Auswahl der wissenschaftlichen Literatur zum Thema „Fluorinated ski wax“

In the summer of 2019, eleven of the best-selling fluorinated ski wax products were purchased from one of Norway's largest sports stores and soon after analysed for a suite of 26 per- and polyfluoroalkyl substances (PFAS).

The chemical industry is a particularly sensitive sector that very often works with toxic, harmful and dangerous substances. This paper offers insight into the corporate socially responsible (CSR) behaviour of a specific segment of the chemical industry—the production of fluorinated ski waxes. Perfluorinated compounds, which excel in water and fat stability and repellency, are nowadays considered as harmful to human health and nature. During 2020, the basic compound, perfluorooctanoic acid (PFOA), will be banned, and finding its replacement will be a difficult task. So far, there are no alternatives in terms of environmentally friendly compounds that can maintain the desired properties of extreme ski glide. Based on a questionnaire distributed to twenty wax producers worldwide, we have concluded that, although the attitudes of companies towards CSR certification was rather negative (87.5%), and companies had not developed or documented any CSR policy/strategy with specific goals, they found CSR activities/instruments beneficial and important. The survey highlighted the fact that companies were aware that their products are dangerous for the environment, and that environmental issues are important for all of the responders, despite them being mostly without certified systems. The size of a company had no significant effect on their attitude. Micro and small producers were involved in raising awareness of environmental policies and responsibilities to the same extent (maybe even more) as medium or large companies. We also found varying behaviours between companies involved in environmental programs and those who were not. The companies involved felt a strong attitude towards all three pillars of CSR, which are the environment, as well as social and economic aspects. Those companies not involved had a strong attitude towards their customers, but not towards their employees, suppliers or the wider community. They also had stronger feelings about the quality of their products and economic profit, but without a strong approach to the related environmental issues. The Norwegian approach and the commitment of the company Swix to CSR are two positive examples leading to a fluorine-free future.

Solid-state electrolytes (SSEs) are receiving great interest because their high mechanical strength and transference number could potentially suppress Li dendrites and their high electrochemical stability allows the use of high-voltage cathodes, which enhances the energy density and safety of batteries. However, the much lower critical current density and easier Li dendrite propagation in SSEs than in nonaqueous liquid electrolytes hindered their possible applications. Herein, we successfully suppressed Li dendrite growth in SSEs by in situ forming an LiF-rich solid electrolyte interphase (SEI) between the SSEs and the Li metal. The LiF-rich SEI successfully suppresses the penetration of Li dendrites into SSEs, while the low electronic conductivity and the intrinsic electrochemical stability of LiF block side reactions between the SSEs and Li. The LiF-rich SEI enhances the room temperature critical current density of Li3PS4to a record-high value of >2 mA cm−2. Moreover, the Li plating/stripping Coulombic efficiency was escalated from 88% of pristine Li3PS4to more than 98% for LiF-coated Li3PS4. In situ formation of electronic insulating LiF-rich SEI provides an effective way to prevent Li dendrites in the SSEs, constituting a substantial leap toward the practical applications of next-generation high-energy solid-state Li metal batteries.

Above its critical point, carbon dioxide forms a super-critical fluid, which promises to be an environmentally responsible replacement for the organic solvents traditionally used in polymerizations. Many lipophilic polymers such as polystyrene (PS) are insoluble in CO2, though polymerizations may be accomplished via the use of PS-fluoropolymer stabilizers, which act as emulsifying agents. Small-angle neutron and X-ray scattering have been used to show that these molecules form micelles with a CO2-phobic PS core and a CO2-philic fluoropolymer corona. When the PS block was fixed in length and the fluorinated corona block was varied, the number of block copolymer molecules per micelle (six to seven) remained constant. Thus, the coronal block molecular weight exerts negligible influence on the aggregation number, in accordance with the theoretical predictions of Halperin, Tirrell & Lodge [Adv. Polym. Sci. (1992), 100, 31–46]. These observations are relevant to understanding the mechanisms of micellization and solubilization in supercritical fluids.

Labeling of macrophages with perfluorocarbon (PFC)-based compounds allows the visualization of inflammatory processes by 19F-magnetic resonance imaging (19F-MRI), due to the absence of endogenous background. Even if PFC-labeling of monocytes/macrophages has been largely investigated and used, information is lacking about the impact of these agents over the polarization towards one of their cell subsets and on the best way to image them. In the present work, a PFC-based nanoemulsion was developed to monitor the course of inflammation in a model of spinal cord injury (SCI), a pathology in which the understanding of immunological events is of utmost importance to select the optimal therapeutic strategies. The effects of PFC over macrophage polarization were studied in vitro, on cultured macrophages, and in vivo, in a mouse SCI model, by testing and comparing various cell tracking protocols, including single and multiple administrations, the use of MRI or Point Resolved Spectroscopy (PRESS), and application of pre-saturation of Kupffer cells. The blood half-life of nanoemulsion was also investigated by 19F Magnetic Resonance Spectroscopy (MRS). In vitro and in vivo results indicate the occurrence of a switch towards the M2 (anti-inflammatory) phenotype, suggesting a possible theranostic function of these nanoparticles. The comparative work presented here allows the reader to select the most appropriate protocol according to the research objectives (quantitative data acquisition, visual monitoring of macrophage recruitment, theranostic purpose, rapid MRI acquisition, etc.). Finally, the method developed here to determine the blood half-life of the PFC nanoemulsion can be extended to other fluorinated compounds.

Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. Fast reversible inhibition of AChE by TFK is of competitive type with Ki = 5.15 nM. However, steady state of inhibition is reached slowly. Kinetic analysis showed that TFK is a slow-binding inhibitor (SBI) of type B with Ki* = 0.53 nM. Reversible binding of TFK provides a long residence time, τ = 20 min, on AChE. After binding, TFK acylates the active serine, forming an hemiketal. Then, disruption of hemiketal (deacylation) is slow. AChE recovers full activity in approximately 40 min. Molecular docking and MD simulations depicted the different steps. It was shown that TFK binds first to the peripheral anionic site. Then, subsequent slow induced-fit step enlarged the gorge, allowing tight adjustment into the catalytic active site. Modeling of interactions between TFK and AChE active site by QM/MM showed that the “isomerization” step of enzyme-inhibitor complex leads to a complex similar to substrate tetrahedral intermediate, a so-called “transition state analog”, followed by a labile covalent intermediate. SBIs of AChE show prolonged pharmacological efficacy. Thus, this fluoroalkylketone intended for neuroimaging, could be of interest in palliative therapy of Alzheimer’s disease and protection of central AChE against organophosphorus compounds.

Per- and polyfluorinated substances (PFAS) are used in the production of ski wax to reduce the friction between the snow and the ski. In this occupational study of ski wax technicians’ exposure to PFAS and particulate aerosol we have collected whole blood (wb) (n =94), air (n =84) and aerosol (n =159) samples at World Cup events from 2007-2011. We have analysed the blood, air and aerosol with respect to 13 perfluorocarboxylic acids (PFCAs), 4 perfluorosulfonic acids (PFSAs), 3 fluorotelomer alcohols (FTOHs), 3 fluorotelomer acids (FTCAs) and 3 unsaturated fluorotelomer acids (FTUCAs). Further, we assessed the exposure to 3 particulate aerosol fractions (inhalable, respirable and total aerosol) in air. In comparison to a general population, several of the PFCA blood levels are elevated in the technicians’, primarily  erfluorooctanoate (PFOA) and perfluorononate (PFNA) with concentrations up to 628 and 163 ng/mL wb, respectively. Further,  we detected FTUCAs and FTCAs in the blood, suggesting biotransformation of FTOHs to PFCAs. The metabolites 5:3 and 7:3 FTCA were detected in all blood samples at levels up to 6.1 and 3.9 ng/mL wb. Levels of perfluorohexadecanoic acid PFHxDA) and perfluorooctadecanoic acid (PFOcDA) were detected in the technician’s blood at mean concentration up to 4.22 ng/mL wb and 4.25 ng/mL wb. The FTOH levels in air of the wax cabin during work ranged up to 997 000 ng/m3 (average=114 000 ng/m3 ) and PFOA up to 4 890 ng/m3 (average= 526 ng/m3 . FTOHs were not detected in aerosols but PFOA showed average levels of 12 000 ng/m3 (range=1 230- 46 900 ng/m3 ). The occupational exposure limit (OEL) of 2 mg/m3 was exceeded in 37% of the personal measurements with aerosol  concentrations up to 15 mg/m3 . Keywords : Perfluorinated, polyfluorinated, FIS, occupational exposure, ski wax,  iotransformation, metabolism, fluorotelomer alcohol, fluorotelomer acid, aerosol, dust, UPLC/MS-MS, GC/MS-MS

Poly- och perfluorerade ämnen, även kallad PFAS, har både globalt och i Sverige upptäckts i höga halter i mark samt i yt-och grundvatten de senaste åren. Kemikalierna är svårnedbrytbara och studier visar på att de bland annat är reproduktionsstörande hos djur. Källorna till utsläpp av PFAS är många, men något som uppmärksammats den senaste tiden är fluorvallor som används inom längdskidåkning. I den här studien undersöks hur användningen av skidvalla innehållande PFAS påverkar ett område samt hur dessa ämnen sprids. För att undersöka detta har tidigare mätningar utförda i anslutning till längdskidspår använts, för att se hur spridningen skett vid dem samt vilka koncentrationer som kan påträffas.  Mätningarna var utförda vid skidspår i Oslo, Trondheim, vid Vasaloppet samt vid en tävling i Maine, USA. För att visualisera var i Sverige påverkade områden skulle kunna finnas gjordes dessutom en karta där orter togs ut på två olika sätt. Skidvalla bidrar till att orsaka högre lokala koncentrationer av PFAS, och kan få en stor påverkan i de områden där mycket skidåkning pågår. Samtidigt är det svårt att dra tydliga slutsatser då det finns fåtal studier och många diffusa källor som kan bidra till spridningen av PFAS.
Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used for their water, grease, and dirt repellent properties. Today these substances are widespread due to their ability to spread through both air and water. PFAS are long-term persistent and have hazardous environmental impact. Among others, affecting the reproduction of animals and has been shown to accumulate in the food chain. One product containing PFAS that has recently gained attention is fluorinated ski wax, due to the ban imposed on fluorinated ski wax by the International Ski Federation (FIS) from the season 2021/2022.  To investigate how the use of ski wax containing PFAS spreads and affects the environment at areas with cross-country skiing, results from previous studies have been analyzed. The previous studies were located at cross-country ski areas in Oslo and Trondheim in Norway, Maine in the USA and at the location of the Swedish competition Vasaloppet. A map has also been made to visualize where in Sweden there might be areas who have been contaminated with per- and polyfluoroalkyl substances by the use of ski wax. To find the locations for these areas two different methods have been used.  The results of the previous studies shows that the use of fluorinated ski waxes gives higher local concentrations of PFAS at the locations of cross-country ski areas that are frequently used. However, it is still difficult to draw clear conclusions about how big the spread of PFAS contamination is, since the substances can be found in many different products and are easily spread. In the future there is a need for more studies and investigation to reach clearer conclusions. In addition, there is a need for more tests around different ski areas to see the impact that competitions have, but also how everyday skiing affects the spread of PFAS.

High performance single-phase Si microchannel coolers have been designed and characterized in single chip modules in a laboratory environment using either water at 22°C or a fluorinated fluid at temperatures between 20 and −40°C as the coolant. Compared to our previous work, key performance improvements were achieved through reduced channel pitch (from 75 to 60 microns), thinned channel bases (from 425 to 200 microns of Si), improved thermal interface materials, and a thinned thermal test chip (from 725 to 400 microns of Si). With multiple heat exchanger zones and 60 micron pitch microchannels with a water flow rate of 1.25 lpm, an average unit thermal resistance of 15.9 C-mm2/W between the chip surface and the inlet cooling water was demonstrated for a Si microchannel cooler attached to a chip with Ag epoxy. Replacing the Ag epoxy layer with an In solder layer reduced the unit thermal resistance to 12.0 C-mm2/W. Using a fluorinated fluid with an inlet temperature of −30°C and 60 micron pitch microchannels with an Ag epoxy thermal interface layer, the average unit thermal resistance was 25.6 C-mm2/W. This fell to 22.6 C-mm2/W with an In thermal interface layer. Cooling >500 W/cm2 was demonstrated with water. Using a fluorinated fluid with an inlet temperature of −30°C, a chip with a power density of 270 W/cm2 was cooled to an average chip surface temperature of 35°C. Results using both water and a fluorinated fluid are presented for a range of Si microchannel designs with a channel pitch from 60 to 100 microns.