Thematische Bibliographien / IVDR

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Auswahl der wissenschaftlichen Literatur zum Thema „IVDR“

Autor: Grafiati

Veröffentlicht am 30. Juni 2021

Zuletzt aktualisiert am 1. Februar 2022

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Zeitschriftenartikel zum Thema "IVDR"

Nayak, Shashank, M. P. Venkatesh und Pramod Kumar T.M. „EU IVDR Regulatory Changes: An Overview of Requirements in (EU) 2017/746“. Applied Clinical Research, Clinical Trials and Regulatory Affairs 7, Nr. 3 (24.12.2020): 237–43. http://dx.doi.org/10.2174/2213476x07666200327143023.

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IVDR is the new regulatory basis for placing IVDs in the market, making them available and putting them into service in the European market. EU IVDR regulation is much bigger than the impact of EU IVDD, which is a bold statement to make, considering the significant industry- wide impact as it presents challenges to the manufacturer. Rather, it is largely a revision that contains guidance on how to fulfill the existing IVDD requirements. IVDR focused on the IVD-specific provisions therein regarding classification, performance evaluations, clinical data, conformity assessments and notified bodies. IVDR presents enormous change to the IVD industry, not only because it needs a significant change in technical documentation and Quality management system, but also because it changes the relationship with the economic operator and their responsibilities.

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Du, Zhenya, Fusheng Chen, Kunlun Liu, Shaojuan Lai, Lifen Zhang, Guanhao Bu, Xueli Gao und Shaobo Liu. „Effects of Extruded Soy Protein on the Quality of Chinese Steamed Bread“. Journal of Chemistry 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3691523.

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Five different extruded soy protein isolates (ESPIs) were obtained by extrusion and denoted by IVD1, IVD2, IVD3, IVD4, and IVD5. Then the SDS-PAGE results showed that the subunits of SPI decreased after extrusion, especially the subunits of 90.8, 32.8, and 31.3 kDa, whereas no isopeptide bond was formed. Although SPI improved both the development time (DT) and stability (S) of dough, ESPIs increasedSbut the DT decreased from 4.3 min to 1.8–2.0 min. Texture profile analysis (TPA) results showed that the hardness and chewiness of Chinese steamed bread (CSB) decreased in the order wheat flour+IVD2 (WF+IVD2), WF+SPI, WF+IVD4, WF+IVD1, WF+IVD3, WF, and WF+IVD5. As regards color, the total colorΔEdecreased except for the WF+IVD1 (56.22); its positive and negative trends ofL⁎andb⁎were invariant with the SPI or ESPIs mixture, whereasa⁎showed a positive trend. The sensory score increased from 82.7 to 83.4 with 3% of SPI addition and up to 87.8 when the substitution was IVD1. Therefore, SPI treated by extrusion may significantly improve the quality of CSB.

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Naga Gouri T, Venkatesh M P, Balamuralidhara V und Pramod Kumar T M. „A futuristic study on in-vitro medical devices regulations“. International Journal of Research in Pharmaceutical Sciences 11, Nr. 2 (28.04.2020): 2221–27. http://dx.doi.org/10.26452/ijrps.v11i2.2173.

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The In-Vitro Medical Devices Directive (IVDD) established in 1998 by the European Union met the requirements of the single medical device market. In the due course, IVDD could not regulate all new technical and medical developments in the sector. The IVDD 98/79/EC, was preceded with IVDR 2017//746; which defined and demonstrated conformity to essential requirements, established harmonized standards and facilitated the organization of ‘Notified Body’ (NB), Competent Authority oversight and market surveillance. IVDR implemented streamlines as defined in Annex I of the EU IVDR 2017/746 conforming to the relationships between the performance requirements and general safety, and Annex I of the EU Directive 98/79/EC for IVDD for the essential requirements. The importance of the Unique Device Identification and its implementation in the safety and conformity of the device was made stringent for the manufacturers. The recent developments in IVDR, with reference to EUDAMED database, enable the applicant for accessing of data entered for the revival, correction and the assessing of information.

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Vermeersch, Pieter, Tobias Van Aelst und Elisabeth M. C. Dequeker. „The new IVD Regulation 2017/746: a case study at a large university hospital laboratory in Belgium demonstrates the need for clarification on the degrees of freedom laboratories have to use lab-developed tests to improve patient care“. Clinical Chemistry and Laboratory Medicine (CCLM) 59, Nr. 1 (26.01.2021): 101–6. http://dx.doi.org/10.1515/cclm-2020-0804.

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AbstractObjectivesThe new European In Vitro Diagnostic (IVD) Regulation 2017/746 (IVDR) restricts the use of lab-developed tests (LDT) after 26th May 2022. There are no data on the impact of the IVDR on laboratories in the European Union.MethodsLaboratory tests performed in UZ Leuven were divided in four groups: core laboratory, immunology, special chemistry, and molecular microbiology testing. Each test was classified as Conformité Européenne (CE)-IVD, modified/off-label CE-IVD, commercial Research Use Only (RUO) or LDT. Each matrix was considered a separate test.ResultsWe found that 97.6% of the more than 11.5 million results/year were generated with a CE-IVD method. Of the 922 different laboratory tests, however, only 41.8% were CE-IVD, 10.8% modified/off-label CE-IVD, 0.3% RUO, and 47.1% LDT. Off-label CE-IVD was mainly used to test alternative matrices not covered by the claim of the manufacturer (e.g., pleural or peritoneal fluid). LDTs were mainly used for special chemistry, flow cytometry, and molecular testing. Excluding flow cytometry, the main reasons for the use of 377 LDTs were lack of a CE-IVD method (71.9%), analytical requirements (14.3%), and the fact the LDT was in use before CE-IVD available (11.9%).ConclusionsWhile the large majority of results (97.6%) were generated with a CE-IVD method, only 41.8% of laboratory tests were CE-IVD. There is currently no alternative on the market for 71.5% of the 537 LDTs performed in our laboratory which do not fall within the scope of the current IVD directive (IVDD). Compliance with the IVDR will require a major investment of time and effort.

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Jacobs, Leo. „IVDR“. Laboratoriumgeneeskunde 3, Nr. 5 (Oktober 2020): 6. http://dx.doi.org/10.24078/labgeneeskunde.2020.10.126050.

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Kugiya, F., H. Nishida, A. Saitou und N. Kodama. „iVDR business perspective“. Journal of Magnetism and Magnetic Materials 320, Nr. 22 (November 2008): 2894–99. http://dx.doi.org/10.1016/j.jmmm.2008.07.043.

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Tawfik, O., L. Peterson, R. Parker, E. Mechetner, M. Davis, J. Chapman, Q. Khan und J. Ma. „Correlation between immunohistochemical biomarker expression and in vitro drug response factors in stage III-IV ovarian cancer“. Journal of Clinical Oncology 25, Nr. 18_suppl (20.06.2007): 16055. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.16055.

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16055 Background: The reliability of molecular biomarkers as predictors of treatment outcome remains unclear and, in relation to drug resistance even less is known. Immunohistochemical (IHC) expression of biomarkers and in vitro drug resistance (IVDR) relative to clinical outcome were evaluated in patients with stage III-IV epithelial ovarian cancer (OC) who received combination carboplatin (CAR) plus paclitaxel (TAX) chemotherapy. Methods: We correlated clinical outcome with histopathology and biomarker expression of MIB-1, p53, BCL2, EGFR, ER and PR in 98 OC patients with tumors tested for IVDR by extreme drug resistance (EDR) assay. IVDR was determined following exposures to single agents CAR, cisplatin (CP), TAX, taxotere (TXT), gemcitabine (GCB), topotecan (TP), liposomil doxorubicin, and cytoxan (CT). Percentage cell growth inhibition (PCI) for each drug was compared with PCI from untreated control cultures. Results: Tumors with prior chemotherapy (n=29) were more resistant to CAR (unpaired t-test, p=0.046), and CT (p=0.038), and more sensitive to liposomil doxorubicin (p=0.009), compared to treatment naive tumors (n=53). For 65 tumors, there was a positive relationship between MIB-1 vs p53 (r=0.419; p=0.001), and between ER vs PR (r=0.339; p=0.011). Correlation between biomarkers and drug response showed a significantly inverse relationship between MIB-1 vs liposomil doxorubicin, p53 vs liposomil doxorubicin, EGFR vs CAR, CP, GCB and TAX; and between ER vs TXT and CT, and PR vs CT and TP. With a 53% (33/61) response rate to CAR+TAX, time to progression (TTP) for responders (R) with EGFR+ tumors was longer (median TTP 15.6 mo); and shorter for R with EGFR- tumors (p=0.008). For R and non-R, BCL2+ tumors had longer overall survival (OS) (median OS 23.3 mo; p=0.006). No other significant correlations were seen. Conclusion: Prior chemotherapy increased IVDR to CAR and CT, and increased sensitivity to liposomil doxorubicin. Increased expression of proliferation biomarkers, particularly EGFR, correlated with resistance to several chemotherapeutic agents. EGFR expression in responders was associated with longer TTP. The significance of in vitro correlates of prognostic biomarker expression and IVDR for predicting chemoresistance warrants prospective studies to assess its value in clinical settings. [Table: see text]

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De Decker, Steven, Anne-Sophie Warner und Holger A. Volk. „Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats“. Journal of Feline Medicine and Surgery 19, Nr. 4 (09.07.2016): 419–23. http://dx.doi.org/10.1177/1098612x16630358.

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Objectives The objective was to evaluate the prevalence and possible breed predilections for thoracolumbar intervertebral disc disease (IVDD) in cats. Methods Medical records and imaging studies of cats diagnosed with thoracolumbar IVDD between January 2008 and August 2014 were retrospectively reviewed and compared with the general hospital population. The association between type of IVDD (ie, intervertebral disc extrusion [IVDE] or intervertebral disc protrusion [IVDP]) and breed, age, sex, and duration and severity of clinical signs was also evaluated. Results Of 12,900 cats presented during the study period, 31 (0.24%) were diagnosed with IVDD, including 17 purebred and 14 non-purebred cats. Of all presented purebred cats, 0.52% were diagnosed with thoracolumbar IVDD. More specifically, 1.29% of all British Shorthairs and 1.83% of all presented Persians were diagnosed with IVDD. Compared with the general hospital population, purebred cats ( P = 0.0001), British Shorthairs ( P <0.0001) and Persians ( P = 0.0006) were significantly overrepresented with thoracolumbar IVDD. Affected purebred cats were younger than affected non-purebred cats ( P = 0.02). Of 31 cats with IVDD, 19 were diagnosed with IVDE and 12 with IVDP. Cats with IVDE had a significantly shorter duration of clinical signs ( P = 0.0002) and demonstrated more severe neurological deficits ( P = 0.04) than cats with IVDP. Conclusions and relevance Although thoracolumbar IVDD is an uncommon condition in cats, purebred cats, British Shorthairs and Persians, were overrepresented. It is currently unclear if this represents a true breed predisposition or a higher likelihood of owners of purebred cats seeking referral for advanced diagnostic imaging procedures.

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Kupka, Johannes, Annika Kohler, Karima El Bagdadi, Richard Bostelmann, Marco Brenneis, Christoph Fleege, Danny Chan et al. „Adrenoceptor Expression during Intervertebral Disc Degeneration“. International Journal of Molecular Sciences 21, Nr. 6 (18.03.2020): 2085. http://dx.doi.org/10.3390/ijms21062085.

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Healthy and degenerating intervertebral discs (IVDs) are innervated by sympathetic nerves, however, adrenoceptor (AR) expression and functionality have never been investigated systematically. Therefore, AR gene expression was analyzed in both tissue and isolated cells from degenerated human IVDs. Furthermore, human IVD samples and spine sections of wildtype mice (WT) and of a mouse line that develops spontaneous IVD degeneration (IVDD, in SM/J mice) were stained for ARs and extracellular matrix (ECM) components. In IVD homogenates and cells α1a-, α1b-, α2a-, α2b-, α2c-, β1-, and β2-AR genes were expressed. In human sections, β2-AR was detectable, and its localization parallels with ECM alterations. Similarly, in IVDs of WT mice, only β2-AR was expressed, and in IVDs of SM/J mice, β2AR expression was stronger accompanied by increased collagen II, collagen XII, decorin as well as decreased cartilage oligomeric matrix protein expression. In addition, norepinephrine stimulation of isolated human IVD cells induced intracellular signaling via ERK1/2 and PKA. For the first time, the existence and functionality of ARs were demonstrated in IVD tissue samples, suggesting that the sympathicus might play a role in IVDD. Further studies will address relevant cellular mechanisms and thereby help to develop novel therapeutic options for IVDD.

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SAITOU, Atsushi, Fumio KUGIYA und Naoki KODAMA. „Standardization ^|^amp; Application Expansion Activity of Removable HDD (iVDR)“. IEICE Transactions on Electronics E96.C, Nr. 12 (2013): 1508–14. http://dx.doi.org/10.1587/transele.e96.c.1508.

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Dissertationen zum Thema "IVDR"

Bamyr, Hanssen Soziar, und Rosemarie Ohanyan. „Konsekvenserna av (EU) 2017/746- förordningen på tillverkning och användning av medicintekniska produkter för in vitro-diagnostik inom Karolinska Universitetssjukhuset“. Thesis, KTH, Medicinteknik och hälsosystem, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-297857.

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In collaboration with the Karolinska University Hospital, this research was carried out with the aim of executing a consequence analysis of the new regulation (EU) 2017/746. The consequences of the regulation regarding access, distribution, manufacturing and in-house production of in vitro diagnostic products were examined for various departments at the Karolinska University Hospital. This was investigated through an extensive literature study and interviews that were conducted digitally and through email. Of the departments examined, attention was drawn to the fact that only Lab & Primary Health Care and the Karolinska University Laboratory were affected by the new regulation. The availability of products may be affected as a consequence of the new requirements for risk classification and the notified bodies. If the manufacturer does not meet the new requirements, this may lead to a shortage of materials and products, which can affect Lab & Primary Care and the Karolinska University Laboratory. Lab & Primary Health Care will be affected by the requirements for distribution in the new regulation if they decide to distribute new in vitro diagnostic products to other businesses. The Karolinska University Laboratory has a production that they currently CE mark according to the old directive and an in-house production. In order for the Karolinska University Laboratory to continue its own production, it is required that they meet the requirements imposed on in-house production in the new regulation. With continued CE marking of the products, they will be classified as manufacturers and need to meet its requirements. In summary, it can be stated that both Lab & Primary Health Care and the Karolinska University Laboratory have three paths to go; distribute, produce in-house or manufacture in vitro diagnostic products. Depending on the decision they make, they are classified differently according to the new regulation (distributors, in-house manufacturers or manufacturers) and thus have different requirements to follow.
I samarbete med Karolinska Universitetssjukhuset utfördes denna studie med målet att genomföra en konsekvensanalys av det nya regelverket (EU) 2017/746. Regelverkets konsekvenser gällande tillgång, distribution, tillverkning och egentillverkning av in vitro-diagnostik produkter undersöktes för olika enheter inom Karolinska Universitetssjukhuset. Detta undersöktes genom en omfattande litteraturstudie och intervjuer som utfördes digitalt och via mail. Av de enheter som granskades uppmärksammades att endast Lab & Primärvård och Karolinska Universitetslaboratoriet påverkades av den nya lagstiftningen. Tillgången på produkter kan komma att påverkas som en konsekvens av de nya kraven på riskklassificering och på de anmälda organen. Om tillverkaren inte uppfyller de nya kraven kan detta leda til brist på material och produkter, vilken kan påverka Lab & Primärvård samt Karolinska Universitetslaboratoriet. Lab & Primärvård kommer beröras av kraven för distribution i den nya förordningen om de beslutar att distribuera nya in vitro-diagnostik produkter till andra verksamheter. Karolinska Universitetslaboratoriet har en tillverkning som de i dagsläget CE-märker enligt det gamla direktivet samt en egentillverkning. För att Karolinska Universitetslaboratoriet ska fortsätta sin egentillverkning krävs det att de uppfyller kraven som ställs på egentillverkare i nya regelverket. Vid fortsatt CE-märkning av produkterna kommer de att klassas som tillverkare och behöver uppfylla dess krav. Sammanfattningsvis kan det konstateras att både Lab & Primärvård och Karolinska Universitetslaboratoriet har tre vägar att gå; distribuera, egentillverka eller tillverka in vitro-diagnostik produkter. Beroende på beslutet de fattar klassas de olika enligt det nya regelverket (distributörer, egentillverkare eller tillverkare) och har därmed olika krav att följa.

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Franzén, Niclas. „Ensamhetsmotivet hos Ivar Arosenius“. Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-65997.

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Uppsatsen behandlar ensamhetsmotivet hos konstnären Ivar Arosenius. Ensamhetsbilderna delas in i olika kategorier efter motiv och stämningsläge. Bilderna analyseras sedan med fokus på symbolistiska tendenser, återkommande teman och influenser från andra konstnärer.
This paper deals with the solitude motif of the artist Ivar Arosenius. His solitude pictures are divided into different categories according to subject and sentiment. The images are then analyzed with a focus on symbolistic tendencies, recurring themes and influences from other artists.

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Kennedy, Katherine. „Ivor Gurney : poetry, song and the institution“. Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609149.

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Hillebrand, Ivor Henry. „Die werksmotivering van die onderwyseres / Ivor Henry Hillebrand“. Thesis, Potchefstroom University for Christian Higher Education, 1989. http://hdl.handle.net/10394/8957.

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1. ACTUALITY OF THIS RESEARCH: Sixty-five percent of teachers in secondary schools under the jurisdiction of the Transvaal Education Department are female. The professionalism, work motivation and work satisfaction of female teachers are often questioned possibly owing to the ostensible discriminatory conditions of service meted out to female teachers. In this research it is postulated (and confirmed by the literature study) that a distinct set of needs applies to female teachers. It is important for the leaders in education, (e.g. headmasters, heads of department) to be conversant with these special needs which may influence female teachers' motivation to work. The general aim of this research can therefore be related to the question: Which factors influence the female teacher's motivation to work? Specific aims of this research are inter alia: to determine - by means of a questionnaire - whether the female teacher's professional needs and aspirations are being met in education; to determine the discrepancy (if any) between the female teacher's needs and the satisfaction thereof; to identify factors to be remedied. 2. METHOD OF RESEARCH: A questionnaire, based on the study of relevant literature and encompassing the same needs as those of the Minnesota Importance Questionnaire was designed, but with the additional purpose to determine also the extent to which these needs are being satisfied in education. Twenty-seven of the 24 7 secondary schools under the jurisdiction of the Transvaal Education Department were selected at random and the research sample consisted of all 806 female teachers attached to these schools. The empirical data was statistically processed by means of a CHAID analysis. 3. INTERPRETATION OF EMPIRICAL DATA: Female teachers who participated in this research indicated the need for an amicable relationship with their pupils as the need which motivated them to harder work. The need for compatibility between their role as mother/homemaker and their role as teacher featured strongly in the responses. Needs relating to the need for compatibility of roles, such as the need for a fair work load, the need for fair working hours (extramural activities and preparation included) were rated highly. Extrinsic needs such as salary and security were also regarded as fairly important. The empirical data reveals that the female teacher's social needs are sufficiently satisfied. Extrinsic needs such as security, fair application of school policy and reasonable supervision are also satisfied. Needs which enjoy little or no satisfaction relate to administrative or policy aspects of education such as salary, fair evaluation for merit and promotion, participation in decision-making and the need for a fair work load. Female heads of department experienced more work satisfaction and satisfaction of their needs than teachers on post level 1. Female teachers in temporary posts showed a significant lack of motivation. English speaking teachers were significantly less satisfied with the application of school policy. Afrikaans-speaking female teachers' need to achieve and their need for more authority were significantly less satisfied than those of their English-speaking counterparts. Married female teachers were more satisfied with their salaries, but those with pre-school children experienced less satisfaction with regard to their extramural involvement and were more dissatisfied with their work load. A significant number of female teachers indicated (unnecessary) administrative work as a demotivating factor. 4. CONCLUSION: Most female teachers are not satisfied with extrinsic factors such as salary (especially the disparity between the salary of male and female teachers) . Extrinsic factors, however, do not contribute directly towards the female teacher's relationship with her pupils, her pride in her work, her self-esteem, and her love for her particular subject - these are the factors which really determine her motivation. The married female teacher's circumstances at home will determine her career commitment and influence her motivation to work.
Thesis (MEd)--PU vir CHO, 1989

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Harmon, Andrew James. „Collision study for the one-way IVDS channel“. Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-06082009-170949/.

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Franks, Steven Craig. „IVDS System: Channel Simulation and Repeater Unit Design“. Thesis, Virginia Tech, 1996. http://hdl.handle.net/10919/35438.

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In this thesis, an Interactive Video Data Service (IVDS) is developed. This service provides a mechanism for television viewers to interact with the program they are watching. Possible interactions include purchasing products from home shopping programs and requesting information from advertisers. Within the project, two areas were focused upon: channel simulation and the Repeater Unit. Additionally, the overall system was discussed along with its background. The purpose of channel simulation was to demonstrate the viability of the unique communication channel model proposed for the IVDS system. This channel was implemented using uni-directional transmissions, without acknowledgments. The Repeater Unit was designed to be a message processing system, intended to relay messages from system users to the home office. The design entailed both hardware and software. The hardware requirements were for a high level design, while the software required not only design, but implementation.
Master of Science

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Gašpar, Tomáš. „Fúze a akvizice v IVD“. Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-113120.

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The essential goal of the thesis is to confirm or reject the hypothesis that mergers and acquisitions are an effective way how to grow the value of a company, especially in the regulated environment of the Czech healthcare. The theses focuses mainly on human IVD laboratories though the most of the content relates to the healthcare as a whole. On one hand the theses offers a view of the pure theory of M&A's, on the other hand its connection to reality.The basic processes are the definition of the IVD market, analyses of the sources of income in the healthcare in relation to the possibilities of company value growth. At the end of the thesis the hypothesis is verified by a real lab acquisition case.

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Wersäll, Margareta. „Fattighusliv i ensamhetsslott : Ivar Lo-Johansson och de äldre i samhällsdebatt och dikt /“. [S.l. : Uppsala : s.n.] ; Uppsala University [Host], 2006. http://www.diva-portal.org/diva/getDocument?urn_nbn_se_uu_diva-6934-1__fulltext.pdf.

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Smeds, Fredrik. „Integralekvationer“. Thesis, Karlstad University, Division for Engineering Sciences, Physics and Mathematics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4104.

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Denna skrift är huvudsakligen en översättning av delar av kompendiet Integral Equations av Yury V. Shestopalov och Yury G. Smirnov (Karlstads universitet 2002), till vilken jag bifogat några egna exempel och en biografi över Ivar Fredholm. Skriften är författad i början av 2005, då jag läste kursen "Integralekvationer" för Yury Shestopalov.

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Burch, Richard Lee. „Interactive Video & Data Services (IVDS) : a cellular overlay concept /“. Master's thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-10242009-020144/.

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Bücher zum Thema "IVDR"

Davies, Ivor. Ivor Davies. London: Jane Roberts - Max Rutherston, 1989.

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ill, Larson Melissa, Hrsg. Iver & Ellsworth. Portland, OR: Ripple Grove Press, 2018.

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Ivor Novello. London: W.H. Allen, 1987.

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Ivor Gurney. Devon, UK: Northcote House in association with the British Council, 2001.

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Jørgen, Lund, und Museet for samtidskunst (Norway), Hrsg. Iver Jåks. Oslo: Riksutstillinger, 1998.

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Harding, James. Ivor Novello. London: W.H. Allen, 1987.

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Ivar Arosenius. Stockholm: Bokförlaget Signum, 2009.

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George, Walter, Hrsg. Ivor Gurney. London: Everyman, 1996.

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Calling Doctor Iver. Bath, England: Chivers Press, 1991.

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Ke, Sānu Eṃ. Ivar lōkatte snēhiccavar. Tiruvanantapuraṃ: Pr̲abhāt Bukk Haus, 1999.

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Buchteile zum Thema "IVDR"

O’Regan, Gerard. „Ivar Jacobson“. In Giants of Computing, 153–58. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-5340-5_33.

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Clikeman, Paul M. „Ivar Kreuger“. In Called to Account, 21–26. Third edition. | Abingdon, Oxon ; New York, NY : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9780429449475-4.

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Jansen, Joy. „Lovaas, Ole Ivar“. In Encyclopedia of Child Behavior and Development, 902. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-79061-9_1690.

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Lovie, P., und A. D. Lovie. „Hovland, Carl Iver.“ In Encyclopedia of psychology, Vol. 4., 167–68. Washington: American Psychological Association, 2000. http://dx.doi.org/10.1037/10519-075.

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Kolb, Charles C. „Noël Hume, Ivor“. In Encyclopedia of Global Archaeology, 1–3. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-51726-1_1749-2.

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Kolb, Charles C. „Noël Hume, Ivor“. In Encyclopedia of Global Archaeology, 1–3. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-51726-1_1749-3.

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Elmadhun, Nassrene Y., und Manjit S. Bains. „Ivor Lewis Esophagectomy“. In Esophageal Cancer, 91–97. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-91830-3_10.

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Hoff, Karin. „Lo-Johansson, Ivar“. In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_15371-1.

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Lewis, Moira, Courtenay Norbury, Rhiannon Luyster, Lauren Schmitt, Andrea McDuffie, Eileen Haebig, Donna S. Murray et al. „Lovaas, O. Ivar“. In Encyclopedia of Autism Spectrum Disorders, 1765–68. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_1298.

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Eikeseth, Svein, und Tristram Smith. „Lovaas, O. Ivar“. In Encyclopedia of Autism Spectrum Disorders, 1–4. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-6435-8_1298-3.

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Konferenzberichte zum Thema "IVDR"

Musicant, Oren, Haneen Farah, Tomer Toledo, Yaara Shimshoni, Haim Omer und Tsippy Lotan. „The Potential for IVDR Feedback and Parental Guidance to Improve Novice Young Drivers’ Behavior“. In Driving Assessment Conference. Iowa City, Iowa: University of Iowa, 2013. http://dx.doi.org/10.17077/drivingassessment.1464.

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Parker, Ricardo J., Michael Myers und Patric Schiltz. „Abstract 5448:In vitrodrug response (IVDR), biomarkers (BM) and clinical outcome (CO) in malignant glioma (GM) patients“. In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5448.

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Parker, Ricardo J., Patric M. Schiltz und Michael P. Myers. „Abstract 4159:In vitrodrug response (IVDR) and tumor-associated biomarker (BM) expression profiles in lung carcinoma (LC)“. In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4159.

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Korecki, Casey L., Benjamin A. Walter, Karolyn E. Godburn und James C. Iatridis. „Asymmetric Loading Promotes Early Signs of Intervertebral Disc Degeneration in Large Animal Organ Culture“. In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206491.

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Intervertebral disc (IVD) degeneration is a complex pathology, involving alterations in mechanical and biological function. Mechanical injury to IVDs may contribute to the development of IVD degeneration, and can arise following excessive loading or repeated exposure to loading levels which are not instantaneously damaging. Lateral bending and flexion produced the highest maximum shear strains in human IVDs and are considered the motions that place the IVD at greatest risk of injury (1). The biological response of the IVD to combined bending and compression has been examined in vivo in rat and mouse tail bending models demonstrating structural disruption, apoptosis and remodeling (2,4). However, there are practical limitations to current in vivo studies, as it can be difficult to apply repeated bending loads to the disc in vivo, and few large animal models exist capable of tracking the early biological, structural and compositional changes from asymmetrical loading. IVD organ culture allows control over mechanical boundary conditions and investigation of cellular responses to loading while the IVD remains largely intact, and allows the use of large animal models which more closely mimic the nutritional and compositional nature of human IVDs.

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Wang, Shaobai, Won Man Park und Guoan Li. „Noninvasive Prediction of the In Vivo Forces on the Lumbar Intervertebral Discs: A Validation Study“. In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53141.

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Evaluation of the forces on the lumbar intervertebral discs (IVDs) is critically important since it closely relates to biomechanics, pathology, prosthesis design and tissue engineering. It remains a big challenge to noninvasively predict the in vivo forces on the IVD. Using our previously established dual fluoroscopic imaging system (DFIS) [1], motion of the vertebrae can be accurately obtained. We proposed to use the kinematics from DFIS as inputs into FE model to calculate the forces on the IVD. In this study, we validated the technique by testing an IVD on a 6DOF robotic system under applied loads and under DFIS. A subject specific FE model of IVD was built. Forces and moments were predicted and compared to the applied loads.

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Michalek, Arthur J., und James C. Iatridis. „An Analytical Model Describing Intervertebral Disc Mechanics Following a Needle Puncture Injury“. In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206493.

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There is growing acceptance of needle puncture injury to induce intervertebral disc (IVD) degeneration in small animal models, and needle injection is the most likely pathway for delivery of growth factors and/or cell therapies to IVDs. Consequently, there is strong motivation for improved understanding of how needle injuries affect IVD mechanics. Loss of disc height and stiffness have been shown following needle puncture [1,2,3], yet the exact mechanisms by which a needle puncture alters disc mechanics are unclear. This study aims to develop an analytical model of the IVD which may be used to assess the relative contributions of various load carriage mechanisms to overall disc properties.

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Zhu, Qiaoqiao, und Weiyong Gu. „Effects of Dynamic Loading on Cell Viability in Intervertebral Disc“. In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80452.

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Sufficient nutrient supply has long been regarded as a crucial factor for maintaining intervertebral disc (IVD) cell viability and preventing IVD degeneration1,2. Due to avascular nature of the tissue, nutrients for IVD cells are transported, mainly by diffusion, through the dense extracellular matrix of the tissue from the peripheral and endplate vasculatures. Experimental studies on the effects of nutrient deprivation on IVD cell viability showed that glucose is the most critical nutrient affecting the cell density in IVD3–5. Because of the difficulties in studying mechano-biology of human IVD in vivo, numerical simulations are necessary to investigate how the disturbances of biological, physical, and chemical signals can affect the cellular metabolism and viability in IVD. However, to date, there is no adequate theoretical model that is able to describe the change of cell density in IVD under dynamic conditions. Therefore, the objective of this study was to develop a new constitutive model for cell growth/death in human IVD and to analyze the cell metabolism and cell viability in IVD under dynamic, mechanical loading conditions using numerical methods based on the mechano-electrochemical mixture theory6,7.

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Peloquin, John M., Jonathon H. Yoder, Nathan T. Jacobs, Sung M. Moon, Alexander C. Wright, Edward J. Vresilovic und Dawn M. Elliott. „Intervertebral Disc Shape Variation and its Relationship to Degeneration Using Principal Components Analysis of a Population of MR Images“. In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80645.

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Degeneration of the intervertebral disc (IVD) is implicated in low back pain, which is a costly and prevalent disease. Since the IVD is a mechanically active organ, it is important to consider its mechanical behavior as one factor in the degenerate pathology. Strain can be measured directly by imaging methods, but the stress distribution within the disc must be calculated. The stress distribution for a particular strain state is dependent on the IVD’s material properties and its geometry. While the material properties of the tissues comprising IVD have been extensively studied, its three-dimensional geometry remains incompletely characterized. Prior whole-disc models have been constructed from single IVDs. While this approach ensures that the geometry has a physiological basis, it is uncertain the degree to which results from a single IVD shape can be generalized to the entire population.

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Chahine, Nadeen, Nate Stetson, Neena Rajan, Daniel Grande und Mitchell Levine. „Recovery of Intervertebral Disc Degeneration Post Enzymatic Treatment is Mediated by Matrix Metalloproteinases“. In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53887.

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Enzymatic degradation of the intervertebral disc (IVD) with chondroitinase ABC (ChABC) reduces proteoglycan content of the IVD, thus simulating the GAG loss seen clinically in patients suffering from disc degeneration. This approach has been employed in models of disc injury in rats, rabbits and goats when administered over a large range of dosages [1–3]. Moreover, ChABC has also been used to induce repair of herniated discs in rabbits via chemonucleolysis [4, 5]. Despite the effectiveness of ChABC treatment to reduce the GAG content of the IVD, several recent studies including our own, have shown that this GAG loss is reversible at extended time points post enzymatic treatment [2,6,7]. The goal of the current study is to examine the dose dependent response of IVDs to degradation by ChABC in vivo. We hypothesize that administration of ChABC will result in dose dependent GAG loss and reduced mechanical properties. We administered ChABC at 0.1 U/ml, 1.0 U/ml and 10 U/ml and examined the changes in biomechanical properties, biochemical content, and gene expression in order to examine the biophysical and molecular mechanism by which GAG loss occurs in this model.

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Cannanure, Vikram Kamath, und Timothy X. Brown. „RASP-IVR“. In AfriCHI '18: 2nd African Conference for Human Computer Interaction. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3283458.3283489.

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Berichte der Organisationen zum Thema "IVDR"

Brand, Marissa, Gerald Key, J. T. Nohara, Robert Beason, Ed Herricks, Ryan King, Jr Gauthreaux et al. Integration and Validation of Avian Radars (IVAR). Fort Belvoir, VA: Defense Technical Information Center, Juli 2011. http://dx.doi.org/10.21236/ada555979.

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Wick, Charles H., und Patrick E. McCubbin. Capillary Diameter Variation for the Integrated Virus Detection System (IVDS). Fort Belvoir, VA: Defense Technical Information Center, Oktober 2010. http://dx.doi.org/10.21236/ada531909.

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Wick, Charles H., und Patrick E. McCubbin. Characterization of MS2 Bacteriophage by Integrated Virus Detection System (IVDS) Physical Counting Methodology. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada368542.

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Wick, Charles H., und Patrick E. McCubbin. Malvern Nano ZS Particle Size Comparison with the Integrated Virus Detection System (IVDS). Fort Belvoir, VA: Defense Technical Information Center, März 2010. http://dx.doi.org/10.21236/ada516725.

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Wick, Charles H., Ilya Elashvili, Patrick E. McCubbin und Amnon Birenzvige. Determination of MS2 Bacteriophage Stability at Low pH Using the Integrated Virus Detection System (IVDS). Fort Belvoir, VA: Defense Technical Information Center, September 2006. http://dx.doi.org/10.21236/ada457329.

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McGlashan, S., T. Melanchuk und C. Boulton. An Interactive Voice Response (IVR) Control Package for the Media Control Channel Framework. RFC Editor, Mai 2011. http://dx.doi.org/10.17487/rfc6231.

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Brand, Marissa, Gerald Key, Ed Herricks, Ryan King, J. T. Nohara, Jr Gauthreaux, Begier Sidney et al. Integration and Validation of Avian Radars (IVAR): Functional Requirements and Performance Specifications for Avian Radar Systems. Version 3.0. Fort Belvoir, VA: Defense Technical Information Center, Dezember 2011. http://dx.doi.org/10.21236/ada581966.

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Jennings, C., F. Audet und J. Elwell. Session Initiation Protocol (SIP) URIs for Applications such as Voicemail and Interactive Voice Response (IVR). RFC Editor, April 2006. http://dx.doi.org/10.17487/rfc4458.

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