Thematische Bibliographien / Hand1

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Auswahl der wissenschaftlichen Literatur zum Thema „Hand1“

Autor: Grafiati

Veröffentlicht am 30. Juni 2021

Zuletzt aktualisiert am 2. Februar 2022

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Zeitschriftenartikel zum Thema "Hand1"

Togi, Kiyonori, Takahiro Kawamoto, Ryoko Yamauchi, Yoshinori Yoshida, Toru Kita und Makoto Tanaka. „Role of Hand1/eHAND in the Dorso-Ventral Patterning and Interventricular Septum Formation in the Embryonic Heart“. Molecular and Cellular Biology 24, Nr. 11 (01.06.2004): 4627–35. http://dx.doi.org/10.1128/mcb.24.11.4627-4635.2004.

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ABSTRACT Molecular mechanisms for the dorso-ventral patterning and interventricular septum formation in the embryonic heart are unknown. To investigate a role of Hand1/eHAND in cardiac chamber formation, we generated Hand1/eHAND knock-in mice where Hand1/eHAND cDNA was placed under the control of the MLC2V promoter. In Hand1/eHAND knock-in mice, the outer curvature of the right and left ventricles expanded more markedly. Moreover, there was no interventricular groove or septum formation, although molecularly, Hand1/eHAND knock-in hearts had two ventricles. However, the morphology of the inner curvature of the ventricles, the atrioventricular canal, and the outflow tract was not affected by Hand1/eHAND expression. Furthermore, expression of Hand1/eHAND in the whole ventricles altered the expression patterns of Chisel, ANF, and Hand2/dHAND but did not affect Tbx5 expression. In contrast, the interventricular septum formed normally in transgenic embryos overexpressing Hand1/eHAND in the right ventricle but not in the boundary region. These results suggested that Hand1/eHAND is involved in expansion of the ventricular walls and that absence of Hand1/eHAND expression in the boundary region between the right and left ventricles may be critical in the proper formation of the interventricular groove and septum. Furthermore, Hand1/eHAND is not a master regulatory gene that specifies the left ventricle myocyte lineage but may control the dorso-ventral patterning in concert with additional genes.

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Hill, Alison A., und Paul R. Riley. „Differential Regulation of Hand1 Homodimer and Hand1-E12 Heterodimer Activity by the Cofactor FHL2“. Molecular and Cellular Biology 24, Nr. 22 (15.11.2004): 9835–47. http://dx.doi.org/10.1128/mcb.24.22.9835-9847.2004.

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ABSTRACT The basic helix-loop-helix (bHLH) factor Hand1 plays an essential role in cardiac morphogenesis, and yet its precise function remains unknown. Protein-protein interactions involving Hand1 provide a means of determining how Hand1-induced gene expression in the developing heart might be regulated. Hand1 is known to form either heterodimers with near-ubiquitous E-factors and other lineage-restricted class B bHLH proteins or homodimers with itself in vitro. To date, there have been no reported Hand1 protein interactions involving non-bHLH proteins. Heterodimer-versus-homodimer choice is mediated by the phosphorylation status of Hand1; however, little is known about the in vivo function of these dimers or, importantly, how they are regulated. In an effort to understand how Hand1 activity in the heart might be regulated postdimerization, we have investigated tertiary Hand1-protein interactions with non-bHLH factors. We describe a novel interaction of Hand1 with the LIM domain protein FHL2, a known transcriptional coactivator and corepressor expressed in the developing cardiovascular system. FHL2 interacts with Hand1 via the bHLH domain and is able to repress Hand1/E12 heterodimer-induced transcription but has no effect on Hand1/Hand1 homodimer activity. This effect of FHL2 is not mediated either at the level of dimerization or via an effect of Hand1/E12 DNA binding. In summary, our data describe a novel differential regulation of Hand1 heterodimers versus homodimers by association of the cofactor FHL2 and provide insight into the potential for a tertiary level of control of Hand1 activity in the developing heart.

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Firulli, Beth A., Rajani M. George, Jade Harkin, Kevin P. Toolan, Hongyu Gao, Yunlong Liu, Wenjun Zhang et al. „HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure“. Cardiovascular Research 116, Nr. 3 (09.07.2019): 605–18. http://dx.doi.org/10.1093/cvr/cvz182.

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Abstract Aims To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium. Methods and results Hand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic days (E) 9.5–13.5. Hand gene dosage plays an important role in ventricular morphology and the contribution of Hand1 to congenital heart defects requires further interrogation. Conditional ablation of Hand1 was carried out using either Nkx2.5 knockin Cre (Nkx2.5Cre) or α-myosin heavy chain Cre (αMhc-Cre) driver. Interrogation of transcriptome data via ingenuity pathway analysis reveals several gene regulatory pathways disrupted including translation and cardiac hypertrophy-related pathways. Embryo and adult hearts were subjected to histological, functional, and molecular analyses. Myocardial deletion of Hand1 results in morphological defects that include cardiac conduction system defects, survivable interventricular septal defects, and abnormal LV papillary muscles (PMs). Resulting Hand1 conditional mutants are born at Mendelian frequencies; but the morphological alterations acquired during cardiac development result in, the mice developing diastolic heart failure. Conclusion Collectively, these data reveal that HAND1 contributes to the morphogenic patterning and maturation of cardiomyocytes during embryogenesis and although survivable, indicates a role for Hand1 within the developing conduction system and PM development.

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Firulli, Beth A., Hannah Milliar, Kevin P. Toolan, Jade Harkin, Robyn K. Fuchs, Alex G. Robling und Anthony B. Firulli. „Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis“. Development 144, Nr. 13 (02.06.2017): 2480–89. http://dx.doi.org/10.1242/dev.149963.

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George, Rajani M., und Anthony B. Firulli. „Deletion of a Hand1 lncRNA-Containing Septum Transversum Enhancer Alters lncRNA Expression but Is Not Required for Hand1 Expression“. Journal of Cardiovascular Development and Disease 8, Nr. 5 (04.05.2021): 50. http://dx.doi.org/10.3390/jcdd8050050.

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We have previously identified a Hand1 transcriptional enhancer that drives expression within the septum transversum, the origin of the cells that contribute to the epicardium. This enhancer directly overlaps a common exon of a predicted family of long non-coding RNAs (lncRNA) that are specific to mice. To interrogate the necessity of this Hand1 enhancer, as well as the importance of these novel lncRNAs, we deleted the enhancer sequences, including the common exon shared by these lncRNAs, using genome editing. Resultant homozygous Hand1 enhancer mutants (Hand1ΔST/ΔST) present with no observable phenotype. Assessment of lncRNA expression reveals that Hand1ΔST/ΔST mutants effectively eliminate detectable lncRNA expression. Expression analysis within Hand1ΔST/ΔST mutant hearts indicates higher levels of Hand1 than in controls. The generation of Hand1 compound heterozygous mutants with the Hand1LacZ null allele (Hand1ΔST/LacZ) also did not reveal any observable phenotypes. Together these data indicate that deletion of this Hand1 enhancer and by consequence a family of murine-specific lncRNAs does not impact embryonic development in observable ways.

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Zheng, Mingjie, Shannon Erhardt, Di Ai und Jun Wang. „Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development“. International Journal of Molecular Sciences 22, Nr. 18 (11.09.2021): 9835. http://dx.doi.org/10.3390/ijms22189835.

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The bone morphogenetic protein (Bmp) signaling pathway and the basic helix–loop–helix (bHLH) transcription factor Hand1 are known key regulators of cardiac development. In this study, we investigated the Bmp signaling regulation of Hand1 during cardiac outflow tract (OFT) development. In Bmp2 and Bmp4loss-of-function embryos with varying levels of Bmp in the heart, Hand1 is sensitively decreased in response to the dose of Bmp expression. In contrast, Hand1 in the heart is dramatically increased in Bmp4 gain-of-function embryos. We further identified and characterized the Bmp/Smad regulatory elements in Hand1. Combined transfection assays and chromatin immunoprecipitation (ChIP) experiments indicated that Hand1 is directly activated and bound by Smads. In addition, we found that upon the treatment of Bmp2 and Bmp4, P19 cells induced Hand1 expression and favored cardiac differentiation. Together, our data indicated that the Bmp signaling pathway directly regulates Hand1 expression in a dose-dependent manner during heart development.

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KNÖFLER, Martin, Gudrun MEINHARDT, Sandra BAUER, Thomas LOREGGER, Richard VASICEK, Debra J. BLOOR, Susan J. KIMBER und Peter HUSSLEIN. „Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains“. Biochemical Journal 361, Nr. 3 (25.01.2002): 641–51. http://dx.doi.org/10.1042/bj3610641.

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The basic helix-loop-helix (bHLH) transcription factor, Hand1, plays an important role in the development of the murine extra-embryonic trophoblast cell lineage. In the present study, we have analysed the expression of Hand1 in human extra-embryonic cell types and determined its binding specificity and transcriptional activity upon interaction with different class A bHLH factors. Northern blotting and in situ hybridization showed that Hand1 mRNA is specifically expressed in amnion cells at different stages of gestation. Accordingly, we demonstrate that the protein is exclusively produced in the amniotic epithelium in vivo and in purified amnion cells in vitro using a novel polyclonal Hand1 antiserum. Reverse transcriptase-PCR and immunohistochemical staining of blastocysts revealed the production of Hand1 mRNA and polypeptide in the trophectodermal cell layer. In the presence of E12/E47, Hand1 stimulated the transcription of luciferase reporters harbouring degenerate E-boxes, suggesting that E-proteins are potential dimerization partners in trophoblastic tumour and amnion cells. In contrast, Hand1 diminished E12/E47-dependent transcription of reporters containing perfect E-boxes by inhibiting the interaction of Hand1/E-protein heterodimers with the palindromic cognate sequence. Furthermore, we show that Hand1 down-regulated GAL—E12-dependent reporter expression, indicating that the protein can also act directly as a transcriptional repressor. Mutational analyses of GAL-Hand1 suggested that two protein regions located within its N-terminal portion mainly confer the repressing activity. In conclusion, human Hand1 may play an important role in the differentiation of the amniotic membrane and the pre-implanting trophoblast. Furthermore, the data suggest that Hand1 can act as a repressor by two independent mechanisms; sequestration of class A bHLH factors from E-boxes and inhibition of their transcriptional activity.

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Asuthkar, Swapna, Maheedhara R. Guda, Sarah E. Martin, Reuben Antony, Karen Fernandez, Julian Lin, Andrew J. Tsung und Kiran K. Velpula. „Hand1 overexpression inhibits medulloblastoma metastasis“. Biochemical and Biophysical Research Communications 477, Nr. 2 (August 2016): 215–21. http://dx.doi.org/10.1016/j.bbrc.2016.06.045.

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Scott, Ian C., Lynn Anson-Cartwright, Paul Riley, Danny Reda und James C. Cross. „The HAND1 Basic Helix-Loop-Helix Transcription Factor Regulates Trophoblast Differentiation via Multiple Mechanisms“. Molecular and Cellular Biology 20, Nr. 2 (15.01.2000): 530–41. http://dx.doi.org/10.1128/mcb.20.2.530-541.2000.

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ABSTRACT The basic helix-loop-helix (bHLH) transcription factor genesHand1 and Mash2 are essential for placental development in mice. Hand1 promotes differentiation of trophoblast giant cells, whereas Mash2 is required for the maintenance of giant cell precursors, and its overexpression prevents giant cell differentiation. We found that Hand1 expression and Mash2 expression overlap in the ectoplacental cone and spongiotrophoblast, layers of the placenta that contain the giant cell precursors, indicating that the antagonistic activities ofHand1 and Mash2 must be coordinated. MASH2 and HAND1 both heterodimerize with E factors, bHLH proteins that are the DNA-binding partners for most class B bHLH factors and which are also expressed in the ectoplacental cone and spongiotrophoblast. In vitro, HAND1 could antagonize MASH2 function by competing for E-factor binding. However, the Hand1 mutant phenotype cannot be solely explained by ectopic activity of MASH2, as the Hand1mutant phenotype was not altered by further mutation ofMash2. Interestingly, expression of E-factor genes (ITF2 and ALF1) was down-regulated in the trophoblast lineage prior to giant cell differentiation. Therefore, suppression of MASH2 function, required to allow giant cell differentiation, may occur in vivo by loss of its E-factor partner due to loss of its expression and/or competition from HAND1. In giant cells, where E-factor expression was not detected, HAND1 presumably associates with a different bHLH partner. This may account for the distinct functions of HAND1 in giant cells and their precursors. We conclude that development of the trophoblast lineage is regulated by the interacting functions of HAND1, MASH2, and their cofactors.

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Sun, Xiandong, Jian Cao, Haiming Tong, Xizhe Zhang, Yi Sun, Zhimin Wei und Ronghai Man. „Involvement of HAND1 and CBS in maintenance of cardiac micro-architecture following obesity-induced heart failure“. Tropical Journal of Pharmaceutical Research 18, Nr. 4 (18.05.2021): 747–52. http://dx.doi.org/10.4314/tjpr.v18i4.10.

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Purpose: To study the role of heart and neural crest derivatives expressed 1 (HAND1) and cystathionine-beta-synthase (CBS) in the maintenance of cardiac architecture following high fat dietinduced obesity. Methods: Mouse models of initial and critical heart disease were established by continuous feeding of high fat diet for 7 and 12 months, respectively. The expression of HAND1 and CBS were assayed using immunohistochemistry and Western blotting. Results: Obesity led to mild and severe forms of heart disease which were confirmed through histological imaging. Initial obesity resulted in cardiac tissue remodeling along with initial degeneration, while critical obesity resulted in tissue hardening. The expression of HAND1 was upregulated 4.3 folds in the mild form of cardiac failure, relative to marginal expression pattern of HAND1 in control tissue. However, as the disease progressed, the expression of HAND1 was limited in serve form of cardiac failure. Moreover, the expression of cystathionine beta-synthase (CBS) was upregulated 3.7-fold in the initial form of heart failure, but was subsequently reduced in serve form of heart disease. Conclusion: These results reveal that in high fat diet-induced cardiac stress, the over-expressions of HAND1 and CBS at the initial stages induce extensive alterations in cardiac architecture.

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Dissertationen zum Thema "Hand1"

Martindill, David Michael John. „Developmental regulation of Hand1 via nucleolar sequestration“. Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444458/.

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The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis in the developing embryo. However, how the activity of Hand1 is regulated in either lineage remains largely unknown. Here we demonstrate that Hand1 is anchored in the nucleolus and negatively-regulated by the murine orthologue of the human I-mfa domain-containing protein (HIC). Nucleolar sequestration controls Hand1 activity during the differentiation of rat choriocarcinoma-1 (Rcho-1) trophoblast cells. Hand1 is sequestered in the nucleoli of Rcho-1 stem cells but is released into the nucleoplasm at the onset of their differentiation into trophoblast giant cells. Site-specific phosphorylation of Hand1 was previously shown to modulate the affinity of Hand1 for its nucleoplasm E-factor binding partners. We demonstrate that Hand1 phosphorylation is required for its nucleolar release, as a pre-requisite for dimerisation and biological function. Moreover, the polo-like kinase Plk4 (Sak) is responsible for this phosphorylation event. Plk4 localises to the nucleolus of Rcho-1 stem cells at phase G2 and interacts with Hand1 in vitro and in vivo to promote mitotic cell cycle exit and entry into the endocycle. We also demonstrate that the B568 subunit of the PP2A phosphatase, shown previously to target Hand1 for dephosphorylation, is exported from the nucleus during Rcho-1 differentiation. In this thesis we present findings that describe a novel mode of Hand1 regulation that is a crucial step in trophoblast stem cell differentiation and placentation and support previous studies that implicate the nucleolus as a molecular 'sink'. We suggest that nucleolar sequestration is an important mode of protein regulation and this may impact on a broad range of transcription factors.

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Risebro, Catherine Ann. „The role of Hand1 in cardiac morphogenesis“. Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445824/.

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Handl encodes a bHLH transcription factor, which is essential for both placentation and cardiac morphogenesis during murine development. Extraembryonic defects in homozygous mutant embryos have precluded detailed analysis of Handl function in the heart. To circumvent the Handl-null early lethality and gain insight into the precise function of Handl during vertebrate heart development the bimodal tetracycline (Tet- Off) system has been employed to generate temporally controlled loss of function and gain of function models for Handl. The Tet-Off system comprises a tet-off transactivator and tet response element (responder) whereby transactivation of the responder and gene of interest can be switched off following addition of doxycycline. The transactivator has been targeted to the endogenous Handl locus {Tet-Off Handl) ensuring it is expressed in a spatial and temporal pattern consistent with the endogenous gene and generated transgenic lines for the responder (Tre2-Handl). Compound heterozygotes in either Handl-null or wild type backgrounds enable us to temporally switch off or over-express Handl respectively. Transactivator and responder constructs for gene targeting and transgenics respectively have been tested extensively in vitro, and sent to a commercial company to generate the mouse strains. Germline transmission was achieved for both Tet-Off-Handl and two transgenic Tre2-Handl strains. The Tre2-Handl responder lines failed to express Handl at a level suitable to rescue the mutant phenotype when crossed with the Tet-Off- Handl driver on a Handl-null background thus preventing further manipulation via dox administration to pregnant mothers to turn off Handl at different embryonic stages. However, a third line suitably expressed Handl under the tet-system and is currently being crossed with the driver for determining rescue as a first step towards validating the loss of function model. The transactivator and responder lines have also been crossed to generate mice that over-express Handl. At E9.5, embryos that over-express Handl have an extended outflow tract, convoluted looping of the linear heart tube and a small, thick-walled ventricle, which lacks a defined lumen. Marker analysis reveals inappropriate cardiomyocyte differentiation and an over-proliferation in the affected areas with a lack of ballooning in the presumptive left ventricle. In vitro differentiation studies have also been performed in ES cell lines that stably and precociously over-express Handl to complement the in vivo model.

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Courtney, Jennifer A. „The Role of Abnormal Placentation in Congenital Heart Defects“. University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623165569297281.

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Togi, Kiyonori. „A role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart“. Kyoto University, 2004. http://hdl.handle.net/2433/145274.

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Chandrasekhar, Chaya. „Påla-period Buddha images their hands, hand gestures, and hand-held attributes /“. Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092830047.

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Thesis (Ph. D.)--Ohio State University, 2004.
Document formatted into pages; contains xvi,375 p.; also contains graphics. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2009 Aug. 18.

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Chandrasekhar, Chaya. „Pāla-Period Buddha Images: their hands, hand gestures, and hand-held attributes“. The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1092830047.

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Kontoudis, Georgios Pantelis. „Adaptive, Anthropomorphic Robot Hands for Grasping and In-Hand Manipulation“. Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/87404.

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This thesis presents the design, modeling, and development of adaptive robot hands that are capable of performing dexterous, in-hand manipulation. The robot hand comprises of anthropomorphic robotic fingers, which employ an adaptive actuation mechanism. The mechanism achieves both flexion/extension and adduction/abduction, on the finger's metacarpophalangeal joint, by using two actuators. Moment arm pulleys are employed to drive the tendon laterally, such that an amplification on the abduction motion occurs, while also maintaining the flexion motion. Particular emphasis has been given to the modeling and the analysis of the actuation mechanism. Also, a model for spatial motion is provided that relates the actuation modes with the finger motion and the tendon force with the finger characteristics. For the hand design, the use of differential mechanisms simplifies the actuation scheme, as we utilize only two actuators for four fingers, achieving affordable dexterity. A design optimization framework assess the results of hand anthropometry studies to derive key parameters for the bio-inspired actuation design. The model assumptions are evaluated with the finite element method. The proposed finger has been fabricated with the Hybrid Deposition Manufacturing technique and the actuation mechanism's efficiency has been validated with experiments that include the computation of the finger workspace, the assessment of the force exertion capabilities, the demonstration of the feasible motions, and the grasping and manipulation capabilities. Also, the hand design is fabricated with off-the-shelf materials and rapid prototyping techniques while its efficiency has been validated using an extensive set of experimental paradigms that involved the execution of grasping and in-hand manipulation tasks with everyday objects.
Master of Science
This thesis presents the design, modeling, and development of adaptive robot hands that are capable of performing selective interdigitation, robust grasping, and dexterous, in-hand manipulation. The robotic fingers employ an adaptive actuation mechanism. The design is minimal and the hand is capable of performing selective interdigitation, robust grasping, and dexterous, in-hand manipulation. Particular emphasis has been given to the modeling and the analysis of the actuation mechanism. For the hand design, the use of differential mechanisms simplifies the actuation scheme, as we utilize only two actuators for four fingers, achieving affordable dexterity. A design optimization framework assess the results of hand anthropometry studies to derive key parameters for the actuation design. The robotic fingers and the anthropomorphic hand were fabricated using off-the-self materials and additive manufacturing techniques. Several experiments were performed to validate the efficacy of the robot hand.

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Nagai, Kiyoshi. „Studies on Grasping and Manipulation by Robotic Multifingered Hands and Arm-Hand Systems“. Kyoto University, 1995. http://hdl.handle.net/2433/160756.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである
Kyoto University (京都大学)
0048
新制・論文博士
博士(工学)
乙第8782号
論工博第2944号
新制||工||980(附属図書館)
UT51-95-B247
(主査)教授吉川恒夫, 教授井上紘一, 教授島進
学位規則第4条第2項該当

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Yates, Juliet Rose. „Hands-on modernism : representations of the hand in Dorothy Richardson's Pilgrimage and modernist literature 1914-1939“. Thesis, Keele University, 2012. http://eprints.keele.ac.uk/1186/.

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The fragmentation endemic to modernism poses the difficult question of how we read the modernist body. In this thesis, I propose a new critical approach in response to this question – theoretical partialism – whereby looking at the particular and reading the representation of the hand as a signifier offers further insight into wider concerns such as, female subjectivity, performativity, sexuality and societal positioning. Because the hand can be both male and female, it allows for an interpretation of the body which does not rely on biological determinism, masculine discourse or essentialist feminism but, instead, provides the site for a new understanding of the body and constructions of gendered identities. Theoretical partialism finds its origins in psychoanalysis, sexology and feminist discourse and suggests that the hand can be used as a starting point for a wider theoretical discussion of totality. The paradox of the hand’s power of unification and differentiation is explored and the fetishistic approach reveals that there is not necessarily one totality but the potential of understanding different interpretations of the total. Therefore, theoretical partialism is used not as a method of regaining conventional ideas of totality but rather as a means for gaining a reconstituted notion of the whole and of selfhood from the fragments of modernity. My thesis develops this approach through readings of six texts: predominantly Dorothy Richardson’s Pilgrimage; Arthur Munby’s material is also investigated in order to establish the hand’s significance in the Victorian imagination; and as a method of illustrating the extent to which the hand features as a signifier in modernism, I explore the fragmented form and gendered identities in James Joyce’s Ulysses, T. S. Eliot’s The Waste Land, Katherine Mansfield’s “The Little Governess” and Jean Rhys’s Voyage in the Dark.

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Sheikholeslami, Sara. „Data-driven design of expressive robot hands and hand gestures : applications for collaborative human-robot interaction“. Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61300.

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Fast and reliable communication between human workers and robotic assistants (RAs) is essential for successful collaboration between these agents. This is especially true for typically noisy manufacturing environments that render verbal communication less effective. This thesis investigates the efficacy of nonverbal communication capabilities of robotic manipulators that have poseable, three-fingered end-effectors (hands). This work explores the extent to which different poses of a typical robotic gripper can effectively communicate instructional messages during human-robot collaboration. Within the context of a collaborative car door assembly task, a series of three studies were conducted. Study 1 empirically explored the type of hand configurations that humans use to nonverbally instruct another per- son (N=17). Based on the findings from Study 1, Study 2 examined how well human gestures with frequently used hand configurations were under- stood by recipients of the message (N=140). Finally, Study 3 implemented the most human-recognized human hand configurations on a 7-degree-of- freedom (DOF) robotic manipulator to investigate the efficacy of having human-inspired hand poses on a robotic hand compared to an unposed hand (N=100). Contributions of this work include the presentation of a set of hand configurations humans commonly use to instruct another person in a collaborative assembly scenario, as well as Recognition Rate and Recognition Confidence measures for the gestures that humans and robots expressed using different hand configurations. These experimental results indicate that most gestures are better recognized with a higher level of confidence when displayed with a posed robot hand. Guidelines and principles are provided based on these results for the mechanical design of robotic hands.
Applied Science, Faculty of
Mechanical Engineering, Department of
Graduate

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Bücher zum Thema "Hand1"

Hellmuth, Karasek. Hand in Handy. 2. Aufl. Hamburg: Hoffmann und Campe, 1997.

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Lucado, Max. One hand, two hands. Nashville: Tommy Nelson, 2010.

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Barbara, Kunz, Hrsg. Hand reflexology workbook: How to work on someone's hands. Englewood Cliffs, N.J: Prentice-Hall, 1985.

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Criscuolo, Neal. The hand book: The complete guide to reading hands. New York, N.Y: Dell Pub., 1995.

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Kunz, Kevin. Hand reflexology workbook: How to work on someone's hands. Albuquerque, NM: RRP Press, 1994.

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Howson, M. Patricia. Handy views: Radiographic positioning of the hand and wrist. Philadelphia: Lippincott-Raven, 1998.

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Vaughan, Marcia K. Hands, hands, hands. Greenvale, N.Y: Mondo Pub., 1995.

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Erwitt, Elliott. Elliott Erwitt's handbook. New York: Quantuck Lane Press, 2003.

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Gryski, Camilla. Hands on, thumbs up: Secret handshakes, fingerprints, sign languages, and more handy ways to have fun with hands. Reading, Mass: Addison-Wesley, 1991.

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Rodrigues, Larry. It's all in your hands: Hand analysis guidebook to self-understanding. 4. Aufl. Sacramento, CA: EastWest Institute for Self-Understanding, 1999.

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Buchteile zum Thema "Hand1"

van Dongen, Louise M., und Jan H. J. Pilon. „Goedaardige en kwaadaardige tumoren van pols en hand1“. In Handboek voor handrevalidatie, 89–99. Houten: Bohn Stafleu van Loghum, 2002. http://dx.doi.org/10.1007/978-90-313-9779-2_6.

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Otto, Daniela. „Handy, Handy in der Hand, wer ist die Schönste im ganzen Land?“ In Digital Detox, 99–105. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48967-3_10.

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Grenander, U., Y. Chow und D. M. Keenan. „Dealing with Highly Variable Patterns“. In Hands, 1–7. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3046-5_1.

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Grenander, U., Y. Chow und D. M. Keenan. „Pattern Synthesis“. In Hands, 8–38. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3046-5_2.

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Grenander, U., Y. Chow und D. M. Keenan. „Pattern Analysis“. In Hands, 39–44. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3046-5_3.

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Grenander, U., Y. Chow und D. M. Keenan. „Pattern Synthesis: Experiments“. In Hands, 45–54. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3046-5_4.

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Grenander, U., Y. Chow und D. M. Keenan. „Pattern Analysis — Experiments“. In Hands, 55–63. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3046-5_5.

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Grenander, U., Y. Chow und D. M. Keenan. „Model Critique and Conclusions“. In Hands, 65–66. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3046-5_6.

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Stahl, Neta. „“And You Will Hand Me into the Hands of Man”“. In The Divine in Modern Hebrew Literature, 121–52. Abingdon, Oxon ; New York, NY : Routledge, 2020. | Series: Routledge Jewish studies series: Routledge, 2020. http://dx.doi.org/10.4324/9781315688350-6.

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Narayanan, Gokul, Joshua Amrith Raj, Abhinav Gandhi, Aditya A. Gupte, Adam J. Spiers und Berk Calli. „Within-Hand Manipulation Planning and Control for Variable Friction Hands“. In Experimental Robotics, 600–610. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71151-1_53.

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Konferenzberichte zum Thema "Hand1"

Yang, Dongseok, BackSan Moon, Haneurl Kim und Younggeun Choi. „Synthetic Hands Generator for RGB Hand Tracking“. In TENCON 2018 - 2018 IEEE Region 10 Conference. IEEE, 2018. http://dx.doi.org/10.1109/tencon.2018.8650519.

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Palli, G., U. Scarcia, C. Melchiorri und G. Vassura. „Development of robotic hands: The UB hand evolution“. In 2012 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2012). IEEE, 2012. http://dx.doi.org/10.1109/iros.2012.6386303.

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Ma, Raymond R., Walter G. Bircher und Aaron M. Dollar. „Toward robust, whole-hand caging manipulation with underactuated hands“. In 2017 IEEE International Conference on Robotics and Automation (ICRA). IEEE, 2017. http://dx.doi.org/10.1109/icra.2017.7989158.

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Vinayak, Sundar Murugappan, Cecil Piya und Karthik Ramani. „Handy-Potter: Rapid 3D Shape Exploration Through Natural Hand Motions“. In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-71427.

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Annotation:

We present the paradigm of natural and exploratory shape modeling by introducing novel 3D interactions for creating, modifying and manipulating 3D shapes using arms and hands. Though current design tools provide complex modeling functionalities, they remain non-intuitive and require significant training since they segregate 3D shapes into hierarchical 2D inputs, thus binding the user to stringent procedural steps and making modifications cumbersome. In addition the designer knows what to design when they go to CAD systems and the creative exploration in design is lost. We present a shape creation paradigm as an exploration of creative imagination and externalization of shapes, particularly in the early phases of design. We integrate the capability of humans to express 3D shapes via hand-arm motions with traditional sweep surface representation to demonstrate rapid exploration of a rich variety of fairly complex 3D shapes. We track the skeleton of users using the depth data provided by low-cost depth sensing camera (Kinect™). Our modeling tool is configurable to provide a variety of implicit constraints for shape symmetry and resolution based on the position, orientation and speed of the arms. Intuitive strategies for coarse and fine shape modifications are also proposed. We conclusively demonstrate the creation of a wide variety of product concepts and show an average modeling time of a only few seconds while retaining the intuitiveness of communicating the design intent.

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Atzori, Manfredo, Arjan Gijsberts, Barbara Caputo und Henning Muller. „Natural control capabilities of robotic hands by hand amputated subjects“. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2014. http://dx.doi.org/10.1109/embc.2014.6944590.

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Liarokapis, Minas, und Aaron M. Dollar. „Deriving dexterous, in-hand manipulation primitives for adaptive robot hands“. In 2017 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS). IEEE, 2017. http://dx.doi.org/10.1109/iros.2017.8206014.

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Mattar, Ebrahim. „Biomimetic Dexterous Hands: Human Like Multi-fingered Robotics Hand Control“. In 2012 UKSim 14th International Conference on Computer Modelling and Simulation (UKSim). IEEE, 2012. http://dx.doi.org/10.1109/uksim.2012.35.

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Spiro, Ian, Graham Taylor, George Williams und Christoph Bregler. „Hands by hand: Crowd-sourced motion tracking for gesture annotation“. In 2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops (CVPR Workshops). IEEE, 2010. http://dx.doi.org/10.1109/cvprw.2010.5543191.

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Saraiji, MHD Yamen, Charith Lasantha Fernando, Kouta Minamizawa und Susumu Tachi. „Mutual hand representation for telexistence robots using projected virtual hands“. In AH '15: The 6th Augmented Human International Conference. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2735711.2735777.

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Kopuklu, Okan, Yao Rong und Gerhard Rigoll. „Talking With Your Hands: Scaling Hand Gestures and Recognition With CNNs“. In 2019 IEEE/CVF International Conference on Computer Vision Workshop (ICCVW). IEEE, 2019. http://dx.doi.org/10.1109/iccvw.2019.00345.

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Berichte der Organisationen zum Thema "Hand1"

Frye, Timothy, und Andrei Shleifer. The Invisible Hand and the Grabbing Hand. Cambridge, MA: National Bureau of Economic Research, Dezember 1996. http://dx.doi.org/10.3386/w5856.

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Morse, Rachel M. ISR All Hands. Office of Scientific and Technical Information (OSTI), Juli 2017. http://dx.doi.org/10.2172/1373511.

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Neumeister, Michael W., und Shaun D. Mendenhall. Hand Transplant. Touch Surgery Simulations, November 2015. http://dx.doi.org/10.18556/touchsurgery/2015.s0056.

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Goldman, Eitan, und Gary Gorton. The Visible Hand, the Invisible Hand and Efficiency. Cambridge, MA: National Bureau of Economic Research, März 2000. http://dx.doi.org/10.3386/w7587.

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Brown, J. David, John S. Earle und Scott G. Gehlbach. Helping Hand or Grabbing Hand? State Bureaucracy and Privatization Effectiveness. W.E. Upjohn Institute, August 2008. http://dx.doi.org/10.17848/wp08-142.

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BENNION, S. I. HANDI 2000 project execution plan. Office of Scientific and Technical Information (OSTI), September 1999. http://dx.doi.org/10.2172/797993.

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Papadimitriou, Spiros, Anthony Brockwell und Christos Faloutsos. Adaptive, Hands-Off Stream Mining. Fort Belvoir, VA: Defense Technical Information Center, Dezember 2002. http://dx.doi.org/10.21236/ada461108.

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Daum, Ing W. Approved Surgical Robot Hand. Fort Belvoir, VA: Defense Technical Information Center, Oktober 1995. http://dx.doi.org/10.21236/ada286841.

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Gasperikova, Erika. Hand-Held UXO Discriminator. Fort Belvoir, VA: Defense Technical Information Center, September 2010. http://dx.doi.org/10.21236/ada539243.

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Gasperikova, E., J. T. Smith, K. N. Kappler, A. Ratti, H. F. Morrison und A. Becker. Hand-held UXO Discriminator. Office of Scientific and Technical Information (OSTI), April 2010. http://dx.doi.org/10.2172/979910.

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