Zeitschriftenartikel: „Human neurogenesis“

1

Snyder, Jason S. „Questioning human neurogenesis“. Nature 555, Nr. 7696 (März 2018): 315–16. http://dx.doi.org/10.1038/d41586-018-02629-3.

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Murrell, Wayne, Gillian R. Bushell, Jonathon Livesey, John McGrath, Kelli P. A. MacDonald, Paul R. Bates und Alan Mackay-Sim. „Neurogenesis in adult human“. NeuroReport 7, Nr. 6 (April 1996): 1189–94. http://dx.doi.org/10.1097/00001756-199604260-00019.

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3

Sugano, Hidenori, Madoka Nakajima, Ikuko Ogino und Hajime Arai. „Neurogenesis in Human Epileptic Hippocampus“. Journal of the Japan Epilepsy Society 26, Nr. 1 (2008): 16–25. http://dx.doi.org/10.3805/jjes.26.16.

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4

Flor-García, Miguel, Julia Terreros-Roncal, Elena P. Moreno-Jiménez, Jesús Ávila, Alberto Rábano und María Llorens-Martín. „Unraveling human adult hippocampal neurogenesis“. Nature Protocols 15, Nr. 2 (08.01.2020): 668–93. http://dx.doi.org/10.1038/s41596-019-0267-y.

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5

Lucassen, Paul J., Nicolas Toni, Gerd Kempermann, Jonas Frisen, Fred H. Gage und Dick F. Swaab. „Limits to human neurogenesis—really?“ Molecular Psychiatry 25, Nr. 10 (07.01.2019): 2207–9. http://dx.doi.org/10.1038/s41380-018-0337-5.

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6

Liu, He, und Ni Song. „Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases“. Journal of Central Nervous System Disease 8 (Januar 2016): JCNSD.S32204. http://dx.doi.org/10.4137/jcnsd.s32204.

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Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood. This review article discusses molecular factors that affect adult neurogenesis, including morphogens, growth factors, neurotransmitters, transcription factors, and epigenetic factors. Furthermore, we summarize and compare current evidence of associations between adult neurogenesis and human brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and brain tumors.

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Inta, agos, und Peter Gass. „Is Forebrain Neurogenesis a Potential Repair Mechanism after Stroke?“ Journal of Cerebral Blood Flow & Metabolism 35, Nr. 7 (13.05.2015): 1220–21. http://dx.doi.org/10.1038/jcbfm.2015.95.

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The use of adult subventricular zone (SVZ) neurogenesis as brain repair strategy after stroke represents a hot topic in neurologic research. Recent radiocarbon-14 dating has revealed a lack of poststroke neurogenesis in the adult human neocortex; however, adult neurogenesis has been shown to occur, even under physiologic conditions, in the human striatum. Here, these results are contrasted with experimental poststroke neurogenesis in the murine brain. Both in humans and in rodents, the SVZ generates predominantly calretinin (CR)-expressing GABAergic interneurons, which cannot replace the broad spectrum of neuronal subtypes damaged by stroke. Therefore, SVZ neurogenesis may represent a repair mechanism only after genetic manipulation redirecting its differentiation.

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Mustafin, Rustam N., und Elza K. Khusnutdinova. „Postnatal neurogenesis in the human brain“. Morphology 159, Nr. 2 (01.08.2022): 37–46. http://dx.doi.org/10.17816/1026-3543-2021-159-2-37-46.

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Recently, a lot of data has been gathered which demonstrates neurogenesis in the brain of adult humans. In genetics, findings have been obtained that not only prove, but also elucidate the molecular mechanisms of neurogenesis. In some publications, however, morphology disputes neuronal renewal in adulthood. Therefore, this review presents the modern achievements of epigenetics, morphology, and physiology, which confirm and characterize postnatal neurogenesis in detail. We suggest that the introduction of molecular genetic technologies into morphological studies will be the starting point for the integration of these areas, complementing each other for the introduction of targeted therapy in clinical practice. Numerous evidence has been obtained of the presence of postnatal neurogenesis in adult humans in studies using bromodeoxyuridine, a carbon isotope of 14C, and 3H-thymidine, in comparative analyses of experimental data from animals. Neuronal stem cells, represented by radial glia present in the subventricular and subgranular zones of the human brain, are morphologically similar to neuroepithelial cells. They express marker proteins for astrocytes, which suggests that the proliferation of neuroglia found in adults can also indicate the regeneration of neurons. To prove this, further studies are required, with the exact identification of newly-formed cells, using specific molecular markers, and data from modern epigenetics. The integration of molecular genetic methods into morphology will facilitate not only the accurate determination of the classification of cells to a specific subpopulation but also to study the effects of various agents on the proliferation of neurons in the adult brain.

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Kessaris, Nicoletta. „Human cortical interneuron development unraveled“. Science 375, Nr. 6579 (28.01.2022): 383–84. http://dx.doi.org/10.1126/science.abn6333.

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10

Lewis, Sian. „Human olfaction is not neurogenesis-dependent“. Nature Reviews Neuroscience 13, Nr. 7 (20.06.2012): 451. http://dx.doi.org/10.1038/nrn3286.

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Eriksson, Peter S., Ekaterina Perfilieva, Thomas Björk-Eriksson, Ann-Marie Alborn, Claes Nordborg, Daniel A. Peterson und Fred H. Gage. „Neurogenesis in the adult human hippocampus“. Nature Medicine 4, Nr. 11 (November 1998): 1313–17. http://dx.doi.org/10.1038/3305.

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Palmos, Alish B., Rodrigo R. R. Duarte, Demelza M. Smeeth, Erin C. Hedges, Douglas F. Nixon, Sandrine Thuret und Timothy R. Powell. „Telomere length and human hippocampal neurogenesis“. Neuropsychopharmacology 45, Nr. 13 (13.09.2020): 2239–47. http://dx.doi.org/10.1038/s41386-020-00863-w.

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Abstract Short telomere length is a risk factor for age-related disease, but it is also associated with reduced hippocampal volumes, age-related cognitive decline and psychiatric disorder risk. The current study explored whether telomere shortening might have an influence on cognitive function and psychiatric disorder pathophysiology, via its hypothesised effects on adult hippocampal neurogenesis. We modelled telomere shortening in human hippocampal progenitor cells in vitro using a serial passaging protocol that mimics the end-replication problem. Serially passaged progenitors demonstrated shorter telomeres (P ≤ 0.05), and reduced rates of cell proliferation (P ≤ 0.001), with no changes in the ability of cells to differentiate into neurons or glia. RNA-sequencing and gene-set enrichment analyses revealed an effect of cell ageing on gene networks related to neurogenesis, telomere maintenance, cell senescence and cytokine production. Downregulated transcripts in our model showed a significant overlap with genes regulating cognitive function (P ≤ 1 × 10−5), and risk for schizophrenia (P ≤ 1 × 10−10) and bipolar disorder (P ≤ 0.005). Collectively, our results suggest that telomere shortening could represent a mechanism that moderates the proliferative capacity of human hippocampal progenitors, which may subsequently impact on human cognitive function and psychiatric disorder pathophysiology.

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Boldrini, Maura, Camille A. Fulmore, Alexandria N. Tartt, Laika R. Simeon, Ina Pavlova, Verica Poposka, Gorazd B. Rosoklija et al. „Human Hippocampal Neurogenesis Persists throughout Aging“. Cell Stem Cell 22, Nr. 4 (April 2018): 589–99. http://dx.doi.org/10.1016/j.stem.2018.03.015.

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Valeo, Tom. „Neurogenesis Demonstrated in Human Olfactory Bulb“. Neurology Today 7, Nr. 6 (März 2007): 34–35. http://dx.doi.org/10.1097/01.nt.0000266435.65543.bc.

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Shen, Jianfeng, Lin Xie, XiaoOu Mao, Yongqing Zhou, Renya Zhan, David A. Greenberg und Kunlin Jin. „Neurogenesis after Primary Intracerebral Hemorrhage in Adult Human Brain“. Journal of Cerebral Blood Flow & Metabolism 28, Nr. 8 (30.04.2008): 1460–68. http://dx.doi.org/10.1038/jcbfm.2008.37.

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Neurogenesis occurs in discrete regions of normal brains of adult mammals including humans, and is induced in response to brain injury and neurodegenerative disease. Whether intracerebral hemorrhage can also induce neurogenesis in human brain is unknown. Specimens were obtained from patients with primary intracerebral hemorrhage undergoing surgical evacuation of an intracerebral hematoma, and evaluated by two-photon laser scanning confocal microscopy. We found that neural stem/progenitor cell-specific protein markers were expressed in cells located in the perihematomal regions of the basal ganglia and parietal lobe of the adult human brain after primary intracerebral hemorrhage ( n = 5). Cells in this region also expressed cell proliferation markers, which colocalized to the same cells that expressed neural stem/progenitor cell-specific proteins. Our data suggest that intracerebral hemorrhage induces neurogenesis in the adult human brain.

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Estrada-Reyes, Rosa, Daniel B. Quero-Chávez, Salvador Alarcón-Elizalde, Montserrat G. Cercós, Citlali Trueta, Luis A. Constantino-Jonapa, Julián Oikawa-Sala et al. „Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors“. Molecules 27, Nr. 17 (01.09.2022): 5650. http://dx.doi.org/10.3390/molecules27175650.

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Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that the combination of MEL with ketamine (KET), an NMDA receptor antagonist, has robust antidepressant-like effects in mice, at doses that, by themselves, are non-effective and have no adverse effects. Here, we show that the KET/MEL combination increases neurogenesis in a clone derived from human olfactory neuronal precursors, a translational pre-clinical model for effects in the human CNS. Neurogenesis was assessed by the formation of cell clusters > 50 µm in diameter, positively stained for nestin, doublecortin, BrdU and Ki67, markers of progenitor cells, neurogenesis, and proliferation. FGF, EGF and BDNF growth factors increased the number of cell clusters in cultured, cloned ONPs. Similarly, KET or MEL increased the number of clusters in a dose-dependent manner. The KET/MEL combination further increased the formation of clusters, with a maximal effect obtained after a triple administration schedule. Our results show that the combination of KET/MEL, at subeffective doses that do not produce adverse effects, stimulate neurogenesis in human neuronal precursors. Moreover, the mechanism by which the combination elicits neurogenesis is meditated by melatonin receptors, CaM Kinase II and CaM antagonism. This could have clinical advantages for the fast treatment of depression.

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Stępień, Tomasz, Sylwia Tarka, Natalia Chmura, Michał Grzegorczyk, Albert Acewicz, Paulina Felczak und Teresa Wierzba-Bobrowicz. „Influence of SARS-CoV-2 on Adult Human Neurogenesis“. Cells 12, Nr. 2 (06.01.2023): 244. http://dx.doi.org/10.3390/cells12020244.

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Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with the onset of neurological and psychiatric symptoms during and after the acute phase of illness. Inflammation and hypoxia induced by SARS-CoV-2 affect brain regions essential for fine motor function, learning, memory, and emotional responses. The mechanisms of these central nervous system symptoms remain largely unknown. While looking for the causes of neurological deficits, we conducted a study on how SARS-CoV-2 affects neurogenesis. In this study, we compared a control group with a group of patients diagnosed with COVID-19. Analysis of the expression of neurogenesis markers showed a decrease in the density of neuronal progenitor cells and newborn neurons in the SARS-CoV-2 group. Analysis of COVID-19 patients revealed increased microglial activation compared with the control group. The unfavorable effect of the inflammatory process in the brain associated with COVID-19 disease increases the concentration of cytokines that negatively affect adult human neurogenesis.

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González-Martínez, Jorge A., William E. Bingaman, Steven A. Toms und Imad M. Najm. „Neurogenesis in the postnatal human epileptic brain“. Journal of Neurosurgery 107, Nr. 3 (September 2007): 628–35. http://dx.doi.org/10.3171/jns-07/09/0628.

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Object The normal adult human telencephalon does not reveal evidence of spontaneous neuronal migration and differentiation despite the robust germinal capacity of the subventricular zone (SVZ) astrocyte ribbon that contains neural stem cells. This might be because it is averse to accepting new neurons into an established neuronal network, probably representing an evolutionary acquisition to prevent the formation of anomalous neuronal circuits. Some forms of epilepsy, such as malformations of cortical development, are thought to be due to abnormal corticogenesis during the embryonic and early postnatal periods. The role of postnatal architectural reorganization and possibly postnatal neurogenesis in some forms of epilepsy in humans remains unknown. In this study the authors used resected specimens of epileptic brain to determine whether neurogenesis could occur in the diseased tissue. Methods The authors studied freshly resected brain tissue obtained in 47 patients who underwent neurosurgical procedures and four autopsies. Forty-four samples were harvested in patients who underwent resection for the treatment of pharmacoresistant epilepsy. Results Using organotypic brain slice preparations cultured with 5-bromodeoxyuridine (a marker for cell proliferation), immunohistochemistry, and cell trackers, the authors demonstrate the presence of spontaneous cell proliferation, migration, and neuronal differentiation in the adult human telencephalon that starts in the SVZ and progresses to the adjacent white matter and neocortex in human neocortical pathological structures associated with epilepsy. No cell migration or neuronal differentiation was found in the control group. Conclusions The presence of spontaneous neurogenesis associated with some forms of human neocortical epilepsy may represent an erroneous and maladaptive mechanism for neuronal circuitry repair, or it may be an intrinsic part of the pathogenic process.

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Gulati, Anil. „Understanding neurogenesis in the adult human brain“. Indian Journal of Pharmacology 47, Nr. 6 (2015): 583. http://dx.doi.org/10.4103/0253-7613.169598.

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Keenan, Thomas M., Aaron D. Nelson, Jeffrey R. Grinager, Jarett C. Thelen und Clive N. Svendsen. „Real Time Imaging of Human Progenitor Neurogenesis“. PLoS ONE 5, Nr. 10 (07.10.2010): e13187. http://dx.doi.org/10.1371/journal.pone.0013187.

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Lee, Hyunah, und Sandrine Thuret. „Adult Human Hippocampal Neurogenesis: Controversy and Evidence“. Trends in Molecular Medicine 24, Nr. 6 (Juni 2018): 521–22. http://dx.doi.org/10.1016/j.molmed.2018.04.002.

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Gandhi, Sonu, Jalaj Gupta und Prem Prakash Tripathi. „The Curious Case of Human Hippocampal Neurogenesis“. ACS Chemical Neuroscience 10, Nr. 3 (06.02.2019): 1131–32. http://dx.doi.org/10.1021/acschemneuro.9b00063.

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Gonzalez-Martinez, Jorge A., Gabriel Moddel, Imad M. Najm, Hans O. Lüders und William E. Bingaman. „712 Neurogenesis in Adult Human Neocortical Epilepsy“. Neurosurgery 55, Nr. 2 (01.08.2004): 456. http://dx.doi.org/10.1227/00006123-200408000-00048.

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Kempermann, Gerd, Fred H. Gage, Ludwig Aigner, Hongjun Song, Maurice A. Curtis, Sandrine Thuret, H. Georg Kuhn et al. „Human Adult Neurogenesis: Evidence and Remaining Questions“. Cell Stem Cell 23, Nr. 1 (Juli 2018): 25–30. http://dx.doi.org/10.1016/j.stem.2018.04.004.

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Berry, M. „Neurogenesis and gliogenesis in the human brain“. Food and Chemical Toxicology 24, Nr. 2 (Februar 1986): 79–89. http://dx.doi.org/10.1016/0278-6915(86)90341-8.

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Winner, Beate, D. Chichung Lie, Edward Rockenstein, Robert Aigner, Ludwig Aigner, Eliezer Masliah, H. Georg Kuhn und Jürgen Winkler. „Human Wild-Type α-Synuclein Impairs Neurogenesis“. Journal of Neuropathology & Experimental Neurology 63, Nr. 11 (November 2004): 1155–66. http://dx.doi.org/10.1093/jnen/63.11.1155.

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Kheirbek, Mazen A., und René Hen. „(Radio)active Neurogenesis in the Human Hippocampus“. Cell 153, Nr. 6 (Juni 2013): 1183–84. http://dx.doi.org/10.1016/j.cell.2013.05.033.

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Coplan, Jeremy D., Shariful Syed, Tarique D. Perera, Sasha L. Fulton, Mary Ann Banerji, Andrew J. Dwork und John G. Kral. „Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu“. Neural Plasticity 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/917981.

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Glucagon-like peptide-1 (GLP-1) regulates carbohydrate metabolism and promotes neurogenesis. We reported an inverse correlation between adult body mass and neurogenesis in nonhuman primates. Here we examine relationships between physiological levels of the neurotrophic incretin, plasma GLP-1 (pGLP-1), and body mass index (BMI) in adolescence to adult neurogenesis and associations with a diabesity diathesis and infant stress. Morphometry, fasting pGLP-1, insulin resistance, and lipid profiles were measured in early adolescence in 10 stressed and 4 unstressed male bonnet macaques. As adults, dentate gyrus neurogenesis was assessed by doublecortin staining. High pGLP-1, low body weight, and low central adiposity, yet peripheral insulin resistance and high plasma lipids, during adolescence were associated with relatively high adult neurogenesis rates. High pGLP-1 also predicted low body weight with, paradoxically, insulin resistance and high plasma lipids. No rearing effects for neurogenesis rates were observed. We replicated an inverse relationship between BMI and neurogenesis. Adolescent pGLP-1 directly predicted adult neurogenesis. Two divergent processes relevant to human diabesity emerge—high BMI, low pGLP-1, and low neurogenesis and low BMI, high pGLP-1, high neurogenesis, insulin resistance, and lipid elevations. Diabesity markers putatively reflect high nutrient levels necessary for neurogenesis at the expense of peripheral tissues.

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Yau, Suk-yu, Joana Gil-Mohapel, Brian R. Christie und Kwok-fai So. „Physical Exercise-Induced Adult Neurogenesis: A Good Strategy to Prevent Cognitive Decline in Neurodegenerative Diseases?“ BioMed Research International 2014 (2014): 1–20. http://dx.doi.org/10.1155/2014/403120.

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Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential preventative strategy/treatment to reduce cognitive decline. Here we review the functional role of adult hippocampal neurogenesis in learning and memory, and how this form of structural plasticity is altered in neurodegenerative diseases known to involve cognitive impairment. We further discuss how physical exercise may contribute to cognitive improvement in the ageing brain by preserving adult neurogenesis, and review the recent approaches for measuring changes in neurogenesis in the live human brain.

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Yuan, Ti-Fei, Jiang Li, Fei Ding und Oscar Arias-Carrion. „Evidence of adult neurogenesis in non-human primates and human“. Cell and Tissue Research 358, Nr. 1 (19.08.2014): 17–23. http://dx.doi.org/10.1007/s00441-014-1980-z.

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Gage, Fred H. „Adult neurogenesis in neurological diseases“. Science 374, Nr. 6571 (26.11.2021): 1049–50. http://dx.doi.org/10.1126/science.abm7468.

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Fan, Xiaoying, Yuanyuan Fu, Xin Zhou, Le Sun, Ming Yang, Mengdi Wang, Ruiguo Chen et al. „Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development“. Science Advances 6, Nr. 34 (August 2020): eaaz2978. http://dx.doi.org/10.1126/sciadv.aaz2978.

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Neurogenesis processes differ in different areas of the cortex in many species, including humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and pons during human embryonic and fetal development. We identified distinct subtypes of neural progenitor cells (NPCs) and their molecular signatures, including a group of previously unidentified transient NPCs. We specified the neurogenesis path and molecular regulations of the human deep-layer, upper-layer, and mature neurons. Neurons showed clear spatial and temporal distinctions, while glial cells of different origins showed development patterns similar to those of mice, and we captured the developmental trajectory of oligodendrocyte lineage cells until the human mid-fetal stage. Additionally, we verified region-specific characteristics of neurons in the cortex, including their distinct electrophysiological features. With systematic single-cell analysis, we decoded human neuronal development in temporal and spatial dimensions from GW7 to GW28, offering deeper insights into the molecular regulations underlying human neurogenesis and cortical development.

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Seonwoo, Hoon, Kyung-Je Jang, Dohyeon Lee, Sunho Park, Myungchul Lee, Sangbae Park, Ki-Taek Lim, Jangho Kim und Jong Chung. „Neurogenic Differentiation of Human Dental Pulp Stem Cells on Graphene-Polycaprolactone Hybrid Nanofibers“. Nanomaterials 8, Nr. 7 (21.07.2018): 554. http://dx.doi.org/10.3390/nano8070554.

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Stem cells derived from dental tissues—dental stem cells—are favored due to their easy acquisition. Among them, dental pulp stem cells (DPSCs) extracted from the dental pulp have many advantages, such as high proliferation and a highly purified population. Although their ability for neurogenic differentiation has been highlighted and neurogenic differentiation using electrospun nanofibers (NFs) has been performed, graphene-incorporated NFs have never been applied for DPSC neurogenic differentiation. Here, reduced graphene oxide (RGO)-polycaprolactone (PCL) hybrid electrospun NFs were developed and applied for enhanced neurogenesis of DPSCs. First, RGO-PCL NFs were fabricated by electrospinning with incorporation of RGO and alignments, and their chemical and morphological characteristics were evaluated. Furthermore, in vitro NF properties, such as influence on the cellular alignments and cell viability of DPSCs, were also analyzed. The influences of NFs on DPSCs neurogenesis were also analyzed. The results confirmed that an appropriate concentration of RGO promoted better DPSC neurogenesis. Furthermore, the use of random NFs facilitated contiguous junctions of differentiated cells, whereas the use of aligned NFs facilitated an aligned junction of differentiated cells along the direction of NF alignments. Our findings showed that RGO-PCL NFs can be a useful tool for DPSC neurogenesis, which will help regeneration in neurodegenerative and neurodefective diseases.

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Niklison-Chirou, Maria Victoria, Massimiliano Agostini, Ivano Amelio und Gerry Melino. „Regulation of Adult Neurogenesis in Mammalian Brain“. International Journal of Molecular Sciences 21, Nr. 14 (09.07.2020): 4869. http://dx.doi.org/10.3390/ijms21144869.

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Adult neurogenesis is a multistage process by which neurons are generated and integrated into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two specialized niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. Neurogenesis plays a fundamental role in postnatal brain, where it is required for neuronal plasticity. Moreover, perturbation of adult neurogenesis contributes to several human diseases, including cognitive impairment and neurodegenerative diseases. The interplay between extrinsic and intrinsic factors is fundamental in regulating neurogenesis. Over the past decades, several studies on intrinsic pathways, including transcription factors, have highlighted their fundamental role in regulating every stage of neurogenesis. However, it is likely that transcriptional regulation is part of a more sophisticated regulatory network, which includes epigenetic modifications, non-coding RNAs and metabolic pathways. Here, we review recent findings that advance our knowledge in epigenetic, transcriptional and metabolic regulation of adult neurogenesis in the SGZ of the hippocampus, with a special attention to the p53-family of transcription factors.

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Xu, Pei, Junling Gao, Chao Shan, Tiffany J. Dunn, Xuping Xie, Hongjie Xia, Jing Zou et al. „Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells“. PLOS Neglected Tropical Diseases 15, Nr. 3 (03.03.2021): e0009183. http://dx.doi.org/10.1371/journal.pntd.0009183.

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Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study, we used Asian-American lineage ZIKV strain PRVABC59 to infect primary human NS/PCs originally derived from fetal brains. We found that ZIKV overactivated key molecules in the innate immune pathways to impair neurogenesis in a cell stage-dependent manner. Inhibiting the overactivated innate immune responses ameliorated ZIKV-induced neurogenesis reduction. This study thus suggests that orchestrating the host innate immune responses in NS/PCs after ZIKV infection could be promising therapeutic approach to attenuate ZIKV-associated neuropathology.

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Kim, Curie, Ana Margarida Pinto, Claire Bordoli, Luke Patrick Buckner, Polly Charlotte Kaplan, Ines Maria del Arenal, Emma Jane Jeffcock, Wendy L. Hall und Sandrine Thuret. „Energy Restriction Enhances Adult Hippocampal Neurogenesis-Associated Memory after Four Weeks in an Adult Human Population with Central Obesity; a Randomized Controlled Trial“. Nutrients 12, Nr. 3 (28.02.2020): 638. http://dx.doi.org/10.3390/nu12030638.

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Adult neurogenesis, the generation of new neurons throughout life, occurs in the subventricular zone of the dentate gyrus in the human hippocampal formation. It has been shown in rodents that adult hippocampal neurogenesis is needed for pattern separation, the ability to differentially encode small changes derived from similar inputs, and recognition memory, as well as the ability to recognize previously encountered stimuli. Improved hippocampus-dependent cognition and cellular readouts of adult hippocampal neurogenesis have been reported in daily energy restricted and intermittent fasting adult mice. Evidence that nutrition can significantly affect brain structure and function is increasing substantially. This randomized intervention study investigated the effects of intermittent and continuous energy restriction on human hippocampal neurogenesis-related cognition, which has not been reported previously. Pattern separation and recognition memory were measured in 43 individuals with central obesity aged 35–75 years, before and after a four-week dietary intervention using the mnemonic similarity task. Both groups significantly improved pattern separation (P = 0.0005), but only the intermittent energy restriction group had a significant deterioration in recognition memory. There were no significant differences in cognitive improvement between the two diets. This is the first human study to investigate the association between energy restriction with neurogenesis-associated cognitive function. Energy restriction may enhance hippocampus-dependent memory and could benefit those in an ageing population with declining cognition. This study was registered on ClinicalTrials.gov (NCT02679989) on 11 February 2016.

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Scordel, Chloé, Alexandra Huttin, Marielle Cochet-Bernoin, Marion Szelechowski, Aurélie Poulet, Jennifer Richardson, Alexandra Benchoua, Daniel Gonzalez-Dunia, Marc Eloit und Muriel Coulpier. „Borna Disease Virus Phosphoprotein Impairs the Developmental Program Controlling Neurogenesis and Reduces Human GABAergic Neurogenesis“. PLOS Pathogens 11, Nr. 4 (29.04.2015): e1004859. http://dx.doi.org/10.1371/journal.ppat.1004859.

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Nano, Patricia R., und Aparna Bhaduri. „Mounting evidence suggests human adult neurogenesis is unlikely“. Neuron 110, Nr. 3 (Februar 2022): 353–55. http://dx.doi.org/10.1016/j.neuron.2022.01.004.

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Bueno, Carlos, und Salvador Martínez. „Neurogenesis similarities in different human adult stem cells“. Neural Regeneration Research 16, Nr. 1 (2021): 123. http://dx.doi.org/10.4103/1673-5374.286967.

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Danzer, Steve C. „Adult Neurogenesis in the Human Brain: Paradise Lost?“ Epilepsy Currents 18, Nr. 5 (September 2018): 329–31. http://dx.doi.org/10.5698/1535-7597.18.5.329.

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Kallur, Therése, Ramiro Gisler, Olle Lindvall und Zaal Kokaia. „Pax6 promotes neurogenesis in human neural stem cells“. Molecular and Cellular Neuroscience 38, Nr. 4 (August 2008): 616–28. http://dx.doi.org/10.1016/j.mcn.2008.05.010.

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Nogueira, A., und M. Teixeira. „Adult human neurogenesis: Less limited than previously thought“. Journal of the Neurological Sciences 381 (Oktober 2017): 347–48. http://dx.doi.org/10.1016/j.jns.2017.08.987.

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Paredes, Mercedes F., Shawn F. Sorrells, Arantxa Cebrian-Silla, Kadellyn Sandoval, Dashi Qi, Kevin W. Kelley, David James et al. „Does Adult Neurogenesis Persist in the Human Hippocampus?“ Cell Stem Cell 23, Nr. 6 (Dezember 2018): 780–81. http://dx.doi.org/10.1016/j.stem.2018.11.006.

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Yu, Diana Xuan, Francesco Paolo Di Giorgio, Jun Yao, Maria Carolina Marchetto, Kristen Brennand, Rebecca Wright, Arianna Mei et al. „Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells“. Stem Cell Reports 2, Nr. 3 (März 2014): 295–310. http://dx.doi.org/10.1016/j.stemcr.2014.01.009.

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Yu, Diana Xuan, Francesco Paolo Di Giorgio, Jun Yao, Maria Carolina Marchetto, Kristen Brennand, Rebecca Wright, Arianna Mei et al. „Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells“. Stem Cell Reports 3, Nr. 1 (Juli 2014): 217. http://dx.doi.org/10.1016/j.stemcr.2014.06.015.

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Murrell, W., G. Bushell, J. McGrath, P. Bates und A. Mackay-Sim. „Neurogenesis in vitro of adult human olfactory epithelium“. Schizophrenia Research 18, Nr. 2-3 (Februar 1996): 178–79. http://dx.doi.org/10.1016/0920-9964(96)85563-0.

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Ihunwo, AmadiO, LacksonH Tembo und Charles Dzamalala. „The dynamics of adult neurogenesis in human hippocampus“. Neural Regeneration Research 11, Nr. 12 (2016): 1869. http://dx.doi.org/10.4103/1673-5374.195278.

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Pérez-Brangulí, Francesc, Isabel Y. Buchsbaum, Tatyana Pozner, Martin Regensburger, Wenqiang Fan, Annika Schray, Tom Börstler et al. „Human SPG11 cerebral organoids reveal cortical neurogenesis impairment“. Human Molecular Genetics 28, Nr. 6 (22.11.2018): 961–71. http://dx.doi.org/10.1093/hmg/ddy397.

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Perminova, A. A., und V. A. Zinserling. „Neurogenesis in the adult human brain: morphological aspects“. Arkhiv patologii 80, Nr. 6 (2018): 55. http://dx.doi.org/10.17116/patol20188006155.

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Farahani, Ramin M., Saba Rezaei‐Lotfi, Mary Simonian, Munira Xaymardan und Neil Hunter. „Neural microvascular pericytes contribute to human adult neurogenesis“. Journal of Comparative Neurology 527, Nr. 4 (23.11.2018): 780–96. http://dx.doi.org/10.1002/cne.24565.

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