Zeitschriftenartikel: „Interaction of Dendrimers and Liposomes“

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Efimova, Аnna А., Svetlana A. Sorokina, Kseniya S. Trosheva, Alexander A. Yaroslavov und Zinaida B. Shifrina. „Complexes of Cationic Pyridylphenylene Dendrimers with Anionic Liposomes: The Role of Dendrimer Composition in Membrane Structural Changes“. International Journal of Molecular Sciences 24, Nr. 3 (22.01.2023): 2225. http://dx.doi.org/10.3390/ijms24032225.

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In the last decades, dendrimers have received attention in biomedicine that requires detailed study on the mechanism of their interaction with cell membranes. In this article, we report on the role of dendrimer structure in their interaction with liposomes. Here, the interactions between cationic pyridylphenylene dendrimers of the first, second, and third generations with mixed or completely charged pyridyl periphery (D16+, D215+, D229+, and D350+) with cholesterol-containing (CL/Chol/DOPC) anionic liposomes were investigated by microelectrophoresis, dynamic light scattering, fluorescence spectroscopy, and conductometry. It was found that the architecture of the dendrimer, namely the generation, the amount of charged pyridynium groups, the hydrophobic phenylene units, and the rigidity of the spatial structure, determined the special features of the dendrimer–liposome interactions. The binding of D350+ and D229+ with almost fully charged peripheries to liposomes was due to electrostatic forces: the dendrimer molecules could be removed from the liposomal surfaces by NaCl addition. D350+ and D229+ did not display a disruptive effect toward membranes, did not penetrate into the hydrophobic lipid bilayer, and were able to migrate between liposomes. For D215+, a dendrimer with a mixed periphery, hydrophobic interactions of phenylene units with the hydrocarbon tails of lipids were observed, along with electrostatic complexation with liposomes. As a result, defects were formed in the bilayer, which led to irreversible interactions with lipid membranes wherein there was no migration of D215+ between liposomes. A first-generation dendrimer, D16+, which was characterized by small size, a high degree of hydrophobicity, and a rigid structure, when interacting with liposomes caused significant destruction of liposomal membranes. Evidently, this interaction was irreversible: the addition of salt did not lead to the dissociation of the complex.

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Trosheva, K. S., S. A. Sorokina und A. A. Efimova. „Interaction Between Anionic Liposomes and Cationic Pyridylphenylene Dendrimers“. Moscow University Chemistry Bulletin 75, Nr. 2 (März 2020): 101–5. http://dx.doi.org/10.3103/s0027131420020169.

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Carloni, Riccardo, Natalia Sanz del Olmo, Paula Ortega, Alberto Fattori, Rafael Gómez, Maria Francesca Ottaviani, Sandra García-Gallego, Michela Cangiotti und F. Javier de la Mata. „Exploring the Interactions of Ruthenium (II) Carbosilane Metallodendrimers and Precursors with Model Cell Membranes through a Dual Spin-Label Spin-Probe Technique Using EPR“. Biomolecules 9, Nr. 10 (27.09.2019): 540. http://dx.doi.org/10.3390/biom9100540.

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Dendrimers exhibit unique interactions with cell membranes, arising from their nanometric size and high surface area. To a great extent, these interactions define their biological activity and can be reported in situ by spin-labelling techniques. Schiff-base carbosilane ruthenium (II) metallodendrimers are promising antitumor agents with a mechanism of action yet to explore. In order to study their in situ interactions with model cell membranes occurring at a molecular level, namely cetyltrimethylammonium bromide micelles (CTAB) and lecithin liposomes (LEC), electron paramagnetic resonance (EPR) was selected. Both a spin probe, 4-(N,N-dimethyl-N-dodecyl)ammonium-2,2,6,6-tetramethylpiperidine-1-oxyl bromide (CAT12), able to enter the model membranes, and a spin label, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) covalently attached at newly synthesized heterofunctional dendrimers, were used to provide complementary information on the dendrimer–membrane interactions. The computer-aided EPR analysis demonstrated a good agreement between the results obtained for the spin probe and spin label experiments. Both points of view suggested the partial insertion of the dendrimer surface groups into the surfactant aggregates, mainly CTAB micelles, and the occurrence of both polar and hydrophobic interactions, while dendrimer–LEC interactions involved more polar interactions between surface groups. We found out that subtle changes in the dendrimer structure greatly modified their interacting abilities and, subsequently, their anticancer activity.

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Dragomanova, Stela, und Velichka Andonova. „Adamantane-containing drug delivery systems“. Pharmacia 70, Nr. 4 (11.10.2023): 1057–66. http://dx.doi.org/10.3897/pharmacia.70.e111593.

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Adamantane is a weakly functional hydrocarbon widely used to develop new drug molecules to improve their pharmacokinetic and pharmacodynamic parameters. The compound has an affinity for the lipid bilayer of liposomes, enabling its application in targeted drug delivery and surface recognition of target structures. This review presents the available data on developed liposomes, cyclodextrin complexes, and adamantane-based dendrimers. Adamantane has been used in two ways – as a building block to which various functional groups are covalently attached (adamantane-based dendrimers) or as a part of self-aggregating supramolecular systems, where it is incorporated based on its lipophilicity (liposomes) and strong interaction with the host molecule (cyclodextrins). Adamantane represents a suitable structural basis for the development of drug delivery systems. The study of adamantane derivatives is a current topic in designing safe and selective drug delivery systems and molecular carriers.

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Purohit, Gaurang, Thiagarajan Sakthivel und Alexander T. Florence. „Interaction of cationic partial dendrimers with charged and neutral liposomes“. International Journal of Pharmaceutics 214, Nr. 1-2 (Februar 2001): 71–76. http://dx.doi.org/10.1016/s0378-5173(00)00635-9.

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Wrobel, Dominika, Maksim Ionov, Konstantinos Gardikis, Costas Demetzos, Jean-Pierre Majoral, Bartlomiej Palecz, Barbara Klajnert und Maria Bryszewska. „Interactions of phosphorus-containing dendrimers with liposomes“. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1811, Nr. 3 (März 2011): 221–26. http://dx.doi.org/10.1016/j.bbalip.2010.11.007.

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Bacha, Katia, Catherine Chemotti, Jean-Claude Monboisse, Anthony Robert, Aurélien L. Furlan, Willy Smeralda, Christian Damblon et al. „Encapsulation of Vitamin C by Glycerol-Derived Dendrimers, Their Interaction with Biomimetic Models of Stratum corneum and Their Cytotoxicity“. Molecules 27, Nr. 22 (18.11.2022): 8022. http://dx.doi.org/10.3390/molecules27228022.

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Vitamin C is one of the most sensitive cosmetic active ingredients. To avoid its degradation, its encapsulation into biobased carriers such as dendrimers is one alternative of interest. In this work, we wanted to evaluate the potential of two biobased glycerodendrimer families (GlyceroDendrimers-Poly(AmidoAmine) (GD-PAMAMs) or GlyceroDendrimers-Poly(Propylene Imine) (GD-PPIs)) as a vitamin C carrier for topical application. The higher encapsulation capacity of GD-PAMAM-3 compared to commercial PAMAM-3 and different GD-PPIs, and its absence of cytotoxicity towards dermal cells, make it a good candidate. Investigation of its mechanism of action was done by using two kinds of biomimetic models of stratum corneum (SC), lipid monolayers and liposomes. GD-PAMAM-3 and VitC@GD-PAMAM-3 (GD-PAMAM-3 with encapsulated vitamin C) can both interact with the lipid representatives of the SC lipid matrix, whichever pH is considered. However, only pH 5.0 is suggested to be favorable to release vitamin C into the SC matrix. Their binding to SC-biomimetic liposomes revealed only a slight effect on membrane permeability in accordance with the absence of cytotoxicity but an increase in membrane rigidity, suggesting a reinforcement of the SC barrier property. Globally, our results suggest that the dendrimer GD-PAMAM-3 could be an efficient carrier for cosmetic applications.

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Falanga, Annarita, Rossella Tarallo, Thomas Carberry, Massimiliano Galdiero, Marcus Weck und Stefania Galdiero. „Elucidation of the Interaction Mechanism with Liposomes of gH625-Peptide Functionalized Dendrimers“. PLoS ONE 9, Nr. 11 (25.11.2014): e112128. http://dx.doi.org/10.1371/journal.pone.0112128.

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Pantos, Alexandros, Dimitris Tsiourvas, George Nounesis und Constantinos M. Paleos. „Interaction of Functional Dendrimers with Multilamellar Liposomes: Design of a Model System for Studying Drug Delivery“. Langmuir 21, Nr. 16 (August 2005): 7483–90. http://dx.doi.org/10.1021/la0510331.

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Brhane, Yonas, Tesfaye Gabriel, Tigist Adane, Yemisrach Negash, Henok Mulugeta und Mulugeta Ayele. „Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis“. International Journal of Pharmaceutical Sciences and Nanotechnology 12, Nr. 3 (31.05.2019): 4524–30. http://dx.doi.org/10.37285/ijpsn.2019.12.3.2.

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Tuberculosis (TB) is a contagious infectious illness caused by species having a place with the Mycobacterium tuberculosis complex. The clinical management of tuberculosis still remains a difficult task. Treatment of TB with anti-tubercular drugs becomes the only option available. Hence, the goals of treatment are ensure cure without relapse, prevent death, impede transmission, and prevent emergence of drug resistant strains. This review describes the latest developments and innovative drug delivery strategies for treatment of TB in order to improve the therapeutic efficacy and reduce toxic effect of anti-tubercular agents and enhance patient compliance with concomitant decrease in drug interaction. Among different novel drug delivery systems Niosomes, Liposomes, Dendrimers, Cyclodextrins, Microencapsulation, Alginates and Hydrogels have been described as new drug delivery strategies of anti-tubercular agents.

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Vassallo, Antonio, Maria Francesca Silletti, Immacolata Faraone und Luigi Milella. „Nanoparticulate Antibiotic Systems as Antibacterial Agents and Antibiotic Delivery Platforms to Fight Infections“. Journal of Nanomaterials 2020 (12.09.2020): 1–31. http://dx.doi.org/10.1155/2020/6905631.

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Today’s human society, product of decades of progress in all fields of knowledge, would have been unimaginable without the discovery of antibiotics and more generally of antimicrobials. However, from the beginning, the scientific community was aware that microorganisms through various strategies were able to hinder and render vain antibiotic action. Common examples are the phenomena of persistence, tolerance, and resistance, up to the creation of the feared bacterial biofilms. Antibiotics are a precious but equally labile resource that must be preserved but at the same time reinforced to safeguard their effectiveness. Nanoparticulate systems such as nanobactericides, with their inherent antibacterial activity, and nanocarriers, which operate as drug delivery systems for conventional antibiotics, are innovative therapies made available by nanotechnology. Inorganic nanoparticles are effective both as nanobactericides (AgNPs, ZnONPs, and TiO2NPs) and as nanocarriers (AgNPs, AuNPs, ZnONPs, and TiO2NPs) against sensitive and multi-drug-resistant bacterial strains. Liposomes are among the most studied and flexible antibiotic delivery platforms: conventional liposomes allow passive targeting at the mononuclear phagocytic system (MPS); “stealth” liposomes prevent macrophage uptake so as to eradicate infections in tissues and organs outside MPS; thanks to their positive charge, cationic liposomes interact preferentially with bacterial and biofilm surfaces, acting as innate antibacterials as well as drug delivery systems (DDS); fusogenic liposomes have fluid bilayers that promote fusion with microbial membranes; and finally, ligand-targeted liposomes provide active targeting at infection sites. Dendrimers are among the most recent and attractive nanoparticulate systems, thanks to their multibranched nanoarchitecture, which equipped them with multiple active sites for loading antibiotics and also interacting with bacteria. Finally, nanoantibiotics represent a new hopeful generation of antibiotic candidates capable of increasing or even restoring the clinical efficacy of “old” antibiotics rendered useless by the resistance phenomena.

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Imran, Mohammad, Saurav Kumar Jha, Nazeer Hasan, Areeba Insaf, Jitendra Shrestha, Jesus Shrestha, Hari Prasad Devkota et al. „Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems“. Pharmaceutics 14, Nr. 3 (08.03.2022): 586. http://dx.doi.org/10.3390/pharmaceutics14030586.

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Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists’ interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. This review article comprises the specific mechanism of antibiotic resistance development in bacteria. In addition, the manuscript incorporated the advanced nanotechnological approaches with their mechanisms, including interaction with the bacterial cell wall, inhibition of biofilm formations, activation of innate and adaptive host immune response, generation of reactive oxygen species, and induction of intracellular effect to fight against antibiotic resistance. A section of this article demonstrated the findings related to the development of delivery systems. Lastly, the role of microfluidics in fighting antimicrobial resistance has been discussed. Overall, this review article is an amalgamation of various strategies to study the role of novel approaches and their mechanism to fight against the resistance developed to the antimicrobial therapies.

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Trosheva, K. S., S. A. Sorokina, А. А. Efimova, P. I. Semenyuk, A. K. Berkovich, A. A. Yaroslavov und Z. B. Shifrina. „Interaction of multicomponent anionic liposomes with cationic pyridylphenylene dendrimer: Does the complex behavior depend on the liposome composition?“ Biochimica et Biophysica Acta (BBA) - Biomembranes 1863, Nr. 12 (Dezember 2021): 183761. http://dx.doi.org/10.1016/j.bbamem.2021.183761.

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Roy, Biplab, Amiya Kumar Panda, Srinivas Parimi, Igor Ametov, Timothy Barnes und Clive A. Prestidge. „Physico-chemical Studies on the Interaction of Dendrimers with Lipid Bilayers. 1. Effect of Dendrimer Generation and Liposome Surface Charge“. Journal of Oleo Science 63, Nr. 11 (2014): 1185–93. http://dx.doi.org/10.5650/jos.ess14081.

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Lombardo, Domenico, Mikhail A. Kiselev und Maria Teresa Caccamo. „Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine“. Journal of Nanomaterials 2019 (27.02.2019): 1–26. http://dx.doi.org/10.1155/2019/3702518.

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The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.

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Lee, Hwankyu. „Molecular Simulations of PEGylated Biomolecules, Liposomes, and Nanoparticles for Drug Delivery Applications“. Pharmaceutics 12, Nr. 6 (10.06.2020): 533. http://dx.doi.org/10.3390/pharmaceutics12060533.

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Since the first polyethylene glycol (PEG)ylated protein was approved by the FDA in 1990, PEGylation has been successfully applied to develop drug delivery systems through experiments, but these experimental results are not always easy to interpret at the atomic level because of the limited resolution of experimental techniques. To determine the optimal size, structure, and density of PEG for drug delivery, the structure and dynamics of PEGylated drug carriers need to be understood close to the atomic scale, as can be done using molecular dynamics simulations, assuming that these simulations can be validated by successful comparisons to experiments. Starting with the development of all-atom and coarse-grained PEG models in 1990s, PEGylated drug carriers have been widely simulated. In particular, recent advances in computer performance and simulation methodologies have allowed for molecular simulations of large complexes of PEGylated drug carriers interacting with other molecules such as anticancer drugs, plasma proteins, membranes, and receptors, which makes it possible to interpret experimental observations at a nearly atomistic resolution, as well as help in the rational design of drug delivery systems for applications in nanomedicine. Here, simulation studies on the following PEGylated drug topics will be reviewed: proteins and peptides, liposomes, and nanoparticles such as dendrimers and carbon nanotubes.

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Tehrani Fateh, Sepand, Lida Moradi, Elmira Kohan, Michael R. Hamblin und Amin Shiralizadeh Dezfuli. „Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications“. Beilstein Journal of Nanotechnology 12 (11.08.2021): 808–62. http://dx.doi.org/10.3762/bjnano.12.64.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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Knauer, Nadezhda, Ekaterina Pashkina und Evgeny Apartsin. „Topological Aspects of the Design of Nanocarriers for Therapeutic Peptides and Proteins“. Pharmaceutics 11, Nr. 2 (21.02.2019): 91. http://dx.doi.org/10.3390/pharmaceutics11020091.

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Supramolecular chemistry holds great potential for the design of versatile and safe carriers for therapeutic proteins and peptides. Nanocarriers can be designed to meet specific criteria for given application (exact drug, administration route, target tissue, etc.). However, alterations in the topology of formulation components can drastically change their activity. This is why the supramolecular topology of therapeutic nanoconstructions has to be considered. Herein, we discuss several topological groups used for the design of nanoformulations for peptide and protein delivery: modification of polypeptide chains by host-guest interactions; packaging of proteins and peptides into liposomes; complexation and conjugation with dendrimers. Each topological type has its own advantages and disadvantages, so careful design of nanoformulations is needed. Ideally, each case where nanomedicine is needed requires a therapeutic construction specially created for that taking into account features of the administration route, target tissue, or organ, properties of a drug, its bioavailability, etc. The wide number of studies in the field of protein delivery by supramolecular and nanocarriers for proteins and peptides evidence their increasing potential for different aspects of the innovative medicine. Although significant progress has been achieved in the field, there are several remaining challenges to be overcome in future.

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Yanar, Fatih, Dario Carugo und Xunli Zhang. „Hybrid Nanoplatforms Comprising Organic Nanocompartments Encapsulating Inorganic Nanoparticles for Enhanced Drug Delivery and Bioimaging Applications“. Molecules 28, Nr. 15 (27.07.2023): 5694. http://dx.doi.org/10.3390/molecules28155694.

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Organic and inorganic nanoparticles (NPs) have attracted significant attention due to their unique physico-chemical properties, which have paved the way for their application in numerous fields including diagnostics and therapy. Recently, hybrid nanomaterials consisting of organic nanocompartments (e.g., liposomes, micelles, poly (lactic-co-glycolic acid) NPs, dendrimers, or chitosan NPs) encapsulating inorganic NPs (quantum dots, or NPs made of gold, silver, silica, or magnetic materials) have been researched for usage in vivo as drug-delivery or theranostic agents. These classes of hybrid multi-particulate systems can enable or facilitate the use of inorganic NPs in biomedical applications. Notably, integration of inorganic NPs within organic nanocompartments results in improved NP stability, enhanced bioavailability, and reduced systemic toxicity. Moreover, these hybrid nanomaterials allow synergistic interactions between organic and inorganic NPs, leading to further improvements in therapeutic efficacy. Furthermore, these platforms can also serve as multifunctional agents capable of advanced bioimaging and targeted delivery of therapeutic agents, with great potential for clinical applications. By considering these advancements in the field of nanomedicine, this review aims to provide an overview of recent developments in the use of hybrid nanoparticulate systems that consist of organic nanocompartments encapsulating inorganic NPs for applications in drug delivery, bioimaging, and theranostics.

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Jabarkhil, Merjan, Ayisha S. Azizi, Syeda Zubia Imam, Abdulrahman Alrabbat, Khawaja Danyal Hasan und Muhammad Hasibul Hasan. „Revolutionising Cancer Diagnosis and Treatment: A Review on Advancements in Nanomaterial-based Theranostics“. International Journal of Engineering Materials and Manufacture 8, Nr. 4 (20.10.2023): 106–23. http://dx.doi.org/10.26776/ijemm.08.04.2023.03.

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The persistent struggle against cancer has given rise to the development of nanotheranostics, a domain that integrates therapeutic and diagnostic capabilities within nanoscale structures. This paper explores advancements in nanomaterials and nanoparticles for cancer nanotheranostics, focusing on their design, significance, and applications. The incorporation of biocompatible nanoparticles in cancer therapy offers personalised, targeted approaches while minimising side effects. The use of nanomaterials such as metals, polymers, and lipids enable precise drug delivery and imaging. Various imaging modalities, including ultrasound and fluorescence, complement therapeutic strategies for enhanced precision. Critical parameters for nanomaterial selection and design are discussed, emphasising biocompatibility, targeting efficiency, and drug delivery capacity. Biocompatibility ensures safe interactions within biological systems, requiring mitigation of toxicological concerns through strategies like anti-inflammatory peptides or ligand-functionalization. Targeting efficiency combines passive and active targeting to enhance specificity, reshaping cancer diagnostics and therapy. Drug delivery capacity is achieved through engineered core-shell structures with distinct properties, including liposomes, micelles, and dendrimers, each tailored for targeted therapy and imaging. This paper also discusses the advancements in the field of cancer treatment using nanotheranostics and its economic impact on the Canadian healthcare systems while following the ethical guidelines towards patients’ consent, privacy, and the proper use of emerging technologies.

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Shende, Pravin, und Gauraja Deshpande. „Disulfide Bond-Responsive Nanotherapeutic Systems for the Effective Payload in Cancer Therapy“. Current Pharmaceutical Design 26, Nr. 41 (12.12.2020): 5353–61. http://dx.doi.org/10.2174/1381612826666200707131006.

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Background: The progressive treatment of cancer using disulfide bond-based therapeutics offers improvement in therapeutic potency of active, reduction in adverse events, prolongation of drug release pattern and on-site action by interacting with neoplastic cell microenvironment. Objective: The objective of this article is to highlight the research carried out on disulfide bond-based drug delivery systems as a potential candidate for cancer treatment. Methods: The article provides an overview of the importance of disulfide bonds in cancer treatment in terms of their properties, mechanism of formation/fragmentation and applications. Properties of disulfide bonds, such as pKa, entropy, and dihedral angle contribute to the structural stability of the bonds in a nanotherapeutic system, while their formation and fragmentation are attributed to the presence of a high concentration of GSH in cancer cells. The article further focuses on various drug delivery systems like dendrimers, liposomes, micelles, etc. involving disulfide cross-linked polymers for the preparation of redox-responsive drug delivery systems. Results: The use of nanotechnology with disulfide bond creates an anticancer drug delivery system with higher target specificity, improved bioavailability, and good therapeutic efficacy. Conclusion: In the near future, the combination of DSB with active, cellular material, stem cell and biological fluid will be considered as a new thrust area for research in healthcare.

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Shcharbin, Dzmitry, Maria Bryszewska, Serge Mignani, Xiangyang Shi und Jean-Pierre Majoral. „Phosphorus dendrimers as powerful nanoplatforms for drug delivery, as fluorescent probes and for liposome interaction studies: A concise overview“. European Journal of Medicinal Chemistry 208 (Dezember 2020): 112788. http://dx.doi.org/10.1016/j.ejmech.2020.112788.

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Baghdadi, Hussam. „Biochemical and pharmacological properties of reporter systems and nanoparticles: For better tumors imaging and treatment“. Majmaah Journal of Health Sciences 11, Nr. 4 (2023): 112. http://dx.doi.org/10.5455/mjhs.2023.04.011.

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Reporter systems can analyze the biochemical and molecular processes in viable cells and organs and help imaging of cancer. That includes gene transcription activity, protein–protein interactions, sub-cellular localization and proteases activities. This helps studying the aspects of neoplastic trans¬formation, drug development, monitoring specific cancer-related events and tracing complex patho¬logical events (angiogenesis, apoptosis, proto-oncogene activity, oncongenes, tumor suppressor genes and tumor promoting signals). Resolution and sensitivity govern the choice of reporters. Nanoparticles have diverse uses (magnetic, catalytic, optical, thermodynamic, and electrochemical). Nanoparti¬cles include aptamers, quantum dots, core-shell silica particles, gold nanoparticles, carbon nanotubes, liposomes, dendrimers, oligonucleotides and magnetic nanoparticles. Superparamagnetic iron oxide nanoparticles (SPIONs) have the advantages of easy visualization using Magnetic resonance imaging (MRI), easy cellular targeting, possibility of generating hyperthermia, and easy biodegradation into metabolizable iron particles. Magnetic nanoparticles can be used in chemotherapy, magnetic hyper¬thermia, photodynamic therapy and photothermal therapy. MRI is the most valuable noninvasive imaging techniques to overcome magnetic nanoparticles colloidal instability. In conclusion, SPIONs are among the best nanoparticles to date owing to their easy visualization using MRI, easy cellular targeting, possibility of generating hyperthermia, and easy biodegradation into metabolizable iron particles. Research regarding reporter systems and nanoparticles is quite interesting and challenging. More research efforts are needed to optimize in vivo cancer imaging and therapeutics monitoring.

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Alshamrani, Meshal. „Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials“. Polymers 14, Nr. 6 (17.03.2022): 1221. http://dx.doi.org/10.3390/polym14061221.

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Nanotechnology is an important branch of science in therapies known as “nanomedicine” and is the junction of various fields such as material science, chemistry, biology, physics, and optics. Nanomaterials are in the range between 1 and 100 nm in size and provide a large surface area to volume ratio; thus, they can be used for various diseases, including cardiovascular diseases, cancer, bacterial infections, and diabetes. Nanoparticles play a crucial role in therapy as they can enhance the accumulation and release of pharmacological agents, improve targeted delivery and ultimately decrease the intensity of drug side effects. In this review, we discussthe types of nanomaterials that have various biomedical applications. Biomolecules that are often conjugated with nanoparticles are proteins, peptides, DNA, and lipids, which can enhance biocompatibility, stability, and solubility. In this review, we focus on bioconjugation and nanoparticles and also discuss different types of nanoparticles including micelles, liposomes, carbon nanotubes, nanospheres, dendrimers, quantum dots, and metallic nanoparticles and their crucial role in various diseases and clinical applications. Additionally, we review the use of nanomaterials for bio-imaging, drug delivery, biosensing tissue engineering, medical devices, and immunoassays. Understandingthe characteristics and properties of nanoparticles and their interactions with the biological system can help us to develop novel strategies for the treatment, prevention, and diagnosis of many diseases including cancer, pulmonary diseases, etc. In this present review, the importance of various kinds of nanoparticles and their biomedical applications are discussed in much detail.

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Abdellatif, Ahmed A. H., Hamdoon A. Mohammed, Riaz A. Khan, Varsha Singh, Abdellatif Bouazzaoui, Mohammad Yusuf, Naseem Akhtar et al. „Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity“. Nanotechnology Reviews 10, Nr. 1 (01.01.2021): 1493–559. http://dx.doi.org/10.1515/ntrev-2021-0096.

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Abstract This review focuses on nano-structured delivery devices prepared from biodegradable and biocompatible natural and synthetic polymers, organic raw materials, metals, metal oxides, and their other compounds that culminated in the preparation of various nano-entities depending on the preparative techniques, and starting raw materials’ utilizations. Many nanoparticles (NPs) made of polymeric, metallic, magnetic, and non-magnetic origins, liposomes, hydrogels, dendrimers, and other carbon-based nano-entities have been produced. Developments in nanomaterial substrate and end products’ design, structural specifications, preparative strategies, chemo-biological interfacing to involve the biosystems interactions, surface functionalization, and on-site biomolecular and physiology-mediated target-specific delivery concepts, examples, and applications are outlined. The inherent toxicity, and safety of the design concepts in nanomaterial preparation, and their applications in biomedical fields, especially to the organs, cellular and sub-cellular deliveries are deliberated. Bioapplications, the therapeutic delivery modules’ pharmacokinetics and medicinal values, nanopharmaceutical designs, and their contributions as nano-entities in the healthcare biotechnology of drug delivery domains have also been discussed. The importance of site-specific triggers in nano-scale deliveries, the inherent and induced structural specifications of numerous nanomaterial entities belonging to NPs, nano-scale composites, nano-conjugates, and other nano-devices of organic and inorganic origins, near biological systems are detailed. Modifications that provide nano-deliveries of their intrinsic therapeutic actions, through structural and physicochemical characteristics modifications, and the proven success of various nano-delivery devices and currently available commercial nanomedicinal and nanopharmaceutical products are also provided.

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Tsogas, Ioannis, Dimitris Tsiourvas, George Nounesis und Constantinos M. Paleos. „Modeling Cell Membrane Transport: Interaction of Guanidinylated Poly(propylene imine) Dendrimers with a Liposomal Membrane Consisting of Phosphate-Based Lipids“. Langmuir 22, Nr. 26 (Dezember 2006): 11322–28. http://dx.doi.org/10.1021/la0620861.

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Nguyen, Thi-Thao-Linh, Van-An Duong und Han-Joo Maeng. „Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability“. Pharmaceutics 13, Nr. 7 (20.07.2021): 1103. http://dx.doi.org/10.3390/pharmaceutics13071103.

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P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors, including small molecule drugs, natural constituents, and pharmaceutically inert excipients, have been exploited to overcome P-gp efflux and enhance the oral absorption and bioavailability of many P-gp substrates. The co-administration of small molecule P-gp inhibitors with P-gp substrates can result in drug–drug interactions and increased side effects due to the pharmacological activity of these molecules. On the other hand, pharmaceutically inert excipients, including polymers, surfactants, and lipid-based excipients, are safe, pharmaceutically acceptable, and are not absorbed from the gut. Notably, they can be incorporated in pharmaceutical formulations to enhance drug solubility, absorption, and bioavailability due to the formulation itself and the P-gp inhibitory effects of the excipients. Different formulations with inherent P-gp inhibitory activity have been developed. These include micelles, emulsions, liposomes, solid lipid nanoparticles, polymeric nanoparticles, microspheres, dendrimers, and solid dispersions. They can bypass P-gp by different mechanisms related to their properties. In this review, we briefly introduce P-gp and P-gp inhibitors, and we extensively summarize the current development of oral drug delivery systems that can bypass and inhibit P-gp to improve the oral absorption and bioavailability of P-gp substrates. Since many drugs are limited by P-gp-mediated efflux, this review is helpful for designing suitable formulations of P-gp substrates to enhance their oral absorption and bioavailability.

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Bai, Ding-Ping, Xin-Yu Lin, Yi-Fan Huang und Xi-Feng Zhang. „Theranostics Aspects of Various Nanoparticles in Veterinary Medicine“. International Journal of Molecular Sciences 19, Nr. 11 (24.10.2018): 3299. http://dx.doi.org/10.3390/ijms19113299.

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Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rodents extensively, still either studies or applications in veterinary medicine is not up to the level when compared to applications to human beings. The application in veterinary medicine and animal production is still relatively innovative. Recently, in the era of health care technologies, Veterinary Medicine also entered into a new phase and incredible transformations. Nanotechnology has tremendous and potential influence not only the way we live, but also on the way that we practice veterinary medicine and increase the safety of domestic animals, production, and income to the farmers through use of nanomaterials. The current status and advancements of nanotechnology is being used to enhance the animal growth promotion, and production. To achieve these, nanoparticles are used as alternative antimicrobial agents to overcome the usage alarming rate of antibiotics, detection of pathogenic bacteria, and also nanoparticles being used as drug delivery agents as new drug and vaccine candidates with improved characteristics and performance, diagnostic, therapeutic, feed additive, nutrient delivery, biocidal agents, reproductive aids, and finally to increase the quality of food using various kinds of functionalized nanoparticles, such as liposomes, polymeric nanoparticles, dendrimers, micellar nanoparticles, and metal nanoparticles. It seems that nanotechnology is ideal for veterinary applications in terms of cost and the availability of resources. The main focus of this review is describes some of the important current and future principal aspects of involvement of nanotechnology in Veterinary Medicine. However, we are not intended to cover the entire scenario of Veterinary Medicine, despite this review is to provide a glimpse at potential important targets of nanotechnology in the field of Veterinary Medicine. Considering the strong potential of the interaction between the nanotechnology and Veterinary Medicine, the aim of this review is to provide a concise description of the advances of nanotechnology in Veterinary Medicine, in terms of their potential application of various kinds of nanoparticles, secondly we discussed role of nanomaterials in animal health and production, and finally we discussed conclusion and future perspectives of nanotechnology in veterinary medicine.

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Kaur, Gurleen, Zaquiyya Naaz, Kapil Kumar und Deepak Teotia. „Development and Evaluation of Aceclofenac Liposomes“. Asian Journal of Dental and Health Sciences 1, Nr. 1 (25.12.2021): 24–32. http://dx.doi.org/10.22270/ajdhs.v1i1.8.

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This review gives concise information about the application of dendrimers as drug delivery carrier in the field of drug delivery. Due to their unique architecture these have improved physical and chemical properties. Due to their terminal groups these show high solubility, miscibility and reactivity. Dendrimers have well defined size, shape, molecular weight and monodispersity. These properties make the dendrimers a suitable carrier in drug delivery application. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs. Their compatibility with DNA, heparin and polyanions make them more versatile. Dendrimers, also referred as modern day polymers, they offer much more good properties than the conventional polymers. Due to their multivalent and mono disperse character dendrimers have stimulated wide interest in the field of chemistry biology, drug delivery, gene therapy and chemotherapy. Self-assembly produces a faster means of generating nanoscopic functional and structural systems. But their actual utility in drug delivery can be assessed only after deep understanding of factors affecting their properties and their behaviour in vivo. Keywords: Dendrimers, Drug targeting, nanoscale carriers.

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Wagner, Jessica, Marcel Dillenburger, Johanna Simon, Jennifer Oberländer, Katharina Landfester, Volker Mailänder, David Y. W. Ng, Klaus Müllen und Tanja Weil. „Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers“. Chemical Communications 56, Nr. 61 (2020): 8663–66. http://dx.doi.org/10.1039/d0cc02486d.

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Sk, Ugir Hossain, und Chie Kojima. „Dendrimers for theranostic applications“. Biomolecular Concepts 6, Nr. 3 (01.06.2015): 205–17. http://dx.doi.org/10.1515/bmc-2015-0012.

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AbstractRecently, there have been tremendous advances in the development of various nanotechnology-based platforms for diagnosis and therapy. These nanoplatforms, which include liposomes, micelles, polymers, and dendrimers, comprise highly integrated nanoparticles that provide multiple functions, such as targeting, imaging, and therapy. This review focuses on dendrimer-based nanocarriers that have recently been developed for ‘theranostics (or theragnosis)’, a combination of therapy and diagnostics. We discuss the in vitro and in vivo applications of these nanocarriers in strategies against diseases including cancer. We also explore the use of dendrimers as imaging agents for fluorescence imaging, magnetic resonance imaging, X-ray computed tomography, and nuclear medical imaging.

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Parker, James P., Ziga Ude und Celine J. Marmion. „Exploiting developments in nanotechnology for the preferential delivery of platinum-based anti-cancer agents to tumours: targeting some of the hallmarks of cancer“. Metallomics 8, Nr. 1 (2016): 43–60. http://dx.doi.org/10.1039/c5mt00181a.

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A comprehensive overview showcasing how liposomes, nanocapsules, polymers, dendrimers, nanoparticles and nanotubes may be employed as vehicles to selectively deliver cytotoxic platinum drug payloads to tumour cells.

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Karoonuthaisiri, Nitsara, Kerill Titiyevskiy und James L. Thomas. „Destabilization of fatty acid-containing liposomes by polyamidoamine dendrimers“. Colloids and Surfaces B: Biointerfaces 27, Nr. 4 (März 2003): 365–75. http://dx.doi.org/10.1016/s0927-7765(02)00115-7.

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Shiba, Hiroya, Tomoka Hirose, Yunshen Fu, Masataka Michigami, Ikuo Fujii, Ikuhiko Nakase, Akikazu Matsumoto und Chie Kojima. „T Cell-Association of Carboxy-Terminal Dendrimers with Different Bound Numbers of Phenylalanine and Their Application to Drug Delivery“. Pharmaceutics 15, Nr. 3 (09.03.2023): 888. http://dx.doi.org/10.3390/pharmaceutics15030888.

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T cells play important roles in various immune reactions, and their activation is necessary for cancer immunotherapy. Previously, we showed that polyamidoamine (PAMAM) dendrimers modified with 1,2-cyclohexanedicarboxylic acid (CHex) and phenylalanine (Phe) underwent effective uptake by various immune cells, including T cells and their subsets. In this study, we synthesized various carboxy-terminal dendrimers modified with different bound numbers of Phe and investigated the association of these dendrimers with T cells to evaluate the influence of terminal Phe density. Carboxy-terminal dendrimers conjugating Phe at more than half of the termini exhibited a higher association with T cells and other immune cells. The carboxy-terminal Phe-modified dendrimers at 75% Phe density tended to exhibit the highest association with T cells and other immune cells, which was related to their association with liposomes. A model drug, protoporphyrin IX (PpIX), was encapsulated into carboxy-terminal Phe-modified dendrimers, which were then used for drug delivery into T cells. Our results suggest the carboxy-terminal Phe-modified dendrimers are useful for delivery into T cells.

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Kuche, Kaushik, Rahul Maheshwari, Vishakha Tambe, Kit-Kay Mak, Hardi Jogi, Nidhi Raval, Mallikarjuna Rao Pichika und Rakesh Kumar Tekade. „Carbon nanotubes (CNTs) based advanced dermal therapeutics: current trends and future potential“. Nanoscale 10, Nr. 19 (2018): 8911–37. http://dx.doi.org/10.1039/c8nr01383g.

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The search for effective and non-invasive delivery modules to transport therapeutic molecules across skin has led to the discovery of a number of nanocarriers (viz.: liposomes, ethosomes, dendrimers,etc.) in the last few decades.

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WANG, Yanming. „Interaction between poly(amidoamine) dendrimers“. Chinese Science Bulletin 50, Nr. 19 (2005): 2161. http://dx.doi.org/10.1360/982005-83.

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Contin, Mario, Cybele Garcia, Cecilia Dobrecky, Silvia Lucangioli und Norma D’Accorso. „Advances in drug delivery, gene delivery and therapeutic agents based on dendritic materials“. Future Medicinal Chemistry 11, Nr. 14 (Juli 2019): 1791–810. http://dx.doi.org/10.4155/fmc-2018-0452.

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Dendrimers are synthetic polymers that grow in three dimensions into well-defined structures. Their morphological appearance resembles a number of trees connected by a common point. Dendritic nanoparticles have been studied for a large number of pharmaceutical and biomedical applications including gene and drug delivery, clinical diagnosis and MRI. Despite the application of dendrimers, research is still in its childhood in comparison with liposomes and other nanomaterials. They are now playing a key role in several therapeutic strategies, with dendrimer-based products in clinical trials. The aim of this review is to describe the state-of-the-art of biomedical applications of dendrimers – and dendrimer conjugates – such as drug and gene delivery and antiviral activity.

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Yavuz, Burçin, Sibel Bozdağ Pehlivan und Nurşen Ünlü. „Dendrimeric Systems and Their Applications in Ocular Drug Delivery“. Scientific World Journal 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/732340.

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Ophthalmic drug delivery is one of the most attractive and challenging research area for pharmaceutical scientists and ophthalmologists. Absorption of an ophthalmic drug in conventional dosage forms is seriously limited by physiological conditions. The use of nonionic or ionic biodegradable polymers in aqueous solutions and colloidal dosage forms such as liposomes, nanoparticles, nanocapsules, microspheres, microcapsules, microemulsions, and dendrimers has been studied to overcome the problems mentioned above. Dendrimers are a new class of polymeric materials. The unique nanostructured architecture of dendrimers has been studied to examine their role in delivery of therapeutics and imaging agents. Dendrimers can enhance drug’s water solubility, bioavailability, and biocompatibility and can be applied for different routes of drug administration successfully. Permeability enhancer properties of dendrimers were also reported. The use of dendrimers can also reduce toxicity versus activity and following an appropriate application route they allow the delivery of the drug to the targeted site and provide desired pharmacokinetic parameters. Therefore, dendrimeric drug delivery systems are of interest in ocular drug delivery. In this review, the limitations related to eye’s unique structure, the advantages of dendrimers, and the potential applications of dendrimeric systems to ophthalmology including imaging, drug, peptide, and gene delivery will be discussed.

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Terehova, M. M., V. M. Abashkin, V. A. Zhogla, I. V. Halets-Bui, S. Zh Loznikova, M. Bryshewska, M. Ionov, I. Waczulikova, J. P. Majoral und D. G. Shcharbin. „Interaction of polyamidoamine dendrimers and amphiphylic dendrons with lipid membranes“. Proceedings of the National Academy of Sciences of Belarus, Biological Series 66, Nr. 4 (10.11.2021): 497–512. http://dx.doi.org/10.29235/1029-8940-2021-66-4-497-512.

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Polyamidoamine (PAMAM) dendrimers and amphiphilic dendrons are one of the types of nanomaterials characterized by a hyperbranched structure of polymer branches. In the case of dendrimers, the dendrons are covalently linked at the central focal point. In the case of amphiphilic dendrons, dendrons are non-covalently linked by hydrophobic interactions, forming micellar structures. These nanoparticles are widely used in biology and medicine as contrast agents, carriers of drugs and genetic material. Their use in scientific practice requires an understanding of the basic mechanisms of their interaction with membranes – the main obstacle to the entry of dendrimers into the cell. This review discusses the regularities of the interaction of dendrimers and amphiphilic dendrons with lipid membranes. Various models of dendrimer-membrane interactions are described as the basis for the penetration of dendrimers and amphiphilic nanoparticles into cells. Keywords: polyamidoamine dendrimers, amphiphilic dendrons, lipid membranes, cells, antitumor therapeutics, antibacterial agents, diagnostics, genetic therapy.

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Białkowska, Kamila, Katarzyna Miłowska, Sylwia Michlewska, Paulina Sokołowska, Piotr Komorowski, Tania Lozano-Cruz, Rafael Gomez-Ramirez, Francisco Javier de la Mata und Maria Bryszewska. „Interaction of Cationic Carbosilane Dendrimers and Their siRNA Complexes with MCF-7 Cells“. International Journal of Molecular Sciences 22, Nr. 13 (01.07.2021): 7097. http://dx.doi.org/10.3390/ijms22137097.

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The application of siRNA in gene therapy is mainly limited because of the problems with its transport into cells. Utilization of cationic dendrimers as siRNA carriers seems to be a promising solution in overcoming these issues, due to their positive charge and ability to penetrate cell membranes. The following two types of carbosilane dendrimers were examined: CBD-1 and CBD-2. Dendrimers were complexed with pro-apoptotic siRNA (Mcl-1 and Bcl-2) and the complexes were characterized by measuring their zeta potential, circular dichroism and fluorescence of ethidium bromide associated with dendrimers. CBD-2/siRNA complexes were also examined by agarose gel electrophoresis. Both dendrimers form complexes with siRNA. Moreover, the cellular uptake and influence on the cell viability of the dendrimers and dendriplexes were evaluated using microscopic methods and XTT assay on MCF-7 cells. Microscopy showed that both dendrimers can transport siRNA into cells; however, a cytotoxicity assay showed differences in the toxicity of these dendrimers.

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Silva, Ana, Carla Lopes, José Lobo und Maria Amaral. „Delivery systems for biopharmaceuticals. Part II: Liposomes, Micelles, Microemulsions and Dendrimers“. Current Pharmaceutical Biotechnology 16, Nr. 11 (02.09.2015): 955–65. http://dx.doi.org/10.2174/1389201016666150817094637.

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Moraes, Marli L., Maurício S. Baptista, Rosangela Itri, Valtencir Zucolotto und Osvaldo N. Oliveira. „Immobilization of liposomes in nanostructured layer-by-layer films containing dendrimers“. Materials Science and Engineering: C 28, Nr. 4 (Mai 2008): 467–71. http://dx.doi.org/10.1016/j.msec.2007.04.017.

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Singh, Jaspreet, Keerti Jain, Neelesh Kumar Mehra und N. K. Jain. „Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers“. Artificial Cells, Nanomedicine, and Biotechnology 44, Nr. 7 (08.01.2016): 1626–34. http://dx.doi.org/10.3109/21691401.2015.1129625.

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Torre, Paola, Qi Xiao, Irene Buzzacchera, Samuel E. Sherman, Khosrow Rahimi, Nina Yu Kostina, Cesar Rodriguez-Emmenegger et al. „Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids“. Proceedings of the National Academy of Sciences 116, Nr. 31 (15.07.2019): 15378–85. http://dx.doi.org/10.1073/pnas.1904868116.

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Reconstructing the functions of living cells using nonnatural components is one of the great challenges of natural sciences. Compartmentalization, encapsulation, and surface decoration of globular assemblies, known as vesicles, represent key early steps in the reconstitution of synthetic cells. Here we report that vesicles self-assembled from amphiphilic Janus dendrimers, called dendrimersomes, encapsulate high concentrations of hydrophobic components and do so more efficiently than commercially available stealth liposomes assembled from phospholipid components. Multilayer onion-like dendrimersomes demonstrate a particularly high capacity for loading low-molecular weight compounds and even folded proteins. Coassembly of amphiphilic Janus dendrimers with metal-chelating ligands conjugated to amphiphilic Janus dendrimers generates dendrimersomes that selectively display folded proteins on their periphery in an oriented manner. A modular strategy for tethering nucleic acids to the surface of dendrimersomes is also demonstrated. These findings augment the functional capabilities of dendrimersomes to serve as versatile biological membrane mimics.

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UENO, Masaharu, und Hiroshi KASHIWAGI. „Interaction of Liposomes with Detergents“. Journal of Japan Oil Chemists' Society 49, Nr. 10 (2000): 1131–39. http://dx.doi.org/10.5650/jos1996.49.1131.

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Bacha, Katia, Catherine Chemotti, Jean-Pierre Mbakidi, Magali Deleu und Sandrine Bouquillon. „Dendrimers: Synthesis, Encapsulation Applications and Specific Interaction with the Stratum Corneum—A Review“. Macromol 3, Nr. 2 (01.06.2023): 343–70. http://dx.doi.org/10.3390/macromol3020022.

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Dendrimers are increasingly being studied in the context of encapsulation. Many potential applications of dendrimers are based on their properties. They are used in drug delivery systems, cosmetics, food and chemistry. This review is first devoted to different synthesis approaches for dendrimers and to their ability to encapsulate active molecules. Their applications in different fields, as well as their cytotoxicity, are then detailed. To conclude this review, the main works on the interaction of dendrimers with the stratum corneum (SC) are also presented.

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Udupa, Dr Nayanabhirama. „NOVEL DRUG DELIVERY SYSTEMS: AN OPPORTUNITY FOR PHARMACEUTICAL SCIENTISTS IN INDIA“. INDIAN DRUGS 54, Nr. 12 (28.12.2017): 5–6. http://dx.doi.org/10.53879/id.54.12.p0005.

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Dear Reader, Innumerable drug delivery systems are available for the introduction of the drugs into the body to treat various diseases, to enhance the therapeutic efficacy and to improve patient compliance. These systems include oral controlled systems, parenteral systems, nasal and pulmonary systems, transdermal systems, nanoparticles, dendrimers, lipid based systems (liposomes, nanostructured lipid carriers, etc), self-regulated systems and targeted drug delivery systems.

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Wrobel, Dominika, Radka Kubikova, Monika Müllerová, Tomas Strašák, Květoslav Růžička, Michal Fulem und Jan Maly. „Phosphonium carbosilane dendrimers – interaction with a simple biological membrane model“. Physical Chemistry Chemical Physics 20, Nr. 21 (2018): 14753–64. http://dx.doi.org/10.1039/c7cp07237f.

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Factors such as shielding of charge on dendrimers by bulky substituents and/or hydrophobicity of substituents are important for final ability of dendrimers to interact with and to penetrate deep into the lipid bilayer.

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González Corrales, Daniela, Nathalie Fernández Rojas, Grettel Solís Vindas, Maripaz Santamaría Muñoz, Marianela Chavarría Rojas, Daniela Matarrita Brenes, María Fernanda Rojas Salas und German Madrigal Redondo. „Dendrimers and their applications“. Journal of Drug Delivery and Therapeutics 12, Nr. 1-S (15.02.2022): 151–58. http://dx.doi.org/10.22270/jddt.v12i1-s.5307.

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Dendrimers are symmetric molecules; their size is within the nanoscale. Its structure is usually homogeneous and monodisperse; they are composed of a nucleus and several layers 1. The number of layers that the dendrimer has defines its generation. There are different types of dendrimers. The synthesis of these macromolecules is carried out following steps of growth and activation, and organic reactions are required to obtain their branched structure2. Although size is essential, the determining factor of toxicity in dendrimers is the charge of the surface; it has been found that the higher generation dendrimers and the cationic ones are the most toxic compared to the lower generation anionics that evaluated at low concentrations did not show any toxicity 3. The dendrimers will favor the pharmacokinetics of a drug through the dendritic structure, the generation of the dendrimer to be used, the intramolecular interaction force between the adjacent functional groups in the dendrimer, the conditions of the environment such as pH, solvent polarity, strength ionic, saline concentration or presence of counterions, among others 4. Due to dendrimers' size and surface composition, the use of dendrimers in drug delivery has been increasingly studied. There are different interaction mechanisms between drugs in dendrimers, and these can be broadly divided into simple encapsulation, electrostatic interaction, and covalent bonds 5. The use of dendrimers in ocular administration has greatly impacted the complexity of this administration route. Gene therapy has also benefited from the emergence of these molecules as it facilitates targeted therapy. Keywords: Dendrimers, Drug delivery, Gene therapy, Pharmacokinetic, Transport System

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Pippa, Natassa, Stergios Pispas und Costas Demetzos. „Delivery Nanoparticle Platform of Liposomes—Incorporated Dendrimers: Physicochemical, Morphological and Thermotropic Characterization“. Advanced Science, Engineering and Medicine 7, Nr. 9 (01.09.2015): 805–10. http://dx.doi.org/10.1166/asem.2015.1761.

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