Zeitschriftenartikel zum Thema „Ligand/substrate identification“
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Singh, Manvi, Priya Kempanna und Kavitha Bharatham. „Identification of Mtb GlmU Uridyltransferase Domain Inhibitors by Ligand-Based and Structure-Based Drug Design Approaches“. Molecules 27, Nr. 9 (28.04.2022): 2805. http://dx.doi.org/10.3390/molecules27092805.
Der volle Inhalt der QuelleRothweiler, Elisabeth M., Paul E. Brennan und Kilian V. M. Huber. „Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators“. Biological Chemistry 403, Nr. 4 (23.02.2022): 391–402. http://dx.doi.org/10.1515/hsz-2021-0396.
Der volle Inhalt der QuelleFernández, Rico-Jiménez, Ortega, Daddaoua, García García, Martín-Mora, Torres, Tajuelo, Matilla und Krell. „Determination of Ligand Profiles for Pseudomonas aeruginosa Solute Binding Proteins“. International Journal of Molecular Sciences 20, Nr. 20 (17.10.2019): 5156. http://dx.doi.org/10.3390/ijms20205156.
Der volle Inhalt der QuelleWang, Wenyuan, Junli Zhu, Qi Huang, Lei Zhu, Ding Wang, Weimin Li und Wenjie Yu. „DFT Exploration of Metal Ion–Ligand Binding: Toward Rational Design of Chelating Agent in Semiconductor Manufacturing“. Molecules 29, Nr. 2 (08.01.2024): 308. http://dx.doi.org/10.3390/molecules29020308.
Der volle Inhalt der QuelleWeng, Z., S. M. Thomas, R. J. Rickles, J. A. Taylor, A. W. Brauer, C. Seidel-Dugan, W. M. Michael, G. Dreyfuss und J. S. Brugge. „Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains“. Molecular and Cellular Biology 14, Nr. 7 (Juli 1994): 4509–21. http://dx.doi.org/10.1128/mcb.14.7.4509-4521.1994.
Der volle Inhalt der QuelleWeng, Z., S. M. Thomas, R. J. Rickles, J. A. Taylor, A. W. Brauer, C. Seidel-Dugan, W. M. Michael, G. Dreyfuss und J. S. Brugge. „Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.“ Molecular and Cellular Biology 14, Nr. 7 (Juli 1994): 4509–21. http://dx.doi.org/10.1128/mcb.14.7.4509.
Der volle Inhalt der QuelleEvans, S. W., D. Rennick und W. L. Farrar. „Identification of a signal-transduction pathway shared by haematopoietic growth factors with diverse biological specificity“. Biochemical Journal 244, Nr. 3 (15.06.1987): 683–91. http://dx.doi.org/10.1042/bj2440683.
Der volle Inhalt der QuelleDuarte Filho, Luiz Antonio Miranda de Souza, Cintia Emi Yanaguibashi Leal, Pierre-Edouard Bodet, Edilson Beserra de Alencar Filho, Jackson Roberto Guedes da Silva Almeida, Manon Porta Zapata, Oussama Achour et al. „The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy“. Marine Drugs 22, Nr. 6 (27.05.2024): 244. http://dx.doi.org/10.3390/md22060244.
Der volle Inhalt der QuelleDrexler, Hannes C. A., Matthias Vockel, Christian Polaschegg, Maike Frye, Kevin Peters und Dietmar Vestweber. „Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2“. Molecular & Cellular Proteomics 18, Nr. 10 (19.08.2019): 2058–77. http://dx.doi.org/10.1074/mcp.ra119.001716.
Der volle Inhalt der QuelleLamaze, C., und S. L. Schmid. „Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.“ Journal of Cell Biology 129, Nr. 1 (01.04.1995): 47–54. http://dx.doi.org/10.1083/jcb.129.1.47.
Der volle Inhalt der QuelleMora Lagares, Liadys, Yunierkis Pérez-Castillo, Nikola Minovski und Marjana Novič. „Structure–Function Relationships in the Human P-Glycoprotein (ABCB1): Insights from Molecular Dynamics Simulations“. International Journal of Molecular Sciences 23, Nr. 1 (29.12.2021): 362. http://dx.doi.org/10.3390/ijms23010362.
Der volle Inhalt der QuelleRuan, Ke-He. „High resolution nuclear magnetic resonance spectroscopy-guided mutagenesis for characterization of membrane-bound proteins: Experimental designs and applications“. Spectroscopy 18, Nr. 1 (2004): 13–29. http://dx.doi.org/10.1155/2004/802728.
Der volle Inhalt der QuelleReynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu und Z. Zhang. „Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes“. Molecular and Cellular Biology 14, Nr. 12 (Dezember 1994): 8333–42. http://dx.doi.org/10.1128/mcb.14.12.8333-8342.1994.
Der volle Inhalt der QuelleReynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu und Z. Zhang. „Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.“ Molecular and Cellular Biology 14, Nr. 12 (Dezember 1994): 8333–42. http://dx.doi.org/10.1128/mcb.14.12.8333.
Der volle Inhalt der QuelleAdams, James, Benjamin P. Thornton und Lydia Tabernero. „A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis“. International Journal of Molecular Sciences 22, Nr. 22 (11.11.2021): 12206. http://dx.doi.org/10.3390/ijms222212206.
Der volle Inhalt der QuelleYadav, Rolly, Anwesh Pandey, Nidhi Awasthi und Anamika Shukla. „Molecular Docking Studies of Enzyme Binding Drugs on Family of Cytochrome P450“. Advanced Science, Engineering and Medicine 12, Nr. 1 (01.01.2020): 83–87. http://dx.doi.org/10.1166/asem.2020.2520.
Der volle Inhalt der QuelleBARNETT, Stanley F., Deborah DEFEO-JONES, Sheng FU, Paula J. HANCOCK, Kathleen M. HASKELL, Raymond E. JONES, Jason A. KAHANA et al. „Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors“. Biochemical Journal 385, Nr. 2 (07.01.2005): 399–408. http://dx.doi.org/10.1042/bj20041140.
Der volle Inhalt der QuelleWei, Min, Richard Wynn, Gregory Hollis, Boshan Liao, Alexander Margulis, Brian G. Reid, Ronald Klabe et al. „High-Throughput Determination of Mode of Inhibition in Lead Identification and Optimization“. Journal of Biomolecular Screening 12, Nr. 2 (11.01.2007): 220–28. http://dx.doi.org/10.1177/1087057106296679.
Der volle Inhalt der QuelleTakeuchi, Hajime, Daniel J. Rigden, Bahram Ebrahimi, Philip C. Turner und Huw H. Rees. „Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration“. Biochemical Journal 389, Nr. 3 (26.07.2005): 637–45. http://dx.doi.org/10.1042/bj20050498.
Der volle Inhalt der QuelleD’Arrigo, Giulia, Ida Autiero, Eleonora Gianquinto, Lydia Siragusa, Massimo Baroni, Gabriele Cruciani und Francesca Spyrakis. „Exploring Ligand Binding Domain Dynamics in the NRs Superfamily“. International Journal of Molecular Sciences 23, Nr. 15 (05.08.2022): 8732. http://dx.doi.org/10.3390/ijms23158732.
Der volle Inhalt der QuelleBasu, Nirmalya, Rashna Bhandari, Vivek T. Natarajan und Sandhya S. Visweswariah. „Cross Talk between Receptor Guanylyl Cyclase C and c-src Tyrosine Kinase Regulates Colon Cancer Cell Cytostasis“. Molecular and Cellular Biology 29, Nr. 19 (20.07.2009): 5277–89. http://dx.doi.org/10.1128/mcb.00001-09.
Der volle Inhalt der QuelleAstegno, Alessandra, Alejandro Giorgetti, Alessandra Allegrini, Barbara Cellini und Paola Dominici. „Characterization of C-S Lyase fromC. diphtheriae: A Possible Target for New Antimicrobial Drugs“. BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/701536.
Der volle Inhalt der QuelleSanguinetti, Manuel, Lucianna Helene Silva Santos, Juliette Dourron, Catalina Alamón, Juan Idiarte, Sotiris Amillis, Sergio Pantano und Ana Ramón. „Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter“. International Journal of Molecular Sciences 23, Nr. 24 (16.12.2022): 16039. http://dx.doi.org/10.3390/ijms232416039.
Der volle Inhalt der QuelleXia, Daosong, Renwen Zheng, Jianhua Huang, Sihan Lu und Qingfeng Tang. „Identification and Functional Analysis of Glutathione S-Transferases from Sitophilus zeamais in Olfactory Organ“. Insects 13, Nr. 3 (05.03.2022): 259. http://dx.doi.org/10.3390/insects13030259.
Der volle Inhalt der QuelleThakur, Priti, Jowad Atway, Patrick A. Limbach und Balasubrahmanyam Addepalli. „RNA Cleavage Properties of Nucleobase-Specific RNase MC1 and Cusativin Are Determined by the Dinucleotide-Binding Interactions in the Enzyme-Active Site“. International Journal of Molecular Sciences 23, Nr. 13 (24.06.2022): 7021. http://dx.doi.org/10.3390/ijms23137021.
Der volle Inhalt der QuelleMilot, Marie-Michelle, und Adrian Hofmann. „Shikimate kinase-like 1 plays an integral role in chloroplast biogenesis“. Acta Crystallographica Section A Foundations and Advances 70, a1 (05.08.2014): C452. http://dx.doi.org/10.1107/s2053273314095473.
Der volle Inhalt der QuelleVenkatraman, Janani, Jyothi Bhat, Suresh M. Solapure, Jatheendranath Sandesh, Debasmita Sarkar, Sundaram Aishwarya, Kakoli Mukherjee et al. „Screening, Identification, and Characterization of Mechanistically Diverse Inhibitors of the Mycobacterium Tuberculosis Enzyme, Pantothenate Kinase (CoaA)“. Journal of Biomolecular Screening 17, Nr. 3 (15.11.2011): 293–302. http://dx.doi.org/10.1177/1087057111423069.
Der volle Inhalt der QuelleN'Diaye, Elsa-Noah, Aylin C. Hanyaloglu, Kimberly K. Kajihara, Manojkumar A. Puthenveedu, Ping Wu, Mark von Zastrow und Eric J. Brown. „The Ubiquitin-like Protein PLIC-2 Is a Negative Regulator of G Protein-coupled Receptor Endocytosis“. Molecular Biology of the Cell 19, Nr. 3 (März 2008): 1252–60. http://dx.doi.org/10.1091/mbc.e07-08-0775.
Der volle Inhalt der QuellePallen, C. J., D. S. Y. Lai, H. P. Chia, I. Boulet und P. H. Tong. „Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes“. Biochemical Journal 276, Nr. 2 (01.06.1991): 315–23. http://dx.doi.org/10.1042/bj2760315.
Der volle Inhalt der QuellePowell, David W., Madhavi J. Rane, Brian A. Joughin, Ralitsa Kalmukova, Jeong-Ho Hong, Bruce Tidor, William L. Dean et al. „Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding“. Molecular and Cellular Biology 23, Nr. 15 (01.08.2003): 5376–87. http://dx.doi.org/10.1128/mcb.23.15.5376-5387.2003.
Der volle Inhalt der QuelleDryuchko, Oleksandr, Natalia Bunyakina, Bogdan Korobko, Oleksandr Shefer, Kateryna Kytaihora und Iryna Ivanytska. „SEARCH FOR WAYS OF CONTROLLED MODIFICATION OF CHARACTERISTICS OF FUNCTIONAL UNITS OF ADAPTIVE AIR PURIFICATION SYSTEMS“. Bulletin of the National Technical University "KhPI". Series: Chemistry, Chemical Technology and Ecology, Nr. 2(6) (23.12.2021): 34–51. http://dx.doi.org/10.20998/2079-0821.2021.02.06.
Der volle Inhalt der QuelleAytenfisu, Asaminew H., Daniel Deredge, Erik H. Klontz, Jonathan Du, Eric J. Sundberg und Alexander D. MacKerell. „Insights into substrate recognition and specificity for IgG by Endoglycosidase S2“. PLOS Computational Biology 17, Nr. 7 (26.07.2021): e1009103. http://dx.doi.org/10.1371/journal.pcbi.1009103.
Der volle Inhalt der QuelleByrne, Dominic P., Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry et al. „New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors“. Biochemical Journal 475, Nr. 15 (14.08.2018): 2435–55. http://dx.doi.org/10.1042/bcj20180266.
Der volle Inhalt der QuelleLobell, Robert B., Joseph P. Davide, Nancy E. Kohl, H. Donald Burns, Wai-Si Eng und Raymond E. Gibson. „A Cell-Based Radioligand Binding Assay for Farnesyl: Protein Transferase Inhibitors“. Journal of Biomolecular Screening 8, Nr. 4 (August 2003): 430–38. http://dx.doi.org/10.1177/1087057103256153.
Der volle Inhalt der QuelleVargas-Pérez, María de los Ángeles, Damien Paul Devos und Guillermo López-Lluch. „An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex“. Antioxidants 13, Nr. 4 (21.04.2024): 496. http://dx.doi.org/10.3390/antiox13040496.
Der volle Inhalt der QuelleMa, Peilin, Raghuveer Mali, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims et al. „KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML“. Blood 118, Nr. 21 (18.11.2011): 868. http://dx.doi.org/10.1182/blood.v118.21.868.868.
Der volle Inhalt der QuelleWang, Xingdong, Jie Pei, Pengjia Bao, Chunnian Liang, Min Chu, Shaoke Guo, Ping Yan und Xian Guo. „Identification of Yak’s TLR4 Alternative Spliceosomes and Bioinformatic Analysis of TLR4 Protein Structure and Function“. Animals 11, Nr. 1 (26.12.2020): 32. http://dx.doi.org/10.3390/ani11010032.
Der volle Inhalt der QuellePerduca, Massimiliano, Michele Bovi, Mattia Bertinelli, Edoardo Bertini, Laura Destefanis, Maria E. Carrizo, Stefano Capaldi und Hugo L. Monaco. „High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase“. Acta Crystallographica Section D Biological Crystallography 70, Nr. 8 (25.07.2014): 2125–38. http://dx.doi.org/10.1107/s1399004714012462.
Der volle Inhalt der QuelleZECHEL, David L., Shouming HE, Claude DUPONT und Stephen G. WITHERS. „Identification of Glu-120 as the catalytic nucleophile in Streptomyces lividans endoglucanase CelB“. Biochemical Journal 336, Nr. 1 (15.11.1998): 139–45. http://dx.doi.org/10.1042/bj3360139.
Der volle Inhalt der QuelleCooper, William C., Yi Jin und Trevor M. Penning. „Elucidation of a Complete Kinetic Mechanism for a Mammalian Hydroxysteroid Dehydrogenase (HSD) and Identification of All Enzyme Forms on the Reaction Coordinate“. Journal of Biological Chemistry 282, Nr. 46 (11.09.2007): 33484–93. http://dx.doi.org/10.1074/jbc.m703414200.
Der volle Inhalt der QuellePurushotham, K. R., Y. Nakagawa, M. G. Humphreys-Beher, N. Maeda und C. A. Schneyer. „Rat Parotid Gland Acinar Cell Proliferation: Signal Transduction at the Plasma Membrane“. Critical Reviews in Oral Biology & Medicine 4, Nr. 3 (April 1993): 537–43. http://dx.doi.org/10.1177/10454411930040034001.
Der volle Inhalt der QuelleDiaz-Bárcena, Alba, Luis Fernandez-Pacios und Patricia Giraldo. „Structural Characterization and Molecular Dynamics Study of the REPI Fusion Protein from Papaver somniferum L.“ Biomolecules 14, Nr. 1 (19.12.2023): 2. http://dx.doi.org/10.3390/biom14010002.
Der volle Inhalt der QuelleGómez-Melero, Sara, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Javier Caballero-Villarraso, Isaac Túnez und Elier Paz-Rojas. „Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout“. Biomedicines 10, Nr. 2 (10.02.2022): 422. http://dx.doi.org/10.3390/biomedicines10020422.
Der volle Inhalt der QuelleChao, Nan, Wen-Ting Jiang, Xue-Chun Wang, Xiang-Ning Jiang und Ying Gai. „Novel motif is capable of determining CCR and CCR-like proteins based on the divergence of CCRs in plants“. Tree Physiology 39, Nr. 12 (21.11.2019): 2019–26. http://dx.doi.org/10.1093/treephys/tpz098.
Der volle Inhalt der QuelleZhao, Yi, Eliud Morales Morales Dávila, Xue Li, Beiyu Tang, Ariana I. Rabinowitsch, Jose Manuel Perez-Aguilar und Carl P. Blobel. „Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17“. International Journal of Molecular Sciences 23, Nr. 21 (24.10.2022): 12796. http://dx.doi.org/10.3390/ijms232112796.
Der volle Inhalt der QuelleAlves, Krisnna M. A., Fábio José Bonfim Cardoso, Kathia M. Honorio und Fábio A. de Molfetta. „Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana“. Medicinal Chemistry 16, Nr. 6 (07.09.2020): 784–95. http://dx.doi.org/10.2174/1573406415666190712111139.
Der volle Inhalt der QuelleGao, Dan, Mohamed Madi, Cherlyn Ding, Matthew Fok, Thomas Steele, Christopher Ford, Leif Hunter und Chen Bing. „Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes“. American Journal of Physiology-Endocrinology and Metabolism 307, Nr. 3 (01.08.2014): E289—E304. http://dx.doi.org/10.1152/ajpendo.00430.2013.
Der volle Inhalt der QuelleTakacs, Gregory, Yujia Zhou, David J. King, Amy Meacham, Loguinov Alex, Abderrahmane Tagmount, Amin Sobh, Max Russo, Chris D. Vulpe und Christopher R. Cogle. „CRISPR Dropout Screens Identify DHODH,PIK3C3, and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia“. Blood 134, Supplement_1 (13.11.2019): 1452. http://dx.doi.org/10.1182/blood-2019-128180.
Der volle Inhalt der QuelleRieger, Leonie, Kilian Irlinger, Franziska Fuechsl, Nicolas Barbian, Marlene Tietje, Melanie Faber, Tobias Schulze et al. „Regulation of BCMA By the Ubiquitin Proteasome System Enables Optimization of BCMA-Targeting Therapies in Multiple Myeloma“. Blood 142, Supplement 1 (28.11.2023): 3310. http://dx.doi.org/10.1182/blood-2023-187349.
Der volle Inhalt der QuelleMou, Peipei, Zhao Zeng, Lijie Ren, Qiang Li, Kenneth M. Wannemacher, Xi Mo, Lawrence F. Brass und Li Zhu. „Identification of a Region within the Cytoplasmic Domain of Sema4D That Binds Calmodulin and Regulates Shedding of the Sema4D Exodomain in Platelets“,. Blood 118, Nr. 21 (18.11.2011): 3249. http://dx.doi.org/10.1182/blood.v118.21.3249.3249.
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