Thematische Bibliographien / Heterocycles and applications

Inhaltsverzeichnis

Zeitschriftenartikel
Dissertationen
Bücher
Buchteile
Konferenzberichte

Auswahl der wissenschaftlichen Literatur zum Thema „Heterocycles and applications“

Autor: Grafiati

Veröffentlicht am 18. Mai 2024

Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an

Wählen Sie eine Art der Quelle aus:

Machen Sie sich mit den Listen der aktuellen Artikel, Bücher, Dissertationen, Berichten und anderer wissenschaftlichen Quellen zum Thema "Heterocycles and applications" bekannt.

Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.

Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.

Zeitschriftenartikel zum Thema "Heterocycles and applications"

Andres, C. J., Derek J. Denhart, Milind S. Deshpande und Kevin W. Gillman. „Recent Advances in the Solid Phase Synthesis of Drug Heterocyclic Small Molecules“. Combinatorial Chemistry & High Throughput Screening 2, Nr. 4 (August 1999): 191–210. http://dx.doi.org/10.2174/1386207302666220204193145.

Der volle Inhalt der Quelle

Annotation:

Abstract: Because of their synthetic challenge, broad range of physical I chemical properties, and diverse biological activities, heterocycles continue to be of interest to both the academic and industrial chemist. This review covers recent advances in the solid phase synthesis of drug-like heterocyclic small molecules. Syntheses which form the heterocycle on the solid phase are emphasized; syntheses in which a preformed heterocycle is functionalized on the solid support have been omitted. The majority of references are from publication year 1999. This review should be of interest to anyone involved in, or contemplating the solid phase synthesis of small molecule drug-like heterocycles, especially for combinatorial chemistry applications.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Luna, Isadora Silva, Rayssa Marques Duarte da Cruz, Ryldene Marques Duarte da Cruz, Rodrigo Santos Aquino de Araújo und Francisco Jaime Bezerra Mendonça-Junior. „1,4-Dithiane-2,5-diol: A Versatile Synthon for the Synthesis of Sulfur-containing Heterocycles“. Current Organic Synthesis 15, Nr. 8 (17.12.2018): 1026–42. http://dx.doi.org/10.2174/1570179415666180821154551.

Der volle Inhalt der Quelle

Annotation:

Background: 1,4-Dithiane-2,5-diol (1,4-DTD) is the stable dimer of α-mercapto acetaldehyde. This commercially available ambidentade compound is characterized as having in its chemical structure one group that acts as an electrophile and another that acts as a nucleophile, this permits its use as versatile and efficient synthon in synthetic heterocycle procedures. Objective: The aim of this review is to present synthetic applications of 1,4-DTD in heterocyclic chemistry and their applicability to the synthesis of bioactive compounds. Conclusion: Gewald reactions to obtain C-4 and C-5 unsubstituted 2-amino-thiophene derivatives; sulfa- Michael/Henry and sulfa-Michael/aldol sequences to obtain polysubstituted tetrahydrothiophenes, and other heterocyclic reactions that allow synthesizing several functionalized sulfur-containing heterocycles such as thiazolidines, oxathiazinoles and thiazoles are presented and discussed. The use of such heterocyclics in subsequent reactions allows obtaining various bioactive compounds including the antiretroviral lamivudine which is one of the examples presented in this review.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Hoffman, Gavin R., und Allen M. Schoffstall. „Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines“. Molecules 27, Nr. 15 (22.07.2022): 4681. http://dx.doi.org/10.3390/molecules27154681.

Der volle Inhalt der Quelle

Annotation:

Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite or reacting hydrazine hydrate with dicarbonyl 1,2,3-triazoles. Several unique methods are known, particularly for the synthesis of 1,2,3-triazolo[1,5-a]pyrazines and their benzo-fused quinoxaline and quinoxalinone-containing analogs. Recent applications detail the use of these heterocycles in medicinal chemistry (c-Met inhibition or GABAA modulating activity) as fluorescent probes and as structural units of polymers.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Masdeu, Carme, Maria Fuertes, Endika Martin-Encinas, Asier Selas, Gloria Rubiales, Francisco Palacios und Concepcion Alonso. „Fused 1,5-Naphthyridines: Synthetic Tools and Applications“. Molecules 25, Nr. 15 (31.07.2020): 3508. http://dx.doi.org/10.3390/molecules25153508.

Der volle Inhalt der Quelle

Annotation:

Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in the fields of synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. In this review, a wide range of synthetic protocols for the construction of this scaffold are presented. For example, Friedländer, Skraup, Semmlere-Wolff, and hetero-Diels-Alder, among others, are well known classical synthetic protocols used for the construction of the main 1,5-naphthyridine scaffold. These syntheses are classified according to the nature of the cycle fused to the 1,5-naphthyridine ring: carbocycles, nitrogen heterocycles, oxygen heterocycles, and sulphur heterocycles. In addition, taking into account the aforementioned versatility of these heterocycles, their reactivity is presented as well as their use as a ligand for metal complexes formation. Finally, those fused 1,5-naphthyridines that present biological activity and optical applications, among others, are indicated.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Boelke, Andreas, Soleicha Sadat, Enno Lork und Boris J. Nachtsheim. „Pseudocyclic bis-N-heterocycle-stabilized iodanes – synthesis, characterization and applications“. Chemical Communications 57, Nr. 60 (2021): 7434–37. http://dx.doi.org/10.1039/d1cc03097c.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Kerru, Nagaraju, Lalitha Gummidi, Suresh Maddila, Kranthi Kumar Gangu und Sreekantha B. Jonnalagadda. „A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications“. Molecules 25, Nr. 8 (20.04.2020): 1909. http://dx.doi.org/10.3390/molecules25081909.

Der volle Inhalt der Quelle

Annotation:

The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Yadav, Shailendra, Sushma Singh und Chitrasen Gupta. „A CONCISE OVERVIEW ON HETEROCYCLIC COMPOUNDS EXHIBITING PESTICIDAL ACTIVITIES“. International Journal of Advanced Research 9, Nr. 08 (31.08.2021): 989–1004. http://dx.doi.org/10.21474/ijar01/13352.

Der volle Inhalt der Quelle

Annotation:

Heterocyclic compounds are numerous and diverse group of organic compounds. Heterocycles are abundantly found in nature and express various physiological properties. Heterocycles are intricately linked to all aspects of life. There are many heterocyclic compounds currently known, and the number is constantly rising owing to extensive synthetic development and their applications. Heterocyclic compounds are used significantly in a number of areas, including biochemistry and medicinal chemistry, and some others. They are predominantly synthesized in agrochemical and pharmaceutical industries due to their potential biological activities. This review article focuses on recently synthesized heterocyclic compounds and their different pesticidal activities such as antifungal, antibacterial, antiviral, nematocidal, insecticidal, acaricidal, and herbicidal.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Niedballa, Jonas, und Thomas J. J. Müller. „Heterocycles by Consecutive Multicomponent Syntheses via Catalytically Generated Alkynoyl Intermediates“. Catalysts 12, Nr. 1 (13.01.2022): 90. http://dx.doi.org/10.3390/catal12010090.

Der volle Inhalt der Quelle

Annotation:

Multicomponent processes are beneficial tools for the synthesis of heterocycles. As densely substituted bifunctional electrophiles, ynones are essential intermediates by applying cyclocondensations or cycloadditions in numerous heterocycle syntheses. The respective alkynoyl intermediates are generally accessible by palladium-, copper- and palladium/copper-catalyzed alkynylation. In turn, the mild reaction conditions allow for a fast and versatile entry to functional heterocycles in the sense of consecutive multicomponent processes. This review collates and presents recent advances in accessing thirteen heterocycle classes and their applications by virtue of catalytic alkynoyl generation in diversity-oriented multicomponent syntheses in a one-pot fashion.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Sparr, Christof, und Christian Fischer. „Configurationally Stable Atropisomeric Acridinium Fluorophores“. Synlett 29, Nr. 16 (03.08.2018): 2176–80. http://dx.doi.org/10.1055/s-0037-1610233.

Der volle Inhalt der Quelle

Annotation:

Arylated heterocyclic fluorophores are particularly useful scaffolds for numerous applications, such as bioimaging or synthetic photochemistry. While variation of the substitution pattern at the heterocycle and aryl groups allows dye modulation, the bond rotational barriers are also strongly affected. Unsymmetrically substituted ring systems of rotationally restricted arylated heterocycles therefore lead to configurationally stable atropisomeric fluorophores. Herein, we describe these characteristics by determining the properties and configurational stability of atropisomeric, tri-ortho-substituted naphthyl-acridinium fluorophores. A significant barrier to rotation of >120 kJ mol–1 was measured, which renders these dyes and related compounds distinct atropisomers with stereoisomer-specific properties over a broad temperature range.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Keszei, Soma J., Márk Váradi und Rita Skoda-Földes. „Urea-Functionalized Heterocycles: Structure, Hydrogen Bonding and Applications“. Molecules 28, Nr. 23 (24.11.2023): 7757. http://dx.doi.org/10.3390/molecules28237757.

Der volle Inhalt der Quelle

Annotation:

Ureido-heterocycles exhibiting different triple- and quadruple H-bonding patterns are useful building blocks in the construction of supramolecular polymers, self-healing materials, stimuli-responsive devices, catalysts and sensors. The heterocyclic group may provide hydrogen bond donor/acceptor sites to supplement those in the urea core, and they can also bind metals and can be modified by pH, redox reactions or irradiation. In the present review, the main structural features of these derivatives are discussed, including the effect of tautomerization and conformational isomerism on self-assembly and complex formation. Some examples of their use as building blocks in different molecular architectures and supramolecular polymers, with special emphasis on biomedical applications, are presented. The role of the heterocyclic functionality in catalytic and sensory applications is also outlined.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Mehr Quellen

Dissertationen zum Thema "Heterocycles and applications"

Richmond, Craig J. „Applications for imidazophenanthridine-based heterocycles“. Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1406/.

Der volle Inhalt der Quelle

Annotation:

The physical properties and reactivity of 2,3-dihydro-1H-imidazo[1,2-f]phenanthridinium cations (DIPs) and analogous heterocycles have been investigated. The adapted syntheses developed were applied to a range of aryl amines and more elaborate substrates, such as bifunctional aminoquinolinium cations and amino functionalised polyoxometalates (POMs). 1,2,3,12b-tetrahydroimidazo[1,2-f]phenanthridines (TIPs), an intermediate in the 3-step cascade synthesis of DIPs, have also been isolated. Derivatisation of the TIP structure at the imidazo-N position enables control of the reactivity of the intermediate with respect to electronic potential and pKa, allowing isolation of a selection of TIP structures. Correlations between these parameters and reaction outcome have been made and other influences such as steric and solvent effects have also been investigated. Investigation of the structure and properties of the TIP framework led to the discovery of a pH dependent cyclisation between the ring-closed TIP form and the ring-open aminoethylphenanthridinium (AEP) form. The complementary TIP and AEP forms can be further manipulated by oxidation or reduction to convert them to their “pH-inert” forms, DIP and aminoethyldihydrophenanthridine (AEDP). These four interchangeable states formed the basis of a redox “lockable” molecular switch that could be useful for molecular level information processing and data storage. The pH dependent cyclisation between the TIP and AEP forms was also investigated as a targeting mechanism for potential intercalating antitumour agents. The system looks to exploit the pH difference between cancerous tissues and normal tissue to combine high cytotoxicity with high selectivity, a desirable trait that is unfortunately absent in most chemotherapeutic agents. Preliminary in vitro assays have shown the TIP/AEP frameworks to have IC50 values in the pM range in human ovarian cancer cell lines, comparable to cisplatin and the closely related DIP intercalaters.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Davies, Deiniol Hedd. „Synthesis and applications of Guanidine Heterocycles“. Thesis, Bangor University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519556.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Mossaraf, Hossain. „Solvent free synthesis of some heterocycles and their applications“. Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/2621.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Rozgowska, Emma Jayne. „N-amino heterocycles : applications in flash vacuum pyrolysis“. Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5280.

Der volle Inhalt der Quelle

Annotation:

Routes to N-amino heterocycles were reviewed and findings applied to generate flash vacuum pyrolysis (FVP) precursors of two types - ketene generators and azol-1-yl radical generators. N-Amino heterocycles can be used as nitrogen radical generators, the N-N bond being homolytically cleaved at furnace temperatures of approximately 850 °C. A number of 2-substituted benzimidazoles were synthesised and subsequently Naminated. The 2-arylbenzimidazole precursors 1-amino-2-(2-methylphenyl)-1Hbenzimidazole and 1-amino-2-(2-ethylphenyl)-1H-benzimidazole were synthesised and subjected to FVP. The hydrogen transfer processes of the resulting azol-1-yl radicals were investigated. Pyrolysis of 1-amino-2-(2-methylphenyl)-1Hbenzimidazole resulted in three products; 2-(2-methylphenyl)-1H-benzimdazole, 11H-benzo[4,5]imidazo[1,2-a]isoindole and 1-(2-methylphenyl)-1Hbenzo[ d]imidazol-2-amine. Pyrolysis of 1-amino-2-(2-ethylphenyl)-1Hbenzimidazole resulted in five products, four of which have been successfully isolated and identified as 2-(2-ethylphenyl)-1H-benzimidazole, 5,6- dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline, 1-(2-ethylphenyl)-1Hbenzo[ d]imidazol-2-amine and 11-methyl-11H-benzo[4,5]imidazo[2,1-a]isoindole. The mechanism of formation of most products is initiated by hydrogen atom transfer to the azol-1-yl radical position. N-Aminopyrazole was reacted with 5-methoxymethylene-2,2-dimethyl-1,3-dioxane- 4,6-dione to form the corresponding 5-(N-aminopyrazolyl)methylene derivative, which, when subjected to FVP, eliminates acetone and carbon dioxide to form a methyleneketene. This subsequently undergoes a [1,3]-hydrogen shift giving an imidoylketene which can collapse onto the neighbouring nitrogen atom forming pyrazolo[1,2-a][1,2,3]triazin-5-ium-4-olate (a novel heterocyclic mesomeric betaine system) or cyclise onto the adjacent carbon atom to yield a pyrazolopyridazinone. On variation of the furnace temperature it was apparent the former forms at relatively moderate temperatures (~500 °C) whereas the latter begins to predominate as the furnace temperature increases (~700 °C). The relationship between these kinetic and thermodynamic products was modelled using DFT calculations. By using substituted pyrazole precursors, substituents could be incorporated into all three available positions around the pyrazole ring. Using substituted acrylic esters as alternative imidoylketene generators, substituents could also be incorporated into both available positions in the pyridazinone ring. All corresponding betaine and pyrazolopyridazinone products were isolated and characterised.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Tao, Beata 1973. „Applications of planar-chiral heterocycles in asymmetric catalysis“. Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/8047.

Der volle Inhalt der Quelle

Annotation:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2002.
Vita.
Includes bibliographical references.
The development of planar-chiral heterocycles for asymmetric catalysis and their applications to enantioselective processes were investigated. Reactions including the kinetic resolution of propargylic alcohols, the enantioselective ring opening of meso epoxides, and the asymmetric hydrosilylation of ketones were studied. ... During the past few years, our group has developed lb as one of the most effective and versatile nonenzymatic acylation catalysts for the kinetic resolution of arylalkylcarbinols. Surprisingly, however, when the optimized reaction conditions were applied to the kinetic resolution of secondary propargylic alcohols, only low to moderate selectivity factors were obtained. Detailed investigations revealed that triethylamine serves as a competitive general base catalyst in the acylation reaction of propargylic alcohols, thereby suppressing the intrinsic selectivity factor. When base is omitted, the selectivity factor for propargylic alcohol 2 (R1 = Ph, R2= Me) increases from 6 to 20. Using this new protocol, we can effect the kinetic resolution of a number of propargylic alcohols with selectivity factors of 10 or above. ... Catalysts in which oxygen is the nucleophilic site effect a number of useful transformations. In view of the utility of planar-chiral pyridine derivatives such as 1, it occurred to us that pyridine N-oxides 3 might also prove to be effective asymmetric catalysts. We synthesized complexes 3a-c and were gratified to discover that 3a efficiently catalyzes the ring opening of cis-stilbene oxide by SiC14, albeit in modest enantiomeric excess.
(cont.) By increasing the steric demand of the bottom ring, we found that the selectivity increases significantly. Thus, bulky derivative 3c affords 92% ee in the ring opening of cis-stilbene oxide at -85 C. A number of epoxides can be desymmetrized in very good yield and high stereoselectivity under these conditions (up to 98% ee). ... In addition, we have also synthesized a new family of planar-chiral N,P-ligands (4). The ligand design allows incorporation of different substituents on the phosphorus atom and on the C5R5 bottom ring, thereby providing a means for tuning catalyst enantioselectivity. We chose the asymmetric hydrosilylation of ketones to test the effectiveness of our ligand design. In general, sterically demanding silanes such as MesPhSiH2 and (o-tol)2SiH2 furnish better enantioselectivities than simple silanes like Ph2SiH2. Among the planar-chiral ligands tested, we found that ligand 4a gives the best yields and enantioselectivities for a wide array of substrates (arylalkyl ketones: up to 99% ee; dialkyl ketones: up to 96% ee). Deuterated benzaldehyde-l-d can also be reduced with excellent enantioselectivity (95% ee). Access to chiral silanes is also possible using the same ligand.
by Beata Tao.
Ph.D.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Shrestha, Tej Bahadur. „Heterocycles for life-sciences applications and information storage“. Diss., Kansas State University, 2010. http://hdl.handle.net/2097/13540.

Der volle Inhalt der Quelle

Annotation:

Doctor of Philosophy
Department of Chemistry
Stefan H. Bossmann
The photochromic spirodihydroindolizine/betaine (DHI/B) system has been reinvestigated applying picosecond, microsecond, stationary absorption measurements, and NMR-kinetics. The first surprise was that the electronic structure of the betaines is quite different than commonly assumed. The photochemical ring-opening of DHIs to betaines is a conrotatory 1,5 electrocyclic reaction, as picosecond absorption spectroscopy confirms. The (disrotatory) thermal ring-closing occurs from the cisoid betaine. The lifetime of the transoid betaine is 60 s at 300 K, whereas the lifetime of the cisoid isomer is of the order of 250 microseconds. According to these results, the electrocyclic back reaction of the betaines to the DHI is NOT rate determining, as previously thought, but the cisoid-transoid-isomerization of the betaine. Although the presence of a second nitrogen atom increases the photostability of the spirodihydroindolizine-pyridazine/betaine-system remarkably, the photochemical reaction mechanism appears to be exactly the same for spirodihydroindolizine-pyridazine/betaine-system. A nondestructive photoswitch or an information recording systems has been explored using styryl-quinolyldihydroindolizines. Both isomers DHI and betaine are fluorescent. When the blue betaine is stabilized in a thin polymethyl methacrylate (PMMA) matrix, it is stable for several hours even in room temperature and very stable at 77K. Although irradiation of visible light = 532 nm allows the photo-induced reaction of the Betaine back to the DHI, a nondestructive read-out can be performed at λ = 645 nm upon excitation with λ = 580 nm. Image recording (write) and read-out, as well as information storage (at 77K) have been demonstrated. Charged and maleimide-functionalized DHI/B systems have beed synthesized for use as photochemical gates of the mycobacterial channel porin MspA. Positively charged and maleimide functionalized DHI groups that were attached to the DHI/B-system permit the binding of the photoswitch to selective positions in the channel proteins due to the presence of a cysteine moiety. An inexpensive new method for the large scale synthesis of coelenterazine is developed. A modified Negishi coupling reaction is used to make pyrazine intermediates from aminopyrazine as an economical starting material. This method permits the use of up to 1g coelenterazine per kg body weight and day, which turns the renilla transfected stem cells into powerful light sources.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Goon, Simon. „Applications of the Vilsmeier reagent in synthesis“. Thesis, University of Sunderland, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245363.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Melling, Robert Craig. „Synthesis and applications of enantiopure N-heterocycles of C2-symmetry“. Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393104.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Fra, Fernández Laura. „New Applications of Iodine(III) Reactivity: Synthesis and Functionalization of Heterocycles“. Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/456301.

Der volle Inhalt der Quelle

Annotation:

S'han desenvolupat dues metodologies diferents per a la síntesi de indols emprant la reactivitat de iode hipervalente. En primer lloc, s'ha proposat una reacció de ciclació en la qual s'han obtingut un total de 21 exemples amb bons rendiments, a més d'estudiar el possible mecanisme d'aquesta reacció a través de diferents proves mecanístiques com ara la tècnica de marcatge de deuteri . D'altra banda, s'ha realitzat una metodologia alternativa amb substrats de partida diferents per obtenir un total de 18 exemples en bons rendiments a través tant d'una transformació estequiomètrica com catalítica. El mecanisme de la reacció s'ha estudiat en profunditat realitzant diferents estudis mecanístics, com per exemple, l'efecte dels substituents de diferent naturalesa electrònica en un dels anells aromàtics, a través de la correlació de Hammett. A més de l'aplicació de compostos de iode hipervalente per a la síntesi d'heterocicles, els seus derivats quirals s'han fet servir per al desenvolupament d'una reacció enantioselectiva per a la 4-hidroxilació de fenols.
Se han desarrollado dos metodologías diferentes para la síntesis de indoles empleando la reactividad de Yodo hipervalente. En primer lugar, se ha propuesto una reacción de ciclación en la que se han obtenido un total de 21 ejemplos con buenos rendimientos, además de estudiar el posible mecanismo de dicha reacción a través de diferentes pruebas mecanísticas como por ejemplo la técnica de marcaje de deuterio. Por otro lado, se ha realizado una metodología alternativa con sustratos de partida diferentes para obtener un total de 18 ejemplos en buenos rendimientos a través tanto de una transformación estequiométrica como catalítica. El mecanismo de la reacción se ha estudiado en profundidad realizando diferentes estudios mecanísticos, como por ejemplo, el efecto de los sustituyentes de diferente naturaleza electrónica en uno de los anillos aromáticos, a través de la correlación de Hammett. Además de la aplicación de compuestos de yodo hipervalente para la síntesis de heterociclos, sus derivados quirales se han usado para el desarrollo de una reacción enantioselectiva para la 4-hidroxilación de fenoles.
Two different methodologies have been developed for the synthesis of indoles using hypervalent iodine reactivity. First, a cyclization reaction has been proposed in which a total of 21 examples were obtained with good yields. In order to elucidate the reaction mechanism, different kinetic experimentes were performed such as the deuterium labellind technique . On the other hand, an alternative methodology has been performed with different starting materials obtaining a total of 18 examples in good yields through both a stoichiometric and catalytic transformation. The mechanism of the reaction has been studied by performing different mechanistic studies, such as the effect of the substituents of different electronic nature on one of the aromatic rings, through the Hammett correlation. In addition to the application of hypervalent iodine compounds for the synthesis of heterocycles, their chiral derivatives have been used for the development of an enantioselective reaction for the 4-hydroxylation of phenols.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Gentili, Denis <1982&gt. „Synthesis of five-membered heterocycles and of nanostructured systems for nanomedicine applications“. Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2461/1/Gentili_Denis_tesi.pdf.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Mehr Quellen

Bücher zum Thema "Heterocycles and applications"

R, Katritzky Alan, Hrsg. Novel applications of heterocycles in synthesis. Oxford: Pergamon, 1996.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

R, Katritzky Alan, Soldatenkov, A. T. (Anatoliĭ Timofeevich) und ebrary Inc, Hrsg. Heterocycles in life and society: An introduction to heterocyclic chemistry, biochemistry and applications. 2. Aufl. Chichester, West Sussex: Wiley, 2011.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

The chemistry of heterocycles: Structure, reactions, syntheses, and applications. 2. Aufl. [Weinheim]: Wiley-VCH, 2003.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Eicher, Theophil. The chemistry of heterocycles: Structure, reactions, syntheses, and applications. 2. Aufl. Weinheim: Wiley-VCH, 2004.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Eicher, Theophil. The chemistry of heterocycles: Structure, reactions, syntheses, and applications. Stuttgart: G. Thieme, 1995.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Synthetic applications of 1,3-dipolar cycloaddition chemistry toward heterocycles and natural products. Hoboken, NJ: Wiley, 2003.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Padwa, Albert, und William H. Pearson, Hrsg. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products. New York, USA: John Wiley & Sons, Inc., 2002. http://dx.doi.org/10.1002/0471221902.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

service), SpringerLink (Online, Hrsg. Halogenated Heterocycles: Synthesis, Application and Environment. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

1956-, Nylund Kristian, und Johansson Peder 1945-, Hrsg. Heterocyclic compounds: Synthesis, properties, and applications. Hauppauge, N.Y: Nova Science Publishers, 2009.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Patel, Ramesh. Triazines: Synthesis, applications, and toxicity. Hauppauge, N.Y: Nova Science Publishers, 2011.

Den vollen Inhalt der Quelle finden

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Mehr Quellen

Buchteile zum Thema "Heterocycles and applications"

Dwivedi, Sumant, und Tatsuo Kaneko. „Aromatic Bioplastics with Heterocycles“. In Green Polymer Chemistry: New Products, Processes, and Applications, 201–18. Washington, DC: American Chemical Society, 2018. http://dx.doi.org/10.1021/bk-2018-1310.ch014.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Mele, Giuseppe, Diego Lomonaco und Selma E. Mazzetto. „Cardanol-Based Heterocycles: Synthesis and Applications“. In Cashew Nut Shell Liquid, 39–56. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47455-7_3.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Nešpůrek, S., J. Sworakowski, J. Lipiński, S. Böhm und J. Kuthan. „Photocolouration of Hypervalent Heterocycles“. In Multiphoton and Light Driven Multielectron Processes in Organics: New Phenomena, Materials and Applications, 261–80. Dordrecht: Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4056-0_20.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Akritopoulou-Zanze, Irini, und Stevan W. Djuric. „Applications of MCR-Derived Heterocycles in Drug Discovery“. In Topics in Heterocyclic Chemistry, 231–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_46.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Akritopoulou-Zanze, Irini. „Applications of Isocyanides in the Synthesis of Heterocycles“. In Isocyanide Chemistry, 451–92. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527652532.ch13.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Chaudhuri, Haribandhu, Bhaskar Sarmah und Niranjan Karak. „Synthesis of Heterocycles Over Nanoporous Zeolites“. In Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications, 1–31. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-11155-7_26-1.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Dake, Satish A., Swapanil R. Sarda, Rajendra P. Marathe, Rajesh B. Nawale, Uday A. Deokate, Somshekhar S. Khadabadi und Rajendra P. Pawar. „Imidazolium Ionic Liquids: An Environment-Friendly Medium for Various Applications“. In Green Chemistry: Synthesis of Bioactive Heterocycles, 201–30. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0_7.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Rostamnia, Sadegh, und Esmail Doustkhah. „Synthesis and Synthetic Applications of Biologically Interesting Rhodanine and Rhodanine-Based Scaffolds“. In Green Chemistry: Synthesis of Bioactive Heterocycles, 253–75. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0_9.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Chung, Cheol K., und Matthew L. Crawley. „Transition Metal-Catalyzed Synthesis of Five- and Six-Membered Heterocycles“. In Applications of Transition Metal Catalysis in Drug Discovery and Development, 257–75. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118309872.ch6.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Ukaji, Yutaka, und Takahiro Soeta. „Development of New Methods for The Construction of Heterocycles Based on Cycloaddition Reaction of 1,3-Dipoles“. In Methods and Applications of Cycloaddition Reactions in Organic Syntheses, 263–82. Hoboken, New Jersey: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118778173.ch11.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Konferenzberichte zum Thema "Heterocycles and applications"

Prima, D. O., D. S. Baev, E. V. Vorontsova, T. S. Frolova, I. Yu Bagryanskaya, Yu G. Slizhov, T. G. Tolstikova, A. Yu Makarov und A. V. Zibarev. „New cancer cells apoptosis agents: Fluorinated aza-heterocycles“. In PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17). Author(s), 2017. http://dx.doi.org/10.1063/1.5001636.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Castro, M. Cidália R., A. Maurício C. Fonseca, M. Belsley und M. Manuela M. Raposo. „Highly efficient and thermally stable NLO organic materials based on pyrrole and thiophene heterocycles“. In International Conference on Applications of Optics and Photonics, herausgegeben von Manuel F. Costa. SPIE, 2011. http://dx.doi.org/10.1117/12.892205.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Castro, M. Cidália R., A. Maurício C. Fonseca, M. Belsley und M. Manuela M. Raposo. „Synthesis and evaluation of NLO properties of π-conjugated donor-acceptor systems bearing pyrrole and thiophene heterocycles“. In International Conference on Applications of Optics and Photonics, herausgegeben von Manuel F. Costa. SPIE, 2011. http://dx.doi.org/10.1117/12.892124.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Fadil MOUSA, Enaam, und Ibtissam Khalifa JASSIM. „SYNTHESIS ,CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY OF SOME HETEROCYCLIC COMPOUNDS“. In IV.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-18.

Der volle Inhalt der Quelle

Annotation:

Heterocycles are an important class of organic compounds because of their applications in medicines and industrial fields. Therefore our study included preparation of these compound such as oxazepine and quinazoline rings, which were prepared through two steps: The first step included the reaction of the Schiff bases derived from sulfamethaxazole (1-4) with each of phthalic anhydride and 3- nitrophthalic anhydride for the preparation of oxazepines (5-12) .While the second step included the preparation of quinazoline compounds (13-16) from the reaction of Schiff bases (1-4) with anthranilic acid using dry benzene as a medium and solvent for the reaction. All prepared compounds were characterized by using infrared,proton- nuclear magnetic resonance, mass techniques and melting points, and their purity was determined by thin layer chromatography technique also screened the biological activity of some of these prepared compounds by using two types of bacteria Gram-positive and negative . The results showed that these compounds have a good inhibition against these organisms

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Stevanović, Nevena Lj, Mia Stanković, Tina P. Andrejević, Darko P. Ašanin, Ivana M. Stanojević und Biljana Đ. Glišić. „DNA AND BSA INTERACTIONS OF COPPER(II) AND ZINC(II) COMPLEXES WITH ANTIFUNGAL AGENT FLUCONAZOLE“. In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.399s.

Der volle Inhalt der Quelle

Annotation:

Aromatic nitrogen-containing heterocycles (N-heterocycles) have attracted a considerable attention as scaffolds for compounds, which have an application in different pharmacological areas, ranging from vitamins to different antimicrobial and antitumor agents. In this respect, azoles are of special importance as potent and broad-spectrum agents used for the treatment of many invasive fungal infections. In the present study, the interaction of the clinically used antifungal drug fluconazole (fcz) and its copper(II) and zinc(II) complexes, {[CuCl2(fcz)2].5H2O}n (1) and {[ZnCl2(fcz)2]·2C2H5OH}n (2), with calf thymus DNA (ct- DNA) and bovine serum albumin (BSA) has been investigated. Fluorescence emission spectroscopy was applied for the binding study of complexes 1 and 2 and fcz with ct-DNA and BSA, while cyclic voltammetry was additionally used for investigation of their interactions with ct-DNA. The values of calculated binding constants (KA) of the investigated compounds towards ct-DNA and BSA follow the order fcz < 1 < 2 and 2 < fcz < 1, respectively.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Rosa, Fernanda A., Michael J. V. da Silva, Davana S. Gonçalves, Daniela H. Arita, Camila S. S. Tozatti und Gisele de F. G. Bandoch. „Synthetic Application of New Enaminodiketone: Regioespecific Synthesis of Aza-Heterocycles“. In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013101145054.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Ariunbold, Gombojav O., Bryan Semon, Surpiya Nagpal und Yuri Rostovtsev. „Cooperative Emissions from Hydrogen-Bonded Heterocyclic Organic Compounds“. In CLEO: Applications and Technology. Washington, D.C.: OSA, 2020. http://dx.doi.org/10.1364/cleo_at.2020.aw4k.4.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Shutalev, Anatoly. „New Synthetic Application of Ureidoalkylation in Heterocyclic Chemistry“. In The 1st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02013.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Twieg, Robert, S. Gu, L. Sukhomlinova, G. G. Malliaras, R. Fan und D. Culjikovic. „Heterocyclic liquid crystals designed for optical light emitting diode applications“. In Organic Thin Films. Washington, D.C.: OSA, 1999. http://dx.doi.org/10.1364/otf.1999.sud1.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Jaiswal, Shalini, Preeti Singh Bahadur, Ankita Mathur und Ruchira Srivastava. „Nuclear Magnetic Resonance Spectroscopy Application in charterization of Heterocyclic Compounds“. In 2021 International Conference on Technological Advancements and Innovations (ICTAI). IEEE, 2021. http://dx.doi.org/10.1109/ictai53825.2021.9673200.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Wir bieten Rabatte auf alle Premium-Pläne für Autoren, deren Werke in thematische Literatursammlungen aufgenommen wurden. Kontaktieren Sie uns, um einen einzigartigen Promo-Code zu erhalten!