Thematische Bibliographien / Macrocycles

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Bücher
  4. Buchteile
  5. Konferenzberichte
  6. Berichte der Organisationen

Auswahl der wissenschaftlichen Literatur zum Thema „Macrocycles“

Autor: Grafiati
Veröffentlicht am 4. Juni 2021
Zuletzt aktualisiert am 16. November 2024

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Zeitschriftenartikel zum Thema "Macrocycles"

1

Abdelraheem, Eman, Shabnam Shaabani und Alexander Dömling. „Artificial Macrocycles“. Synlett 29, Nr. 09 (07.05.2018): 1136–51. http://dx.doi.org/10.1055/s-0036-1591975.

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Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse access to large macrocycles chemical space. One synthetic technology to access artificial macrocycles with potential biological activity, multicomponent reactions, is reviewed here, with a focus on our own work. We believe that synthetic chemists have to acquaint themselves more with structure and activity to leverage the design aspect of their daily work.1 Introduction2 Macrocycle Properties and Receptor Binding3 Synthetic Approaches towards Artificial Macrocycles Using MCR4 Design Rules for Membrane Crossing Macrocycles5 Design Rules for Libraries of Macrocycles6 Computational Macrocyclic Methods7 Future View
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Singh, Kartikey, und Rama Pati Tripathi. „An Overview on Glyco-Macrocycles: Potential New Lead and their Future in Medicinal Chemistry“. Current Medicinal Chemistry 27, Nr. 20 (07.06.2020): 3386–410. http://dx.doi.org/10.2174/0929867326666190227232721.

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Macrocycles cover a small segment of molecules with a vast range of biological activity in the chemotherapeutic world. Primarily, the natural sources derived from macrocyclic drug candidates with a wide range of biological activities are known. Further evolutions of the medicinal chemistry towards macrocycle-based chemotherapeutics involve the functionalization of the natural product by hemisynthesis. More recently, macrocycles based on carbohydrates have evolved a considerable interest among the medicinal chemists worldwide. Carbohydrates provide an ideal scaffold to generate chiral macrocycles with well-defined pharmacophores in a decorated fashion to achieve the desired biological activity. We have given an overview on carbohydrate-derived macrocycle involving their synthesis in drug design and discovery and potential role in medicinal chemistry.
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Zhong, Chunxiao, Yong Yan, Qian Peng, Zheng Zhang, Tao Wang, Xin Chen, Jiacheng Wang, Ying Wei, Tonglin Yang und Linghai Xie. „Structure–Property Relationship of Macrocycles in Organic Photoelectric Devices: A Comprehensive Review“. Nanomaterials 13, Nr. 11 (27.05.2023): 1750. http://dx.doi.org/10.3390/nano13111750.

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Macrocycles have attracted significant attention from academia due to their various applications in organic field-effect transistors, organic light-emitting diodes, organic photovoltaics, and dye-sensitized solar cells. Despite the existence of reports on the application of macrocycles in organic optoelectronic devices, these reports are mainly limited to analyzing the structure–property relationship of a particular type of macrocyclic structure, and a systematic discussion on the structure–property is still lacking. Herein, we conducted a comprehensive analysis of a series of macrocycle structures to identify the key factors that affect the structure–property relationship between macrocycles and their optoelectronic device properties, including energy level structure, structural stability, film-forming property, skeleton rigidity, inherent pore structure, spatial hindrance, exclusion of perturbing end-effects, macrocycle size-dependent effects, and fullerene-like charge transport characteristics. These macrocycles exhibit thin-film and single-crystal hole mobility up to 10 and 26.8 cm2 V−1 s−1, respectively, as well as a unique macrocyclization-induced emission enhancement property. A clear understanding of the structure–property relationship between macrocycles and optoelectronic device performance, as well as the creation of novel macrocycle structures such as organic nanogridarenes, may pave the way for high-performance organic optoelectronic devices.
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Fan, Linmeng, Min Du, Lichun Kong, Yan Cai und Xiaobo Hu. „Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection“. Molecules 28, Nr. 3 (31.01.2023): 1338. http://dx.doi.org/10.3390/molecules28031338.

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Traditional macrocyclic molecules encode recognition sites in their structural backbones, which limits the variation of the recognition sites and thus, would restrict the adjustment of recognition properties. Here, we report a new oligoamide-based macrocycle capable of varying the recognition functional groups by post-synthesis modification on its structural backbone. Through six steps of common reactions, the parent macrocycle (9) can be produced in gram scale with an overall yield of 31%. The post-synthesis modification of 9 to vary the recognition sites are demonstrated by producing four different macrocycles (10–13) with distinct functional groups, 2-methoxyethoxyl (10), hydroxyl (11), carboxyl (12) and amide (13), respectively. The 1H NMR study suggests that the structure of these macrocycles is consistent with our design, i.e., forming hydrogen bonding network at both rims of the macrocyclic backbone. The 1H-1H NOESY NMR study indicates the recognition functional groups are located inside the cavity of macrocycles. At last, a preliminary molecular recognition study shows 10 can recognize n-octyl-β-D-glucopyranoside (14) in chloroform.
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Guo, Hao, Yu-Fei Ao, De-Xian Wang und Qi-Qiang Wang. „Bioinspired tetraamino-bisthiourea chiral macrocycles in catalyzing decarboxylative Mannich reactions“. Beilstein Journal of Organic Chemistry 18 (02.05.2022): 486–96. http://dx.doi.org/10.3762/bjoc.18.51.

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A series of tetraamino-bisthiourea chiral macrocycles containing two diarylthiourea and two chiral diamine units were synthesized by a fragment-coupling approach in high yields. Different chiral diamine units, including cyclohexanediamines and diphenylethanediamines were readily incorporated by both homo and hetero [1 + 1] macrocyclic condensation of bisamine and bisisothiocyanate fragments. With the easy synthesis, gram-scale of macrocycle products can be readily obtained. These chiral macrocycles were applied in catalyzing bioinspired decarboxylative Mannich reactions. Only 5 mol % of the optimal macrocycle catalyst efficiently catalyzed the decarboxylative addition of a broad scope of malonic acid half thioesters to isatin-derived ketimines with excellent yields and good enantioselectivity. The rigid macrocyclic framework and the cooperation between the thiourea and tertiary amine sites were found to be crucial for achieving efficient activation and stereocontrol. As shown in control experiments, catalysis with the acyclic analogues having the same structural motifs were non-selective.
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Sun, Dianqing. „Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles“. Molecules 27, Nr. 3 (02.02.2022): 1012. http://dx.doi.org/10.3390/molecules27031012.

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Macrocycles represent attractive candidates in organic synthesis and drug discovery. Since 2014, nineteen macrocyclic drugs, including three radiopharmaceuticals, have been approved by FDA for the treatment of bacterial and viral infections, cancer, obesity, immunosuppression, etc. As such, new synthetic methodologies and high throughput chemistry (e.g., microwave-assisted and/or solid-phase synthesis) to access various macrocycle entities have attracted great interest in this chemical space. This article serves as an update on our previous review related to macrocyclic drugs and new synthetic strategies toward macrocycles (Molecules, 2013, 18, 6230). In this work, I first reviewed recent FDA-approved macrocyclic drugs since 2014, followed by new advances in macrocycle synthesis using high throughput chemistry, including microwave-assisted and/or solid-supported macrocyclization strategies. Examples and highlights of macrocyclization include macrolactonization and macrolactamization, transition-metal catalyzed olefin ring-closure metathesis, intramolecular C–C and C–heteroatom cross-coupling, copper- or ruthenium-catalyzed azide–alkyne cycloaddition, intramolecular SNAr or SN2 nucleophilic substitution, condensation reaction, and multi-component reaction-mediated macrocyclization, and covering the literature since 2010.
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Li, Yu, Wei Zhao und Biao Wu. „Tetraurea Macrocycles: Template-Directed One-Pot Synthesis and Anion Binding Properties“. Advances in Engineering Technology Research 6, Nr. 1 (19.06.2023): 228. http://dx.doi.org/10.56028/aetr.6.1.228.2023.

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Given the significance of anion in life, study of anion recognition attracted great attentions in the past decades. Macrocyclic receptors display intriguing anion binding properties; however, the synthesis of macrocycles is challenging. Here, we reported a new strategy of making tetraurea in one-step. By using 1-butyl-3-methylimidazolium ([hmim][X], X = anion) as the solvent and template reagent, tetraurea macrocycle comprised of bis(urea) binding moiety and hexyl chain spacers is selectively formed with high yield. The obtained macrocycles displayed interesting anion binding properties as indicated by single crystal X-ray diffraction structures and computational modelling.
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Chia, PSK, A. Ekstrom, I. Liepa, LF Lindoy, M. Mcpartlin, SV Smith und PA Tasker. „New Macrocyclic Ligands. II. Pendant Hydroxyethyl, Cyanoethyl and Carbamoylethyl Arm Systems Derived From O2N2-Donor Rings: the X-Ray Structure of a Pendant Hydroxyethyl Derivative“. Australian Journal of Chemistry 44, Nr. 5 (1991): 737. http://dx.doi.org/10.1071/ch9910737.

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The syntheses and characterization of 12 new 14- to 17-membered macrocycles incorporating pendant hydroxyethyl cyanoethyl or carbamoylethyl groups are reported. The macrocyclic ring in each of these new ligands contains an O2N2-donor set. The X-ray structure of the di(hydroxyethyl) derivative of the 14-membered macrocycle is described.
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Boyd, Simon, Nuno M. Cabral, Kenneth P. Ghiggino, Martin J. Grannas, W. David McFadyen und Peter A. Tregloan. „Nickel complexation and photophysics of alkylanthracenyl dioxocyclam macrocycle derivatives“. Australian Journal of Chemistry 53, Nr. 8 (2000): 651. http://dx.doi.org/10.1071/ch00106.

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Ligands H2L in which (10-R-anthracen-9-yl)methyl moieties (R = H, Me, Et) are covalently joined (6-position) to the 5,7-dioxocyclam macrocycle framework have been prepared and their nickel(II) complexes isolated and characterized. X-Ray crystal structures of NiIIL (R = H, Me) complexes show that in both structures the anthracene moieties are folded around towards the mean plane of the macrocycles; dihedral angles between the mean anthracene and macrocyclic planes of c. 22˚ are subtended. 1H n.m.r. spectrometry indicates that the folded conformations are retained in solution. Absorption and fluorescence spectra, fluorescence quantum yields and lifetimes of the anthracenyl macrocycles are reported. Absorption spectra of the metal complexes are red-shifted and the fluorescence is dramatically quenched compared to the metal-free compounds indicating a strong electronic interaction between the anthracene and the complexed dioxocyclam macrocycle.
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Hosseinzadeh, Parisa, Gaurav Bhardwaj, Vikram Khipple Mulligan, Matthew D. Shortridge, Timothy W. Craven, Fátima Pardo-Avila, Stephen A. Rettie et al. „Comprehensive computational design of ordered peptide macrocycles“. Science 358, Nr. 6369 (14.12.2017): 1461–66. http://dx.doi.org/10.1126/science.aap7577.

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Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent therapeutics identified to date, but there is currently no way to systematically search the structural space spanned by such compounds. Natural proteins do not provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrophobic cores, and can contain local structures not accessible with l-amino acids. Here, we enumerate the stable structures that can be adopted by macrocyclic peptides composed of l- and d-amino acids by near-exhaustive backbone sampling followed by sequence design and energy landscape calculations. We identify more than 200 designs predicted to fold into single stable structures, many times more than the number of currently available unbound peptide macrocycle structures. Nuclear magnetic resonance structures of 9 of 12 designed 7- to 10-residue macrocycles, and three 11- to 14-residue bicyclic designs, are close to the computational models. Our results provide a nearly complete coverage of the rich space of structures possible for short peptide macrocycles and vastly increase the available starting scaffolds for both rational drug design and library selection methods.
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Dissertationen zum Thema "Macrocycles"

1

Azarias, Cloé. „Modeling azacalixphyrin macrocycles“. Thesis, Nantes, 2018. http://www.theses.fr/2018NANT4021/document.

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Cette thèse porte sur la modélisation des propriétés structurales, aromatiques et spectroscopiques d'une nouvelle classe de macrocycles alternatifs aux porphyrines, les azacalixphyrines (ACPs). Ces macrocycles conjugués, synthétisés et caractérisés pour la première fois en 2010 par le groupe d’Olivier Siri à Marseille, ont montré des propriétés exceptionnelles (structure, absorption, tautomérie, et complexation). Cette thèse vise à proposer de nouveaux dérivés aux propriétés améliorées, notamment en ce qui concerne leur absorption, en utilisant les outils offerts par la chimie théorique. Parmi toutes les approches ab initio permettant de modéliser les ACPs, la théorie fonctionnelle de la densité (DFT) et sa forme dépendante du temps (TDDFT) ont été principalement appliquées, bien que des calculs utilisant des méthodes alternatives aient également été effectués, notamment à l'aide du formalisme Bethe-Salpeter (BSE/evGW) dans le cadre d'une collaboration avec l'équipe du Dr. Xavier Blase à Grenoble. Trois stratégies chimiques ont été évaluées: (i) l’extension de la délocalisation des électrons  en fusionnant plusieurs unités ACP; (ii) la substitution de l’ACP via l'addition de groupes électroactifs; et (iii) le couplage du macrocycle avec un fluorophore présentant une absorption complémentaire afin d'absorber la lumière sur une plus grande gamme du spectre et déclencher des processus de transfert d'énergie entre les sous-unités. Les deux premiers axes ont été réalisés en collaboration avec l'équipe d’Olivier Siri alors que le dernier est le fruit d'une collaboration avec le groupe de Benedetta Mennucci à Pise
This thesis focuses on the modeling of the structural, aromatic, and spectroscopic properties of a new class of macrocycles alternative to porphyrins, i.e., azacalixphyrins (ACPs). These conjugated macrocycles have first been synthesized and characterized in 2010 by Siri’s group in Marseille and revealed exceptional features (structure, NIR absorption, tautomerism, and complexation). This thesis aimed at using ab initio methods to propose new ACP derivatives with improved properties with a focus on their absorption. The Density Functional Theory (DFT) and Time- Dependent DFT (TD-DFT) methods have been predominantly applied, although alternative wavefunction-based theories [the second-order Coupled-Cluster, CC2, and the Algebraic Diagrammatic Construction, ADC(2)] as well as the Bethe-Salpeter formalism, BSE/evGW, have also been used. Three major directions to develop new ACP derivatives have been investigated: (i) the extension of the ACP -conjugation path by fusing several ACP moieties leading to multimers; (ii) chemical modifications of the ACP unit by addition of electroactive groups; and (iii) coupling of the ACP moiety with a fluorophore presenting a complementary absorption spectrum in order to improve the light harvesting and to trigger excitation energy transfer processes. The two former axes have been investigated in collaboration with Siri’s team whereas the latter has arisen from a collaboration with the Mennucci’s group
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Danso-Danquah, Richmond Edward. „Syntheses of polypyrrolic macrocycles“. Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26240.

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Pentaphyrins are pentapyrrolic macrocycles containing five bridging methine groups between the five pyrrolic subunits. The syntheses of decamethylpentaphyrin 71, 2-ethoxycarbonyl-3,7,8,12,13,17,18,22,23-nonamethylpentaphyrin 74, 2-ethoxycarbonyl-3,7,8,22,23-pentamethyl-12,13,17,18-tetraethylpentaphyrin 75, 3,12-dimethoxycarbonylethyl-2,7,8,-13,17,18,22,23-octamethylpentaphyrins 29 and the zinc complexes of 71 and 74 are described. The physical properties of the pentaphyrins show them to be aromatic like sapphyrins, porphyrins and corroles. This aromaticity is reflected in the large shielding of the NH protons and the deshielding of the methine protons in the nmr spectra and by their optical spectra, which exhibit Soret and visible bands similar to sapphyrins and porphyrins.
Science, Faculty of
Chemistry, Department of
Graduate
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Norman, Timothy John. „Radioimmunotherapy with yttrium macrocycles“. Thesis, Durham University, 1994. http://etheses.dur.ac.uk/5529/.

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Monoclonal antibody fragments (Fab') which recognise tumour-associated antigens provide an ingenious means of selectively targeting a therapeutic radionuclide to a tumour for radioimmunotherapy. The radionuclide yttrium-90, a long range β(^-) emitter, was chosen to deliver a sterilising dose of radiation to the tumour. A selection of novel functionalised macrocyclic ligands based on a 1,4,7,10-tetraazacyclododecane skeleton have been synthesised, and the stabilities of their yttrium (III) and gadolinium (III) complexes studied in vitro through association and dissociation measurements, and in vivo through animal biodistribution studies. The radiolabelled complexes do not dissociate in vivo. Maleimides are compounds which are capable of selectively reacting with a thiol of an antibody fragment. Selective functionalisation of one of the yttrium binding macrocyclic ligands with either one or three maleimides has been carried out, and the resulting compounds conjugated to tumour seeking humanised antibody fragments. Subsequent radiolabelling with (^90)Y, gave the desired tumour targeting drug for use in radioimmunotherapy. Acridines are a class of intercalating agents which are capable of reversibly binding to DNA. A maleimide functionalised ligand derivatised with acridine was formed. Conjugation of this compound to antibody fragments capable of entering a tumour cell, may permit drug binding to tumour cell DNA, and thus enhance the targeting efficacy of the radiolabelled conjugate.
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Matthes, Karen Elizabeth. „Chemistry of functionalised macrocycles“. Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6704/.

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The work reported in this thesis is divided into two distinct areas. The first involves the synthesis of monoaza- and diaza-[12]-ring macrocycles, with differing side-arm N-substituents. The twelve-membered macrocycles possess a convenient ring-size for exploring the stability and selectivity of complexation of small cations, in particular those from groups IA and IIA. Amide substituents on nitrogen were expected to function as effective σ-donors to cations with high charge density (e.g. Li (^+), Ca (^2)(^+)), because of their high ground state dipole moments. The effect of the length of the side-arms attached to nitrogen on the complexation has also been studied. Complexation behaviour has been probed using (^13)C NMR spectroscopy, titration calorimetry, and fast-atom bombardment mass spectroscopy. Copper (II) complexes of three of the [12]-ring cycles have also been characterised by X-ray crystallographic analysis. The second area involves the study of a series of macrocyclic ligands capable of forming homo- and hetero-dinuclear complexes. In particular, ligands containing the pyridyl-dithio (PyS(_2)) binding unit and a polyether chain linking the two sulphur atoms have been examined. The three binding atoms of each PyS (_2) group define three corners of a fairly rigid square planar environment which favours the formation of square planar d(^8) complexes. Accordingly, complexation with rhodium (I) [and (III)], palladium (II), and platinum (II) has been investigated: the structural properties of these complexes have been determined by the use of FT NMR and X-ray crystallography.
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Sloman, Zachary Scott. „Novel thiophene based macrocycles“. Thesis, Nottingham Trent University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297724.

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Marrs, Deborah Jane. „Macrocycles, macrobicycles : a study“. Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257447.

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Colombo-Khater, Dominique. „Macrocycles polyhétéroatomiques : synthèse, complexation“. Toulouse 3, 1993. http://www.theses.fr/1993TOU30001.

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Depuis quelques annees, de nombreux macrocycles phosphores contenant des heteroatomes ont ete prepares dans le but d'obtenir des especes capables de complexer selectivement des cations voire meme des especes neutres. La methode de synthese mise au point au laboratoire en 1988 consiste a faire reagir un dialdehyde sur un phosphodihydrazide. Il s'agit d'une methode simple et generale de synthese de macrocycles polyphosphores. La reaction mise en jeu est une reaction de cyclocondensation 2+2. L'etude bibliographique presentee dans le premier chapitre nous a permis de faire le point sur les differentes methodes de synthese de macrocycles polyheteroatomiques phosphores, silicies et bores. Dans le second chapitre de cette these, nous decrivons la preparation de nouveaux precurseurs phosphores de macrocycles. Le troisieme chapitre decrit la mise au point de deux voies de synthese permettant l'acces aux premiers macrocycles tetraphosphores fonctionnalises ou non, contenant des atomes de phosphore intracycliques a environnement n-p-n et o-p-o. La synthese de macrocycles phosphores possedant des heteroelements des groupes 13 et 14 tels que le silicium et le bore dans la chaine macrocyclique est egalement decrite dans ce chapitre. Enfin quelques aspects de la reactivite et des proprietes de complexation des precurseurs phosphores synthetises dans le second chapitre de ce memoire seront abordes dans cette quatrieme partie. Des complexes macrocycliques ou non du nickel, zirconium, titane et baryum seront decrits. Des monocristaux ont pu etre isoles dans le cas de certains complexes du nickel. L'etude des structures par diffraction de rx sera developpee
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Watson, Walter Philip. „Hybrid Macrocycles for Supramolecular Assemblies“. Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6958.

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Hybrid macrocycles, which chimerically integrate multiple chemical compositions and architectures, provide an effective way to impart new properties to polymers that are not found in their linear or homocyclic analogues. This dissertation addresses the incorporation of hydrophilic blocks into hydrophobic polymer, as either a poly(dimethyl siloxane)-block-poly(oxyethylene) (PDMS-POE) tadpole with a hydrophobic head and a hydrophilic tail or as a diblock poly(styrene)-block-diethylene glycol (PS-DEG) hydrophobic-hydrophilic macrocycle. The supramolecular association properties of both kinds of cycles were studied: the PDMS-POE tadpoles in forming micelles, and the PS-DEG macrocycles in threading with linear polymer to form polyrotaxanes. For the PDMS-POE macrocycle, linear alpha,omega-dihydroxy PDMS was cyclized under dilute conditions with dichloromethylhydrosilane as a linking group to produce hydrosilane-functionalized cyclic PDMS. This was joined to alpha-methoxy,omega-allyl POE via a free radical hydrosilylation reaction to produce the hybrid tadpole macrocycle, which was analyzed by GPC, DSC, and 1H, 13C, and 29Si NMR spectroscopy. Supramolecular aggregation consisting of the formation of micelles under both polar and nonpolar conditions was studied by surface tensiometry and quasielastic light scattering. For the PS-DEG macrocycle, linear alpha,omega-dihydroxy PS was prepared by ATRP polymerization of styrene, followed by reaction with KOH to give hydroxyl endgroups. The linear PS was then cyclized under dilute conditions with diethylene glycol ditosylate, and the product was analyzed by GPC, MALDI-TOF MS, DSC, and 1H, 13C and DOSY NMR spectroscopy. The macrocycle was then statistically threaded with linear PS to give the supramolecular structure poly(styrene)-rotaxa-cyclo[poly(styrene)-block-diethylene glycol]. Characterization was performed with DOSY NMR to verify that the product was threaded, and 1H NMR was collected to determine that the product was 13% macrocycle by weight. DSC showed only one Tg, indicating that the linear and cyclic species were present in the same phase.
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Morphy, John Richard. „Functionalised macrocycles for tumour targeting“. Thesis, Durham University, 1988. http://etheses.dur.ac.uk/6407/.

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Monoclonal antibodies which recognise tumour-associated antigens provide a means of targeting radionuclides selectively to tumour cells. (^99m)Tc and (^64)Cu are potentially useful isotopes for radioimmunoimaging;(^ 90)Y and (^67)Cu may be suitable for radioimmunotherapy. The synthesis of functionalised macrocycles for binding these four radioisotopes to antibodies is described. In each case, a macrocycle has been selected to provide a complex which is kinetically inert, thereby preventing dissociation of the radiolabel in vivo. A novel strategy for conjugating a C-alkylated cyclam derivative (for binding Tc and Cu) to an antibody is described. This method facilitates the selective acylation of an exocyclic primary amino group in the presence of the secondary ring nitrogens. Unfortunately, the labelling of antibody-bound cyclam with (^99m)Tc required conditions (pH 11) which produced extensive binding of the radiolabel to the protein backbone. "Non-specific" (^99m) Tc was subsequently found to dissociate in vivo. Pre-labelling the macrocycle with (^99m)Tc solved the "non-specifics" problem but required a pH which meant that the conjugation step was too slow for sufficient specific activity to be bound. A phenol-pendent derivative of cyclam was found to incorporate (^99m)Tc at a lower pH than cyclam itself. The "non-specific" binding of copper to the protein was minimised using a low pH labelling strategy in conjunction with a chelate wash. Macrocycle antibody conjugates labelled manner provide very promising biodistribution profiles in normal mice. A labelling buffer was selected to enhance the rate of uptake of copper by the macrocycle at low pH. Macrocycle-antibody conjugates containing 13N(_4), which was found to provide faster association kinetics than cyclam, have been prepared and await radiolabelling studies. A derivative of I3N(_4), containing 4 carboxylic acid donor sites, has been functionalised for conjugation to an antibody to act as a (^90)Y binder.
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Wood, Ian. „Hydrogen bonded double helical macrocycles“. Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285635.

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Bücher zum Thema "Macrocycles"

1

Davis, Frank, und Séamus Higson. Macrocycles. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470980200.

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2

E, Weber, Vögtle F. 1939- und Burrell A. K, Hrsg. Macrocycles. Berlin: Springer-Verlag, 1992.

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3

Coppock, Matthew B., und Alexander J. Winton, Hrsg. Peptide Macrocycles. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1689-5.

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4

Bradshaw, J. S. Aza-crown macrocycles. New York: Wiley, 1993.

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Levin, Jeremy, Hrsg. Macrocycles in Drug Discovery. Cambridge: Royal Society of Chemistry, 2014. http://dx.doi.org/10.1039/9781782623113.

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Kim, Kimoon, Hrsg. Cucurbiturils and Related Macrocycles. Cambridge: Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781788015967.

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Marsault, Eric, und Mark L. Peterson, Hrsg. Practical Medicinal Chemistry with Macrocycles. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.

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8

Vögtle, Fritz, und Edwin Weber, Hrsg. Host Guest Complex Chemistry / Macrocycles. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70108-5.

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9

Ball, Melissa Lynne. Conjugated Macrocycles in Organic Electronics. [New York, N.Y.?]: [publisher not identified], 2019.

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Campbell, Paul James. Towards macrocycles with interactive functional groups. Birmingham: University ofBirmingham, 1994.

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Buchteile zum Thema "Macrocycles"

1

Yao, Huan, und Wei Jiang. „Naphthol-Based Macrocycles“. In Handbook of Macrocyclic Supramolecular Assembly, 975–95. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2686-2_40.

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Yao, Huan, und Wei Jiang. „Naphthol-Based Macrocycles“. In Handbook of Macrocyclic Supramolecular Assembly, 1–21. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1744-6_40-1.

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Mamedov, Vakhid A. „Synthesis of Quinoxaline Macrocycles“. In Quinoxalines, 271–342. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29773-6_5.

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Wessjohann, Ludger A., Ricardo A. W. Neves Filho, Alfredo R. Puentes und Micjel Chávez Morejón. „Macrocycles from Multicomponent Reactions“. In Practical Medicinal Chemistry with Macrocycles, 339–76. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch14.

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Masson, Géraldine, Luc Neuville, Carine Bughin, Aude Fayol und Jieping Zhu. „Multicomponent Syntheses of Macrocycles“. In Topics in Heterocyclic Chemistry, 1–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_47.

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Wessjohann, Ludger A., Ricardo A. W. Neves Filho, Alfredo R. Puentes und Micjel C. Morejon. „Macrocycles from Multicomponent Reactions“. In Multicomponent Reactions in Organic Synthesis, 231–64. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch09.

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Chio, Weng-I. Katherine, und Tung-Chun Lee. „Host–Guest Chemistry of Macrocycles“. In Macrocycle-Functionalised Nanosensors, 27–52. New York: Jenny Stanford Publishing, 2024. http://dx.doi.org/10.1201/9781003510574-2.

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Ronson, Thomas O., William P. Unsworth und Ian J. S. Fairlamb. „Palladium-Catalyzed Synthesis of Macrocycles“. In Practical Medicinal Chemistry with Macrocycles, 281–305. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch12.

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Wessjohann, Ludger A., Richard Bartelt und Wolfgang Brandt. „Natural and Nature-Inspired Macrocycles“. In Practical Medicinal Chemistry with Macrocycles, 77–100. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch4.

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Leitch, Eilidh, und Ali Tavassoli. „Macrocycles for Protein-Protein Interactions“. In Practical Medicinal Chemistry with Macrocycles, 185–204. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch8.

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Konferenzberichte zum Thema "Macrocycles"

1

Shutalev, Anatoly, Anastasia Fesenko, Dmitry Albov, Vladimir Chernyshev und Ilia Zamilatskov. „Novel 14-Membered Hexaaza Macrocycles“. In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-a042.

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Gill, Hubert S., Michael Harmjanz und Michael J. Scott. „Porphodimethenes/porphyrins: redox-switchable tetrapyrrolic macrocycles“. In Complex Adaptive Structures, herausgegeben von William B. Spillman, Jr. SPIE, 2001. http://dx.doi.org/10.1117/12.446774.

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Ortiz-Jimenez, Orlando, Mónica Trejo-Durán, Edgar Alvarado-Méndez, Israel Severiano-Carrillo und Egla Bivian-Castro. „Macrocycles in sol-gel matrix: nonlinear optical characterization“. In SPIE Nanoscience + Engineering, herausgegeben von Stefano Cabrini, Gilles Lérondel, Adam M. Schwartzberg und Taleb Mokari. SPIE, 2016. http://dx.doi.org/10.1117/12.2238228.

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Dimova, Iva. „STUDY OF STRENGTH TRAINING IN FEMALE 400 m SPRINT EVENT IN AGE ASPECT“. In INTERNATIONAL SCIENTIFIC CONGRESS “APPLIED SPORTS SCIENCES”. Scientific Publishing House NSA Press, 2022. http://dx.doi.org/10.37393/icass2022/07.

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Annotation:
ABSTRACT Studying the different aspects of 400 m sports preparation is a key factor for the proper development of sports results. Strength training is one of the main pillars of sprint running. The object of the study is sports training of athletes in the 400 m sprint, and in particular strength training. The subject is the content and volume of the annual preparation for different age groups. We used the following methods: sports-pedagogical and technical-tactical analysis of athletes; interviews with coaches and athletes; Case-study analysis; Mathematical and statistical methods. A total of 58 macrocycles were analyzed: 16 macrocycles for under 18 years, 20 macrocycles for under 20 years, 22 macrocycles for women. We made a classification of the used exercises according to the main factors of sports achievement. We found a difference in the variety of exercises applied for different age groups. Girls under 18 years have a larger set of auxiliary exercises for strength training compared to women who have less variety but increased tonnage in weight training. We established minimum, maximum and average volume values of the various means in macro-, meso- and microcycles, according to age groups. In conclusion, we can note the lack of current scientific and methodological developments related to the selection and application of a specific volume of different means during stages of sports preparation, motivated us to bring out our study and represent relevant information for the volume and diversity of used athletic means. The dynamic development of track and field preparation has to constantly update, change and improve. The study of preparation variations that are known to be successful and efficient brings valuable theoretical information that can be used in the future. Systematization of data from the practice and indication of the basic volumetric parameters of training means for strength training in the 400 m run, will help for more purposeful preparation.
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Rella, R., L. Valli und F. Chetta. „Optical sensing through wide delocalised macrocycles by SPR technique“. In Proceedings of the 6th Italian Conference. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812810779_0012.

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Leif, Robert C., Margie C. Becker, Lidia M. Vallarino, John W. Williams und Sean Yang. „Progress in the use of Quantum Dye Eu(III)-macrocycles“. In Biomedical Optics 2003, herausgegeben von Dan V. Nicolau, Joerg Enderlein, Robert C. Leif und Daniel L. Farkas. SPIE, 2003. http://dx.doi.org/10.1117/12.486324.

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Rahman, Matiur, Sougata Santra, Igor S. Kovalev, Dmitry S. Kopchuk, Grigory V. Zyryanov, Adinath Majee und Oleg N. Chupakhin. „Green synthetic approaches for practically relevant (hetero)macrocycles: An overview“. In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018078.

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Markovitch, Omer, Boris H. Kramer, Franz J. Weissing, G. Sander van Doorn und Sijbren Otto. „Competition Dynamics in a Chemical System of Self-replicating Macrocycles“. In The 2020 Conference on Artificial Life. Cambridge, MA: MIT Press, 2020. http://dx.doi.org/10.1162/isal_a_00289.

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Jaroenla, Sutee, und Amphawan Julsereewong. „Analysis of FF H1 Segment Macrocycles for Feedforward Control with Hybrid Architecture“. In 2018 15th International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology (ECTI-CON). IEEE, 2018. http://dx.doi.org/10.1109/ecticon.2018.8619991.

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Favero, Sivia, Alexander Bagger, Ruixuan Chen, Reshma Rao, Luke Higgins, James Durrant, Ifan Stephens und Magda Titirici. „Oxygen Reduction Mechanism on Fe Macrocycles: is charge transfer always coupled to adsorption?“ In Materials for Sustainable Development Conference (MAT-SUS). València: FUNDACIO DE LA COMUNITAT VALENCIANA SCITO, 2022. http://dx.doi.org/10.29363/nanoge.nfm.2022.058.

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Berichte der Organisationen zum Thema "Macrocycles"

1

van Swol, Frank B., und Craig John Medforth. Structural simulations of nanomaterials self-assembled from ionic macrocycles. Office of Scientific and Technical Information (OSTI), Oktober 2010. http://dx.doi.org/10.2172/1008138.

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Root, Harrison Duane. Applications of Porphyrinoid Macrocycles in Molecular Sensing and f-Element Coordination. Office of Scientific and Technical Information (OSTI), Juni 2020. http://dx.doi.org/10.2172/1635507.

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McKenna, Gregory, Julia Kornfield und Judit Puskas. Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), Februar 2023. http://dx.doi.org/10.2172/1971136.

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McKenna, Gregory, Julia Kornfield und Judit Puskas. Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), Februar 2023. http://dx.doi.org/10.2172/1958282.

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Puskas, Judit. Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), Februar 2023. http://dx.doi.org/10.2172/2203196.

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Allcock, Harry R. Strained Inorganic Heterocyclic Compounds and their Conversion to Macrocycles and High Polymers. Fort Belvoir, VA: Defense Technical Information Center, Oktober 1991. http://dx.doi.org/10.21236/ada241414.

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Puskas, Judit, Gregory McKenna und Julia Kornfield. Collaborative Research: Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), Juni 2019. http://dx.doi.org/10.2172/1654432.

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Eyring, Edward M., und Sergio Petrucci. Rates and Mechanisms of Complexation Reactions of Cations with Crown Ethers and Related Macrocycles. Fort Belvoir, VA: Defense Technical Information Center, Januar 1989. http://dx.doi.org/10.21236/ada203436.

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Klumpp, Doug Allen. The intramolecular cyclization of bis-2,5-dimethylene-2,5-dihydrofurans and bis-2,5-dimethylene-2,5-dihydrothiophenes: An approach to macrocycles. Office of Scientific and Technical Information (OSTI), Januar 1994. http://dx.doi.org/10.2172/10125330.

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Potts, K. Macrocyclic ligands for uranium complexation. Office of Scientific and Technical Information (OSTI), April 1990. http://dx.doi.org/10.2172/7201376.

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