Auswahl der wissenschaftlichen Literatur zum Thema „Lipid transporters“
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Zeitschriftenartikel zum Thema "Lipid transporters"
Hilgemann, Donald W., Gucan Dai, Anthony Collins, Vincenzo Larricia, Simona Magi, Christine Deisl und Michael Fine. „Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis“. Journal of General Physiology 150, Nr. 2 (11.01.2018): 211–24. http://dx.doi.org/10.1085/jgp.201711875.
Der volle Inhalt der QuelleDionysopoulou, Mariangela, und George Diallinas. „Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in Aspergillus nidulans“. Journal of Fungi 7, Nr. 7 (28.06.2021): 514. http://dx.doi.org/10.3390/jof7070514.
Der volle Inhalt der QuelleChen, Ru, Yasuyo Yamaoka, Yanbin Feng, Zhanyou Chi, Song Xue und Fantao Kong. „Co-Expression of Lipid Transporters Simultaneously Enhances Oil and Starch Accumulation in the Green Microalga Chlamydomonas reinhardtii under Nitrogen Starvation“. Metabolites 13, Nr. 1 (10.01.2023): 115. http://dx.doi.org/10.3390/metabo13010115.
Der volle Inhalt der QuelleLangmann, Thomas, Richard Mauerer und Gerd Schmitz. „Human ATP-Binding Cassette Transporter TaqMan Low-Density Array: Analysis of Macrophage Differentiation and Foam Cell Formation“. Clinical Chemistry 52, Nr. 2 (01.02.2006): 310–13. http://dx.doi.org/10.1373/clinchem.2005.059774.
Der volle Inhalt der QuelleNagahashi, Masayuki, Kazuaki Takabe, Krista P. Terracina, Daiki Soma, Yuki Hirose, Takashi Kobayashi, Yasunobu Matsuda und Toshifumi Wakai. „Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy“. BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/651727.
Der volle Inhalt der QuelleMcKinlay, Colin J., Nancy L. Benner, Ole A. Haabeth, Robert M. Waymouth und Paul A. Wender. „Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters“. Proceedings of the National Academy of Sciences 115, Nr. 26 (11.06.2018): E5859—E5866. http://dx.doi.org/10.1073/pnas.1805358115.
Der volle Inhalt der QuelleKotlyarov, Stanislav, und Anna Kotlyarova. „The Role of ABC Transporters in Lipid Metabolism and the Comorbid Course of Chronic Obstructive Pulmonary Disease and Atherosclerosis“. International Journal of Molecular Sciences 22, Nr. 13 (23.06.2021): 6711. http://dx.doi.org/10.3390/ijms22136711.
Der volle Inhalt der QuelleKok, Jan Willem, Karin Klappe und Ina Hummel. „The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter“. Advances in Biology 2014 (05.05.2014): 1–11. http://dx.doi.org/10.1155/2014/105898.
Der volle Inhalt der QuelleKotlyarov, S. N., und A. A. Kotlyarova. „Participation of ABC-transporters in lipid metabolism and pathogenesis of atherosclerosis“. Genes & Cells 15, Nr. 3 (15.09.2020): 22–28. http://dx.doi.org/10.23868/202011003.
Der volle Inhalt der QuelleJedlitschky, Gabriele, Andreas Greinacher und Heyo K. Kroemer. „Transporters in human platelets: physiologic function and impact for pharmacotherapy“. Blood 119, Nr. 15 (12.04.2012): 3394–402. http://dx.doi.org/10.1182/blood-2011-09-336933.
Der volle Inhalt der QuelleDissertationen zum Thema "Lipid transporters"
Raggers, René John. „Lipid translocation by multidrug transporters“. [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/60218.
Der volle Inhalt der QuelleAlrosan, Amjad. „Characterization of Interacting Partners of ABC Lipid Transporters“. Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/22999.
Der volle Inhalt der QuelleCharalambous, Kalypso Nicola. „The effect of lipid bilayer composition on small multidrug resistance transporters“. Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432740.
Der volle Inhalt der QuelleWei, Liang Shen. „Drug and lipid interactions on the ABC transporters ABCG1 and MsbA“. Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609340.
Der volle Inhalt der QuelleFrangos, Zachary Joseph. „Investigating the molecular mechanism of bioactive lipid inhibitors of GlyT2“. Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28029.
Der volle Inhalt der QuelleAleidi, Shereen Mohammad Suleimann. „Characterization of the Post-Translational Regulation of the ABCA1 and ABCG1 Lipid Transporters by E3 Ligases“. Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15477.
Der volle Inhalt der QuelleChantemargue, Benjamin. „In silico investigation of xenobiotic interactions with lipid bilayers and ABC membrane transporters, the case of ABCC4/MRP4“. Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0077/document.
Der volle Inhalt der QuelleUnderstanding the biological mechanisms of action of membrane proteins requires the comprehension of the interactions of xenobiotics with these proteins and with lipid membranes. Experimental methods are often demanding and only partially respond to xenobiotic-membrane-protein interactions. In silico molecular modeling is a serious alternative to tackle these issues. Molecular dynamics (MD) and biased dynamics simulations have opened many perspectives by providing an atomistic description of these intermolecular interactions. Using MD simulations, we built a model of the human ABC ABCC4/MRP4 transporter. We explored the influence of cholesterol on this protein as well as the impact of a polymorphism known to shut down the transport activity of this protein. We also studied the interaction of xenobiotics with this human transporter. The transport cycle of the ABC transporters was investigated in an attempt to better understand how it works.Interactions between lipid membranes and xenobiotics were explored by examining their ability to incorporate lipid membranes. Lipid mixtures with cholesterol showed a significant impact on the human protein ABCC4/MRP4 and on the xenobiotics studied. The importance of regions, domains constituting the ABCC4/MRP4 protein as well as the importance of specific residues has been clearly demonstrated. We also observed intermediates in the transport cycle of an ABC transporter in conjunction with structural changes occurring during this cycle
Basante-Bedoya, Miguel Angel. „Transporteurs lipidiques dans la morphogenèse du champignon pathogène opportuniste de l’Homme Candida albicans“. Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6030.
Der volle Inhalt der QuelleCandida albicans is a human opportunistic fungal pathogen that can cause superficial or systemic infections; its ability to change from an ovoid to a filamentous form is associated with its virulence. During this highly polarized filamentous growth, an accumulation of vesicles (Spitzenkörper), characteristic of filamentous fungi, as well as a polarized distribution of lipids, such as ergosterol, phosphorylated derivatives of phosphatidylinositol (PI(4)P, PI(4,5)P2) and phosphatidylserine (PS) is observed at the apex of filaments. However, the importance of the asymmetry of these lipids in the membrane bilayer is not completely understood. Flippases (P4-ATPases) transport lipids across the membrane bilayer to generate and maintain its asymmetry. C. albicans has 5 flippases, including Drs2 which is critical for filamentous growth and phosphatidylserine (PS) distribution. Furthermore, a drs2 deletion mutant is hypersensitive to fluconazole and copper. We show here that such a mutant is also critical to virulence in a mouse model of systemic infection. To clarify the role of Drs2 during C. albicans filamentous growth, we studied the distribution of this ATPase, as well as that of key lipids and regulators, during the initiation and maintenance of this growth process. We also characterized point mutants of Drs2, analogous to those altered for PS transport in S. cerevisiae. In addition, we examined the importance of other flippases, such as Dnf1-3, in invasive growth and the role of lipid transporters belonging to the oxysterol binding protein (Osh) family. Our results indicate in particular that Drs2 plays a unique role in the maintenance of invasive filamentous growth of C. albicans, which appears to be more critical after the first septum formation, and that an interaction between Drs2 and Osh4, via PI(4)P, plays an essential role during invasive filamentous growth
Lacabanne, Denis. „Solid-state NMR studies of the ABC transporter BmrA in its lipid environment“. Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1243/document.
Der volle Inhalt der QuelleATP binding cassette (ABC) transporters can translocate a variety of molecules by coupling drug/lipid efflux with an ATP-Mg2+ fuelled engine. They are found in all forms of life and they are involved in a number of drug resistances including anti-cancer drugs and antibiotics. My studies focus on the drug exporter BmrA (130 kDa) from Bacillus subtilis as a model system and homologue of the human P-glycoprotein that is involved in multidrug resistance in cancer. We show that the reconstitution of this protein in lipids from Bacillus subtilis at a lipid-protein ratio of 0.5 m/m allows an optimal protein insertion into lipid bilayer as well as it complies with the two central NMR requirements: high signal-to-noise in the spectra and sample stability over a time period of years. The obtained spectra point to a well-folded protein and a highly homogenous preparation, as witnessed by the narrow resonance lines and the signal dispersion typical of the expected secondary structure distribution of the membrane protein. In the same time, we adapted the GRecon method used in electron microscopy studies for membrane protein reconstitution to the needs of solid-state NMR sample preparation. We followed in detail the reconstitution of the ABC transporter BmrA by dialysis as a reference, and established optimal reconstitution conditions using the combined sucrose/cyclodextrin/lipid gradient characterizing GRecon. NMR spectra recorded on a sample produced by GRecon showed a highly similar fingerprint as those recorded previously on samples reconstituted by dialysis. GRecon sample preparation presents a gain in time of nearly an order of magnitude for reconstitution. In order to study the inward-facing (IF) and the outward-facing (OF) state of the transporter, we developed a reproducible and quantitative protocol of ATP:Mg2+:VO43- addition inducing the OF state. We used selectively labelled samples obtained by the addition of natural abundance residues in the bacterial medium in order to reduce the number of signals in the spectra of this large protein. We recorded solid-state NMR two-dimensional spectra with different mixing times (20 and 200 ms) in order to follow chemical shift changes and identify residues by sequential correlations. The very noticeable apparition of new signals concomitant with the large amplitude of chemical shift perturbations (CSPs) highlight the important flexibility and conformational changes of the protein in presence of ATP:Mg2+:VO43- substrate. In order to identify the residues appearing in the spectra, we use paramagnetic replacement by Mn2+ of the Mg2+ acting as a co-factor in the active site. The paramagnetic relaxation enhancements caused the Mn2+ revealed that the amino acids appearing in the spectra are located in proximity to the ATP binding pocket. Besides, EPR measurements confirmed the closed state of the protein by identifying the corresponding 1.8 nm distances between two Mn2+. We investigate on the conformational differences identified between the IF and OF state in the ABC transporter BmrA reconstituted in its natural lipids. The observation of numerous CSPs, as well as the apparition new signals are observed for a hydrolysis-incompetent mutant on addition of ATP, indicating that hydrolysis is not required for the IF to OF transition in BmrA. We also analyze the mechanistic of the X-loop motif described to be involved in the communication between two domains of the protein. We observe for a mutant protein in which transport is abolished, but which remains ATPase active, an incomplete transition since only a subset of CSPs is observed, as well as lack of rigidification. This suggests that the change in dynamics might be central for transmitting the relevant conformational changes to the part of the protein driving transport, concomitant of an engine which is turning an input shaft, but which fails to connect in a rigid manner, trough adequate gears, with the output shaft driving the pump
Mathey, Aline. „Nouvelles stratégies thérapeutiques et chimiorésistance : molécules bioactives et métabolisme lipidique“. Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCI014.
Der volle Inhalt der QuelleMany therapeutic failures persist due to adaptation and tumor resistance mechanisms, such as insensitivity to cell death signals, the overexpression of drug efflux transporters (i.e. ABC transporters involved in the multidrug resistance phenotype or MDR), mutations in DNA damage detection and repair pathways or reprogramming of energy metabolism. More specifically, an increasing number of studies suggest that deregulations of mitochondrial lipid metabolism, cardiolipins, play a role in tumor progression and aggressiveness, thereby representing an attractive therapeutic target in recent years. As a result, new innovative therapeutic protocols based on the use of bioactive molecules of low toxicity have appeared in order to overcome chemoresistance, reduce toxicity, side effects and potentiate the effectiveness of the chemotherapeutic drug in order to extend the life expectancy and enhance the quality of life of patients. Concerning the first part of this project, we demonstrated for the first time the ability of xanthohumol, a prenylated flavonoid extracted from hops, to restore the induction of DNA damage in colorectal cancer cells and to sensitize the latter to a commonly used clinically anticancer agent, SN38. We have also shown the ability of two essential oils extracted from Apiaceae in Tunisia, Pituranthos chloranthus and Teucrium ramosissimum, to restore the sensitivity of uterine sarcoma cells presenting the MDR phenotype, in particular to doxorubicin, mediated by the induction of apoptosis, the decrease in the overexpression and activity of the ABC transporter P-gp. The work resulting from the second part of this project provided a deeper insight into the existing relationships between cardiolipin metabolism and chemoresistance thanks to the identification of alterations in content, composition of cardiolipins and key molecular factors which represent new potential therapeutic targets in order to restore the sensitivity of tumors to chemotherapies
Buchteile zum Thema "Lipid transporters"
Nagao, Kohjiro, Naoto Juni und Masato Umeda. „Membrane Lipid Transporters in Drosophila melanogaster“. In Bioactive Lipid Mediators, 165–80. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55669-5_12.
Der volle Inhalt der QuelleApell, Hans-Jürgen, und Valerij S. Sokolov. „Study of Ion Pump Activity Using Black Lipid Membranes“. In Pumps, Channels, and Transporters, 23–49. Hoboken, NJ: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119085126.ch2.
Der volle Inhalt der QuelleHisano, Yu, Tsuyoshi Nishi und Atsuo Kawahara. „Sphingosine 1-Phosphate Signaling via Transporters in Zebrafish and Mice“. In Bioactive Lipid Mediators, 207–20. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55669-5_15.
Der volle Inhalt der QuelleSalajegheh, Ali. „Adenosine Triphosphate-Binding Cassette (ABC) Lipid Transporters“. In Angiogenesis in Health, Disease and Malignancy, 11–15. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28140-7_2.
Der volle Inhalt der QuelleMarcel, Yves L., Mireille Ouimet und Ming-Dong Wang. „Cellular Lipid Traffic and Lipid Transporters: Regulation of Efflux and HDL Formation“. In Cellular Lipid Metabolism, 73–106. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00300-4_3.
Der volle Inhalt der QuelleModi, Chetna, Kaushik Kanada, Bhupendra Prajapati, Sohansinh Vaghela und Hiteshi Chadhaa. „Transfersomes as Transporters via Lipid-Based Drug Delivery System“. In Lipid-Based Drug Delivery Systems, 185–212. New York: Jenny Stanford Publishing, 2023. http://dx.doi.org/10.1201/9781003459811-7.
Der volle Inhalt der QuelleBonen, Arend, Joost J. F. R. Luiken und Jan F. C. Glatz. „Regulation of fatty acid transport and membrane transporters in health and disease“. In Cellular Lipid Binding Proteins, 181–92. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4419-9270-3_23.
Der volle Inhalt der QuelleAlpy, Fabien, und Catherine L. Tomasetto. „STARD3: A Lipid Transfer Protein in Breast Cancer and Cholesterol Trafficking“. In Cholesterol Transporters of the START Domain Protein Family in Health and Disease, 119–38. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1112-7_6.
Der volle Inhalt der QuelleIaea, David B., Shu Mao und Frederick R. Maxfield. „Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Proteins in Non-vesicular Cholesterol Transport“. In Cholesterol Transporters of the START Domain Protein Family in Health and Disease, 173–88. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1112-7_8.
Der volle Inhalt der QuelleClark, Barbara J., und Douglas M. Stocco. „An Introduction to the Steroidogenic Acute Regulatory Protein (StAR)-Related Lipid Transfer Domain Protein Family“. In Cholesterol Transporters of the START Domain Protein Family in Health and Disease, 1–14. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1112-7_1.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Lipid transporters"
Sundaresan, Vishnu Baba, und Donald J. Leo. „Actuation Using Protein Transporters Driven by Proton Gradient“. In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-15523.
Der volle Inhalt der QuelleMakhoul-Mansour, Michelle M., und Eric C. Freeman. „Photo-Triggered Soft Materials With Differentiated Diffusive Pathways“. In ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/smasis2019-5525.
Der volle Inhalt der QuelleSundaresan, Vishnu Baba, und Donald J. Leo. „Experimental Investigation for Chemo-Mechanical Actuation Using Biological Transport Mechanisms“. In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81366.
Der volle Inhalt der QuelleMalcata, F. Xavier. „Engineering of microalgae toward biodiesel: Facts and prospects“. In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/jeul5047.
Der volle Inhalt der QuelleZibert, A., S. Guttmann und HH Schmidt. „New role of copper transporter ATP7B in lipid metabolism of enterocytes“. In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402196.
Der volle Inhalt der QuelleSundaresan, Vishnu Baba, und Donald J. Leo. „Modeling and Characterization of a Chemomechanical Actuator Based on Protein Transporters“. In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43712.
Der volle Inhalt der QuelleChowdhury, Saiful M., Xuewei Zhu, Jason G. Williams, Kathleen M. Azzam, B. A. Merrick, Kenneth B. Tomer, John S. Parks und Michael B. Fessler. „ATP Binding Cassette Transporter A1 Regulates The Lipid Raft Proteome Of The Macrophage“. In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1970.
Der volle Inhalt der QuelleDixon, J. Brandon. „Engineering Tools for Studying the Interplay Between Mechanics and Biology in Lymphatic Lipid Transport“. In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19364.
Der volle Inhalt der QuelleNara, Matsunori. „Invention Using a Liposome of a Bio-Micromachine“. In ASME 4th Integrated Nanosystems Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/nano2005-87031.
Der volle Inhalt der QuelleMulugeta, S., und M. Zhao. „Chronic Expression of an Aberrantly Trafficked Mutant ABCA3 Lipid Transporter Promotes Selective Upregulation of the Unfolded Protein Response and Increased Amphisome-Mediated Autophagy“. In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4248.
Der volle Inhalt der QuelleBerichte der Organisationen zum Thema "Lipid transporters"
Cai, TingYu, Li Zhang, Ting Yang und Yang Gao. Effects of different dosages of Sodium-Glucose Transporter 2 Inhibitors on lipid levels in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0201.
Der volle Inhalt der QuelleBarg, Rivka, Kendal D. Hirschi, Avner Silber, Gozal Ben-Hayyim, Yechiam Salts und Marla Binzel. Combining Elevated Levels of Membrane Fatty Acid Desaturation and Vacuolar H+ -pyrophosphatase Activity for Improved Drought Tolerance. United States Department of Agriculture, Dezember 2012. http://dx.doi.org/10.32747/2012.7613877.bard.
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