Zeitschriftenartikel: „Hypoglycemic activities“

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Hanggaresty, Mutiarani Dasha, und Ni Kadek Warditiani. „REVIEW OF POTENTIAL PLANTS IN INDONESIA AS AN ANTIDIABETIC WITH HYPOGLYCEMIC ACTIVITIES“. Journal of Pharmaceutical Science and Application 3, Nr. 2 (01.12.2021): 57. http://dx.doi.org/10.24843/jpsa.2021.v03.i02.p01.

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Background: Diabetes mellitus which is characterized by hyperglycemia is a metabolic disease due to insulin action, defects in insulin secretion, or both. Various studies have shown that herbs that have a hypoglycemic effect can be used in the treatment of diabetes mellitus. Generally, herbs can slow down the complications of diabetes mellitus and improve metabolism. The ability of plants to restore the function of pancreatic tissue to increase insulin production or make it easier for insulin to process glucose is related to the effects of hypoglycemia. Objective: Comparing plants that have a hypoglycemic activity that can be used in the treatment of diabetes mellitus in Indonesia. Methods: studying literature from various databases, websites, national journals, and relevant international journals to identify plants that have hypoglycemic activity. Results: The mechanism A. sativum as a hypoglycemic involves different fiber viscosities; A. vera involved as a hypoglycemic by protecting pancreatic? cells; Asiatic acid in C. asiatica increasing glycolysis by restoring the activity of key enzymes; G. max inhibiting ?-amylase and the stigmasterol increasing the absorption of blood glucose and reducing insulin resistance; P. macrocarpa exert their antidiabetic action via ?-glucosidase modulation, an extra distinctive pancreatic mechanism; S. arvensis has the potential to inhibit ?-amylase enzymes. Conclusions: This review article has presented 6 detailed comparisons of plants that have a hypoglycemic activity that can be used in the treatment of diabetes mellitus in Indonesia and we believe can be useful for students, researchers, or practitioners. Keywords: Diabetes mellitus, hypoglycemia, Indonesian plants

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Arya, Aditya, Shaik Nyamathulla, Mohamed Ibrahim Noordin und Mustafa Ali Mohd. „Antioxidant and Hypoglycemic Activities of Leaf Extracts of Three PopularTerminaliaSpecies“. E-Journal of Chemistry 9, Nr. 2 (2012): 883–92. http://dx.doi.org/10.1155/2012/859831.

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This study aimed to ascertain the antioxidant and hypoglycemic activity of methanolic extracts of the leaves ofTerminalia arjuna, T. bellerica, andT. chebula. Extracts were evaluated for total phenolic, flavonoid, and tannin content, andin vitroantioxidant potential with DPPH, ORAC, and FRAP assays. The extracts' hypoglycemic activities were evaluated by hypoglycemic screening and an oral glucose tolerance test (OGTT) in normal rats. The methanolic extracts ofT. chebulaleaves exhibited the highest quantity of total phenolic and flavonoid content, followed by those ofT. bellericaandT. arjuna. T. arjunacontained more tannin thanT. bellericadid, but less than that ofT. chebula. The scavenging capacity ofT. chebulafor the antioxidant DPPH was the highest of the extracts tested, as it recorded the lowest IC50 value of all 3 extracts. Likewise, the results attributed theT. chebulaextract with the highest oxygen radical absorption capacity (ORAC). In the FRAP assay, the extracts' ferric reducing antioxidant abilities wereT. arjuna>T. chebula>T. bellerica. This correlates the potential of polyphenolic content enriched with antioxidant capabilities and substantiates the results of the hypoglycemic screening and OGTT, which determined that theT. chebulaextract had a better hypoglycemic effect in normal and glucose-induced hyperglycemic rats (p<0.001) than that ofT. bellericaandT. arjuna, respectively. The use of these Terminalia species as food supplements may help in reducing oxidative stress and related diabetic complications. The phytoconstituents responsible for the hypoglycemic activity need to be isolated to elucidate the relationship between the extracts' antioxidant capacity and their hypoglycemic effects.

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Zhang, Entan, Anker Jon Hansen, Tadeusz Wieloch und Martin Lauritzen. „Influence of MK-801 on Brain Extracellular Calcium and Potassium Activities in Severe Hypoglycemia“. Journal of Cerebral Blood Flow & Metabolism 10, Nr. 1 (Januar 1990): 136–39. http://dx.doi.org/10.1038/jcbfm.1990.18.

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The purpose of the present study was to examine the effect of blockade of N-methyl-d-aspartate (NMDA) receptors on the depolarization associated with severe hypoglycemia, which is commonly preceded by one or a few transient depolarizations reminiscent of cortical spreading depression (CSD). In the cerebral cortices of rats [K+]e and [Ca2 +]e were measured with ionselective microelectrodes. NMDA blockade was achieved by injection of MK801 in doses that block CSD. In control rats, the latency from the time point when blood glucose reached minimal levels to onset of ionic shifts was 33.2 ± 3.5 min, and [K+]e rose from 3.2 ± 0.2 to 55 ± 5 m M. All variables remained unchanged in rats treated with MK801. In another four rats treated with MK801, [Ca2+]e declined from 1.06 ± 0.22 to 0.12 ± 0.02 m M. Plasma glucose measurements indicated that the cortex depolarized at a plasma glucose concentration between 0.7 and 0.8 m M, i.e., within a narrow range, suggesting a threshold phenomenon. In conclusion, activation of NMDA receptors seems of minor importance for hypoglycemic depolarization. The ionic transients that precede the persistent hypoglycemic depolarization are probably mediated by mechanisms distinct from those of electrically induced CSD.

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Dasgupta, Tumpa, Amlan Ganguly, Muhammad Asaduzzaman und Nazmul Qais. „Evaluation of Anti-microbial, Hypoglycemic and Anti-diarrheal activities of Setaria italica Seeds“. Dhaka University Journal of Pharmaceutical Sciences 15, Nr. 1 (08.08.2016): 31–35. http://dx.doi.org/10.3329/dujps.v15i1.29190.

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The ethanolic crude extract of Setaria italica seeds (Poaceae) was investigated for its possible anti-microbial, hypoglycemic and anti-diarrheal activities. Anti-microbial activity was evaluated by disc diffusion method while the hypoglycemic and anti-diarrheal properties were determined by oral glucose tolerance test and castor oil induced diarrheal method, respectively in Albino mice. The ethanolic extract and its different fractions of S. italica have shown good antimicrobial activity against gram negative bacteria having zone of inhibition 9-13 mm (ciprofloxacin: 40- 41 mm). In evaluation of hypoglycemic activity, ethanolic extract and its chloroform fraction, at 400 mg/kg, also showed promising hypoglycemic property having blood glucose level of 3.74 and 3.72 mmol/l after 120 minute, respectively when compared to standard glibenclamide (3.44 mmol/l). On the other hand, during the assessing for anti-diarrheal activity, the crude extract did not significantly reduce the frequency of defecation. The findings of the studies demonstrate anti-microbial and hypoglycemic properties of S. italica.Dhaka Univ. J. Pharm. Sci. 15(1): 31-35, 2016 (June)

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Siddiqui, Sadaf, Neetesh Kumar Jain und Narendra Silawat. „Antidiabetic Activities of Extracts of Ficus bengalensis Linn“. International Journal of Medical Sciences and Pharma Research 8, Nr. 2 (15.06.2022): 35–38. http://dx.doi.org/10.22270/ijmspr.v8i2.35.

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Abstract: Various extracts of diverse parts of medicinal plants have been shown to possess antidiabetic and hypoglycemic effect. Most of them look to act directly on pancreas (pancreatic effect) and stimulate insulin level in blood. Some have extra pancreatic effect by acting directly on tissues like liver, muscle, etc and alter favorably, the activities of the regulatory enzymes of glycolysis, gluconeogenesis and other pathways. The research work embodied in the thesis deals with the scientific exploration of indigenous plants viz., Ficus bengalensis Linn for their possible anti-diabetic and hypoglycemic activity. The present investigations concluded that the ethanolic and aqueous extracts of aerial parts of Ficus bengalensis Linn endowed with potential antidiabetic activity which could be attributed by their possible multiple effects on both pancreatic and extra-pancreatic site by influencing either the metabolism and/or absorption of glucose, which in turn also influence the lipid metabolism. Keywords: hypoglycemic, Ficus bengalensis Linn, Diabetic, Lipid metabolism

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NAKINCHAT, Somrudee, und Voravuth SOMSAK. „A Pilot Study on Antimalarial Effects of Moringa oleifera Leaf Extract in Plasmodium berghei Infection in Mice“. Walailak Journal of Science and Technology (WJST) 15, Nr. 2 (03.11.2017): 151–56. http://dx.doi.org/10.48048/wjst.2018.4593.

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The emergence and spread of antimalarial drug resistance of Plasmodium parasites, as well as hypoglycemia, during malaria infection, and subsequent death, are critical problems in malaria-endemic areas. Hence, finding new compounds, especially plant extracts having antimalarial and anti-hypoglycemic activities, are urgently needed. The present study aimed to investigate the antimalarial and anti-hypoglycemic effects of Moringa oleifera leaf extract in Plasmodium berghei infection in mice. Aqueous crude extract of M. oleifera leaves was freshly prepared and used for an efficacy test in vivo. Groups of ICR mice (5 mice in each) were infected with 1´107 infected red blood cells of P. berghei ANKA by intraperitoneal injection and given the extract orally with doses of 100, 500, and 1000 mg/kg for 4 consecutive days. Parasitemia and plasma glucose levels were subsequently measured. The results showed that M. oleifera leaf extract presented significant (p < 0.001) inhibition of parasitemia in a dose-dependent manner. Moreover, this extract exerted anti-hypoglycemia effects in infected mice in a dose-dependent manner. The highest degrees of activity were found at a dose of 1000 mg/kg of the extract. Additionally, no effect on plasma glucose was found in normal mice treated with this extract. It can be concluded that aqueous crude extract of M. oleifera leaves exerted antimalarial and anti-hypoglycemic effects in P. berghei infection in mice.

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Karim, Irin, Roni Roy, Md Rafiul Hoque, Sazzad Hosen, Tanaya Bhowmik, Israt Jahan Liya, Afroza Akter und Mohammad Anwarul Basher. „Effect of sex differences in antinociceptive, antipyretic, hypoglycemia, hepatoprotective and antidiarrheal activities in mice model“. Journal of Pharmacy & Pharmacognosy Research 8, Nr. 1 (01.01.2020): 569–79. http://dx.doi.org/10.56499/jppres20.911_8.6.569.

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Context: The use of animal models is a longstanding practice in biological research. Among different models, the mouse is the most widely used and accepted model. In designing the mouse model, a male mouse is generally preferred over a female to avoid the effect of changing hormonal state in females. However, it is not known whether mouse sex affects all experiments. Aims: To determine the effect of mouse sex on pharmacological responses in antinociceptive, antipyretic, hypoglycemia, hepatoprotective and antidiarrheal experiments. Methods: Antinociceptive study was performed by three different experiments. An antipyretic experiment was performed by yeast induced hyperthermia test. The effect on hypoglycemic response was assessed by an oral glucose tolerance test. The effect on the hepatoprotective study was evaluated by carbon tetrachloride-induced liver damage. The antidiarrheal study was conducted by a castor oil-induced diarrhea test. Results: Antinociceptive studies demonstrated mixed effects. Hot plate test showed significant differences; the licking test showed variation only in the late phase, while no significant variation was observed. In the antipyretic experiment, female mice showed higher body temperature in both control and standard that varied significantly with male mice. Hypoglycemia and hepatoprotective tests did not show significant variation between sexes; however, liver enzymes levels were found higher in males while the percentage liver weight was higher in females. In the antidiarrheal test, the male mouse was observed to have higher responses than the female. Conclusions: Antinociceptive and antipyretic investigations should be performed separately on both male and female mice. On the other hand, hypoglycemic, hepatoprotective and antidiarrheal tests can be conducted on any mouse sex, and findings on particular sex can be extrapolated to the opposite sex.

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Hao, Jie, Zhiming Qian, Zijian Liu, Guirong Zhang, Di Wang und Weiwei Han. „The Antidiabetic Activities of Neocryptotanshinone: Screened by Molecular Docking and Related to the Modulation of PTP1B“. Nutrients 14, Nr. 15 (24.07.2022): 3031. http://dx.doi.org/10.3390/nu14153031.

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The aim of this study was to provide a practical experimental basis for the development of Neocryptotanshinone (NCTS) as an effective hypoglycemic drug and a theoretical method for the rapid screening of natural compounds with hypoglycemic effects. Molecular docking was used to screen the most suitable ligand. Hematoxylin and eosin, immunohistochemical staining, enzyme-linked immunosorbent assay and Western Blotting approved the hypoglycemic effect of NCTS. According to the free energy of binding, among 180 active compounds from the Traditional Chinese Medicine Integrated Database, NCTS was finally chose for investigation its hypoglycemic effects. In db/db mice, NCTS significantly reduced body weight and plasma glucose, improved glucose tolerance and levels of fasting plasma glucose and glycated hemoglobin A1c, and decreased insulin resistance after six-week administration. NCTS restored the pathological state in the liver of db/db mice and significantly decreased protein tyrosine phosphatase 1B (PTP1B) expression in the liver and muscle of db/db mice, which is related to the regulatory effect of NCTS on insulin receptor substrate 1. In conclusion, we successfully explored the hypoglycemic effect of NCTS in db/db mice via regulating the expression of PTP1B.

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Mansur, Muhammad Abdullah Al, M. Mahboob Ali Siddiqi und Koushik Saha. „Thrombolytic, Membrane Stabilizing and Hypoglycemic Activities of Anethum sowa Linn.“ Dhaka University Journal of Pharmaceutical Sciences 17, Nr. 2 (04.12.2018): 237–41. http://dx.doi.org/10.3329/dujps.v17i2.39181.

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The hexane (HE), dichloromethane (DCME), ethyl acetate (EAE) and methanol (ME) extracts of seed and stem of Anethum sowa were subjected to screenings for thrombolytic, membrane stabilizing and hypoglycemic activities. Ethyl acetate extract of stem showed highest thrombolytic activity. In addition, the dichloromethane, ethyl acetate and methanol extract of seed revealed higher percentage (%) of inhibition in hypotonic solution induced hemolysis. In hypoglycemic activity, the dichloromethane and ethyl acetate extracts of stem and seed displayed significant blood glucose lowering effect. Dhaka Univ. J. Pharm. Sci. 17(2): 237-241, 2018 (December)

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Telushkin, P. K. „The intensity of lipid peroxidation processes, the activity of NADP-dependent dehydrogenases and proteases in rat brain with repeated administration of insulin“. Problems of Endocrinology 44, Nr. 3 (06.06.1998): 35–37. http://dx.doi.org/10.14341/probl199844335-37.

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The rate of accumulation of malonic dialdehyde was increased, the activities of superoxide dismutase, NADP-dependent glucose- 6-phosphate, malate, isocitrate dehydrogenases and glutathione reductase decreased, and the levels of diene conjugates decreased in the hemispheres and brain stem of rats subjected to 7-9 hypoglycemic comas. The activities of neutral and acid proteases were increased in the stem structures. The detected changes indicate an oxidative stress developing in the nerve tissue after repeated hypoglycemic exposures. Such changes appear after glucose arrest of hypoglycemic coma and can be important in the pathogenesis of posthypoglycemic encephalopathy.

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Feng, Shengbao, Lixia Song, Yuancai Liu, Fuli Lai, Gang Zuo, Guangyuan He, Mingjie Chen und Dejian Huang. „Hypoglycemic Activities of Commonly-Used Traditional Chinese Herbs“. American Journal of Chinese Medicine 41, Nr. 04 (Januar 2013): 849–64. http://dx.doi.org/10.1142/s0192415x13500572.

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The α-amylase and α-glucosidase inhibition activity of 92 Traditional Chinese Medicinal (TCM) herbs, which are permitted to be used as food ingredients, were evaluated using the high throughput assay developed in our laboratory. Among these herbs, twenty-seven of them possessed significant α-amylase inhibition activities ranging from 2.4 to 349.2 μmol AE/g (AE = acarbose equivalent) with inhibition concentrations at 50% inhibition (IC50) from 16.0 to 2342.2 μg/mL, respectively. In addition, they showed α-glucosidase inhibition activities ranging from 0.5 to 31.6 μmolAE/g (IC50 from 49.0 to 3385.5 μg/mL). The extracts of Rhizoma fagopyri dibotryis (Jīnqiáomài), Rosa rugosa (Méiguīhuā), Caulis polygoni multiflori (Shǒuwūténg), Fructus amomi (Shārén), Rhizoma alpiniae officinarum (Gāoliángjiāng), Folium ginkgo (Yínxìngyè) and Cortex cinnamomi (Ròuguì) showed the better inhibitory activities against both α-amylase and α-glucosidase. Our results illustrated that these food grade herbs are potent natural hypoglycemic agents and can be used as active ingredients for low glycemic index food production or TCM herbal formulations for controlling hyperglycemia.

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刘, 玉婷. „In Vitro Hypoglycemic and Hypolipidemic Activities of LEP“. Advances in Microbiology 08, Nr. 01 (2019): 22–32. http://dx.doi.org/10.12677/amb.2019.81004.

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Özbek, Hanefi, und Betül Sever Yılmaz. „Anti-inflammatory and hypoglycemic activities of alpha-pinene“. ACTA Pharmaceutica Sciencia 55, Nr. 4 (2017): 7. http://dx.doi.org/10.23893/1307-2080.aps.05522.

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Gupta, Ashok Kumar, Mansi Verma und Gajraj Singh Lodhi. „Protective effect of Ficus infectoria plant extract against fructose induced hyperlipidemia and hyperglycemia in rats“. Journal of Phytopharmacology 3, Nr. 6 (25.12.2014): 431–35. http://dx.doi.org/10.31254/phyto.2014.3610.

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The main aim of this study is to explore the antihyperlipidemic and hypoglycemic potential of the methanolic extract of Ficus infectoria in Wistar rats. Hyperlipidemia and hypoglycemia in rats were induced by fructose solution (10% w/v, p.o., ad libitum) for 3rd and 8th weeks respectively. These activities were measured by estimating the triglyceride, total cholesterol, LDL, VLDL, HDL and serum glucose levels. F. infectoria at 200mg/kg and 400mg/kg showed significant effect. Fructose feeding increased serum biochemical parameters like triglyceride, total cholesterol, LDL, VLDL and serum glucose levels while decreases the HDL level. In fructose fed rats, F. infectoria at 200 mg/kg and 400 mg/kg significantly prevented the increase in serum biochemical parameters while decrease in HDL level. The present study indicates that methanolic extract of F. infectoria has Antihyperlipidemic and hypoglycemic. In future it may be useful in the management of insulin resistant.

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Das, Narhari, Md Sharif Hasan, Sheikh Zahir Raihan und Md Zakir Sultan. „Antinociceptive, Anti-inflammatory and Hypoglycemic Activities of Terminalia citrina Leaves“. Bangladesh Pharmaceutical Journal 19, Nr. 1 (10.08.2016): 25–31. http://dx.doi.org/10.3329/bpj.v19i1.29232.

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The present study was designed to investigate the antinociceptive, anti-inflammatory and hypoglycemic effects of petroleum ether, carbon tetrachloride, dichloromethane and ethyl acetate soluble partitionates of the methanolic extracts of Terminalia citrina leaves. The partitionates of the methanolic extract of the leaves of plant T. citrina at 200 mg/kg and 400 mg/kg were subjected for their antinociceptive activity using both acetic acid induced writhing method and radiant heat tail flicking method; anti-inflammatory activity was evaluated by HRBC membrane stabilization method and hypoglycemic activity by blood glucose level test. The carbon tetrachloride partitionate at 400 mg/kg induced significant decrease in the no. of writhes while the petroleum ether partitionate at 400 mg/kg showed promising activity compared to standard diclofenac sodium. Similarly, the petroleum ether partitionate elongates the reaction time significantly after administration of extract in radiant heat tail flicking method, suggesting central antinociceptive activity and at concentration of 2000 ?g/ml showed promising protection of HRBC in hypotonic solution compared with standard naproxen. On the other hand, in hypoglycemic activity, the ethyl acetate partitionate shows significant activity compared to standard metformin drug.Bangladesh Pharmaceutical Journal 19(1): 25-31, 2016

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Gong, Pin, Yuxi Guo, Xuefeng Chen, Dandan Cui, Mengrao Wang, Wenjuan Yang und Fuxin Chen. „Structural Characteristics, Antioxidant and Hypoglycemic Activities of Polysaccharide from Siraitia grosvenorii“. Molecules 27, Nr. 13 (29.06.2022): 4192. http://dx.doi.org/10.3390/molecules27134192.

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The structural characterization, the in vitro antioxidant activity, and the hypoglycemic activity of a polysaccharide (SGP-1-1) isolated from Siraitia grosvenorii (SG) were studied in this paper. SGP-1-1, whose molecular weight is 19.037 kDa, consisted of Gal:Man:Glc in the molar ratio of 1:2.56:4.90. According to the results of methylation analysis, GC–MS, and NMR, HSQC was interpreted as a glucomannan with a backbone composed of 4)-β-D-Glcp-(1→4)-, α-D-Glcp-(1→4)-, and 4)-Manp-(1 residues. α-1,6 linked an α-D-Galp branch, and α-1,6 linked an α-D-Glcp branch. The study indirectly showed that SGP-1-1 has good in vitro hypoglycemic and antioxidant activities and that these activities may be related to the fact that the SGP-1-1’s monosaccharide composition (a higher proportion of Gal and Man) is the glycosidic-bond type (α- and β-glycosidic bonds). SGP-1-1 could be used as a potential antioxidant and hypoglycemic candidate for functional and nutritional food applications.

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Yusuf, Abubakar A., Toheeb D. Yissa, Abdulhakeem Rotimi Agboola, Sodiq M. Balogun, Peter O. Adeboye, Opeyemi N. Hassan und Iliyasu S. Raji. „Comparative free radical scavenging and hypoglycemic activities of n-hexane, ethyl-acetate, and aqueous fractions of Azanza garckeana pulp“. AROC in Natural Products Research 1, Nr. 2 (18.08.2021): 1–8. http://dx.doi.org/10.53858/arocnpr01020108.

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Background: The prevalence of diabetes mellitus is increasing on a global trend. The aim of the present study is to identify the most effective antioxidants and hypoglycemic fraction of Azanza garckeana. Methods: The fractions (nhexane or ethyl-acetate or aqueous) of A. garckeana were administered to the alloxan-induced diabetic rats at doses of 100, 200, and 400 mg/kg for 15 days. Antioxidants activities were evaluated at concentrations of 62.5, 125, 250, and 500 µg/mL using the DPPH scavenging assay. Results: Results revealed that both the hexane, ethyl-acetate, and aqueous fractions exhibited hypoglycemic and antioxidants activities in a dose-dependent manner. The n-hexane fraction demonstrated highest percentage DPPH scavenging effect of 26.34±3.43, 38.44±4.35, 59.34±3.45, and 74.83±5.35 at 62.5, 125, 250, and 500 µg/mL respectively. The ethyl-acetate fraction demonstrated 19.33±2.98, 28.94±3.24, 47.34±2.90, and 57.82±4.54 respectively while the aqueous fraction exhibited the least activities of 12.45±23.45, 18.64±2.94, 27.94±3.89, and 39.43±3.89 at concentrations of 62.5, 125, 250, and 500 µg/mL respectively. In addition, the n-hexane fraction demonstrated the most significant hypoglycemic effect with the highest glucose reduction of 58.97 ±3.45 %, 63.86±5.35 %, and 66.51±4.35 %, ethyl acetate fraction demonstrated glucose reduction of 7.55±0.54%, 21.77±2.35 %, and 29.56±3.46 % while the aqueous fraction demonstrated the least hypoglycemic effect of 9.89±2.67 %, 18.09±3.45 %, and 18.87±3.24 at 100, 200 and 400 mg/kg bw respectively. Conclusion: The n-hexane fraction of Azanza garckeana extract could serve as a reservoir of bioactive agents that could be useful for the development of a new anti-diabetic agent

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Wei, Ying, Pengshou Li, Bo Li, Jiaqi Gao, Dongchao Wang, Lingling Qin, Wen Sun et al. „Study of the Hypoglycemic Activity of Derivatives of Isoflavones fromCicer arietinumL.“ Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–18. http://dx.doi.org/10.1155/2017/8746823.

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The chickpea, a food and medicine used by the people of Xinjiang, has a beneficial hypoglycemic effect. To better utilize this national resource and develop hypoglycemic agents from components of the chickpea, a series of new derivatives of isoflavone compounds from the chickpea were synthesized. An insulin-resistant (IR) HepG2 cell model was used to screen the hypoglycemic activities of these compounds. And the structure-activity relationships of these compounds were explored. Additionally, several combinations of these compound displayed higher hypoglycemic activity than any single compound, and they had similar hypoglycemic activity to that of the positive control group (p>0.05). In addition, combination 3 and combination 6 exerted different effects on the insulin sensitivity of H4IIE cells stimulated with resistin. And the results indicated that combination 3 would have higher hypoglycemic activity. These findings demonstrate the characteristics of multiple components and targets of Chinese herbal medicine. This evidence may provide new ideas for the development of hypoglycemic drugs.

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Chen, Juncheng, Lin Li, Xin Zhou, Pengyao Sun, Bing Li und Xia Zhang. „Preliminary characterization and antioxidant and hypoglycemic activities in vivo of polysaccharides from Huidouba“. Food & Function 9, Nr. 12 (2018): 6337–48. http://dx.doi.org/10.1039/c8fo01117f.

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Chang, Chia-Chuan, Wei Yuan, Yun-Lian Lin, Ren-Shyan Liu, Yi-Chen Juan, Wan-Hua Sun, Huey Jen Tsay, Hsiu-Chen Huang, Yu-Ching Lee und Hui-Kang Liu. „Evaluation of theIn VivoTherapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays“. Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3262790.

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Background. Radix Paeoniae Rubra (Chi Shao) contains several phytochemicals with hypoglycemic actions. Current research aims to explore potential insulinotropic effects and long-term therapeutic efficacy of such herb against type 2 diabetes.Methods. Composition analysis for the ethanol extract (PRExt) was executed by high performance liquid chromatography. Polyphenol-enriched fraction was characterized by high pressure size exclusion chromatography. Multiple cell platforms were employed to evaluate hypoglycemic bioactivities. In animal experiments, blood glucose, the homeostasis model assessment (HOMA)-index assessment, glucose tolerance test, andin vivoglucose uptake were all measured. Additional effects of PRExt on obesity and hepatic steatosis were evaluated by serum and histological analysis.Results. PRExt provides multiple hypoglycemic effects including the enhancement of glucose-mediated insulin secretion. Pentagalloylglucose and polyphenol-enriched fraction are two insulinotropic constituents. Moreover, PRExt intraperitoneal injection causes acute hypoglycemic effects on fasted db/db mice. Oral administration of PRExt (200 mg/kg b.w.) gradually reduces blood glucose in db/db mice to the level similar to that in C57J/B6 mice after 30 days. The improvement of glucose intolerance, HOMA-index, andin vivoglucose uptake is evident in addition to the weight loss effect and attenuation of hepatic steatosis.Conclusion. PRExt is an effective antidiabetic herbal extract with multiple hypoglycemic bioactivities.

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Loizzo, Monica R., Giuseppe Di Lecce, Emanuele Boselli, Marco Bonesi, Federica Menichini, Francesco Menichini und Natale Giuseppe Frega. „In vitroantioxidant and hypoglycemic activities of Ethiopian spice blendBerbere“. International Journal of Food Sciences and Nutrition 62, Nr. 7 (20.05.2011): 740–49. http://dx.doi.org/10.3109/09637486.2011.573470.

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Sharmin, Tasnuva, Farhana Islam, Md Al Amin Sikder, Shaila Kabir, Mohammad Rashedul Haque und Mohammad A. Rashid. „Membrane Stabilizing and Preliminary Hypoglycemic Activities of Picrasma javanica“. Bangladesh Pharmaceutical Journal 16, Nr. 1 (08.04.2013): 89–92. http://dx.doi.org/10.3329/bpj.v16i1.14500.

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The methanol extract of leaves of Picrasma javanica Blume and its n-hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were evaluated for membrane stabilizing and preliminary hypoglycemic activities. In hypotonic solution and heat-induced conditions, the crude methanol extract inhibited 65.30±0.52% and 36.79±0.38% haemolysis of RBC as compared to 72.79% and 42.12% produced by standard drug, acetyl salicylic acid, respectively (0.10 mg/ml). The crude extract also showed blood sugar lowering efficacy at 200 and 400 mg/ kg body weight, with 48.63% reduction of blood sugar level at 400 mg/kg body weight while the standard drug, Glibenclamide (10 mg/kg body weight) demonstrated 53.7% reduction of blood sugar level at 3rd hour of administration. DOI: http://dx.doi.org/10.3329/bpj.v16i1.14500 Bangladesh Pharmaceutical Journal 16(1): 89-92, 2013

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Ogawa, Haruko, Yasuo Kunoh, Takao Sugiura und Mitsuaki Nagasaka. „Hypoglycemic activities of MTP-3631 a novel thiopyranopyrimidine derivative“. Life Sciences 50, Nr. 5 (Januar 1992): 375–81. http://dx.doi.org/10.1016/0024-3205(92)90439-v.

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Zhang, Ji-Quan, Shu-Min Li, Xiao Ma, Gang Zhong, Rui Chen, Xiao-Shuang Li, Gao-Feng Zhu et al. „Discovery of tetrahydrocarbazoles with potent hypoglycemic and hypolipemic activities“. European Journal of Medicinal Chemistry 150 (April 2018): 102–12. http://dx.doi.org/10.1016/j.ejmech.2018.02.069.

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Sultana, Nahid, Mahfuza Afroz Soma und Md Abdur Rashid. „Analgesic, Hypoglycemic and Antidiarrheal Activities Screening of Canna indica L.“ Bangladesh Pharmaceutical Journal 25, Nr. 2 (30.07.2022): 137–42. http://dx.doi.org/10.3329/bpj.v25i2.60965.

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The rhizome of Canna indica L. (family: Cannaceae) was extracted in methanol and two doses- 200 and 400 mg/kg body weight of the extract were employed to reveal central and peripheral analgesic, hypoglycemic and antidiarrheal properties in vivo. According to tail immersion technique, both doses significantly rose the time of latent response for 90 minutes compared to control mice group in assessing central analgesia. Acetic acid-induced writhing process demonstrated 37.29% and 64.41% inhibition of mice movement at both doses, respectively which indicated promising and statistically significant peripheral analgesic effect. On the other hand, hypoglycemic and antidiarrheal activities maintained dose and time dependent manner. Moreover, the extract of rhizome displayed statistically significant antidiarrheal activity at 400 mg/kg b.w. dose. Bangladesh Pharmaceutical Journal 25(2): 137-142, 2022 (July)

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Sultana, Nahid, Mahfuza Afroz Soma und Md Abdur Rashid. „Analgesic, Hypoglycemic and Antidiarrheal Activities Screening of Canna indica L.“ Bangladesh Pharmaceutical Journal 25, Nr. 2 (30.07.2022): 137–42. http://dx.doi.org/10.3329/bpj.v25i2.60965.

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The rhizome of Canna indica L. (family: Cannaceae) was extracted in methanol and two doses- 200 and 400 mg/kg body weight of the extract were employed to reveal central and peripheral analgesic, hypoglycemic and antidiarrheal properties in vivo. According to tail immersion technique, both doses significantly rose the time of latent response for 90 minutes compared to control mice group in assessing central analgesia. Acetic acid-induced writhing process demonstrated 37.29% and 64.41% inhibition of mice movement at both doses, respectively which indicated promising and statistically significant peripheral analgesic effect. On the other hand, hypoglycemic and antidiarrheal activities maintained dose and time dependent manner. Moreover, the extract of rhizome displayed statistically significant antidiarrheal activity at 400 mg/kg b.w. dose. Bangladesh Pharmaceutical Journal 25(2): 137-142, 2022 (July)

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Ndile, Michael Musila, Wycliffe Arika Makori, Cromwell Mwiti Kibiti und Mathew Piero Ngugi. „In Vitro Hypoglycemic and Antioxidant Activities of Dichloromethane Extract of Xerophyta spekei“. Scientifica 2023 (29.12.2023): 1–16. http://dx.doi.org/10.1155/2023/6652112.

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Diabetes mellitus is a chronic metabolic disorder which has greatly led to an increase in morbidity and mortality globally. Although Xerophyta spekei is widely used for the management of diabetes among the Embu and Mbeere communities in Kenya, it has never been empirically evaluated for its hypoglycemic activity. This study was carried out to verify the hypoglycemic activity of dichloromethane (DCM) extract of Xerophyta spekei as well as its antioxidant activity using various in vitro techniques. Phytochemicals associated with its antioxidant activity were identified through GC-MS. Data were subjected to descriptive statistics and expressed as mean ± standard error of the mean (X̄ ± SEM). Comparison between various variables was performed by using unpaired Student’s t-test and one-way analysis of variance (ANOVA), followed by Tukey’s post-hoc test. The confidence interval was set at 95%. The obtained results were presented in tables and graphs. Results showed that there was no difference in α-amylase inhibition activity between the plant extract and the standard (IC50 525.9 ± 12.34 and 475.1 ± 9.115, respectively; p > 0.05). Besides, the glucose adsorption activity of the extract increased with an increase in glucose concentration (from 5.89 to 32.64 mg/dl at 5 mmol and 30 mmol of glucose, respectively; p < 0.05). The extract also limited the diffusion of glucose more than the negative control (7.49 and 17.63 mg/dl, respectively; p < 0.05). It also enhanced glucose uptake by yeast cells. In addition, the studied plant extract showed notable antioxidant activities. The therapeutic effects exhibited by this plant in managing diabetes mellitus and other ailments could be due to its antioxidant as well as its hypoglycemic activity. The study recommends the evaluation of X. spekei for in vivo hypoglycemic and antioxidant activities. Besides, the isolation of bioactive phytochemicals from the plant may lead to the development of new hypoglycaemic agents.

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Chauhan, Beenu Singh, Albha Tiwari und Arti Bhadauria. „A study on dislipidemic and hyper glycemic activities of Aloe vera“. INTERNATIONAL JOURNAL OF AGRICULTURAL SCIENCES 19, Nr. 1 (15.01.2023): 115–21. http://dx.doi.org/10.15740/has/ijas/19.1/115-121.

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Aloe, a popular plant, has a long history as a versatile folk remedy. The plant can be alienated mainly into two products: gel and latex. Aloe vera gel is the leaf pulp or mucilage, aloe latex, commonly referred to as “aloe juice,” is a bitter yellow exudate from the pericyclic tubules just underneath the external skin of the leaves. Extracts of aloe gum efficiently improves glucose tolerance in diabetic rats as well as in normal rats. Treatment of long term however not solitary dose of exudates of Aloe barbadensis leaves impart hypoglycemia in alloxanized diabetic rats. Solitary as well as long term doses of acrimonious component of the same plant also displayed hypoglycemic effect in diabetic rats. This response of Aloe vera and its acrimonious component is by the stimulus of synthesis and/or release of insulin from pancreatic beta cells. Aloe vera also have got the anti-inflammatory potential in a dose reliant way and relieves wound in diabetic mice by healing activity. The current article highlights the biological activities of Aloe Vera.

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Cardell, Monika, Bo K. Siesjö und Tadeusz Wieloch. „Changes in Pyruvate Dehydrogenase Complex Activity during and following Severe Insulin-Induced Hypoglycemia“. Journal of Cerebral Blood Flow & Metabolism 11, Nr. 1 (Januar 1991): 122–28. http://dx.doi.org/10.1038/jcbfm.1991.14.

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The effect of severe insulin-induced hypoglycemia on the activity of the pyruvate dehydrogenase enzyme complex (PDHC) was investigated in homogenates of frozen rat cerebral cortex during burst suppression EEG, after 10, 30, and 60 min of isoelectric EEG, and after 30 and 180 min and 24 h of recovery following 30 min of hypoglycemic coma. Changes in PDHC activity were correlated to levels of labile organic phosphates and glycolytic metabolites. In cortex from control animals, the rate of [1-14C]pyruvate decarboxylation was 7.1 ± 1.3 U/mg of protein, or 35% of the total PDHC activity. The activity was unchanged during burst suppression EEG whereas the active fraction increased to 81–87% during hypoglycemic coma. Thirty minutes after glucose-induced recovery, the PDHC activity had decreased by 33% compared to control levels, and remained significantly depressed after 3 h of recovery. This decrease in activity was not due to a decrease in the total PDHC activity. At 24 h of recovery, PDHC activity had returned to control levels. We conclude that the activation of PDHC during hypoglycemic coma is probably the result of an increased PDH phosphatase activity following depolarization and calcium influx, and allosteric inhibition of PDH kinase due to increased ADP/ATP ratio. The depression of PDHC activity following hypoglycemic coma is probably due to an increased phosphorylation of the enzyme, as a consequence of an imbalance between PDH phosphatase and kinase activities. Since some reduction of the ATP/ADP ratio persisted and since the lactate/pyruvate ratio had normalized by 3 h of recovery, the depression of PDHC most likely reflects a decrease in PDH phosphatase activity, probably due to a decrease in intramitochondrial Ca2+.

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Tu, Lanlan, Rui Wang, Zheng Fang, Mengge Sun, Xiaohui Sun, Jinhong Wu, Yali Dang und Jianhua Liu. „Assessment of the Hypoglycemic and Hypolipidemic Activity of Flavonoid-Rich Extract from Angelica keiskei“. Molecules 27, Nr. 19 (06.10.2022): 6625. http://dx.doi.org/10.3390/molecules27196625.

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Angelica keiskei contains a variety of bioactive compounds including chalcone, coumarin, and phytochemicals, endowing it with pharmacological effects such as lipid-lowering activity, antitumor activity, liver protection, and nerve protection. This study aims to study the hypoglycemic and hypolipidemic effects of the flavonoid-rich extract from Angelica keiskei (FEAK) in an effort to exploit new applications of FEAK and increase its commercial value. In this paper, flavonoid compounds in Angelica keiskei were extracted using 50% ethanol, and the contents of the flavonoid compounds were analyzed by UPLC-MS/MS. Then, the hypoglycemic and hypolipidemic activities of the FEAK were investigated through in vitro enzyme activity and cell experiments as well as establishing in vivo zebrafish and Caenorhabditis elegans (C. elegans) models. The UPLC-MS/MS results show that the major flavonoid compounds in the FEAK were aureusidin, xanthoangelol, kaempferol, luteolin, and quercetin. The inhibitory rates of the FEAK on the activity of α-amylase and cholesterol esterase were 57.13% and 72.11%, respectively. In cell lipid-lowering experiments, the FEAK significantly reduced the total cholesterol (TC) and total triglyceride (TG) levels in a dose-dependent manner, with 150 μg/mL of FEAK decreasing the intracellular levels of TC and TG by 33.86% and 27.89%, respectively. The fluorescence intensity of the FEAK group was 68.12% higher than that of the control group, indicating that the FEAK exhibited hypoglycemic effects. When the concentration of the FEAK reached 500 μg/mL, the hypoglycemic effect on zebrafish reached up to 57.7%, and the average fluorescence intensity of C. elegans in the FEAK group was 17% lower than that of the control group. The results indicate that the FEAK had hypoglycemic and hypolipidemic activities. The findings of this study provide theoretical references for the high-value utilization of Angelica keiskei and the development of natural functional food with hypoglycemic and hypolipidemic activities.

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Won, GaYeong, Soo-Im Choi, NaYeong Park, Ji-Eun Kim, Chang-Ho Kang und Gun-Hee Kim. „In Vitro Antidiabetic, Antioxidant Activity, and Probiotic Activities of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Strains“. Current Microbiology 78, Nr. 8 (02.07.2021): 3181–91. http://dx.doi.org/10.1007/s00284-021-02588-5.

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AbstractDiabetes, a chronic metabolic disorder, is characterized by persistent hyperglycemia. This study aimed to evaluate the hypoglycemic and antioxidant activities of lactic acid bacteria strains isolated from humans and food products and investigate the probiotic properties of the selected four strains. The hypoglycemic activity of the isolated strains was examined by evaluating the α-glucosidase and α-amylase inhibitory activities. The antioxidant activity was measured using the DPPH, ABTS, and FRAP assays. Four strains (Lactiplantibacillus plantarum MG4229, MG4296, MG5025, and Lacticaseibacillus paracasei MG5012) exhibited potent α-glucosidase inhibitory (>75%) and α-amylase inhibitory (>85%) activities, which were comparable to those of acarbose (>50%; 1000 μg/mL). Similarly, the radical scavenging and antioxidant activities of the four strains were comparable to those of ascorbic acid (50 μg/mL). Additionally, the probiotic properties of the four selected strains were examined based on acid and bile salt tolerance, auto-aggregation ability, and antibiotic resistance. The four strains were resistant to pH 2 (>50% of survivability) and 0.5% bile salt (>80% of survivability). Therefore, we suggest that the selected strains with hypoglycemic, antioxidant, probiotic properties can potentially prevent diabetes.

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Li, Maoru, Guoyong Xie, Yadong Ding, Ji Ma, Qiuyan Liu, Yuqin Wang, Zan Peng, Jianbo Sun und Jing Shang. „Chemometric Discrimination of Cichorium glandulosum Boiss. et Huet and Cichorium intybus L. via Their Metabolic Profiling, Antioxidative, and Hypoglycemic Activities“. Foods 12, Nr. 4 (20.02.2023): 901. http://dx.doi.org/10.3390/foods12040901.

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Cichorium glandulosum Boiss. et Huet (CG) and Cichorium intybus L. (CI) are widely used as the main raw material of functional food with hepatoprotective and hypoglycemic effects. Due to the lack of comparison on the chemical ingredients and efficacy, they were often used imprecisely and interchangeably. It is necessary to distinguish between them. With the plant metabolomics based on high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS) and multivariate chemometric techniques, the chemical ingredients were characterized and 59 compounds between CG and CI were classified. As for antioxidative and hypoglycemic activities in vitro, CI extraction exhibited better antioxidant activity than CG, while CG extraction showed stronger hypoglycemic activity. Furthermore, a bivariate correlation between the chemical composition and efficacy of the extract was also analyzed, and three differentially strong correlation components between CI and CG were prepared, and the antioxidative and hypoglycemic efficacies were compared in vivo and different active phenotypes were obtained. Finally, we revealed chemical and biological differences between CG and CI, providing a basis for achieving better quality control and developing more effective functional foods.

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Chen, Chun, Li-Jun You, Arshad Mehmood Abbasi, Xiong Fu, Rui Hai Liu und Chao Li. „Characterization of polysaccharide fractions in mulberry fruit and assessment of their antioxidant and hypoglycemic activities in vitro“. Food & Function 7, Nr. 1 (2016): 530–39. http://dx.doi.org/10.1039/c5fo01114k.

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Zhang, Fengpei, Hui Xu, Yuan Yuan, Haichen Huang, Xiaoping Wu, Junli Zhang und Junsheng Fu. „Lyophyllum decastes fruiting body polysaccharide alleviates acute liver injury by activating the Nrf2 signaling pathway“. Food & Function 13, Nr. 4 (2022): 2057–67. http://dx.doi.org/10.1039/d1fo01701b.

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Liu, Jun-ping, Yan-fang Qian, Gao-yi-xin Qin, Li-yan Zhao und Gui-tang Chen. „Antidiabetic activities of glycoprotein from pea (Pisum sativum L.) in STZ-induced diabetic mice“. Food & Function 12, Nr. 11 (2021): 5087–95. http://dx.doi.org/10.1039/d1fo00535a.

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Han, Binkai, Dou Niu, Ting Wang, Shujing An, Yanzhen Wang, Xue Chen, Huailong Bi, Xiaochang Xue und Jiefang Kang. „Ultrasonic–microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice“. Food & Function 11, Nr. 12 (2020): 10709–23. http://dx.doi.org/10.1039/d0fo02568b.

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Pinkey, A. A. H., Z. I. Khan, M. A. Taher und M. A. Soma. „ELAEOCARPUS SERRATUS L. EXHIBITS POTENTIAL ANALGESIC AND ANTIDIARRHEAL ACTIVITIES IN MICE MODEL“. International Journal of Medicine and Medical Research 6, Nr. 2 (18.05.2021): 44–51. http://dx.doi.org/10.11603/ijmmr.2413-6077.2020.2.11388.

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Background. Elaeocarpus serratus L. (Family: Elaeocarpaceae) is a tropical fruit tree, traditionally used in the treatments of poisoning, diarrhea, arthritis, and other diseases. Objectives. The current study was performed to conduct the analgesic, antidiarrheal, and hypoglycemic activity of E. serratus in mice model using methanolic bark crude extract. Methods. To assess the peripheral and central analgesic activity, the acetic acid-induced writhing and tail immersion methods were respectively used. The castor-oil mediated antidiarrheal method was used to assess the antidiarrheal activity whereas, the tail tipping technique was conducted to determine the hypoglycemic activity of the plant extract. Results. In the peripheral analgesic assay, the methanolic bark crude extract of E. serratus significantly inhibits the number of writing 69.77% (200 mg/kg) and 73.26% (400 mg/kg) respectively (p<0.05) which was strongly comparable with standard NSAID drug diclofenac sodium 75.58% (p<0.05). Similarly, it shown a significant tail flicking response for 30 minutes, 60 minutes and 90 minutes of central analgesic activity assay. In antidiarrheal activity assay, the E. serratus substantially reduced the number of diarrheal feces 64.26% (200 mg/kg, p<0.05) and 78.57% (400 mg/kg, p<0.05) which was also comparable with the positive control loperamide. The hypoglycemic activity of E. serratus extract was not convincing. Conclusions. Our investigation demonstrated the significant analgesic and antidiarrheal activities of methanolic bark extract of E. serratus (200 and 400 mg/kg) in mice model.

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Yu, Rongxuan, Jianming Luo, Liu Liu und Xichun Peng. „Hypoglycemic Effect of Edible Fungi Polysaccharides Depends on Their Metabolites from the Fermentation of Human Fecal Microbiota“. Foods 13, Nr. 1 (27.12.2023): 97. http://dx.doi.org/10.3390/foods13010097.

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Edible fungi polysaccharides are widely sourced and have various physiological activities, including hypoglycemic. Current studies mainly focus on the hypoglycemic activity of polysaccharides themselves, while the strength of the hypoglycemic activity of edible fungi polysaccharides from different sources remained elusive. This study compared the hypoglycemic activity of different edible fungi polysaccharides after in vitro fermentation by fecal bacteria, combined with non-targeted metabolomics and 16S rDNA analysis, to screen out potential key metabolites related to the hypoglycemic activity. The results show that the fermentation supernatants of all four edible fungi polysaccharides significantly increased the glucose consumption and glycogen synthesis of IR-HepG2, also up-regulated the level of hexokinase and down-regulated the level of phosphoenolpyruvate carboxylase. All fermentation supernatants could alleviate the insulin resistance of IR-HepG2 cells by regulating the expression levels of genes related to the IRS-1/PI3K/Akt signaling pathway. Gingerglycolipid A, sphinganine 1-phosphate, matricin, tricarballylic acid, N-carbamoylputrescine, nomega-acetylhistamine, tyramine, and benzamide could be considered as potential key metabolites to evaluate the hypoglycemic effects. Their levels were strongly positively correlated with the abundance of Candidatus_Stoquefichu, Faecalibacterium, Coprococcus, Bacteroides, Eubacterium_ventriosum_group, Anaerostipes, Parabacteroides, and Agathobacter. These metabolites and microorganisms are closely related to the hypoglycemic activity of edible fungi polysaccharides.

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Wang, H. X., und T. B. Ng. „Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities“. Life Sciences 65, Nr. 25 (November 1999): 2663–77. http://dx.doi.org/10.1016/s0024-3205(99)00253-2.

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Min, Kyung Hoon, So Young Baek, Ra Ok Jeon, Hyun Ju Park, Won Ki Kim, Seung Hoon Cheon und Young Ger Suh. „Design and hypoglycemic activities of 2-alkylglycidate possessing aryloxyalkyl residue“. Archives of Pharmacal Research 22, Nr. 6 (Dezember 1999): 646–47. http://dx.doi.org/10.1007/bf02975341.

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Wanniarachchi, Kasuni K., L. Dinithi C. Peiris und W. D. Ratnasooriya. „Antihyperglycemic and hypoglycemic activities ofPhyllanthus debilisaqueous plant extract in mice“. Pharmaceutical Biology 47, Nr. 3 (März 2009): 260–65. http://dx.doi.org/10.1080/13880200802435754.

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Zhang, Le, Qiang Wang, Yayun Zhao, Juan Ge und Dajun He. „Phenolic Profiles, Antioxidant, and Hypoglycemic Activities of Ribes meyeri Fruits“. Foods 12, Nr. 12 (18.06.2023): 2406. http://dx.doi.org/10.3390/foods12122406.

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Ribes meyeri is a Ribes genus in the Saxifragaceae family, which is used as both medicine and food. However, the active components and biological activities of R. meyeri fruits are still unknown. In this paper, the phenolic components and their antioxidant and hypoglycemic activities of R. meyeri fruits were studied. Firstly, a total of 42 phenolic components of R. meyeri fruits, including 26 anthocyanins, 9 flavonoids, and 7 phenolic acids, were tentatively identified using HPLC-QTOF-MS/MS, and the main four anthocyanins were quantified using UPLC-MS/MS. The result indicated that cyanidin-3-O-rutinoside is the main anthocyanin in the R. meyeri fruits. The anthocyanin fraction of R. meyeri fruits exhibited significant inhibitory activity on α-amylase and α-glucosidase. The anthocyanin fraction from R. meyeri fruits significantly increased the glucose uptake of 3T3-L1 adipocytes. This is the first study of a qualitative and quantitative analysis of the phenolics of R. meyeri fruits.

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Verma, Mukesh, Baljeet Singh Saharan und Anil Kumar. „Contributions of probiotic L. acidophilus 291 as biotechnological tool in therapeutic applications“. Research Journal of Biotechnology 18, Nr. 9 (15.08.2023): 147–54. http://dx.doi.org/10.25303/1809rjbt1470154.

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The present study was carried out to evaluate the hypoglycemic ability and antioxidant activities of lactic acid bacterial strain L. acidophilus NCDC 291 and to investigate the probiotic characteristics of the strain as well as its suitability as an alternative antimutagenic agent. The antidiabetic activity was examined by evaluating the α-glucosidase and α-amylase inhibitory activities. Strain L. acidophilus NCDC 291 exhibited hypoglycemic ability by α-glucosidase (41.67 %) and α-amylase (61.79 %). Strain L. acidophilus NCDC 291 showed antioxidant activities by DPPH (53.58 % and IC50 67.87 μL) and ABTS (50.61 % and IC50 45.17 μL). Further the bacterial strain was resistant to simulated gastrointestinal juice and showed potential for health promotion based on adhesion, antibiotic susceptibility and antimicrobial activities. L. acidophilus NCDC 291 appears as potential probiotic with beneficial health effects.

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Mohapatra, L., S. K. Bhattamisra, R. C. Panigrahy und S. Parida. „EVALUATION OF ANTIOXIDANT, HYPOGLYCAEMIC, ANTIDIABETIC AND ALPHA AMYLASE INHIBITING ACTIVITIES OF SARGASSUM WIGHTII COLLECTED FROM THE EAST COAST OF INDIA“. INDIAN DRUGS 55, Nr. 01 (28.01.2018): 61–69. http://dx.doi.org/10.53879/id.55.01.10988.

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This study evaluated the antioxidant, hypoglycemic, antidiabetic and alpha amylase inhibiting activities of Sargassum wightii. Antioxidant activity of ethyl acetate and methanol extracts of this seaweed was evaluated and extract having promising antioxidant activity was further studied for hypoglycaemic and antidiabetic activity in normal and alloxan induced diabetic mice, respectively, at 100 and 200mg/ kg after toxicity evaluation. Ethyl acetate extract of S. wightii (EAS) has shown promising antioxidant, hypoglycemic and antidiabetic activity. Total phenol content for EAS was 250.09 ± 4.41mg/g. Fasting plasma glucose level in normal mice was significantly (p<0.05) decreased after 6 days of EAS (200mg/ kg) treatment. EAS at 100 and 200mg/kg has significantly (p<0.05) attenuated AUC of OGTT of diabetic mice. EAS was also found to have potent in vitro alpha-amylase inhibiting property. The current findings suggest that the anti-diabetic activity of S. wightii might be due to its underlying antioxidant, hypoglycemic and alpha-amylase inhibiting property.

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Liu, Hesheng, Xiangyang Qi, Keke Yu, Anjie Lu, Kaifeng Lin, Jiajing Zhu, Min Zhang und Zhida Sun. „AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice“. Food & Function 10, Nr. 1 (2019): 151–62. http://dx.doi.org/10.1039/c8fo01486h.

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Gnoumou, Edouard, Teeradate Kongpichitchoke und Ashika Jose. „Effect of Solid-State Fermentation (SSF) on the Antioxidant and Hypoglycemic Activities of Jackfruit (Artocarpus Heterophyllus Lam.) By-Products using Aspergillus Niger, Aspergillus Oryzae and Rhizopus Oryzae“. Trends in Sciences 20, Nr. 10 (20.08.2023): 5648. http://dx.doi.org/10.48048/tis.2023.5648.

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The objective of this experiment was to study the effect of Solid-State Fermentation (SSF) on jackfruit by-products using filamentous fungi. Rags from a ripen jackfruit were fermented for 5, 10 and 15 days by Aspergillus niger, Aspergillus oryzae and Rhizopus oryzae at 30 °C. Then the bioactive compounds were extracted using methanol. Total phenolic content, total flavonoid content, antioxidant activity and hypoglycemic activity of each liquid extract were estimated. The results showed significant increase and improvement in the samples in which SSF was applied. The highest total phenolic contents were found in fermented products with A. niger and R. oryzae with an average of 14.16 mg GAE/g D.S which was almost 3 times over the concentration found in unfermented products (4.83 mg GAE/g D.S). The same fermented products showed a significant increase in total flavonoid content which was 2 times higher than unfermented products with an average of 31.79 mg QuE/g D.S for fermented products and 15.08 for unfermented. The antioxidant activity was correlated to the total phenolic and flavonoid contents with the highest activity of around 76 % found in fermented products against 55 % for the unfermented ones. Finally, hypoglycemic activity was also found to be higher in fermented products than the unfermented with the best activity obtained in 5-days fermented product with A. oryzae (35.62 %) which was 8 times higher than non-fermented products (4.52 %). The present study showed that Solid-State Fermentation has a great potentiality to improve and enhance antioxidant and hypoglycemic activities of plant by-products. HIGHLIGHTS SSF improved the Antioxidant and hypoglycemic properties of jackfruit rags niger and R. oryzae had better capacity in improving the antioxidant activity Phenolic Content, Flavonoid Content and Antioxidant Activity were correlated Better hypoglycemic activity was seen in fermented products with oryzae oryzae could produce a new bioactive compound with high hypoglycemic activity GRAPHICAL ABSTRACT

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Yang, Chang, Qi Feng, Huan Liao, Xinlei Yu, Yang Liu und Di Wang. „Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice“. International Journal of Molecular Sciences 20, Nr. 20 (21.10.2019): 5205. http://dx.doi.org/10.3390/ijms20205205.

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Termitornyces albuminosus is a kind of traditional Chinese edible fungus rich in nutrients and medicinal ingredients, and it has anti-oxidative, analgesic and anti-inflammatory effects. However, the hypoglycemic and nephroprotective effects of polysaccharides separated from T. albuminosus (PTA) have not been reported. The properties of PTA were analyzed in a BKS.Cg-Dock7m +/+ Leprdb/JNju (db/db) mouse model of diabetes. After the administration of PTA for eight weeks, the hypoglycemic and hypolipidemic activities of PTA in the db/db mice were assessed. The results of a cytokine array combined with an enzyme-linked immunosorbent assay confirmed the anti-oxidative and anti-inflammatory activities of PTA. An eight-week administration of PTA caused hypoglycemic and hypolipidemic functioning, as indicated by suppressed plasma glucose levels, as well as the modulation of several cytokines related to glycometabolism, in the sera and kidneys of the mice. PTA treatment also had a protective effect on renal function, restoring renal structures and regulating potential indicators of nephropathy. In the kidneys of the db/db mice, PTA treatment reduced the activation of protein kinase B, the inhibitor of κB kinase alpha and beta, and the inhibitor of κB alpha and nuclear factor-κB (NF-κB). We establish the hypoglycemic, hypolipidemic, and anti-diabetic nephropathy effects of PTA, and we find that the renal protection effects of PTA may be related to anti-inflammatory activity via the regulation of NF-κB signaling.

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Yang, Rui, Yangdan Li, Jingjing Cai, Junqiu Ji, Ya Wang, Wenna Zhang, Wenjuan Pan und Yan Chen. „Polysaccharides from Armillariella tabescens mycelia ameliorate insulin resistance in type 2 diabetic mice“. Food & Function 11, Nr. 11 (2020): 9675–85. http://dx.doi.org/10.1039/d0fo00728e.

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Mahrosh, Hafiza Salaha, Rizwan Mehmood, Shazia Anwer Bukhari, Gulnaz Afzal und Rawaba Arif. „Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities“. BioMed Research International 2021 (09.03.2021): 1–8. http://dx.doi.org/10.1155/2021/5550180.

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Diabetes mellitus is the most common chronic disorder and leading cause of renal, neurological, and gastrointestinal manifestations in developed and developing countries. Despite of many drugs and combinational therapies, the complications of diabetes are still listed due to severe consequences of those drugs. In past few years, plant-derived drugs draw special attention due to their higher efficacy and fewer side-effects. Momordica charantia also known as bitter melon is referred as an antidiabetic and hypoglycemic plant in native populations of Asia and East Africa. In current study, an in silico approach was used to evaluate the interactions and binding patterns of plant-derived peptides devised from a hypoglycemic protein adMc1 of M. charantia as potential inhibitor of DPP-IV, SGLT1, and GLUT2 receptor proteins. The study has described a novel approach to investigate hypoglycemic peptides to cure diabetes. A total of eighty tetra-, penta-, and hexapeptides were devised from conserved regions of adMc1 homologs. The molecular docking approach using MOE software was employed to reveal inhibiting potentials of devised peptides against three selected proteins. Out of 30 shortlisted ligands six peptides (i.e. SMCG, DECC, TTIT, RTTI, ARNL and TVEV) accomplished the criteria of being good drug candidates against selected receptor proteins following the drugability assessment test. The overall results are acceptable on the basis of ADMET profiling for being good drug candidates against selected proteins.

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Chen, Hong, Zhuoyun Chen, Yuanfang Fu, Jiao Liu, Siying Lin, Qing Zhang, Yuntao Liu et al. „Structure, Antioxidant, and Hypoglycemic Activities of Arabinoxylans Extracted by Multiple Methods from Triticale“. Antioxidants 8, Nr. 12 (25.11.2019): 584. http://dx.doi.org/10.3390/antiox8120584.

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Different methods of isolating arabinoxylans (AXs) from triticale were performed to investigate the extraction methods’ effects on the physiological functions of the AXs. Structural, antioxidant, and hypoglycemic activities were determined. The molecular weights (MWs) of enzyme- or water-extracted AXs were lower than those of alkali-extracted AXs. Opposite trends were shown by the arabinose–xylose ratio. Enzyme-extracted AXs exhibited higher glucose adsorption capacity and hydroxyl radical-scavenging efficiency than alkali-extracted AXs. The α-amylase inhibition ability, DPPH radical-scavenging capacity, and metal-chelating activity of alkali-extracted AXs were higher than those of enzyme-extracted AXs. Water-extracted AXs had the highest glucose dialysis retardation index. In conclusion, extraction methods can influence the physiological function of AXs through their structural features. AXs with higher MWs and esterified ferulic acid (FA) levels had higher antioxidant ability, whereas AXs with higher solubility and free FA level exhibited higher hypoglycemic activity.

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