Thematische Bibliographien / Fascicle mechanics

Inhaltsverzeichnis

  1. Zeitschriftenartikel
  2. Dissertationen
  3. Bücher
  4. Buchteile
  5. Konferenzberichte

Auswahl der wissenschaftlichen Literatur zum Thema „Fascicle mechanics“

Autor: Grafiati
Veröffentlicht am 21. Januar 2025

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Zeitschriftenartikel zum Thema "Fascicle mechanics"

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Wakeling, James M., Meghan Jackman, and Ana I. Namburete. "The Effect of External Compression on the Mechanics of Muscle Contraction." Journal of Applied Biomechanics 29, no. 3 (2013): 360–64. http://dx.doi.org/10.1123/jab.29.3.360.

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The velocity at which a muscle fascicle will shorten, and hence the force that it can develop, depends on its gearing within the muscle belly. Muscle fascicle length depends on both its pennation and the thickness of the muscle. It was expected that external compression would reduce the muscle thickness and pennation and thus cause a reduction to the gearing of the fascicles relative to the muscle belly. Structural properties of the medial gastrocnemius muscle were visualized using B-mode ultrasound in six subjects. Measurements were taken during cyclical isotonic contractions at three differe
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Brennan, Scott F., Andrew G. Cresswell, Dominic J. Farris, and Glen A. Lichtwark. "The effect of muscle-tendon unit vs. fascicle analyses on vastus lateralis force-generating capacity during constant power output cycling with variable cadence." Journal of Applied Physiology 124, no. 4 (2018): 993–1002. http://dx.doi.org/10.1152/japplphysiol.00356.2017.

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The maximum force-generating capacity of a muscle is dependent on the lengths and velocities of its contractile apparatus. Muscle-tendon unit (MTU) length changes can be estimated from joint kinematics; however, contractile element length changes are more difficult to predict during dynamic contractions. The aim of this study was to compare vastus lateralis (VL) MTU and fascicle level force-length and force-velocity relationships, and dynamic muscle function while cycling at a constant submaximal power output (2.5 W/kg) with different cadences. We hypothesized that manipulating cadence at a co
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Farris, Dominic James, Benjamin D. Robertson, and Gregory S. Sawicki. "Elastic ankle exoskeletons reduce soleus muscle force but not work in human hopping." Journal of Applied Physiology 115, no. 5 (2013): 579–85. http://dx.doi.org/10.1152/japplphysiol.00253.2013.

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Inspired by elastic energy storage and return in tendons of human leg muscle-tendon units (MTU), exoskeletons often place a spring in parallel with an MTU to assist the MTU. However, this might perturb the normally efficient MTU mechanics and actually increase active muscle mechanical work. This study tested the effects of elastic parallel assistance on MTU mechanics. Participants hopped with and without spring-loaded ankle exoskeletons that assisted plantar flexion. An inverse dynamics analysis, combined with in vivo ultrasound imaging of soleus fascicles and surface electromyography, was use
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De Brito Fontana, Heiliane, and Walter Herzog. "Fascicle shortening upon activation in voluntary human muscle contractions." Brazilian Journal of Motor Behavior 17, no. 5 (2023): 238–45. http://dx.doi.org/10.20338/bjmb.v17i5.380.

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BACKGROUND: The dependence of fascicle length on complex interactions with joint angle and force challenges the interpretation of in vivo joint mechanics, muscle mechanical properties, contractile behavior, and muscle function. AIM: The purpose of this study was to determine the complex interaction between muscle activation, joint angle, and fascicle length for isometric contractions of the human vastus lateralis muscle (VL). METHOD: Knee extensor torques, joint angles, EMG activation, and fascicle lengths were determined in nine healthy subjects during maximal and submaximal isometric contrac
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Lai, Adrian, Anthony G. Schache, Nicholas A. T. Brown, and Marcus G. Pandy. "Human ankle plantar flexor muscle–tendon mechanics and energetics during maximum acceleration sprinting." Journal of The Royal Society Interface 13, no. 121 (2016): 20160391. http://dx.doi.org/10.1098/rsif.2016.0391.

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Tendon elastic strain energy is the dominant contributor to muscle–tendon work during steady-state running. Does this behaviour also occur for sprint accelerations? We used experimental data and computational modelling to quantify muscle fascicle work and tendon elastic strain energy for the human ankle plantar flexors (specifically soleus and medial gastrocnemius) for multiple foot contacts of a maximal sprint as well as for running at a steady-state speed. Positive work done by the soleus and medial gastrocnemius muscle fascicles decreased incrementally throughout the maximal sprint and both
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Roberts, T. J., M. S. Chen, and C. R. Taylor. "Energetics of bipedal running. II. Limb design and running mechanics." Journal of Experimental Biology 201, no. 19 (1998): 2753–62. http://dx.doi.org/10.1242/jeb.201.19.2753.

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Compared with quadrupeds, bipedal runners of the same weight have longer legs, take longer steps and can presumably use slower, more economical muscle fibers. One might predict that bipedal running is less expensive, but it is not. We hypothesized that bipeds recruit a larger volume of muscle to support their weight, eliminating the potential economy of longer legs and slower steps. To test our hypothesis, we calculated the relative volume of muscle needed to support body weight over a stride in small dogs (Canis familiaris) and wild turkeys (Meleagris gallopavo) of the same weight. First, we
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Wakeling, James M., Katrin Uehli, and Antra I. Rozitis. "Muscle fibre recruitment can respond to the mechanics of the muscle contraction." Journal of The Royal Society Interface 3, no. 9 (2006): 533–44. http://dx.doi.org/10.1098/rsif.2006.0113.

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This study investigates the motor unit recruitment patterns between and within muscles of the triceps surae during cycling on a stationary ergometer at a range of pedal speeds and resistances. Muscle activity was measured from the soleus (SOL), medial gastrocnemius (MG) and lateral gastrocnemius (LG) using surface electromyography (EMG) and quantified using wavelet and principal component analysis. Muscle fascicle strain rates were quantified using ultrasonography, and the muscle–tendon unit lengths were calculated from the segmental kinematics. The EMG intensities showed that the body uses th
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Shin, David D., John A. Hodgson, V. Reggie Edgerton, and Shantanu Sinha. "In vivo intramuscular fascicle-aponeuroses dynamics of the human medial gastrocnemius during plantarflexion and dorsiflexion of the foot." Journal of Applied Physiology 107, no. 4 (2009): 1276–84. http://dx.doi.org/10.1152/japplphysiol.91598.2008.

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Velocity-encoded phase-contrast magnetic resonance (MR) imaging techniques and a computer-controlled MR-compatible foot pedal device were used to investigate the medial gastrocnemius muscle and aponeurosis deformations during passive and active eccentric movements of the plantarflexors. Intrafascicular strain, measured as the ratio of strain in the fascicle segment at its insertion to strain at its origin, was nonuniform along the proximodistal axis of the muscle ( P < 0.01), progressively increasing from the proximal to distal direction. The high intrafascicular strain regions appeared to
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Valadão, P., S. Kurokawa, T. Finni, and J. Avela. "Effects of muscle action type on corticospinal excitability and triceps surae muscle-tendon mechanics." Journal of Neurophysiology 119, no. 2 (2018): 563–72. http://dx.doi.org/10.1152/jn.00079.2017.

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This study investigated whether the specific motor control strategy reported for eccentric muscle actions is dependent on muscle mechanical behavior. Motor evoked potentials, Hoffman reflex (H-reflex), fascicle length, pennation angle, and fascicle velocity of soleus muscle were compared between isometric and two eccentric conditions. Ten volunteers performed maximal plantarflexion trials in isometric, slow eccentric (25°/s), and fast eccentric (100°/s) conditions, each in a different randomized testing session. H-reflex normalized by the preceding M wave (H/M) was depressed in both eccentric
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Dabrowska, Sylwia, Krzysztof Grabowski, and Andrzej Mlyniec. "Rehydration of the Tendon Fascicle Bundles Using Simulated Body Fluid Ensures Stable Mechanical Properties of the Samples." Materials 15, no. 9 (2022): 3033. http://dx.doi.org/10.3390/ma15093033.

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In this work, we investigate the influence of dehydration and subsequent rehydration of tendon fascicle bundles on their structural and mechanical properties by using distilled water, 0.9% NaCl, 10% NaCl, SBF, and double concentrated SBF (SBFx2). The properties of tendon fascicle bundles were investigated by means of uniaxial tests with relaxation periods and hysteresis for samples with various interfascicular matrix content, dissected from the anterior and posterior areas of bovine tendon. Uniaxial tests with relaxation periods and analysis of sample geometry and weight showed that dehydratio
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Dissertationen zum Thema "Fascicle mechanics"

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Tamiwa, Masami. "Dynamic Mechanical Characterisation of Rat-tail Tendon Fascicles." Thesis, Queen Mary, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498180.

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Kim, Hyeon Yu Ph D. Massachusetts Institute of Technology. "Effect of mechanical stretching on the maturation of 3-D fascicle-like muscle tissue." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/93828.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 52-55).<br>Skeletal muscle is well known for a rapid adaptation to mechanical environmental changes. Understanding the effects of the mechanical stimulation such as stretching to muscle tissues is important for understanding the nature of muscle development and muscle diseases. While there are many reports studying the effects of stretching on 2-D cultures in vitro, few research groups have investigated their eff
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Neal, Devin Michael. "Elongated fascicle-inspired 3D tissues consisting of high-density, aligned, optogenetically excitable muscle tissue using sacrificial outer molding." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92166.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 80-89).<br>The majority of muscles, nerves, and tendons are composed of fiber-like fascicle morphology. Each fascicle has a) elongated cells highly aligned with the length of the construct, b) a high volumetric cell density, and c) a high length-to-width ratio with a diameter small enough to facilitate perfusion. Fiber-like fascicles are important building blocks for forming those tissues of various sizes and c
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Robinson, M. W. "Mechanisms of benzimidazole resistance in the liver fluke, Fasciola hepatica." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273381.

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Savage, J. E. "Studies on the mechanism of resistance to triclabendazole in the liver fluke Fasciola hepatica." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546421.

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Devine, C. "Elucidation of the mechanism of resistance to triclabendazole in the liver fluke, Fasciola hepatica." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546044.

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Hollville, Enzo. "Impact du type de surface sur la réponse à l’exercice : du muscle au mouvement Interactions between fascicles and tendinous tissues in gastrocnemius medialis and vastus lateralis during drop landing How surface properties affect fascicle-tendon interactions during drop landing? Muscle-tendon interactions in jumping: influence of surface properties." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB018.

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Les propriétés des surfaces sportives peuvent impacter directement la performance et le risque de blessure en modulant la part d’énergie transmise à l'athlète lors de l'impact du pied sur la surface. Les pelouses naturelle et synthétique sont couramment utilisées sur les terrains de football et de rugby. Depuis quelques années, une nouvelle génération de pelouse dite naturelle renforcée a fait son apparition dans les clubs professionnels mais son influence sur la biomécanique du geste sportif est encore mal connue. Cette thèse vise à évaluer l'influence de trois types de surfaces (gazon nature
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Ribeiro, Ana Paula. "Avaliação estática do complexo tornozelo-pé e padrões dinâmicos da distribuição da pressão plantar de corredores com e sem fasciite plantar." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5163/tde-27052010-164407/.

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A fasciite plantar é considerada a terceira doença mais comum em corredores. Apesar dessa alta prevalência, sua patogênese ainda é inconclusiva. Na literatura desalinhamento do retropé, mudanças na conformação do arco longitudinal plantar e um aumento da carga mecânica sobre os pés, têm sido embasados como fatores de risco para o desenvolvimento da fasciite plantar. No entanto, há uma escassez de estudos que investigaram estes fatores, durante a corrida. A maior parte da literatura investigou, especificamente, a marcha e os resultados apresentam-se controversos e ainda não claros, principalmen
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Gotti, Carlo. "Development and mechanical characterization of a biostable Nylon6.6 electrospun nanofibrous multiscale device for tendon and ligament replacement and simulation." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15708/.

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This thesis aims to investigate electrospun structures by means their production process and morpho-mechanical characterization. Considering the results obtained, the electrospun devices developed, will be useful for tendon and ligament tissue applications.
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Mulero, Stephen. "Développement d’outils d’écologie moléculaire pour un suivi intégratif des maladies transmises par les mollusques d’eau douce dans un contexte d’émergences et de changements globaux A Multiplex Rapid Diagnostic PCR (RD-PCR) approach for xenomonitoring of human and animal schistosomiases in a One Health context Genetic diversity and relationships of the liver fluke Fasciola hepatica (Trematoda) with native and introduced definitive and intermediate hosts Simultaneous genotyping of gastropods and their trematode parasites using Amplicon Sequencing Pre-zygotic isolation mechanisms between Schistosoma haematobium and Schistosoma bovis parasites: from mating interactions to differential gene expression." Thesis, Perpignan, 2020. http://www.theses.fr/2020PERP0023.

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Les changements globaux, qu’ils soient d’origine climatique ou anthropique ont diverses conséquences en santé humaine et animale, mais aussi sur les écosystèmes mondiaux. L’une des plus importantes est la modification des aires de répartitions géographiques des espèces et de celle des pathogènes qui leurs sont associés. C’est dans ce contexte que nous assistons ces dernières années à une recrudescence des cas d’émergences et de réémergences de maladies infectieuses dans le monde. Alors que les efforts de recherche menés dans ce domaine se focalisent principalement sur les maladies virales, les
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Bücher zum Thema "Fascicle mechanics"

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Stecco, Luigi. Fascial manipulation for muscuskeletal pain. Piccin Nuova Libraria S.p.A., 2004.

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Misra, V. Peter, and Santiago Catania. EMG-guided botulinum toxin therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688395.003.0026.

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This chapter explains the mechanism by which botulinum neurotoxin (BoNT) causes its neuromuscular paralytic effects, and reviews the developments that led these effects to be harnessed therapeutically. It specifically focuses upon the conditions of dystonia and spasticity. Within the spectrum of these diseases, it discusses those situations where BoNT injections are the treatment of choice. The very accurate targeting of BoNT into specific muscles in many situations is both desirable and crucial in some situations BoNT’s therapeutic neuroparalytic effect may need to be restricted to a single m
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Buchteile zum Thema "Fascicle mechanics"

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Chun, Keyoung Jin, and D. L. Butler. "Spatial Variation in Material Properties in Fascicle-Bone Units from Human Patellar Tendon." In Experimental Mechanics in Nano and Biotechnology. Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/0-87849-415-4.797.

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Bonaldi, Lorenza, Alice Berardo, and Chiara Giulia Fontanella. "The Mechanical Behavior of the Fascial System." In Fascia, Function, and Medical Applications, 2nd ed. CRC Press, 2024. http://dx.doi.org/10.1201/9781032675886-12.

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Robinson, Mark W., John P. Dalton, Sandra M. O'Neill, and Sheila M. Donnelly. "Mechanisms of Immune Modulation by Fasciola hepatica: Importance for Vaccine Development and for Novel Immunotherapeutics." In Parasitic Helminths. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527652969.ch27.

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Sarnat, Harvey B., and Laura Flores-Sarnat. "Cerebral Cortical Dysplasia or Dysgenesis." In Jasper's Basic Mechanisms of the Epilepsies, 5th ed., edited by Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Annamaria Vezzani, and Antonio V. Delgado-Escueta. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197549469.003.0003.

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Abstract Embryonic and fetal ontogenesis of the central nervous system is realized by genetically programmed developmental processes with precise timing of onset. Both anatomical development and timing are altered in brain malformations. Keratan sulfate (KS) proteoglycan is a key axonal pathfinding guide and insulator of tracts and fascicles within the central nervous system and an essential determinant of the equilibrium of excitation and inhibition at the level of the individual neuron during development. KS is selective by repelling glutamatergic axons and facilitating GABAergic axons at sites of synapse formation. Its demonstration by immunocytochemistry provides another perspective for understanding epileptogenesis at the cellular level in brain resections for epilepsy and at autopsy, including fetal tissues. Examples of malformations in which epileptogenesis is influenced by KS are polymicrogyria, schizencephaly, focal cortical dysplasias, holoprosencephaly, and Down syndrome.
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Wise, Steven P. "Human hemispheres." In Cortical Evolution in Primates. Oxford University PressOxford, 2023. http://dx.doi.org/10.1093/oso/9780192868398.003.0014.

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Abstract A few new areas probably emerged in the human cortex, but the major development was a dramatic expansion of the typically layered areas (more commonly known as homotypical association cortex). Mainly because of their enlargement, the cortex expanded into the modern human size range, mostly in the past two million years. A transcortical network that includes connections between temporal and frontal cortex via the arcuate fascicle enlarged and reorganized. In addition, the hippocampus decreased in relative size during most of anthropoid evolution but increased during human evolution, which reflects new inputs and functions. The genetic mechanisms of cortical expansion include gene duplications that extend neural stem-cell proliferation and keep neurons in an immature state, thus increasing the number of dendritic spines and synapses. A within-gene deletion in the chimpanzee–human common ancestor promoted synaptogenesis in the prefrontal cortex.
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Viswanathan, Ashwin. "Pelvic/Visceral Cancer Pain." In Pain Neurosurgery. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190887674.003.0014.

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The management of medically refractory cancer pain is a complex, multi-disciplinary effort. When optimal medical management has failed, neuroablative and neuromodulatory efforts can be used. While neuromodulation is an attractive option due its minimally invasive nature, neuroablation offers the advantage of high efficacy and the lack of maintenance or upkeep requirements. Punctate midline myelotomy is an ablative procedure targeting the ascending visceral pain pathway in the dorsal columns. The procedure can be performed through an open approach creating a mechanical lesion, or percutaneously via either a mechanical lesion or radiofrequency ablation. Careful attention to the spinal cord midline during lesion creation and attention to surgical technique, including an excellent fascial closure, can minimize potential complications.
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Kawai, Tomonori. "Shear Wave Elastography for Chronic Musculoskeletal Problem." In Elastography - Applications in Clinical Medicine [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102024.

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Shear wave elastography is a new noninvasive tool for the analysis of the biomechanical properties of the muscles in healthy and pathological conditions. Shear wave elastography is currently considered as a promising real-time visualization tool for quantifying explicitly the mechanical properties of soft tissues in sports medicine including muscle strain injury (MSI). This chapter shows utilizing diagnostic tools of magnetic resonance imaging, B mode ultrasound (US), and shear wave elastography in both acute and chronic phases. Also, the proposal for this chapter is to indicate the possibility of utilizing shear wave elastography for musculoskeletal injury, not only properties of the muscle but also fascial tissues. It introduces the relationship between previous muscle strain injury and local soft tissue stiffness, and we assessed the mechanical properties of soft tissues from a clinical perspective.
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Wong, Agnes. "Nuclear and Infranuclear Ocular Motor Disorders." In Eye Movement Disorders. Oxford University Press, 2008. http://dx.doi.org/10.1093/oso/9780195324266.003.0021.

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Binocular diplopia is usually caused by strabismus, whereas monocular diplopia is usually caused by ocular diseases. Incomitant diplopia is usually caused by an acquired strabismus resulting from abnormal innervation or mechanical restriction. The oculomotor (third) nerve: ■ Innervates the medial rectus, superior rectus, inferior rectus, inferior oblique, and levator palpebrae muscles ■ Carries parasympathetic fibers to the iris sphincter and the ciliary body. ■ Common causes of third nerve palsy: Adults: aneurysms, vascular disease (including ischemia, diabetes, hypertension, and inflammatory arteritis), trauma, migraine Children: birth trauma, accidental trauma, neonatal hypoxia, migraine The third nerve originates from the oculomotor nucleus complex, which lies at the ventral border of the periaqueductal gray matter in the midbrain. The nerve fascicle passes ventrally through the medial longitudinal fasciculus, the tegmentum, the red nucleus, and the substantia nigra, and finally emerges from the cerebral peduncle to form the oculomotor nerve trunk, which lies between the superior cerebellar and posterior cerebral arteries. The nerve then passes through the subarachnoid space, running beneath the free edge of the tentorium. It continues lateral to the posterior communicating artery and below the temporal lobe uncus, where it runs over the petroclinoid ligament. It pierces the dura mater at the top of the clivus to enter the cavernous sinus. Within the cavernous sinus, the nerve runs along the lateral wall of the sinus together with the trochlear nerve and the ophthalmic (V1) and maxillary (V2) divisions of the trigeminal nerve. As it leaves the cavernous sinus, it divides into the superior and inferior divisions, which pass through the superior orbital fissure, and enters the orbit within the annulus of Zinn. Within the orbit, the smaller superior division runs lateral to the optic nerve and ophthalmic artery and supplies the superior rectus and levator palpebrae muscles. The larger inferior division supplies the medial rectus, inferior rectus, and inferior oblique muscles, as well as the iris sphincter and ciliary body.
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"Mechanisms of Immune Modulation by Fasciola Hepatica: The Impact of Innate Immune Cells on the Developing Adaptive Immune Response." In Immune Response to Parasitic Infections, edited by Sandra M. O'Neill and Sheila Donnelly. BENTHAM SCIENCE PUBLISHERS, 2014. http://dx.doi.org/10.2174/9781608059850114020006.

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Konferenzberichte zum Thema "Fascicle mechanics"

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Robinson, Paul S., Tony W. Lin, Paul R. Reynolds, Kathleen A. Derwin, Renato V. Iozzo, and Louis J. Soslowsky. "Potential Roles for Collagen and Decorin in Strain Rate Sensitive Tendon Fascicle Mechanical Properties." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23064.

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Abstract Little is known about the contributions of specific extracellular matrix components of tendon to the tissue’s mechanical properties. Type I collagen, given its abundance and association into long fibrils, is thought to dominate the elastic properties of tendon. Proteoglycans (PGs) are believed to provide elasticity through their potential role in transferring stress between discontinuous fibrils, as well as viscoelasticity via their interaction with water. Previous studies suggest relationships between collagen or PGs and tissue mechanics [1,2]. However, no study to date has isolated
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Thorpe, Chavaunne T., Helen L. Birch, Peter D. Clegg, and Hazel R. C. Screen. "Effect of Fatigue Loading on Tendon Fascicle Extension Mechanisms." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14009.

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Tendon injury is common, probably occurring due to accumulation of microdamage within the tendon matrix as a result of repetitive loading rather than as a sudden onset condition 1. The human Achilles tendon is highly susceptible to injury; this tendon functions as an energy store and experiences high stresses and strains during normal use 2. The equine superficial digital flexor (SDFT) is also an energy storing tendon and is highly injury prone, therefore it is often used as a model to study structure function relationships within this type of tendon 3. Our previous work has characterized the
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Valenti, Fabio. "The Fascial System." In Socratic Lectures 8. University of Lubljana Press, 2023. http://dx.doi.org/10.55295/psl.2023.i13.

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The word Fascia has long been used by gross anatomists to embrace a spectrum of undifferentiated mesenchymal tissues that wrap organs and tissues of the body, or form a packing material between them. The inherent implication of this traditional view is that fasciae are inconsequential residues that are less important than the tissues with which they are associated. The errors of this assumption are being exposed and undoubtedly fascia is becoming more and more of considerable importance to many professionals working in health-related disciplines. Encouragingly, there has been a strong resurgen
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Poudel, Biswas, and Istemi B. Ozsoy. "Finite Element Analysis of the Critical Buckling Load in Hollow Microneedles With Lateral Support." In ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-94699.

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Abstract Hollow microneedles provide minimum invasion to the skin and painless drug and vaccine delivery. However, there is a risk of fracture due to insufficient mechanical strength. The strength of microneedles might be increased by mimicking the bite of a mosquito. A mosquito has a proboscis that consists of a long needle (fascicle) surrounded by a protective sheath (labium). This sheath (labium) folds back as the fascicle pierces the skin, which provides lateral support to the fascicle. The lateral support increases the force that can be applied at the tip of the needle without buckling. I
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Haslach, Henry W., Jonathan Chung, and Aviva Molotsky. "Fracture Mechanisms in Bovine Aorta." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19366.

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Rupture of vascular tissue in the circulatory system under non-impact loading is involved in potentially life threatening events such as Marfan’s syndrome or rupture of small renal veins during shock wave lithotripsy. The rupture mechanisms are not well-understood. The complexity of the artery wall precludes the use of rupture theories invented for metals or for fibered composites with a homogeneous matrix. Artery tissue is composed of ground material, smooth muscle cells, elastin and collagen. The collagen fibers, which are generally circumferentially oriented, are the load carrying material
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Han, Woojin M., Nandan L. Nerurkar, Lachlan J. Smith, Nathan T. Jacobs, Robert L. Mauck, and Dawn M. Elliott. "Multi-Scale Structural and Tensile Mechanical Response of Annulus Fibrosus to Osmotic Loading." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80471.

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The annulus fibrosus (AF) is a multi-lamellar fibrocartilagenous ring in the intervertebral disc. The variation of biochemical composition from the outer to the inner AF is largely responsible for the heterogeneous mechanical properties. In vitro tissue-level studies require mechanical testing in aqueous buffers to avoid tissue dehydration. The varying glycosaminoglycan (GAG) contents from outer to inner AF suggest that the response to high and low PBS osmolarity may also be different with radial position. Previous studies in tendon and ligament have been conflicting: soaking tendon fascicles
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Saeidi, Nima, and Jeffrey W. Ruberti. "Smart Molecules: Organization and Morphology of the Self-Assembled Collagen Fibrils Formed From a Solution of Densly Packed Collagen Monomers." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193025.

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Load-bearing tissues owe their mechanical properties to the presence of highly-organized arrays of collagen fibrils. Aligned lamellae in cornea and aligned fascicles in tendon are the best examples of collagen fibrillar organization at the macroscopic level. The process by which collagen is organized in the extracellular matrix (ECM) is still unclear. But it is generally thought to be facilitated locally via “fibripositors” or cell surface “crypts”. According to this theory, fibroblasts create bounded “compartments” in the ECM through which they deposit organized groups of fibrils (in the form
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Marie, Hazel, Diana L. Fagan, and Jeremy Heffner. "Biomechanical Evaluation of Autologous Mesenchymal Stem Cell Transplantation to Improve Fascial Repair." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12466.

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Hernia repair continues to be one of the major problems faced by surgeons. Up to 10% of laparotomies are complicated by post-operative incisional hernia, carrying with it a myriad of complications ranging from cosmetic disfigurement to life-threatening strangulation of the bowel [1]. A large percentage of these incisional hernias will recur following surgical repair leading to a more vicious cycle of hernia, followed by repair, followed by hernia. It is therefore imperative to create a more optimum wound-healing environment. The intent of this study was to investigate a novel approach for sign
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Reese, Shawn P., and Jeffrey A. Weiss. "Micromechanical Model of a Collagen Based Tendon Surrogate: Development and Validation." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80949.

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In tendons and ligaments, collagen is organized hierarchically into nanoscale fibrils, microscale fibers and mesoscale fascicles. Force transfer across scales is complex and poorly understood, and macroscale strains are not representative of the microscale strains [1]. Since innervation, the vasculature, damage mechanisms and mechanotransduction occur at the microscale, understanding such multiscale interactions is of high importance. In this study, a physical model was used in combination with a computational model to isolate and study the mechanisms of force transfer between scales. The obje
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Cheng, Xingguo, Nicholas Wasserman, and Ozan Akkus. "Improving the Anisotropy of Collagen by Electric Field Increases Its Toughness by Two-Fold." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176705.

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Collagen is the major structural protein in the connective tissues such as skin, bone, ligaments, and tendons. The specific hierarchical organization of collagen molecules determines the unique properties of each specific tissue. For example, in tendon, the parallel alignment of collagen molecules, fibrils, fibril bundles, fascicles and tendon units gives tendon good mechanical properties. Thus, in vitro engineering of collagen molecules hold great promise as a tissue regeneration material. However, there is a need for mechanically superior collagenous structures, which currently cannot be pro
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