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Auswahl der wissenschaftlichen Literatur zum Thema „Invertebrate Endocrine Disruption“
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Zeitschriftenartikel zum Thema "Invertebrate Endocrine Disruption"
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Layton, Scott, und Jason Belden. „Engaging Undergraduates in the Scientific Process: Exploring Invertebrate Endocrine Disruption“. American Biology Teacher 78, Nr. 5 (01.05.2016): 410–16. http://dx.doi.org/10.1525/abt.2016.78.5.410.
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Engaging students in the process of science to increase learning and critical thinking has become a key emphasis in undergraduate education. Introducing environmental topics, such as the effects of endocrine-disrupting chemicals, into undergraduate courses offers a new means to increase student engagement. Daphnia magna can serve as a model organism for endocrine disruption, and its ease of handling, rapid reproduction rate, and clearly defined endpoints make it useful in short-term, student research projects. The concept of endocrine disruption can be tested through a 21-day reproductive study of D. magna exposed to varying concentrations of the pesticide fenoxycarb. Students will observe an altered reproduction rate and increased production of males under conditions that would typically result only in the production of female offspring. This research system allows students to formulate hypotheses, set up experiments, analyze data, and present results, leading to a greater appreciation of and interest in science.
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Langston, W. J. „Endocrine disruption and altered sexual development in aquatic organisms: an invertebrate perspective“. Journal of the Marine Biological Association of the United Kingdom 100, Nr. 4 (Juni 2020): 495–515. http://dx.doi.org/10.1017/s0025315420000533.
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AbstractContaminants causing sex-altering, endocrine disrupting-like (ED) effects, or otherwise influencing reproduction, have been of growing concern to humans for more than 50 years. They have also been a perturbing, though less well-studied, phenomenon in marine organisms, following the recognition of tributyltin (TBT)-induced imposex and population extinctions in (neo)gastropods in the 1970s. Whilst ED impacts in mammals and fish are characterized by mimicry or antagonism of endogenous hormones by environmental contaminants (acting through Nuclear Receptors which are present in all metazoans) much less is known regarding pathways to effects in invertebrates. Despite the absence of a defined steroidal/mechanistic component, the extent, severity and widespread nature of ED-like manifestations and altered sexual characteristics observed in marine invertebrates gives rise to comparable concerns, and have been a long-term component of the MBA's research remit. The manifestations seen in sensitive taxa such as molluscs and crustaceans confirm they are valuable indicators of environmental quality, and should be exploited in this capacity whilst we seek to understand the pervasiveness and underlying mechanisms. In so doing, invertebrate indicators address aims of organizations, such as the EEA, OECD, UNEP and WHO, charged with management and monitoring of chemicals and ensuring that adverse effects on humans and the environment are minimized (Bergman et al., 2013). In view of the recent general declines in marine biodiversity, and the potential contribution of ED-like phenomena, safeguarding against deleterious effects through increased research which links pollutant exposure with reproductive dysfunction among invertebrates, is seen as a high priority.
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Keay, June, und Joseph W. Thornton. „Hormone-Activated Estrogen Receptors in Annelid Invertebrates: Implications for Evolution and Endocrine Disruption“. Endocrinology 150, Nr. 4 (26.11.2008): 1731–38. http://dx.doi.org/10.1210/en.2008-1338.
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As the primary mediators of estrogen signaling in vertebrates, estrogen receptors (ERs) play crucial roles in reproduction, development, and behavior. They are also the major mediators of endocrine disruption by xenobiotic pollutants that mimic or block estrogen action. ERs that are sensitive to estrogen and endocrine disrupters have long been thought to be restricted to vertebrates: although there is evidence for estrogen signaling in invertebrates, the only ERs studied to date, from mollusks and cephalochordates, have been insensitive to estrogen and therefore incapable of mediating estrogen signaling or disruption. To determine whether estrogen sensitivity is ancestral or a unique characteristic of vertebrate ERs, we isolated and characterized ERs from two annelids, Platynereis dumerilii and Capitella capitata, because annelids are the sister phylum to mollusks and have been shown to produce and respond to estrogens. Functional assays show that annelid ERs specifically activate transcription in response to low estrogen concentrations and bind estrogen with high affinity. Furthermore, numerous known endocrine-disrupting chemicals activate or antagonize the annelid ER. This is the first report of a hormone-activated invertebrate ER. Our results indicate that estrogen signaling via the ER is as ancient as the ancestral bilaterian animal and corroborate the estrogen sensitivity of the ancestral steroid receptor. They suggest that the taxonomic scope of endocrine disruption by xenoestrogens may be very broad and reveal how functional diversity evolved in a gene family central to animal endocrinology.
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Sainath, S. B., A. André, L. Filipe C. Castro und M. M. Santos. „The evolutionary road to invertebrate thyroid hormone signaling: Perspectives for endocrine disruption processes“. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 223 (September 2019): 124–38. http://dx.doi.org/10.1016/j.cbpc.2019.05.014.
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Puinean, Alin-Mirel, und Jeanette M. Rotchell. „Vitellogenin gene expression as a biomarker of endocrine disruption in the invertebrate, Mytilus edulis“. Marine Environmental Research 62 (Januar 2006): S211—S214. http://dx.doi.org/10.1016/j.marenvres.2006.04.035.
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Langston, W. J., G. R. Burt, B. S. Chesman und C. H. Vane. „Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment“. Journal of the Marine Biological Association of the United Kingdom 85, Nr. 1 (Februar 2005): 1–31. http://dx.doi.org/10.1017/s0025315405010787h.
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This review provides insights into the distribution and impact of oestrogens and xeno-oestrogens in the aquatic environment and highlights some significant knowledge gaps in our understanding of endocrine disrupting chemicals. Key areas of uncertainty in the assessment of risk include the role of estuarine sediments in mediating the fate and bioavailability of environmental (xeno)oestrogens (notably their transfer to benthic organisms and estuarine food chains), together with evidence for endocrine disruption in invertebrate populations.Emphasis is placed on using published information to interpret the behaviour and effects of a small number of ‘model compounds’ thought to contribute to oestrogenic effects in nature; namely, the natural steroid 17β-oestradiol (E2) and the synthetic hormone 17α-ethinyloestradiol (EE2), together with the alkylphenols octyl- and nonyl-phenol (OP, NP) as oestrogen mimics. Individual sections of the review are devoted to sources and concentrations of (xeno)oestrogens in waterways, sediment partitioning and persistence, bioaccumulation rates and routes, assays and biomarkers of oestrogenicity, and, finally, a synopsis of reproductive and ecological effects in aquatic species.
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Castro, L. Filipe C., und Miguel M. Santos. „To Bind or Not To Bind: The Taxonomic Scope of Nuclear Receptor Mediated Endocrine Disruption in Invertebrate Phyla“. Environmental Science & Technology 48, Nr. 10 (08.05.2014): 5361–63. http://dx.doi.org/10.1021/es501697b.
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Oehlmann, J., und U. Schulte-Oehlmann. „Endocrine disruption in invertebrates“. Pure and Applied Chemistry 75, Nr. 11-12 (01.01.2003): 2207–18. http://dx.doi.org/10.1351/pac200375112207.
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Recent reports have shown that a number of xenobiotics in the environment are capable of interfering with the normal endocrine function in a variety of animals. The overwhelming majority of the studies on the effects of hormone-mimetic industrial chemicals were focused on findings in vertebrates. More detailed information about the effects on and mechanisms of action in invertebrates has only been obtained from a few cases, although invertebrates represent more than 95 % of the known species in the animal kingdom and are extremely important with regard to ecosystem structure and function. The limited number of examples for endocrine disruption (ED) in invertebrates is partially due to the fact that their hormonal systems are rather poorly understood in comparison with vertebrates. Deleterious endocrine changes following an exposure to certain compounds may easily be missed or simply be unmeasurable at present, even though a number of studies show that endocrine disruption has probably occurred. The well-documented case studies of tributyltin effects in mollusks and of insect growth regulators, the latter as purposely synthesized endocrine disruptors, are explained to support this view. According to our present knowledge, there is no reason to suppose that such far-reaching changes are in any sense unique. The additional existing evidence for ED in invertebrates from laboratory and field studies are summarized as an update and amendment of the EDIETA report from 1998. Finally, conclusions about the scale and implications of the observed effects are drawn and further research needs are defined.
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Ziani, Khaled, Corina-Bianca Ioniță-Mîndrican, Magdalena Mititelu, Sorinel Marius Neacșu, Carolina Negrei, Elena Moroșan, Doina Drăgănescu und Olivia-Teodora Preda. „Microplastics: A Real Global Threat for Environment and Food Safety: A State of the Art Review“. Nutrients 15, Nr. 3 (25.01.2023): 617. http://dx.doi.org/10.3390/nu15030617.
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Microplastics are small plastic particles that come from the degradation of plastics, ubiquitous in nature and therefore affect both wildlife and humans. They have been detected in many marine species, but also in drinking water and in numerous foods, such as salt, honey and marine organisms. Exposure to microplastics can also occur through inhaled air. Data from animal studies have shown that once absorbed, plastic micro- and nanoparticles can distribute to the liver, spleen, heart, lungs, thymus, reproductive organs, kidneys and even the brain (crosses the blood–brain barrier). In addition, microplastics are transport operators of persistent organic pollutants or heavy metals from invertebrate organisms to other higher trophic levels. After ingestion, the additives and monomers in their composition can interfere with important biological processes in the human body and can cause disruption of the endocrine, immune system; can have a negative impact on mobility, reproduction and development; and can cause carcinogenesis. The pandemic caused by COVID-19 has affected not only human health and national economies but also the environment, due to the large volume of waste in the form of discarded personal protective equipment. The remarkable increase in global use of face masks, which mainly contain polypropylene, and poor waste management have led to worsening microplastic pollution, and the long-term consequences can be extremely devastating if urgent action is not taken.
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Lewis, S. E., A. Yokofich, M. Mohr, C. Kurth, R. Giuliani und M. G. Baldridge. „Exposure to bisphenol A modulates hormone concentrations in Gammarus pseudolimnaeus“. Canadian Journal of Zoology 90, Nr. 12 (Dezember 2012): 1414–21. http://dx.doi.org/10.1139/cjz-2012-0178.
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Bisphenol A (BPA) is an endocrine-disrupting compound that can enter aquatic systems through landfill leachate or wastewater effluent. Although impacts of BPA on vertebrates are well documented, its effects on invertebrates are less clear. Amphipods such as Gammarus pseudolimnaeus Bousfield, 1958 are often prevalent invertebrates in freshwater ecosystems and can provide a powerful invertebrate model system to investigate the endocrine-disruptive capabilities of BPA. However, techniques to assay hormone concentrations in amphipods, especially vertebrate-like steroid sex hormones, are not widespread. In this study, we (i) quantified estrogen concentrations in juveniles and in adult female amphipods; (ii) quantified testosterone concentrations in juveniles and in adult male amphipods; and (iii) delineated changes to estrogen and testosterone concentrations of adults and juveniles following a 9-day exposure to BPA at four levels: 0 (control), 10, 50, and 100 µg/L BPA. Tissue extracts from homogenized samples were analyzed for estrogen or testosterone concentrations via radioimmunoassay for each reproductive class of amphipod. Low concentrations of BPA significantly increased estrogen concentrations in adult females and in juveniles. Moderate and high concentrations of BPA significantly increased testosterone concentrations in adult males, and low and moderate concentrations of BPA significantly increased testosterone concentrations of juveniles.
Dissertationen zum Thema "Invertebrate Endocrine Disruption"
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MIGLIOLI, ANGELICA. „Pathways of Endocrine Disruption in the larval development of the mediterranean mussel Mytilus galloprovincialis“. Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1062149.
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Endocrine Disruptors (EDCs) are a class of anthropogenic environmental contaminants that affect the endocrine systems of living organisms. The lack of knowledge of endocrine systems prevents the understanding of the effect of PEs in invertebrates. Accordingly, this thesis aims to address the issue of endocrine disruption in marine invertebrates by exploiting the larval development of the Mediterranean mussel Mytilus galloprovincialis. By applying the logic of the Adverse Outcome Pathway-AOP, the work in this thesis attempted to characterize the mechanism of action of the model EDCs BPA, TBBPA and TBT in mussel larvae and to identify plausible neuroendocrine pathways by which they induce their deleterious biological effect. The neuroendocrine elements regulating the biogenesis of the larval shell have been characterized and the morphogenetic process established as sensitive to neuroendocrine disruption. Plausible neuroendocrine AOPs that could be linked to the biological effects of the model EDCs have been identified. In addition, the possible AOP of TBT has established a plausible relationship between nuclear receptor signaling and the neuroendocrine system of mussel larvae. The results of this thesis represent essential evidence that will help and advance the current understanding of endocrine disruption mechanisms in invertebrate organisms.
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Sambles, Christine. „Derivation of the molecular basis of endocrine disruption in aquatic invertebrates“. Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54659/.
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Endocrine disrupting chemicals (EDCs) have attracted worldwide media attention due to their feminisation effects on aquatic organisms. Studies on the environmental effects of these compounds have become increasingly important due to fears of increased infertility and their influence on the dynamics of an ecological niche. The benthic invertebrate
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Bjørnstad, Anne. „Proteomics and ecotoxicoldgy : marine invertebrates and endocrine disrupting chemicals“. Thesis, University of Plymouth, 2008. http://hdl.handle.net/10026.1/1067.
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The key problem faced by environmental scientists is to predictand recognize the damaging effects of chemical pollutants on natural biota. The aim of this thesis was to evaluate the potential for proteomics in ecotoxicology and environmental risk assessment (ERA), with the hypothesis that proteomic technologies (i.e. ProteinChip technology in combination with SELDI TOF MS) could be a useftil supplement to existing methods of environmental assessment, by providing a sensitive, non-invasive, rapid multi-endpoint assessment of effects of anthropogenic chemicals on organism in vivo. Three invertebrate species, Mytilus edulis, Hyas araneus and Strongylocentrotus droebachiensis was exposed to natural and anthropogenic chemicals in laboratory and field studies. Results revealed that proteomics was a sensitive endpoint, as all exposure regimes significantly affected protein expression. It was shown that plasma protein expression profiles contained information that was compound, dose, site, species and gender-specific. Regarding the latter; male and female organisms responded differently to all exposures both quantitatively (e.g. in terms of number of affected protein species) and qualitatively (e.g. in terms of tj^e of affected protein species). Furthermore, genders have shown opposite responses following the same exposure regime. Equally, species-specific responses were observed. Moreover, exposing organisms to graded levels of contamination under controlled laboratory conditions and in the field revealed that different subsets of proteomes were affected at different levels of exposure. This finding represents an opportunity for appljdng proteomics for both prognostic (e.g. early warning of potential adverse effects or assessment of recovery) and diagnostic purposes. Moreover, those protein features that were changed by all exposure concentrations showed complex dose-response relationships, including both linear and various types of biphasic response-curves. In summary, results from the present study indicate that proteomics have the potential to be a useftil tool in ERA. For example, identification of key molecules could elucidate mechanism of action related to mixture effects, gender and species-specific susceptibility to environmental pollutants as well as dose-response relationships at low doses. Furthermore, key proteins (i.e. putative biomarkers) could, be purified and coupled to e.g. a biosensor for automated monitoring.
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Miguel, Mariana. „Efeito do hormônio sintético 17α-etinilestradiol no invertebrado aquático Daphnia magna (Crustacea, Cladocera)“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/18/18139/tde-31032016-101847/.
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Muitas substâncias descartadas no meio ambiente não são totalmente degradadas, podendo assim persistir no ambiente. Diversos compostos são continuamente introduzidos no ambiente podendo afetar a biota e inclusive o homem. Os fármacos são alguns desses compostos que depois de descartados podem chegar nos corpos de águas naturais, e dentre eles merecem especial atenção os hormônios sintéticos utilizados em larga escala por mulheres em todo o mundo, na forma de contraceptivos orais. O hormônio sintético 17α-etinilestradiol é um micropoluente no ambiente aquático, que pode causar distúrbios na reprodução de diversos organismos atuando como um desregulador endócrino. O presente estudo teve como objetivo principal analisar o efeito do hormônio sintético 17α-etinilestradiol sobre o cladócero Daphnia magna, por meio de testes ecotoxicológicos. Testes de toxicidade crônica foram realizados em duas gerações consecutivas deste microcrustáceo (F0 e F1). Para os testes utilizaram-se neonatas com menos de 24 horas de idade, 6 concentrações do hormônio e dois controles. Foram estabelecidas 10 réplicas com 1 indivíduo por réplica. O ensaio foi realizado em incubadora com temperatura de 25 ± 1°C e fotoperíodo de 12h claro:12h escuro, com duração de 11 (F0) e 13 dias (F1), com término coincidindo com o nascimento das neonatas da terceira ninhada no controle. Os resultados evidenciaram que a exposição ao hormônio diminuiu a fecundidade de Daphnia magna nas quatro maiores concentrações de etinilestradiol na F0 e na concentração de 1000 μg L-1 da F1, revelando maior resistência ao contaminante na segunda geração. Na maior concentração do composto, o tempo para a produção das duas primeiras ninhadas foi maior na geração F1, quando comparada ao controle. Na concentração de 250 μg L-1 verificou-se a ocorrência de um indivíduo intersexo, apresentando tanto características de macho como de fêmea. Os resultados deste estudo evidenciaram que o 17α-etinilestradiol afeta a reprodução de Daphnia magna, e que também pode afetar a reprodução de diferentes invertebrados aquáticos, o que, a longo prazo pode causar danos às populações e comunidades aquáticas, diminuindo as populações e podendo até extingui-las eventualmente.Many substances are discarded in the environment and not completely degraded, thus persisting in the environment. Some of these are continuously introduced in the environment, affecting the biota, including man. Pharmaceutical drugs are some of these compounds that after discarded can occur in natural water bodies and among them the synthetic hormones deserve special attention for being used in large scale by women world widely, as oral contraceptives. The synthetic hormone 17α-ethinyl estradiol is therefore a micropoluent in the aquatic environment, i. e. found in low concentrations that can cause deleterious effects in the reproduction of many organisms, acting as an endocrine disruptor. The present study had as main objective to analyze the effect of the synthetic estrogen 17α-ethinyl estradiol on the cladoceran Daphnia magna, by carrying out ecotoxicological tests. Chronic toxicity tests were performed on two consecutive generations of this microcrustacean (F0 and F1). In order to perform the tests, neonates aged less than 24 hours, 6 hormones concentrations and two types of controls were used. Ten replicates were established with one individual each. The test was performed in a growth chamber at the constant temperature of 25 ± 1°C and 12 h light:12 h dark photoperiod, had the duration of 11 and 13 days for the F1 and F0 generations, respectively, coinciding with the birth of the third brood in the control. The results evidenced that the exposition to the hormone decreased D. magna fecundity in the four highest of ethinyl estradiol in F0, and in the concentration 1000 μg L-1 for the F1, indicating resistance increase in the second generation. In the highest concentration of this compound the time for the production of the first two broods were higher in the F1 generation as compared with the controls. In the hormone concentration of 250 μg L-1 the occurrence of an intersex individual was verified, simultaneously presenting characteristics of male and female. The results of this study evidenced the 17α-ethinyl estradiol affect the reproduction of Daphnia magna, and can affect the reproduction of other aquatic invertebrates that at long term can cause damages to aquatic populations and communities by diminishing populations and eventually leading them to the extinction.
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Jubeaux, Guilaume. „Développement de la mesure de la vitellogénine chez les invertébrés & utilisation de marqueurs de la perturbation endocrinienne chez le crustacé amphipode gammarus fossarum“. Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10111/document.
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Parmi les substances polluantes, les perturbateurs endocriniens (PE) sont au coeur des préoccupations scientifiques en raison du risque de ces composés pour l'environnement, et en particulier les écosystèmes aquatiques. L'étude de la disponibilité et de l'impact des PE sur les vertébrés aquatiques, en particulier les poissons, a fait l'objet de nombreux projets et publications. Ces travaux ont conduit au développement d'outils de diagnostic pouvant être utilisés in situ, comme par exemple l'induction de la vitellogénine (Vg) chez les mâles, l'inhibition de la croissance ovarienne et testiculaire, le retard dans la maturité sexuelle, la présence d'individus intersexués et les concentrations anormales en hormones stéroïdiennes. En revanche, peu d'attention a été portée aux invertébrés qui représentent pourtant plus de 95 % des espèces animales et jouent un rôle essentiel dans le fonctionnement et la santé des écosystèmes aquatiques. Par conséquent, il en résulte un manque d'outils spécifiques de la perturbation endocrinienne chez ces espèces. Dans ce contexte, le travail proposé se focalise tout d'abord sur l'intérêt et la pertinence de la spectrométrie de masse (LC-MS/MS) pour développer ou transférer entre espèces une méthode de mesure de la Vg chez les invertébrés, incluant les crustacés, les mollusques et les insectes. Ensuite, ce travail s'est intéressé à un crustacé amphipode modèle (Gammarus fossarum) et avait pour objectifs (1) de développer le biomarqueur Vg, via la validation de son rôle fonctionnel dans la reproduction (vitellogenèse, embryogenèse et différences inter-sexe), de sa sensibilité à des composés modèles et jusqu'à son utilisation dans le cadre d'études de terrain à l'aide d'organismes encagés et (2) de développer l'utilisation d'une approche chez la femelle permettant de caractériser le potentiel PE de composés et des systèmes aquatiques, à partir de l'étude de marqueurs individuelsAmong pollutants, endocrine disruptors (ED) are in central scientific preoccupation because of the risks of these compounds to the environment, in particular for aquatic ecosystems. The availability and impact study of ED on aquatic vertebrates, in particular fishes, was the subject of many projects and papers. These studies led to the development of diagnostic tools, such as vitellogenin (Vg) induction in male organisms, inhibition of ovarian and testicular growth, delayed sexual maturity, presence of intersex individuals and abnormal concentrations of steroid hormones. However, little attention was paid to invertebrates which account for more than 95% of animal species and play an essential role in functioning and health of aquatic ecosystems. Therefore, the result is a lack of specific tools for endocrine disruption assessment in these species. In this context, the proposed work focuses first on the interest and relevance of mass spectrometry (LC-MS/MS) to develop and to transfer among species a method for measuring Vg in invertebrates species, including crustaceans, molluscs and insects. Then, this work has focused on a model amphipod crustacean (Gammarus fossarum) and aims were (1) to develop the Vg biomarker, through the validation of its functional role in reproduction (vitellogenesis, embryogenesis and inter-sex differences), its sensitivity towards model compounds and to its use in field monitoring, using caged organisms and (2) develop a biotest in the female to assess the ED risk of chemical compounds and aquatic systems, by studying and measuring individual markers
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Vogeler, Susanne. „Nuclear receptors in the Pacific oyster, Crassostrea gigas, as screening tool for determining response to environmental contaminants“. Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/23626.
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Marine environments are under constant pressure from anthropogenic pollution. Chemical pollutants are introduced into the aquatic environment through waste disposal, sewage, land runoff and environmental exploitation (harbours, fisheries, tourism) leading to disastrous effects on the marine wildlife. Developmental malformations, reproduction failure including sex changes and high death rates are commonly observed in aquatic animal populations around the world. Unfortunately, the underlying molecular mechanisms of these pollution effects, in particular for marine invertebrate species, are often unknown. One proposed mechanism through which environmental pollution affects wildlife, is the disruption of nuclear receptors (NRs), ligand-binding transcription factors in animals. Environmental pollutants can directly interact with nuclear receptors, inducing incorrect signals for gene expression and subsequently disrupt developmental and physiological processes. Elucidation of the exact mechanism in invertebrates, however, is sparse due to limited understanding of invertebrate endocrinology and molecular regulatory mechanisms. Here, I have investigated the presence, expression and function of NRs in the Pacific oyster, Crassostrea gigas, and explored their interrelation with known environmental pollutants. Using a suite of molecular techniques and bioinformatics tools I demonstrate that the Pacific oyster possesses a large variety of NR homologs (43 NRs), which display individual expression profiles during embryo/larval development and supposedly fulfil distinct functions in developmental and physiological processes. Functional studies on a small subset of oyster NRs provided evidence for their ability to regulate gene expression, including interactions with DNA, other NRs or small molecules (ligand-binding). Oyster receptors also show a high likeliness to be disrupted by environmental pollutants. Computational docking showed that the retinoid X receptor ortholog, CgRXR, is able to bind and be activated by 9-cis retinoic acid and by the well-known environmental contaminant tributyltin. A potential interaction between tributyltin and the peroxisome proliferator-activated receptor ortholog CgPPAR has also been found. In addition, exposure of oyster embryos to retinoic acids and tributyltin resulted in shell deformations and developmental failure. In contrast, computer modelling of another putative target for pollutants, the retinoic acid receptor ortholog CgRAR, did not indicate interactions with common retinoic acids, supporting a recently developed theory of loss of retinoid binding in molluscan RARs. Sequence analyses revealed six residues in the receptor sequence, which prevent the successful interaction with retinoid ligands. In conclusion, this investigative work aids the understanding of fundamental processes in invertebrates, such as gene expression and endocrinology, as well as further understanding and prediction of effects of environmental pollutants on marine invertebrates.
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André, Ana Isabel Duarte. „Impact of endocrine disrupting chemicals in nuclear receptor signaling in marine organisms: invertebrate insights“. Doctoral thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/101366.
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André, Ana Isabel Duarte. „Impact of endocrine disrupting chemicals in nuclear receptor signaling in marine organisms: invertebrate insights“. Tese, 2016. https://repositorio-aberto.up.pt/handle/10216/101366.
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Borysko, Larissa. „Effects of the synthetic hormone 17 α-ethynylestradiol on the reproduction and early life histories of the estuarine gastropods Nassarius burchardi and Nassarius jonasii / Larissa Borysko“. Thesis, 2008. http://handle.uws.edu.au:8081/1959.7/506632.
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Over the past ten to fifteen years there has been a growing concern that some synthetic and naturally occurring compounds may be altering the normal function of endocrine systems in humans and wildlife. These compounds, termed Endocrine Disrupting Compounds (EDCs), have been found in many aquatic environments where they come into contact with vertebrate and invertebrate organisms. To date, natural and synthetic estrogens and xeno-estrogens have received the most attention and caused the greatest concern because they mimic the vertebrate hormone estrogen. The synthetic estrogenic hormone 17α- ethynylestradiol (EE2), a component of the birth control pill and hormone replacement therapies, has received increased scrutiny because it has been detected in aquatic environments worldwide. It has been correlated with observations of reproductive dysfunction and morphological and histological abnormalities in several studies of fish, however, little is known about the effects this compound may have on invertebrates. While internationally research has slowly begun to fill gaps in our knowledge and understanding of the effects of EDCs on invertebrate organisms, studies in Australia, with its large number of endemic species remain in their infancy. There is an urgent need to develop toxicity testing with EDCs to measure the response and determine the level of impact of these compounds in aquatic habitats in Australia. Part of the reason for the paucity of studies in Australia is the lack of general ecological knowledge of many invertebrates, especially those living in estuarine areas. These organisms are potentially vulnerable because they inhabit environments that receive waters from areas upstream containing pollutants such as EDCs.
Bücher zum Thema "Invertebrate Endocrine Disruption"
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1950-, DeFur Peter L., und International SETAC Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (1998 : Noordwijkerhout, Netherlands), Hrsg. Endocrine disruption in invertebrates: Endocrinology, testing, and assessment. Pensacola, FL: SETAC Press, 1999.
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International Setac Workshop on Endocrine Disruption in Invertebrates (Corporate Author) und Peter L. Defur (Editor), Hrsg. Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (Setac Technical Publications Series). Society of Environmental Toxicology & Chemist, 1999.
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Zou, E. „Aquatic Invertebrate Endocrine Disruption“. In Encyclopedia of Animal Behavior, 112–23. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-08-045337-8.00266-7.
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Zou, Enmin. „Aquatic Invertebrate Endocrine Disruption“. In Encyclopedia of Animal Behavior, 470–82. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-809633-8.01045-1.
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Frame, Lynn, und Richard L. Dickerson. „Fish and Wildlife as Sentinels of Environmental Contamination“. In Endocrine Disruption, 202–22. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195137491.003.0010.
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Abstract Fish, wildlife, invertebrates, and microorganisms have been widely touted as sentinels for the health of the environment and thus as protectors of human health (Sheffield et al., 1998; Guillette, 2000; Fox, 2001 ). How sentinel systems can help us detect exposures that may result in adverse effects including endocrine disruption was the subject of a workshop sponsored by the U.S. Army Center for Environmental Health Research, the National Center for Environmental Assessment of the U.S. EPA, and the Agency for Toxic Substances and Disease Registry (van der Schalie et al., 1999).
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Oetken, Matthias, Jean Bachmann, Ulrike Schulte-Oehlmann und Jörg Oehlmann. „Evidence for Endocrine Disruption in Invertebrates“. In International Review of Cytology, 1–44. Elsevier, 2004. http://dx.doi.org/10.1016/s0074-7696(04)36001-8.
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Leung, Kenneth, James Wheeler, David Morritt und Mark Crane. „Endocrine Disruption in Fishes and Invertebrates“. In Environmental and Ecological Risk Assessment. CRC Press, 2001. http://dx.doi.org/10.1201/9781420032451.ch8.
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„Endocrine Disruption in Fishes and Invertebrates: Issues for Saltwater Ecological Risk Assessment“. In Coastal and Estuarine Risk Assessment, 205–32. CRC Press, 2001. http://dx.doi.org/10.1201/9781420032451-12.
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„PAH Metabolites in Fish and Invertebrates: Analysis and Endocrine Disruptive Potential“. In Petrogenic Polycyclic Aromatic Hydrocarbons in the Aquatic Environment: Analysis, Synthesis, Toxicity and Environmental Impact, herausgegeben von Denise Fernandes, Anna Marqueno, Cinta Porte und Montserrat Sole, 111–34. BENTHAM SCIENCE PUBLISHERS, 2017. http://dx.doi.org/10.2174/9781681084275117010008.
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Afshan, Anjum, Md Niamat Ali und Farooz Ahmed Bhat. „Environmental Phthalate Exposure in Relation to Reproduction Outcomes and Health Endpoints“. In Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution, 340–69. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-5225-9452-9.ch017.
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Environmental pollutants, like xenobiotic substances released as byproducts of anthropogenic actions, naturally lead to pollution of the environment. They negatively affect the environment through unfavorable impacts on growth, development, and reproduction of organisms including humans. One of the outstanding examples of xenobiotics is endocrine disrupting compounds (EDCs) such as phthalate esters (PEs), which have the efficacy to disturb numerous biological systems including the invertebrate, reptilian, avian, aquatic, and also the mammalian systems. Phthalates are family of xenobiotic hazardous compounds amalgamating in plastics to intensify their plasticity, flexibility, longevity, versatility, and durability. Ignoring the rising issue on the hazardous nature of various phthalates and their metabolites, ruthless usage of phthalates as plasticizer in plastics and as additives in innumerable consumer products continues due to their low eminent properties, their cost-effectiveness, and lack of suitable alternatives. Globally epidemiological human studies showed various phthalates and their metabolites ingested passively by man from the general environment, foods, drinks, breathing air, and routine household products cause various dysfunctions. This comprehensive chapter on the hazards of phthalates would benefit the general population, academia, scientists, clinicians, environmentalists, and law or policymakers to decide upon whether usage of phthalates to be continued swiftly without sufficient deceleration or regulated by law or to be phased out from earth forever.
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Afshan, Anjum, Md Niamat Ali und Farooz Ahmed Bhat. „Environmental Phthalate Exposure in Relation to Reproduction Outcomes and Health Endpoints“. In Research Anthology on Advancements in Women's Health and Reproductive Rights, 576–605. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-6299-7.ch031.
Der volle Inhalt der QuelleAnnotation:
Environmental pollutants, like xenobiotic substances released as byproducts of anthropogenic actions, naturally lead to pollution of the environment. They negatively affect the environment through unfavorable impacts on growth, development, and reproduction of organisms including humans. One of the outstanding examples of xenobiotics is endocrine disrupting compounds (EDCs) such as phthalate esters (PEs), which have the efficacy to disturb numerous biological systems including the invertebrate, reptilian, avian, aquatic, and also the mammalian systems. Phthalates are family of xenobiotic hazardous compounds amalgamating in plastics to intensify their plasticity, flexibility, longevity, versatility, and durability. Ignoring the rising issue on the hazardous nature of various phthalates and their metabolites, ruthless usage of phthalates as plasticizer in plastics and as additives in innumerable consumer products continues due to their low eminent properties, their cost-effectiveness, and lack of suitable alternatives. Globally epidemiological human studies showed various phthalates and their metabolites ingested passively by man from the general environment, foods, drinks, breathing air, and routine household products cause various dysfunctions. This comprehensive chapter on the hazards of phthalates would benefit the general population, academia, scientists, clinicians, environmentalists, and law or policymakers to decide upon whether usage of phthalates to be continued swiftly without sufficient deceleration or regulated by law or to be phased out from earth forever.