Dissertationen zum Thema „Ligaen“
Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an
Machen Sie sich mit Top-50 Dissertationen für die Forschung zum Thema "Ligaen" bekannt.
Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.
Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.
Sehen Sie die Dissertationen für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.
Nandakumar, Jayakrishnan. „Discrimination of RNA versus DNA by an RNA ligase and distinct modes of substrate recognition by DNA ligases /“. Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1428838891&sid=13&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Der volle Inhalt der QuelleFan, Jun. „Investigating the crosstalk between Nedd4 ubiquitin ligases and PIAS3 SUMO ligase“. Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/31791.
Der volle Inhalt der QuelleNakatsubo, Tomoyuki. „Characterization of O-methyltransferases and pinoresinol reductases involved in lignin and lignan biosynthesis“. Kyoto University, 2008. http://hdl.handle.net/2433/123964.
Der volle Inhalt der Quelle0048
新制・課程博士
博士(農学)
甲第14173号
農博第1734号
新制||農||964(附属図書館)
学位論文||H20||N4412(農学部図書室)
UT51-2008-N490
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 梅澤 俊明, 教授 宮川 恒, 教授 矢﨑 一史
学位規則第4条第1項該当
Wang, Shao-Fang. „Biochemical and biophysical studies of MDM2-ligand interactions“. Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9527.
Der volle Inhalt der QuelleLotte, Romain. „Caractérisation des interactions moléculaires entre la GTPase Rac1 et son régulateur HACE1 : perspectives en infectiologie et en cancérologie“. Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4087.
Der volle Inhalt der QuelleThe small GTPase Rac1 plays a key role in various intracellular signaling pathways including cell proliferation. Our laboratory has shown that the CNF1 toxin, produced by pathogenic Escherichia coli, catalyzes the activation of Rac1. We also identified the role of the E3 ubiquitin-ligase HACE1, a tumor suppressor, in the regulation by ubiquitylation of active Rac1. If the activated form of Rac1 is proved to be a target of HACE1, the mode of interaction between these two proteins remains to be define as well as the role of these interactions in infection and cancer. The aim of my work was to characterize the molecular interactions between HACE1 and Rac1. We tested the hypothesis that HACE1 point mutations identified in cancers could interfere with its interaction with Rac1 and its ability to control cell growth. We showed that 13 cancer-associated somatic mutations of HACE1, led to a defective control of cell proliferation. Moreover, the study of these mutations allowed us to identify a group of amino acids, located on the ankyrin-repeats 5 to 7 of HACE1, which controls the interaction of HACE1 with Rac1 and thus its ubiquitylation. We also identified a role for the intermediate domain of HACE1 (MID) in conferring the specificity of association of HACE1 to the active form of Rac1. Ultimately, the characterization of interaction mutants between HACE1 and Rac1 as well as the effect of the CNF1 toxin on this signaling axis will give us more insight on this regulatory pathway in cancer and infection
Lelievre, Chloé. „Formation de liaisons amides par réactions enzymatiques détournées ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase“. Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASF026.
Der volle Inhalt der QuelleThe amide function is widespread in nature and also in many synthetic products such as pharmaceuticals and polymers. Numerous approaches have been developed to provide reliable synthesis methods. The most common approach in conventional chemistry is the acylation of an amine by activated carboxylic acid. Activation requires the use of either coupling reagents resulting in low atom economy, or expensive catalysts sometimes used under drastic conditions. Biocatalytic approaches are therefore interesting alternatives for economic and environmental reasons. Different enzymes can be used such as hydrolases, nitrile hydratases and transglutaminases that activate the acid in acyl-enzyme form to promote the nucleophilic addition of the amine. In recent years, interest in ATP-dependent enzymes has increased.In this project, we focused on CoA ligases that catalyze the formation of activated acid as acyl-adenylate and then acyl-thioester. We have thus demonstrated that by diverting the reaction by scavenging activated intermediate with an amine, we obtain the amide. The use of thermophilic CoA ligases allows us to work at a high temperature and thus facilitate the uncatalyzed addition of the amine. This system therefore dispenses with the use of expensive HSCoA. For a better system, we have also successfully integrated an ATP regeneration system with a Polyphosphate Kinase 2 (Class III) and an inorganic pyrophosphatase. The efficiency of this cascade was illustrated by the lab-scale chemo-enzymatic synthesis of N-methylbutyrylamide in 77 % yield using low enzyme loading.Biodiversity exploration using a genomic approach based on sequence comparison allowed us to identify several thermophilic CoA ligases active towards ω-amino acid substrates. K6Q029 from Thermaerobacter subterraneus was further studied. In particular, this enzyme is active towards ω-amino acid substrates, functionalized or not, with more or less long carbon chains, as well as on various carboxylic acids such as aromatics.Thanks to the structural resolution of A4YDT1, a promiscuous CoA ligase from the literature, we have identified, in collaboration with a team of crystallographers from theUniversity of Groningen (Netherlands), the residues involved in its substrate specificity to modify them by a rational approach. Variants of this enzyme have thus allowed to obtain δ-valerolactam and Ɛ-caprolactam
El, Hachem Najla. „Rôle pro-tumorigénique de HACE1 dans le mélanome“. Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4035.
Der volle Inhalt der QuelleMelanoma incidence has considerably increased over the last thirty years, with a doubling every ten years. Melanoma accounts for only 5% of cutaneous cancers but causes more than 80% of deaths, which is a major public health problem. Indeed, this tumor is extremely aggressive and has a high metastatic potential. After the onset of metastases, the prognosis becomes highly unfavorable. Despite major therapeutic advances, many patients are still refractory to these new treatments. Understanding the mechanisms involved in the development of this tumor and the identification of new therapies remain a major issue. The sequencing of exomes led to the identification of a mutation in the RAC1 gene (P29S) constituting one of the most frequent somatic mutations in melanoma (after the BRAFV600, NRASQ61 and NF1 mutations). RAC1 is a small GTPase that is involved in several key cellular processes. Under physiological conditions, the activity of RAC1 is mainly controlled by GTPase activating proteins (GAPs) and Nucleotide Exchange (GEF) exchange factors. GAPs and GEFs control the level of RAC1- GTP and thus regulate its activity. The activity of RAC1 is also dependent on its protein level of expression which is controlled by E3 ubiquitin ligases, including HACE1. HACE1 is considered a tumor suppressor. Unexpectedly, our data clearly show that HACE1 promotes migratory and tumorigenic properties of melanoma cells. Indeed, inhibition of HACE1 alters migration of melanoma cells in vitro, as well as in vivo pulmonary colonization in mice. Transcriptomic analysis of 4 melanoma cell lines demonstrated that HACE1 suppression inhibits ITGAV and ITGB1 expression
El, Hachem Najla. „Rôle pro-tumorigénique de HACE1 dans le mélanome“. Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4035.
Der volle Inhalt der QuelleMelanoma incidence has considerably increased over the last thirty years, with a doubling every ten years. Melanoma accounts for only 5% of cutaneous cancers but causes more than 80% of deaths, which is a major public health problem. Indeed, this tumor is extremely aggressive and has a high metastatic potential. After the onset of metastases, the prognosis becomes highly unfavorable. Despite major therapeutic advances, many patients are still refractory to these new treatments. Understanding the mechanisms involved in the development of this tumor and the identification of new therapies remain a major issue. The sequencing of exomes led to the identification of a mutation in the RAC1 gene (P29S) constituting one of the most frequent somatic mutations in melanoma (after the BRAFV600, NRASQ61 and NF1 mutations). RAC1 is a small GTPase that is involved in several key cellular processes. Under physiological conditions, the activity of RAC1 is mainly controlled by GTPase activating proteins (GAPs) and Nucleotide Exchange (GEF) exchange factors. GAPs and GEFs control the level of RAC1- GTP and thus regulate its activity. The activity of RAC1 is also dependent on its protein level of expression which is controlled by E3 ubiquitin ligases, including HACE1. HACE1 is considered a tumor suppressor. Unexpectedly, our data clearly show that HACE1 promotes migratory and tumorigenic properties of melanoma cells. Indeed, inhibition of HACE1 alters migration of melanoma cells in vitro, as well as in vivo pulmonary colonization in mice. Transcriptomic analysis of 4 melanoma cell lines demonstrated that HACE1 suppression inhibits ITGAV and ITGB1 expression
Orts, Julien. „Caractérisation des interactions entre ligands et protéines par RMN en solution“. Grenoble, 2010. http://www.theses.fr/2010GRENY011.
Der volle Inhalt der QuelleIn the process of structure-based drug design, the provision of the binding mode of ligands to the cellular receptor of interest is essential. This can suffer from limited access to protein/ligand structures, especially for the low affinity ligands that are commonly obtained from high throughput screening or fragment based lead discovery. In a common scenario crystal structures are available for one or several ligands but not for all chemical series of actual interest. Here, we present a new, NMR-based approach that allows overcoming this limitation. In the INPHARMA method interligand NOEs (Nuclear Overhauser Enhancement) are utilized to determine relative orientations of different chemical fragments binding competitively to a common receptor site. This novel methodology opens the way to the application of structure-based drug design already in an early stage of drug development, when structural information via crystallography is of difficult access
Gupta, S. K. „Isolation, cloning and characterization of lignin biosynthesis pathway gene(s) 4-coumarate co a ligase (4cl) from leucaena leucocephala“. Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2008. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2705.
Der volle Inhalt der QuelleNdo, Gaetan. „Etude et optimisation de techniques de réduction de bruit impulsif pour transmissions haut débit sur lignes à courants porteurs en contexte résidentiel“. Télécom Bretagne, 2010. http://www.theses.fr/2010TELB0153.
Der volle Inhalt der QuelleThis thesis aims at improving some asynchronous impulsive noise reduction techniques for broadband transmissions over indoor power lines. Indeed, beside the particular physical properties of this type of medium, asynchronous impulsive noise remains one of the main causes of performance degradation in powerline communications (PLC). Such an impairment is usually coped with retransmission strategies at the price of a spectral efficiency loss. Although several other countering strategies are proposed in the literature, only very few of them exhibit a reasonable complexity. In particular, the clipping and the blanking approaches present a very good trade-off between the impulsive noise mitigation and the complexity of the implementation. In this thesis, an optimization of the threshold determination, which is usually empirically done, is performed analytically both for the clipping and the blanking non-linearities. Moreover, some adaptive receiver structures for asynchronous impulsive noise reduction over PLC are proposed. On the other hand, because of its good frequency selectivity features and its spectral efficiency gain compared to cyclic-prefix OFDM (CP-OFDM), the OFDM/Offset QAM (OFDM/OQAM) can be seen as an alternative multicarrier modulation scheme for transmission over power lines. Since no study was dedicated to analyze such a modulation in an impulsive environment, this thesis investigates the performance behavior of an OFDM/OQAM modulated system corrupted by asynchronous impulsive noise. Furthermore, a thorough Log-Likelihood Ratio (LLR) computation is derived for coded OFDM/OQAM transmissions under realistic PLC conditions, and the performance results are compared with those obtained with coded CP-OFDM. Finally, a new diversity of the OFDM/OQAM modulation is pointed out in this work
Villa, Elodie. „Échapper à la mort cellulaire dans le cancer : mitophagie et régulation de la mort indépendante des caspases“. Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4109.
Der volle Inhalt der QuelleOne of the hallmarks of tumor cells is their ability to escape cell death.To achieve this, they have developed a strategy of selectively removing damaged mitochondria by a process of mitophagy. The main actor of mitophagy is the ubiquitin ligase Parkin; but it is mutated or absent in the majority of cancers. We have discovered that another ligase, ARIH1, belonging to the same family of RBR ligases as Parkin, is capable of inducing mitophagy in response to stress. In contrast to Parkin, ARIH1 is overexpressed in many cancers, especially in lung cancer, allowing an increase in mitophagy conferring resistance to stress induced by chemotherapeutic agents. The most characterized cell death pathway is apoptosis, which is directly related to caspases activation. However, it has been established, that caspase inhibition does not prevent cell death because there is another type of cell death called "caspase-independent cell death" or CICD. However, its precise molecular definition is still unknown. Thus for this purpose, pan-genomic siRNA screening was performed and revealed the importance of the ubiquitin / proteasome pathway. In particular, we have been able to identify an enzyme E3 ligase as being protective towards CICD. This enzyme is overexpressed in many cancers and could allow cancer cells to resist CICD and promote tumor progression. In summary, this work has highlighted the importance of ubiquitin ligases in the escape mechanisms to cell death implemented by cancer cells
Thaler, Sebastian. „In vitro-Interaktion der E3-Ubiquitin-Ligase HectH7 mit dem potentiellen Tumorsuppressor CDX2 und Herstellung aufgereinigter polyklonaler Antikörper gegen HectH7 /“. Berlin : Logos Berlin, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2662618&prov=M&dok_var=1&dok_ext=htm.
Der volle Inhalt der QuelleRibau, Humberto Miranda. „Soldadura laser pulsado Nd: YAG entre metais dissimulares“. Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/23358.
Der volle Inhalt der QuelleA presente investigação consiste no estudo experimental das propriedades mecânicas induzidas pela soldadura laser em chapas de materiais metálicos dissimilares, nomeadamente, aço de alta resistência dual-phase (DP) 600 com aço de alta resistência dual-phase (DP) 1000 e liga de alumínio AA6060-T6 com liga de titânio Ti-6Al-4V. No caso dos aços dual-phase, o estudo foi realizado em amostras de 0,8 mm de espessura, numa junta do tipo topo a topo. Após a seleção dos parâmetros mais adequados para a soldadura, foram efetuados ensaios de tração aos provetes soldados, com o objetivo de determinar as propriedades mecânicas e avaliar a influência dos parâmetros do laser. Em relação à ligação de alumínio com titânio, esta foi feita numa junta de sobreposição dupla em amostras de 1,9 e 0,9 mm de espessura, respetivamente. Do mesmo modo que os aços, foram também variados os parâmetros do laser, de modo a se obter os mais adequados, para posteriormente se efetuar ensaios de tração. Variou-se também o sítio onde o feixe laser incide na junta de sobreposição para melhor avaliar a soldadura.
The aim of this thesis consists of an experimental study of the mechanical properties induced by the laser welding in dissimilar metal, namely, dual-phase steel 600 with dual-phase steel 1000 and aluminium alloy AA6060-T6 with titanium alloy Ti-6Al-4V. In the case of the dual-phase steels, the study was carried out on 0,8 mm plates, in a butt joint type. After selecting the most appropriate parameters for the welding, tensile tests were performed on welded specimens with the purpose to find the mechanical properties and evaluate the influence of the laser parameters. The aluminium - titanium union was accomplished on a double-lap joint on 1,9 mm and 0,9 mm plates, respectively. Just like the situation of the steels, the laser parameters were too varied with aim to obtain the most appropriate parameters, to later perform tensile tests. It was also changed the place where the laser beam impacts on the specimen, to better analyse the welding.
Wang, Peter Tien Chun. „Role and regulation of Gp78 E3 ubiquitin ligase and its ligand autocrine motility factor in mitochondrial dynamics and mitochondria-endoplasmic reticulum association“. Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54246.
Der volle Inhalt der QuelleMedicine, Faculty of
Graduate
Chai, Jianfang. „Synthesis, structure and reactivity of manganese complexes supported by carbon or nitrogen donor ligands“. Doctoral thesis, [S.l. : s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/chai/chai.pdf.
Der volle Inhalt der QuellePautler, Mark F. „The impediment of ligamen in multiple marriages“. Theological Research Exchange Network (TREN), 2005. http://www.tren.com.
Der volle Inhalt der QuelleMadikane, Mzekelo. „Biosulphidogenic hydrolysis of lignin and lignin model compounds“. Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003976.
Der volle Inhalt der QuelleBetts, Walter B. „Microbial degradation of lignin and lignin related aromatic compounds“. Thesis, Loughborough University, 1987. https://dspace.lboro.ac.uk/2134/12210.
Der volle Inhalt der QuelleGalkin, Maxim. „Palladium-catalyzed lignin valorization : Towards a lignin-based biorefinery“. Doctoral thesis, Uppsala universitet, Syntetisk organisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265315.
Der volle Inhalt der QuelleWang, Yu. „Mismatch ligation during non-homologous end joining pathway kinetic characterization of human DNA ligase IV/XRCC4 complex /“. Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1179947467.
Der volle Inhalt der QuelleLotte, Romain. „Caractérisation des interactions moléculaires entre la GTPase Rac1 et son régulateur HACE1 : perspectives en infectiologie et en cancérologie“. Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4087/document.
Der volle Inhalt der QuelleThe small GTPase Rac1 plays a key role in various intracellular signaling pathways including cell proliferation. Our laboratory has shown that the CNF1 toxin, produced by pathogenic Escherichia coli, catalyzes the activation of Rac1. We also identified the role of the E3 ubiquitin-ligase HACE1, a tumor suppressor, in the regulation by ubiquitylation of active Rac1. If the activated form of Rac1 is proved to be a target of HACE1, the mode of interaction between these two proteins remains to be define as well as the role of these interactions in infection and cancer. The aim of my work was to characterize the molecular interactions between HACE1 and Rac1. We tested the hypothesis that HACE1 point mutations identified in cancers could interfere with its interaction with Rac1 and its ability to control cell growth. We showed that 13 cancer-associated somatic mutations of HACE1, led to a defective control of cell proliferation. Moreover, the study of these mutations allowed us to identify a group of amino acids, located on the ankyrin-repeats 5 to 7 of HACE1, which controls the interaction of HACE1 with Rac1 and thus its ubiquitylation. We also identified a role for the intermediate domain of HACE1 (MID) in conferring the specificity of association of HACE1 to the active form of Rac1. Ultimately, the characterization of interaction mutants between HACE1 and Rac1 as well as the effect of the CNF1 toxin on this signaling axis will give us more insight on this regulatory pathway in cancer and infection
Schulz, Christoph [Verfasser], und Ingo [Akademischer Betreuer] Krossing. „Novel conducting salts for rechargeable lithium-ion batteries based on the difluorophosphato ligand = Neuartige Leitsalze für Lithium-Ionen Akkumulatoren basierend auf dem Difluorphosphat-Liganden“. Freiburg : Universität, 2014. http://d-nb.info/1123480400/34.
Der volle Inhalt der QuelleVilla, Elodie. „Échapper à la mort cellulaire dans le cancer : mitophagie et régulation de la mort indépendante des caspases“. Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4109.
Der volle Inhalt der QuelleOne of the hallmarks of tumor cells is their ability to escape cell death.To achieve this, they have developed a strategy of selectively removing damaged mitochondria by a process of mitophagy. The main actor of mitophagy is the ubiquitin ligase Parkin; but it is mutated or absent in the majority of cancers. We have discovered that another ligase, ARIH1, belonging to the same family of RBR ligases as Parkin, is capable of inducing mitophagy in response to stress. In contrast to Parkin, ARIH1 is overexpressed in many cancers, especially in lung cancer, allowing an increase in mitophagy conferring resistance to stress induced by chemotherapeutic agents. The most characterized cell death pathway is apoptosis, which is directly related to caspases activation. However, it has been established, that caspase inhibition does not prevent cell death because there is another type of cell death called "caspase-independent cell death" or CICD. However, its precise molecular definition is still unknown. Thus for this purpose, pan-genomic siRNA screening was performed and revealed the importance of the ubiquitin / proteasome pathway. In particular, we have been able to identify an enzyme E3 ligase as being protective towards CICD. This enzyme is overexpressed in many cancers and could allow cancer cells to resist CICD and promote tumor progression. In summary, this work has highlighted the importance of ubiquitin ligases in the escape mechanisms to cell death implemented by cancer cells
Schulman, Cheryl Lutins. „Synthesis, Structure, and Solution Dynamics of Co₄(CO)₈(dmpe)(mu₄-PPh)₂“. Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc501095/.
Der volle Inhalt der QuelleTouzé, Elodie Giegé Richard. „Cristallogenèse et études structurales appliquées aux aminoacyl-ARNt synthétases“. Strasbourg : Université Louis Pasteur, 2008. http://eprints-scd-ulp.u-strasbg.fr:8080/911/01/TOUZE_Elodie_2007.pdf.
Der volle Inhalt der QuelleANSELMO, George Carlos dos Santos. „Processo e caracterização de ligas Ti-Ni-Cu com efeito de memória de forma solidificadas rapidamente“. Universidade Federal de Campina Grande, 2014. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/345.
Der volle Inhalt der QuelleMade available in DSpace on 2018-04-06T20:54:52Z (GMT). No. of bitstreams: 1 GEORGE CARLOS DOS SANTOS ANSELMO - TESE PPG-CEMat 2014..pdf: 19735821 bytes, checksum: c92e61b342c27548f43bd01d30640a96 (MD5) Previous issue date: 2014-08-29
Ligas com efeito de memória de forma possuem grande potencial para aplicações nos setores da robótica, automotivo, aeronáutico, medicina e na produção de atuadores miniaturizados. O objetivo desse trabalho foi investigar e desenvolver materiais com efeito de memória de forma (Shape Memory Effect - SME) das ligas Ti-Ni-Cu na forma de fitas micrométricas produzidos por meio de Melt Spinning. A metodologia utilizada para produção das ligas Ti-Ni-Cu foi via fusão a plasma (Plasma Skull Push-Pull), e para fabricação de fitas utilizou-se a técnica de solidificação rápida por injeção de metal líquido em volante de cobre nas velocidades de 38 e 50 m/s, logos após as ligas e fitas Ti-Ni-Cu foram caracterizadas por: DSC, SMRT, DRX, MEV. Inicialmente barras prismáticas da liga Ti-Ni50-x-Cux (x=3,4,5,6,7%at.Cu) foram produzidas via fusão a plasma. Por meio solidificação rápida obteve-se fitas com espessuras de 30 a 45 µm com a variação da velocidade do volante de cobre de 38 e 50 m/s no Melt Spinning. Ensaios de DRX revelam à presença da fase B19’ nas ligas brutas de fusão a temperatura ambiente. As ligas apresentaram transformações de fase em único estágio B2↔B19`. As temperaturas de transformação As das ligas Ti-Ni-Cu decrescem com o incremento de Cu. Concluise que as temperaturas de transformação martensíticas (Ms) de fitas Ti-Ni-Cu decrescem com a diminuição do tamanho de grão, e os valores de histerese e entalpia decrescem quando altas taxas de super-resfriamento são alcançadas no Melt Spinnig.
Alloys with shape memory effect have immense potential for applications in robotics, automotive and aeronautics industry, medicine and in the production of miniaturized actuators. The aim of this study was to investigate, develop and manufacture materials with shape memory effect of Ti-Cu-Ni alloys in the form of micrometer tapes produced by Melt Spinning. The methodology used for the production of Ti-Cu-Ni alloys by fusion plasma (Plasma Skull Push-Pull), and manufacturing tapes used the technique of rapid solidification injection of liquid metal into the copper wheel speeds 38 and 50 m/s. alloy and Ti-Ni-Cu ribbons were characterization by: DSC, SMRT, XRD, SEM. Initially prismatic bars of Ti-Ni50-x-Cux (x = 3,4,5,6,7 at.Cu%) had been produced by plasma fusion. With the rapid solidification is obtained tapes with thicknesses between 30 to 45 µm with the variation of the speed of the wheel covers 38 and 50 m / s the melt spinning. XRD tests reveal the presence of the B19' in gross phase alloy melting temperature. The alloys showed phase transformations in single stage B2↔B19`. The transformation temperatures of the alloy Ti-Cu-Ni decrease with the increase of Cu. We conclude that the temperatures of martensitic transformation (Ms) of Ti-Ni-Cu ribbons decreases with decreasing grain size, and hysteresis values and enthalpy decreases when high rates of super-cooling are achieved in Melt Spinnig.
Bach, Jason Samuel. „Design and evaluation of a prosthetic anterior cruciate ligament replacement medical device“. Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47580.
Der volle Inhalt der QuelleJohal, Amrit. „Chemicals from lignin“. Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716671.
Der volle Inhalt der QuelleWade, R. C. „Ligand-macromolecule interactions“. Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:576ce119-6a93-4eb0-a7e4-1f2513736dbd.
Der volle Inhalt der QuellePeberdy, Jemma C. „Biomacromolecule-ligand interactions“. Thesis, University of Warwick, 2004. http://wrap.warwick.ac.uk/4069/.
Der volle Inhalt der QuelleKontopidis, George A. „Immunophilin ligand design“. Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22386.
Der volle Inhalt der QuelleKvainauskas, Darius, und Martin Johansson. „Biodrivmedel från lignin“. Thesis, KTH, Skolan för industriell teknik och management (ITM), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232835.
Der volle Inhalt der QuelleLignin is a molecule found in all plants and can be used to produce new generation biofuels. Lignin-based biofuels are beneficial from an environmental aspect because they help to reduce the greenhouse effect, but also because the extraction of black liquor can streamline the production of pulp. In the manufacturing process of pulp, a residual product is obtained by the name of black liquor. Black liquor has a high energy content and can be quite difficult to handle after extraction. It can be used for heat or energy internally in the pulp mill, but it is often available in larger quantities than infrastructure at the pulp- and paper mills can handle. It is from black liquor that lignin can be extracted. Today, there are processes such as LignoBoost that extract lignin from black liquors. The lignin then needs to be converted into a liquid form and then mixed as a component of gasoline and diesel. This Bachelor's Degree Project explores the possibilities of using black liquor and making ligninbased biofuels. In addition, the entire raw material flow of lignin has been mapped. The mapping of the raw material flow has been carried out using a literature study and interviews. Furthermore, estimates have been made of how much of the energy consumption in the transport sector that can be replaced by the energy that is obtainable from lignin. The energy potential of the lignin is based on three different cases, with different proportions of available lignin. For Case 2, where 50% of the lignin is recovered, the cost of a replacement source (wood chips) is also calculated. This energy source can replace the energy in black liquor that is used as fuel in the pulp- and paper mills. From the literature study and the interviews, it is concluded that there is currently no raw material flow for lignin, but there are three steps that need to work together to create a functioning one; recovery of lignin, conversion into liquid lignin and distribution to consumers. All stakeholders in this raw material flow need to work together to find a solution everyone can benefit from and subsidies may be needed for the fuel to have a reasonable price. The result shows that there are 3.1 million tonnes of lignin available for one year from pulp and paper mills in Sweden. From this lignin the energy potential is 12.81 TWh if it is assumed that 30% of all black liquor is used, which is equivalent to the energy used by 1.56 million cars. This corresponds to 13.6% of the energy demand in the transport sector. If 50% of the black liquor is used, the energy potential is 21.34 TWh, which corresponds to 22.7% of the energy demand in the transport sector. In this case, 25 million tons of wood fuel would need to be used to replace energy, which costs 1.56 billion SEK.
Delance, Cécile. „Analyse des mécanismes assurant la robustesse d’un événement de transdifférenciation : rôle de l’ubiquitine ligase E3 SEL-10“. Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ027.
Der volle Inhalt der QuelleDifferentiated cells can change their cellular fate induced or naturally. In order to understand the mechanisms controlling reprogramming processes, our laboratory is studying the natural change in identity (or transdifferentiation, Td) of a rectal epithelial cell (named Y) and motor neuron (named PDA) in Caenorhabditis elegans.Preliminary work has shown that there is a synergy between histone modifications (jmjd-3.1 and wdr-5.1) and ubiquitination (sel-10). SEL-10 is an E3 ubiquitin ligase with a Fbox domain and WD40 repeat domain.In this study, we highlight: i) the Fbox domain involvement in the Td, indications about the intracellular localization of SEL-10 and an unexpected role of the proteasome within TD. ii) a role of SEL-10 in the robustness of the Td. iii) sel-10, jmjd-3.1 and wdr-5.1 act on gene transcription in transdifferentiation. This one was tested by smFISH and allowed the characterization of the cog-1 transdifferentiation marker expression pattern during redifferentiation
Deeth, R. J. „Redirected ligand-field analysis : applications of the cellular ligand-field model“. Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355257.
Der volle Inhalt der QuelleFreundlich, Joel Stephen. „Metal-ligand multiple bonds in organometallic complexes containing triamidoamine ligand systems“. Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/38782.
Der volle Inhalt der QuelleJackson, Alicia M. „Investigation of the ligand shells of homo-ligand and mixed-ligand monolayer protected metal nanoparticles : a scanning tunneling microscopy study“. Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39548.
Der volle Inhalt der QuelleIncludes bibliographical references.
Monolayer Protected Metal Nanoparticles have recently found widespread use in and are the focus of intensive study in many areas of scientific research ranging from biology to physics to medicine. Consisting of a nanoscale, crystalline, metallic core surrounded by a self-assembled monolayer of ligands (a 3-D SAM or ligand shell), their appeal and utility stem from their numerous unique properties-many of which arise and are modulated by the intimate spatial and electronic contact between core and shell. The ligand shell controls the particle's interactions with its environment (e.g. sensing, assembly, and electron transfer ability). Furthermore, the ability to manipulate and assemble such nanomaterials through the ligand shell is paramount to their incorporation into and the development of new nanoparticle based materials and devices. However, little is known of the exact composition and packing arrangements of molecules within the ligand shell, and even less so on how to control the resulting nanostructuring. In this thesis we present a Scanning Tunneling Microscopy investigation of the ligand shells of homo- and mixed-ligand metal nanoparticles.
(cont.) We develop an understanding and model of the ligand arrangements around the nanoparticle core, showing that the multifaceted, high curvature, and topologically spherical nature of the core results in a 3-D SAM that has many differences from its 2-D SAM counterparts. We show that the core curvature (and correspondingly, the changing facet to edge ratio on the core surface) of the particles is the dominant driver for the packing and behavior of the ligand shell. Most interestingly, we find that when certain two-component, mixed SAMs are assembled around the particle core, the ligands phase-separate into ordered, ribbon-like domains, only a few molecules in width-a behavior never before seen on flat surfaces. We show that both the domain morphology and width can be controlled through the ligand shell composition and the particle core size, and that the observed phase-separation is a general phenomenon across nanoparticle compositions. We present these studies as a first step towards developing a complete model of and control over the ligand shell structure of nanoparticles.
by Alicia M. Jackson.
Ph.D.
Auguste, Tiphanie. „Implication de ROQUIN dans la physiopathologie du lymphome T angio-immunoblastique“. Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0076.
Der volle Inhalt der QuelleImplication of ROQUIN in the physiopathology of angio-immunoblastic T cell lymphoma. AITL is a peripheral T cell lymphoma, poorly studied compared to B cell lymphomas due to its rarity. In France, AITL is the PTCL the most frequently encountered. Despite a variable clinical course, AITL is an aggressive tumor with an overall survival lower than 3 years. One of our goal is to better understand the physiopathology of this lymphoma and identify oncogenic events that lead to its development. In this project, our study was focused on ROQUIN gene that encodes a RING E3 ubiquitin ligase and whose mutation induces an AITL-like syndrom in sanroque mice.Although we did not detect any mutation in ROQUIN coding sequence, we identified a novel alternative transcript referred as ROQUIN ØE17. It encodes a protein that, like wild type protein, localizes to stress granules and P bodies and interacts with mRNAs and microRNAs. However, only ROQUIN ØE17 inhibits the expression of the costimulatory molecule ICOS. This transcript, whose expression varies between T cell populations, is hardly expressed in AITL. Consequently, the loss of ROQUIN ØE17 could be involved in the genesis and/or development of this lymphoma
Schupp, Michael. „Identifizierung und Charakterisierung von AT1-Antagonisten als PPAR[gamma]-Liganden [PPARgamma-Liganden]“. [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/134/index.html.
Der volle Inhalt der QuellePetrescu, Anca Daniela. „Ligand binding proteins: roles in ligand transfer and activation of nuclear receptors“. Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/290.
Der volle Inhalt der QuelleDodson, A. P. J. „The use of lignin peroxidases to degrade lignin in plant cell walls“. Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46747.
Der volle Inhalt der QuelleTan, Xin. „Effect of Organosolv Lignin and Extractable Lignin on Enzymatic Hydrolysis of Lignocelluloses“. University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613752000022518.
Der volle Inhalt der QuelleJennings, John Adam. „HETEROGENEOUS BASE METAL CATALYZED OXIDATIVE DEPOLYMERIZATION OF LIGNIN AND LIGNIN MODEL COMPOUNDS“. UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/81.
Der volle Inhalt der QuelleDodge, Luke A. „FRACTIONATION OF LIGNIN DERIVED COMPOUNDS FROM THERMOCHEMICALLY PROCESSED LIGNIN TOWARDS ANTIMICROBIAL PROPERTIES“. UKnowledge, 2018. https://uknowledge.uky.edu/bae_etds/54.
Der volle Inhalt der QuelleBourgeois, Yannick. „Modélisation des perturbations électromagnétiques générées sur un réseau de télécommunications par une agression de type foudre“. Limoges, 2009. https://aurore.unilim.fr/theses/nxfile/default/ecc54aba-2824-4378-9858-a6928f3bb547/blobholder:0/2009LIMO4004.pdf.
Der volle Inhalt der QuelleLightning by its direct and indirect effects may engender important damages on a telecommunications network. This thesis approaches the modeling of the coupling of a lightning stroke with a structure composed of a building associated to a wired network. By means of a formalism based on the transmission line theory associated to a topological approach, a study of the efficiency of a lightning protection device, composed of a shielding wire installed in the ground above the underground cable, is made in a exhaustive way by using experimental data obtained by means of triggered lightning. Furthermore, thanks to the antenna theory in the time domain (FDTD), the thesis also approaches the calculation of the currents generated simultaneously on a building and its wired network when the lighting stroke occurs on the considered structure. The practical application aimed by all these works being the improvement of the lightning protection of the radio-sites
Labisch, Oliver. „Offenkettige Monosaccharide als Liganden“. Diss., [S.l.] : [s.n.], 2006. http://edoc.ub.uni-muenchen.de/archive/00006050.
Der volle Inhalt der QuelleLuo, Jie. „Lignin-Based Carbon Fiber“. Fogler Library, University of Maine, 2010. http://www.library.umaine.edu/theses/pdf/LuoJ2010.pdf.
Der volle Inhalt der QuelleNguyen, Nhung Phuong. „Axial ligand mutant H229A /“. unrestricted, 2007. http://etd.gsu.edu/theses/available/etd-08082008-134926/.
Der volle Inhalt der QuelleTitle from file title page. Under the direction of Dabney White Dixon. Electronic text (88 p. : col. ill.) : digital, PDF file. Description based on contents viewed Sept. 30, 2008. Includes bibliographical references (p. 46-47).
Nguyen, Nhung Phuong. „Axial Ligand Mutant: H229A“. Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/honors_theses/1.
Der volle Inhalt der QuelleBrown, C. A. „Ligand field spectral intensities“. Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377247.
Der volle Inhalt der Quelle