Zeitschriftenartikel zum Thema „Johan Lundborg“

On October 1, 1936 the Stockholm economists hosted a very distinguished guest, John Maynard Keynes. Homeward bound from a visit to the Soviet Union, Keynes appeared at the Political Economy Club. The minutes, as recorded by Ingvar Svennilson, relate:1.At the invitation of the club, Mr. J.M. Keynes lectured at the Institute of Social Science on the subject “My grounds for departure from orthodox economic traditions.” The lecture was arranged with support from J.H. Palme's fund for economic education and economic research. Some 100 persons attended the lecture.2.Following the lecture, the club arranged a dinner at the student union building. In addition to Mr. and Mrs. Keynes, the dinner was attended by: the chairman Professor Ohlin, Miss Kock, Messrs. Björ, Böök, Cederwall, Dahlgren, Hammarskjöld, Helger, Johansson, Lagercrantz (guest), Lundberg, Myrdal, Rothlieb, Rooth, Suoviranta (Finland, guest) and Wigforss, as well as the undersigned. After dinner there was a discussion that continued until midnight.

Background:Idiopathic inflammatory myopathies (IIM) are rare chronic inflammatory diseases associated with high mortality and morbidity [1]. One sub-group of IIM, anti-synthetase syndrome (ASS), is characterized by the presence of autoantibodies that target aminoacyl transfer(t) RNA synthetases (aaRS), together with specific clinical manifestations such as myositis, interstitial lung disease (ILD), arthritis, mechanic’s hand, Raynaud’s syndrome and fever [2]. The most common anti-aaRS autoantibody, anti-Jo1 targeting histidyl tRNA synthetase (HisRS), is present in up to 20-30% of patients with IIM, and up to 90% of patients with myositis and ILD [3, 4]. Besides Jo1, there are today seven other identified autoantigens within the aaRS family.Objectives:A large part of patients with IIM, including individuals with clinical manifestations indicating ASS, test seronegative to all known myositis specific autoantibodies. However, these patients could potentially harbor autoantibodies against targets not tested for in clinic. In this study, we aimed at extending the detection of autoantibodies by including all cytoplasmic aaRS in the analysis of patients with IIM. We hypothesized the existence of new potential autoantigens within this protein family.Methods:The presence of anti-aaRS autoantibodies was determined using a multiplex suspension bead array assay on 242 IIM patients from the Karolinska University Hospital myositis cohort. A panel of 186 recombinant constructs, representing 57 proteins that included full-length or partial sequence overlaps between constructs of all cytoplasmic aaRS as well as other myositis related proteins, were coupled to magnetic color-coded beads and each plasma sample was tested against the complete antigen panel.Results:By the use of this multiplex method we identified patients with autoantibodies against many of the tested aaRS. Autoantibodies binding to HisRS have previously been shown to bind with higher reactivity to the WHEP domain of HisRS and this was also confirmed in this study. We confirmed reactivity against three of the other aaRS tested for in the clinic (PL-12, PL-7, and EJ). In addition, we identified patients positive for anti-Zo, -KS and -HA, autoantibodies usually not screened for in routine. Finally, our data indicates that there are autoantibodies binding to other aaRS than the previously known eight autoantigens, which will be presented.Conclusion:In this study, we could detect autoantibodies in plasma from patients with IIM, both against the most common aaRS autoantigens, but also against other aaRS that are usually not tested for in clinic. We conclude that it is important to continue the studies of anti-aaRS autoantibodies, and their correlation to clinical manifestations, and in the long run also include more aaRS autoantigens in clinical practice.References:[1]Dobloug, G.C., et al., Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study. Ann Rheum Dis, 2018. 77(1): p. 40-47.[2]Barsotti, S. and I.E. Lundberg, Myositis an evolving spectrum of disease. Immunol Med, 2018. 41(2): p. 46-54.[3]Vencovsky, J., H. Alexanderson, and I.E. Lundberg, Idiopathic Inflammatory Myopathies. Rheum Dis Clin North Am, 2019. 45(4): p. 569-581.[4]Richards, T.J., et al., Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Arthritis Rheum, 2009. 60(7): p. 2183-92.Disclosure of Interests:Charlotta Preger: None declared, Antonella Notarnicola: None declared, Cecilia Hellström: None declared, Edvard Wigren: None declared, Catia Cerqueira: None declared, Peter Nilsson: None declared, Ingrid E. Lundberg Grant/research support from: Bristol Meyer Squibb, Corbus Pharmaceuticals, Inc and Astra Zeneca, Helena Persson: None declared, Susanne Gräslund: None declared, Per-Johan Jakobsson Shareholder of: Gesynta Pharma, Grant/research support from: Gesynta Pharma, AstraZeneca,

Background:Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. anti-carbamylated (Carb), anti-acetylated (KAc), and anti-malondialdehyde acetaldehyde (MAA) modified protein antibodies, have been described. By using RA patient single-cell derived monoclonal antibodies we have previously shown that individual ACPA clones recognize small distinct citrulline-containing epitopes giving them extensive multireactivity when these epitopes are found in many peptides and proteins. Moreover, certain CCP2+ multireactive ACPA clones bind also to cabamylated and acetylated autoantigens [1].Objectives:To provide a comprehensive evaluation of serum IgG and IgA autoreactivity to different post-translational modifications in RA.Methods:We analyzed 30 different IgG and IgA AMPA reactivities to modified antigens by ELISA and autoantigen arrays, in N=1985 newly diagnosed RA patients and population controls. The study utilized both previously established (i.e IgG and IgA CCP2; IgG ACPA fine-specificities; IgG anti-Carb fibrinogen and Carb FCS; IgG and IgA Cit/Carb/KAc/Orn(Ac)-vimentin), and novel assays (e.g. IgG anti-MAA and IgG anti-acetylated histones). Association with patient characteristics such as smoking and disease activity were explored. The newly developed assays were also evaluated in SLE disease controls and CCP2+ RA-risk individuals without arthritis.Results:Carb and KAc reactivities by different assays were primarily seen in patients also positive for citrulline-reactivity. Modified vimentin (mod-Vim) peptides were used for direct comparison of different AMPA reactivities, revealing that IgA AMPA recognizing mod-Vim was mainly detected in subsets of patients with high IgG anti-Cit-Vim levels and a history of smoking. IgG acetylation reactivity was mainly detected in a subset of patients with Cit and Carb reactivity. Anti-acetylated histone 2B reactivity was RA-specific and associated with high anti-CCP2 IgG levels, multiple ACPA fine-specificities, and smoking. This reactivity was also found to be present in CCP2+ RA-risk individuals without arthritis. Our data further demonstrate that IgG autoreactivity to MAA was increased in RA compared to controls with highest levels in CCP2+ RA, but was not RA-specific, and showed low correlation with other AMPA. Anti-MAA was instead associated with disease activity and was not significantly increased in CCP2+ individuals at risk of RA. Notably, RA patients could be subdivided into four different subsets based on their AMPA IgG and IgA reactivity profiles.Conclusion:We conclude that autoantibodies exhibiting different patterns of ACPA fine-specificities as well as Carb and KAc reactivity are present in RA and may be derived from multireactive B-cell clones. Anti-Carb and anti-KAc could be considered reactivities within the “Cit-umbrella” similar to ACPA fine-specificities, while MAA is distinctly different.References:[1]Sahlström P, Hansson M, Steen J, Amara K, Titcombe PJ, Forsström B, Stålesen R, Israelsson L, Piccoli L, Lundberg K, Klareskog L, Mueller DL, Catrina AI, Skriner K, Malmström V, Grönwall C. Different Hierarchies of Anti-Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis. Arthritis Rheumatol. 2020 Oct;72(10):1643-1657. PMID: 32501655Caroline Grönwall: None declared, Lisa Liljefors: None declared, Holger Bang Employee of: Employee at ORGENTEC Diagnostika GmbH, Aase Hensvold: None declared, Monika Hansson: None declared, Linda Mathsson-Alm Employee of: Employee at Thermo Fisher Scientific, Lena Israelsson: None declared, Anna Svärd: None declared, Cyril CLAVEL: None declared, Elisabet Svenungsson: None declared, Iva Gunnarsson: None declared, Guy Serre: None declared, Saedis Saevarsdottir: None declared, Alf Kastbom: None declared, Lars Alfredsson: None declared, Vivianne Malmström: None declared, Johan Rönnelid: None declared, Anca Catrina: None declared, Karin Lundberg: None declared, Lars Klareskog: None declared

In the fall of 1997 George D. Lundberg and John E. Wennberg wrote an editorial in JAMA calling for comprehensive quality improvement programs to become the driver of the American health care system. The suggestion came during the Second European Forum on Quality Improvement in Health Care held in Paris, France, in April 1997 and was based on comments made by Donald Berwick. The concept was to focus on an organized response to problem identification and proposed solutions to improve patient care and protect the health of the public. Critical care medicine represents a large segment of health care and is undergoing dramatic changes during our managed care revolution. General ICU severity of illness models have been developed, tested, and shown to provide a useful estimate of hospital mortality for populations of critically ill patients. These systems have captured the imagination of clinical researchers and have become an integral component of a large number of publications as well as a part of many ICU databases. These risk adjustment severity models are remarkably robust for heterogeneous patient populations but the models have not been shown to validate well in new settings. We feel that by focusing on the episode of critical illness rather than each individual ICU admission and by going beyond the traditional acute hospital discharge to determine whether the patient lives or dies, we can better evaluate critical care system performance and cost-effectiveness. The incentives for high quality/low cost should favor integrated comprehensive critical care delivery systems. Programs that score well should be identified as high quality and be honored as medallion level 1 ICUs. We challenge national and international critical care societies to evaluate and then debate the described definitions and recommendations as a call to action.

Background:Autoantibodies that target aminoacyl transfer(t) RNA synthetases (aaRS) represent the serological marker of the anti-synthetase syndrome (ASS), a major subgroup of the idiopathic inflammatory myopathies (IIM) (1). Among the anti-aaRS, anti-histidyl tRNA synthetase (HisRS) autoantibodies (anti-Jo1) are the most common. Up to 90% of IIM/ASS patients diagnosed with interstitial lung disease (ILD) harbor anti-Jo1 autoantibodies (2).Objectives:Reactivity and affinity of anti-Jo1 autoantibodies from serum and broncheoalveolar lavage fluid (BALF) were investigated against HisRS autoantigen. Associations with clinical data from patients IIM/ASS were addressed.Methods:Total IgGs were purified by affinity chromatography. Samples and clinical data were obtained from: i) 26 anti-Jo1+patients (19 at diagnosis, 16/19 at follow-up, 7 BALF/matching serum at baseline; ii) 29 anti-Jo1-(25 serum at diagnosis, 4 BALF/matching serum at baseline); iii) 24 age/gender matched healthy controls. Anti-Jo1 IgG and IgA response against HisRS was evaluated by ELISA and western blot. Affinity was measured by surface plasmon resonance. HisRS full-length (HisRS-FL), two HisRS domains (ABD and CD), and two HisRS splice variants (WHEP and WHEP + ABD splice variant (SV)) were tested. Correlations between autoantibody reactivity and clinical data, at baseline and over disease course, were evaluated.Results:Anti-Jo1 autoantibodies from serum and lung bound HisRS-FL, WHEP and SV with high reactivity and affinity already at diagnosis and recognized both conformational and linear HisRS epitopes (Fig. 1). Levels of autoantibodies (against HisRS-FL, -domains and -splice variants) varied among patients and overtime. Patients with ILD, arthritis and less skin involvement presented higher anti-Jo1 titers compared to those with lower anti-Jo1 titers and to the anti-Jo1 negative group (Fig. 2). Anti-WHEP reactivity in BALF strongly correlated with poor pulmonary function.Conclusion:High reactivity and affinity at time of diagnosis indicates that autoimmunity against HisRS is most likely initiated before IIM/ASS diagnosis. Reactivity to specific splice variants of HisRS may be employed as diagnostic and prognostic markers.References:[1]Marguerie C, Bunn CC, Beynon HL, Bernstein RM, Hughes JM, So AK, Walport MJ: Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes. Q J Med 1990, 77(282):1019-1038[2]Richards TJ, Eggebeen A, Gibson K, Yousem S, Fuhrman C, Gochuico BR, Fertig N, Oddis CV, Kaminski N, Rosas IO et al: Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Arthritis Rheum 2009, 60(7):2183-2192.Fig. 1.Anti-Jo1 reactivity in total IgG purified from the first available serum sampleFig. 2.Reactivity of total anti-Jo1+ IgG purified from the first available serum close to IIM/ASS diagnosis in relation to clinical dataDisclosure of Interests:Antonella Notarnicola: None declared, Charlotta Preger: None declared, Susanna Lundström: None declared, Nuria Renard: None declared, Edvard Wigren: None declared, Eveline Van Gompel: None declared, Angeles Shunashy Galindo-Feria: None declared, Helena Persson: None declared, Maryam Fathi: None declared, Johan Grunewald: None declared, Per-Johan Jakobsson Shareholder of: Gesynta Pharma, Grant/research support from: Gesynta Pharma, AstraZeneca,, Susanne Gräslund: None declared, Ingrid E. Lundberg Grant/research support from: Bristol Meyer Squibb, Corbus Pharmaceuticals, Inc and Astra Zeneca, Catia Cerqueira: None declared

Background:LDL-levels are increased by Proprotein convertase subtilisin kexin 9 (PCSK9) which targets the LDL-receptor (LDLR). We reported that PCSK9 has immune modulatory properties in addition to LDL-lowering and ameliorates dendritic cell (DC) activation by oxidized LDL (OxLDL)1, which is abundant in atherosclerotic plaques. OxLDL is also raised and associated with cardiovascular disease (CVD) in SLE.1-3Objectives:We here investigate the role of PCSK9 in SLE both in a clinical context and in experimental ex vivo studies. The objective is to investigate if PCSK9 and its inhibition could be of relevance in SLE in addition to LDL-level related propertiesMethods:PCSK9-levels were determined by ELISA among SLE patients (n=109) and age- and sex-matched population-based controls (n=91). Common carotid intima-media thickness (IMT) and plaque occurrence were determined by B-mode ultrasound. Plaques were graded by echogenicity. Human peripheral blood monocytes from SLE patients or controls were differentiated into DCs. Effects of PCSK9 and its inhibition by silencing were studied.Results:PCSK9-levels were non-significantly higher among SLE-patients as compared to controls but associated significantly with SLE disease activity, as determined by SLAM (0.020) or SLEDAI (0.0178). There was no association between PCSK9-levels and atherosclerosis as determined by IMT, prevalence of plaques or echolucent (potentially vulnerable) plaques. PCSK9 levels were significantly associated with CVD among SLE-patients but not after adjustment for age.OxLDL induced PCSK9 in DCs and DC-maturation with increased expression of CD86 and HLA-DR. The effects were significantly stronger in DC from SLE patients than from controls. Silencing of PCSK9 abolished OxLDL-induced DC-maturation.Conclusion:PCSK9 is associated with disease activity in SLE. One underlying cause could be OxLDL, promoting DC-activation which depends on PCSK9. OxLDL induces PCSK9, an effect which is higher among SLE-patients.PCSK9 could play an unexpected immunological role in SLE and inhibition of PCSK9 could potentially play a role in disease amelioration, pending on clinical studies.References:[1]Liu A and Frostegard J. PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque.J Intern Med. 2018.[2]Frostegard J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Horkko S and Witztum JL. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations.Arthritis Rheum. 2005;52:192-200.[3]Frostegard J. Immunity, atherosclerosis and cardiovascular disease.BMC Med. 2013;11:117.Disclosure of Interests:Anquan Liu: None declared, Mizanur Rahman: None declared, Ingiäld Hafström: None declared, Sofia Ajeganova: None declared, Johan Frostegård Grant/research support from: Unconditional competitive grant from Amgen, related only to PCSK9, not the topic of this abstract

RESUMENLa historia del cristianismo no se entiende sin el complejo fenómeno mariano. El culto mariano ha afianzado la construcción de identidades colectivas, pero también individuales. La figura de la Virgen María estableció un modelo de conducta desde cada contexto histórico-cultural, remarcando especialmente los ideales de maternidad y virginidad. Dentro del imaginario católico, la Europa contemporánea ha estado marcada por la formación de una cultura aparicionista que se ha generadoa partir de diversas apariciones marianas que han establecido un canon y un marco de interpretación que ha alimentado las guerras culturales entre secularismo y catolicismo.PALABRAS CLAVE: catolicismo, Virgen María, cultura aparicionista, Lourdes, guerras culturales.ABSTRACTThe history of Christianity cannot be understood without the complex Marian phenomenon. Marian devotion has reinforced the construction of collective, but also of individual identities. The figure of the Virgin Mary established a model of conduct through each historical-cultural context, emphasizing in particular the ideals of maternity and virginity. Within the Catholic imaginary, contemporary Europe has been marked by the formation of an apparitionist culture generated by various Marian apparitions that have established a canon and a framework of interpretation that has fuelled the cultural wars between secularism and Catholicism.KEY WORDS: Catholicism, Virgin Mary, apparicionist culture, Lourdes, culture wars. BIBLIOGRAFÍAAlbert Llorca, M., “Les apparitions et leur histoire”, Archives de Sciences Sociales des religions, 116 (2001), pp. 53-66.Albert, J.-P. y Rozenberg G., “Des expériences du surnaturel”, Archives de Sciences Sociales des Religions, 145 (2009), pp. 9-14.Amanat A. y Bernhardsson, M. T. (eds.), Imagining the End. Visions of Apocalypsis from the Ancient Middle East to Modern America, London and New York, I. B. Tauris, 2002.Angelier, F. y Langlois, C. (eds.), La Salette. Apocalypse, pèlerinage et littérature (1846-1996), Actes du colloque de l’institut catholique de Paris (29- 30 de novembre de 1996), Grenoble, Jérôme Million, 2000.Apolito, P., Apparitions of the Madonna at Oliveto Citra. Local Visions and Cosmic Drama, University Park, Penn State University Press, 1998.Apolito, P., Internet y la Virgen. Sobre el visionarismo religioso en la Red, Barcelona, Laertes, 2007.Astell, A. W., “Artful Dogma: The Immaculate Conception and Franz Werfer´s Song of Bernadette”, Christianity and Literature, 62/I (2012), pp. 5-28.Barnay, S., El cielo en la tierra. Las apariciones de la Virgen en la Edad Media, Madrid, Encuentro, 1999.Barreto, J., “Rússia e Fátima”, en C. Moreira Azevedo e L Cristino (dirs.), Enciclopédia de Fátima, Estoril, Princípia, 2007, pp. 500-503.Barreto, J., Religião e Sociedade: dois ensaios, Lisboa, Instituto de Ciências Sociais da Universidade de Lisboa, 2003.Bayly, C. A., El nacimiento del mundo moderno. 1780-1914, Madrid, Siglo XXI, 2010.Béjar, S., Los milagros de Jesús, Barcelona, Herder, 2018.Belli, M., An Incurable Past. Nasser’s Egypt. Then and Now, Gainesville, University Press of Florida, 2013.Blackbourn, D., “Apparitions of the Virgin Mary in Bismarckian Germany”, en Eley, G. (ed.), Society, Culture, and the State in Germany, 1870-1930, Ann Arbor, The University Michigan Press, 1997.Blackbourn, D., Marpingen: Apparitions of the Virgin Mary in Nineteenth-Century Germany, New York, Alfred A. Knopf, 1994.Bouflet, J., Une histoire des miracles. Du Moyen Âge à nos jours, Paris, Seuil, 2008.Boyd, C. P., “Covadonga y el regionalismo asturiano”, Ayer, 64 (2006), pp. 149-178.Brading, D. A., La Nueva España. Patria y religión, México D. F., Fondo de Cultura Económica, 2015.Brading, D. A., Mexican Phoenix, our Lady of Guadalupe: image and tradition across five centuries, Cambridge, Cambridge University Press, 2001.Bugslag, J., “Material and Theological Identities: A Historical Discourse of Constructions of the Virgin Mary”, Théologiques, 17/2 (2009), pp. 19-67.Cadoret-Abeles, A., “Les apparitions du Palmar de Troya: analyse anthropologique dun phenómène religieux”, Mélanges de la Casa de Velázquez, 17 (1981), pp. 369-391.Carrión, G., El lado oscuro de María, Alicante, Agua Clara, 1992.Chenaux, P., L´ultima eresia. La chiesa cattolica e il comunismo in Europa da Lenin a Giovanni Paolo II, Roma, Carocci Editore, 2011.Christian, W. A., “De los santos a María: panorama de las devociones a santuarios españoles desde el principio de la Edad Media a nuestros días”, en Lisón Tolosana, C. (ed.), Temas de antropología española, Madrid, Akal, 1976, pp. 49-105.Christian, W. A., “Religious apparitions and the Cold War in Southern Europe”, Zainak, 18 (1999), pp. 65-86.Christian, W. A., Apariciones Castilla y Cataluña (siglo XIV-XVI), Madrid, Nerea, 1990.Christian, W. A., Religiosidad local en la España de Felipe II, Madrid, Nerea, 1991.Christian, W. A., Religiosidad popular: estudio antropológico en un valle, Madrid, Tecnos, 1978.Christian, W. A., Visionaries: The Spanish Republic and the Reign of Christ, Berkeley, University of California Press, 1997.Clark, C., “The New Catholicism and the European Culture Wars”, en C. Clark y Kaiser, W. (eds.), Culture Wars. Secular-Catholic conflict in Nineteenth-Century Europe, Cambridge, Cambridge University Press, 2003, pp. 11-46.Claverie, É., Les guerres de la Vierge. Une anthropologie des apparitions, Paris, Gallimard, 2003.Colina, J. M. de la, La Inmaculada y la Serpiente a través de la Historia, Bilbao, El Mensajero del Corazón de Jesús, 1930.Collins, R., Los guardianes de las llaves del cielo, Barcelona, Ariel, 2009, p. 521.Corbin, A. (dir.), Historia del cuerpo. Vol. II. De la Revolución francesa a la Gran Guerra, Madrid, Taurus, 2005.Coreth, E. (ed.), Filosofía cristiana en el pensamiento católico de los siglos XIX y XX. Tomo I: Nuevos enfoques en el siglo XIX, Madrid, Encuentro, 1994.Coreth, E. (ed.), Filosofía cristiana en el pensamiento católico de los siglos XIX y XX. Tomo II: Vuelta a la herencia escolástica, Madrid, Encuentro, 1994.Cunha, P. y Ribas, D., “Our Lady of Fátima and Marian Myth in Portuguese Cinema”, en Hansen, R. (ed.), Roman Catholicism in Fantastic Film: Essays on. Belief, Spectacle, Ritual and Imagery, Jefferson, McFarland, 2011.D’Hollander, P. y Langlois, C. (eds.), Foules catholiques et régulation romaine. Les couronnements de vierges de pèlerinage à l’époque contemporaine (XIXe et XXe siècles), Limoges, Presses universitaires de Limoges, 2011.D´Orsi, A., 1917, o ano que mudou o mundo, Lisboa, Bertrand Editora, 2017.De Fiores, S., Maria. Nuovissimo dizionario, Bologna, EDB, 2 vols., 2006.Delumeau, J., Rassurer et protéger. Le sentiment de sécurité dans l’Occident d’autrefois, Paris, Fayard, 1989.Dozal Varela, J. C., “Nueva Jerusalén: a 38 años de una aparición mariana apocalíptica”, Nuevo Mundo, Mundos Nuevos, 2012, s.p.Driessen, H., “Local Religion Revisited: Mediterranean Cases”, History and Anthropology, 20/3 (2009), pp. 281-288.Driessen, H., “Local Religion Revisited: Mediterranean Cases”, History and Anthropology, 20/3 (2009), p. 281-288.González Sánchez, C. A., Homo viator, homo scribens. Cultura gráfica, información y gobierno en la expansión atlántica (siglos XV-XVII), Madrid, Marcial Pons, 2007.Grignion de Montfort, L. M., Escritos marianos selectos, Madrid, San Pablo, 2014.Harris, R., Lourdes. Body and Spirit in the Secular Age, London, Penguin Press, 1999.Harvey, J., Photography and Spirit, London, Reaktion Books, 2007.Hood, B., Supersense: Why We Believe in the Unbelievable, New York, HarperOne, 2009.Horaist, B., La dévotion au Pape et les catholiques français sous le Pontificat de Pie IX (1846-1878), Palais Farnèse, École Française de Rome, 1995.Kselman, T., Miracles and Prophecies in Nineteenth Century France, New Brunswick, Rutgers University Press, 1983.Lachapelle, S., Investigating the Supernatural: From Spiritism and Occultism to Psychical Research and Metapsychics in France, 1853-1931, Baltimore, The John Hopkins University Press, 2011.Langlois, C., “Mariophanies et mariologies au XIXe siècles. Méthode et histoire”, en Comby, J. (dir.), Théologie, histoire et piété mariale, Lyon, Profac, 1997, pp. 19-36.Laurentin, R. y Sbalchiero, P. (dirs.), Dictionnaire des “aparitions” de la Vierge Marie, Paris, Fayard, 2007.Laycock, J. P., The Seer of Bayside: Veronica Lueken and the Struggle to Define Catholicism, Oxford, Oxford University Press, 2015.Levi, G., La herencia inmaterial. La historia de un exorcista piamontés del siglo XVII, Madrid, Nerea, 1990.Linse, U., Videntes y milagreros. La búsqueda de la salvación en la era de la industrialización, Madrid, Siglo XXI, 2002.Louzao, J., “La España Mariana: vírgenes y nación en el caso español hasta 1939”, en Gabriel, P., Pomés, J. y Fernández, F. (eds.), España res publica: nacionalización española e identidades en conflicto (siglos XIX y XX), Granada, Comares, 2013, pp. 57-66.Louzao, J., “La recomposición religiosa en la modernidad: un marco conceptual para comprender el enfrentamiento entre laicidad y confesionalidad en la España contemporánea”, Hispania Sacra, 121 (2008), pp. 331-354.Louzao, J., “La Señora de Fátima. La experiencia de lo sobrenatural en el cine religioso durante el franquismo”, en Moral Roncal, A. M. y Colmenero, R. (eds.), Iglesia y primer franquismo a través del cine (1939-1959), Alcalá de Henares, Universidad de Alcalá de Henares, 2015, pp. 121-151.Louzao, J., “La Virgen y la salvación de España: un ensayo de historia cultural durante la Segunda República”, Ayer, 82 (2011), pp. 187-210.Louzao, J., Soldados de la fe o amantes del progreso. Catolicismo y modernidad en Vizcaya (1890-1923), Logroño, Genueve Ediciones, 2011.Lowenthal, D., El pasado es un país extraño, Madrid, Akal, 1998.Lundberg, M., A Pope of their Own. El Palmar de Troya and the Palmarian Church, Uppsala, Uppsala University, 2017.Maravall, J. A., La cultura del Barroco, Madrid, Ariel, 1975.Martí, J., “Fundamentos conceptuales introductorios para el estudio de la religión”, en Ardèvol, E. y Munilla, G. (coords.), Antropología de la religión. Una aproximación interdisciplinar a las religiones antiguas y contemporáneas, Barcelona, Editorial Universitat Oberta Catalunya, 2003.Martina, G., Pio IX (1846-1850), Roma, Università Gregoriana, 1974.Martina, G., Pio IX (1851-1866), Roma, Università Gregoriana,1986.Martina, G., Pio IX (1867-1878), Roma, Università Gregoriana, 1990.Maunder, C., “The Footprints of Religious Enthusiasm: Great Memorials and Faint Vestiges of Belgium´s Marian Apparition Mania of the 1930s”, Journal of Religion and Society, 15 (2013), s.p.Maunder, C., Our Lady of the Nations: Apparitions of Mary in Twentieth-century Catholic, Oxford, Oxford University Press, 2016.Mínguez, R., “Las múltiples caras de la Inmaculada: religión, género y nación en su proclamación dogmática (1854)”, Ayer, 96 (2014), pp. 39-60.Moreno Luzón, J., “Entre el progreso y la virgen del Pilar. La pugna por la memoria en el centenario de la Guerra de la Independencia”, Historia y política, 12 (2004), pp. 41-78.Moro, R., “Religion and Politics in the Time of Secularisation: The Sacralisation of Politics and the Politicisation of Religion”, Totalitarian Movements and Political Religions, 6/1 (2005), pp. 71-86.Multon, H., “Catholicisme intransigeant et culture prophétique: l’apport des Archives du Saint Office et de l’Index”, Revue historique, 621 (2002), pp. 109-137.Osterhammel, J., The Transformation of the World: A Global History of the Nineteenth Century, Princeton, Princeton University Press, 2014.Oviedo Torró, L., “Natural y sobrenatural: un repaso a los debates recientes”, en Alonso Bedate, A. (ed.), Lo natural, lo artificial y la cultura, Madrid, Universidad Pontificia Comillas, pp. 151-166.Pelikan, J., María a través de los siglos. Su presencia en veinte siglos de cultura, Madrid, PPC, 1997.Perica, V., Balkan Idols: Religion and Nationalism in Yugoslav States, Oxford, Oxford University Press, 2002.Rahner, K., Tolerancia, libertad, manipulación, Barcelona, Herder, 1978.Ramón Solans, F. J. y di Stefano, R. (eds.), Marian Devotions, Political Mobilization, and Nationalism in Europe and America, Basingstoke, Palgrave, 2016.Ramón Solans, F. J., “A New Lourdes in Spain: The Virgin of El Pilar, Mass Devotion, National Symbolism and Political Mobilization”, en Ramón Solans, F. J. y di Stefano, R. (eds.), Marian Devotions, Political Mobilization, and Nationalism in Europe and America, Basingstoke, Palgrave, 2016, pp. 137-167.Ramón Solans, F. J., “La hidra revolucionaria. Apocalipsis y antiliberalismo en la España del primer tercio del siglo XIX”, Hispania, 56 (2017), pp. 471-496.Ramón Solans, F. J., La Virgen del Pilar dice... Usos políticos y nacionales de un culto mariano en la España contemporánea, Zaragoza, Prensas Universitarias de Zaragoza, 2014.Ridruejo, E., Apariciones de la Virgen María: una investigación sobre las principales Mariofanías en el mundo Zaragoza, Fundación María Mensajera, 2000.Ridruejo, E., Memorias de Pitita, Madrid, Temas de Hoy, 2002.Rodríguez Becerra, S., “Las leyendas de apariciones marianas y el imaginario colectivo”, Etnicex: Revista de Estudios Etnográficos, 6 (2014), pp. 101-121.Rousseau, J. J., Ouvres Completes. Tome VII, Frankfort, H. Bechhold, 1856.Rubial García, A., Profetisas y solitarios: espacios y mensajes de una religión dirigida por ermitaños y beatas laicos en las ciudades de Nueva España, México D. F., Fondo de Cultura Económica, 2006.Rubin, M., Mother of God. A History of the Virgin Mary, London, Penguin, 2010.Russell, J. B., The Prince of Darkness: Radical Evil and the Power of Good in History, Cornell, Cornell University Press, 1992.Sánchez-Ventura, F., El pensamiento de María mensajera, Zaragoza, Fundación María Mensajera, 1997.Sánchez-Ventura, F., María, precursora de Cristo en su segunda venida a la tierra. Estudio de las profecías en relación con el próximo retorno de Jesús, Zaragoza, Círculo, 1973.Skinner, Q., Visions of Politics. Volumen 1: Regarding Method, Cambridge, Cambridge University Press, 2002.Staehlin, C. M., Apariciones. Ensayo crítico, Madrid, Razón y Fe, 1954.Stark R. y Finke, R., Acts of Faith: Explaining Human Side of Religion, Berkeley, University of California Press, 2000.Thomas, K., Religion and the Decline of Magic, New York, Scribner’s, 1971.Torbado, J., Milagro, milagro, Barcelona, Plaza y Janés, 2000.Turner, V. y Turner, E., Image and Pilgrimage in Christian Culture. Anthropological perspectives, New York, Columbia University Press, 1978.Vélez, P. V., Realidades, Barcelona, Imprenta Moderna, 1906.Walker, B., Out of the Ordinary Folklore and the Supernatural, Utah, Utah State University Press, 1995.Walliss, J., “Making Sense of the Movement for the Restoration of the Ten Commandments of God”, Nova Religio: The Journal of Alternative and Emergent Religions, 9/1 (2005), pp. 49-66.Warner, M., Tú sola entre las mujeres: el mito y el culto de la Virgen María, Madrid, Taurus, 1991.Watkins, C. S., History and the Supernatural in Medieval England, Cambridge, Cambridge University Press, 2007.Weber, M., Ensayos sobre sociología religiosa, Madrid, Taurus, 1983.Weigel, G., Juan Pablo II. El final y el principio, Barcelona, Planeta, 2011.Werfel, F., La canción de Bernardette, Madrid, Palabra, 1988.Zimdars-Swartz, S. L., Encountering Mary: From La Salette to Medjugorje, Princenton, Princeton University Press, 2014.

Abstract Health inequalities - systematically higher rates of morbidity and mortality among people with a lower socioeconomic position - have been on the public health agenda for decades now. However, despite massive research efforts (and somewhat less massive policy efforts) health inequalities have not narrowed - on the contrary, relative inequalities have widened considerably. It is therefore time for a re-think: after decades of research we need to step back and ask ourselves: what went wrong? Johan Mackenbach argues, in a book published by Oxford University Press (2019), that the main problem is that public health researchers and policy-makers have misunderstood the nature of health inequalities. They have too often ignored insights from other disciplines, such as economics (which has a stricter attitude to issues of causality) and sociology (which has a subtler understanding the nature of social inequality). They have also failed to integrate contradictory research findings into mainstream thinking. This workshop will focus on three such contradictions, and will discuss whether it is possible to re-think health inequalities in a way that will allow more effective policy approaches. (1) It has been surprisingly difficult to find convincing scientific evidence for a causal effect of socioeconomic disadvantage on health. Should public health reconsider its idea that health inequalities are caused by social inequalities, and widen their scope to give more room to social selection, genetic factors and other non-causal pathways in their analysis? (2) There is not a single country in Europe where over the past decades health inequalities, as measured on a relative scale, have narrowed. This is due to the fact that all groups have improved their health, but higher socioeconomic groups have improved more. This is even true in the only European country (i.e., England) in which the government has pursued a large-scale policy program to reduce health inequalities. Should public health accept that reducing relative inequalities in health is impossible, and focus on reducing absolute health inequalities instead? (3) The Nordic countries, which have been more successful than other European countries in reducing inequalities in material living conditions, do not have smaller health inequalities. It is as if inequalities in other factors, such as psychosocial and behavioural factors, in these countries have filled the gap left by reduced inequalities in material living conditions. Should public health reconsider its idea that material living conditions are the foundation for health, and re-focus on psychological, cultural and other less tangible factors instead? In this round table Johan Mackenbach will present and illustrate these contradictions and propose his answers to these contentious issues. Then, the four panelists will present their view-points, followed by a general discussion between panelists and the audience. Key messages After four decades of research into health inequalities, it is necessary to step back and ask ourselves why it has so far been impossible to reduce health inequalities. More effective policies to tackle health inequalities will only be possible when public health has come to grips with contradictory research findings. Johan Mackenbach Contact: j.mackenbach@erasmusmc.nl Johannes Siegrist Contact: johannes.siegrist@med.uni-duesseldorf.de Alastair Leyland Contact: Alastair.Leyland@glasgow.ac.uk Olle Lundberg Contact: olle.lundberg@su.se Ramune Kalediene Contact: ramune.kalediene@lsmuni.lt

ABSTRACT The history of knowledge about Amazonian biogeography is as rich as its fish community, and a fascinating theme of study in itself. Several current paradigms and controversies about Amazonian fish biogeography are rooted in principles dating from the second half of the 18th to the first half of the 19th centuries. The present work establishes a relationship between current biogeographical ideas and their old predecessors, on the basis of a chronologically-oriented historical continuity analysis. The advent of evolutionary theory has not contributed significantly to a transformation of the knowledge on the biogeography of Amazonian fishes. On the other hand, the two main schools of biogeographical thought (dispersalist and vicariant) had major implications on how Amazonian fish distribution is interpreted. The process was gradual and many hypotheses have combined elements from each of the two schools. Chronologically, practically the entire tradition of Amazonian biogeography takes place within the evolutionary paradigm, although its founder Louis Agassiz was himself an anti-evolutionist. The birth of Amazonian biogeography is Agassiz´s travel in Amazon. That document makes it clear that the author did not consider dispersal as a valid explanation for the biogeographical patterns he found. Later, Carl Eigenmann helps to spread the dispersalist tradition as a model for biogeographical explanations in fish distributions, a phase which lasted until the late 20th century. A major shift occurs with the contributions of Marylin Weitzman, Stanley Weitzman and Richard Vari, who associated the temporal framework of phylogenetic hypotheses with distribution patterns, underscoring the predictive power of vicariant biogeography. The present-day paradigm begins with the work of John Lundberg and attempts to incorporate geomorphological and phylogenetic information into integrative biogeographical hypotheses. Some emblematic problems have delayed proposition of general hypotheses on the phylogenetic biogeography of South American fishes, such as the poor state of knowledge of their species-level systematics; an incomplete distributional record for most species and sparse or non-existent data on the phylogenetic history of most supraspecific taxa. Such drawbacks are now being corrected at a fast pace. Recent advances on geographical distribution and an increasing number of phylogenetic hypotheses will allow unprecedented large-scale biogeographic analyses, including those based on event models and Bayesian inference. Thus, the biogeography of South American fishes, especially Amazonian ones, should soon experiment a new age of progress. The success of that new phase will depend on its ability to recognize and segregate multiple overlapping temporal layers of hydrological changes, and to develop analytical tools that can deal with temporal mixing.