Thematische Bibliographien / Industrial toxicology

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Auswahl der wissenschaftlichen Literatur zum Thema „Industrial toxicology“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 29. Juli 2024

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Zeitschriftenartikel zum Thema "Industrial toxicology"

BRESNITZ, EDDY A. „Clinical Industrial Toxicology“. Annals of Internal Medicine 103, Nr. 6_Part_1 (01.12.1985): 967. http://dx.doi.org/10.7326/0003-4819-103-6-967.

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Thorne, Peter S. „Patty's industrial hygiene and toxicology, Vol. 2: Toxicology“. Chemical Engineering Science 50, Nr. 11 (Juni 1995): 1846–47. http://dx.doi.org/10.1016/0009-2509(95)90007-1.

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Diener, R. M. „Behavioral Toxicology: Current Industrial Viewpoint“. Journal of the American College of Toxicology 6, Nr. 4 (Juli 1987): 427–32. http://dx.doi.org/10.3109/10915818709075687.

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The major factors leading to the increased interest in behavioral toxicology are summarized. Important regulations and guidelines, which are in effect now or are being formulated, are presented in light of their impact on the new discipline. Some issues facing industrial toxicologists are discussed and related to current industry actions and recommendations.

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WATANABE, P. G., T. R. FOX, R. H. REITZ, A. M. SCHUMANN und M. E. ANDERSEN. „RESEARCH STRATEGY IN INDUSTRIAL TOXICOLOGY“. Journal of Toxicological Sciences 12, Nr. 2 (1987): 223–33. http://dx.doi.org/10.2131/jts.12.223.

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Scott, Alister. „Hamilton and Hardy’s Industrial Toxicology“. Occupational Medicine 66, Nr. 7 (07.09.2016): 588. http://dx.doi.org/10.1093/occmed/kqw118.

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Osinubi, Omowunmi Y. O., und Philip J. Landrigan. „Occupational, Industrial and Environmental Toxicology“. American Journal of Industrial Medicine 33, Nr. 1 (Januar 1998): 99. http://dx.doi.org/10.1002/(sici)1097-0274(199801)33:1<99::aid-ajim15>3.0.co;2-0.

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Magos, L. „Patty's Industrial Hygiene and Toxicology“. Journal of Applied Toxicology 16, Nr. 6 (November 1996): 539. http://dx.doi.org/10.1002/(sici)1099-1263(199611)16:6<539::aid-jat375>3.0.co;2-k.

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Minami, Masayasu. „Does Industrial and Environmental Toxicology Have Relevance to Forensic Toxicology?“ Journal of Toxicology: Toxin Reviews 17, Nr. 1 (Januar 1998): 39–55. http://dx.doi.org/10.3109/15569549809006489.

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REINHARDT, Charles F. „MEETING NEW CHALLENGES IN INDUSTRIAL TOXICOLOGY“. Journal of Toxicological Sciences 12, Nr. 2 (1987): 235–41. http://dx.doi.org/10.2131/jts.12.235.

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Behnisch, Peter A. „Principles of Toxicology, Environmental and Industrial Applications: Principles of Toxicology, Environmental and Industrial Applications, 2nd Ed“. Environment International 26, Nr. 1-2 (August 2000): 119. http://dx.doi.org/10.1016/s0160-4120(00)00083-0.

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Dissertationen zum Thema "Industrial toxicology"

Vianna, Gérson de Pinho. „Aspectos gerais da neurotoxicidade associada com a exposição a substâncias químicas na indústria do petróleo“. Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-22012018-124141/.

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A indústria do petróleo possui extensa variedade de riscos ocupacionais em virtude da diversidade de atividades necessárias, seja na extração em águas profundas ou em outros locais isolados como em florestas e desertos, seja no processo de refino cada vez mais assemelhado à petroquímica. Para tanto, os trabalhadores desta indústria possui praticamente todos os riscos ocupacionais, ou seja, físico, químico, biológico. A base energética da sociedade atual é o petróleo não havendo fonte de energia alternativa economicamente viável para a sustentação da economia e indústria nos dias atuais, portanto, mecanismos eficazes de gerenciamento do risco devem ser perseguidos continuamente. Com avanço da higiene ocupacional, legislações modernas e restritivas aos riscos, a exposição ocupacional deste setor tem diminuído de forma bastante representativa nos últimos anos, e valores de limites de tolerância de várias substâncias cada vez menores tem obrigado à equipe de saúde ocupacional a desenvolverem estudos mais aprimorados. Conceitos de biomarcadores de exposição há muito é utilizado, porém falta definição de parâmetros para avaliação do Sistema Nervoso. Vários estudos indicam que exposições a baixas concentrações podem acarretar em dano à saúde, especialmente aos indivíduos que possuem uma susceptibilidade aumentada. Outro fator que merece atenção é a exposição a baixas concentrações de múltiplos agentes concomitantemente, que pode acarretar em efeito sinérgico para agressão aos mais variados órgãos e sistemas e para isso são necessários os biomarcadores de efeitos. Este trabalho visa discutir o papel dos biomarcadores de efeito precoce de neurotoxicidade de modo a preservar a saúde e qualidade de vida dos trabalhadores envolvidos no processo de produção.
The Oil industry has activities in forests, seas, deserts, cities, trough the extraction and transportation of crude oil and posterior transformation into products for consumers. This transformation occurs trough refinement Then people who work in oil companies are submitted to all of the occupational\'s risks, that is, physic , chemic and biological. In our society there is no economically practicable alternative source of energy yet, to support economy and industry, therefore efficient mechanisms of risk\'s management should be always pursuited. The improvement of legislation and occupational\'s hygiene have been reducing contact with chemist\'s products in last years and lesser Threshold Limit Values has been encouraging the occupational\'s health staff to develop better controls. Biomarker\'s conceptions are being used for a long time, but there is a lack of standards\' definition to evaluate the nervous system. Many papers indicate that exposures to low concentrations can cause health injury specially in individuals that have an increased susceptibility. Another fact that deserves attention is the exposure to low concentrations of multiple chemists\' substances concomitantly, which can cause an enlargement of the aggression of many organs and systems. The goal of this study is to discuss the role of the biomarkers of neurotoxicities, to preserve health and quality of life of the individuals who work at the production\'s process.

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Coxon, Leonie Wilson. „Direct and indirect cognitive and psychological consequences of workplace neurotoxic exposure /“. Murdoch University Digital Theses Program, 2009. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20100203.134802.

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Christopher, Yvette. „Inadvertent ingestion exposure to hazardous substances in the workplace“. Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24665.

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Martins, Alzira Maria da Silva. „Reprocessamento e reutilização de cânulas de perfusão“. Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-02092013-181037/.

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Os procedimentos utilizados para reprocessamento e reuso de artigos médicos de uso único não estão normalizados nem avaliados quanto a segurança. Os objetivos deste estudo foram: (i) determinar o tempo de esterilização e aeração de cânulas de perfusão em ambiente industrial; (ii) avaliar os níveis de resíduos de óxido de etileno, concentração de endotoxinas e resistência a tração de cânulas de perfusão após reprocessamento e reuso em ambiente hospitalar. No ambiente industrial as cânulas foram submetidas á esterilização com 450mg/L de 10% de óxido de etileno e 90% de CO2 por um período de 2 horas a uma temperatura de 45 a 55° C, umidade entre 30 e 90% aeração com 26 trocas de ar por hora com temperatura de 35°C. No ambiente hospitalar a cânula aramada TF 36460 foi utilizada em procedimento cirúrgico com circulação extracorpórea; lavada com água potável, desinfecção com detergente enzimático, enxague com água potável, embalada em papel grau cirúrgico e reprocessada por óxido de etileno com concentração de 500mg/L de 12% de óxido de etileno e 88% de Freon com tempo de exposição de 240 minutos, temperatura de 53°C, umidade entre 40-60% e aeração em temperatura ambiente. No ambiente industrial o tempo necessário para redução de 12 ciclos logarítmicos (SAL 10-6), foi de 120 minutos, no ambiente hospitalar foi de 240 minutos. O tempo de aeração variou de 19 a 28 horas na área industrial; e no ambiente hospitalar foi de 28 horas. No segundo reuso a cânula apresentou residual de óxido de etileno de 83,09 ppm; acima do limite especificado (≤_25ppm). Os testes de resistência a tração e determinação da concentração de endotoxinas foram realizados até o quarto reuso não apresentando resultados fora dos limites especificados. O procedimento de reuso nas condições atuais realizado em ambiente hospitalar foi reprovado, pois não atendeu aos requisitos de residual de óxido de etileno descritos na portaria Brasileira Interministerial n° 482.
The procedures used during reprocessing of disposables have not been normalized, nor assessed for safety. The objective of this study is to assess sterility, residual rate of ethylene oxide, pyrogenicity and resistance to traction results observed in perfusion cannulas after the sterilization process in industrial environments and after reprocessing and reuse in the hospital environment. In the industrial environment, the cannulas were submitted to sterilization with 450mg/L of EtO and 90% of CO2 during a period of 2 hours and at a temperature of 45-55°C, humidity ranging from 30 to 90% and aeration of 26 air changes per hour at a temperature of 35°C. For the hospital environment, we selected the TF 36460 wired cannula, and after using it on a surgical procedure with extracorporeal circulation, it was washed with clean water, disinfected with enzymatic detergent, rinsed with clean water, wrapped in surgical paper and reprocessed in 500mg/L ethylene oxide of 12% EtO and 88% Freon and exposed for 240 minutes at a temperature of 53°C, humidity ranging from 40 to 60% and aeration at room temperature. In the industrial environment, the time needed for decreasing 12 logarithm cycles (10-6) was 120 minutes, while in the hospital environment it was 240 minutes. The aeration time ranged between 19 and 28 hours in the industrial area, while in the hospital environment it took 28 hours. In the second reuse the cannula presented residual of ethylene oxide of 83,09 ppm; above of the specified limit (≤25_ppm). The physical test and endotoxins concentration had been carried through until for reuse not presented results out of specified. The currently procedure of reuse in the hospital is disapproved therefore does not take care of the limits of ethylene oxide residues, recommended by Interministerial Brazilian regulation 482.

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Lamb, Judith. „An evaluation of the validity and reliability of chemical exposure assessment tools used under the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Regulation 2006“. Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230152.

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Within the European Union, the Registration, Evaluation, Authorisation and restriction of Chemicals (REACH) Regulation 2006, requires the registration of chemicals by manufacturers and suppliers by a number of deadlines from 2008- 2018. Registrants must prepare a dossier of substance information, incorporating a chemical safety report and exposure assessment for the work activities for which the substance is used. Several computer-based screening (Tier 1) tools mentioned in the REACH guidance are used by Registrants to assess exposure: the ECETOC Targeted Risk Assessment (TRA); STOFFENMANAGER®; the EMKG-EXPO-TOOL and MEASE. As screening tools, they are expected to generate overestimates of exposure, thus allowing identification of situations of concern requiring more detailed assessment. The study aimed to carry out a comprehensive evaluation of the tools' validity, by comparison of their predictions with workplace measurements of inhalation exposure and their reliability, through assessment of consistency of operation by different users. Comparison of tool predictions of exposure with measurement data (n=3941) from a wide range of European and North American sources suggested that the tools generated overestimates in the majority of cases, with exceptions noted in certain process types and substance forms. Extremely large variability was observed in tool outputs generated by a group of representative users (n=146) when assessing identical exposure situations. A small number of input parameters drove most of the variation; the task descriptor, risk management measures and type of setting. Further calibration and review of the tool predictions are required to ensure that they generate consistent overestimates of exposure. Systems should be implemented to reduce between-user variability, for example user certification; round-robin exercises and team-based assessments. The study findings will assist in increasing the consistency of use and validity of the tools, thus increasing the overall levels of worker health protection and minimising unnecessary business risk management expenditure on redundant exposure controls.

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Berglund, Åsa. „Responses to reduced industrial metal emissions : An ecotoxicological study on Pied Flycatcher (Ficedula hypoleuca, Aves)“. Doctoral thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33767.

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Metals have been used by humans for thousands of years, and this has resulted in increased concentrations in the biosphere. The environment around point-sources, such as mines and smelters, are of particular concern, as metals may accumulate to high concentrations, and potentially reach levels toxic to the local flora and fauna. This thesis focuses on the effects on pied flycatcher populations of two such point-sources, a lead mine and enrichment plant, and a sulfide ore smelter. Mining activities at the lead mine ceased in 2001 and pied flycatcher populations were assessed before and after the closure. At the sulfide ore smelter, pied flycatchers were studied during the 1980s. Since then, the metal emissions to air from the smelter (e.g. arsenic, cadmium, copper, mercury, lead and zinc) have been greatly reduced (by 93 – 99%). Pied flycatchers from these two contaminated environments differed in their responses to reduced atmospheric deposition. At the mine site, nestling responses reflected the reduced atmospheric deposition and less lead accumulated in their tissues. However, lead levels were still high enough to cause negative effects on blood status (δ-aminolevulinic acid dehydratase [ALAD], hemoglobin [Hb], hematocrit [ht], and mean cell hemoglobin concentration) and reproduction (reduced clutch size, increased mortality and reduced breeding success), as was observed when the mine was in operation. Along the pollution gradient away from the smelter, nestling concentrations reflected the metal load in the soil pool, accumulating over time, rather than the atmospheric deposition. This resulted in only a minor response to decreased metal deposition (slightly reduced liver lead concentrations at 3.5 – 90 km from the smelter). This suggests that in environments with highly polluted soils, decreased inputs of atmospheric metal deposition have only minor impacts, and recovery from contamination should not be expected within decades. The high metal concentrations in the vicinity of the smelter contributed to poorer blood status (ALAD, Hb and ht), induced oxidative damage and defenses, and decreased reproduction (increased mortality and reduced breeding success). There were only minor improvements in blood and reproductive variables at 3.5 km from the smelter.
Metaller är grundämnen som inte kan bildas eller förstöras av människan. De förekommer i mineraler i berggrunden och finns överallt på jorden. Människans användning av metaller har dock medfört att de återfinns i högre halter i miljön än de annars skulle gjort. Trots att metallerna kan spridas och transporteras långa sträckor med luftmassorna, är det främst kring källorna, såsom metallindustrier, man kan hitta metaller i tillräckligt höga halter för att orsaka skada på växter och djur. I denna avhandling presenteras undersökningar av hur svartvit flugsnappare (Ficedula hypoleuca) påverkas kring två metallindustrier i norra Sverige. Det ena är en numera nedlagd blygruva med anrikningsverk i Laisvall, där vi studerade populationer av svartvit flugsnappare före och efter att industrin stängdes. Det andra är smältverket Rönnskärsverken, utanför Skelleftehamn, som varit i drift sedan 1930-talet. I föroreningsgradienten från smältverket studerades effekter av 20 års kraftigt minskade metallutsläpp till luften som följd av förbättrade reningstekniker. Resultaten kring industrierna visar att fåglarna svarade olika på de minskade metallutsläppen. Kring blygruvan minskade halterna av bly i flugsnapparungar med samma takt som nedfallen (mätt i mossa) och bytesdjuren (myror). Däremot, kring smältverket, var fåglarna fortfarande exponerade för höga halter av de giftiga ämnena arsenik, kadmium, kvicksilver och bly, på i princip samma nivåer som 20 år tidigare, trots att utsläppen minskat med 93 – 98%. Orsaken till detta tros vara skillnader på föroreningsgraden i markens översta lager, mårskiktet. Vi kunde visa att flugsnapparna kring smältverket främst fick i sig metallerna från marken, som efter flera årtionden med utsläpp från industrin innehöll mycket höga metallhalter. Detta kan förklara att fåglarna trots att utsläppen var låga, fortfarande var utsatta för stor metallexponering. Det snabba svaret på minskad metallspridning (bly och zink) som flugsnapparna vid blygruvan visade, antar vi berodde på att mindre mäng metaller fanns i marken. Trots minskningen var metallhalterna i fåglarna vid gruvområdet fortfarande tillräckligt höga för att, liksom vid smältverket, påverka fåglarnas hälsa. De uppvisade bl.a. låga blodvärden och tecken på oxidativ stress. Vidare var ungdödligheten förhöjd, vilket ledde till lägre häckningsframgång. Slutsatsen är att markens innehåll av metaller har stor betydelse för återhämtningsförloppet för svartvit flugsnappare efter minskat metallnedfall, och att en relativt snabb återhämtning kan förväntas i områden med något lägre metallhalter i mårskiktet, medan återhämtning i områden där marken är kraftigt förorenad inte kan förväntas förrän efter flera årtionden, även om nedfallet upphört nästan helt.

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Mutingwende, Nhamo. „Identification of agricultural and industrial pollutants in the Kat River, Eastern Cape and their effect on agricultural products found along the river banks“. Thesis, University of Fort Hare, 2015. http://hdl.handle.net/10353/d1020242.

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There is growing concern that commonly used Pharmaceuticals and Personal Care Products (PPCPs) and pesticides are entering and contaminating drinking water supplies. The use of targeted quantitation of PPCP has been well established but there is an emerging trend to also screen for and identify unexpected environmental pollutants. Chemicals like pesticides hormones and antibiotics are especially of interest because of proven endocrine disrupting effects and a possible development of bacterial resistance. Powerful screening methods are required to detect and quantify the presence of these compounds in our environment. PPCP encompass a wide range of pollutants, including Endocrine Disrupting Compounds (EDC), pesticides, hormones, antibiotics, drugs of abuse, x-ray contrast agents and drinking water disinfection by-products to name a few. In order to properly assess the effects of these compounds on our environment, it is necessary to accurately monitor their presence. The diversity of chemical properties of these compounds makes method development challenging. LC/MS/MS is able to analyse polar, semi-volatile, and thermally labile compounds covering a wide molecular weight range. The new AB SCIEX TripleTOF™5600 LC/MS/MS was used to profile environmental samples for unexpected pollutants, to identify and characterise the chemical composition and structure of the pollutants, and to quantify (based on intensity) the concentration in collected water samples. Liquid Chromatography coupled to tandem Mass Spectrometry (LCMS/ MS) is able to analyse polar, semi-volatile, and thermally labile compounds covering a wide molecular weight range, such as pesticides, antibiotics, drugs of abuse, x-ray contrast agents, drinking water disinfection by-products etc. More recently there is a growing interest from environmental researchers to also screen for and identify non-targeted compounds in environmental samples, including metabolites and degradates, but also completely unexpected pollutants. The new AB SCIEX TripleTOF™5600 LC/MS/MS system is capable of performing highly sensitive and fast MS scanning experiments to search for unknown molecular ions while also performing selective and characteristic MS/MS scanning for further compound identification and, therefore, is the instrument of choice for this challenging task. General unknown screening workflows do not use a target analyte list and compound detection is not based on any prior knowledge, including retention times and information on possible molecular and fragment ions. Therefore, acquired chromatograms are very rich in information and can easily contain thousands of ions from both any compounds present in the sample as well as from the sample matrix itself. Thus, powerful software tools are needed to explore such data to identify the unexpected compound. Water samples were collected both upstream and downstream of two WWTPs (Seymour and Fort Beaufort) and were directly injected on the AB SCIEX TripleTOF™5600 LC/MS/MS after being filtered. 15 sample points along the Kat River, ranging from a point as close to the source as possible to a point just before it joins the Great Fish River were used. The samples collected from the source were used as the control in each of the experiments, the assumption being the closer you get to the source, the less contaminated the water would be for the analysis of pesticides. Points were selected where the Kat River crosses the R67 or on farms where the river was accessible using farm roads. Samples were collected from October 2013 to November 2014.The Peak view software and Analyst software were used in the analysis of PPCPs. The XIC Manager allows you to manage large lists of compounds and perform automatic extracted ion chromatogram (XIC) calculations and review results operations. The results were displayed in the chromatogram pane and the XIC table (see results). The results reported here in this thesis indicate that there is contamination in the Kat River water due to both pesticides and PPCPs. The results also indicate that the food products are also contaminated and hence both the Kat River agricultural produce and its water need to be closely monitored for both pesticide and PPCPs contaminants. Further studies to investigate the quantitative levels of pesticides and PPCPs in the Kat river water to determine if the concentration levels of the detected pesticides are below the reported Maximum Residues Limits will be explored in the future.

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Sanchez, Clovis. „Avaliação da disponibilidade de informações toxicológicas de produtos químicos utilizados no Brasil“. Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/9/9137/tde-18052015-124105/.

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Durante o ciclo de vida dos produtos químicos, é possível que estes sejam lançados no ambiente ou ainda que sejam absorvidos por indivíduos de uma população, podendo ocorrer danos ambientais ou alterações no estado de saúde desses indivíduos expostos. Por haver a possibilidade de riscos à saúde é imprescindível investigá-los nas diversas situações possíveis de exposição, a fim de estabelecer, quando necessário, medidas preventivas ou emergenciais, visando a proteção da população e das demais espécies presentes nos compartimentos ambientais. Um dos requisitos básicos para o processo de avaliação de risco é a identificação dos perigos que os produtos químicos podem oferecer à saúde devido suas propriedades químicas e fisico-químicas. Este estudo teve como finalidade realizar um levantamento sobre a existência de informações relativas à toxicidade e comportamento no ambiente de produtos químicos fabricados, importados e ou com capacidade de produção no Brasil maior que 500 toneladas por ano, os quais não estão sendo objeto de investigação nos principais programas atualmente existentes no mundo destinados à avaliação de risco de substâncias químicas. O método proposto por este estudo possibilitou uma análise crítica da falta de informação sobre dados de produção ou importação de produtos químicos utilizados no Brasil, além de possibilitar o levantamento sobre a existência de informações toxicológicas para produtos químicos fabricados em larga escala no país. Como resultado, foi constatado que apenas 3,9 % de 461 produtos químicos possuem as informações necessárias para o processo de avaliação inicial de risco.
Chemical products during their life cycle may be absorbed by individuals of the population, consequent1y causing environmental damage or interfering in the health of the exposed individuals. Due to the possibility of health risks, it is imperative to evaluate these risks in all possible situations. If needed, prevention and emergency measures, aiming at protecting the population and the species present in the environment, should be established. A basic requirement for risk assessment is the hazard presented to health by chemical products due to their physic-chemical properties. The objective of this paper was to raise the available data related to the toxicity and the impact on the environment of high volume chemicals manufactured, imported or with a production capacity in Brazil greater than 500 t/year, that are not included in the major world programs of risk assessment. The methodology used in this paper enabled a critical analysis of the lack of data on production or imports of chemicals used in Brazil, in addition to the screening of toxicological information for high production volume chemicals produced in Brazil. As a result, it was found that only 3,9% of the 461 chemicals have the information required for a initial risk assessment.

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Nordberg, Anna. „Priority setting strategies for regulatory testing of industrial chemicals“. Licentiate thesis, Stockholm : Philosophy and the History of Technology, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4554.

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Gibson, Jason. „Neurotoxicity of the Industrial Solvent 4-Methylcyclohexanemethanol: Involvement of the GABA Receptor“. Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc799542/.

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A recent chemical spill of 4-Methylcyclohexanemethanol (4-MCHM) in West Virginia left 300,000 people without water. Officials claimed that this compound is not lethally toxic, but potentially harmful if swallowed or inhaled, and can cause eye and skin irritation. Sittig's Handbook of Toxic and Hazardous Chemical Carcinogens reports high exposures from skin contact or inhalation may cause damage to the heart, liver, kidneys, and lungs, and may result in death. However, no quantitative data seem to exist and no references can be found on neurotoxicity. We have investigated the neurotoxicity of 4-MCHM using mammalian nerve cell networks grown on microelectrode arrays. Network spontaneous activity from multiple units (range 48 – 120 per network) were used as the primary readout. Individual units were followed based on spike waveforms digitized at 40 kHz (Plexon MNAP system). Dose response curves show the effective inhibitory concentration at 50 percent decrease (EC50) to average 27.4 microM SD±6.17. However, in the presence of 40 microM bicuculline, a competitive GABAA antagonist, the EC50 shifts to 70.63uM SD ±4.3; implying that early, low concentration exposures to 4-MCHM involve GABA activation. Initial activity loss occurs without active unit loss (defined as 10 or more template threshold crossing per min), indicating functional interference with spike production. Full recovery has not been seen at concentrations above 130 microM, unless the culture was given bicuculline. Direct exposure to 400uM results in immediate, irreversible loss of spike production, followed by necrosis of glia and neurons.

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Bücher zum Thema "Industrial toxicology"

1869-1970, Hamilton Alice, Hardy Harriet L. 1906-1994, Harbison Raymond D und Hamilton Alice 1869-1970, Hrsg. Hamilton & Hardy's industrial toxicology. 5. Aufl. St. Louis: Mosby, 1998.

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1927-, Hess Robert, Thomas Helmut 1951- und Waechter Felix, Hrsg. Toxicology of industrial compounds. London: Taylor & Francis, 1995.

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Plunkett, E. R. Handbook of industrial toxicology. 3. Aufl. New York, N.Y: Chemical Pub. Co., 1987.

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1869-1970, Hamilton Alice, Hardy Harriet L. 1906-1994, Harbison Raymond D und Hamilton Alice 1869-1970, Hrsg. Hamilton & Hardy's industrial toxicology. 5. Aufl. St. Louis: Mosby, 1998.

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Harbison, Raymond D., Marie M. Bourgeois und Giffe T. Johnson, Hrsg. Hamilton & Hardy's Industrial Toxicology. Hoboken, New Jersey: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118834015.

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D, Clayton George, Clayton Florence E und Patty Frank Arthur 1897-1981, Hrsg. Patty's industrial hygiene and toxicology. 4. Aufl. New York: Wiley, 1994.

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1897-1981, Patty Frank Arthur, Clayton George D und Clayton Florence E, Hrsg. Patty's industrial hygiene and toxicology. 4. Aufl. New York: Wiley, 1993.

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1897-1981, Patty Frank Arthur, Clayton George D und Clayton Florence E, Hrsg. Patty's industrial hygiene and toxicology. 4. Aufl. New York: Wiley, 1994.

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L, Harris Robert, Cralley Lester V. 1911- und Cralley Lewis J. 1911-, Hrsg. Patty's industrial hygiene and toxicology. 3. Aufl. New York: Wiley, 1994.

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D, Clayton George, Clayton Florence E und Patty Frank Arthur 1897-1981, Hrsg. Patty's industrial hygiene and toxicology. 4. Aufl. New York: Wiley, 1994.

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Mehr Quellen

Buchteile zum Thema "Industrial toxicology"

Timbrell, John, und Frank A. Barile. „Industrial Toxicology“. In Introduction to Toxicology, 123–33. 4. Aufl. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003188575-9.

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Sargent, Edward V. „Industrial Chemicals“. In Regulatory Toxicology, 253–64. Third edition. | Boca Raton, Florida : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429464737-11.

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Franck, Heinz-Gerhard, und Jürgen Walter Stadelhofer. „Toxicology/Environmental aspects“. In Industrial Aromatic Chemistry, 426–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73432-8_15.

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Henck, Judith W. „Reproductive Toxicology“. In Hamilton & Hardy's Industrial Toxicology, 1197–228. Hoboken, New Jersey: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118834015.ch110.

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Lewandowski, Thomas A. „Developmental Toxicology“. In Hamilton & Hardy's Industrial Toxicology, 1229–40. Hoboken, New Jersey: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118834015.ch111.

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Polanic, David M., und Marek Banasik. „Regulatory Toxicology“. In Hamilton & Hardy's Industrial Toxicology, 1321–30. Hoboken, New Jersey: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118834015.ch121.

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Ragavan, K., Navin Rastogi und Alok Srivastava. „Industrial Food Processing Contaminants“. In Food Toxicology, 395–432. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2016. http://dx.doi.org/10.1201/9781315371443-22.

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Peña-Fernández, Antonio, Mark D. Evans und María de los Ángeles. „Toxicology of Industrial Chemicals“. In Toxicology for the Health and Pharmaceutical Sciences, 221–42. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9780203730584-13.

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Gelbke, H. P. „Industrial Aspects of Risk Assessment“. In Archives of Toxicology, 73–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77260-3_9.

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Etzrodt, Günter. „Chemical Safety, CLP Regulation, Toxicology“. In Industrial Coloration of Plastics, 393–404. München: Carl Hanser Verlag GmbH & Co. KG, 2022. http://dx.doi.org/10.3139/9781569908532.016.

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Konferenzberichte zum Thema "Industrial toxicology"

Briggs, G., und K. Still. „310. Toxicology, Risk Assessment and the Industrial Hygienist“. In AIHce 2001. AIHA, 2001. http://dx.doi.org/10.3320/1.2765843.

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Schaper, M., und K. Detwiler-Okabayashi. „294. Toxicology and Industrial Hygiene Concerns with the Components Used in Formulating Metalworking Fluids“. In AIHce 1997 - Taking Responsibility...Building Tomorrow's Profession Papers. AIHA, 1999. http://dx.doi.org/10.3320/1.2765428.

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Shumilina, M. A., K. A. Nefedova und A. L. Zolkin. „VETERINARY EDUCATION AS A COMPONENT OF MODERN HIGHER SCHOOL IN RUSSIA: A BRIEF RETROSPECTIVE FLASHBACK OF PRE-INDUSTRIAL DEVELOPMENT“. In "International Scientific and Practical Conference" THEORY AND PRACTICE OF VETERINARY PHARMACY, ECOLOGY AND TOXICOLOGY IN AIC ", dedicated to the centenary of the Department of Pharmacology and Toxicology, SPbSUVM. FSBEI HE St. Petersburg SUVM, 2021. http://dx.doi.org/10.52419/3006-2021-2-247-249.

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The article provides a brief historical event series of the formation of the modern appearance of higher veterinary education in Russia - in the Russian Empire and Soviet Russia. Some institutional measures for the formation of a higher school of veterinary medicine, which served as the basis for the subsequent development of veterinary medicine as a scientific direction, are considered. Key words: veterinary

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Swenson, L. J., B. J. Kelman und R. A. Clark. „317. A Successful Alliance of Industrial Hygiene, Toxicology, and Materials Science in the Evaluation of Indoor Air Quality“. In AIHce 1998. AIHA, 1999. http://dx.doi.org/10.3320/1.2762715.

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A. A., Belov, A. V. Deryugina und M. N. Ivashchenko. „CORRECTION OF TECHNOLOGICAL STRESS BY LOW-INTENSITY LASER RADIATION“. In "International Scientific and Practical Conference" THEORY AND PRACTICE OF VETERINARY PHARMACY, ECOLOGY AND TOXICOLOGY IN AIC ", dedicated to the centenary of the Department of Pharmacology and Toxicology, SPbSUVM. FSBEI HE St. Petersburg SUVM, 2021. http://dx.doi.org/10.52419/3006-2021-2-24-25.

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Intensive industrial technologies in animal husbandry lead to an increase in cases of stress and metabolic disorders, which affects the quality of dairy and meat products. It is important to increase the resistance of animals to environmental factors by non-drug methods. The aim of the work is to study the effect of technological stress and low-intensity laser radiation at the cell level.

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Koraag, Meiske Elisabeth, Phetisya Pamela Frederika Sumolang und Roy Massie. „Toxicology of a potential molluscicide derived from the plant Brucea javanica“. In THE 3RD INTERNATIONAL CONFERENCE ON NATURAL SCIENCES, MATHEMATICS, APPLICATIONS, RESEARCH, AND TECHNOLOGY (ICON-SMART2022): Mathematical Physics and Biotechnology for Education, Energy Efficiency, and Marine Industries. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0211316.

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Berichte der Organisationen zum Thema "Industrial toxicology"

Sentcоv, Valentin, Andrei Reutov und Vyacheslav Kuzmin. Electronic training manual "Acute poisoning with alcohols and alcohol-containing liquids". SIB-Expertise, Januar 2024. http://dx.doi.org/10.12731/er0778.29012024.

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In the structure of acute poisonings, ethanol poisoning currently accounts, according to various sources, from 10 to 20%. The mortality rate in poison control centers for ethanol poisoning is 1-2%, but the mortality rate is much higher due to those who died before medical care was provided. The widespread use of methanol and ethylene glycol in various industries and the high mortality rate with late recognition of poisoning with these alcohols determine the high relevance of a detailed study of the clinic, diagnosis and treatment of these poisonings by doctors of various specialties. In particular, toxicologists from health care institutions, anesthesiologists and resuscitators from health care institutions, doctors from specialized emergency medical services teams, and disaster medicine doctors. Competent and timely diagnosis, hospitalization in a specialized hospital and previously started treatment greatly increases the patient’s chances of life and its further quality. This electronic educational resourse consists of six theoretical educational modules: general issues of clinical toxicology, acute poisoning with veratrine, acute poisoning with ethanol, poisoning with methanol, poisoning with ethylene glycol, acute poisoning with other alcohols. The theoretical block of modules is presented by presentations, the text of lectures with illustrations. Control classes in the form of test control accompany each theoretical module. After studying all modules, the student passes the final test control. Mastering the electronic educational resourse will ensure a high level of readiness to provide specialized toxicological care by doctors of various specialties.

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