O₂-mediated cytotoxicity towards MDA-MB-231 cells and other breast cancer cell lines without much impact on normal cells, thus decreasing the cytotoxic concentrations of AUF or VitC single drug. The anticancer potential of AUF/VitC combinations was validated in vivo on MDA-MB-231 xenografts in mice without notable side effects, while administration of AUF or VitC as a single agent failed to suppress tumor growth. Finally, SILAC proteomics, bioinformatics analysis, and functional experiments linked prostaglandin reductase 1 (PTGR1) expression levels with breast cancer cell response to AUF/VitC combination, thus identifying a potential predictive biomarker. Overall, these results provide new insights into the anticancer mechanisms of VitC and AUF, as single drugs and in combination. In particular, this combination of two non-toxic and commonly available drugs could be efficient against triple-negative breast cancer and potentially other cancers with similar redox properties. Further assessment in preclinical and clinical studies of these drugs and combinations could open new avenues for redox-based anticancer therapy
Schifano, David. „Étude des mécanismes de base de la dégradation chimique de l'acide nitrilotriacétique, ligand utilisé dans les procédés redox de conversion d'H2S en soufre élémentaire“. Lille 1, 2004. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2004/50376-2004-143.pdf.
Der volle Inhalt der QuelleTabey, Alexis. „Synthèse de nouveaux complexes aryl-palladium et aryl-or pour le marquage par du monoxyde de carbone de composés bioconjugués supportés et pour des réactions de couplages“. Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0025/document.
Der volle Inhalt der QuelleThe growth of organometallic chemistry has allowed numerous developments in the field of medical diagnosis, especially for Positron Emission Tomography (PET). Developing new methodologies for the synthesis of biological tracers by a last-step 11C labeling, our team has been recently able to take advantage of the great functional tolerance of palladium-catalyzed carbonylation to achieve this goal. A new synthetic strategy involving preformed palladium complexes is described in this manuscript. Their anchoring on a polystyrene resin allowed subsequently to facilitate the carbonylation process by simplifying the purification. New palladium complexes have also been investigated for their potential photoredox applications. Finally, new coupling strategies implying gold (III) intermediates and photoredox catalysis being a very attractive subject, new gold complexes have been synthetized in order to investigate the reaction mechanisms that could operate. Possibilities of asymmetric induction in the synthesis of atropoisomeric biaryl compounds were also studied
Limoges, Benoît. „Contribution au developpement et a la mise au point d'une nouvelle technique de dosage immunologique de medicaments a l'aide d'une electrode modifiee par un film polymere de nafion et de medicaments marques par un groupement redox cationique ou procationique“. Clermont-Ferrand 2, 1993. http://www.theses.fr/1993CLF21534.
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