Auswahl der wissenschaftlichen Literatur zum Thema „High resolution accurate mass (HRAM) mass spectrometry (MS)“
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Zeitschriftenartikel zum Thema "High resolution accurate mass (HRAM) mass spectrometry (MS)":
Hines, Jolaine M., Irina Bancos, Cristian Bancos, Raman D. Singh, Aditya V. Avula, William F. Young, Stefan K. Grebe und Ravinder J. Singh. „High-Resolution, Accurate-Mass (HRAM) Mass Spectrometry Urine Steroid Profiling in the Diagnosis of Adrenal Disorders“. Clinical Chemistry 63, Nr. 12 (01.12.2017): 1824–35. http://dx.doi.org/10.1373/clinchem.2017.271106.
Wiesinger, Thomas, Thomas Mechtler, Markus Schwarz, Xiaolei Xie, Regine Grosse, Paulina Nieves Cobos, David Kasper und Zoltan Lukacs. „Investigating the suitability of high-resolution mass spectrometry for newborn screening: identification of hemoglobinopathies and β-thalassemias in dried blood spots“. Clinical Chemistry and Laboratory Medicine (CCLM) 58, Nr. 5 (28.04.2020): 810–16. http://dx.doi.org/10.1515/cclm-2019-0832.
Lanzon, Borja, Marina Martin-Taboada, Victor Castro-Alves, Rocio Vila-Bedmar, Ignacio González de Pablos, Daniel Duberg, Pilar Gomez et al. „Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity“. Metabolites 11, Nr. 12 (03.12.2021): 836. http://dx.doi.org/10.3390/metabo11120836.
Ramanathan, Lakshmi, und Helen Shen. „LC–TOF–MS methods to quantify siRNAs and major metabolite in plasma, urine and tissues“. Bioanalysis 11, Nr. 21 (November 2019): 1983–92. http://dx.doi.org/10.4155/bio-2019-0134.
Yao, Jiaxu, Jinrui Zhu, Minjie Zhao, Li Zhou und Eric Marchioni. „Untargeted Lipidomics Method for the Discrimination of Five Crab Species by Ultra-High-Performance Liquid Chromatography High-Resolution Mass Spectrometry Combined with Chemometrics“. Molecules 28, Nr. 9 (22.04.2023): 3653. http://dx.doi.org/10.3390/molecules28093653.
Byrdwell, William C., und Hari Kiran Kotapati. „Multi-Dimensional Liquid Chromatography of Pulse Triacylglycerols with Triple Parallel Mass Spectrometry“. Separations 10, Nr. 12 (05.12.2023): 594. http://dx.doi.org/10.3390/separations10120594.
Moore, Eli K., Ellen C. Hopmans, W. Irene C. Rijpstra, Laura Villanueva, Svetlana N. Dedysh, Irina S. Kulichevskaya, Hans Wienk, Frans Schoutsen und Jaap S. Sinninghe Damsté. „Novel Mono-, Di-, and Trimethylornithine Membrane Lipids in Northern Wetland Planctomycetes“. Applied and Environmental Microbiology 79, Nr. 22 (30.08.2013): 6874–84. http://dx.doi.org/10.1128/aem.02169-13.
Abu-Reidah, Ibrahim M., Amber L. Critch, Charles F. Manful, Amanda Rajakaruna, Natalia P. Vidal, Thu H. Pham, Mumtaz Cheema und Raymond Thomas. „Effects of pH and Temperature on Water under Pressurized Conditions in the Extraction of Nutraceuticals from Chaga (Inonotus obliquus) Mushroom“. Antioxidants 10, Nr. 8 (23.08.2021): 1322. http://dx.doi.org/10.3390/antiox10081322.
Cawley, Adam, Daniel Pasin, Namuun Ganbat, Laura Ennis, Corrine Smart, Candace Greer, John Keledjian, Shanlin Fu und Alex Chen. „The potential for complementary targeted/non-targeted screening of novel psychoactive substances in equine urine using liquid chromatography-high resolution accurate mass spectrometry“. Analytical Methods 8, Nr. 8 (2016): 1789–97. http://dx.doi.org/10.1039/c6ay00156d.
Smith, Richard D. „Advanced Mass Spectrometric Methods for the Rapid and Quantitative Characterization of Proteomes“. Comparative and Functional Genomics 3, Nr. 2 (2002): 143–50. http://dx.doi.org/10.1002/cfg.159.
Dissertationen zum Thema "High resolution accurate mass (HRAM) mass spectrometry (MS)":
Maknun, Luluil. „Development of mass spectrometric analytical methods for the determination of iron complexes in plants and bacteria and for the determination of cobalt using bimetallic nanoparticles“. Electronic Thesis or Diss., Pau, 2023. http://www.theses.fr/2023PAUU3039.
The research focuses on an analytical method development using chromatography coupled to mass spectrometry for the analysis of low molecular weight iron complexes. In the second part, the study explores the utilization of bimetallic nanoparticles for Co2+ detection.In the first part, a method using liquid chromatography with two detector mass spectrometry, i.e., electrospray high-resolution accurate mass (HRAM) mass spectrometry (MS) and inductively coupled mass spectrometry (ICP-MS), was developed for the analysis of low molecular weight iron (Fe) complexes, called ‘siderophores'. The complexity of the samples, their low concentrations, and the lability of the iron complexe were challenges in the development of methods for their identification and quantification. For the sample clean-up, solid phase extraction (SPE) using acidic conditions was developed to purify the samples, followed by evaporation to dryness. The individual 56Fe-siderophore complexes were identified by fast size-exclusion chromatography (FastSEC) - Orbitrap MSn based on the exact molecular mass (+ 1 ppm) and MS2. Their capability of exchanging the natural 56Fe with the spiked 58Fe was demonstrated by SEC with ICP-MS and ESI-MS detection. The method was applied to the analysis of peat collected in the Eastern part of the French Pyrenean mountains. Nineteen siderophores belonging to four different classes were presumptively identified and quantified. The results were compared with ICP-MS detection of iron and matching of the sum of the moles of iron complexes determined by the isotopic- ESI-MS within each peak as eluted from the fastSEC column.In the second part, a method using inductively coupled plasma mass spectrometry in the single particle mode and the conventional mode coupled to a flow field flow fractionation was developed to select suitable conditions for the synthesis of Ag-Au bimetallic nanoparticles and to monitor the colorimetric changes due to aggregations. Ag-Au BNPs, synthesized by using citrate reduction of Ag and Au ions, were used as sensors for the detection of Co2+. To better understand the colorimetric sensing of Co2+ using the Ag-Au BNPs, various mixtures were studied, viz. (i) only Ag-Au BNPs; (ii) Ag-Au BNPs with thiosulfate; (iii) Ag-Au BNPs with thiosulfate and ethylenediamine; and (iv) Ag-Au BNPs with thiosulfate, Co2+ and ethylenediamine. SP-ICP-MS was used to determine the core size, size distribution, and number concentration, as well as the heterogeneity of the particles synthesized by using various citrate concentrations and metal ratios. Fl-FFF-ICP-MS was also used to observe the hydrodynamic size and the Ag: Au signal intensity ratio of the BNPs to support information obtained from the SP-ICP-MS. The combination of the proposed techniques has been applied to monitor the reaction during colorimetric sensing. Additional information from fractograms provided by Fl-FFF-ICP-MS was also useful for the understanding of the aggregation of BNPs arising from the [Co(II)(en)3]2+ complex surrounding the surface of the BNPs. Furthermore, when compared to colorimetric sensing, the limit of detection for Co2+ ion, using the BNPs and SP-ICP-MS, were 20-fold lower, decreasing from ppb to ppt levels
Huang, Fan. „APPLICATION OF HIGH-RESOLUTION ACCURATE MASS (HRAM) MASS SPECTROMETRY FOR ANALYSIS OF LIGNIN MODEL COMPOUNDS AND THE POST-PRETREATMENT PRODUCTS“. UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/74.
Broecker, Sebastian. „Aufbau und Anwendung einer Methode zur Identifizierung und Quantifizierung von Giften und deren Metaboliten in Blut und Haaren in der Systematischen Toxikologischen Analyse mittels Flüssigchromatographie-Quadrupol-Flugzeitmassenspektrometrie-Kopplung (LC-QTOF-MS)“. Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16461.
Due to the large variety and the steady increase of toxicologically relevant substances, systematic toxicological analysis (STA) is one of the most difficult tasks in analytical chemistry and, therefore, a steady topic of research and methodical improvement. For this reason, the suitability of liquid chromatography in combination with hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) for STA was investigated. For this purpose, a database of more than 7360 and a CID spectra library of more than 2720 toxicologically relevant substances and suitable methods for sample preparation were developed. The application was evaluated at spiked blood and hair samples. It was found that the analysis in Auto-MS/MS mode (alternating measurement cycles of MS and MS/MS spectra) allowed substance identification in blood using CID spectra between 0.5 and 2 ng/ml for basic substances. The detection limits of the validated method in hair ranged from 3 to 15 pg/mg for 24 drugs. The suitability of LC-QTOF-MS for STA was tested for hair samples from 30 drug-related death cases and from 60 death cases with known chronic medication as well as for 77 blood samples. For the search of metabolites, a metabolite tool was developed. In the practical application to data files from blood and hair samples, the tool proved to be very helpful for identification of unknown peaks and for confirmation of results obtained only from the database without CID spectra. A tool "Estimate Concentration" was created for automatic estimation of concentrations of identified substances. The application to real blood and hair samples and the comparison of the concentrations with results from HPLC-DAD and GC-MS showed good agreement. Overall, these investigations showed that LC-QTOF-MS is currently the most favorable method for STA. Because of the comprehensive registration of all substances in a sample, the data files can be checked for the presence of certain poisons even later without new measurements.
Larabi, Islam Amine. „Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry“. Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.
The aim of the present work was to develop two analytical approaches dedicated to the analysis of new psychoactive substances in different biological matrices (blood, urine and hair). The first approach is based on untargeted screening by both biochip array technology chemiluminescence assay and liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and the second corresponds to a targeted screening by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). These two approaches were then applied in observational studies to assess the consumption of NPS in high risk populations (overdose, drug abuse, drug facilitated crimes) in clinical and forensic settings. The last part of the work was devoted to the development of a new analytical tool for LC-HRMS data processing which made it possible to study the metabolism of 9 NPS In vitro on human liver microsomes (HLM) and In vivo in biological samples from drug users. This approach has enabled the creation of HRMS spectral library containing 228 metabolites, some of which have been proposed as relevant markers of NPS exposure.This work has resulted on 10 scientific publications and allowed to initiate many multidisciplinary collaborations
Buchteile zum Thema "High resolution accurate mass (HRAM) mass spectrometry (MS)":
Crutchfield, C. A., und W. Clarke. „High resolution accurate mass (HRAM) mass spectrometry“. In Mass Spectrometry for the Clinical Laboratory, 247–59. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-800871-3.00012-2.
McCullagh, James, und Neil Oldham. „Resolution, accurate mass, and sensitivity“. In Mass Spectrometry. Oxford University Press, 2019. http://dx.doi.org/10.1093/hesc/9780198789048.003.0004.
Gangwar, Shivanshu, Rohit Kumar, Mandeep Yadav, Himanshi Rathaur und Rizwan Ahmad. „ROLE OF LC-MS IN HIGH-THROUGHPUT SCREENING OF BIOMARKER“. In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 9, 108–20. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn9ch12.
Konferenzberichte zum Thema "High resolution accurate mass (HRAM) mass spectrometry (MS)":
Byrdwell, William, und Hari Kiran Kotapati. „Fast chromatography with dual parallel mass spectrometry for lipidomic analysis and regioisomer quantification of pulse lipids“. In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/kxye7490.
Ow, Hooisweng, Sehoon Chang, Gawain Thomas, Wei Wang, Afnan A. Mashat und Hussein Shateeb. „Automatable High Sensitivity Tracer Detection: Toward Tracer Data Enriched Production Management of Hydrocarbon Reservoirs“. In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206338-ms.
Santos, Luiz, Tom Buchanan, Kristina Srzentic, Kai Scheffler, Sara Carillo und Jonathan Bones. „Characterization of an IgG1 monoclonal antibody oxidation variants at intact, subunit and peptide levels by High Resolution Accurate Mass (HRAM) mass spectrometry“. In International Symposium on Immunobiological. Instituto de Tecnologia em Imunobiológicos, 2024. http://dx.doi.org/10.35259/isi.biomang.2024_63764.
Wei, Na, Enada Archibold, Grace Jairo und Heather Kuiper. „Development of a method for separation of geometric isomers of alpha-linolenic acid in human plasma by silver Ion HPLC and GC-NCI-MS“. In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fvyw5862.
Luo, Pan, Jonathan Harrist, Rabah Mesdour und Nathan Stmichel. „Moving Gas Geochemical Analysis from Lab to Field by Advanced Gas Sensor for Onsite Fluid Characterization and Time-Lapse Monitoring“. In SPE Middle East Oil & Gas Show and Conference. SPE, 2021. http://dx.doi.org/10.2118/204775-ms.