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Auswahl der wissenschaftlichen Literatur zum Thema „Imagerie par résonance magnétique moléculaire“
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Zeitschriftenartikel zum Thema "Imagerie par résonance magnétique moléculaire"
Zanca, M. „Techniques d'imagerie moléculaire et métabolique en imagerie par résonance magnétique nucléaire“. EMC - Radiologie et imagerie médicale - Principes et techniques - Radioprotection 3, Nr. 1 (Januar 2008): 1–8. http://dx.doi.org/10.1016/s1879-8497(08)72872-3.
Der volle Inhalt der QuelleZanca, Michel. „Les techniques d’imagerie moléculaire et métabolique en imagerie par résonance magnétique nucléaire“. Médecine Nucléaire 31, Nr. 4 (April 2007): 173–82. http://dx.doi.org/10.1016/j.mednuc.2007.03.008.
Der volle Inhalt der QuelleGamondès, Delphine. „Imagerie par résonance magnétique“. Revue du Podologue 9, Nr. 49 (Januar 2013): 22–24. http://dx.doi.org/10.1016/j.revpod.2012.12.006.
Der volle Inhalt der QuelleGarel, Catherine, Guy Sebag, Patricia Hornoy, Monique Elmaleh und Max Hassan. „Imagerie par résonance magnétique fœtale“. EMC - Radiologie et imagerie médicale - Génito-urinaire - Gynéco-obstétricale - Mammaire 1, Nr. 1 (Januar 2006): 1–7. http://dx.doi.org/10.1016/s1879-8543(06)73980-5.
Der volle Inhalt der QuelleMonnier-Cholley, L., und L. Arrivé. „Imagerie par résonance magnétique thoracique“. EMC - Pneumologie 2, Nr. 1 (Februar 2005): 1–8. http://dx.doi.org/10.1016/j.emcpn.2004.09.001.
Der volle Inhalt der QuelleRoy, C. „Imagerie par résonance magnétique du rein“. EMC - Néphrologie 1, Nr. 1 (Januar 2006): 1–9. http://dx.doi.org/10.1016/s1762-0945(09)49040-5.
Der volle Inhalt der QuelleNaggara, N., und P. Y. Brillet. „Imagerie par résonance magnétique du thorax“. EMC - Radiologie et imagerie médicale - Cardiovasculaire - Thoracique - Cervicale 7, Nr. 2 (Mai 2012): 1–10. http://dx.doi.org/10.1016/s1879-8535(12)52728-5.
Der volle Inhalt der QuelleBazot, M., C. Bornier, A. Cortez, S. Uzan und E. Daraï. „Imagerie par résonance magnétique et endométriose“. EMC - Gynécologie 2, Nr. 1 (Januar 2007): 1–9. http://dx.doi.org/10.1016/s0246-1064(07)44640-0.
Der volle Inhalt der QuelleVignaux, Olivier. „Imagerie par résonance magnétique (IRM) cardiaque“. La Presse Médicale 33, Nr. 13 (Juli 2004): 891–95. http://dx.doi.org/10.1016/s0755-4982(04)98779-9.
Der volle Inhalt der QuelleRodrigo, S., M. C. Henry-Feugeas, C. Oppenheim, M. Verny, J. F. Meder und D. Fredy. „Imagerie des démences par résonance magnétique“. La Presse Médicale 33, Nr. 15 (September 2004): 1027–33. http://dx.doi.org/10.1016/s0755-4982(04)98832-x.
Der volle Inhalt der QuelleDissertationen zum Thema "Imagerie par résonance magnétique moléculaire"
Charpigny, Delphine. „Quantification de nanoparticules à base d’oxyde de fer pour l’IRM moléculaire : approche basée sur la déconvolution du défaut de champ magnétique“. Lyon, INSA, 2011. http://theses.insa-lyon.fr/publication/2010ISAL0129/these.pdf.
Der volle Inhalt der QuelleIn magnetic resonance imaging (MRI), there are two types of contrast agents: paramagnetic, "positive" and superparamagnetic "negative" or the "magnetic susceptibility". Contrast agents are increasingly used in MRI for many medical applications (monitoring cell, marking inflammation, therapeutic targeting. . . ). They have become a valuable tool to aid diagnosis. Locate and quantify the contrast agents have become a major issue of the so-called molecular MRI. In this thesis, we focus on superparamagnetic contrast agents like USPIO (Ultrasmall Iron Oxide particles SuperParamagnetic). We propose quantification based on the estimation of the magnetic susceptibility. This approach is based on the deconvolution of the map of non-magnetic field induced by the contrast agent through the local change of magnetic susceptibility. We define the method that implements a model SYMDEF déconvolutif regulated by a filter type CLS (Constrained Least Squares). This approach redefines and quantification of this type of contrast agent within a framework of image restoration. We present an analysis of the method SYMDEF according to various parameters that govern it and a study on the impact of the difference between a lack of ideal field and model integrated with the default method SYMDEF. The method is evaluated on SYMDEF card default magnetic field synthesis. These maps were obtained: by calculating the defect field theory from anatomical and pathological models that we have designed, from the simulation of MR images of these models is by calculating the susceptibility gradient map (SGM) is the map of phase difference. SYMDEF method was also tested on real MR images in vitro and in vivo aggregates of USPIOs. The results demonstrate the feasibility of this method of quantification, including its robustness against noise and the quality of the quantification of the magnetic susceptibility induced by contrast agents as soon as the fault information of field given with good spatial resolution
Quenault, Aurélien. „Apport de l'imagerie par résonance magnétique dans l'accident ischémique transitoire : imagerie moléculaire de l'inflammation et imagerie du système glymphatique“. Caen, 2015. http://www.theses.fr/2015CAEN3150.
Der volle Inhalt der QuelleTransient ischemic attack (TIA) is a transient episode of neurological dysfunction caused by focal ischemia without acute infarction on brain imaging. TIA is major sign of ischemic stroke. Therefore TIA requires rapid assessment to evaluate and manage this risk. However, TIA diagnosis is difficult due to many differential diagnoses. This results in a waste of opportunity for some patients and unnecessary consumption of expensive resources for other. Therefore it is necessary to identify new tools and new approaches to understand the pathophysiology of AIT and for better evaluation. We have developed a preclinical model of TIA in which, thanks to two non-invasive and semi-quantitative techniques of magnetic resonance imaging (MRI) we have: I) shown a deficit of the glymphatic system, a key regulator of the exchanges of metabolites in the extracellular spaces of the brain parenchyma; ii) developed molecular imaging of P-selectin, which can reveal cerebrovascular inflammation after TIA. Imaging of the glymphatic system unmasks tissue abnormalities and may improve the risk assessment after TIA. Molecular imaging of P-selectin could identify vascular territories at risk and areas impacted by the ischemia. The clinical application of these results could improve diagnosis and management in the context of TIA
Lebel, Réjean. „Imagerie moléculaire de la MMP-2“. Thèse, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6644.
Der volle Inhalt der QuelleBonnard, Thomas. „Mise au point de microparticules polysaccharides injectables pour l'imagerie moléculaire de pathologies artérielles“. Thesis, Paris 13, 2014. http://www.theses.fr/2014PA132015/document.
Der volle Inhalt der QuelleCardiovascular diseases and their consequences constitute nowadays a major health issue. Their treatment could be substantially improved with the development of new non invasive diagnostic techniques. The aim of this doctoral project is to develop injectable into blood stream polysaccharide microparticles that would permit molecular imaging of arterial pathologies. From an emulsion- crosslinking process, we synthesized these microparticles which are on the one hand functionalized with fucoidan to target P-Selectin which is expressed at damaged arterial wall, and on the other hand combined with contrast agents to bring an imaging signal. We developed 2 molecular imaging tools dedicated to 2 classical medical imaging modalities. In order to track the microparticles by single photon emission computed tomography, we radiolabeled them with technetium 99m and to detect them by MRI, we loaded them with superparamagnetic nanoparticles of iron oxide. We then have validated the efficiency of these 2 molecular imaging tools with preclinical studies of in vivo small animal imaging of arterial disease models. The obtained results are very promising and these 2 molecular imaging tools have a strong clinical potential for the diagnosis of arterial pathologies. We also have observed that the microparticles tend to migrate though the damaged arterial wall. This specific property could turn out to be very interesting for future works which will consist in using this technology to convey therapeutic molecules directly into the core of the arterial pathologies
Robert, Rémy. „Recherche de biomarqueurs pour l'imagerie moléculaire de l'athérosclérose“. Bordeaux 2, 2006. http://www.theses.fr/2006BOR21324.
Der volle Inhalt der QuelleThis thesis is divided in two parts. Its aim is the development of human monoclonal antibodies of cardiovascular interest. The first part involves the production, the purification and the biochemical analysis of human antibody fragments directed against the αIIbβ3 integrin. The second part described the in vivo selection by phage display of human scFvs targeting atherosclerotic lesions. We have screened in vivo the atherosclerotic plaques of this model with two different combinatorial libraries of human antibodies. Our strategy is based on a substractive screening with normal and atherosclerotic protein-coated filters, allowing the detection of scFvs after one round of in vivo biopanning. This substractive aproach has permitted us to isolate two scFvs specific to atherosclerotic proteins. The development of such antibodies could be useful : (1) in diagnosis for the early detection of atherosclerotic lesions by MRI, (2) in gene therapy, to improve the molecular targeting
Beilvert, Anne. „Synthèse, caractérisation et évaluation in vitro et in vivo d'agents de contraste pour l'imagerie moléculaire du coeur lipidique de la plaque d'athérosclérose“. Paris 13, 2011. http://www.theses.fr/2011PA132004.
Der volle Inhalt der QuelleImaging and quantifying the lipid core is a key to evaluate the risk of rupture of the atherosclerotic plaque. My goal is to develop MR contrast agent that will target the lipid core inside the atherosclerotic plaque. Our hypothesis is to mimic apolipoprotein A1 and mimetic D-4F behavior with lipids. D-4F is a soluble alpha helix peptide that binds to lipids via a cluster of aromatic amino acids. We believe that using a single aromatic amino acid or a combination of aromatic amino acids on a MR platform will efficiently target the lipid core. First, we developed a micellar platform functionalized with tyrosin-O-methylester. This compound was successfully tested in an ApoE-/- mouse model under western diet that develops atherosclerotic plaque. Then, we generalized this approach with a polysaccharide based MR contrast agent. Tyrosine-O-methylester was coupled to this platform as well as trityrosine and L-4F peptide. These compounds were evaluated first by surface plasmon resonance (SPR) on immobilized lipoproteins and then in the ApoE-/- mouse model. In vivo results indicate an enhancement in the atherosclerotic plaque and in the lipid core that validates our hypothesis
Tassali, Nawal. „IRM moléculaire à base de xénon hyperpolarisé par laser“. Versailles-St Quentin en Yvelines, 2012. http://www.theses.fr/2012VERS0030.
Der volle Inhalt der QuelleMagnetic Resonance Imaging (MRI) has a high importance in medicine as it enables the observation of the organs inside the body without the use of radiative or invasive techniques. However it is known to suffer from poor sensitivity. To circumvent this limitation, a key solution resides in the use of hyperpolarized species. Among the entities with which we can drastically increase nuclear polarization, xenon has very specific properties through its interactions with its close environment that lead to a wide chemical shift bandwidth. The goal is thus to use it as a tracer. This PhD thesis focuses on the concept of 129Xe MRI-based sensors for the detection of biological events. In this approach, hyperpolarized xenon is vectorized to biological targets via functionalized host systems, and then localized thanks to fast dedicated MRI sequences. The conception and set-up of a spin-exchange optical pumping device is first described. Then studies about the interaction of the hyperpolarized noble gas with new cryptophanes susceptible to constitute powerful host molecules are detailed. Also the implementation of recent MRI sequences optimized for the transient character of the hyperpolarization and taking profit of the xenon in-out exchange is described. Applications of this approach for the detection of metallic ions and cellular receptors are studied. Finally, our first in vivo results on a small animal model are presented
Sirol, Marc. „Caractérisation de l'athérothrombose en imagerie par résonance magnétique : rôle de l'imagerie moléculaire pour l'évaluation de la plaque vulnérable“. Paris 7, 2007. http://www.theses.fr/2007PA077177.
Der volle Inhalt der QuelleDespite advances in our understanding of the pathogenesis of atherosclerosis and its thrombotic complications remain the leading cause of mortality in Western societies. Identification of high-risk atherosclerotic lesions prone to rupture and thrombosis may greatly decrease the morbidity and mortality associated with atherosclerosis. High-resolution MRI has recently emerged as one of the most promising techniques for the non-invasive study of atherothrombotic disease, as it can characterize plaque composition and monitor its progression. The development of MRI contrast agents that specifically target components of the atherosclerotic plaque may enable non-invasive detection of high-risk lesions. This research focuses on the use of molecular imaging for the identification of high risk or vulnerable plaques in vivo. We demonstrated the ability of fibrin-targeted MR contrast agent (EP-2104R) for detection and age determination of carotid thrombus. In addition, Gadofluorine-enhanced MRI demonstrated its ability of identifying lipid-rich plaques as well as neovessel high density areas in vivo. We established the superiority of molecular imaging compared to high resolution MRI or contrast-enhanced MRI for plaque characterization. This technique allow for allow the identification of high-risk atherosclerotic lesions in-vivo, using a variety of molecules present in atherosclerotic plaques that may serve as targets for specific contrast agents. Ultimately, such agents may enable treatment of "high-risk" patients prior to lesion progression and occurrence of complications, and may allow for better stratification of "high-risk" plaque and "high-risk" patients
Girard, Olivier Maciej. „Apport d’antennes miniatures en matériau supraconducteur en Imagerie par Résonance Magnétique du ciblage moléculaire et cellulaire chez le petit animal“. Paris 11, 2008. http://www.theses.fr/2008PA112037.
Der volle Inhalt der QuelleMagnetic Resonance Imaging (MRI) on small animal models is increasingly needed in biomedical research to develop new diagnostic means. However this technique suffers from a lack of specificity which is still to be improved to detect early degenerative diseases such as cancer. Molecular imaging using targeted Contrast Agents (CA) is a promising tool to reach this goal. We present hereby a cross-disciplinary work with this purpose. A first issue of this work deals with contrast physical principles involved in MRI. A theoretical study allows evidencing the presence of an optimal field strength (~1-1. 5 T) for paramagnetic targeted CA detection. This is validated experimentally. Highly sensitive detection coils made of superconductive material are presented and fully implemented in a clinical 1. 5 T MRI system. An original characterization method of such coils is developed to manage their performances and in order to be used as a tool for new coil designs. This method accounts for the nonlinear behavior of the material. Two in vivo experimental studies are presented in the last part of this work. They were performed on mouse-implanted human tumor models using a new generation of CA developed by Guerbet, a firm involved in this work. It was not possible to validate undoubtedly the specificity of this CA from these first results. However the methodological improvements of this work will allow rationalizing imaging protocols in the near future, and will lead to significant progress in this field of research
Le, Bihan Denis. „Imagerie par résonance magnétique nucléaire des mouvements incohérents microscopiques : application à l'imagerie de la diffusion moléculaire et de la microcirculation dans le domaine biomédical“. Paris 11, 1987. http://www.theses.fr/1987PA112089.
Der volle Inhalt der QuelleBücher zum Thema "Imagerie par résonance magnétique moléculaire"
A, Cabanis E., Effenterre R. van und Guiraud Chaumeil B, Hrsg. Imagerie par résonance magnétique. London: Libbey, 1988.
Den vollen Inhalt der Quelle findenD, Doyon, Hrsg. IRM: Imagerie par résonance magnétique. 4. Aufl. Paris: Masson, 2001.
Den vollen Inhalt der Quelle findenDominique, Doyon, Hrsg. IRM, imagerie par résonance magnétique. 4. Aufl. Paris: Masson, 2004.
Den vollen Inhalt der Quelle findenOlivier, Vigneaux, Hrsg. Imagerie cardiaque: Scanner et IRM. Issy-les-Moulineaux: Masson, 2005.
Den vollen Inhalt der Quelle findenComité consultatif des services médicaux et des services en établissement (Canada). Sous-comité sur les guides relatifs aux programmes institutionnels. Imagerie par résonance magnétique: Guide pour l'établissement de normes régissant les services spéciaux dans les hôpitaux. Ottawa, Ont: Direction des services de la santé, 1986.
Den vollen Inhalt der Quelle findenVion-Dury, Jean. Cours de résonance magnétique: Spectroscopie et imagerie : de la structure magnétique de la matière à la physiologie. Paris: Ellipses, 2002.
Den vollen Inhalt der Quelle findenGerhardt, Paul. Atlas de corrélations anatomiques en tomodensitométrie et imagerie par résonance magnétique. Paris: Flammarion, 1988.
Den vollen Inhalt der Quelle findenmilieu, Canada Direction de l'hygiène du. Lignes directrices sur l'exposition aux champs électromagnétiques provenant d'appareils cliniques à résonance magnétique. Ottawa, Ont: Direction de l'hygiène du milieu, 1987.
Den vollen Inhalt der Quelle findenMöller, Torsten B. Atlas de poche d'anatomie en coupes sériées: Tomodensitométrie et imagerie par résonance magnétique. 2. Aufl. Paris: Flammarion Médecine-sciences, 2001.
Den vollen Inhalt der Quelle findenEmil, Reif, und Bourjat Pierre Trad, Hrsg. Atlas de poche d'anatomie en coupes sériées: Tomodensitométrie et imagerie par résonance magnétique : Tête et cou. 3. Aufl. Paris: Flammarion médecine-sciences, 2008.
Den vollen Inhalt der Quelle findenBuchteile zum Thema "Imagerie par résonance magnétique moléculaire"
Bradač, Gianni Boris, Ron Ferszt und Brian E. Kendall. „Imagerie par résonance magnétique“. In Les méningiomes intracrâniens, 25–35. Paris: Springer Paris, 1991. http://dx.doi.org/10.1007/978-2-8178-0871-0_5.
Der volle Inhalt der Quelle„Imagerie par résonance magnétique“. In Pathologies Musculosquelettiques Douloureuses, 19–21. Elsevier, 2012. http://dx.doi.org/10.1016/b978-2-294-71429-0.00006-6.
Der volle Inhalt der QuelleDillenseger, Jean-Philippe. „Imagerie par résonance magnétique“. In Guide des technologies de l'imagerie médicale et de la radiothérapie, 241–342. Elsevier, 2024. http://dx.doi.org/10.1016/b978-2-294-78317-3.00005-6.
Der volle Inhalt der QuelleGalanaud, D. „Imagerie par résonance magnétique cérébrale“. In Imagerie en réanimation, 81–91. Elsevier, 2007. http://dx.doi.org/10.1016/b978-2-84299-821-9.50004-7.
Der volle Inhalt der QuelleAnstett, P. „Techniques d'angiographie par résonance magnétique“. In Neuro-Imagerie Diagnostique, 145–78. Elsevier, 2018. http://dx.doi.org/10.1016/b978-2-294-75394-7.00004-7.
Der volle Inhalt der Quelle„Imagerie par résonance magnétique (IRM)“. In Méga Guide STAGES IFSI, 1110–11. Elsevier, 2015. http://dx.doi.org/10.1016/b978-2-294-74529-4.00346-3.
Der volle Inhalt der QuelleAlexandre, J., A. Balian, L. Bensoussan, A. Chaïb, G. Gridel, K. Kinugawa, F. Lamazou et al. „Imagerie par résonance magnétique (IRM)“. In Le tout en un révisions IFSI, 1010–11. Elsevier, 2009. http://dx.doi.org/10.1016/b978-2-294-70633-2.50338-3.
Der volle Inhalt der QuelleHallouët, Pascal. „Imagerie par résonance magnétique (IRM)“. In Mémo-guide infirmier, 451. Elsevier, 2010. http://dx.doi.org/10.1016/b978-2-294-71154-1.50094-9.
Der volle Inhalt der QuelleHallouët, Pascal. „Imagerie par résonance magnétique (IRM)“. In Méga Mémo IFSI, 334–35. Elsevier, 2016. http://dx.doi.org/10.1016/b978-2-294-74924-7.50044-0.
Der volle Inhalt der Quelle„13 Imagerie par résonance magnétique“. In Mathématiques pour l’imagerie médicale, 191–206. EDP Sciences, 2021. http://dx.doi.org/10.1051/978-2-7598-2496-0.c014.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Imagerie par résonance magnétique moléculaire"
Gossiome, C., F. Rufino, G. Herve, M. Benassarou, P. Goudot, V. Descroix und G. Lescaille. „Découverte fortuite d’une lésion mandibulaire, un cas de kyste anévrismal“. In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206603020.
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