Thematische Bibliographien / Light for bipolar disease

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Auswahl der wissenschaftlichen Literatur zum Thema „Light for bipolar disease“

Autor: Grafiati

Veröffentlicht am 25. Juni 2021

Zuletzt aktualisiert am 12. Februar 2022

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Zeitschriftenartikel zum Thema "Light for bipolar disease"

Fatemi, S. Hossein, Teri J. Reutiman und Timothy D. Folsom. „The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder“. Biochemical Society Transactions 37, Nr. 5 (21.09.2009): 1090–95. http://dx.doi.org/10.1042/bst0371090.

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Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4–4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy in the treatment of bipolar disorder, but their molecular targets and mode of action are largely unknown. A few studies have begun to shed light on potential targets of lithium treatment that may be involved in lithium's therapeutic effect. We have recently conducted a microarray study of rat frontal cortex following chronic treatment (21 days) with lithium. Chronic treatment with lithium led to a significant (at least 1.5-fold) down-regulation of 151 genes and up-regulation of 57 genes. We discuss our results in the context of previous microarray studies involving lithium and gene-association studies to identify key genes associated with chronic lithium treatment. A number of genes associated with bipolar disorder, including Comt (catechol-O-methyltransferase), Vapa (vesicle-associated membrane protein-associated protein A), Dtnb (dystrobrevin β) and Pkd1 (polycystic kidney disease 1), were significantly altered in our microarray dataset along with genes associated with synaptic transmission, apoptosis and transport among other functions.

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McClements, Michelle E., Federica Staurenghi, Meike Visel, John G. Flannery, Robert E. MacLaren und Jasmina Cehajic-Kapetanovic. „AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration“. BioMed Research International 2021 (09.02.2021): 1–8. http://dx.doi.org/10.1155/2021/4014797.

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Vision loss caused by inherited retinal degeneration affects millions of people worldwide, and clinical trials involving gene supplementation strategies are ongoing for select forms of the disease. When early therapeutic intervention is not possible and patients suffer complete loss of their photoreceptor cells, there is an opportunity for vision restoration techniques, including optogenetic therapy. This therapy provides expression of light-sensitive molecules to surviving cell types of the retina, enabling light perception through residual neuronal pathways. To this end, the bipolar cells make an obvious optogenetic target to enable upstream processing of visual signal in the retina. However, while AAV transduction of the bipolar cells has been described, the expression of human opsins in these cell types within a model of retinal degeneration (rd1) has been less successful. In this study, we have expanded the optogenetic toolkit and shown successful expression of human rhodopsin driven by an ON-bipolar cell promoter (Grm6) in the rd1 mouse model using modified AAV capsids (AAV2.4YF, AAV8.BP2, and AAV2.7m8) delivered via intraocular injection. We also show the first presentation of ectopic expression of human cone opsin in the bipolar cells of rd1 mice. These data provide evidence of an expansion of the optogenetic toolkit with the potential to restore useful visual function, setting the stage for future trials in human patients.

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Park, MiYoun, JiYoung Ahn, YeonJin Choi, MyeungNam Kim und JungYeon Lee. „The safety and efficacy of a combined diode laser and bipolar radiofrequency compared with combined infrared light and bipolar radiofrequency for skin rejuvenation“. Indian Journal of Dermatology, Venereology, and Leprology 78, Nr. 2 (2012): 146. http://dx.doi.org/10.4103/0378-6323.93630.

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Wadhwa, Ridhima, Riya Gupta und Pawan K. Maurya. „Oxidative Stress and Accelerated Aging in Neurodegenerative and Neuropsychiatric Disorder“. Current Pharmaceutical Design 24, Nr. 40 (15.03.2019): 4711–25. http://dx.doi.org/10.2174/1381612825666190115121018.

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Background: Neurodegenerative diseases are becoming more and more common in today’s world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal level in organisms causes neurodegenerative diseases. These neurodegenerative disorders like Alzeimers, Parkinsons disease and neuropsychiatric disorders such as schizophrenia, bipolar, depression are caused due to the decline in physiological and psychological functions caused by ROS and RNS. These ROS and RNS are formed as the result of excess oxidative damage in the system. Methods: The following article goes into detail explaining all the effects caused by excess oxidative damage like ROS/RNS formation and telomere shortening. Further, it explains the pathways of neurodegenerative diseases and neuropsychiatric diseases. This article also sheds light on the effective treatments of such disorders by changing lifestyle and activating antioxidant pathways. Conclusion: It is clear that neurodegenerative diseases are caused due to excess oxidative stress and alter the functioning of the central nervous system. The central nervous system undergoes neurodegenerative or neuropsychiatric changes.

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Carta, MG, V. Ruggiero, F. Sancassiani, F. Cutrano, AR Manca, M. Peri, A. Fais und E. Cacace. „The Use of Antidepressants in the Long-Term Treatment Should not Improve the Impact of Fibromyalgia on Quality of Life“. Clinical Practice & Epidemiology in Mental Health 9, Nr. 1 (12.07.2013): 120–24. http://dx.doi.org/10.2174/1745017901309010120.

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Background: Antidepressant (AD) drugs are effective in the short term treatment of fibromyalgia (FM). It may be useful to study the long-term impact of AD on patients with FM. Methods: One-year follow-up study on 23 females with FM divided into groups on AD (ADg-N=7), and not taking AD (NADg-N=11). Evaluation at t1 and at the end (t2) with the Fibromyalgia Impact Questionnaire (FIQ); at t2 with: SCID-IV; Mood Disorder Questionnaire (MDQ); Short Form-12; Hamilton Depression Rating Scale (HAM-D); Functioning Assessment Short Test (FAST) Results: After a year the AD group showed a worst impact of the disease by FIQ (p=0.017), worsened quality of life by SF-12 (p<0.01), and disability linked to bipolar symptoms by FAST (p=0.05). About 40% of the sample was screened positive at MDQ without difference in the two groups. The patients who recovered from a depressive episode did not differ between ADg and NADg (20% vs 33.3%), and were fewer than expected from the literature (40-60%). The HAM-D score at the end of the trial was worse in the ADg (p<0.03). Limitations: Observational research on few patients, not specifically designed to test the hypothesis. The results have a heuristic value only. Discussion: The results should be read in the light of the high prevalence of patients screened positive for Bipolar Disorders and of the well-known poor response of the mood symptoms to antidepressants in Bipolar Depression. The deterioration in the long-term management of FM patients following AD treatments suggests the need for new and robust studies.

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Smith, Rachel N., Amruta S. Agharkar und Eric B. Gonzales. „A review of creatine supplementation in age-related diseases: more than a supplement for athletes“. F1000Research 3 (15.09.2014): 222. http://dx.doi.org/10.12688/f1000research.5218.1.

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Creatine is an endogenous compound synthesized from arginine, glycine and methionine. This dietary supplement can be acquired from food sources such as meat and fish, along with athlete supplement powders. Since the majority of creatine is stored in skeletal muscle, dietary creatine supplementation has traditionally been important for athletes and bodybuilders to increase the power, strength, and mass of the skeletal muscle. However, new uses for creatine have emerged suggesting that it may be important in preventing or delaying the onset of neurodegenerative diseases associated with aging. On average, 30% of muscle mass is lost by age 80, while muscular weakness remains a vital cause for loss of independence in the elderly population. In light of these new roles of creatine, the dietary supplement’s usage has been studied to determine its efficacy in treating congestive heart failure, gyrate atrophy, insulin insensitivity, cancer, and high cholesterol. In relation to the brain, creatine has been shown to have antioxidant properties, reduce mental fatigue, protect the brain from neurotoxicity, and improve facets/components of neurological disorders like depression and bipolar disorder. The combination of these benefits has made creatine a leading candidate in the fight against age-related diseases, such as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, long-term memory impairments associated with the progression of Alzheimer’s disease, and stroke. In this review, we explore the normal mechanisms by which creatine is produced and its necessary physiology, while paying special attention to the importance of creatine supplementation in improving diseases and disorders associated with brain aging and outlining the clinical trials involving creatine to treat these diseases.

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Wanot, Bartosz, Barbara Szczygieł, Wojciech Wanot und Mariana Magerčiaková. „DEPRESSION - TYPES AND TREATMENT OF DEPRESSION“. Scientific Journal of Polonia University 32, Nr. 1 (03.04.2019): 121–30. http://dx.doi.org/10.23856/3216.

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The key symptom of depression is lowering the mood, but this is not the only sign of depression. Depression is a disease in which the symptoms reach various intensities and occur in many configurations. We distinguish the following types of depression: reactive, endogenous, neurotic, anankastic, agitated, large and small, morning (subclinical and subliminal), seasonal, masked, psychotic, postpartum, drug resistant, in children and adolescents, in the elderly, involutional, organic , in bipolar disorder, dysthymia, depression and anxiety, and in somatic diseases. Psychotherapy is now a popular and effective method of treating depression. The effects of treatment after the use of antidepressants appear only after a few weeks from the beginning of therapy. Old-generation medicines: these are tricyclic antidepressants (TLPDs), inhibitors of neuromediator reuptake and monoamine oxidase enzyme (IMAO) inhibitors. The new generation of drugs is distinguished by selective serotonin reuptake inhibitors (SSRIs), selective serotonin and noradrenaline reuptake inhibitors (SNRIs), four-ring drugs, noradrenaline reuptake inhibitors, selective reversible MAO inhibitors, and drugs with other mechanisms of action. Phototherapy (treatment of light) is currently a widely accepted method of winter depression therapy. Other treatments for depression include electroconvulsive therapy and transcranial magnetic stimulation.

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Oriolo, G., A. Brugués, J. M. Goikolea und L. Pintor. „Lamotrigine induced DRESS syndrome in bipolar disorder: Multiple snares behind a potentially life-threatening adverse reaction“. European Psychiatry 33, S1 (März 2016): S616. http://dx.doi.org/10.1016/j.eurpsy.2016.01.2304.

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BackgroundLamotrigine is widely used to prevent bipolar depression. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a rare, potentially life-threatening adverse effect. The long latency between drug exposure and disease onset, added to the high variability of its clinical presentation, can increase the risk of misdiagnosis lamotrigine withdrawal delay.ObjectiveTo highlight potential risk factors that can be related to a worse clinical onset and evolution of lamotrigine-induced DRESS syndrome.MethodsWe report the case of a 25-year-old-man, with a type I bipolar disorder, treated with lithium and lamotrigine 50 mg per day during the first 13 days of treatment, progressively increase up to 200 mg. Thirty-five days after the treatment initiation, a pruritic rash appeared in his upper arms, and scabies infestation was diagnosed. After 72 hours, the patient required urgent hospitalization due to hemodynamic instability.ResultsOn admission, facial edema and erythrodermia were involving 70 to 80% of the body surface. DRESS diagnosis due to lamotrigine was made following RegiSCAR criteria (Table 1). Psychiatric medication was stopped and DRESS treatment established. Complete recovery without recurrence was achieved after 2 months.ConclusionsThe lamotrigine up titration faster than recommended may have facilitated the DRESS syndrome reaction. Moreover, the latency between lamotrigine introduction and the rash onset could have increased the possibilities of misdiagnosis. In light of this, physicians need to consider at least the last 3 months treatment history when assessing a rash, as the delay of DRESS syndrome diagnosis can fastly lead to a fatal event.Table not available.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Lan, Yi-Feng Carol, Diane C. Zelman und Wen-Tao Chao. „Angry characters and frightened souls: Patients and family explanatory models of bipolar disorder in Taiwan“. Transcultural Psychiatry 55, Nr. 3 (19.03.2018): 317–38. http://dx.doi.org/10.1177/1363461518761924.

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Bipolar disorder (BD) affects a significant proportion of Taiwanese individuals (Weissman et al., 1996; Yang, Yeh, & Hwu, 2012). Psychotropic medications are typically the mainstay of treatment for BD, and there is an abundance of international research on biological etiology and medication options. However, there is comparatively little research on psychosocial aspects of BD, including how it is understood and managed within families. As culture provides the context in which psychiatric disease is managed, there is a need to identify distinct Chinese psychosocial perspectives that might shed light on intervention options. This research explored how Taiwanese patients and family members comprehend and cope with BD. A sample of 42 participants, including 20 Taiwanese patients diagnosed with Bipolar Disorder-I (BD-I) for at least 4 years, and 22 family members, participated in separate interviews on explanatory models of illness. Qualitative thematic analysis focused on features that were distinct from those in current Western research literature. Five themes were identified that represented Taiwanese conceptualizations of BD, notions of etiology, views regarding treatment, and the difficulties in managing the disorder. Participants used Chinese language terms and descriptions of BD that reflected greater concerns about irritability, anger, and family conflict than about other symptoms, and participants also emphasized characterological trait descriptions of the condition. Their responses reflected their acceptance of lifelong family responsibility for caretaking, clashing beliefs regarding biomedical versus traditional Chinese medical and spiritual models of etiology and cure, profound concerns about the effects of psychiatric medication on the liver and kidney systems, and a focus on stress rather than genetic or biological models of etiology.

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Liu, Zhuolin, Kazuhiro Kurokawa, Furu Zhang, John J. Lee und Donald T. Miller. „Imaging and quantifying ganglion cells and other transparent neurons in the living human retina“. Proceedings of the National Academy of Sciences 114, Nr. 48 (14.11.2017): 12803–8. http://dx.doi.org/10.1073/pnas.1711734114.

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Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human retina, GCs remain elusive due to their high optical translucency. Failure of conventional imaging—using predominately singly scattered light—to reveal GCs has led to a focus on multiply-scattered, fluorescence, two-photon, and phase imaging techniques to enhance GC contrast. Here, we show that singly scattered light actually carries substantial information that reveals GC somas, axons, and other retinal neurons and permits their quantitative analysis. We perform morphometry on GC layer somas, including projection of GCs onto photoreceptors and identification of the primary GC subtypes, even beneath nerve fibers. We obtained singly scattered images by: (i) marrying adaptive optics to optical coherence tomography to avoid optical blurring of the eye; (ii) performing 3D subcellular image registration to avoid motion blur; and (iii) using organelle motility inside somas as an intrinsic contrast agent. Moreover, through-focus imaging offers the potential to spatially map individual GCs to underlying amacrine, bipolar, horizontal, photoreceptor, and retinal pigment epithelium cells, thus exposing the anatomical substrate for neural processing of visual information. This imaging modality is also a tool for improving clinical diagnosis and assessing treatment of retinal disease.

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Dissertationen zum Thema "Light for bipolar disease"

Svanberg, Mira. „The right light at the right time for bipolar patients. An exploratory study of light environments for patients with bipolar disease in behavioral health clinics“. Thesis, KTH, Ljusdesign, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-297963.

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Research has showed that different light scenarios have a profound effect on hospitalized bipolar patients. Different light situations decrease the hospital stay for patients during both manic and depressive episodes. Nevertheless, a field study carried out during this thesis work of two arbitrary patient rooms in Swedish behavioral health clinics showed no incorporation of this knowledge in the light design of the rooms. Both patient rooms had insufficient light levels both in terms of circadian recommendations and perceived brightness. Hence this thesis suggests an improved light design for patient rooms housing bipolar patients. The basis of the improved design is to incorporate a dynamic, circadian lighting that varies depending on the patient's need and diagnosed episode.

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Hickey, Doron. „Optogenetic gene therapy for vision restoration : light-sensitive proteins, viral vectors and bipolar cell adaptation to a diseased state“. Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:820a45d5-60db-4c01-808a-8a3720c48f2c.

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Inherited retinal dystrophies are a heterogeneous group of retinal diseases that often lead to blindness. The diverse range of causative gene mutations poses great challenges to developing therapies to improve the vision of affected people. One technique being investigated is optogenetics for vision restoration, a technique that aims to deliver light-sensitising molecules to the affected retina. This research project provides data on a range of variables that need to be optimised in order to successfully restore vision using an optogenetic gene therapy approach. Fifteen wild type, chimeric and fusion constructs based on human opsins were compared by in vitro and in vivo tests to select the optimal light-sensitising construct. Of these, wild type rhodopsin, melanopsin and melanopsin-Ga subunit fusion constructs show the most promise for future studies. For delivery of the light-sensitising construct, the adeno-associated virus (AAV) serotype AAV2/2(7m8) was shown to perform best compared to two other AAV serotypes when tested in degenerate mouse eyes and macaque and human retinal explants. The importance of the delivery route to the eye, the use of a targeted versus non-targeted approach and the AAV vector concentration were all tested in in vivo experiments. In addition to testing such variables, the gene expression changes in target retinal bipolar cells in late-stage retinal degeneration were examined by microarray analysis of bipolar cell enriched samples isolated by fluorescence-activated cell sorting. Genes important for G protein signalling were generally expressed at a similar level in the degenerate state, while genes associated with oxidative stress and metabolism were differentially expressed. Collectively, these data will inform the choice of construct, delivery method and target cell in future research into optogenetic strategies for vision restoration.

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Quinn, Dale Edward Physics Australian Defence Force Academy UNSW. „Scattering of light by dust in bipolar outflow sources“. Awarded by:University of New South Wales - Australian Defence Force Academy. School of Physics, 2001. http://handle.unsw.edu.au/1959.4/38687.

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Interstellar dust plays an important role in the physics of the interstellar medium, as well as the formation and evolution of stars. The presence of dust is often indicated in optical images by dark lanes which bisect spiral galaxies, or seen directly as reflection nebulosity around stars or emission nebulosity if sufficient heating is present. Of interest in this thesis is the dust that is associated with bipolar outflow sources. Bipolar outflows can occur in either evolved stars or in young stellar objects, and are so named because they consist of two lobes which are thought to be due to out-flowing dust and gas, with a dark lane between them due to thick dust in a circumstellar disk or shell which often blocks the light from the central star. The spatial distribution of the properties of dust around bipolar outflow sources has been examined using a combination of theoretical and observational techniques. To aid the interpretation of observations of bipolar outflow sources, we have modelled the wavelength dependence of light from 0.36 to 22\um, scattered by dust particles with varying characteristics. The results were then presented in the form of colour excess ratios. These model ratios can be applied to observations if the contribution due to the central star is able to be removed, such that all that remains in the image is the effect of the dust particles. The scattering of light by dust particles was modelled by varying six different characteristics: grain material, size (particle radius from 0.002 to 0.75\um), mantle temperatures and thicknesses, shape, and orientation. Of those characteristics, the largest variation in the colour excess ratios resulted from varying grain composition and size. Different scattering angles also produce a noticeable variation in the colour excess ratios, however the effect is difficult to distinguish from the general extinction due to dust around the source. Water ice mantles were also found to significantly change the colour excess ratios. Grain shape and orientation produced only small variations in the colour excess ratios. Three bipolar outflow sources were studied as part of this thesis, two evolved objects, OH~231.8+4.2 and Mz\,3, and the young T-Tauri object Rno\,91. The observations involved multi-wavelength imaging in the infrared, from which colours and colour excess ratios were obtained at various points of the bipolar outflows and then compared to the predictions made in the modelling. The most extensive data set analysed was seven images of the object OH~231.8+4.2 which were used in a multi-wavelength study in the infrared H to N bands (1.25--12\um). The central source position of the object has been confined to less than an arcsec using the longer wavelength images and an L--M colour image. The two peaks which dominate the lobes in the shorter wavelength images were found to be scattering peaks where the light from the central source is scattered from the walls of the lobes. The spatial distribution of water ice in the nebula has also been constrained to the circumstellar disk which has a torus or disk shape rather than being a spherical shell. The colour excess ratios derived for the nebula from the images also suggest slightly different dust properties between the circumstellar disk, lobe walls and within the lobe cavities. The young T-Tauri star Rno\,91 also contains ice, and was observed between J and L. The central star which illuminates the nebula was shown to be coincident with the brightest point in these images. Using colour excess ratio results for various parts of the nebula, it was shown that the dust close to the central star is likely to contain larger grains than the diffuse ISM, but with a similar composition. Moving away from the central star, the dust becomes more like that observed in the diffuse ISM. The presence of water ice on dust close to the central star was confirmed using images centred in the ice band. The protoplanetary bipolar outflow source Mz\,3 is slightly more evolved than OH 231.8+4.2, and does not have evidence of any water ice in the circumstellar disk. Images of this object were obtained between J and 10\um. The presence of warm dust throughout the inner bipolar lobes of this object is noticeable by the brightness of the lobes in the image at 10\um. Line profiles through the position of the central source of the 10\um\ image demonstrate that there is a circumstellar shell close to the central source which has an inner radius of $\lta\,375$\,AU. Colour excess ratio results for the bipolar lobes suggest that the dust associated with Mz\,3 is generally smaller than that found in the diffuse ISM. The properties of the dust in the bipolar lobes were also observed to be different to the dust closer to the central source and lying in the circumstellar disk. The small sizes for dust in Mz\,3 is consistent with the high velocity outflows that have been associated with the object.

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Beauchemin, Kathleen Mary. „Nocturnal psychopathology : sleep, dreaming, mood and light-therapy in bipolar disorder /“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22949.pdf.

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Douman, Samantha Fiona. „Development of Highly Sensitive Electrochemiluminescence Platforms and Application in Disease Biomarker Immunosensing“. University of the Western Cape, 2018. http://hdl.handle.net/11394/6238.

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Philosophiae Doctor - PhD (Chemistry)
Electrochemiluminescence (ECL) is a light-emitting process generated by electrochemical redox reactions and has been widely used as an analytical tool, especially in the field of biosensing, that is, immunoassays and DNA-probe assays. Thus, the scope of this work was to develop a simple, sensitive ECL immunosensor for cardiac injury and to study and present insights into newly fabricated platforms for bioanalytical applications by using ECL as detection mechanism.
2021-08-31

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Mazade, Reece Eric. „Modulation Of Inner Retinal Inhibition With Light Adaptation“. Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/565903.

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The retina is able to adjust its signaling over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels, such as during the day, due to changes in the organization of retinal receptive fields. This process is commonly referred to as light adaptation. These organizational changes have been shown to occur at the level of the ganglion cells, the output neurons of the retina, which have shifts in their excitatory center-inhibitory surround receptive fields that increase their sensitivity to small stimuli. Recent work supports the idea that light-adapted changes in ganglion cell spatial sensitivity are due in part to inner retinal signaling changes, possibly including changes to inhibition onto bipolar cells, the interneurons at the center of retinal signal processing. However, it is unknown how inhibition to the bipolar cells changes with light adaptation, how any changes affect the light signal or what mediates the changes to the bipolar cells that have been suggested by previous reports. To determine how light adaptation affects bipolar cell inhibition, the inhibitory inputs to OFF bipolar cells were measured. OFF bipolar cells, which respond to the offset of light, in particular may be involved in retinal adaptation as they bridge dim- and bright-light retinal pathways. Their inputs were compared between dark- and light-adapted conditions to determine how any inhibitory changes affects their output onto downstream ganglion cells. We found that there was a compensatory switch from primarily glycinergic-mediated inhibition to OFF bipolar cells in the dark to primarily GABAergic-mediated inhibition in the light. Since glycinergic and GABAergic inhibition perform very different roles and are mediated by morphologically different cells, it is likely this switch underlies a change in the spatial distribution of inhibition to these cells. We found that the spatial inhibitory input to OFF bipolar cells became significantly smaller and narrower with light adaptation, translating to smaller inhibitory surrounds of the OFF bipolar cell receptive fields. Through a model, our data suggested that the OFF bipolar cell output to downstream ganglion cells was stronger in the light, due to the narrowing and reduction in the spatial input, to small light stimuli. This would effectively be one way the retina could use to increase visual acuity. Additionally, we found that the inhibitory changes to OFF bipolar cells with light-adaptation are partially mediated by dopamine D1 receptor signaling. Dopamine is released in the light and has been shown to be an important modulator of retinal light-adaptation. However, there are likely other factors involved in mediating inhibitory changes to OFF bipolar cells. Through these studies, we show that light adaptation heavily influences inner retina inhibition and likely plays a prominent role in determining and shaping light signals under different ambient light conditions which may ultimately be one mechanism for increasing visual sensitivity and acuity.

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Lee, Tik Ho. „Synthesis and characterization of electroluminescent bipolar small molecules and polymers“. HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/878.

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Madeira, A. C. A. „Growth, light interception and disease in field bean“. Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384294.

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Duis, Christine Ann. „THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLES“. University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990818739.

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Fiedorowicz, Jess G. „Course of illness and the development of vascular disease in individuals with bipolar disorder“. Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2699.

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For over a century, there have been suggestions of a link between what is currently called bipolar disorder and cardiovascular mortality. In the contemporary epidemiological literature, this risk has been confirmed and approximates twice that expected based on age and gender. To date, however, this information has come primarily from clinical samples, which carry considerable risk of selection bias. The studies contained in this dissertation sought to assess this relationship using methods less vulnerable to selection bias and to determine the role that course of illness and treatments for illness may play in the development of vascular disease. In a nationally representative sample, we confirmed a link between mood disorders and vascular disease, which was particularly pronounced in women with bipolar disorder. In subsequent studies, a dose-response relationship between the duration of clinically significant hypomanic or manic symptoms and both cardiovascular mortality and endothelial function was seen. While medication exposure did not appear related to mortality or endothelial function, first generation antipsychotics were associated with arterial stiffness, an effect apparently mediated by elevations in blood pressure. In cross-sectional samples, our data suggests that vasculopathy is not present early in the course of bipolar disorder although is much greater than expected later in the course of illness. This dissertation purports that vasculopathy develops over the long-term course of bipolar disorder, is proportional to symptom burden, and is influenced by health behaviors and treatments. These findings may provide opportunities for clinicians and those afflicted to intervene to address this excess risk of vascular morbidity and mortality.

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Bücher zum Thema "Light for bipolar disease"

John, Wallace. Alcoholism: New light on the disease. Newport, RI: Edgehill Publications, 1985.

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J, Wallace. Alcoholism: New light on the disease. [S.l.]: [s.n.], 1985.

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Borrowed light: A novel. Dallas, TX: Southern Methodist University Press, 2002.

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Danielle, Steel. His Bright Light. London: Transworld, 2009.

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Traveling light. Thorndike, Me: G.K. Hall, 2000.

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Kittle, Katrina. Traveling Light. New York: HarperCollins, 2008.

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Traveling light. New York: Warner Books, 2000.

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Kittle, Katrina. Traveling light. New York, NY: Warner Books, 2008.

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Laurie, Becklund, und Polson Beth, Hrsg. Go toward the light. New York: Harper & Row, 1988.

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Preston, John. Winter's light: Reflections of a Yankee queer. Hanover, NH: University Press of New England, 1995.

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Buchteile zum Thema "Light for bipolar disease"

Farr, Jack. „Unicompartmental bipolar disease“. In Chondral Disease of the Knee, 28–30. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-38299-9_10.

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Leung, Alexander K. C., Marcus Schmitt, Christie P. Thomas, Cord Sunderkötter, Meinhard Schiller, Thomas Schwarz, Mark Berneburg et al. „Bipolar Disorder“. In Encyclopedia of Molecular Mechanisms of Disease, 226–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_239.

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Hill, Keith, Tom Baranowski, Walter Schmidt, Nicole Prommer, Michel Audran, Philippe Connes, Ramiro L. Gutiérrez et al. „Bipolar disorder“. In Encyclopedia of Exercise Medicine in Health and Disease, 119. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2153.

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Leung, Alexander K. C., Marcus Schmitt, Christie P. Thomas, Cord Sunderkötter, Meinhard Schiller, Thomas Schwarz, Mark Berneburg et al. „Bipolar Affective Disorder“. In Encyclopedia of Molecular Mechanisms of Disease, 226. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7321.

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Byars, Joanne A., und Jess G. Fiedorowicz. „Cerebrovascular Disease and Bipolar Disorder“. In Neuropsychiatric Symptoms of Neurological Disease, 307–30. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-2428-3_14.

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Smith, Michael D. „A Model for Bipolar Sources in Molecular Clouds“. In Light on Dark Matter, 319–20. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4672-9_71.

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Vieta, Eduard. „Etiology and Disease Course“. In Managing Bipolar Disorder in Clinical Practice, 23–39. Tarporley: Springer Healthcare Ltd., 2013. http://dx.doi.org/10.1007/978-1-908517-94-4_3.

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Berrettini, Wade H. „The Molecular Genetics of Bipolar Disease“. In Biology of Depressive Disorders. Part A, 189–204. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4757-9498-4_9.

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Zeldenrust, Steven R., Donna J. Lager und Nelson Leung. „Light Chain Deposition Disease“. In Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders, 197–203. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-08885-2_8.

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Kattah, Andrea, und Nelson Leung. „Light Chain Deposition Disease“. In Glomerulonephritis, 1–18. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27334-1_39-1.

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Konferenzberichte zum Thema "Light for bipolar disease"

Guidi, Andrea, Jean Schoentgen, Gilles Bertschy, Claudio Gentili, Luigi Landini, Enzo Pasquale Scilingo und Nicola Vanello. „Voice quality in patients suffering from bipolar disease“. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7319785.

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Lu, Feng, Jongwon Lee, Aiting Jiang, Seungyong Jung und Mikhail A. Belkin. „Monolithic bipolar thermopile detector sensitive to light ellipticity“. In CLEO: QELS_Fundamental Science. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cleo_qels.2016.ff1b.3.

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Wang, Xue, Mengmeng Han, Qiyan Wang, Yuhui Zeng, Qingqiang Meng, Jun Zhang und Xunbin Wei. „A light therapy for treating Alzheimer's disease“. In SPIE BiOS, herausgegeben von Wei R. Chen. SPIE, 2017. http://dx.doi.org/10.1117/12.2253476.

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Li, Lu, Junsheng Yu, Zhu Ma und Yadong Jiang. „Organic light-emitting diodes based on bipolar material FLAMB-1T“. In 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies, herausgegeben von Ya-Dong Jiang, Bernard Kippelen und Junsheng Yu. SPIE, 2010. http://dx.doi.org/10.1117/12.865468.

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Deliwala, Shrenik. „Light matters: Integrated opto-electronics from consumer to communications“. In 2013 IEEE Bipolar/BiCMOS Circuits and Technology Meeting - BCTM. IEEE, 2013. http://dx.doi.org/10.1109/bctm.2013.6798165.

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Tao, Lechan, Xue Wang, Quanqu Zhou und Xunbin Wei. „Near infra-red light treatment of Alzheimer’s disease“. In Biophotonics and Immune Responses XIV, herausgegeben von Wei R. Chen. SPIE, 2019. http://dx.doi.org/10.1117/12.2512618.

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Yu, Guoqiang, Turgut Durduran, Chao Zhou, Gwen Lech, Emile R. Mohler und Arjun G. Yodh. „Assessment of Muscle Vascular Disease with Diffuse Light“. In Biomedical Topical Meeting. Washington, D.C.: OSA, 2006. http://dx.doi.org/10.1364/bio.2006.me44.

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Xing, Xiaoman, Emile R. Mohler, Turgut Duduran, Chao Zhou, Gwen Lech, Arjun Yodh und Guoqiang Yu. „Diffuse Light Quantification of Peripheral Artery Disease (PAD)“. In Biomedical Optics. Washington, D.C.: OSA, 2008. http://dx.doi.org/10.1364/biomed.2008.bsue56.

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Kunnath Velayudhan, S., D. Santoriello, S. M. Coley, G. Bhagat, T. V. Colby und A. Saqi. „Cystic Lung: Manifestation of Light Chain Deposition Disease“. In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6294.

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Han, Mengmeng, Qiyan Wang, Yuhui Zeng, Qingqiang Meng, Jun Zhang und Xunbin Wei. „Studying infrared light therapy for treating Alzheimer's disease“. In SPIE BiOS, herausgegeben von Wei R. Chen. SPIE, 2016. http://dx.doi.org/10.1117/12.2212283.

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Berichte der Organisationen zum Thema "Light for bipolar disease"

Wang, Y. Z., D. D. Gebler, D. K. Fu, T. M. Swager und A. J. Epstein. Color Variable Bipolar/AC Light-Emitting Devices Based on Conjugated Polymers. Fort Belvoir, VA: Defense Technical Information Center, September 1997. http://dx.doi.org/10.21236/ada330318.

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Gregory, Don A., II Outerbridge und Gregory J. Optical Correlation Based Pose Estimation Using Bipolar Amplitude Spatial Light Modulators. Fort Belvoir, VA: Defense Technical Information Center, Dezember 2008. http://dx.doi.org/10.21236/ada574398.

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Siskaninetz, William J., J. E. Ehret, J. A. Lott, J. C. Griffith, T. R. Nelson und Jr. Enhanced Performance of Bipolar Cascade Light Emitting Diodes by Doping the Aluminum Oxide Apertures. Fort Belvoir, VA: Defense Technical Information Center, November 2004. http://dx.doi.org/10.21236/ada429346.

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Wang, HongZhou, WanHua Wang, HaiCun Shi, LiJian Han und PingLei Pan. Blood neurofilament light chain in Parkinson’s disease and atypical parkinsonisms: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Juli 2020. http://dx.doi.org/10.37766/inplasy2020.7.0091.

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Wang, HongZhou, WanHua Wang, HaiCun Shi, LiJian Han und PingLei Pan. Cerebrospinal fluid and blood levels of neurofilament light chain in Parkinson's disease: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, Juni 2020. http://dx.doi.org/10.37766/inplasy2020.6.0025.

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Viswanathan, Meera, Jennifer Cook Middleton, Alison Stuebe, Nancy Berkman, Alison N. Goulding, Skyler McLaurin-Jiang, Andrea B. Dotson et al. Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions. Agency for Healthcare Research and Quality (AHRQ), April 2021. http://dx.doi.org/10.23970/ahrqepccer236.

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Background. Untreated maternal mental health disorders can have devastating sequelae for the mother and child. For women who are currently or planning to become pregnant or are breastfeeding, a critical question is whether the benefits of treating psychiatric illness with pharmacologic interventions outweigh the harms for mother and child. Methods. We conducted a systematic review to assess the benefits and harms of pharmacologic interventions compared with placebo, no treatment, or other pharmacologic interventions for pregnant and postpartum women with mental health disorders. We searched four databases and other sources for evidence available from inception through June 5, 2020 and surveilled the literature through March 2, 2021; dually screened the results; and analyzed eligible studies. We included studies of pregnant, postpartum, or reproductive-age women with a new or preexisting diagnosis of a mental health disorder treated with pharmacotherapy; we excluded psychotherapy. Eligible comparators included women with the disorder but no pharmacotherapy or women who discontinued the pharmacotherapy before pregnancy. Results. A total of 164 studies (168 articles) met eligibility criteria. Brexanolone for depression onset in the third trimester or in the postpartum period probably improves depressive symptoms at 30 days (least square mean difference in the Hamilton Rating Scale for Depression, -2.6; p=0.02; N=209) when compared with placebo. Sertraline for postpartum depression may improve response (calculated relative risk [RR], 2.24; 95% confidence interval [CI], 0.95 to 5.24; N=36), remission (calculated RR, 2.51; 95% CI, 0.94 to 6.70; N=36), and depressive symptoms (p-values ranging from 0.01 to 0.05) when compared with placebo. Discontinuing use of mood stabilizers during pregnancy may increase recurrence (adjusted hazard ratio [AHR], 2.2; 95% CI, 1.2 to 4.2; N=89) and reduce time to recurrence of mood disorders (2 vs. 28 weeks, AHR, 12.1; 95% CI, 1.6 to 91; N=26) for bipolar disorder when compared with continued use. Brexanolone for depression onset in the third trimester or in the postpartum period may increase the risk of sedation or somnolence, leading to dose interruption or reduction when compared with placebo (5% vs. 0%). More than 95 percent of studies reporting on harms were observational in design and unable to fully account for confounding. These studies suggested some associations between benzodiazepine exposure before conception and ectopic pregnancy; between specific antidepressants during pregnancy and adverse maternal outcomes such as postpartum hemorrhage, preeclampsia, and spontaneous abortion, and child outcomes such as respiratory issues, low Apgar scores, persistent pulmonary hypertension of the newborn, depression in children, and autism spectrum disorder; between quetiapine or olanzapine and gestational diabetes; and between benzodiazepine and neonatal intensive care admissions. Causality cannot be inferred from these studies. We found insufficient evidence on benefits and harms from comparative effectiveness studies, with one exception: one study suggested a higher risk of overall congenital anomalies (adjusted RR [ARR], 1.85; 95% CI, 1.23 to 2.78; N=2,608) and cardiac anomalies (ARR, 2.25; 95% CI, 1.17 to 4.34; N=2,608) for lithium compared with lamotrigine during first- trimester exposure. Conclusions. Few studies have been conducted in pregnant and postpartum women on the benefits of pharmacotherapy; many studies report on harms but are of low quality. The limited evidence available is consistent with some benefit, and some studies suggested increased adverse events. However, because these studies could not rule out underlying disease severity as the cause of the association, the causal link between the exposure and adverse events is unclear. Patients and clinicians need to make an informed, collaborative decision on treatment choices.

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