Dissertationen zum Thema „HPTM“
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Zhu, Yumei, und August Österle. „China's policy experimentation on long-term care insurance: Implications for access“. Wiley, 2019. http://dx.doi.org/10.1002/hpm.2879.
Der volle Inhalt der QuelleEriksson, Kjell. „HPM-vapen vs. kommersiell UAV“. Thesis, Försvarshögskolan, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-6273.
Der volle Inhalt der QuelleThis paper in military technology discusses whether high power microwaves can affect commercial UAVs. Two non-lethal HPM-weapons are analyzed. The data is collected from a scenario where there is a high risk for collateral damage. A Swedish Armed Forces study stated that the Air Defence Battalion lacks ability to affect small UAVs. The latest knowledge is obtained from the environment in the scenario, from research and from the industry. This knowledge has enabled a logical-mathematical parametric study on the scenario within a military perspective. The result of the study is the assessment that commercial UAVs are assessed to have low protection factor, facilitates decision to act in all environments and provides an electronic shield protection of a large surface at the same time. HPM-weapons can´t stand as a single system for protection against commercial UAVs and achieve guaranteed effect. However, HPM-weapons can complement other weapon systems and thus make the air defense stronger through systems of systems. HPM-weapons can reduce the capability deficiency against commercial UAVs.
Kreitlow, Matthias [Verfasser]. „Analyse von HPEM-Störungseffekten in Computer-Netzwerken / Matthias Kreitlow“. Düren : Shaker, 2019. http://d-nb.info/1196487332/34.
Der volle Inhalt der QuelleLanzrath, Marian [Verfasser], und Holger [Akademischer Betreuer] Hirsch. „HPEM-Verwundbarkeit des Smart Grid / Marian Lanzrath ; Betreuer: Holger Hirsch“. Duisburg, 2020. http://d-nb.info/1216038899/34.
Der volle Inhalt der QuelleNarahara, Sheryl K. „Occupational narratives of human performance technology (HPT)“. [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3329712.
Der volle Inhalt der QuelleTitle from PDF t.p. (viewed on Jul 19, 2010). Source: Dissertation Abstracts International, Volume: 69-10, Section: A, page: 3919. Adviser: Thomas Schwen. Includes supplementary digital materials.
Wessman, Thomas. „HPM som luftvärnsvapen mot kryssningsmissiler, en möjlighet?“ Thesis, Försvarshögskolan, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-1640.
Der volle Inhalt der QuelleAvdelning: ALB - Slutet Mag 3 C-uppsHylla: Upps. ChP T 03-05
SILVA, Tatiane Sousa. „Planejamento em saúde: interação entre gestores & usuários no HPSM Mário Pinotti“. Universidade Federal do Pará, 2011. http://repositorio.ufpa.br/jspui/handle/2011/2961.
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Planejar em Saúde não é um tema que se restrinja a uma única matriz disciplinar. Para tratá-lo é necessário buscar em diversas áreas do conhecimento numa perspectiva “transdisciplinar”. Nesta pesquisa tentarei compreender e assimilar novas formas de gestão na saúde para o HPSM Mario Pinotti (Belém-Pará) que não estejam, em sua essência, apenas representando uma capitulação diante de uma conjuntura difícil, ou em outras palavras sucumbindo diante das dificuldades atuais dos problemas advindos de uma sociedade moderna e com interesses tão múltiplos quantos seus atores. Partimos da manifestação da necessidade de proximidade entre as pessoas, no contexto da humanização da relação de pesquisa, requer uma postura de valorização da vida acima de qualquer processo estrutural e/ou técnicocientífico. Por esse motivo escolhemos Bourdieu como principal referência para uma pesquisa etnográfica em um ambiente micropolítico, sob a perspectiva do estabelecimento de uma relação compreensiva com os atores sociais atuantes. Esta opção metodológica é fundamental para a compreensão do objeto proposto, o que dificilmente pode ser feito a partir da escolha de procedimentos simplificados, tais como entrevistas padronizadas e pontuais. O que se abstraiu dos resultados desta pesquisa é que existe um anseio por parte dos gestores e profissionais em adequar a demanda do hospital à capacidade do hospital e não o contrário. Entretanto, é necessário que haja um equilíbrio entre ambos para que o planejamento atinja o objetivo proposto que é o de ordenar os recursos financeiros e humanos com máxima eficiência possível. Políticas e estratégias devem ser consideradas sob a égide de um planejamento participativo promovendo um diálogo entre os que dependem do sistema e trabalham no/para o sistema.
Make plans in the area of health is not an issue that is confined to a single disciplinary matrix. To treat it is necessary to look at different areas of knowledge from a "transdisciplinary" perspective. In this research I will try to understand and assimilate new forms of management in health for HPSM Mario Pinotti (Belém-Pará) that it's not in its essence, merely representing a capitulation to a difficult economic situation, or in other words, succumbing before the current difficulties of the problems arising from a modern society with interests such as multiple than their actors. We started from need for proximity between people, in the context of the humanization of the relationship of research requires an attitude of valuing life above any structural process and / or technical-scientific. For this reason we chose as the main reference to Bourdieu's ethnographic research in an environment micro political from the perspective of establishing a comprehensive relationship with social actors acting. This methodological approach is fundamental to understanding the proposed object, which can hardly be made from the choice of simplified procedures like punctual interviews. What is abstracted from the results of this research is that there is a yearning on the part of managers and professionals in adapting to the demands to the hospital capacity of the hospital and not vice versa. However, there must be a balance between both that the proposed design achieves the goal that is the sort of financial and human resources with maximum efficiency possible. Policies and strategies must be considered under the aegis of a participatory planning by promoting a dialogue between those who depend on the system and work in / for the system.
Rosales, Marc. „Study of SiGe HPT for radio over fiber applications“. Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1101/document.
Der volle Inhalt der QuelleThis research is focused on the study of silicon germanium based heterojunction bipolar phototransistors (SiGe HPTs) implemented in an 80GHz SiGe Bipolar process technology. It's application in a radio over fiber system for home area networks are investigated. RoF for Home area networks are envisioned to implemented with a minimal system cost. Operation at 850nm is identified as a critical parameter to achieve this goal. Low cost off the shelf optical components are readily available at this wavelength. The use of multi mode fibers (MMF) as opposed to higher cost single mode fiber (SMF) is sufficient for the bandwidth requirements in a home network environment. A monolithically integrated OE receiver chip would help in the overall reduction of the system cost by having the optical detector in the same chip with the electronic circuits. We have designed and implemented three terminal HPT (3T-HPT) structures. The two main groups of the HPT structures are: 1) HPTs with extended Base and Collector regions (xBC HPT) and 2) HPTs with extended Emitter, Base and Collector regions (xEBC HPT). Variations to improve optical coupling the though optimizations in the vertical stack and lateral size of the HPT. The measurements and characterization showed that all the structures are compatible with the process technology. The type of biasing used in the base of the HPT also influences the HPT performance. A constant current (CC) bias has higher extracted DC responsivity as compared to a constant voltage (CV) bias. The effects of the different passive base loads on the HPT responsivity are studied through simulation and measurement of fabricated circuits. The impedance presented on the base has a great influence on the HPT responsivity. The performance of an HPT as circuit component is studied using different HPT-HBT pair configurations. Tests and measurements verify that improvement in the classical transistor pair configurations are also present in the opto microwave response of the HPT-HBT pair. Finally, SiGe hpt is used in the development of a ROSA module for a radio over fiber systems for home area network
Arzaghi, Mandana. „Nouveau procédé d'hyperdéformation pour les tubes“. Thesis, Metz, 2010. http://www.theses.fr/2010METZ031S.
Der volle Inhalt der QuelleThe new severe plastic deformation (SPD) technique, designated as high pressure tube twisting (HPTT), is a continuous process for grain refinement in bulk metallic materials with tubular geometry. It consists of placing a mandrel into the tube before applying an axial compression directly on the tube confined on both sides to produce high hydrostatic pressure. The tube is then twisted by an external torque with the help of the friction force genrated by the hydrostatic pressure. The ultra-fine grained structures produced with HPTT were confirmed using transmission electron microscopy and their microstructure and mechanical properties were evaluated. The value of yield stress is increased monotonically with the deformation imposed by HPTT. Meanwhile, the inverse deformation path is proved to be less advantageous. Microstructural evolution is studied by EBSD technique and texture measurements were carried out using X-ray. Deformed samples have simple shear texture with relatively low intensities and the effect of the initial texture on the final texture persists up to shear strain of nearly 6. Grain-to-grain misorientation distribution functions are bimodal and the second pick become higher with increasing strain. Industrial application of this new SPD technique requires advanced modelling in terms of texture evolution and grain fragmentation process. For this purpose, the new grain refinement model proposed by Toth and al. was used. Grain refinement improves the texture simulation results significantly and gives information on the average grain size, grain size distribution and misorientation distribution function that can be directly compared to experimental results
Nilsson, Tony. „Investigation of Limiters For HPM and UWB Front-door Protection“. Thesis, Linköping University, Department of Electrical Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7836.
Der volle Inhalt der QuelleAn extensive investigation of front-door protection devices i.e. limiters has been made. The thesis work contains both HPM- and UWB-measurements done on various limiters, in order to characterize them. The measurements show that all limiters are not suitable as protection against HPM- and UWB-pulses. The limiters that were found to provide the best protection are limiters based on diode technologies. PIN- and Schottky-diodes generally shows very good performance and they fulfill many parameters that have been set by FOI. To obtain a full protection it is presumably necessary to use two or more limiters in combination, which complement each other.
En omfattande studie av framvägskopplingsskydd, dvs. limiters har gjorts. Examensarbetet innehåller resultat från både HPM- och UWB- mätningar som har gjorts på olika limitrar för att karaktärisera deras prestanda. Av resultaten från mätningarna kan man se att alla limitrar inte passar som skydd mot HPM- och UWB-pulser. De limitrar som tillhandahöll det bästa skyddet var baserade på olika diodtekniker. PIN- och Schottky-dioder visade sig överlag ha väldigt goda prestanda och de uppfyller många av de parametrar som bestämts av FOI. För att få ett heltäckande skydd är det förmodligen nödvändigt att man använder två eller flera limitrar i kombination, som kompletterar varandra.
Klint, Andreas. „En ny motmedelsprincip : Kan HPM användas som motmedelssystem för helikopterplattformar?“ Thesis, Försvarshögskolan, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-6758.
Der volle Inhalt der QuellePuleio, Francesco. „An Innovative Synchronization Technique for OpMiGua-based Mobile Backhauls : The IEEE 1588v2 HPTS Scheme“. Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for telematikk, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-11129.
Der volle Inhalt der QuelleNwulu, Equi Emmanuel. „Utility of the HPT Framework for Improving Distance Education in Nigeria“. Thesis, Walden University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10687499.
Der volle Inhalt der QuelleThe fusion of the Internet with instructional design, and curricula delivery methods eliminated transactional distance in online learning. However, distance education (DE) in Nigeria has not aligned its pedagogy to the new reality in technology. The purposes of this non-experimental, predictive, validity study were to determine faculty and administrators’ perceived barriers and concerns to online adoption and to validate the behavior engineering model (BEM) instrument. Ninety-six respondents from four public universities in Nigeria completed the questionnaires. Descriptive statistics and structural equation modeling (SEM) were used respectively, to assess barriers and concerns militating against faculty and administrators’ online adoption, as well as validate the survey instruments. For faculty and administrators, incentive, motive, knowledge and skills influenced DE adoption. Except for age, all demographic factors influenced faculty’s concerns. Gender was observed to influence administrators’ concern. “Level of online use” influenced neither faculty nor administrators’ concerns. Technographic characteristics influenced faculty, but not administrators.’ Though the BEM instrument was reliable in measuring faculty and administrator’s stages of concern, however, the 6-factor BEM, tested at the 95% significant level, did not give a good fit. The study contributes to positive social change by identifying gaps to effective DE implementation, and recommended the appropriate interventions to transform the DE experience for students and their universities. The study also proposed the framework to fast track Nigeria’s vision and mission for DE.
Poloprudský, Jakub. „Struktura a mechanické vlastnosti materiálů na bázi hořčíku zpracovaných metodou HPT“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400834.
Der volle Inhalt der QuelleNwulu, Equi. „Utility of the HPT Framework for Improving Distance Education in Nigeria“. ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4663.
Der volle Inhalt der QuelleCINQUE, LUIGIA. „Multi-integrated approach based on HPT-JT families for the identification of a set of biomarkers of Parathyroid Carcinoma“. Doctoral thesis, Università di Foggia, 2018. http://hdl.handle.net/11369/369205.
Der volle Inhalt der QuelleBackground. As part of the Hyperparathyroidism with Jaw Tumor syndrome (HPT-JT), parathyroid carcinoma (KP) is caused by mutations of the CDC73 tumor suppressor gene, encoding the parafibromin, a PAF1 co-transcription factor, involved in chromatin remodelling and cell cycle regulation. Mutations of MEN1 gene cause the namesake syndrome (MEN1), in whose parathyroid lesions are benign in 99% of cases: instead, in the last 40 ys, only 15 cases worldwide have been reported with the unusual association of KP in MEN1 syndrome. KP is a rare, aggressive life-threatening tumor for whose at the present current therapies resulted ineffective and the surgical removal of the lesion remains the only curative approach. However, to recognize in first diagnosis a malignant parathyroid lesion from an indolent hyperplasia or benign adenoma still represents a challenge, in absence of pathognomic signs, such as distant metastasis or local recurrences. So far, unsuccessful efforts have been made in search of clinical biomarkers that could address to the (best) surgery option (conservative/demolitive) in order to reduce the risk of recurrence and to extend the disease free survival. Purpose and methods. The present project aims to identify the genetic causes leading to the development of a parathyroid carcinoma (KP) and to detect a set of biomarkers for a possible unequivocal, early first diagnosis. We decided to apply high throughput strategies such Whole Exome Sequencing (WES) and Expression Profiling (EP) to familial cases (consisting of one or more affected subjects, non-affected carriers and healthy controls with the same genetic background) rather than to sporadic ones in order to, possibly, reduce the intrinsic variability caused by different genetic backgrounds. Our rare cohort consisted of 5 HPT-JT families with malignant parathyroid lesion and constitutional mutation of the CDC73 gene and a very rare family with MEN1 mutation associated with recurrent and familial KP. Results.WES analysis revealed that in 4 (out of 5) HPT-TJ families, surprisingly, only the affected subjects shared rare variants (MAF < 0.004) in genes encoding the integrins (ITGA3, ITGA2B, ITGA11, ITGAB6, ITGA9), cell surface receptors involved in cell adhesion to the extracellular matrix (ECM) and essential for proliferation, survival, adhesion and migration of cells. Moreover, other variants in genes encoding proteins involved in DNA repair such as FANCC and BRIP1; NOTCH4; RET; BRCA1; BLK; MUC12; KMT2C; Hedgehog target genes such as SMO, GLI3 were identified. Finally a variant in GLI2 gene was found inaffected subjects of MEN1- KP family. The EP analysis compared the affecteds vs controls between HPT-JT families and the unique MEN1-KP family. The analysis showed a differential expression of genes of immune system. The EP also evidenced that MEN1 and HPT-JT patients use different set of genes to control the calcium mobilization. Functional assay. Human embryonic kidney (HEK293) cell lines were transfected with eukaryotic expression vectors carrying WT or mutated CDC73 gene: 5 different mutations weretested in presence/absence of Bortezomib, a drug already used in clinic for the therapy of multiple mieloma. We proved that this proteasome inhibitor was able to partially rescue the expression of missense, inframe and even frameshift CDC73 gene deletions. Conclusions and perspectives. This preliminary project may help to find a biomarkers set for a prompt early diagnosis of KP, in order to suggest the best surgical approach and identify asymptomatic carriers in affected families for an efficient early intervention. We suppose that the onset/progression/aggressivity of KP may be due to the deregulation of proteins involved in cell-cell adhesion (such integrins); the derangement of immune system; the deregulation of the Hedgehog pathway and the lack of trigger factors, such as the proteins assigned to DNA integrity (FANCC, BRIP1, BRCA1). Finally we reported, for the first time, the possible use of a well known chemotherapy drug, the Bortezomib, for the therapy of KP CDC73 induced, taking into account that, so far, all the attempts to find an efficient drugs as alternative approach to the surgery, resulted ineffective.
Tränkner, Christine. „Mikrostruktur- und Texturentwicklung während massiver plastischer Verformung von NiAl bei tiefen Temperaturen“. Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230717.
Der volle Inhalt der QuelleNiAl is an intermetallic compound with a cubic B2 structure. Below the brittle-to-ductile transition temperature at about 300°C under ambient pressure the number of independent slip systems that have to be activated for a homogeneous plastic deformation is not sufficiently high according to the von Mises criterion. This is because the fracture stress is smaller than the critical yield stress for the activation of the secondary slip system. Despite this, severe plastic deformation is possible under a high pressure. It can be realized by deforming by equal channel angular pressing (ECAP) or high pressure torsion (HPT). Thereby a very high degree of deformation is reached. In this work, texture and microstructure evolution after deformation by HPT at different tem- peratures between room temperature and 500°C and at different hydrostatic pressures and degrees of deformation are analysed and compared to texture and microstructure after ECAP. After deformation by HPT, a texture typical for sheared body-centred metals is found; besides, for a deformation temperature of 100°C and higher an oblique cube component appears. It develops by dynamic recrystallization and grows with increasing deformation temperature. The shear texture also arises in the ECAP deformed samples, but no oblique cube texture is found. Both processes lead to grain refinement, which is influenced by deformation temperature, pressure, and degree of deformation. Tensile testing doesn’t show an enhanced ductility, but an improved strength is confirmed by microhardness measurements. If the degree of deformation is high enough, a shear texture can even be found after deforming single crystals
Al-Adsani, Ahmad Saad. „Hybrid permanent magnet machines for electric vehicles“. Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/hybrid-permanent-magnet-machines-for-electric-vehicles(457bd49f-4e9c-4f9b-8436-589ab5e2d02d).html.
Der volle Inhalt der QuelleDi, Domenico Daniel. „HPSM: uma API em linguagem c++ para programas com laços paralelos com suporte a multi-CPUs e Multi-GPUs“. Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/12171.
Der volle Inhalt der QuelleParallel architectures has been ubiquitous for some time now. However, the word ubiquitous can’t be applied to parallel programs, because there is a greater complexity to code them comparing to ordinary programs. This fact is aggravated when the programming also involves accelerators, like GPUs, which demand the use of tools with scpecific resources. Considering this setting, there are programming models that make easier the codification of parallel applications to explore accelerators, nevertheless, we don’t know APIs that allow implementing programs with parallel loops that can be processed simultaneously by multiple CPUs and multiple GPUs. This works presents a high-level C++ API called HPSM aiming to make easier and more efficient the codification of parallel programs intended to explore multi-CPU and multi-GPU architectures. Following this idea, the desire is to improve performance through the sum of resources. HPSM uses parallel loops and reductions implemented by three parallel back-ends, being Serial, OpenMP and StarPU. Our hypothesis estimates that scientific applications can explore heterogeneous processing in multi-CPU and multi-GPU to achieve a better performance than exploring just accelerators. Comparisons with other parallel programming interfaces demonstrated that HPSM can reduce a multi-CPU and multi-GPU code in more than 50%. The use of the new API can introduce impact to program performance, where experiments showed a variable overhead for each application, that can achieve a maximum value of 16,4%. The experimental results confirmed the hypothesis, because the N-Body, Hotspot e CFD applications achieved gains using just CPUs and just GPUs, as well as overcame the performance achieved by just accelerators (GPUs) through the combination of multi-CPU and multi-GPU.
Arquiteturas paralelas são consideradas ubíquas atualmente. No entanto, o mesmo termo não pode ser aplicado aos programas paralelos, pois existe uma complexidade maior para codificálos em relação aos programas convencionais. Este fato é agravado quando a programação envolve também aceleradores, como GPUs, que demandam o uso de ferramentas com recursos muito específicos. Neste cenário, apesar de existirem modelos de programação que facilitam a codificação de aplicações paralelas para explorar aceleradores, desconhece-se a existência de APIs que permitam a construção de programas com laços paralelos que possam ser processados simultaneamente em múltiplas CPUs e múltiplas GPUs. Este trabalho apresenta uma API C++ de alto nível, denominada HPSM, visando facilitar e tornar mais eficiente a codificação de programas paralelos voltados a explorar arquiteturas com multi-CPU e multi-GPU. Seguindo esta ideia, deseja-se ganhar desempenho através da soma dos recursos. A HPSM é baseada em laços e reduções paralelas implementadas por meio de três diferentes back-ends paralelos, sendo Serial, OpenMP e StarPU. A hipótese deste estudo é que aplicações científicas podem valer-se do processamento heterogêneo em multi-CPU e multi-GPU para alcançar um desempenho superior em relação ao uso de apenas aceleradores. Comparações com outras interfaces de programação paralela demonstraram que o uso da HPSM pode reduzir em mais de 50% o tamanho de um programa multi-CPU e multi-GPU. O uso da nova API pode trazer impacto no desempenho do programa, sendo que experimentos demonstraram que seu sobrecusto é variável de acordo com a aplicação, chegando até 16,4%. Os resultados experimentais confirmaram a hipótese, pois as aplicações N-Body, Hotspot e CFD, além de alcançarem ganhos ao utilizar somente CPUs e somente GPUs, também superaram o desempenho obtido por somente aceleradores (GPUs) através da combinação de multi-CPU e multi-GPU.
Neves, Juliana dos Santos 1982. „Efeito da administração intermitente de hPTH(1-34) nos estágios iniciais de reparo alveolar após exodontia de molares de ratos“. [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288496.
Der volle Inhalt der QuelleTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: A administração intermitente do hormônio paratireóideo (PTH) promove um aumento da massa óssea, sendo atualmente utilizado no tratamento de osteoporose. Entretanto, poucos estudos têm avaliado os efeitos do PTH sobre o metabolismo do osso alveolar, e mais especificamente, no processo de reparo desta estrutura, podendo este surtir um efeito favorável na cicatrização da ferida alveolar. Considerando-se que o padrão de cicatrização da ferida do alvéolo de molares de ratos é similar ao de humanos e a sua relevância clínica, este estudo teve como objetivo analisar o efeito da administração intermitente do PTH sobre o reparo alveolar após exodontia de molares de ratos. Ratas Wistar de 200g tiveram seus primeiros molares inferiores extraídos e receberam injeções subcutâneas de 40 ?g/kg de hPTH(1-34) (grupo PTH) ou solução veículo (grupo controle) em dias intemitentes após a exodontia. Os animais foram sacrificados aos 3, 5, 7 e 11 dias após a cirurgia. Análises histomorfométricas do volume de osso recém-formado, número de osteoblastos e osteoclastos TRAP-positivos foram realizadas em cortes histológicos seriados. O Ligante do receptor ativador do fator nuclear ?? (RANKL), Sialoproteína óssea (BSP) e Osteopontina (OPN) foram localizadas no alvéolo em cicatrização por imunohistoquímica. A expressão dos genes de Colágeno 1 (Col1?1), Fosfatase alcalina (Alp), Fator de crescimento insulínico (Igf-1), Osteocalcina (Ocn), Bsp, Opn, Osteoprotegerina (Opg) e Rankl, foi analisada por qRT-PCR. A presença de osso recém-formado foi notada em alvéolos a partir de 5 dias de reparo em ambos os grupos. O volume de osso recém-formado foi significativamente maior no grupo PTH nos períodos de 5, 7 e 11 dias (p<0.05), acompanhado de um número maior de osteoblastos aos 5 dias de reparo (p<0.05). No grupo controle houve um aumento gradual na expressão de todos os genes estudados, com exceção de OPN, nos períodos após a cirurgia. De um modo geral, a expressão de Col1?1, Alp, Igf-1 e Ocn foi maior no grupo PTH nos períodos iniciais, seguido por um decréscimo significativo aos 7 dias de reparo comparado ao grupo controle. A expressão de Bsp foi similar em ambos os grupos, enquanto a expressão de Opn foi menor vi no grupo PTH aos 7 e 11 dias de reparo, com estas proteínas apresentando a mesma distribuição nas trabéculas ósseas em formação no interior do alvéolo. O número de osteoclastos TRAP-positivos foi similar em ambos os grupos em todos os períodos avaliados, assim como o padrão de marcação para RANKL. Entretanto, a razão dos genes Rankl:Opg foi maior no grupo PTH aos 11 dias de reparo, sugerindo que o PTH pode favorecer a osteoclastogênese a partir deste período. Conclui-se que o tratamento intermitente com hPTH (1-34) teve um efeito anabólico sobre o processo de reparo do osso alveolar de forma pontual aos 5 dias, estimulando o aumento no número de osteoblastos e da expressão de genes relacionados a diferenciação e produção de matriz por estas células, causando consequentemente, um aumento no volume de osso recém-formado no interior do alvéolo
Abstract: The intermittent administration of parathyroid hormone (PTH) promotes an increase in bone mass, and it is currently used to treat osteoporosis. However, few studies have evaluated the effects of PTH on the metabolism of the alveolar bone, and more specifically in the repair process of this structure, which may have a positive effect on alveolar wound healing. Considering that the pattern of the alveolar wound healing post molar extraction in rats is similar to that of the humans and its clinical relevance, this study aimed to analyze the effect of intermittent PTH administration on alveolar wound healing after extraction of rat molars. Wistar rats (200g) had their first molars extracted and received subcutaneous injections of 40 ?g/kg of hPTH (1-34) (PTH group) or vehicle solution (control group) in alternated days after the extraction. The animals were sacrificed at 3, 5, 7 and 11 days after surgery. Histomorphometric analysis of the volume of newly formed bone, number of osteoblasts and TRAP-positive osteoclasts were performed on serial histological sections. Receptor activator of nuclear factor ?? ligand (RANKL), bone sialoprotein (BSP) and osteopontin (OPN) were localized at the healing socket by immunohistochemistry. Collagen 1 (Col1?1), alkaline phosphatase (Alp), insulin growth factor (Igf-1), osteocalcin (Ocn), Bsp, Opn, osteoprotegerin (Opg) and Rankl gene expression was assessed by qRT-PCR. Newly formed bone was observed in sockets from 5 days of repair in both groups. The volume of newly formed bone was significantly higher in PTH group at 5, 7 and 11 days of repair (p <0.05). In the control group there was a gradual increase in the expression of all genes studied, except for Opn, through the periods of healing. Overall, the expression of Col1?1, Alp, Igf-1 and Ocn in the PTH group was higher at the initial periods, followed by a significant down-regulation at 7 days of repair compared to the control group. Bsp expression was similar in both groups, while Opn expression was down-regulated by PTH at 7 and 11 days of repair. Both proteins showed the same distribution on the forming trabeculae in the socket. The number of TRAP-positive osteoclasts was similar in both groups in all periods of repair, as well as the labeling pattern for RANKL. However, viii Rankl:Opg ratio was higher in the PTH group at 11 days of repair, suggesting that PTH may promote osteoclastogenesis from this period. In conclusion, the intermittent treatment with hPTH-(1-34) had an anabolic effect on the alveolar wound healing specifically at 5 days of repair, stimulating an increase on the osteoblast number and on the expression of genes related to the differentiation and production of bone matrix by these cells, thereby resulting in increased volume of newly formed bone in the healing socket
Doutorado
Histologia e Embriologia
Doutor em Biologia Buco-Dental
Sabapathy, K. „Factors associated with the uptake of HIV testing and treatment in the first year of the HPTN 071 (PopART) intervention“. Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/4645535/.
Der volle Inhalt der QuelleCecilia, Johansson, und Fahira Kocevic. „Vägen till ändrade levnadsvanor : -erfarenheter från personer med övervikt och fetma“. Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-33694.
Der volle Inhalt der QuelleSome factors that contribute to overweight and obesity are lifestyle related and comprise a lack of physical activity and poor nutrition. Overweight and obese individuals may seek medical attention and acquire advice on how to lose their weight. The purpose of this study was to look into the experiences of the overweight and obese patients pertaining to lifestyle conversations with the district nurse. The study was conducted as an integrative literature overview, which enables a better understanding of a certain phenomenon within medical service. The results consist of sixteen scientific articles. The analysis reveals four categories: the significance of becoming motivated, the significance of one’s own attitude towards conversations about lifestyle, the significance of the district nurse’s communicative skills and the district nurse’s knowledge and competence. The communicative skills of the district nurse played a pivotal role in how the conversations about lifestyle were perceived by the patients. When the district nurse and the patient set individual goals together, the patient appeared more motivated to make a lifestyle change. On the other hand, the motivation of the patient decreased when the advice received was too generalized. Moreover, some patients believed that the district nurse was not adequately knowledgeable to deal with overweight and obesity. The categories correlate with Pender's health-promoting model as an explanation of patients' motivation in changing their lifestyles.
Courtin, Laurine. „Optimisation de la transformation à froid des tubes de gaine en acier austénitique 15-15TI AIM1“. Thesis, Poitiers, 2015. http://www.theses.fr/2015POIT2277/document.
Der volle Inhalt der QuelleIn order to face the next century energy demand growth, the worldwide development of the 4th generation of nuclear reactors is considered. The construction of a sodium-cooled fast reactor prototype (ASTRID) is currently envisaged at the CEA. The reference material selected for the fuel cladding of its first core is the 15-15Ti-AIM1 austenitic steel (Austenitic Improved Material).The goal of this PhD thesis work is to investigate the different ways of optimization for the coldworking steps undergone by the claddings during their manufacture in order to improve their swelling resistance. The main investigations are focused on the conditions of the cold-working steps and the thermal treatments applied throughout the shaping of the claddings, especially of the last solution annealing treatment. The effects of these parameters on the microstructure are investigated (structural refinement, precipitation and the additive elements dissolution and arrangement of the dislocations).This study is divided into three main steps:- an analysis of the fabrication routes applied in the past along with the study of the “coldwork” and the thermal treatments conditions;- an assessment of new shaping processes, such as the “cold-pilgering” and the hammering, in order to verify the conformity of the manufactured tubes with respect to the required specifications.- an attempt of optimization of the cold-work routes and the microstructure of the final material. The results of microstructure characterization and the mechanical behavior allow envisaging favorably the use of an alternative process such as the cold pilgering to manufacture claddings
Huang, Tsang-Min. „Phase Equilibria of Binary Liquid Crystal Mixtures Involving Induced Ordered Phases“. University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1284381816.
Der volle Inhalt der QuelleAndrews, Ronnee Nickole. „The Applicability of 8-Hydroxypyrene-1,3,6-trisulfonic Acid to Spectroelectrochemical Sensing“. University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1249999431.
Der volle Inhalt der QuelleSOUZA, AUREA de. „Comportamento do AnB/KOH/HPt-B na vulcanizacao do latex de borracha natural induzida com raios gama“. reponame:Repositório Institucional do IPEN, 1994. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10362.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Li, Ruo Ya. „Clonage d'une tyrosine-phosphatase membranaire (HPTP-béta) et étude de l'implication de la SH-PTP1 dans l'agrégation plaquettaire induite par la thrombine“. Toulouse 3, 1995. http://www.theses.fr/1995TOU30150.
Der volle Inhalt der QuelleMasi, Giulia. „Studio del ruolo di mutazioni missenso di CDC73 e microRNA in tumori CDC73-correlati familiari e sporadici“. Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422108.
Der volle Inhalt der QuelleMutazioni del gene oncosoppressore CDC73, codificante per parafibromina, sono associate alla sindrome da iperparatiroidismo-tumori mandibolari (HPT-JT): tale sindrome, a trasmissione autosomica dominante, è caratterizzata principalmente dall’insorgenza di tumori paratiroidei e, meno frequentemente, di fibromi ossificanti mandibolari e di vari tipi di anomalie uterine e renali, sia benigne che maligne. In letteratura non esistono dati riguardo allo stato mutazionale di CDC73 nei fibromi ossificanti mandibolari dei pazienti HPT-JT. Nel presente studio, è stata identificata una nuova mutazione somatica missenso di CDC73, Ile60Asn, nel tumore mandibolare di una paziente di una famiglia HPT-JT portatrice di una mutazione germinale frameshift di CDC73. Le mutazioni missenso di CDC73 sono molto rare, e spesso interessano residui nella porzione N-terminale di parafibromina, la cui funzione non è ancora nota. Secondo una predizione in silico, la sostituzione Ile60Asn è verosimilmente patogenetica, e altera un amminoacido altamente conservato. Per studiare in vitro il potenziale tumorigenico della mutazione, sono stati effettuati esperimenti nella linea cellulare HEK293A per analizzare possibili effetti su localizzazione subcellulare e livello di espressione della proteina mutata, proliferazione cellulare, apoptosi ed espressione di ciclina D1 e c-Myc. E’stato osservato che il mutante Ile60Asn era meno espresso della sua controparte wild-type, era privo di localizzazione nucleolare e mostrava ridotta capacità di inibizione dell’espressione di ciclina D1; inoltre, la frazione cellulare nelle fasi G2-M risultava aumentata nelle cellule trasfettate con parafibromina mutata. Non sono stati osservati effetti sull’espresione di c-Myc e sull’induzione di apoptosi. In conclusione, la mutazione Ile60Asn sembrava agire secondo un meccanismo di dominanza negativa, e non dare origina solamente ad una forma inattiva di parafibromina. La localizzazione nucleolare di parafibromina è verosimilmente cruciale per perrmettere alla proteina di esercitare le sue funzioni antiproliferative. Questi risultati indicano che i fibromi ossificanti mandibolari che insorgono in pazienti con HPT-JT non rappresentano effetti secondari dell’iperparatiroidismo, ma si presentano in seguito ad un secondo evento mutazionale a carico di CDC73. Le mutazioni di CDC73 non sono responsabili solamente dell’insorgenza di forme familiari di iperparatiroidismo primitivo: mutazioni inattivanti di questo gene, infatti, vengono identificate nel 77% circa dei tumori paratiroidei sporadici maligni. Un’elevata percentuale di carcinomi sporadici con anomalie a carico di CDC73 mostra una forte perdita di immunoreattività per parafibromina. Al contrario, negli adenomi paratiroidei sporadici, CDC73 non sembra avere un ruolo patogenetico di primo piano, dato che risulta mutato molto raramente (0-4%) nei tumori benigni. Tuttavia, secondo nostre precedenti esperienze, l’immunoreattività per parafibromina mostra elevata variabilità, senza differenze significative tra tumori paratiroidei sporadici benigni e maligni. Inoltre, sono stati osservati alcuni casi di adenoma paratiroideo sporadico privi di mutazioni di CDC73, ma con basso livello di espressione di parafibromina. E’quindi possibile ipotizzare l’esistenza di meccanismi, differenti dalla mutazione di CDC73, che possano causare una diminuzione dell’espressione di parafibromina: tra questi, una down-regolazione ad opera di microRNA (miRNA). Attualmente, in letteratura sono presenti solamente due studi sul profilo di espressione di miRNA nei tumori paratiroidei sporadici. Nel presente studio, è stato attuato un approccio di profiling con miRNA-microarrays in 8 adenomi e 3 carcinomi paratiroidei sporadici, per identificare miRNA differenzialmente espressi tra le due condizioni. L’analisi SAM non ha evidenziato miRNA significativamente differenti tra tumori benigni e maligni, mentre la Gene Set Enrichment Analysis su miRNA associati a determinate pathways cellulari ha identificato un arricchimento nei miRNA collegati alle pathways di PKC e PTEN negli adenomi, ed alla pathway di SHH nei carcinomi. E’stato scelto per ulteriori approfondimenti sperimentali miR-9, collegato ad entrambe le vie PKC e PTEN, che ha fra i suoi target predetti in silico CDC73. Il saggio dell’attività luciferasica e il western blot in cellule HEK293A hanno dimostrato che miR-9 era in grado di diminuire l’espressione di parafibromina. Inoltre, era presente un effetto indiretto sull’espressione di ciclina D1, più espressa in cellule trasfettate con miR-9. In sezioni incluse in paraffina dei tessuti tumorali impiegati per l’analisi con mirNA-microarrays, non sono state osservate correlazioni tra il livello di miR-9 e l’immunoreattività per parafibromina e ciclina D1. In conclusione, nei tumori paratiroidei sporadici non è stata evidenziata la presenza di miRNA differenzialmente espressi tra adenomi e carcinomi. MiR-9 ha CDC73 come target in vitro, ma in vivo non sembra essere responsabile delle differnze di immunoreattività per parafibromina e ciclina D1
Bejranonda, Somskaow. „An assessment of the soil erosion impacts on lakeside property values in Ohio: a hedonic pricing method (HPM) application“. Connect to resource, 1996. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1244216361.
Der volle Inhalt der QuelleCosta, Rosimeire Filgueira. „Contribui??o da poliacrilamida parcialmente hidrolisada em associa??o com a bentonita em fluidos de perfura??o aquosos“. Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20287.
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Neste trabalho, foi investigado o efeito da adi??o de poliacrilamida parcialmente hidrolisada (HPAM) e bentonita nas propriedades f?sico-qu?micas de fluidos de perfura??o aquosos. Duas formula??es foram avaliadas: a formula??o F1, que foi utilizada como refer?ncia, contendo carboximetilcelulose (CMC), ?xido de magn?sio (MgO), calcita (carbonato de c?lcio ? CaCO3 ), goma xantana, cloreto de s?dio (NaCl) e triazina (bactericida); e a formula??o F2, contendo HPAM em substitui??o a CMC e bentonita em substitui??o ? calcita. Os fluidos preparados foram caracterizados quanto ?s propriedades reol?gicas, a lubricidade e o volume de filtrado. A calcita foi caracterizada por granulometria e an?lise termogravim?trica (TGA). A formula??o F2 apresentou controle de filtra??o ? temperatura de 93 ?C 34 mL, enquanto a F1 apresentou filtra??o total. O coeficiente de lubricidade da formula??o F2 foi 0, 1623 e o da F1 0, 2542, acarretando uma redu??o de torque de 25% para F1 e de 52% para F2, comparado ? ?gua. Na temperatura de 49 ?C e taxa de cisalhamento 1022 s ?1 , as viscosidades aparentes foram 25, 5 e 48 cP para as formula??es F1 e F2, respectivamente, evidenciando maior resist?ncia t?rmica para F2. Com a comprova??o da maior estabilidade t?rmica de F2, um planejamento fatorial foi realizado, a fim de determinar as concentra??es de HPAM e de bentonita de melhor desempenho nos fluidos. O planejamento estat?stico gerou superf?cies de resposta indicando as melhores concentra??es de HPAM (4, 3 g/L) e de bentonita (28, 5 g/L) para se alcan?ar propriedades melhoradas dos fluidos (viscosidade aparente, viscosidade pl?stica, limite de escoamento e volume de filtrado) com 95% de confian?a, assim como as correla??es entre esses fatores (concentra??es de HPAM e bentonita). Os testes de envelhecimento t?rmico indicaram que as formula??es contendo HPAM e bentonita podem ser utilizadas ? temperatura m?xima de 150 ?C. A an?lise do reboco formado ap?s filtra??o dos fluidos por Difra??o de Raios X indicou intera??es espec?ficas entre a HPAM e a bentonita, justificando a maior estabilidade t?rmica do fluido F2 comparado ao F1, que suporta temperatura m?xima de 93 ?C.
In this study, we investigated the effect of addition of partially hydrolyzed polyacrylamide (HPAM) and bentonite in the physicochemical properties of acquous drilling fluids. Two formulations were evaluated: F1 formulation, which was used as reference, containing carboxymethylcellulose (CMC), magnesium oxide (MgO), calcite (calcium carbonate - CaCO3 ), xanthan gum, sodium chloride (NaCl) and triazine (bactericidal); and F2, containig HPAM steady of CMC and bentonite in substituition of calcite. The prepared fluids were characterized by rheological properties, lubricity and fluid loss. Calcite was characterized by granulometry and thermal gravimetric analysis (TGA). The formulation F2 presented filtration control at 93?C 34 mL while F1 had total filtration. The lubricity coefficient was 0.1623 for F2 and 0.2542 for F1, causing reduction in torque of 25% for F1 and 52 % for F2, compared to water. In the temperature of 49 ?C and shear rate of 1022 s ?1 , the apparent viscosities were 25, 5 and 48 cP for F1 and F2 formulation, respectively, showing greater thermal resistance to F2. With the confirmation of higher thermal stability of F2, factorial design was conducted in order to determine the HPAM and of bentonite concentrations that resulted in the better performance of the fluids. The statistical design response surfaces indicated the best concentrations of HPAM (4.3g/L) and bentonite (28.5 g/L) to achieve improved properties of the fluids (apparent viscosity, plastic viscosity, yield point and fluid loss) with 95% confidence, as well as the correlations between these factors (HPAM and bentonite concentrations). The thermal aging tests indicated that the formulations containing HPAM and bentonite may be used to the maximum temperature until 150 ?C. The analyze of the filter cake formed after filtration of fluids by X-ray diffraction showed specific interactions between the bentonite and HPAM, explaining the greater thermal stability of F2 compared to the fluid F1, that supports maximum temperature of 93 ?C.
Nanni, Jacopo. „High performance, low cost and low consumption Radio over fiber Systems for diversified communications applications“. Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC1162/document.
Der volle Inhalt der QuelleThis dissertation aims to analyze the possibility of improving in terms of cost and consumption the future Radio-over-Fiber (RoF) systems in different telecommunication scenarios, such as current and next generation of cellular networks and in other applications such as Radio Astronomy. The RoF system studied is hence composed of a Vertical Cavity Surface Emitting Laser (VCSEL) operating at 850 nm, standard single mode fiber (SSMF) and SiGe Heterojunction Phototransistor (HPT), adopting the technique called Intensity Modulation{Direct Detection which is nowadays the cheapest and simplest architecture for RoF. This dissertation describes in detail the multimode propagation within the SSMF (designed to operate only at 1310 nm and 1550 nm) which is present at 850 nm. Through a developed mathematical model, the two-modes propagation is described and the main phenomena involved are analyzed. In particular, the model focus on intermodal dispersion and modal noise which are considered the two main contributions of performance detrimental. The model developed is able to identify the main parameters which contribute to enhance the detrimental effects produced by intermodal dispersion and modal noise both in frequency and time domain. Starting from the model, possible techniques to improve the performances are then proposed. In particular, a pre-filtering technique is realized in order to avoid the excitation of the second order mode, allowing a quasi-single-modepropagation within the SSMF. The technique is theoretically and experimentally validated either for single radio frequency sinusoidal transmission either for bandpass signal transmission centered in radio frequency band. In particular it is demonstrated experimentally the possibility of increasing the modulationbandwidth of the RoF system, reducing at the same time the fluctuations of power and gain. Furthermore, the technique is validated in a real LTE transmission system, making the RoF technology proposed able to transmit 256-QAM LTE signal of 20 MHz bandwidth, confirming the possibility of using this technology to decrease the overall cost and consumption of the network. Further work hasbeen done on the mathematical model. In particular the two modes propagation is exploited reversely in order to characterize the chirp parameter of the VCSEL employed. Finally, the problem of coupling between fiber and opto-electronic devices is also discussed and investigated, in order to enhance theperformances while keeping low the cost. The possibility of utilizing a collective and passive ploymerbased structure for coupling the optical fiber with small area photodetectors and VCSEL is presented, showing important improvements on coupling efficiency and tolerance to misalignment
Meyer, Steven. „CONFIGURING TELEMETRY SYSTEMS FOR HIGH-POWER-MICROWAVE TESTING“. International Foundation for Telemetering, 1989. http://hdl.handle.net/10150/614467.
Der volle Inhalt der QuelleDuring high-power microwave (HPM) testing, where the item under test is subjected to power levels up to several thousand W/cm , the RF energy present will make typical 2 telemetry RF links useless. Therefore, other means must be used to retrieve the data during the tests. One method to accomplish data retrieval is to replace the RF data link with a fiber-optic link. This is done by replacing the transmitter with a fiber-optic transmitter on the sending end and the RF receiver with a fiber-optic receiver on the receiving end. Although this sounds simple, it is not always so. Solutions for PCM and FM-FM systems are relatively straightforward, whereas PAM systems present a unique set of problems. This paper addresses possible solutions for PCM and FM-FM and three possible solutions for PAM, one being by using a PAM-to-PCM converter.
Araujo, Viana Carlos. „Développement technologique et intégration système de VCSEL et HPT SiGe pour des applications radio-sur-fibre 60 GHz bas coût“. Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1003/document.
Der volle Inhalt der QuelleWireless communication technologies have become one of the most popular and indispensable part of people's lives in the recent years, offering mobility and services never before available from mobile communication until local network communication. This work is based on the frame of the French ORIGIN project and intended to explore the Home Area Network using the most recent Wi-Fi standard at 60 GHz with the goal to present a solution for the upcoming days where MultiGbit/s wireless communication will be required. The ORIGIN solution is characterized by the complementary action of two technologies: 60 GHz Wireless communication and Radio-over-Fiber (RoF) infrastructure. The project pretends to propose a real prototype based on RoF transducers and a Multipoint-to-Multipoint architecture to cover the entire house. This thesis covers from the single optoelectronic chip devices until the system implementation and the final demonstrator. The light source and the photodetector choice were very important since it dictated the RoF transducer architecture. Our choice was on 850 nm multimode devices (GaAs VCSEL and SiGe HPT) which allow relaxed constraints on the optical packaging and, therefore, low cost solutions. In terms of performances those devices are limited in a few tens of Gigahertz of bandwidth which was the reason for the intermediate frequency (IF) architecture. This thesis work addressed the electrical and optical interconnection of the optoelectronic chip devices. It explored the integration of hybrid amplification stages and passive networks within optoelectronic receivers and emitters. The optical packaging issues were addressed through a conventional coupling technique using a ball lens first. The die device performances were evaluated and compared with a packaged module in terms of frequency response, noise and nonlinearities. Since performances are usually measured as link performances we proposed a definition of the Opto-microwave figures of merit, such as Opto-microwave gain, noise, nonlinearities and EVM. They are presented and integrated into behavioral models, allowing both the individual performances extraction and system design. The integration of the RoF module in the system is the final part of this thesis. The performances were measured and simulated at each integration step. The final demonstrator based on the multipoint-to-multipoint architecture was implemented using an optoelectronic central node for the signal repartition and the Green Box for signal controlling. Real-time bidirectional transmission between two commercial WirelessHD devices at ~3 Gbit/s was validated. In a final section directions to improve VCSEL and SiGe HPT are explored. 25 GHz analogue VCSELs are explored with a focus on their dimensions, improved access and the potential of a suited matching approach. A novel collective and passive optical coupling technology is also proposed for both VCSEL and top illuminated detectors that couple smaller and faster devices
Hägg, Martin. „Theoretical analysis and simulation of microwave-generation from a coaxial vircator“. Thesis, Uppsala universitet, Fasta tillståndets elektronik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316595.
Der volle Inhalt der QuelleLindskog, Claes. „IC-påverkan av elektromagnetisk puls“. Thesis, Linköping University, Department of Electrical Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15092.
Der volle Inhalt der QuelleDetta examensarbete undersöker effekter av en elektromagnetisk puls på IC-kretsar.
För att kunna utvärdera inverkan har ett testobjekt, innehållande komponenter som skall testas, konstruerats. Detta testobjekt består av batteri, en enkel komponent och last. Ett pulsaggregat och en antenn användes för att generera de elektromagnetiska pulser som testobjektet utsattes för. Resultaten visar att inverkan på de testade komponenterna är möjlig. Inverkan visade sig vara beroende av bl.a. avståndet till antennen och den tid som testobjektet utsätts för störning. Störning har också utförts vid olika polariseringar.
Ett mål var att kunna jämföra en elektromagnetisk störning via en antenn med en trådbunden störning, där pulsen genererats från samma pulsaggregat. Försöken att utföra trådbunden störning av testobjektet misslyckades då pulsen inte var tillräckligt bra.
Detta examensarbete är en del av en artikel, High Power Ultra Wide Band and Vircator Source-Victim Experiment, som presenterades vid konferensen EMC Europe 2008.
This paper studies the effects of an electromagnetic pulse on IC-circuits. A DUT (device under test) has been constructed so that the effects of the pulse can be evaluated. The DUT consists of a battery, a load and the component, which is to be tested. A high voltage power supply and an antenna were used to generate the pulses that the DUT were exposed to. The results show that the effects were dependent on, among others, the distance between the antenna and the DUT and the time during which the DUT was exposed to the pulse. The DUT has also been exposed to different polarisations of the pulse.
One of the objectives of the study was to compare the difference between a pulse from an antenna and from a wire. This was to be done with the same high voltage power supply. Attempts to use a wire, for injecting the pulse, were unsuccessful since the damped pulse was not satisfying.
This paper is a part of a paper, High Power Ultra Wide Band and Vircator Source-Victim Experiment, that was presented at the conference EMC Europe 2008.
Kilburn-Watt, Elisabeth. „Altered Thyroid Hormone Regulation and Behavioural Change in a Sub-population of Rats following Injury“. Thesis, The University of Sydney, 2012. http://hdl.handle.net/2123/9098.
Der volle Inhalt der QuelleRabello, Guilherme Picanço. „Processamento remoto em solução para interação com ambientes arquitetônicos 3D através de tablets“. Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7840.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
The evolution of Computer Graphics, supported by the computational development, enables increasingly advanced visual creations and promotes benefits to various areas such as: Art, architecture, Product Design, Visual Design, Games, Movies, Engineering, GIS and Medicine. However, the processing power needed for applications that require a high degree of realism, restricts the use of these applications to a small portion of the entire range of the computing devices in use by the population. Recently, the evolution of mobile network technologies brought a possible solution to the inability of most mobile devices in dealing with interactive applications and a high degree of realism. The solution is based on the remote processing of applications on servers with high processing capacity, and delivery of the images produced for mobile devices made by its conversion into video and streaming broadcasts. This master dissertation explores a remote processing solution for interacting with architectural environments through tablets. Emphasis was placed in: keeping high degree of realism, difficult to achieve due to the processing requirements in real-time interactive applications; the adaptation and combination of tools available in the market; and in mitigating latency through different ways of user interaction. The evaluation of the results was carried out in training sessions, interaction and interviews with volunteers.
A evolução da Computação Gráfica apoiada no desenvolvimento computacional possibilita criações visuais cada vez mais avançadas promovendo benefícios a diversas áreas como: Artes, Arquitetura, Design de produto, Design visual, Jogos, Cinema, Engenharia, Geoprocessamento e Medicina. Porém, a capacidade de processamento exigida por aplicações que requerem elevado grau de realismo restringe o uso dessas aplicações a uma parcela pequena de toda a gama de dispositivos computacionais instalados e de uso da população. Recentemente, a evolução das tecnologias de rede móvel trouxe uma possível solução à incapacidade da maioria dos dispositivos móveis em lidar com aplicações interativas e de elevado grau de realismo. A solução baseia-se no processamento remoto das aplicações, em servidores com elevada capacidade de processamento, e na entrega das imagens produzidas para os dispositivos móveis feita através de sua conversão em vídeo e transmissão por streaming. Este trabalho explora uma solução de processamento remoto para interação com ambientes arquitetônicos através de tablets. Deu-se ênfase às questões de manutenção de elevado grau de realismo, dificultada pelas exigências de processamento em tempo real de aplicações interativas, à adaptação e combinação de ferramental disponível no mercado e à mitigação da latência através de recursos de interface com usuário. A avaliação dos resultados foi realizada em sessões de treinamento, interação e entrevistas com usuários voluntários.
Chiurazzi, Sara. „Valutazione dell'ormone TSH in Tursiops truncatus“. Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10029/.
Der volle Inhalt der QuelleGies, Cheryl E. „Evaluating Effectiveness of an Inpatient Nurse-directed Smoking Cessation Program in a Small Community Hospital“. University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1115124358.
Der volle Inhalt der QuelleBrandsch, Thomas [Verfasser], Ewa [Akademischer Betreuer] Stürmer, Franz-Josef [Akademischer Betreuer] Kramer und Patricia [Akademischer Betreuer] Virsik-köpp. „Einfluss der intermittierenden PTH-Applikation (hPTH 1-34) auf die Frakturheilung des metaphysären Knochens der orchiektomierten Ratte / Thomas Brandsch. Gutachter: Ewa Stürmer ; Franz-Josef Kramer ; Patricia Virsik-Köpp. Betreuer: Ewa Stürmer“. Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1044046309/34.
Der volle Inhalt der QuelleChen, Cai. „Textures et microstructures dans l'aluminium, le cuivre et le magnésium après hyperdéformation“. Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0061.
Der volle Inhalt der QuelleSevere plastic deformation (SPD) is an efficient technique to transform the microstructure of bulk metals into ultra fine grained structure with grain sizes less than 1 µm or even into nanostructure with nano-grains of less than 100 nm in diameter. The very small grain size attributes excellent mechanical properties to the material. In present thesis work, two recently developed SPD techniques, namely, High Pressure Tube Twisting (HPTT) and Cyclic Expansion and Extrusion (CEE) were performed on different metallic materials at room temperature. Details of fragmentation of microstructure and metallographic texture evolution were investigated by electron backscattered diffraction (EBSD), transmission electron microscopy (TEM), transmission kikuchi diffraction (TKD) and X-ray diffraction (XRD). Shear strain gradient across the thickness of the HPTT deformed Al tube sample was found by a local shear measurement method. This shear strain gradient induced the inhomogeneity of microstructure and texture in HPTT deformed pure Al, solid solution alloy Al-4%Mg and pure Mg. The microhardness and average grain size in different zones as a function of shear strain were measured. The limiting steady grain sizes in the steady state for these different materials produced by HPTT were 700 nm, 100 nm and 900 nm, respectively. The texture evolution of pure Mg in HPTT up to a shear strain of 16 was simulated in simple shear using the self-consistent (VPSC) polycrystal model and showed good agreements with the experimental results measured by XRD. Based on the measured disorientation distribution function in HPTT deformed Al, a new technique for the magnitude of local shear strain in SPD was proposed. This new technique was applied to a protrusion produced in twist extrusion (TE) and to an Al sample deformed in free-end torsion. Cu and pure Al samples were intensively deformed by the CEE SPD technique. The microstructure and texture evolutions were measured by EBSD, showing a gradient from the center-zone to the edge part of the rod sample. The texture evolution of CEE deformed Cu was simulated by the VPSC polycrystal model using a flow line function. The simulation results confirmed the experimental texture features observed in the CEE process. The tensile testing behavior of large strain torsion pre-processed Cu was examined. In spite of the shear strain gradient existing in the bar, a technique was proposed to obtain the tensile stress-strain curve of such gradient material
Diniz, Sandra Maria da Fonseca. „IMPLICAÇÕES DO DIABETES MELLITUS NA QUALIDADE DE VIDA DE INDIVÍDUOS, PARTICIPANTES DO PROGRAMA DE SAÚDE PARA O DIABÉTICO TIPO 2 DO HOSPITAL DO POLICIAL MILITAR (PSPD - HPM)“. Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/3110.
Der volle Inhalt der QuelleIt is about a study intended to evaluate the quality of life of diabetic militaries and his dependants (wives), to identify and associate the main risk factors that interfere on quality of life and make associations between quality of life and the main risk factors in diabetes mellitus 2 (DM2) patients through statistical significance and data mining. The study population was made out of 70 militaries and his wives, all patients with DM2 subscribed to the program entitled Attention, Prevention, Control and Treatment of DM2 of Military Police Hospital in Goiânia, GO, during the following period: from August to November 2008. Two closed questionnaires were applied, the first one referring to social-demographic variables, life style, clinical history, anthropometrical data, and the second one through a specific instrument of World Health Organization (WHO) to evaluate quality of life entitled WHOQOL bref. The most relevant variables and abrangência were: unbalanced diet with 78,6%, altered sugar rate with 91,5%, arterial hypertension with 54,2%, hypertension in the family with 71,4%. The complications referring to DM2 were foot injuries (25,7%), blindness (20,0%) and nephropathy (11,4%). The answers from survey individuals concerning the WHOQOL questionnaire bref detected that: 42 individuals (60,0%) considered their quality of life as good. However, 36 (51,4%) reported that they have negative feelings, sometimes. In relation to WHOQOL-bref domains, the ones of major prevalence were the social one followed by the environmental one. To execute the data mining method (Data Mininig, DM) it was utilized a tool known as Weka which allowed associations between the quality of life variables, risk factors and negative feelings. For the associations, attributes between themselves were strongly related, thus generating two associations. The first one - between quality of life and complications - and the second one - between quality of life, complications and negative feelings. Results demonstrated that the associations between quality of life, negative feelings and complications of DM have individual significance when related to the disease.
Trata-se de um estudo com objetivo de avaliar a qualidade de vida de militares diabéticos e seus dependentes (esposas), identificar e associar os principais fatores de risco que interferem na qualidade de vida, e realizar associações entre a qualidade de vida e os principais fatores de risco, em portadores de diabetes mellitus2 (DM2), através de técnicas estatísticas e da mineração de dados. A população de estudo foi constituída de 70 militares e suas esposas, todos portadores de DM2 inscritos no programa de atenção, prevenção, controle e tratamento de DM 2, do Hospital do Policial Militar em Goiânia, GO, no período de agosto a novembro de 2008. Foram aplicados dois questionários fechados, sendo o primeiro referente às variáveis sociodemográficas, estilo de vida, história clínica, dados antropométricos, e o segundo através de instrumento específico da Organização Mundial de Saúde (OMS), para avaliação da qualidade de vida, denominado WHOQUOL bref. As variáveis de maior relevância e abrangência foram: dieta não equilibrada com 78,6%, taxa de açúcar alterado com 91,5%, hipertensão arterial com 54,2%, hipertensão na família com 71,4%. As complicações referentes ao DM 2 encontradas foram a lesão em pé (25,7%) , a cegueira (20,0%) e a nefropatia (11,4%). As respostas dos sujeitos da pesquisa relativas ao questionário WHOQUOL bref detectaram que: 42 indivíduos (60,0%) consideram a sua qualidade de como boa. Entretanto, 36 (51,4%) relataram ter sentimentos negativos algumas vezes. Em relação aos domínios do WHOQOL-bref, os de maiores prevalência foram o social seguido do ambiental. Para a execução do método data mining (Mineração de Dados, MD) foi utilizada uma ferramenta conhecida como Weka que permitiu associações entre as variáveis qualidades de vida, fatores de risco e sentimentos negativos. Para as associações foram relacionados fortemente atributos entre si que geraram duas associações. A primeira entre qualidade de vida e complicações e a segunda entre qualidade de vida, complicações e sentimentos negativos. Os resultados mostram que as associações entre a qualidade de vida, os sentimentos negativos e as complicações do DM têm significado individual quando relacionados com a doença.
Girard, Maxime. „Recherche de vulnérabilités des étages de réception aux agressions électromagnétiques de forte puissance : cas d’un LNA AsGa“. Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0296/document.
Der volle Inhalt der QuelleIn this PhD thesis dissertation, a study of a GaAs low-noise amplifier (LNA) susceptibility tohigh power electromagnetic interference is presented.The term high power electromagnetic interference refers to a particular electromagneticenvironment in which E-field and H-field levels are high enough to cause physical damage tothe victim’s system electronic components.Such high level fields can be generated by dedicated systems, called electromagneticdirected energy weapons (DEW).The study presented in this document focuses not only on explaining failure mechanismstriggered by such interference, but also shows discussion on electromagnetic sourcesparameters trimming influence on component’s susceptibility
Can, Barboros. „Change Process Of Integrating Capability Maturity Model Integration (cmmi) Into A Technology Company: A Case Study“. Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612174/index.pdf.
Der volle Inhalt der Quellemotivation and adoption&rdquo
, &ldquo
adaptation&rdquo
, &ldquo
acceptance and implementation&rdquo
and finally &ldquo
use and improvement&rdquo
.
Bertheau, Lucie. „Caractérisation d'un phosphorelais multiple de type histidine-aspartate dans la transduction du signal de la contrainte osmotique chez le peuplier : mécanismes de régulation du fonctionnement d'un régulateur de réponse de type-B à l'échelle moléculaire“. Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2076/document.
Der volle Inhalt der QuelleMultistep His-to-Asp phosphorelay systems are signaling pathways devoted to signal perception and transduction for establishment of specific responses. These systems are composed of three successive partners: Histidine-aspartate Kinases (HKs), Histidine-containing Phosphotransfer proteins (HPts), and Response Regulators (RRs). One of the best characterized corresponding systems is the osmo-responsive pathway in yeast. Such systems are also suspected in Arabidopsis. This work aimed to characterize the involvement of an osmosensing pathway in Populus by identifying HPt and RR elements downstream of HK1 and to reveal the underlying mechanisms for the activity of a RR-B. HK1, membrane osmosensor, is expected to be responsible for signal detection and propagation by triggering the activation of three preferential HPt. Furthermore, an interacting partnership between those HPts and particular B-type RRs was observed. Two of them appear to be regulated by an osmotic stress, suggesting their possible involvement in this pathway. The B-type RR members, the final output elements of the pathway, act as transcription factors, as shown for at least for one of them in planta. Taken together, the dimerization of the RR receiver domain and its interaction with its DNA binding domain (GARP), are likely key checkpoints in the regulation of RR-B activity. Besides, the ability of one RR-B to bind its cognate specific DNA sequences (AGAT boxes) was confirmed in vitro and those were found in promoters of osmotic response genes. This work opens up prospects for the involvement of RR-B in the osmotic stress signaling pathway and suggests mechanisms tuning induction of specific responses
Luddeni, Giovanni. „Improvement of a simulation platform for Helicon Plasma Thrusters: analysis of the boundary conditions and modelling of the sheath“. Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24296/.
Der volle Inhalt der QuellePizarro, Torres Francisco. „Potentialités d’un plasma hors-équilibre localisé pour la réalisation d’antennes imprimées reconfigurables ou autolimitantes“. Thesis, Toulouse, ISAE, 2013. http://www.theses.fr/2013ESAE0048/document.
Der volle Inhalt der QuellePlasma is an ionized gas with physical characteristics that are of interest to the microwave domain. To simplify, we can characterize it as a dispersive medium whose dielectric permittivity depends on two parameters :the plasma pulsation wp and the electron-neutral collision frequency Vp. These two parameters depend mainly on the electron density of the gas and its pressure. If we can control the characteristics of the plasma, we can also control its dielectric permittivity, which allows us to consider the plasma for applications in the field of microwave reconfigurability.Among the structures that can generate a plasma discharge, we have focused on the use of recent topologies,known as plasma microdischarges. These microdischarges are of interest because of the possibility of easily integrating them into a RF device : small size, stability, temperature near room temperature and potential use at high pressures, including at atmospheric pressure.Given the difficulties in accurately modelling the effects of the plasma on a guided wave, an experimental approachwas preferred. Two measuring devices have been designed to characterize this interaction : a conventional microstrip transmission line and an inverted microstrip transmisison line, both including a microdischarge in their centers. With this experimental characterization, the S-parameters of the transmission line with the plasma are obtained and compared to those without plasma as a function of a wide range of parameters, such as gas pressure,frequency and current injected into the discharge.The results show two particularly interesting phenomena : a phase shift of the electromagnetic wave in presence of the plasma discharge and/or an important absorption of the incident power by the discharge. Two devices have been designed to exploit these results. The first is a frequency tunable microstrip patch antenna over a range of the order of one percent. In that case, the plasma changes the dielectric constant between the two conductors of the antenna. The second is a microstrip ring patch antenna that can protect the receiver from a high-power microwave (HPM) attack. When an incident electric field exceeds an adjustable preset threshold (tuned by an external DCvoltage source), a plasma discharge appears in the radiating element. The plasma then creates a mismatch and an absorption effect that limits, in a non-linear way, the received power at its input
GHIANI, LAVINIA. „THE HISTONE POST-TRANSLATIONAL MODIFICATION LANDSCAPE IN HPV+ AND HPV- HEAD AND NECK SQUAMOUS CELL CARCINOMA: CHARACTERIZING THE ONCOGENIC ROLE OF THE H3K36ME2 METHYLTRANSFERASE NSD2“. Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/820678.
Der volle Inhalt der QuelleCavanagh, Thomas. „THE KIOSK CULTURE: RECONCILING THE PERFORMANCE SUPPORT PARADOX IN THE POSTMODERN AGE OF MACHINES“. Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3793.
Der volle Inhalt der QuellePh.D.
Department of English
Arts and Humanities
Texts and Technology PhD;
Quedas, Elisangela Pereira de Souza. „Análise do proto-oncogene RET em pacientes com carcinoma medular de tireóide e megacólon congênito de uma família com mutação germinativa p.C620R“. Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-11012012-152825/.
Der volle Inhalt der QuelleThe multiple endocrine neoplasias (MENs) are inherited multi-tumoral conditions caused by germline mutations in specific genes. Specifically, the multiple endocrine neoplasia type 2 (NEM2) is a hereditary endocrine disorder transmitted dominantly and involving three main tumors, medullary thyroid carcinoma (CMT), primary hyperparathyroidism (HPT) and pheochromocytoma (PHEO). Despite the low prevalence of MEN2 in general population, the number of affected individuals per family can be significant as the penetrance of MEN2 is almost complete (~100%). In addition to CMT, PHEO and HPT, other conditions as congenital megacólon (Hirschsprung disease, HSCR or congenital intestinal aganglionosis) may occur in MEN2 (HSCR/MEN2). HSCR/MEN2 usually is due to RET mutations in codons 609, 618 and 620. HSCR has a wide phenotypic variation; is a complex multigenic disease; and has a low penetrance. Mutations in the RET gene are responsible for approximately 50% of the familial HSCR cases and ~10% of the sporadic HSCR cases, supporting that HSCR is a polygenic disease and this is confirmed by a few HSCR cases associated with mutations in the EDNRB and EDN3 genes. In the present study, we focused in the analysis of the RET gene in order to investigate whether the development of congenital megacólon in patients with RET mutation p.C620R is associated with the presence of, a) a second RET germline mutation, b) a SNP, or with a haplotype that co-segregate with the disease