Dissertationen zum Thema „Genetic of cancer“
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Michael, Agnieszka. „Genetic immunotherapy for cancer“. Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437318.
Der volle Inhalt der QuelleSingh, Rashmi. „Genetic predisposition to prostate cancer“. Thesis, Institute of Cancer Research (University Of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416575.
Der volle Inhalt der QuelleSkoglund, Johanna. „Genetic studies of colorectal cancer /“. Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-098-5/.
Der volle Inhalt der QuelleWiklund, Fredrik. „Genetic epidemiology of prostate cancer“. Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-281.
Der volle Inhalt der QuelleLutke, Holzik Martijn Frederik. „Genetic predisposition to testicular cancer“. [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/304254797.
Der volle Inhalt der QuelleGonzález-Zuloeta, Ladd Angela Maria. „Genetic determinants of breast cancer“. [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10525.
Der volle Inhalt der Quelle黎子韻 und Tsz-wan Kristi Lai. „Genetic polymorphisms in ovarian cancer“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970618.
Der volle Inhalt der QuelleCheung, Chin-ling, und 張展寧. „Genetic analysis of nasopharyngeal cancer“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659866.
Der volle Inhalt der QuelleCheng, Timothy. „Genetic susceptibility to endometrial cancer“. Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:3a559ae0-156f-48a2-a64e-b03a13c562df.
Der volle Inhalt der QuelleLai, Tsz-wan Kristi. „Genetic polymorphisms in ovarian cancer“. Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25176493.
Der volle Inhalt der QuelleKho, Pik Fang. „Genetic epidemiology of endometrial cancer“. Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/211383/1/Pik%20Fang_Kho_Thesis.pdf.
Der volle Inhalt der QuelleSotheran, Wendy. „Genetic predisposition to breast cancer in selected individuals in Guernsey“. Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264721.
Der volle Inhalt der QuelleTai, Lai-shan, und 戴麗珊. „Molecular genetic characterizations of human non-small cell lung cancer“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31375315.
Der volle Inhalt der QuelleMarsh, Howard Piers. „Genetic polymorphisms in bladder cancer angiogenesis“. Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428513.
Der volle Inhalt der QuelleQuan, Xiaojiang. „Genetic study of mammary cancer development“. Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211503.
Der volle Inhalt der QuelleZhou, ZiaoLei. „Molecular genetic studies of colorectal cancer /“. Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-489-9/.
Der volle Inhalt der QuelleHasmats, Johanna. „Analysis of genetic variations in cancer“. Doctoral thesis, KTH, Genteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-104438.
Der volle Inhalt der QuelleQC 20121105
Ilyas, Mohammad. „The genetic basis of colorectal cancer“. Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301849.
Der volle Inhalt der QuelleLubbe, Steven John. „The genetic epidemiology of colorectal cancer“. Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538696.
Der volle Inhalt der QuelleLancaster, Johnathan Mark. „Molecular genetic etiology of ovarian cancer“. Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55576/.
Der volle Inhalt der QuelleReles, Angela. „Molecular genetic alterations in ovarian cancer“. Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13801.
Der volle Inhalt der QuelleObjective: The p53 tumor suppressor gene plays a central role in cell cycle regulation and induction of apoptosis. MDM2, the protein of the mdm2 gene, binds to p53, inhibits its transcriptional activity and promotes nuclear export and rapid degradation of the p53 protein. Methods: Frozen tissue of 178 ovarian carcinomas was analyzed for mutations of the p53 gene (exons 2-11) and p53 overexpression by SSCP (Single Strand Conformation Polymorphism), DNA-sequencing and immunohistochemistry. 92 cases of ovarian cancer, nine borderline ovarian tumors, six cystadenomas and 20 normal ovarian tissues were analyzed for mdm2 alternative RNA splicing by reverse transcription of total RNA, nested PCR amplification of mdm2 cDNAs and DNA sequencing of RT-PCR products. Results: p53 mutations were found in 56% (99/178) and p53 protein overexpression in 62% (110/178) of the tumors. Time to progression and overall survival were significantly shortened in patients with p53 mutations compared to wildtype p53 (p=0.029 and p=0.014). Resistance to adjuvant Cis- or Carboplatin chemotherapy was significantly more frequent in patients with p53 overexpression (p=0.001) or p53 missense mutations (p=0.008) than patients with normal p53. mdm2 RNA splicing was seen in 66/92 (72%) of the ovarian carcinomas, 7/9 (78%) of borderline tumors, 5/6 (83%) of benign cystadenomas and 11/20 (55%) of the normal ovarian tissues. A total of 30 splice variant sequences were identified, out of which 22 had a partial or complete loss of the p53 binding site. 28/30 do not splice at exon/intron boundaries and were therefore considered aberrant splice variants. The mdm2b splice variant of 654 bp, which splices out most of the p53 binding domain, was expressed in 41% of ovarian carcinomas, but only in 1/9 (11%) LMP tumors, and 1/20 (5%) of the normal ovaries. Expression of mdm2b in ovarian carcinomas was significantly correlated with poor grade of differentiation (p=0.004), residual tumor after surgery (p=0.004), high S-phase fraction (p=0.016) and p53 protein overexpression (p=0.018). A small splice variant of only 221 bp was present in only 16% of the ovarian carcinomas, but 56% of borderline tumors, and 40% of normal ovarian tissues and was correlated with early stage of ovarian cancer (p=0.017) and longer overall survival (p=0.048). Conclusion: p53 alterations correlate significantly with resistance to platinum-based chemotherapy, early relapse and shortened overall survival in ovarian cancer patients in univariate analysis. In multivariable analysis though, p53 was not an independent prognostic factor. mdm2 alternative and aberrant splicing was found frequently in ovarian tumors but also in normal ovarian tissue. While expression of the mdm2b splice variant was associated with histologically more aggressive ovarian carcinomas, smaller size variants were typically seen in early stage ovarian carcinomas and benign tissues. mdm2 alterations may stabilize p53 protein and cause p53 accumulation in the absence of p53 mutation in ovarian tumors.
Hayat, Roshanai Afsaneh. „Psychological and Behavioral Aspects of Receiving Genetic Counseling for Hereditary Cancer“. Doctoral thesis, Uppsala universitet, Vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128870.
Der volle Inhalt der QuelleChen, Lina. „Genetic epidemiology of Prostate Cancer : a genetic approach to identifying casual modifiable risk factors for prostate cancer“. Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627980.
Der volle Inhalt der QuelleUpstill-Goddard, Rosanna. „Genetic dissection of early-onset breast cancer and other genetic diseases“. Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/386938/.
Der volle Inhalt der Quelle陳安安 und On-on Annie Chan. „Methylation in colorectal cancer“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B25256312.
Der volle Inhalt der QuelleDjureinovic, Tatjana. „Investigation of genetic factors involved in colorectal cancer predisposition /“. Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-864-9/.
Der volle Inhalt der QuelleYoung, Alison Luk. „Next generation communication about hereditary cancer“. Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20973.
Der volle Inhalt der QuelleWright, C. M. „The prognostic significance of microsatellite instability in sporadic stage C colorectal cancer“. Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28955.
Der volle Inhalt der Quelle陳潔盈 und Kit-ying Loucia Chan. „Expression analysis of Candidate cancer genes in non-small cell lung cancer“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011163.
Der volle Inhalt der QuelleHussien, M. „Folate status, genetic damage and breast cancer“. Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269044.
Der volle Inhalt der QuelleAshton, Kevin John, und K. Ashton@griffith edu au. „Genetic Aberrations in Non-Melanoma Skin Cancer“. Griffith University. School of Health Science, 2002. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030818.122305.
Der volle Inhalt der QuelleGentile, Massimiliano. „Genetic alterations in early onset breast cancer /“. Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med686s.pdf.
Der volle Inhalt der QuelleValdman, Alexander. „Molecular genetic markers of prostate cancer development /“. Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-618-9/.
Der volle Inhalt der QuelleWedrén, Sara. „Genetic susceptibility to breast and endometrial cancer /“. Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-053-2/.
Der volle Inhalt der QuelleFransén, Karin. „Molecular genetic aspects of colorectal cancer development /“. Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med878s.pdf.
Der volle Inhalt der QuelleSalahshor, Sima. „Different genetic pathways involved in colorectal cancer /“. Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4690-6/.
Der volle Inhalt der QuelleLake, Sarah Louise. „Genetic analysis of LPHH1 in lung cancer“. Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404506.
Der volle Inhalt der QuelleSteggles, Naomi. „Psychological aspects of genetic testing for cancer“. Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271020.
Der volle Inhalt der QuelleFord, Deborah. „Genetic epidemiology of breast and ovarian cancer“. Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367527.
Der volle Inhalt der QuelleBabalghith, Ahmad Omar. „Genetic events involved in bladder cancer progression“. Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445140.
Der volle Inhalt der QuelleVessey, Carina Jayne. „Genetic predisposition to genomic instability in cancer“. Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262690.
Der volle Inhalt der QuelleSmith, Joel Anthony. „Molecular genetic investigation of medullary thyroid cancer“. Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6314/.
Der volle Inhalt der QuelleBolton, Kelly. „The genetic epidemiology of ovarian cancer survival“. Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610071.
Der volle Inhalt der QuelleMackay, James. „Molecular genetic studies in human breast cancer“. Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19076.
Der volle Inhalt der QuelleJohns, Neil. „Phenotypes and genetic markers of cancer cachexia“. Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23392.
Der volle Inhalt der QuelleLam, Man-Yee Josephine. „Genetic Control of Susceptibility to Testicular Cancer“. Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1112676217.
Der volle Inhalt der QuelleAllan, Lindsey A. „The molecular genetic events of ovarian cancer“. Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068634.
Der volle Inhalt der QuelleKim, Eejung. „Functional characterization of genetic alterations in cancer“. Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493591.
Der volle Inhalt der QuelleMedical Sciences
Adams, David James. „The Genetic and Therapeutic Landscape of Cancer“. Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29490.
Der volle Inhalt der QuelleAshton, Kevin John. „Genetic Aberrations in Non-Melanoma Skin Cancer“. Thesis, Griffith University, 2002. http://hdl.handle.net/10072/367012.
Der volle Inhalt der QuelleThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Health Sciences
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