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1

Chen, Shih-Yin Maciejewski Matthew Leonard. „Second-generation antidepressant use in treatment for major depressive disorder an examination of guideline components and healthcare utilization /“. Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2098.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.
Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Division of Pharmaceutical Outcomes and Policy in the School of Pharmacy." Discipline: Pharmaceutical Outcomes and Policy; Department/School: Pharmacy.
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Elwing-Malmfelt, Linus, und Oscar Keresztes. „Semi-automated hardening of networks based on security classifications“. Thesis, Blekinge Tekniska Högskola, Institutionen för datavetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-21793.

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Conducting risk assessments is a vital part of securing information systems. The task of conducting risk assessments is a time-consuming and costly task for organizations. Thus different security control frameworks have been created to assist in the process. These security control frameworks consists of information about what the organization is supposed to implement to achieve a level of security in their information system. To understand what network hardening solution to use and in what part of the system, an analyst needs to manually use the implementation details gathered from the framework. A security control can be split into different security tiers depending on the amount of security the implementation achieves. The security tiers are defined by the authors of the security control framework. An organization can reduce their cost and time spent on implementing the security by having a tool that parses the information system and creates guidelines based on security controls and parsed data. In this research, we will compare different security controls and based on the findings, investigate hardware, software and configurations that are being used when conducting network hardening. We will evaluate to which extent it is possible to generate guidelines that meet the given security tier, whether it is feasible to apply them and present a prototype that is able to generate guidelines. The different security controls will be compared by analyzing the contents of each control in the frameworks. A comprehensive mapping will be created and based on the information gathered in the mapping, network-hardening implementations will be investigated based on the devices in our experiment environment. With implementations at hand, a tool will be proposed that parses information systems and outputs guidelines that integrate the implementations in a readable format. Experts within the field of system hardening then evaluate the created guidelines in terms of achieving defined security levels. For the comparison, a total of 148 different controls were identified to be related in some way. With 148 controls at hand, the prototype can output 111 different guidelines with different security tier associations. According to the comments from the experts, the proposed guidelines were able to satisfy each security tier. Our prototype displayed that we were able to create guidelines that can meet a given security tier. Although the implementation of each guideline is not automated, identifying what network-hardening implementation should be used is done in an automated fashion and thus allowing organizations to put their spending and time into other organizational interests. \newline
Att utföra riskbedömningar är en nödvändig process när ett informations-system ska säkras. Uppgiften med att utföra riskbedömningar är för organisationer en tidskrävande och dyr process. Därför har olika ramverk för säkerhetskontroller tagits fram för att underlätta denna uppgift. Dessa ramverk innehåller information över vad en organisation behöver implementera för att erhålla en specifik nivå av säkerhet i deras informations-system. Den här säkerhetsnivån varierar beroende på hur mycket säkerhet en implementation tillför. De olika nivåerna definieras av ramverksförfattarna. För att förstå vilka nätverkshärdningar organisationen ska använda samt för vilken del i systemet dessa härdningar ska appliceras, behöver en analytiker manuellt gå igenom implementerings-lösningar i ramverken tillsammans med systemet och på så vis ta fram korrekt härdningsåtgärd för en specifik del i systemet. Syftet med arbetet är att jämföra olika säkerhetskontroller och baserat på resultatet undersöka hur hårdvara, mjukvara och konfigurationer kan användas för att härda nätverket. Vi kommer att utvärdera i vilken utsträckning det är möjligt att generera riktlinjer, huruvida det är möjligt att applicera riktlinjerna och ta fram en prototyp som kan generera riktlinjer. De olika ramverken kommer att jämföras genom att innehållet i deras säkerhetskontroller analyseras. En omfattande mappning kommer att tas fram baserat på analysen och utifrån mappningen kommer ytterliggare implementationer rörande nätverkshädrning analyseras. Med hjälp av implementationerna kommer ett verktyg att föreslås vilket analyserar ett informations-system och som producerar riktlinjer som integrerar implementationerna till ett läsbart format. Dessa riktlinjer undersöks sedan av experter gällande hur väl riktlinjerna uppnår definerade säkerhetsnivåer. Under arbetet identifierades totalt 148 olika säkerhets-kontroller som påvisade likhet med varandra. Med dessa 148 kontroller tillgodo klarade vår prototyp av att producera 111 olika riktlinjer tillhörande olika säkerhetsnivåer beroende på systemet som matades in. Enligt kommentarerna ur granskningen som experterna utförde gick följande att konstatera: riktlinjerna som tas fram genom prototypen kunde upprätthålla varje säkerhetsnivå. Vår prototyp påvisade att det var möjligt att skapa riktlinjer som uppnår en efterfrågad säkerhetsnivå. Även om implementering för varje producerad riktlinje inte är automatiserad så kunde vår prototyp automatisera processen av att avgöra vilken nätverks-härdnings implementation som skulle användas för var riktlinje. Detta tillåter organisationer att lägga mer tid och investeringar i andra organisatoriska intressen.
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Wintergerst, Eike [Verfasser], und A. [Akademischer Betreuer] Albers. „Leitfaden zur deduktiven Gestaltvariation durch Ermittlung der funktionsbestimmenden Stellgrößen in der Produktgenerationsentwicklung = Guideline for deductive design variation by determination of the relevant parameters in product generation development [[Elektronische Ressource]] / Eike Wintergerst. Betreuer: A. Albers“. Karlsruhe : KIT-Bibliothek, 2015. http://d-nb.info/1074463684/34.

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SILVA, Cledja Karina Rolim da. „Design guidelines for generating augmented reality instructions“. Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/25074.

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Most work about instructions in Augmented Reality do not follow established patterns or design rules – each approach defines its own method for conveying instructions. This work describes our results and experiences towards defining design guidelines for Augmented Reality instructions. From these guidelines, we propose a set of instructions and empirically validate them. The guidelines were derived from a survey of the most common visualization techniques and instruction types applied in Augmented and Mixed Reality. Moreover, we studied how instructions were done in 2D and 3D and how they can be applied in the Augmented Reality context. We observed that most work is related to object instructions and less work to body movement instructions. However, our proposal can be used in both cases. To validate our proposal we implemented a C⁺⁺ system, which -can be seen as a library to be used in different kinds of environments where the instructions of body and objects movements are important. A RGB-D sensor was applied to capture the movements. As result, we had visualization techniques applied together with typical AR instructions and indications of what kind of instruction could be used to: emphasize parts, indication of direction of the movement, management of occlusion, management of depth and feedback.
Grande parte de trabalhos relacionados a instruções em Realidade Aumentada não segue padrões ou guias de desenvolvimento – cada abordagem define seu modo próprio de transmitir instruções. Este trabalho descreve nossos resultados e experiência na direção de definir guias de desenvolvimento ou projeto para aplicações que utilizem Realidade Aumentada. A partir dessas guias de desenvolvimento, propomos um conjunto de instruções e empiricamente validamos as mesmas. Essas guias foram derivadas de uma pesquisa extensiva sobre as técnicas de visualização e instruções relacionadas à Realidade Aumentada e Mista. Além disso, verificamos trabalhos sobre instruções 2D e 3D para entender o funcionamento desta área para checar como e que tipo de informação poderia ser adaptada e usada no contexto de aplicações para Realidade Aumentada. Observamos que a maioria dos trabalhos é relacionada a instruções com objetos e há poucos trabalhos relacionados a instruções de movimentos do corpo. Para validar nossa proposta, implementamos um sistema em C⁺⁺, o qual tem o objetivo de ser uma biblioteca para ser usada em diferentes tipos de ambientes ou contextos onde instruções de movimento do corpo sejam importantes. Para capturar o movimento do corpo, um sensor RGB-D foi utilizado. Como resultado, apresentamos técnicas de visualização aplicadas com instruções comuns em Realidade Aumentada e indicação de que tipo de instrução pode ser usada para: realçar partes, indicação da direção do movimento, gerenciamento de oclusão, gerenciamento de profundidade e retorno para o usuário.
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Anwar, A. H. M. Mehbub. „Trip generation models for Khulna City of Bangladesh: a transport planning guidelines perspective“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B3126119X.

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Tincup, Michal Grissett 1969. „The generation of design and planning guidelines for a new southwestern community“. Thesis, The University of Arizona, 1997. http://hdl.handle.net/10150/291408.

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As our southwestern cities continue to grow in essentially uncontrolled and sprawling patterns it becomes increasingly apparent that new planning approaches and design guidelines must be generated to rectify past and combat future problems. Today, many community developments focus decision making principles on purely economic gain at the expense of addressing the socio-cultural, aesthetic, functional, economic, and environmental issues. In an attempt to address these issues, we employed both qualitative and quantitative methods of research. The qualitative methods included: a case study analysis of past, present and future communities; a literature review of past communities and new theoretical movements; structured interviews with real estate developers in the southwest; and participant observation encompassing peer dialogue and design reviews. The quantitative methods included statistical analysis of questionnaires given to designers and developers practicing in the southwest. A series of design and planning guidelines were distilled from this research. They were then tested by applying them to the design of a new community in the southwestern United States.
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Johnson, David Michael 1960. „Environmental design guidelines for a second generation, LEO, permanently manned space station“. Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/74786.

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Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1987.
MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.
Includes bibliographical references (pages 107-109).
This thesis is a continuation of the thoughts and efforts of the author's participation and co-organization of the Space Station Design Workshop (SSDW). The SSDW was a student run event whose inception surfaced in the Spring of 1986, materialized over the summer of that year, and subsequently "launched" itself in the Fall term. The emphasis of the SSDW was on the development and design of a deployable truss system which would be transported in, and deployed from, the cargo bay of the space shuttle. The design emphasis on deployability over an erectable system was based upon the former's lower construction overh~ the creation of "instant real estate", and the inherent lower Extravehicular Activity (EVA) time resulting in a higher margin of crew safety. This thesis is a continuation of the groundwork laid by the SSDW into the design criteria and implementation strategy for the living habitat of a six man Space Station. The scope of the thesis can be summarized in its six sections: 1. A study of appropriate space station analogs with a presentation of conclusions and recommendations based upon the findings. 2. A study of the anthropometrics of the human body in a zero-gravity environment with a presentation of conclusions and recommendations based upon the findings. 3. A study of the physiological effects of zero-gravity on the human body with a presentation of conclusions and recommendations based upon the findings. 4. A study of three strategies of interior module design with a presentation of conclusions and recommendations based upon the findings. 5. A presentation of the the current NASA Space Station art as a basis of comparative study to this thesis' proposed design. 6. A presentation of a complete space station design proposal and implementation strategy based upon recommendations of the preceeding studies.
by David Michael Johnson.
M.S.
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Päärni, Anna. „Designing a Voice Controlled Interface For Radio : Guidelines for The First Generation of Voice Controlled Public Radio“. Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136894.

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From being a fictional element in sci-fi, voice control has become a reality, with inventions such as Apple's Siri, and interactive voice response (IVR) when calling your doctor's office. The combination of radio’s strength as a hands-free medium, public radio’s mission to reach across all platforms and the rise of voice makes up a relevant intersection; voice controlled public radio in Sweden. This thesis has aimed to investigate how radio listeners wish to interact using voice control to listen to on-demand radio content. Additionally, what does public radio need to consider when implementing the UX for voice control? A questionnaire, Google Analytics-data from Sveriges Radio’s mobile app and website, and an interview with National Public Radio were used to determine four initial functions voice controlled on-demand. The functions were turned into four scenarios, used as the basis for a workshop and brainstorming session. Three of these scenarios were then selected to be the foundation for a Wizard of Oz-prototype, which six users evaluated. The results indicate that to create a viable voice user interface (VUI) for radio, there needs to be a profile for the user to create a personalized experience, with filtered searches created by user behaviour and preference settings. The VUI also needs to allow synonyms for program names, as well as keyword tag material for clustering similar material and to enable personalized user searches. This keyword-system can further be utilized to give user recommendations based on behaviour and preferences. A companion application with a graphical user interface (GUI) can be used for such functionality as settings, help, queuing and creating playlists. Finally, the system needs to ensure that the users are taken care of and guided. A radio host can be used as a basis for the system's persona, to create a consistent and familiar interface. Aspects to examine in the future are more extensive user testing for the VUI design, filter bubbles, ensuring that the user data is not misused or leaked, dimensions of the system's persona, the future of radio and the progress of IPAs.
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Rodler, Helmut. „Next generation ship-borne ASW-system: an exemplary exertion of methodologies and tools applied according to the German military acquisition guidelines“. Monterey, California: Naval Postgraduate School, 2013. http://hdl.handle.net/10945/34730.

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The German Armed forces acquisition guideline, the Customer Product Management (CPM), regulates the principal acquisition process steps including the responsibilities between civil and military departments. Many of the CPMs specified deliverables, like formulating needs, writing requirements and conducting analysis, are created and managed by military personnel that are assigned to support the acquisition management. These military personnel are not always familiar with the common systems engineering and acquisition methodologies and tools. The capabilities of the German armed forces are derived based on missions and tasks. The variation and number of needed capabilities leads to a greater likelihood of risk, threat and funding. ASW missions currently are no longer considered primary capabilities of the German Navy. The ASW ships in service cannot accommodate the future ASW helicopter (MH90), which will cause the loss of utilization of this primary warfighting ASW sensor and weapon. On the other hand ships without any ASW capabilities, like the F125, can accommodate ASW helicopters. This dilemma is still unresolved by naval leaders. This thesis shall examine the German basic acquisition guidelines and present applicable systems engineering methodologies and tools considering existing regulations. A basic systems engineering process will be demonstrated using a possible German Navy next generation ship-borne ASW-system through the presented methodologies.
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Camplin, Giles. „Rediscovering the arcane science of ground handling large airships : an investigation into ways of reducing the risks inherent in the development of a new generation of very large airships and of establishing guidelines for their ground handling procedure“. Thesis, City University London, 2007. http://openaccess.city.ac.uk/8521/.

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This research, which was begun as part of the now defunct CargoLifter project, concerns the ground handling and support systems of the large rigid airships (commonly known as "Zeppelins") that were built between 1900 and 1940. The intention was to assess the value of such historical information as has survived from the previous generation of very large airships in order to minimise the physical and financial risks inherent in the development of any future generations of such aircraft. The idea was to isolate and understand the fundamental issues that were actually encountered by the ground based personnel responsible for looking after the various British, German, American and Italian airships of the previous generation, and to gather as much information as possible about the techniques and operational procedures that were devised, tried and tested in the field. This information would then be used to establish guidelines for future projects that are based on real experience rather than on prediction, assumption or theory. Sadly, the CargoLifter project foundered in 2002; however the author had by then amassed sufficient research material for him to complete the study independently and to present it as a guide for the ground handling of hitherto unrealised concepts such as the proposed new "Transport category" or "CargoLifter" type large airships. Such practical skills as those required by airship ground crew personnel are normally passed on by firsthand instruction from one experienced practitioner to the trainee. This option is not available for the next generation of very large airships because there are no personnel alive today with any operational experience of the previous generation of really large airships. The problem therefore is to examine the historical records and to evaluate the written information in order to interpret it and pass on knowledge that will reduce the risk of future generations wasting their time in "re-inventing the wheel. " In the course of the study it was found that historical research (HR) enabled the results of the pre-war prototype projects to be usefully assessed despite the fact that very little of the material was written with that end in view. More specifically the analysis of historical airship activities (AHAA) revealed that it was possible to retrieve a considerable amount of lost or forgotten knowledge concerning the ground handling of very large airships, also to unearth ideas that were ahead of their time, which might be applicable today or in the future; and in addition to identify several areas worthy of further investigation (e. g. ideas that were rejected at the time but which may now be feasible due to technological progress). The research and analysis also uncovered some ideas and suggested solutions which are fundamentally flawed and that should be avoided by designers of large airships and their support systems. The work includes a detailed analysis of the tasks involved in the ground handling of very large airships and concludes with a suggested strategy for all those intent upon the design and planning of ground support infrastructures for any further large airship development projects either today or in the future.
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Dannecker, Lars. „Visualisierung von Service-Frontends in einem Werkzeug zur präsentationsorientierten Komposition annotierter Dienste“. Master's thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-25352.

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Das Ziel des ServFace Projektes ist es Endnutzern ohne umfangreiche IT-Kenntnisse das einfache Erstellen von servicebasierten Anwendungen zu ermöglichen. Dazu wird ein Kompositions- werkzeug mit dem Namen “ServFace Builder“ verwendet. Das Werkzeug erlaubt es Endnutzern, interaktive Anwendungen durch die Komposition von Service-Operationen zu erstellen. Dafür ist eine grafische Repräsentation der Service-Operationen durch UI-Fragmente notwendig. Die UI-Fragmente werden im ServFace-Umfeld als Frontends bezeichnet. In der vorliegenden Arbeit wird ein Konzept zur automatischen Visualisierung dieser Frontends vorgestellt. Um das Ergebnis der Visualisierung zu verbessern, nutzt der Visualisierungsprozess neben der Service-Beschreibung weitere Informationen in Form von Annotationen und Gestaltungsempfehlungen. Konkret werden die folgenden Aspekte in dieser Arbeit beschrieben: • Visualisierung von Frontends zur Repräsentation von Service-Operationen auf Basis von Service-Beschreibungen, Annotationen, Plattformspezifikationen und Gestaltungsempfehlungen unter der Maßgabe der Gebrauchstauglichkeit und Nutzbarkeit. • Integration der Frontends in die jeweils aktuelle Instanzen des gegebenen Anwendungsmodells. • Technische Umsetzung und Evaluation der entwickelten Konzepte
The aim of the ServFace Project is to enable users with limited IT skills to easily create service-based applications. In order to do so, a tool called "ServFace Builder" has been developed. This tool allows users to build a composite application by combining several service operations. An important part of the ServFace Builder is the graphical representation of those service operations through user interfaces. This thesis describes an approach to automatically generate user interfaces for service operations. To enhance the graphical representation, the user interface generation process of the ServFace Builder comprises annotations and design recommendations next to the common service descriptions to enhance the result of the generation process. This thesis discusses: • Graphical representation of service operations on the basis of service descriptions, annotations, plattform specifications and design recommendations. • Integration of the graphical representation into the actual instance of the given application model. • Implementation and evaluation of the presented concepts
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(7023350), Amber M. Johnson. „Generating Evidence for COPD Clinical Guidelines Using EHRs“. Thesis, 2019.

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The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelinesare used to guide clinical practices for treating Chronic Obstructive Pulmonary Disease (COPD). GOLD focuses heavily on stable COPD patients, limiting its use fornon-stable COPD patients such as those with severe, acute exacerbations of COPD (AECOPD) that require hospitalization. Although AECOPD can be heterogeneous, it can lead to deterioration of health and early death. Electronic health records (EHRs) can be used to analyze patient data for understanding disease progression and generating guideline evidence for AECOPD patients. However, because of its structure and representation, retrieving, analyzing, and properly interpreting EHR data can be challenging, and existing tools do not provide granular analytic capabil-ities for this data.

This dissertation presents, develops, and implements a novel approach that systematically captures the effect of interventions during patient medical encounters, and hence may support evidence generation for clinical guidelines in a systematic and principled way. A conceptual framework that structures components, such as data storage, aggregation, extraction, and visualization, to support EHR data analytics for granular analysis is introduced. We develop a software framework in Python based on these components to create longitudinal representations of raw medical data extracted from the Medical Information Mart for Intensive Care (MIMIC-III) clinical database. The software framework consists of two tools: Patient Aggregated Care Events (PACE), a novel tool for constructing and visualizing entire medical histories of both individual patients and patient cohorts, and Mark SIM, a Markov Chain Monte Carlo modeling and simulation tool for predicting clinical outcomes through probabilistic analysis that captures granular temporal aspects of aggregated, clinicaldata.

We assess the efficacy of antibiotic treatment and the optimal time of initiationfor in-hospitalized AECOPD patients as an application to probabilistic modeling. We identify 697 AECOPD patients of which 26.0% were administered antibiotics. Our model simulations show a 50% decrease in mortality rate as the number of patients administered antibiotics increase, and an estimated 5.5% mortality rate when antibiotics are initially administrated after 48 hours vs 1.8% when antibiotics are initially administrated between 24 and 48 hours. Our findings suggest that there may be amortality benefit in initiation of antibiotics early in patients with acute respiratory failure in ICU patients with severe AECOPD.

Thus, we show that it is feasible to enhance representation of EHRs to aggregate patients’ entire medical histories with temporal trends and support complex clinical questions to drive clinical guidelines for COPD.
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Telenko, Cassandra. „Developing green design guidelines: a formal method and case study“. Thesis, 2009. http://hdl.handle.net/2152/ETD-UT-2009-12-591.

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This thesis describes and demonstrates a method for consolidating, developing, and using green design guidelines for the innovation of greener products. Life cycle analysis (LCA) is one well-accepted tool for quantifying the environmental impacts of a product so designers can identify areas for redesign effort. However, LCA is a retrospective design tool that requires detailed design information that isn’t known until designs are near completion. Alternatively, green design guidelines provide proven techniques for designing greener products. They can be used during the early stages of design, when many decisions fundamental to innovation and environmental impact are made and before LCA is viable. This thesis extends the work already done in green design guidelines, by updating the current knowledge base and introducing a method for extending the set of existing guidelines to encompass new and emerging areas of sustainability. While guidelines have been created from prior experience in design for environment and life cycle analysis, they have not been maintained as a shared and coordinated repertoire of green design solutions. Instead, sets of guidelines are scattered throughout the literature, contain overlaps, operate at different levels of abstraction, and have varying levels of completeness. For example, some areas of green design guidelines, such as design for disassembly, are well established, while other areas of green design guidelines, such as minimizing energy consumption during use, are still being explored. Additionally, while numerous examples of green design guidelines exist, many of the guidelines have no documented validation of their life cycle impacts. The work for this thesis began with the compilation of a dynamic knowledge base of green design guidelines. This set of guidelines is a consolidation and updating of the green design guidelines already available in literature and can be used as a starting poinrt for future improvements and extensions as the field develops. A standard method was then proposed and tested for creating guidelines in currently undeveloped areas of green design, particularly energy consumption during the operation of a product. The method employs reverse engineering techniques and life cycle analysis to identify green requirements and develop corresponding, new green design guidelines. A case study of electric kettles demonstrated the usefulness of the method by yielding four new guidelines and four, corresponding, energy saving re-designs. For this example, the redesigns showed that guidelines can reduce energy consumption, but may incur tradeoffs with other life cycle stages. Calculation of tradeoffs revealed a range of net life cycle impact values that were caused by increased manufacturing demands and variability in consumer use habits. In addition to redesign in the kettle study, the four new guidelines were tested for usefulness in new product design by use of focus groups. Two groups were tasked with designing a new energy efficient toaster concept. Only one group was given the four green design guidelines that were uncovered using the proposed method. The design group using the new green design guidelines produced more viable and practical green features than the design group that did not have the guidelines as a design tool. These preliminary results suggest that the proposed method is useful for creating new guidelines that are beneficial to design teams tackling novel design problems that differ from the original case study. Further work is needed to establish the statistical significance of these results.
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Dannecker, Lars. „Visualisierung von Service-Frontends in einem Werkzeug zur präsentationsorientierten Komposition annotierter Dienste“. Master's thesis, 2009. https://tud.qucosa.de/id/qucosa%3A25160.

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Das Ziel des ServFace Projektes ist es Endnutzern ohne umfangreiche IT-Kenntnisse das einfache Erstellen von servicebasierten Anwendungen zu ermöglichen. Dazu wird ein Kompositions- werkzeug mit dem Namen “ServFace Builder“ verwendet. Das Werkzeug erlaubt es Endnutzern, interaktive Anwendungen durch die Komposition von Service-Operationen zu erstellen. Dafür ist eine grafische Repräsentation der Service-Operationen durch UI-Fragmente notwendig. Die UI-Fragmente werden im ServFace-Umfeld als Frontends bezeichnet. In der vorliegenden Arbeit wird ein Konzept zur automatischen Visualisierung dieser Frontends vorgestellt. Um das Ergebnis der Visualisierung zu verbessern, nutzt der Visualisierungsprozess neben der Service-Beschreibung weitere Informationen in Form von Annotationen und Gestaltungsempfehlungen. Konkret werden die folgenden Aspekte in dieser Arbeit beschrieben: • Visualisierung von Frontends zur Repräsentation von Service-Operationen auf Basis von Service-Beschreibungen, Annotationen, Plattformspezifikationen und Gestaltungsempfehlungen unter der Maßgabe der Gebrauchstauglichkeit und Nutzbarkeit. • Integration der Frontends in die jeweils aktuelle Instanzen des gegebenen Anwendungsmodells. • Technische Umsetzung und Evaluation der entwickelten Konzepte
The aim of the ServFace Project is to enable users with limited IT skills to easily create service-based applications. In order to do so, a tool called "ServFace Builder" has been developed. This tool allows users to build a composite application by combining several service operations. An important part of the ServFace Builder is the graphical representation of those service operations through user interfaces. This thesis describes an approach to automatically generate user interfaces for service operations. To enhance the graphical representation, the user interface generation process of the ServFace Builder comprises annotations and design recommendations next to the common service descriptions to enhance the result of the generation process. This thesis discusses: • Graphical representation of service operations on the basis of service descriptions, annotations, plattform specifications and design recommendations. • Integration of the graphical representation into the actual instance of the given application model. • Implementation and evaluation of the presented concepts.
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Jazi, Sarra. „Étude rétrospective sur l’adhésion aux lignes directrices canadiennes (CAMESA) de monitoring des effets métaboliques des antipsychotiques de seconde génération chez les enfants et les adolescents“. Thesis, 2020. http://hdl.handle.net/1866/24495.

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Les antipsychotiques de seconde génération (ASG) peuvent induire des effets métaboliques tels qu’une prise de poids, des troubles cardio-métaboliques, des effets endocriniens et dans de très rares cas une mort soudaine d’origine cardiaque. Les effets indésirables métaboliques potentiels des ASG doivent être surveillés. L’Alliance canadienne pour la surveillance de l’efficacité et de l’innocuité des antipsychotiques (CAMESA) propose des lignes directrices à cet effet. Les objectifs de cette étude rétrospective sont d’évaluer, à long terme, les taux d’enfants et d’adolescents recevant pour la première fois un ASG bénéficiant d’un monitoring dans les cliniques de santé mentale et de documenter les facteurs qui peuvent les influencer. À cet effet, les dossiers médicaux de 180 enfants et adolescents (âge moyen 13,3 ± 3,1 ans, 54,4 % garçons), traités pour la première fois par ASG entre janvier 2016 et juin 2018, ont été examinés. Les périodes de monitoring ont été divisées en baseline, de 1 à 6 et de 9 à 24 mois. La population étudiée a été stratifiée en enfants (4- 12 ans) vs adolescents (13-18 ans). Les caractéristiques sociodémographiques, le diagnostic psychiatrique et les comorbidités, les types d’ASG et les comédications prescrites, les mesures anthropométriques (MA), la pression artérielle (PA), les bilans sanguins (BS), l’électrocardiogramme (ECG) et les années de pratique du psychiatre ont été collectés. Des tableaux croisés ont été utilisés pour présenter les taux de monitoring. Les catégories ont été comparées par analyse de co-variable. Les taux de patients monitorés ont été comparés à travers les catégories de monitoring, en ayant recours au test exact de Fisher. Nos résultats démontrent des taux de monitoring pour MA, BS et PA de : 55 %, 47,8 % et 46,7 % au baseline ; 50 %, 41,7 % et 45,2 % à 1-6 mois ; et 47,2 %, 41,5 % et 40,6 % à 9-24 mois, respectivement. Des taux de monitoring plus élevés étaient associés de manière significative au statut d’adolescent (MA, BS et PA au baseline ; MA et PA à 1-6 mois), à un diagnostic de trouble psychotique et / ou affectif (MA, BS et PA au baseline ; MA et PA à 1-6 mois; BS à 9-24 mois), avoir ≤ 1 comorbidités psychiatriques (BS à 1-6 mois), et à l’expérience du clinicien (BS et ECG à 1-6 mois). En conclusion, cinq ans après les recommandations de CAMESA, le monitoring métabolique est effectué chez moins de la moitié des patients et diminue tout au long de la durée du traitement. Dans notre échantillon, les catégories d’âge, de diagnostic, de comorbidités psychiatriques et d’expérience du clinicien ont influencé les taux de monitoring. Toutefois, des progrès importants doivent encore être réalisés pour parvenir à un taux de monitoring satisfaisant.
Second generation antipsychotics (SGA) can induce metabolic effects such as weight gain, cardiometabolic disorders, endocrine effects and in very rare cases sudden cardiac death. The potential metabolic side effects of second generation antipsychotics need to be monitored. The Canadian Alliance for Monitoring the Efficacy and Safety of Antipsychotics (CAMESA) offers guidelines for this purpose. The objectives of this retrospective study are to evaluate, the long-term rates of youths receiving monitoring in mental health clinics and document the factors that may influence them. To this end, the charts of 180 children and adolescents (average age 13.3 ± 3.1 years, 54.4 % males) receiving SGA treatment for the first time between January 2016 and June 2018 were reviewed. Monitoring was divided into baseline and 1 to 6 and 9 to 24-month periods. The population under study was stratified into children (4-12 years) vs adolescents (13-18 years). Sociodemographic characteristics, psychiatric diagnosis and comorbidities, prescribed SGAs and comedications, anthropometric measurements (AM), blood pressure (BP), blood tests (BT), electrocardiogram (ECG) and the psychiatrist’s years of practice were collected. Cross tables were used to present the monitoring rates. Categories were compared by covariate analysis. Rates of patients monitored across categories were compared using Fisher’s exact test. Our results show that monitoring rates for AM, BT, and BP were: 55 %, 47.8 %, and 46.7 % at baseline, 50 %, 41.7 %, and 45.2 % at 1 to 6 months, and 47.2 %, 41.5 %, and 40.6 % at 9 to 24 months, respectively. Higher monitoring rates were significantly associated with adolescent status vs child (baseline AM, BT, and BP; 1-6-month AM and BP), a diagnosis of psychotic and/or affective disorder (baseline AM, BT, and BP; 1-6-month AM and BP; 9-24-month BT), having ≤ 1 psychiatric comorbidities (1-6-month BT), and clinician’s experience (1-6-month BT and ECG). In conclusion, five years after publication of the CAMESA guidelines, metabolic monitoring is conducted for less than half of patients and decreases over time. In our sample, age, diagnostic category, psychiatric comorbidities, and clinician’s experience influenced the monitoring rates. Major progress still needs to be made before reaching a satisfactory level of monitoring.
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