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Zeitschriftenartikel zum Thema „Hyaluronan brush“

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Autor: Grafiati

Veröffentlicht am 7. Juli 2024

Zuletzt aktualisiert am 7. Juli 2024

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Cappelli, Andrea, Marco Paolino, Giorgio Grisci, Vincenzo Razzano, Germano Giuliani, Alessandro Donati, Claudia Bonechi et al. „Hyaluronan-coated polybenzofulvene brushes as biomimetic materials“. Polymer Chemistry 7, Nr. 42 (2016): 6529–44. http://dx.doi.org/10.1039/c6py01644h.

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Faubel, Jessica L., Riddhi P. Patel, Wenbin Wei, Jennifer E. Curtis und Blair K. Brettmann. „Giant Hyaluronan Polymer Brushes Display Polyelectrolyte Brush Polymer Physics Behavior“. ACS Macro Letters 8, Nr. 10 (25.09.2019): 1323–27. http://dx.doi.org/10.1021/acsmacrolett.9b00530.

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Lee, G. M., B. Johnstone, K. Jacobson und B. Caterson. „The dynamic structure of the pericellular matrix on living cells.“ Journal of Cell Biology 123, Nr. 6 (15.12.1993): 1899–907. http://dx.doi.org/10.1083/jcb.123.6.1899.

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Although up to several microns thick, the pericellular matrix is an elusive structure due to its invisibility with phase contrast or DIC microscopy. This matrix, which is readily visualized by the exclusion of large particles such as fixed red blood cells is important in embryonic development and in maintenance of cartilage. While it is known that the pericellular matrix which surrounds chondrocytes and a variety of other cells consists primarily of proteoglycans and hyaluronan with the latter binding to cell surface receptors, the macromolecular organization is still speculative. The macromolecular organization previously could not be determined because of the collapse of the cell coat with conventional fixation and dehydration techniques. Until now, there has been no way to study the dynamic arrangement of hyaluronan with its aggregated proteoglycans on living cells. In this study, the arrangement and mobility of hyaluronan-aggrecan complexes were directly observed in the pericellular matrix of living cells isolated from bovine articular cartilage. The complexes were labeled with 30- to 40-nm colloidal gold conjugated to 5-D-4, an antibody to keratan sulfate, and visualized with video-enhanced light microscopy. From our observations of the motion of pericellular matrix macromolecules, we report that the chondrocyte pericellular matrix is a dynamic structure consisting of individual tethered molecular complexes which project outward from the cell surface. These complexes undergo restricted rotation or wobbling. When the cells were cultured with ascorbic acid, which promotes production of matrix components, the size of the cell coat and the position of the gold probes relative to the plasma membrane were not changed. However, the rapidity and extent of the tethered motion were reduced. Treatment with Streptomyces hyaluronidase removed the molecules that displayed the tethered motion. Addition of hyaluronan and aggrecan to hyaluronidase-treated cells yielded the same labeling pattern and tethered motion observed with native cell coats. To determine if aggrecan was responsible for the extended configuration of the complexes, only hyaluronan was added to the hyaluronidase-treated cells. The position and mobility of the hyaluronan was detected using biotinylated hyaluronan binding region (b-HABR) and gold streptavidin. The gold-labeled b-HABR was found only near the cell surface. Based on these observations, the hyaluronan-aggrecan complexes composing the cell coat are proposed to be extended in a brush-like configuration in an analogous manner to that previously described for high density, grafted polymers in good solvents.

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Chen, Xinyue, und Ralf P. Richter. „Effect of calcium ions and pH on the morphology and mechanical properties of hyaluronan brushes“. Interface Focus 9, Nr. 2 (15.02.2019): 20180061. http://dx.doi.org/10.1098/rsfs.2018.0061.

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Hyaluronan (HA) is a linear, regular polysaccharide that plays as a chief structural and functional component in peri- and extracellular matrices, thus contributing significantly to many basic cellular processes. To understand more comprehensively the response of the supramolecular organization of HA polymers to changes in their aqueous environment, we study the effects of Ca 2+ concentration and pH on the morphology and rigidity of films of end-grafted HA polymers on planar supports (HA brushes), as a well-defined in vitro model system of HA-rich matrices, by reflection interference contrast microscopy and quartz crystal microbalance. The thickness and softness of HA brushes decrease significantly with Ca 2+ concentration but do not change with pH, within the physiological ranges of these parameters. The effect of Ca 2+ on HA brush thickness is virtually identical to the effect of Na + at 10-fold higher concentrations. Moreover, the thickness and softness of HA brushes decrease appreciably upon HA protonation at pH less than 6. Effects of pH and calcium ions are fully reversible over large parameter ranges. These findings are relevant for understanding the supramolecular organization and dynamics of HA-rich matrices in biological systems and will also benefit the rational design of synthetic HA-rich materials with tailored properties.

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Attili, Seetharamaiah, Oleg V. Borisov und Ralf P. Richter. „Films of End-Grafted Hyaluronan Are a Prototype of a Brush of a Strongly Charged, Semiflexible Polyelectrolyte with Intrinsic Excluded Volume“. Biomacromolecules 13, Nr. 5 (25.04.2012): 1466–77. http://dx.doi.org/10.1021/bm3001759.

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Pitarresi, Giovanna, Calogero Fiorica, Mariano Licciardi, Fabio Salvatore Palumbo und Gaetano Giammona. „New hyaluronic acid based brush copolymers synthesized by atom transfer radical polymerization“. Carbohydrate Polymers 92, Nr. 2 (Februar 2013): 1054–63. http://dx.doi.org/10.1016/j.carbpol.2012.10.017.

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Paulsson, M., M. Mörgelin, H. Wiedemann, M. Beardmore-Gray, D. Dunham, T. Hardingham, D. Heinegård, R. Timpl und J. Engel. „Extended and globular protein domains in cartilage proteoglycans“. Biochemical Journal 245, Nr. 3 (01.08.1987): 763–72. http://dx.doi.org/10.1042/bj2450763.

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Electron microscopy after rotary shadowing and negative staining of the large chondroitin sulphate proteoglycan from rat chondrosarcoma, bovine nasal cartilage and pig laryngeal cartilage demonstrated a unique multidomain structure for the protein core. A main characteristic is a pair of globular domains (diameter 6-8 nm), one of which forms the N-terminal hyaluronate-binding region. They are connected by a 25 nm-long rod-like domain of limited flexibility. This segment is continued by a 280 nm-long polypeptide strand containing most chondroitin sulphate chains (average length 40 nm) in a brush-like array and is terminated by a small C-terminal globular domain. The core protein showed a variable extent of degradation, including the loss of the C-terminal globular domain and sections of variable length of the chondroitin sulphate-bearing strand. The high abundance (30-50%) of the C-terminal domain in some extracted proteoglycan preparations indicated that this structure is present in the cartilage matrix rather than being a precursor-specific segment. It may contain the hepatolectin-like segment deduced from cDNA sequences corresponding to the 3′-end of protein core mRNA [Doege, Fernandez, Hassell, Sasaki & Yamada (1986) J. Biol. Chem. 261, 8108-8111; Sai, Tanaka, Kosher & Tanzer (1986) Proc. Natl. Acad. Sci. 83, 5081-5085; Oldberg, Antonsson & Heinegård (1987) Biochem. J. 243, 255-259].

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Wang, Lingyun, Meihuan Chen, Xueguang Ran, Hao Tang und Derong Cao. „Sorafenib-Based Drug Delivery Systems: Applications and Perspectives“. Polymers 15, Nr. 12 (09.06.2023): 2638. http://dx.doi.org/10.3390/polym15122638.

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As a Food and Drug Administration (FDA)-approved molecular-targeted chemotherapeutic drug, sorafenib (SF) can inhibit angiogenesis and tumor cell proliferation, leading to improved patient overall survival of hepatocellular carcinoma (HCC). In addition, SF is an oral multikinase inhibitor as a single-agent therapy in renal cell carcinoma. However, the poor aqueous solubility, low bioavailability, unfavorable pharmacokinetic properties and undesirable side effects (anorexia, gastrointestinal bleeding, and severe skin toxicity, etc.) seriously limit its clinical application. To overcome these drawbacks, the entrapment of SF into nanocarriers by nanoformulations is an effective strategy, which delivers SF in a target tumor with decreased adverse effects and improved treatment efficacy. In this review, significant advances and design strategies of SF nanodelivery systems from 2012 to 2023 are summarized. The review is organized by type of carriers including natural biomacromolecule (lipid, chitosan, cyclodextrin, etc.); synthetic polymer (poly(lactic-co-glycolic acid), polyethyleneimine, brush copolymer, etc.); mesoporous silica; gold nanoparticles; and others. Co-delivery of SF and other active agents (glypican-3, hyaluronic acid, apolipoprotein peptide, folate, and superparamagnetic iron oxide nanoparticles) for targeted SF nanosystems and synergistic drug combinations are also highlighted. All these studies showed promising results for targeted treatment of HCC and other cancers by SF-based nanomedicines. The outlook, challenges and future opportunities for the development of SF-based drug delivery are presented.

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Wei, Wenbin, Jessica L. Faubel, Hemaa Selvakumar, Daniel T. Kovari, Joanna Tsao, Felipe Rivas, Amar T. Mohabir et al. „Self-regenerating giant hyaluronan polymer brushes“. Nature Communications 10, Nr. 1 (Dezember 2019). http://dx.doi.org/10.1038/s41467-019-13440-7.

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AbstractTailoring interfaces with polymer brushes is a commonly used strategy to create functional materials for numerous applications. Existing methods are limited in brush thickness, the ability to generate high-density brushes of biopolymers, and the potential for regeneration. Here we introduce a scheme to synthesize ultra-thick regenerating hyaluronan polymer brushes using hyaluronan synthase. The platform provides a dynamic interface with tunable brush heights that extend up to 20 microns – two orders of magnitude thicker than standard brushes. The brushes are easily sculpted into micropatterned landscapes by photo-deactivation of the enzyme. Further, they provide a continuous source of megadalton hyaluronan or they can be covalently-stabilized to the surface. Stabilized brushes exhibit superb resistance to biofilms, yet are locally digested by fibroblasts. This brush technology provides opportunities in a range of arenas including regenerating tailorable biointerfaces for implants, wound healing or lubrication as well as fundamental studies of the glycocalyx and polymer physics.

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Carvalho, Ana M., Jesus Valcarcel, Diana Soares da Costa, Marisa Gomes, José Antonio Vázquez, Rui L. Reis, Ramon Novoa-Carballal und Iva Pashkuleva. „Hyaluronan Brush-like Copolymers Promote CD44 Declustering in Breast Cancer Cells“. ACS Applied Materials & Interfaces, 02.09.2022. http://dx.doi.org/10.1021/acsami.2c11864.

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Li, Ren, Xie Renjian, Yao Hang, Liu Sa und Shi Xuetao. „A novel bottle-brush polyelectrolyte based on hyaluronan and its application in bionic lubrication“. Frontiers in Bioengineering and Biotechnology 4 (2016). http://dx.doi.org/10.3389/conf.fbioe.2016.01.00406.

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Liu, Guoqiang, Yang Feng, Xiaohua Gao, Zhuo Chen, Nan Zhao, Feng Zhou und Weimin Liu. „Synovial fluid-inspired biomimetic lubricating microspheres: Zwitterionic polyelectrolyte brushes-grafted microgels“. Friction, 15.08.2022. http://dx.doi.org/10.1007/s40544-022-0634-5.

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AbstractSynovial fluid is made up of various biomacromolecules, including hyaluronic acid, aggrecans, lubricins, and phosphatidylcholine lipid, which are assembled onto the surface of articular cartilage in a gel state. Among them, brush-like biomacromolecules or assemblies have a vital effect on human joint lubrication. Inspired by this, the combination of brush-like molecular structures and gel-like assembly may be an efficient approach for the synthesis of biomimetic lubricating matters. Learning from the lubrication system of human joints, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) brushes grafted poly(N-isopropylacrylamide-co-acrylic acid) (poly(NIPAAm-co-AA)) microgels, abbreviated as MBs-g-MGs, were synthesized as one kind of biomimetic lubricating additives. It is worth noting that this bionic strategy considered both molecular structure and assembled form, which enabled this hairy microgel to achieve low friction in aqueous medium. Meanwhile, the effective lubrication was still achieved when using MBs-g-MGs at high temperature, indicating that this microgel maintains a good lubricating effect over a wide range of temperature. In addition, this kind of microgel possessed good biocompatibility, which laid the foundation for potential biomedical applications. Looking beyond, these biomimetic microgels may provide an effective lubricating effect for water-based sliding interfaces, especially in biomedical systems.

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Fan, Xiaopeng, Renjian Xie, Wenjing Song, Kunfu Ouyang und Li Ren. „Biomimetic Hyaluronic Acid-Based Brush Polymers Modulate Chondrocyte Homeostasis via ROS/Ca²⁺/TRPV4“. Biomacromolecules, 16.08.2023. http://dx.doi.org/10.1021/acs.biomac.3c00547.

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Zhong, Xiupeng, Gangyuan Bi, Hai Yang, Ying Liu, Qi Zhao, Wenjing Song, Sa Liu, Renjian Xie und Li Ren. „Biomimetic Pericellular Microniche Inspired by Chondron enhances the Cartilage Matrix Accumulation“. Macromolecular Chemistry and Physics, 02.08.2023. http://dx.doi.org/10.1002/macp.202300136.

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AbstractCartilage repair is currently an inevitable and significant issue due to the prevalence of cartilage defects or osteoarthritis. However, it remains a big challenge worldwide because of the avascular and aneural nature of cartilage. In this paper, a novel biomimetic pericellular microniche (BPM), inspired by chondron composed of chondrocyte and its surrounding pericellular matrix (PCM), is proposed to offer a promising solution to achieve cartilage repair. BPM, with a diameter ≈64 µm, not only mimicked the structure of the chondron but also mimicked the key components of the PCM by artificially synthesizing brush‐like molecules (HA/PA and HA/PM). Chondrocyte‐laden BPM is constructed successfully through microfluidic and showed excellent injectability. The encapsulated chondrocyte showed high viability in BPM. F‐Actin and H&E reflected that chondrocytes would grow out of BPM and adhere to the BPM surface through the interaction between CD44 and hyaluronic acid. RT‐qPCR and immunofluorescence staining indicated that the gene expression of type II collagen and aggrecan are upregulated significantly in the BPM. Therefore, the construction of BPM provides a promising strategy for cartilage tissue engineering.This article is protected by copyright. All rights reserved

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Susilo, Raden Joko Kuncoroningrat, Dwi Winarni, Suhailah Hayaza, Ruey-An Doong, Sri Puji Astuti Wahyuningsih und Win Darmanto. „Effect of crude Ganoderma applanatum polysaccharides as a renoprotective agent against carbon tetrachloride-induced early kidney fibrosis in mice“. Veterinary World, 23.04.2022, 1022–30. http://dx.doi.org/10.14202/vetworld.2022.1022-1030.

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Background and Aim: Interstitial fibrosis is the final stage of chronic kidney injury, which begins with an inflammatory process. Crude Ganoderma applanatum polysaccharides are known to have anti-inflammatory properties. The potential role of crude G. applanatum polysaccharides in renal fibrosis through pro-inflammatory cytokines needs further investigation. This study aimed to determine the renoprotective effect of crude G. applanatum polysaccharide extract in mice with carbon tetrachloride (CCL4)-induced early kidney fibrosis. Materials and Methods: This study was conducted for 4 weeks using 24 male BALB/c mice selected for their metabolic stability. The mice were randomly divided into six groups, including control (CG), model (MG), silymarin group and crude G. applanatum polysaccharide extract groups comprising doses of 25, 50, and 100 mg/kg body weight. After sacrificing the mice, whole blood was analyzed for urea and creatine levels, and kidney tissue was prepared to assess tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), hyaluronic acid (HA), and laminin levels, both using enzyme-linked immunosorbent assay. Kidney histology was determined using hematoxylin and eosin staining, while the extracellular matrix (ECM) components were stained using Masson's trichome staining. The α-smooth muscle actin (α-SMA) concentration was determined using immunohistochemistry. These parameters were measured to determine the effectiveness of the crude G. applanatum polysaccharide extract in preventing interstitial fibrosis. Results: Administration of crude G. applanatum polysaccharides effectively prevented increases in kidney weight and physiological enzymes, pro-inflammatory cytokines, and ECM production compared with those in the MG, as evidenced by the low levels of urea, creatinine, TNF-α, IL-6, HA, and laminin. Histopathological results also showed that crude G. applanatum polysaccharides prevented the occurrence of inflammatory infiltration, desquamated nuclei, cytoplasm debris, rupture at the brush border, dilatation of the glomeruli space and lumen of the proximal tubule, and necrotic cells compared with the MG. Masson's trichrome staining revealed lower collagen levels in the interstitial tubules of kidney tissue than those in the MG. Immunohistochemical analysis revealed low α-SMA expression in the crude G. applanatum polysaccharides treatment groups than that in the MG. Conclusion: The crude polysaccharide extract of G. applanatum has a protective effect that prevents the progression of kidney fibrosis in mice.

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