Dissertationen zum Thema „Lactams“
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Betou, Marie. „Semipinacol rearrangement of cis-fused β-lactam diols into bicyclic lactams“. Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4348/.
Warren, H. A. „New routes to sugar lactams, lactim ethers and cyclic amidines“. Thesis, Swansea University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639351.
Guignard, Guillaume Michel Pablo. „Open-chain building blocks from chiral lactams. Enantioselective synthesis of macrocyclic nitrogen-containing natural products“. Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396650.
Sheppard, L. N. „Synthesis of B-lactams“. Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354855.
McKenna, Jeffrey M. „Asymmetric synthesis of #beta#-lactams“. Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240681.
Goh, Kee Chuan. „The biosynthesis of β-lactams“. Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:24b6b29d-87cc-48f2-bd1b-bb64c663604f.
Welchman, Elizabeth Victoria. „The chemistry of β lactams“. Thesis, University of Sunderland, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247775.
Walker, Matthew David. „Diastereoselective reactions of atropisomeric lactams“. Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247569.
Pearson, C. J. „Synthesis of aza-beta-lactams“. Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37815.
Pérez, Bosch Maria. „Addicions conjugades a lactames bicícliques derivades del fenilglicinol: síntesi enantioselectiva de piperidines 3,4- i 3,4,5-substituïdes“. Doctoral thesis, Universitat de Barcelona, 2002. http://hdl.handle.net/10803/673099.
Wallace, P. M. „Approaches to synthesis of beta-lactams“. Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355808.
Jones, Mark. „The enzyme catalysed formation of lactams“. Thesis, University of Huddersfield, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293346.
Nadin, Alan. „Medium ring lactams as peptidic constraints“. Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272640.
Shah, Ajit Jesang. „The analysis of #beta#-lactams and their biosynthetic intermediates in fermentations of #beta#-lactam producing fungi“. Thesis, University of Westminster, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358855.
Derrer, Sam. „Medium ring lactams as peptide conformational constraints“. Thesis, University of Cambridge, 1998. https://www.repository.cam.ac.uk/handle/1810/251637.
Virden, Jane. „Chemical and enzymatic synthesis of #beta#-lactams“. Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253475.
Dixon, Rachel Anne. „Asymmetric reduction of meso-imides and lactams“. Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399101.
Khaled, Arwa M. „Heterometallic complexes with lactams and related ligands“. Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46864.
Kenwright, Jayne Louise. „Synthesis of medium ring amines and lactams“. Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608700.
Philippe, Jules. „Pneumococcus morphogenesis and resistance to beta-lactams“. Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV018/document.
Streptococcus pneumoniae, the pneumococcus, is a bacterial pathogen that causes more than 1.5 million deaths each year in the world. β-Lactams are widely used to treat patients with pneumococcal infections. These antibiotics inhibit the synthesis of the peptidoglycan, a giant molecule constituting a mesh of aminosugar strands encasing the cell. This main constituent of the cell wall allows cells to maintain their integrity under the turgor pressure, and endows bacteria with their shape. The action of β-lactams is well understood from a biochemical point of view. However, a complete understanding of the physiological response of treated bacteria remains elusive. In this thesis, I investigated the molecular mechanisms of the morphogenesis of S. pneumoniae using methods of biochemistry and microbiology. A morphogenesis model is built based on my results and the literature, which permits to emit hypotheses concerning the response of the pneumococcus to β-lactams
Micheli, Bernard Jean Marie. „NMR studies of dimeric and polymeric lactams“. Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185270.
Westwood, Nicholas James. „Synthetic and mechanistic studies on the inhibition of elastases“. Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306872.
Shakya, Sagar Raj. „Studies on alpha,alpha-disubstituted bicyclic beta-lactams“. Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7571.
Kang, T. W. „Novel synthesis of #beta#-lactams via radical pathways“. Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379970.
Goswami, Rajesh. „Bicyclic lactams for the synthesis of functionalised heterocycles“. Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365826.
Gardiner, James. „Conformationally restricted amino acid analogues based on lactams“. Thesis, University of Canterbury. Chemistry, 1998. http://hdl.handle.net/10092/8773.
Pink, Jennifer Helen. „Synthesis of fused lactams via N-acyliminium ions“. Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242373.
Ajavakom, Anawat. „Novel radical based routes to pyrrolidine trans lactams“. Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288468.
Fontana, Francesco. „Stereoselective synthesis of β-lactams and carpanone derivatives“. Paris 6, 2008. http://www.theses.fr/2008PA066441.
Naz, Summia. „A calorimetric study of β-sultams and β-lactams“. Thesis, University of Huddersfield, 2009. http://eprints.hud.ac.uk/id/eprint/6975/.
Baugh, Simon Peter. „Alkene metathesis in the synthesis of novel #beta#-lactams“. Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300539.
Bahajaj, Abood Ahmed. „Asymmetric synthesis of spiro lactams via n-acyliminium ions“. Thesis, University of York, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241062.
Brown, Giles A. „The azomethine ylide approach to novel bicyclic #beta#-lactams“. Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302062.
Jackson, Lynn. „Inhibition of elastase and trypsin by novel β-lactams“. Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/15094.
Ghirardi, Elena. „Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis“. Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398789.
El primer objetivo de esta Tesis Doctoral ha sido el estudio de la preparación de octahidro-1H-ciclopentapiridinas y octahidro-1H-indoles, a través de la síntesis de lactamas tricíclicas derivadas del (R)-fenilglicinol. Desafortunadamente, la reacción del ceto-éster 4 y del ceto-ácido 7, proporcionó solamente las eniminas 8 y 9. Por otro lado, la reacción de los derivados de ceto-ácidos 16 y 17 con (R)-fenilglicinol rindió únicamente una mezcla de productos 18, amidas conjugadas epímeras en la posición C-7a. Se ha sido estudiado la reacción de ciclocondensación de derivados de 2-oxociclohexano propionato convenientemente sustituidos en C-3 o en C-3 y C-5 con (R)-fenilglicinol y (1S,2R)-aminoindanol. Esta reacción conduce estereoselectivamente a lactamas tricíclicas o pentacíclicas quirales: se aisló mayoritariamente una lactama y se detectó la presencia de otra minoritaria. Al utilizar (1S,2R)-aminoindanol se obtuvieron mejores resultados. Estas lactamas son precursoras de cis-decahidroquinolinas, con sustituyentes en la posición 8 o en la posición 6 y 8. Las etapas clave de esta transformación son la reducción con alano y la eliminación del inductor quiral. Con esta metodología se ha preparado la decahidroquinolina 82, precursor de numerosos alcaloides de la familia Mirioneuron nutans. Además, presentamos el estudio de las reacciones de ciclocondensación con (R)-fenilglicinol a partir de ciclohexanonas que poseen una cadena de acetato en la posición C-1 y diversos sustituyentes alquilo o arilo en la posición C-3. Esta reacción conduce estereoselectivamente a una sola lactama tricíclica de las ocho posibles. A partir de las cetonas con un sustituyente alquilo en la posición C-3 aislamos una cantidad variable de enamida. Las lactamas mayoritarias, fueron convertidas en cis-octahidroindoles y cis-octahidroindolonas, que presentan un sustituyente en la posición 7 o en las posiciones 7 y 7a del anillo carbocíclico. Además, estudiamos la reactividad de las lactamas tricíclicas en medio ácido: la reacción con TiCl4 en THF, proporciona lactamas insaturadas con elevada estereoselectividad y buen rendimiento. La presencia de la función enamida, nos permitió preparar selectivamente nuevas cis y trans octahidroindolonas. Esta metodología nos permitió sintetizar el (a)-Licorano, un metabolito de la familia de las Amaryllidaceae.
Karstens, Willem Frederik Johan. „Palladium-catalyzed cyclization reactions of allene- and acetylene-substituted lactams“. [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/83628.
Houson, I. N. „Ring expansions in the synthesis of di- and tri-lactams“. Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390511.
Rahman, Adrian. „The synthesis of new tricyclic beta lactams based upon quinoline“. Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366356.
Thomas, Russell John. „The synthesis of novel #beta#-lactams with potential antifungal activity“. Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277147.
Skytte, Dorthe. „Antimalarial norneolignans, synthesis and SAR & synthesis of beta-lactams /“. Cph. : Danish University of Pharmaceutical Sciences, Department of Medicinal Chemistry, 2005. http://www.dfuni.dk/index.php/Dorthe_Mondrup_Skytte/2238/0/.
André, Marcelo Fabiano 1978. „Sintese de B-piperonil-y-butirolactona e B-lactamas utilizando reações de Morita-Baylis-Hillman“. [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250241.
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
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Resumo: As b-piperonil-g-butirolactonas são intermediários importantes, tendo em vista que a partir delas é possível dar origem a uma série de lignanas, classe de substâncias de grande interesse científico, por apresentarem diversas atividades biológicas, tais como: antiretroviral, antitumoral, antimalárica, entre outras. Neste trabalho realizamos estudos visando melhorar a diastereosseletividade na preparação de g-butirolactonas com estereoquímica relativa trans, já que a cis já era preparada com boa diastereosseletividade em nosso laboratório. A metodologia desenvolvida baseia-se na redução de um b-ceto-éster obtido a partir da oxidação de um a-ciano-metil-b-hidroxi-éster, este último obtido com um bom rendimento a partir de uma reação de adição de Michael sobre um aduto de Morita-Baylis-Hillman ( MBH). Na segunda parte do trabalho preparamos b-amino-ésteres a partir dos adutos de Morita-Baylis- Hillman (MBH). Utilizamos como estratégia uma reação de adição do tipo Michael com várias aminas. Os b-amino-ésteres foram obtidos com rendimentos variando de 78-93%. Os produtos foram caracterizados e a estereoquímica relativa foi determinada, por nOe, através da formação de um intermediário oxazinanona. Esses b-amino-ésteres são importantes intermediários para a síntese de heterociclos, tais como b-lactamas e oxazinanonas funcionalizadas.
Abstract: The b-piperonil-g-butirolactones are important synthetic intermediates, since they can be used as substrates for the synthesis of different type of lignans, a class of substances of great scientific interest. Lignans exhibit relevant biological activites, as anti-tumoral, anti-retroviral, anti-malarial, etc. In this work, studies have been carried out aiming at improving the diastereoselectivity for the preaparation of butirolactones having anti relative stereochemistry. A method to synthesize g-butirolactone have already been established in our laboratory. The methodology used was based on the the stereoselective reduction of a b-ketoester prepared from the oxidation of a a-cyanomethyl-b-hydroxy-ester. The latter was promptly prepared, in good yields, from a cyanide 1,4 addition over the double bond of Morita-Baylis-Hillman (MBH) adducts. In the second part of this work, we have prepared several b-amino-esters from Morita-Baylis- Hillman (MBH) adducts. The strategy was based also on a Michael addition of different amines over the double bond of MBH adducts. The b-amino-esters were obtained in good yield. Their stereochemistries were determined by nOe experiments of the corresponding oxazinanones. These b-amino-esters are important intermediates for the synthesis of heterocycles, as b-lactams and functionalized oxazinanones.
Mestrado
Quimica Organica
Mestre em Química
Bhattacharya, Biplob. „Synthesis and Anti-MRSA Activity of Hydrophilic C3-Acylated N-Thiolated β-Lactams and N-Acyl Ciprofloxacin-N-Thiolated β-Lactam Hybrids“. Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4289.
Balko, Tamara. „Characterization of the inoculum effect with Haemophilus influenzae and ß-lactams“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23211.pdf.
Heaney, V. J. „The synthesis and biological activity of monocyclic beta-lactams and benzoxazinones“. Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354234.
Sykes, Nicholas Oliver. „Structure reactivity relationships of γ lactones, γ lactams and β sultams“. Thesis, University of Huddersfield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270545.
Brown, Tom. „Studies on the inhibition of enzymes by boronic acids and lactams“. Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670022.
Evans, P. Andrew. „New synthetic methodology for the preparation of monocyclic medium ring lactams“. Thesis, University of Cambridge, 1991. https://www.repository.cam.ac.uk/handle/1810/273132.
Hites, Maya. „Beta-lactams in obese patients: what is the adequate dosage regimen?“ Doctoral thesis, Universite Libre de Bruxelles, 2017. https://dipot.ulb.ac.be/dspace/bitstream/2013/243232/3/Table.pdf.
Doctorat en Sciences médicales (Médecine)
info:eu-repo/semantics/nonPublished
Jandaghi, Morteza. „Alkylaluminophosphonate Catalysts for Ring-Opening Polymerization of Lactones, Lactams, and Lactides“. University of Toledo / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1588957446076538.
Prando, Alessandra 1980. „Estudos sintéticos para a preparação de derivados lactâmicos = uso do ácido quínico“. [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248440.
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
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Resumo: As lactamas, de um modo geral, são de bastante interesse como alvos sintéticos, pois podem apresentar ampla variedade de funções em substratos biológicos. Este trabalho teve como objetivo a preparação de heterociclos nitrogenados, no caso lactamas, a partir do ácido quínico 1. Estas seriam inéditas e, além disso, não existem descrições na literatura de preparação de lactamas a partir do ácido quínico. A rota proposta sugere a introdução do nitrogênio via uma aminólise assistida por microondas, após manipulações químicas no grupo carboxílico inicial. A hidroxiamida formada, aqui representada como 3, foi utilizada para reações visando a formação das lactamas 4 e 7, que seriam provenientes de uma ciclização intramolecular utilizando o nitrogênio da amida como nucleófilo em reação de SN2. Com a introdução da função nitrogenada, duas seqüências sintéticas foram exploradas visando a reação de ciclização intramolecular: uma utilizando o C3 do ácido quínico como centro eletrofílico, que levaria a 4, e a outra utilizando o C5, que levaria a 7. Para uma ciclização em C3, vários testes foram realizados, mas para se chegar a um bom grupo abandonador nesta posição os resultados não foram satisfatórios. Para uma ciclização em C5 foi necessário primeiramente a inversão da estereoquímica neste centro e os melhores resultados foram obtidos via uma seqüência oxidação-redução. Após introdução de um grupo abandonador nesta posição, tratamento em meio básico levou à formação da lactama almejada. A seqüência proposta pode abrir novas alternativas para a preparação de outras lactamas e também de derivados das 4-hidroxiprolinas inéditos.
Abstract: The lactams are very interesting as synthetic targets, especially because they can show a wide variety of functions on biological substrates. This work aimed the preparation of nitrogen heterocycles, in this case lactams, from quinic acid. Their structures are unprecedented, and to the best of our knowledge, there are no reports of the preparation of lactamas from quinic acid in the literature The proposed plan suggests the introduction of the nitrogen via an aminolyses reaction assisted by microwaves of an advanced intermediate. The hydroxyamide formed, here represented as 3, was used for reactions aiming the formation of the lactams skeletons 4 and 7, which would be obtained from an intramolecular using the nitrogen of the amide group as a nucleophile on a SN2 reaction. After the introduction of nitrogenated function, two synthetic sequences were explored aiming the intramolecular cyclisation reaction: one using the C3 of quinic acid as an electrophilic center, which would lead to 4, and other using the C5, which would lead to 7. In order to make the cyclisation reaction on C3, several tests were performed but the results were not satisfactory. On the other hand, for the cyclisation on C5, it was necessary, first of all, the stereochemical inversion in this center, and best results were achieved by an oxidation-reduction sequence. After the introduction of a leaving group in this position, treatment using base led the formation of desired lactam. The proposed sequence should open new alternatives for the preparation of other lactams and also new derivatives of 4-hidroxiprolines.
Mestrado
Quimica Organica
Mestre em Química