Thematische Bibliographien / Long-Term efficaccy

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Auswahl der wissenschaftlichen Literatur zum Thema „Long-Term efficaccy“

Autor: Grafiati

Veröffentlicht am 14. Dezember 2024

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Zeitschriftenartikel zum Thema "Long-Term efficaccy"

Križić, Marija, Tajana Silovski, Marina Popović und Natalija Dedić Plavetić. „Abstract P4-01-39: Real-world efficaccy of dual antiHER2 therapy in first line metastatic HER2-positive breast cancer and the possibility of prediction of long-term response“. Cancer Research 83, Nr. 5_Supplement (01.03.2023): P4–01–39—P4–01–39. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-01-39.

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Abstract Background: Although huge progress has been made in treating HER2-positive metastatic breast cancer in the last decade, it remains an incurable disease. Dual anti-HER2 therapy with pertuzumab and trastuzumab combined with chemotherapy represents the standard first line treatment of metastatic HER2-positive breast cancer, in view of the impressive CLEOPATRA study results. The aim of this study was to analyze the efficacy of dual antiHER2 therapy in real-world clinical practice and determine the differences in the clinicopathological characteristics of the long-term responders in comparison with short-term responders. Methods: Retrospective analysis of dual antiHER2 therapy efficacy was done and correlated to clinical and pathological characteristics of patients with different duration of response (DoR) in the first line metastatic HER2-positive breast cancer. The study was conducted at the UHC Zagreb, Croatia and approved by the Ethics Committee. Long-term responders were defined as patients with a duration of response (DoR) to dual antiHER2 therapy ≥ 36 months, and short-term responders were defined as patients with DoR ≤ 12 months. Progression-free survival was estimated using the Kaplan-Meier method. The reverse Kaplan-Meier method was used to estimate median follow-up duration. The non-parametric Chi-Square test (between categorical variables) and Mann-Whitney U-test (between continuous variables) were used to determine the differences between long-term and short-term responders groups. The significance level was set at p < 0.05. Results: Altogether, 128 patients treated with dual antiHER2 therapy for HER2-positive metastatic breast cancer from October 2015 to May 2022 were included in the study. By data cut-off, 50.8 % (N=63) of patients had progressed or died. The median follow-up time was 36 months. The median PFS was 31 months for the total cohort (95% CI 22.6 -39.3). Overall, 29 patients among the long-term responders and 32 patients in the short-term responders group were identified. A comparison of clinical and pathological characteristics between the two groups is shown in Table 1. Even though patients in the group of long-term responders were younger (54.5 years vs. 56.5 years), had less visceral involvement (69 % vs. 81.3%), and were more often trastuzumab ”naive“ (75.9% vs. 68.7%), no statistically significant differences were found between the two groups. Conclusion: In this real-life study, the median PFS was 31 months for the total cohort, even longer than in the referent CLEOPATRA trial, which confirms the effectiveness of dual antiHER2 therapy in a real-world setting. No possible clinical or pathological predictors of long-term response were identified, but larger studies may be able to distinguish patients’ characteristics associated with long-term response. Table 1: A comparison of clinical and pathological characteristics between the group of long-term responders and short-term responders Citation Format: Marija Križić, Tajana Silovski, Marina Popović, Natalija Dedić Plavetić. Real-world efficaccy of dual antiHER2 therapy in first line metastatic HER2-positive breast cancer and the possibility of prediction of long-term response [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-01-39.

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Kubát, J., J. Klír und D. Pova. „The dry nitrogen yields nitrogen uptake, and the efficacy on nitrogen fertilisation in long-term experiment in Prague“. Plant, Soil and Environment 49, No. 8 (10.12.2011): 337–45. http://dx.doi.org/10.17221/4134-pse.

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Long-term field experiments conducted under different soil and climate conditions and their databases provide invaluable information and are indispensable means in the study of the productivity and sustainability of the soil management systems. We evaluated the results of the dry matter yields of the main products obtained with four variants of organic and mineral fertilisation in three long-term field experiments established in 1955. The experiments differed in the cultivated crops. The period of evaluation was 12 and 16 years (1985–2000), respectively. The productivity of nine-year crop rotation was lower with the fertilised variants than that with the alternative growing of spring wheat and sugar beets. The dry matter yields on the Nil variants, however, were higher in the crop rotation than in the alternate sugar beet and spring wheat growing, apparently due to the symbiotic nitrogen fixation. The dry matter yields of sugar beet and mainly of spring wheat declined in almost all variants of fertilisation in the alternate sugar beet and spring wheat growing, over the evaluated time period. In spite of the relatively high dry matter production, the declining yields indicated a lower sustainability of the alternate cropping system. Both organic and mineral fertilisation increased the production of the cultivated crops. The differences in the average dry matter yields were statistically significant. Both organic and mineral fertilisation enhanced significantly the N-uptake by the cultivated crops. The effectivity of nitrogen input was the highest with the alternate cropping of sugar beet and spring wheat indicating that it was more demanding for the external N-input and thus less sustainable than nine-year crop rotation.

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Gilchrist, Richard H., und L. Eugene Arnold. „Long-Term Efficacy of ADHD“. Psychiatric Annals 38, Nr. 1 (01.01.2008): 52–57. http://dx.doi.org/10.3928/00485713-20080101-03.

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Gilchrist, Richard H., und L. Eugene Arnold. „Long-Term Efficacy of ADHD“. Pediatric Annals 37, Nr. 1 (01.01.2008): 46–51. http://dx.doi.org/10.3928/00904481-20080101-05.

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Tanyeri, Hasan, Senol Polat, Ceyda Kirisolu und Gediz Serin. „Long-Term Efficacy of Uvulopalatopharyngoplasty“. Otolaryngology–Head and Neck Surgery 143, Nr. 2_suppl (August 2010): P50. http://dx.doi.org/10.1016/j.otohns.2010.06.040.

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JANCIN, BRUCE. „Denosumab Delivered Long-Term Efficacy“. Family Practice News 41, Nr. 17 (Oktober 2011): 16–17. http://dx.doi.org/10.1016/s0300-7073(11)70895-7.

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Lader, M. „Long-term efficacy in GAD“. European Neuropsychopharmacology 11 (Januar 2001): S160—S161. http://dx.doi.org/10.1016/s0924-977x(01)80092-4.

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Tolleth, H. „Long-term efficacy of collagen“. Aesthetic Plastic Surgery 9, Nr. 2 (Juni 1985): 155–58. http://dx.doi.org/10.1007/bf01570349.

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Kane, John. „Progress defined-short-term efficacy, long-term effectiveness“. International Clinical Psychopharmacology 16, Supplement 1 (Januar 2001): S1—S8. http://dx.doi.org/10.1097/00004850-200101001-00002.

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Q, Cai. „Long Term Paired Outcomes of Index and Redo per Oral Endoscopic Myotomy“. Gastroenterology & Hepatology International Journal 9, Nr. 1 (28.02.2024): 1–8. http://dx.doi.org/10.23880/ghij-16000214.

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Introduction: Per-Oral Endoscopic Myotomy (POEM) is a specialized procedure designed to improve symptoms by minimizing lower esophageal sphincter pressure in patients with achalasia. Despite excellent reported success rates, about 10% of patients have persistent or recurrent symptoms after procedure. There are limited studies looking at the efficacy of redo POEMS for these patients. In particular, there is no published data on comparing the paired effect of index POEM and redo POEM individually. We aimed to compare paired data of index and redo POEMs and provide election criteria for redo POEM. Methods: We conducted a retrospective observational study of all patients who underwent both index and redo POEM between August 2014 and January 2020 at Emory University. All patients underwent standard POEM protocol. We defined clinical success by an Eckardt score <3 post procedure. Results were analyzed with t tests, Chi squared tests where appropriate, or were otherwise reported as means with corresponding ranges. Results: 15 patients underwent redo POEM (ages 25-79, 53% female). One was lost to long-term follow up. There was no significant difference noted between index and redo POEM in procedure time (61.9 minutes vs. 62.2 minutes) (p=0.96), myotomy length (6.9 cm vs.6.1 cm) (p=0.13). 10 out of 15 patients (67%) achieved clinical success post-procedure with an Eckhardt score <3. Conclusion: Redo POEM procedure can be safely performed even on the same side of index POEM. Patients with previous interventions, those who clinically failed index POEM (never-responders), and those who initial responded (recurred) all can benefit from and should be offered redo POEM procedure. However, patients with severely diffusely dilated esophagus may not benefit from redo POEM and warrant surgical consultation for esophagectomy, if necessary.

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Dissertationen zum Thema "Long-Term efficaccy"

Zeineddine, Maya. „Sécurité et Efficacité à Long Terme des Thérapies Modificatrices de la Maladie à Haute Efficacité chez les Patients Atteints de Sclérose en Plaques“. Electronic Thesis or Diss., Limoges, 2024. http://www.theses.fr/2024LIMO0082.

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La sclérose en plaques (SEP) est une maladie inflammatoire chronique du système nerveux central, entraînant une invalidité significative chez les personnes atteintes. Le paysage thérapeutique de la SEP a évolué au cours des dernières décennies, avec l'introduction de diverses thérapies modificatrices de la maladie (TMM) à haute efficacité. Cette thèse examine la sécurité et l'efficacité à long terme de ces thérapies, en particulier dans le contexte de la région du Moyen-Orient et de l'Afrique du Nord (MENA). La recherche comprend une analyse approfondie de l'accessibilité aux traitements, des obstacles à la thérapie, et des résultats cliniques des patients atteints de SEP dans cette région. Elle inclut cinq études explorant la disponibilité et l'accessibilité des TMM, l'impact de la pandémie de COVID-19 sur la gestion de la SEP, et la comparaison du natalizumab avec les anticorps monoclonaux anti-CD20. Les résultats soulignent des disparités significatives dans l'accès aux traitements et la nécessité de stratégies régionales ciblées pour améliorer la prise en charge de la SEP. De plus, la recherche contribue à la compréhension mondiale de la SEP en fournissant des informations sur les résultats à long terme des TMM à haute efficacité dans un contexte réel
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system, leading to significant disability among affected individuals. The treatment landscape for MS has evolved over the past decades, with the introduction of various high-efficacy disease-modifying therapies (DMTs). This thesis investigates the long-term safety and efficacy of these therapies, particularly in the context of the Middle East and North Africa (MENA) region. The research involves a comprehensive analysis of treatment accessibility, barriers to therapy, and the clinical outcomes of MS patients in this region. It includes five studies that explore the availability and accessibility of DMTs, the impact of the COVID-19 pandemic on MS management, and the comparison of natalizumab with anti-CD20 monoclonal antibodies. The findings underscore significant disparities in treatment access and the need for targeted regional strategies to improve MS management. Furthermore, the research contributes to the global understanding of MS by providing insights into the long-term outcomes of high-efficacy DMTs in a real-world setting

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Burgess, John Robert Martin E. Davis. „Efficacy of long-term and short-term residential substance abuse treatment modalities“. Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Fall/Thesis/BURGESS_JOHN_18.pdf.

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McClure, Crystal. „Strategies for Increasing Self-Efficacy in Long-Term Welfare Recipients“. ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7824.

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With the imposition of lifetime limitations on an individual's ability to receive cash assistance, there is a group of long-term Temporary Assistance for Needy Families (TANF) recipients that have approached the lifetime limitation without becoming gainfully employed. Many long term TANF recipients report low levels of self-efficacy which inhibits their ability to successfully transition off welfare and into the workforce. However, most welfare-to-work programs do not address the emotional or psychological well-being of their clients, instead they focus on job placement and job readiness skills. The purpose of this sequential–exploratory mixed methods study is to identify the primary barriers to employment that have a negative effect on long term TANF recipient's self-efficacy. Albert Bandura's self-efficacy theory was the theoretical foundation for this study. Semi structured interviews with 20 long term TANF recipients helped answer the central research questions regarding barrier identification. The participants agreed that support for completing GED, as well as a more holistic approach to addressing their barriers is most effective in helping them transition off welfare and into the workforce. Hong's Employment Hope Scale (EHS-14) was used to collect the quantitative data for this study. The quantitative data were analyzed by multiple regression analysis and found that level of education has a statistically significant moderating effect on length of time on welfare and level of self-efficacy. This study may inform welfare-to-work providers and programmers on the importance of addressing TANF recipients' psychological needs, such as low self-efficacy before attempting to transition them into the workforce.

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Bulbulia, Richard. „Long term follow-up of the MRC/BHF Heart Protection Study : the assessment during a six year post-trial period of the effects of five years lipid-lowering therapy with simvastatin 40 mg daily and separately, antioxidant vitamin supplementation with 600 mg vitamin E, 250 mg vitamin C and 20 mg β-carotene in 17,519 surviving Heart Protection Study participants“. Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609948.

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Stotland, Stephen Charles. „Dieting self-efficacy : its relation to situational and long-term dieting success“. Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75893.

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Questionnaires were constructed to measure dieter's beliefs in their abilities to (1) adhere to a diet in eating situations, (2) perform various dieting behaviors, and (3) reach their dieting goals. The three questionnaires were called the Situation-, Behavior-, and Goal-Based Dieting Self-Efficacy Scales.
Preliminary work examined the reliability of the three scales. The Situtation-Based scale demonstrated a high level of test-retest reliability over a two to four week period in the two college samples. Examination of scale intercorrelations in the clinical sample indicated that the scales were correlated at only a low level, suggesting that the scales measure different aspects of the construct of dieting self-efficacy.
Results of the laboratory studies demonstrated that the Situation-Based scale was a significant predictor of how much dieters ate in response to two different types of challenges to their diets, high calorie preloads and a depressed mood induction.
The ability of the three scales to predict weight changes was examined in the clinical sample. Only the Goal-Based scale was found to predict weight change.
In summary, the present study adds to the body of literature supporting goal-based dieting self-efficacy as a significant predictor of weight change during dieting attempts. Suggestions were offered about ways to apply this finding to clinical practice, in the areas of patient selection and treatment prescription.
The present research was limited in the following ways. The laboratory studies were limited by the narrow range of subjects, and the artificiality of the eating situation. Future research should extend this finding with other populations, as well as methodologies for examining the relation between dieting self-efficacy and eating in real-life situations. The clinical study was limited by the absence of a follow-up assessment. Future research must examine the ability of dieting self-efficacy to predict weight change over longer periods of time. Finally, suggestions were made concerning the importance of future research attempting to clarify the construct of dieting self-efficacy, particularly research aimed at determining the relation between responses to these questionnaires and the actual cognitive processes engaged in by dieters in eating situations, and over the course of their weight control efforts. (Abstract shortened with permission of author.)

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Berish, Diane E. „INVESTIGATING THE EFFICACY OF SKILLED-NURSING FACILITIES’ TRANSITIONAL CARE PROGRAMS ON REDUCING 30-DAY HOSPITAL READMISSIONS“. Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1531907403994485.

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Alsfouk, Bshra Ali A. „Long-term efficacy and tolerability of antiepileptic drugs in newly diagnosed epilepsy patients“. Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/9104/.

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Epilepsy is the most common serious chronic neurological disorder, affecting 65 million people worldwide. Antiepileptic drugs (AEDs) constitute the main treatment for epilepsy. The introduction of 14 new AEDs over the last three decades has expanded treatment options and increased the expectations about efficacy and tolerability. However, little is known about the effectiveness of new AEDs in routine clinical practice. It is also unclear whether the treatment outcomes in epilepsy have improved in recent decades as a consequence of the availability of an increasing number of AEDs. The present work attempts to provide a comprehensive evaluation of efficacy, tolerability, and retention rate of AED treatments in everyday clinical setting. This thesis is divided into six chapters, three general chapters and three result chapters (Chapter 3, 4, and 5). Chapter 1 sorts out the background of epilepsy, pharmacological management, and adverse drug reactions. The new classification of seizures and epilepsies, AED therapy, and guidelines for initiation, selection and dosing of AEDs are described. Followed by discussion of clinically relevant adverse effects of AEDs. Chapter 2 describes the study population and definition of outcome measures. Data collection and statistical analysis were presented as well. The data of this study were extracted retrospectively by reviewing the patients’ medical records. The patients were first diagnosed with epilepsy and prescribed AED treatment at the Glasgow Epilepsy Unit between Jul 1982 and Oct 2012; then they were prospectively followed up until 30 Apr 2016 with at least one year follow-up after starting AEDs therapy. The study cohort included 1,528 patients aged 18 to 93 years (median 37), 849 (56%) were men, and 1,290 (84%) had focal epilepsy. Chapter 3 evaluates efficacy of AEDs and the changes in treatment outcomes of epilepsy over the past 30 years. This was achieved by comparing the results of current analysis to the results of three analyses conducted in 1999, 2003, and 2008 on same expanding cohort (n=470, 890, and 1,098 respectively) from the Epilepsy Unit in Glasgow. The overall efficacy rate of AEDs in this study was 62% (n=941/1,528); this was comparable to what was observed in the previous analysis of 17 years ago on the same expanding cohort in which 64% (n=301/470) of newly diagnosed epilepsy patients achieved seizure-free. Likewise, the efficacy rates of different established and new AEDs were comparable. Therefore, this provides a strong evidence that treatment outcomes in epilepsy have not improved in recent decades despite the availability of increasing number of AEDs. However, the results indicated that the use of new AEDs has increased, 41% of patients continued to take the new AEDs as a monotherapy in the current study, compared to 26% in 1999. This most likely due to their advantages in terms of tolerability. This analysis also found that family history of epilepsy, more than ten pre-treatment seizures, psychiatric conditions, alcohol and recreational drugs abuse, and failure to response to two or more AEDs were significantly associated with poor seizure outcomes. In Chapter 4, the rate and predictors of intolerable adverse effects of AEDs were assessed. This study showed that 28% (n=815/2,911) of total AEDs prescriptions were discontinued because of poor tolerability. In which the most frequent problem was tiredness (5.2%, n=152/2,911) followed by poor coordination and rash, with a 2.9% (n=86) incidence for each. Among 17 different AEDs, lamotrigine was associated with the best tolerability whether it was used as monotherapy (19%, n=109/575) or as part of polytherapy (9%, n=35/387). While topiramate was associated with the highest rate of adverse effects (39%, n=32/81) among monotherapies, and retigabine had the highest rate of adverse effects (42%, n=8/19) among AEDs used as part of polytherapy. Moreover, each AED demonstrated a distinct tolerability profile; the main intolerable adverse reaction associated with lamotrigine and carbamazepine was skin rash while valproate was poorly tolerated most frequently due to tremor and weight gain. Furthermore, levetiracetam was poorly tolerated commonly due to psychiatric and behavioural side effects whereas cognitive dysfunction was the most common reason for topiramate intolerability. Beside individual AED, poor tolerability was related to patient’s susceptibility and number of co-prescribed AEDs. Prior intolerable AEDs schedule was associated with high probability to experience intolerable adverse effects at subsequent AED schedule. Likewise, female, focal epilepsy, more than ten pre-treatment seizures, and psychiatric comorbidity were significantly associated with higher rates of adverse effects. However, older AEDs usage was not significantly associated with poorer tolerability. These may present novel findings from this study as very few studies have evaluated the predictors for poor tolerability particularly non-AEDs variables. In Chapter 5, a survival analysis was performed to identify retention rates (time to discontinuation) of lamotrigine, valproate, carbamazepine, and levetiracetam monotherapies. Lamotrigine showed the highest retention rate, with median duration of therapy of 84 months. This was significantly higher than the retention times of valproate (42 months), carbamazepine (36 months), and levetiracetam (36 months); there was no significant difference in retention rates of other AEDs. However, within six months of therapy initiation, lamotrigine and carbamazepine demonstrated the highest discontinuation rates, most probably due to rash. Few observational studies have investigated the long-term retention rates of AEDs in the UK. Therefore, the current research may present novel findings in term of population as well. In Chapter 6, study strengths and limitations are presented. Clinical implications and the future directions of research in epilepsy are described as well.

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Kent, Lisa. „Practicing Self-Efficacy and Transparency to Achieve Long-Term Recovery and Reduce Recidivism“. ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7397.

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There is limited data about the positive application of self-efficacy and the practice of transparency for individuals in recovery to achieve long-term recovery from substance addiction and criminal recidivism. The purpose of this qualitative phenomenological study was to gain more insight and knowledge about how the application of self-efficacy and the practice of transparency help individuals in recovery achieve long-term recovery from substance addiction and criminal recidivism for two or more years. The conceptual framework used to guide this study was Albert Bandura's self-efficacy theory. This study is significant because it explains that long-term recovery is not an easy task to achieve, and many individuals who have a history of addiction and criminal behavior find it extremely difficult to achieve long-term recovery. A qualitative phenomenological approach was used for this study. This study employed a chain sample, using a semi-structured interview guide composed of open-ended questions. Five individuals agreed to the study and reported applying and practicing self-efficacy and transparency to achieve long-term recovery. The study analyzed and coded data to identify categories and themes. The findings reveled the importance of the use of self-efficacy and transparency in achieving long-term recovery from substances and decreasing recidivism. Themes identified was the ability to live day-to-day, breaking the cycle of addiction and recidivism, believing they are worth recovery (a better life), and sharing their story (transparency). This study may stimulate positive social change with the application of self-efficacy, as people struggling with addiction and recidivism may learn the importance of being transparent during the recovery process.

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Woensel, Jacobus Bernardus Maria van. „Lower respiratory tract infection caused by respiratory syncytial virus the short-term and long-term efficacy of corticosteroids /“. [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/63898.

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Kotrappa, Neel. „The Efficacy of Long-Term Kinesio Tape on Grip Strength in a Healthy Population“. Scholarship @ Claremont, 2014. http://scholarship.claremont.edu/cmc_theses/976.

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Kinesio® Tape was invented in 1973, and since has been used in various clinical and therapy settings to prevent and heal a multitude of physical conditions. Kinesio® Tape is a 100% cotton-based elastic tape that when applied to the skin pulls the skin upwards and creates more space by lifting the fascia and soft tissue, thus increasing blood flow and decreasing edema. The tape was also purported to facilitate the strengthening of weakened muscles through neuromuscular facilitation. The objective behind this study was to determine the long-term effects of applied forearm Kinesio® Tape on maximal grip strength when paired with an exercise program. The study took place at the CMS Athletic Training Center, and was designed to be a matched-pairs, single group, repeated measures experiment. Thirty- two healthy members of the Claremont College community voluntarily participated in this study. There was 16 male and 16 female participants (average age: 21.46 ± 1.76 years; average height 174.92 ± 9.40 cm; average body weight 69.17 ± 9.20 kg). The maximal grip strength of both the dominant and non-dominant hands was measured using a JAMAR Hydraulic Hand Dynamometer. Each of the 32 subjects also participated in an exercise program for two weeks and provided a grip strength measurement at the end of each week. Maximal grip strength values were assessed using a standard paired-samples t-test. Results revealed a significant difference in grip strength in the dominant arm (exercise with Kinesio® Tape) compared to the non-dominant arm (exercise only). When combined with a relatively low to medium level exercise program, Kinesio® Tape significantly increased grip strength when compared to an exercise program alone in a healthy population.

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Bücher zum Thema "Long-Term efficaccy"

Braddock, Kathleen. Electroconvulsive Therapy: Clinical Uses, Efficacy and Long-Term Health Effects. Nova Science Publishers, Incorporated, 2014.

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Tucker, Sharon Joann. THE LONG-TERM EFFICACY OF A BEHAVIORAL PARENT TRAINING INTERVENTION FOR FAMILIES WITH TWO-YEAR-OLDS. 1996.

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Sayal, Puneet, und Jianren Mao. Opioids in Spine Pain: Indications, Challenges, and Controversies. Herausgegeben von Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0029.

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Opioid medications are commonly used in the treatment of spine-mediated pain. They are used on a chronic, long-term basis, and their use is on the rise. The available evidence supports their use for short periods if much effort is put into patient and opioid selection, and with close monitoring. Challenges include numerous adverse effects, aberrant behaviors, and the comfort and skill set of providers. Controversies surrounding the chronic use of opioids center on the inconclusive evidence regarding long-term efficacy and safety. More research is necessary to determine whether these medications are appropriate, efficacious, and safe over the long term, and also to aid providers in managing patients on chronic opioids in terms of patient and opioid selection, risk stratification, monitoring, and discontinuation/weaning.

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Castle, David J., Peter F. Buckley und Fiona P. Gaughran. Effects of antipsychotic medications on physical health. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198811688.003.0006.

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Antipsychotic medications are a crucial part of the core platform upon which effective treatments for schizophrenia are built. While the marketed agents have established efficacy for reduction in the symptoms of schizophrenia, they all carry some side effects. Such effects differ across medications and between individuals. Prescribers need to be aware of the side effect profile of the medications they use, and ensure patients are also aware, so that a true shared decision-making model can be followed in terms of medication choice. Appreciation of long-term risk is required, with treatment choice in the short term having a view to the long term.

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Lam, Raymond W. Somatic treatments. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199692736.003.0008.

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• Wake therapy, exercise and light therapy are non-invasive and clinically useful treatments.• Electroconvulsive therapy remains an effective, safe and well-tolerated treatment for patients with severe, psychotic or medication-resistant depression.• Repetitive transcranial magnetic stimulation is an emerging treatment with evidence for acute efficacy, but with limited data about long-term management....

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Hoffman, Ralph E., und Arielle D. Stanford. TMS clinical trials involving patients with schizophrenia. Herausgegeben von Charles M. Epstein, Eric M. Wassermann und Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0042.

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Repetitive transcranial magnetic stimulation ((r)TMS) is being studied as an experimental intervention for patients with neuropsychiatric disorders. These approaches have been informed by animal studies of long-term potentiation (LTP) and long-term depression (LTD). They show that repeated stimulation of neural circuits could exert effects on synaptic efficacy, for varying amounts of time, beyond the period of stimulation. Few studies using rTMS as a potential clinical intervention for schizophrenia have been carried out. They show promise in terms of advancing the understanding of pathophysiological mechanisms and developing alternative interventions. These studies, considered together, suggest that rTMS holds promise as an intervention strategy for patients with schizophrenia. Rigorously designed trials with larger numbers of subjects are indicated in order to take into account nonspecific factors that could add noise to outcome data.

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Valeriano, Brandon. Introduction. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190618094.003.0001.

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This chapter evaluates the efficacy of modern cyber strategies and how states coerce rivals in the digital domain. It argues that these campaigns are neither as revolutionary nor as novel as they seem. It finds that cyber disruptions, short-term and long-term espionage, and degradation operations all usually fail to produce concessions. When states do compel a rival, which is measured as a change in behavior in the target that is strategically advantageous to the initiator, the cyber operation tends to occur alongside more traditional coercive instruments such as diplomatic pressure, economic sanctions, and military threats and displays. Cyber capabilities complement, but do not replace traditional statecraft. Theoretical and empirical investigation of cyber strategies and their efficacy should therefore precede development of suggestions for sound foreign policy responses to state-backed cyber intrusions or craft international frameworks that constrain the proliferation of politically motivated malware. This book is a critical first step.

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Chan, Jonathan, und Nigil Haroon. Treatment: NSAIDs. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0020.

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Non-steroidal anti-inflammatory drugs (NSAIDs) constitute a diverse group of medications that inhibit prostaglandin synthesis. NSAIDs form the first-line pharmacological therapy in ankylosing spondylitis (AS). A number of randomized controlled trials (RCTs) support the efficacy of NSAIDs in reducing pain and improving patient function. Head-to-head comparisons have demonstrated equivalent effect of different NSAIDs in symptom control. The proposed disease-modifying potential of regular NSAID therapy is debatable and recent literature provides evidence to the contrary. Several safety concerns have been raised regarding long-term use of NSAIDs, especially an increase in cardiovascular risk. This chapter discusses the pharmacology, efficacy in treatment of AS, disease-modifying potential, and safety concerns of NSAIDs.

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Kass, Erica, Jonathan E. Posner und Laurence L. Greenhill. Pharmacological Treatments for Attention-Deficit/Hyperactivity Disorder and Disruptive Behavior Disorders. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0004.

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More than 225 placebo-controlled type 1 investigations demonstrate that psychostimulants are highly effective in reducing core symptoms of attention-deficit/hyperactivity disorder (ADHD) in children and adults. In contrast, there are limited type I studies demonstrating that psychopharmacological management with U.S. Food & Drug Administration-approved agents for ADHD (stimulants and nonstimulants), atypical antipsychotics, and mood stabilizers decrease the defiant and aggressive behavior characteristic of disruptive behavior disorders. Stimulant treatment evidence has been supplemented by two large multisite randomized controlled trials. Randomized controlled trials from the past 15 years continue to report several key adverse events associated with stimulants but have not supported rarer and more serious problems. Although psychostimulants have been shown to retain their efficacy for as long as 14 months, their long-term academic and social benefits are not as robust. Nonstimulant agents for which there is more limited evidence of efficacy include atomoxetine, alpha-agonists, modafinil, and bupropion.

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Davidson, Judy E., und Giora Netzer. Family Response to Critical Illness. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199398690.003.0008.

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Family members of ICU patients can have mental, physical, and social responses to critical illness. These responses can begin when their loved ones are in the ICU and persist after discharge. Interventions in the ICU could have long-term effects on family members. Communication, proximity, engagement, maintaining family integrity, optimizing sleep, and conflict resolution may all play a role in family health following the discharge or death of the patient. Research is needed to further quantify the epidemiology, mechanisms of action, and efficacy of interventions to optimize the health of this large group of people. While waiting for research results to definitively point us towards effective preventive measures and early interventions, it is prudent to optimize communication, encourage proximity and engagement, and support the health of family members while caring for the critically ill and injured. As patients and their families move into the home environment, it is important to consider their long-term health as well.

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Buchteile zum Thema "Long-Term efficaccy"

Ratti, Pietro-Luca. „Long-Term Efficacy of Pharmacological Treatment“. In Restless Legs Syndrome/Willis Ekbom Disease, 141–54. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6777-3_11.

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Kadoya, Yoshihiko. „Verifying the implementation effects (efficacy) of the care market model“. In Human Services and Long-term Care, 54–75. Abingdon, Oxon ; New York, NY : Routledge, 2018. | Series: Routledge studies in the modern world economy ; 175: Routledge, 2018. http://dx.doi.org/10.4324/9781315209159-5.

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Pennisi, Marzio, Dario Motta, Alessandro Cincotti und Francesco Pappalardo. „Predicting Long-Term Vaccine Efficacy against Metastases Using Agents“. In Bio-Inspired Computing and Applications, 97–106. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-24553-4_15.

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Kane, Robert L. „Meeting Long-Term-Care Needs: Efficacy, Efficiency, and Affordability“. In Aging 2000: Our Health Care Destiny, 259–65. New York, NY: Springer New York, 1985. http://dx.doi.org/10.1007/978-1-4612-5062-3_23.

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Papapoulos, Socrates E. „Long-Term Efficacy and Safety of Treatments for Osteoporosis“. In The Duration and Safety of Osteoporosis Treatment, 203–32. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23639-1_15.

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Berger, M. „Long-Term Efficacy and Safety of Intensified Insulin Treatment Strategies“. In Bayer AG Centenary Symposium, 225–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74255-2_19.

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Fiegenbaum, W. „Long-Term Efficacy of Ungraded Versus Graded Massed Exposure in Agoraphobics“. In Panic and Phobias 2, 83–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73543-1_8.

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Calkins, Hugh, Emanuele Bertaglia, Antonio Berruezo, Aldo Bonso, Jonathan M. Kalman, Moussa Mansour und Atul Verma. „Short- and Long-Term Efficacy of Catheter Ablation Procedures for Atrial fibrillation“. In Atrial Fibrillation Ablation, 2011 Update, 118–26. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781119963868.ch8.

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Jabbari, Bahman. „Why Neurotoxin Treatment is Generally Safe? What is the Long-Term Efficacy“. In Botulinum Toxin Treatment, 181–92. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99945-6_15.

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Mäki-Ikola, Outi, Esa Heinonen und Risto Lammintausta. „Long-Term Safety and Efficacy of Selegiline in the Treatment of Parkinson’s Disease“. In Neurochemistry, 331–37. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5405-9_56.

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Konferenzberichte zum Thema "Long-Term efficaccy"

VGONTZAS, ALEXANDROS N., ERNEST MANDERS, EDWARD O. BIXLER, ROCCO L. MANFREDI, ANTONIO VELA-BUENO und ANTHONY KALES. „LONG-TERM EFFICACY OF UVULOPALATOPHARYNGOPLASTY FOR SLEEP APNEA“. In IX World Congress of Psychiatry. WORLD SCIENTIFIC, 1994. http://dx.doi.org/10.1142/9789814440912_0176.

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Kammerer, Susanne. „Robust long-term efficacy of bimekizumab in psoriasis“. In 2024 AAD Annual Meeting, herausgegeben von Peter van de Kerkhof. Baarn, the Netherlands: Medicom Medical Publishers, 2024. http://dx.doi.org/10.55788/50445052.

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Wijsman, P. C., A. W. Goorsenberg, J. N. D' Hooghe, N. H. Ten Hacken, E. J. Weersink, E. H. Bel, P. L. Shah, J. T. Annema und P. I. Bonta. „Bronchial thermoplasty; its long-term efficacy in severe asthma“. In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2014.

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Danese, Silvio, und Susanne Kammerer. „Continued efficacy of long-term ozanimod as UC treatment“. In ECCO 2023, herausgegeben von Silvio Danese und Marjolijn Duijvestein. Baarn, the Netherlands: Medicom Medical Publishers, 2023. http://dx.doi.org/10.55788/9d2ded57.

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van den Heuvel, Robert. „Can ritlecitinib deliver long-term efficacy in alopecia areata?“ In 25th World Congress of Dermatology, herausgegeben von Peter van de Kerkhof. Baarn, the Netherlands: Medicom Medical Publishers, 2023. http://dx.doi.org/10.55788/de921e89.

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Kammerer, Susanne. „JAK1 inhibitor shows promising long-term efficacy in PN“. In EADV Congress 2024, herausgegeben von Peter van de Kerkhof. Baarn, the Netherlands: Medicom Medical Publishers, 2024. http://dx.doi.org/10.55788/ebed633c.

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Bennett, Jeffrey, und Michiel Tent. „Sustained long-term efficacy and safety of satralizumab in NMOSD“. In 2022 Annual Meeting American Academy of Neurology, herausgegeben von Hans-Peter Hartung. Baarn, the Netherlands: Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/a9e7d8cd.

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Arum, Carl-Jørgen, Camilla Muller, Pal Romundstad, Inger Stokkan und Jan Mjønes. „Long-term therapeutic efficacy of photo-selective vaporization of prostate“. In BiOS, herausgegeben von Nikiforos Kollias, Bernard Choi, Haishan Zeng, Reza S. Malek, Brian J. Wong, Justus F. R. Ilgner, Kenton W. Gregory et al. SPIE, 2010. http://dx.doi.org/10.1117/12.842165.

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Gordon, Kenneth, und Kenneth Gordon. „Long-term psoriasis treatment with bimekizumab results in maintained efficacy“. In 2022 American Academy of Dermatology Annual Meeting, herausgegeben von Peter van de Kerkhof. Baarn, the Netherlands: Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/dac5bb0b.

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Berichte der Organisationen zum Thema "Long-Term efficaccy"

Tsodikov, Alexander. Short- and Long-Term Effects in Prostate Cancer Survival: Analysis of Treatment Efficacy and Risk Prediction. Fort Belvoir, VA: Defense Technical Information Center, März 2005. http://dx.doi.org/10.21236/ada437726.

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Tsodikov, Alexander D. Short- and Long-Term Effects in Prostate Cancer Survival: Analysis of Treatment Efficacy and Risk Prediction. Fort Belvoir, VA: Defense Technical Information Center, März 2006. http://dx.doi.org/10.21236/ada455402.

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li, liqing, qiaoyuan wu, tingshi su, zhitao lin und shixiong liang. Can Stereotactic Body Radiotherapy Provide Long Term Efficacy for Small Hepatocellular Carcinoma? — A Network Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0060.

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Bridges, Todd, Sandra Newell, Alan Kennedy, David Moore, Upal Ghosh, Trevor Needham, Huan Xia, Kibeum Kim, Charles Menzie und Konrad Kulacki. Long-term stability and efficacy of historic activated carbon (AC) deployments at diverse freshwater and marine remediation sites. Engineer Research and Development Center (U.S.), November 2020. http://dx.doi.org/10.21079/11681/38781.

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A number of sites around the United States have used activated carbon (AC) amendments to remedy contaminated sediments. Variation in site-specific characteristics likely influences the long-term fate and efficacy of AC treatment. The long-term effectiveness of an AC amendment to sediment is largely unknown, as the field performance has not been monitored for more than three years. As a consequence, the focus of this research effort was to evaluate AC’s long-term (6–10 yr) performance. These assessments were performed at two pilot-scale demonstration sites, Grasse River, Massena, New York and Canal Creek, Aberdeen Proving Ground (APG), Aberdeen, Maryland, representing two distinct physical environments. Sediment core samples were collected after 6 and 10 years of remedy implementation at APG and Grasse River, respectively. Core samples were collected and sectioned to determine the current vertical distribution and persistence of AC in the field. The concentration profile of polychlorinated biphenyls (PCBs) in sediment pore water with depth was measured using passive sampling. Sediment samples from the untreated and AC-treated zones were also assessed for bioaccumulation in benthic organisms. The data collected enabled comparison of AC distribution, PCB concentrations, and bioaccumulation measured over the short- and long-term (months to years).

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Sun, Xiaoxi, und lihong Ma. Efficacy and safety of long-term Baduanjin exercise in patients with chronic heart failure: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, März 2024. http://dx.doi.org/10.37766/inplasy2024.3.0099.

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Wang, He, Jun Chen, Xiaoling Wang und Jun Dang. Neoadjuvant immune checkpoint inhibitor in combination with chemotherapy or chemoradiotherapy in resectable esophageal cancer: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Juni 2022. http://dx.doi.org/10.37766/inplasy2022.6.0052.

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Review question / Objective: It remains unclear whether addition of immune checkpoint inhibitor (ICI) to neoadjuvant chemoradiotherapy (nCRT) or neoadjuvant chemotherapy (nCT) can increase antitumor efficacy in resectable esophageal cancer (EC). we performed the systematic review and meta-analysis to assess antitumor efficacy and safety of nICRT and nICT, and made a comparison with nCRT and nICT. We used pathological complete response (pCR) as the primary outcomes of interest. Condition being studied: Initial findings from a number of phase 1 or 2 trials have supported the tolerability and/or antitumor efficacy of ICI plus nICRT (nICRT) and nICT (nICT). However, the superiority of this combination strategy remains uncertain due to lack of randomized control trials (RCTs) with long-term outcomes. Moreover, there are still outstanding questions such as the selection of nICRT or nICT, the ideal predictive biomarkers, and timing of surgical resection.

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Li, Sihui, Weishang Hu und Qiaofeng Wu. The long-term efficacy comparison of five external treatments of Traditional Chinese Medicine on knee osteoarthritis: a protocol for network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Juli 2020. http://dx.doi.org/10.37766/inplasy2020.7.0122.

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Wang, Shihao, Jiyan Tang, Weipeng Sun, Hongyu Yao und Zhen Li. The Natural Orifice Specimen Extraction Surgery Compared With Conventional Laparoscopy for Colorectal Cancer: A Meta-analysis of Efficacy and Long-term oncological Outcomes. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Juli 2021. http://dx.doi.org/10.37766/inplasy2021.7.0055.

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Ye, Guancheng, Qiuyi Li, Jiaqi Chen, Fenglan Pu, Chunyan Zhang, Jie Li und Guiying Peng. Long-term efficacy of biological agents in the treatment of interstitial lung disease associated with connective tissue disease: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Oktober 2022. http://dx.doi.org/10.37766/inplasy2022.10.0027.

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