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Zeitschriftenartikel zum Thema "IORP II"

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Bubnova, Irina, Veronica Averich und Elena Belousova. „Influence of corneal biomechanical properties on IOP indices in patients with keratoconus“. Eye 21, Nr. 128 (Dezember 2019): 15–19. http://dx.doi.org/10.33791/2222-4408-2019-4-15-19.

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Purpose: Evaluation of corneal biomechanical prop¬erties and their influence on IOP indices in patients with keratoconus. Material and methods. The study included 194 eyes with keratoconus (113 patients aged from 23 to 36 years old). Corneal refraction in central zone varied from 48.25 to 56.75 D, values of corneal thickness ranged from 279 to 558 μm. Patients were divided into 4 groups according to Amsler classification: I stage – 40 eyes; II stage – 78 eyes; III stage – 54 eyes and IV stage – 22 eyes. Standard ophthal¬mological examination was carried out including pneumo¬tonometry. IOP indices and values of biomechanical prop¬erties were evaluated by dynamic bidirectional pneumatic applanation and pneumatic impression. Results. Study of corneal biomechanical properties in patients with keratoconus showed a decrease of such biomechanical indices as corneal hysteresis (CH) on aver¬age to 8.42±1.12 mm Hg, corneal resistance factor (CRF) – to 7.45±0.96 mm Hg, coefficient of elasticity (CE) – 5.35± 0.87 mm Hg. Values of these indices strongly depended on the stage of keratoconus. In the whole sample, the aver¬age corneal compensated IOP (IOPcc) amounted to 15.08± 2.43 mm Hg, Goldman IOP (IOPg) was 11.61±2.37 mm Hg and pneumatic tonometry IOP (IOPp) was 10.13±2.94 mm Hg. IOPcc indices didn’t have any statistically significant differ¬ence in dependence on the stage of keratoconus (р>0.473), while in process of disease progression IOPg and IOPp indi¬ces showed statistically significant decrease of mean values. Conclusion. Progression of keratoconus led to a de¬crease in corneal biomechanical properties which deter¬mine reduction of such indices as IOPg and IOPp in contrast to IOPcc.
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Skrzypecki, Janusz, Karolina Niewęgłowska und Emilia Samborowska. „Valeric Acid, a Gut Microbiota Product, Penetrates to the Eye and Lowers Intraocular Pressure in Rats“. Nutrients 12, Nr. 2 (31.01.2020): 387. http://dx.doi.org/10.3390/nu12020387.

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Mechanisms controlling intraocular pressure (IOP) and arterial blood pressure (BP) share similar mediators, including gut bacteria metabolites. Here, we investigated the effects of valeric acid (VA), a short chain fatty acid produced by microbiota from undigested carbohydrates, on IOP and BP. To test if gut VA penetrates to the eye we evaluated eyes’ homogenates after the administration of D9-VA into the colon. Additionally, the following experimental series were performed on 16-week-old Sprague Dawley rats to analyze the influence of VA on IOP: vehicle treatment; VA treatment; VA + hydroxybutyrate - a short chain fatty acids’ G protein-coupled receptor 41/43 (GPR 41/43) blocker (ANT); hydroxybutyrate; VA + angiotensin II; angiotensin II; VA treatment in rats with superior cervical ganglion excision and sham operated rats. D9-VA rapidly penetrated from the colon to the eye. VA significantly decreased IOP and BP. The decrease in IOP was gradual and lasted through the experiment. In contrast, a decrease in BP was instantaneous and lasted no longer than 10 min. Angiotensin II, ANT, and sympathetic denervation did not influence the effect of VA on IOP. In conclusion, colon-derived VA penetrates to the eye and decreases IOP. The effect is independent from BP changes, angiotensin II, GPR41/43, and sympathetic eye innervation.
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Talabi, Oluwole A., und Zhen-Xuan Yew. „Modifying the Hall Plot for Analysis of Immiscible Gas Injection Wells II: IOR“. International Journal of Chemical Engineering and Applications 9, Nr. 2 (April 2018): 46–50. http://dx.doi.org/10.18178/ijcea.2018.9.2.697.

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Енукашвили, Н. И., И. Е. Коткас, Д. С. Боголюбов, А. В. Котова, И. О. Боголюбова, В. В. Багаева, К. А. Левчук et al. „Детектирование клеток, содержащих интернализованные мультидоменные магнитные наночастицы оксида железа (II, III), методом магнитно-резонансной томографии“. Журнал технической физики 90, Nr. 9 (2020): 1418. http://dx.doi.org/10.21883/jtf.2020.09.49671.402-19.

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This study evaluated the feasibility of using uncoated iron (II, III) oxide nanoparticles (IONP) obtained by electric explosion of wire in air for labelling living mesenchymal stromal cells and their subsequent visualization by magnetic resonance imaging (MRI) using 1.5T clinical MRI scanners. The uptake of uncoated IONP by MSC was demonstrated for the wide range of IONP concentration in the cell culture medium. The cells did not change their proliferative activity, viability, and the set of surface markers. IONP obtained by electric explosion of wire in an atmosphere of air had a shape close to spherical. The size of nanoparticles varied from 14 to 136 nm according to dynamic lateral light scattering, laser diffraction, and transmission electron microscopy. Particles up to 136 nm comprised 75%, and particles less than 36 nm --- 10% of the IONP powder. A wide range of particle sizes made it possible to select MRI parameters suitable for labelled cells detection in animal tissues both in the T2 mode and in the T1 relaxation mode.
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Konopińska, Joanna, Milena Kozera, Paweł Kraśnicki, Zofia Mariak und Marek Rękas. „The Effectiveness of First-Generation iStent Microbypass Implantation Depends on Initial Intraocular Pressure: 24-Month Follow-Up—Prospective Clinical Trial“. Journal of Ophthalmology 2020 (23.06.2020): 1–8. http://dx.doi.org/10.1155/2020/8164703.

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Background. Evaluation of efficacy of the iStent trabecular bypass implant in reducing intraocular pressure (IOP) depending on the value pretreatment IOP and number of medications used before surgery in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) and coexisting cataract. Methods. A prospective, uncontrolled, interventional case series. 72 patients, on a mean age of 72.42 ± 9.17, were divided into two groups depending on baseline IOP: group I < 26 mmHg and group II ≥ 26 mmHg. All subjects underwent ab interno implantation of a single iStent together with cataract surgery. Best-corrected visual acuity (BCVA), IOP, number of antiglaucoma medications, visual field, and number and type of complications were examined before and after surgery. Postoperative patients were followed up at 1, 7, and 30 days and 3, 6, 12, and 24 months. All the patients were washed out preoperatively as well as postoperatively. Results. The mean observation time was 20 months. The mean preoperative IOP was 21.03 ± 1.44 mmHg in group I and reduced to mean 15.60 ± 2.12 mmHg after operation. In group II, mean IOP reduced from 26.00 ± 0.00 to 18.56 ± 1.81 (p=0.003). Mean glaucoma medications decreased from 1.35 ± 0.65 to 0.29 ± 0.52 in group I (p<0.001) and from 2.89 ± 1.18 to 1.33 ± 1.50 in group II (p<0.001). At 24 months, medication reduction was significantly greater in group I than group II (p=0.026). Conclusions. Combined cataract surgery with implantation of iStent seems to be an effective procedure in patients with mild-to-moderate open-angle glaucoma and cataract. In patients with baseline IOP < 26 mmHg, surgery reduced IOP and medication use significantly declined to 2 years, with greater reductions achieved versus patients with baseline IOP ≥ 26 mmHg. This trial is registered with NCT03807869.
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Ramdas, Yastira, Carol-Ann Benn, Alexandra Grubnik, Yasmin Mayat und Dennis R. Holmes. „Targeted Intraoperative Radiotherapy Is a Safe Approach for Patients with Pacemakers: A Case Study and Literature Review“. Case Reports in Oncology 13, Nr. 2 (30.07.2020): 916–22. http://dx.doi.org/10.1159/000508946.

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Case reports detailing the effects of targeted intraoperative radiation therapy (IORT) on patients with cardiac pacemakers (PMs) are rare. This growing population sub-group requiring IORT and lack of standardized guidelines necessitate more practical published research. An 81-year-old patient with clinical stage II, T1 N0 grade III, triple-negative invasive ductal carcinoma and an implanted single-lead chamber PM (VVIR mode, model: Biotronik, type Effecta SR) received targeted intraoperative radiotherapy at the time of wide local excision and sentinel lymph node biopsy. It presents the shortest distance between the outer diameter of the PM and IORT applicator in literature. Target IORT was performed utilizing an Intrabeam device (50 kV, Carl Zeiss Surgical, Oberkochen, Germany). This case elucidates the successful use of targeted IORT for breast-conserving surgery in a patient with a single ipsilateral chamber VVIR mode PM. No device failure or malfunction was reported for the PM before, during, or after the procedure. These findings support the use of targeted IORT for patients diagnosed with early-stage breast carcinomas who have a PM implanted. However, further research is needed to understand the safety of other methods and devices for IORT patients with cardiac implantable electronic devices.
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Eti, Z., A. Yayci, T. Umuroǧlu, F. Y. Göǧüş und N. Bozkurt. „The Effect of Propofol and Alfentanil on the Increase in Intraocular Pressure Due to Succinylcholine and Intubation“. European Journal of Ophthalmology 10, Nr. 2 (April 2000): 105–9. http://dx.doi.org/10.1177/112067210001000202.

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Purpose The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide. Methods Forty patients aged 20–50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group I, 2.5 mg/kg propofol and 10 μg/kg alfentanil in Group II and 5 mg/kg thiopental in Groups III and IV; muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Group I, II and III) or 0.1 mg/kg vecuronium bromide (Group IV). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation. Results Compared with their baseline values in Group I IOP decreased significantly after propofol (p<0.01) and increased significantly after intubation (p<0.01). In Group II IOP decreased significantly after propofol and alfentanyl (p<0.001), remained low after succinylcholine (p<0.01) and did not change after intubation. In Group III IOP decreased significantly after thiopental (p<0.001) and increased significantly after intubation (p<0.001). In Group IV it decreased significantly after thiopental (p<0.001), remained low after vecuronium (p<0.001) and increased significantly after intubation (p<0.05). Conclusions In all Groups, IOP did not increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.
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Supuran, Claudiu T., Andrea Scozzafava und Andrei Jitianu. „Carbonic Anhydrase Inhibitors. Part 541: Metal Complexes of Heterocyclic Sulfonamides: A New Class of Antiglaucoma Agents“. Metal-Based Drugs 4, Nr. 6 (01.01.1997): 307–15. http://dx.doi.org/10.1155/mbd.1997.307.

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Metal complexes of heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties were recently shown to be useful as intraocular pressure (IOP) lowering agents in experimental animals, and might be developed as a novel class of antiglaucoma drugs. Here we report the synthesis of a heterocyclic sulfonamide CA inhibitor and of the metal complexes containing main group metal ions, such as Be(II), Mg(II), Al(III), Zn(II), Cd(II) and Hg(II) and the new sulfonamide as well as 5-amino-1,3,4-thiadiazole-2-sulfonamide as ligands. The new complexes were characterized by standard physico-chemical procedures, and assayed as inhibitors of three CA isozymes, CA I, II and IV. Some of them (but not the parent sulfonamides) strongly lowered IOP in rabbits when administered as a 2% solution into the eye.
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Fujii, T., S. Nagai, Y. Kodera, M. Kanda, T. T. Sahin, H. Sugimoto, S. Nomoto, S. Takeda, S. Morita und A. Nakao. „Prognostic implication of intraoperative radiotherapy for unresectable pancreatic cancer.“ Journal of Clinical Oncology 29, Nr. 4_suppl (01.02.2011): 346. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.346.

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346 Background: There is no established treatment strategy for unresectable pancreatic cancer, and the prognostic effect of intraoperative radiotherapy (IORT) is considered to be limited. Methods: We reviewed 614 surgical cases of pancreatic cancer and selected 198 cases that did not undergo pancreatectomy because of distant metastasis or locally advanced disease, at the Department of Surgery II, between July 1981 and June 2009. Liver metastasis was observed in 70 patients and peritoneal metastasis in 44. Treatment for those who were feasible consisted of IORT and/or postoperative chemotherapy. Overall survival and prognostic factors were evaluated for all patients and for each pattern of disease spread. Results: IORT was performed in 120 patients (61%), and chemotherapy was indicated in 80 (40%). Overall survival in the non-treatment group was significantly inferior to that for IORT alone and IORT plus gemcitabine (GEM)-based chemotherapy (median survival time: 3.2 months vs. 6.1 and 7.9 months; P = 0.0001 and <0.0001, respectively). After multivariate analysis, IORT and GEM-based chemotherapy were identified as independent prognostic factors [hazard ratio (HR) = 0.51, P < 0.001; HR = 0.43, P < 0.001]. IORT was an independent prognostic determinant for patients with peritoneal metastasis (HR = 0.24, P = 0.011), whereas it was not for those with liver metastasis (HR = 0.78, P = 0.381). Conclusions: The prognostic value of IORT is most prominent in the peritoneal disease. IORT followed by GEM-based chemotherapy is possibly one of the most recommended treatment strategies in unresectable pancreatic cancer. No significant financial relationships to disclose.
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Giordano, F., S. Brehmer, B. Mürle, G. Welzel, E. Sperk, A. Keller, Y. Abo-Madyan et al. „PO-0632: Phase I/II Trial on Intraoperative Radiotherapy (IORT) in Glioblastoma Multiforme (INTRAGO I/II)“. Radiotherapy and Oncology 123 (Mai 2017): S330—S331. http://dx.doi.org/10.1016/s0167-8140(17)31069-1.

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Dissertationen zum Thema "IORP II"

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Özgünes, Alp. „An analysis of Directive IORP II“. Master's thesis, Instituto Superior de Economia e Gestão, 2015. http://hdl.handle.net/10400.5/11521.

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Mestrado em Ciências Actuariais
O objetivo do presente Trabalho Final de Mestrado baseia-se na adoção de normas de Solvência II em fundos de pensões de benefício definido (BD). Apesar de já se ter obtido um consenso relativamente à não aplicação da proposta de Diretiva Solvência II aos fundos de pensão, que são abrangidas pela Diretiva do Conselho 2003/41/CEE, a questão sobre a adoção de padrões de capitalização de estilo Solvência II para DB fundos de pensão entrou na agenda da Comissão Europeia. Neste estudo nós tentamos explorar e fazer alguma análise crítica em relação proposta para a nova Directiva IORP II. Nos primeiros capítulos, familiarizamos os leitores sobre sistema de previdência complementar e os projetos de solvência na UE. Mais tarde, analisamos a proposta de directiva IORP II e descrevemos os riscos, a que os fundos de pensão estão expostos, em seguida, procuramos modelar algumas análises de solvência para fundos de pensões. No final do estudo, tentamos analisar os impactos das normas que são propostas pela nova Directiva IORP II, sobre um fundo de pensão selecionado através da realização de um case study. Neste propósito, assumimos alguns pressupostos, e efetuamos o estudo com dados examplo.
The objective of the following Master's Final Work is based on the adoption of Solvency II-style capitalization standards to defined benefit (DB) pension funds. Even if a consensus has already been reached, and the proposed Solvency II Directive does not apply to pension funds, which are covered by the Directive 2003/41/EEC, the idea of adoption of Solvency II-style capitalization standards to DB pension funds also has been entered to the European Commission's agenda. In this study we try to explore and make some criticism about the proposed new IORP II Directive. In the first chapters we acquaint readers about pension fund system and solvency projects in EU. Later we analyse the proposed IORP II directive and clarify the risks, which the pension funds are exposed, then try to model solvency figures of the pension funds. As a final of the study, we try to analyse the impacts of the capitalization standards, which are proposed by the new IORP II Directive, on the selected pension fund by conducting a case study. In this purpose, we assume some assumptions, and study with sample data.
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Strid, Ebba, und Wedin Ida Nylander. „Implementering av den nya tjänstepensionsregleringen: Utmaningar och långsiktiga effekter“. Thesis, Mittuniversitetet, Institutionen för ekonomi, geografi, juridik och turism, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-42372.

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Tjänstepensionen spelar en viktig roll i frågan om hur livet kommer att se ut efter att vi slutat arbeta. Sedan finanskrisen 2007–2009 har en stor tillsyns- och regleringsreform lagts fram inom Europeiska unionen (EU) och nu har det implementerats en ny reglering för företag som bedriver tjänstepensionsverksamhet. Tidigare forskning har konstaterat att finansiell reglering är nödvändig och måste finnas i samhället för att kunna säkerställa ett stabilt finansiellt system. Dock leder ofta införandet av nya regleringar som innefattar högre krav också till oförutsedda utmaningar och oönskade effekter. Studien syftar till att beskriva och analysera hur reglering kan tas emot av företag som bedriver tjänstepensionsverksamhet och eventuella skillnader mellan regleringens avsikt och hur den sedan upplevs av företagen. Studien genomfördes med en kvantitativ del i form av en enkätundersökning riktad till företag med tjänstepensionsverksamhet samt en kvalitativ del i form av en dokumentstudie av regeringens konsekvensanalys avseende den nya tjänstepensionsregleringen. Metodkombinationen gjorde det möjligt att belysa och analysera företagsrepresentanternas upplevelser och syn på den nya regleringen samt att jämföra de med regeringens konsekvensanalys. Studiens resultat gav en insikt i att avsikten med nya regleringar inte alltid stämmer överens med hur företagen upplever det. Resultatet indikerade också att ingen av den nya tjänstepensionsregleringens delar ansågs särskilt utmanande för företagsrepresentanterna samt att det inte visades någon förväntan på att den nya tjänstepensionsregleringen kommer att leda till positiva långsiktiga effekter. Av studien kunde också ett positivt samband skönjas mellan utmaningar och långsiktiga effekter som indikerade att en mer utmanande implementeringsprocess ökade förtroendet för att regleringen ska leda till positiva långsiktiga effekter.
The occupational pension plays an important role for how our life will appear when we stop working. There has been a huge reformation of the regulation in the European Union (EU) since the financial crises 2007-2009. Now, a new regulation for companies with occupational pension also has been introduced. Previous research has determined that financial regulation is necessary and must be a part of the society to secure a steady financial system. However, new regulations with higher requirements often leads to unexpected challenges and unhoped affects. The study aims to describe and analyze how regulation can be received by companies that conduct occupational pension activities and any differences between the intention of the regulation and how it is then experienced by the companies. The research used both a quantitative approach through an online survey to collect data from companies with occupational pension and a qualitative approach through a study of the government’s consequence-analysis. This method combination gave an opportunity to clarify and analyze the company representatives’ thoughts about the new regulation and compare those with the government’s consequence-analysis. The result of the study provided an insight into the fact that the intention with new regulations does not always correspond to how companies experience it. The result also indicated that the representatives from the companies did not found the new regulation especially challenging and that they did not show any expectation for positive long-term effects from the regulation. The study also showed a positive relationship between challenges and long-term effects, which indicated that a more challenging implementation process increased confidence that the regulation would lead to positive long-term effects.
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Buchteile zum Thema "IORP II"

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Reiner, Michael. „Strukturfragen zum Zusammenspiel von Aufsichts- und Arbeitsrecht im europäischen Pensionsfondsgeschäft gemäß IORP II“. In Arbeitsrecht und Arbeitswelt im europäischen Wandel, 193–216. Nomos Verlagsgesellschaft mbH & Co. KG, 2016. http://dx.doi.org/10.5771/9783845272269-192.

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Johnson, K., R. Waldman und K. M. Marsaglia. „Data report: sedimentary columns with facies and bedding for Units II-IV at IODP Site U1438“. In Proceedings of the International Ocean Discovery Program. International Ocean Discovery Program, 2017. http://dx.doi.org/10.14379/iodp.proc.351.201.2017.

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Konferenzberichte zum Thema "IORP II"

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Kadeethum, T., H. K. Sarma, B. B. Maini und C. Jaruwattanasakul. „Enhance Microscopic Sweep Efficiency by Smart Water in Tight and Very Tight Oil Reservoirs Part II“. In IOR 2017 - 19th European Symposium on Improved Oil Recovery. Netherlands: EAGE Publications BV, 2017. http://dx.doi.org/10.3997/2214-4609.201700264.

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Kadeethum, T., H. K. Sarma, B. B. Maini und C. Jaruwattanasakul. „Overcome Viscous Fingering Effect in Heavy Oil Reservoirs by an Optimized Smart Water Injection Scheme Part II“. In IOR 2017 - 19th European Symposium on Improved Oil Recovery. Netherlands: EAGE Publications BV, 2017. http://dx.doi.org/10.3997/2214-4609.201700252.

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Hassan, Anas M., Mohammed Ayoub, Mysara Eissa, Hans Bruining, Abdullah Al-Mansour und Abdulrahman Al-Quraishi. „A New Hybrid Improved and Enhanced Oil Recovery IOR/EOR Process Using Smart Water Assisted Foam SWAF Flooding in Carbonate Rocks; A Laboratory Study Approach“. In International Petroleum Technology Conference. IPTC, 2021. http://dx.doi.org/10.2523/iptc-21381-ms.

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Abstract Given the increasing demand for energy globally and depleting oil and gas resources, it is crucial to increase the production from existing reservoirs by introducing new technologies for Improved/Enhanced Oil Recovery (IOR/EOR). This contribution presents a novel hybrid IOR/EOR method, which combines smart water (SW) and foam flooding, known as Smart Water Assisted Foam (SWAF) flooding. The optimal conditions of the SWAF technology will be interpreted using experimental laboratory design (i.e., experimental data). The experimental design was divided into three main steps. The first step is obtaining rock wettability measurements using contact angle measurements. This step aims to select the optimum SW composition that changes the carbonate rock's wettability from oil-wet towards more water-wet and faster oil recoveries. The water-wet condition leads to high residual oil saturations and low end-point permeabilities. This is conductive to favourable mobility ratios and efficient water-oil displacement. However, high residual oil saturations are unfavourable to the high ultimate oil recovery as much oil stays behind. Secondly, the chemical screening follows, where two tests were performed, viz., (i) an Aqueous Stability Test (AST), (ii) and a Foamability and Foam Stability Tests (FT/FST). This step aims to generate a stable foam (i.e., surfactant aqueous solution + gas) in the absence and presence of crude oil with different TAN (Total Acid Number) and TBN (Total Base Number), viz., crude oils Type-A and Type-B. Favourable mobility ratio is achieved by the presence of foam, which leads to excellent displacement efficiency. Thirdly, core flooding tests are performed. This step aims to select the best formulations through SWAF core flooding tests to obtain the ultimate recovery factor under different injection scenarios. The optimal SWAF condition combines high ultimate recovery with the best displacement efficiency. It is shown that the enormous changes in wettability were seen for SW (MgCl2) solution at 3500 (ppm) for both crude oils Type-A and Type-B. It has been shown that the use of a cationic surfactant CTAB (i.e., cetyltrimethylammonium-bromide) in the positively charged carbonates (with an isoelectric point of pH = 9) is more effective than the use of anionic surfactant, e.g., Alpha Olefin Sulfonate (AOS). The aim is to create an optimum surfactant aqueous solution (SAS). The SAS stability is considerably affected by the concentration of both the SW (MgCl2) and surfactant (CTAB). In the absence of oil, the strength of foam (SAS and Gas) is highly dependent on the concentration and composition of the SW in the SAS. In the presence of oil, foam generation and stability are better when the crude oil has a low TAN and high TBN. From the core flooding tests for crude oils Type-A and Type-B, the ultimate residual oil recovery was achieved by the MgCl2 - foam injection combination (i.e., incremental oil recovery of 42%, which is equivalent to a cumulative oil recovery of 92%). In summary, SWAF under the optimum conditions is a promising method to increase the oil recovery from carbonate reservoirs.
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