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Auswahl der wissenschaftlichen Literatur zum Thema „Extrachromosomal circular DNA“
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Zeitschriftenartikel zum Thema "Extrachromosomal circular DNA"
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Gonzalez, Rocio Chamorro, Thomas Conrad, Robin Xu, Madalina Giurgiu, Maja Cwikla, Katharina Kasack, Lotte Brückner et al. „Abstract 1693: Dissecting intercellular extrachromosomal circular DNA heterogeneity in single cancer cells with scEC&T-seq“. Cancer Research 82, Nr. 12_Supplement (15.06.2022): 1693. http://dx.doi.org/10.1158/1538-7445.am2022-1693.
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Abstract Extrachromosomal DNA circularization is a common event in cancer cells and frequently serves as a vehicle for cancer oncogene amplification. Random segregation of oncogene-containing extrachromosomal circular DNA promotes rapid intercellular heterogeneity, conferring tumors the ability to rapidly evolve and escape therapy. Smaller, copy-number neutral extrachromosomal circular DNAs are also abundantly identified in both healthy and malignant tissues, but their function in cancer is still unknown. Understanding how extrachromosomal circular DNAs contribute to intercellular heterogeneity in cancer cells remains crucial, however methods for an unbiased characterization of extrachromosomal circular DNAs in single cells are lacking. We introduce scEC&T-seq (single cell extrachromosomal circular DNA and transcriptomic sequencing), a method for parallel detection of extrachromosomal circular DNAs and full-length mRNA in single cells. We demonstrate the ability of our method to isolate and detect extrachromosomal circular DNAs genome-wide from all range of sizes in single cells. We observed that whereas large oncogene-containing circular DNAs are clonally present in most cancer cells, only a very small fraction of small circular DNAs are recurrently identified in single cells, indicating yet unknown prerequisites for maintenance and propagation. Our method was able to capture and recapitulate the structural complexity of oncogene-containing extrachromosomal circular DNAs in single cells, and the matching transcriptomic data allowed us to identify fusion transcripts resulting from the rearranged extrachromosomal structures. In addition, we observed that whereas the main structure of extrachromosomal circular DNAs is mostly stable in single cells, intercellular differences in extrachromosomal circular DNAs’ content can drive differences in oncogene transcription levels in single cells. We envision that by integrating extrachromosomal circular DNA and mRNA sequencing, our method will not only be useful to investigate the impact of intercellular heterogeneity in extrachromosomal circular DNA in tumor evolution, but also to interrogate its function in other biological and pathological processes. Citation Format: Rocio Chamorro Gonzalez, Thomas Conrad, Robin Xu, Madalina Giurgiu, Maja Cwikla, Katharina Kasack, Lotte Brückner, Eric van Leen, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Yi Bei, Karin Schmelz, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen. Dissecting intercellular extrachromosomal circular DNA heterogeneity in single cancer cells with scEC&T-seq [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1693.
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Wang, Keyi, Hui Tian, Lequn Wang, Lin Wang, Yacong Tan, Ziting Zhang, Kai Sun et al. „Deciphering extrachromosomal circular DNA in Arabidopsis“. Computational and Structural Biotechnology Journal 19 (2021): 1176–83. http://dx.doi.org/10.1016/j.csbj.2021.01.043.
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Shimizu, Noriaki. „Gene Amplification and the Extrachromosomal Circular DNA“. Genes 12, Nr. 10 (28.09.2021): 1533. http://dx.doi.org/10.3390/genes12101533.
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Oncogene amplification is closely linked to the pathogenesis of a broad spectrum of human malignant tumors. The amplified genes localize either to the extrachromosomal circular DNA, which has been referred to as cytogenetically visible double minutes (DMs), or submicroscopic episome, or to the chromosomal homogeneously staining region (HSR). The extrachromosomal circle from a chromosome arm can initiate gene amplification, resulting in the formation of DMs or HSR, if it had a sequence element required for replication initiation (the replication initiation region/matrix attachment region; the IR/MAR), under a genetic background that permits gene amplification. In this article, the nature, intracellular behavior, generation, and contribution to cancer genome plasticity of such extrachromosomal circles are summarized and discussed by reviewing recent articles on these topics. Such studies are critical in the understanding and treating human cancer, and also for the production of recombinant proteins such as biopharmaceuticals by increasing the recombinant genes in the cells.
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Cohen, Sarit, Sophie Menut und Marcel Méchali. „Regulated Formation of Extrachromosomal Circular DNA Molecules during Development in Xenopus laevis“. Molecular and Cellular Biology 19, Nr. 10 (01.10.1999): 6682–89. http://dx.doi.org/10.1128/mcb.19.10.6682.
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ABSTRACT Extrachromosomal circular DNA molecules of chromosomal origin have been detected in many organisms and are thought to reflect genomic plasticity in eukaryotic cells. Here we report a developmentally regulated formation of extrachromosomal circular DNA that occurs de novo in preblastula Xenopus embryos. This specific DNA population is not detected in the male or female germ cells and is dramatically reduced in later developmental stages and in adult tissues. The activity responsible for the de novo production of extrachromosomal circles is maternally inherited, is stored in the unfertilized egg, and requires genomic DNA as a template. The formation of circular molecules does not require genomic DNA replication but both processes can occur simultaneously in the early development. The production of extrachromosomal circular DNA does not proceed at random since multimers of the tandemly repeated sequence satellite 1 were over-represented in the circle population, while other sequences (such as ribosomal DNA and JCC31 repeated sequence) were not detected. This phenomenon reveals an unexpected plasticity of the embryonic genome which is restricted to the early developmental stage.
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Møller, Henrik D., Lance Parsons, Tue S. Jørgensen, David Botstein und Birgitte Regenberg. „Extrachromosomal circular DNA is common in yeast“. Proceedings of the National Academy of Sciences 112, Nr. 24 (02.06.2015): E3114—E3122. http://dx.doi.org/10.1073/pnas.1508825112.
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Examples of extrachromosomal circular DNAs (eccDNAs) are found in many organisms, but their impact on genetic variation at the genome scale has not been investigated. We mapped 1,756 eccDNAs in the Saccharomyces cerevisiae genome using Circle-Seq, a highly sensitive eccDNA purification method. Yeast eccDNAs ranged from an arbitrary lower limit of 1 kb up to 38 kb and covered 23% of the genome, representing thousands of genes. EccDNA arose both from genomic regions with repetitive sequences ≥15 bases long and from regions with short or no repetitive sequences. Some eccDNAs were identified in several yeast populations. These eccDNAs contained ribosomal genes, transposon remnants, and tandemly repeated genes (HXT6/7, ENA1/2/5, and CUP1-1/-2) that were generally enriched on eccDNAs. EccDNAs seemed to be replicated and 80% contained consensus sequences for autonomous replication origins that could explain their maintenance. Our data suggest that eccDNAs are common in S. cerevisiae, where they might contribute substantially to genetic variation and evolution.
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Sun, Teng, Kun Wang, Cuiyun Liu, Yin Wang, Jianxun Wang und Peifeng Li. „Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei“. Cells 8, Nr. 2 (01.02.2019): 111. http://dx.doi.org/10.3390/cells8020111.
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Extrachromosomal DNA exists in two forms: Covalently closed circular and linear. While diverse types of circular extrachromosomal DNA have been identified with validated in vivo functions, little is known about linear extrachromosomal DNA. In this study, we identified small, single-stranded linear extrachromosomal DNAs (SSLmicroDNAs) in the nuclei of mouse hearts, mouse brains, HEK293, and HeLa cells. We used a pull-down system based on the single-stranded DNA binding protein RecAf. We found that SSLmicroDNAs aligned predominantly to intergenic and intragenic regions of the genome, owned a variety of single nucleotide polymorphism sites, and strongly associated with H3K27Ac marks. The regions were tens to hundreds of nucleotides long, periodically separated by AT, TT, or AA dinucleotides. It has been demonstrated that SSLmicroDNAs in the nuclei of normal cells target microRNAs, which regulate biological processes. In summary, our present work identified a new form of extrachromosomal DNAs, which function inside nuclei and interact with microRNAs. This finding provides a possible research field into the function of extrachromosomal DNA.
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Yerlici, V. Talya, Michael W. Lu, Carla R. Hoge, Richard V. Miller, Rafik Neme, Jaspreet S. Khurana, John R. Bracht und Laura F. Landweber. „Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA“. Nucleic Acids Research 47, Nr. 18 (28.08.2019): 9741–60. http://dx.doi.org/10.1093/nar/gkz725.
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Abstract Extrachromosomal circular DNA (eccDNA) is both a driver of eukaryotic genome instability and a product of programmed genome rearrangements, but its extent had not been surveyed in Oxytricha, a ciliate with elaborate DNA elimination and translocation during development. Here, we captured rearrangement-specific circular DNA molecules across the genome to gain insight into its processes of programmed genome rearrangement. We recovered thousands of circularly excised Tc1/mariner-type transposable elements and high confidence non-repetitive germline-limited loci. We verified their bona fide circular topology using circular DNA deep-sequencing, 2D gel electrophoresis and inverse polymerase chain reaction. In contrast to the precise circular excision of transposable elements, we report widespread heterogeneity in the circular excision of non-repetitive germline-limited loci. We also demonstrate that circular DNAs are transcribed in Oxytricha, producing rearrangement-specific long non-coding RNAs. The programmed formation of thousands of eccDNA molecules makes Oxytricha a model system for studying nucleic acid topology. It also suggests involvement of eccDNA in programmed genome rearrangement.
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Clark, C. G., und G. A. Cross. „rRNA genes of Naegleria gruberi are carried exclusively on a 14-kilobase-pair plasmid“. Molecular and Cellular Biology 7, Nr. 9 (September 1987): 3027–31. http://dx.doi.org/10.1128/mcb.7.9.3027-3031.1987.
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An extrachromosomal DNA was discovered in Naegleria gruberi. The 3,000 to 5,000 copies per cell of this 14-kilobase-pair circular plasmid carry all the 18S, 28S, and 5.8S rRNA genes. The presence of the ribosomal DNA of an organism exclusively on a circular extrachromosomal element is without precedent, and Naegleria is only the third eucaryotic genus in which a nuclear plasmid DNA has been found.
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Clark, C. G., und G. A. Cross. „rRNA genes of Naegleria gruberi are carried exclusively on a 14-kilobase-pair plasmid.“ Molecular and Cellular Biology 7, Nr. 9 (September 1987): 3027–31. http://dx.doi.org/10.1128/mcb.7.9.3027.
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An extrachromosomal DNA was discovered in Naegleria gruberi. The 3,000 to 5,000 copies per cell of this 14-kilobase-pair circular plasmid carry all the 18S, 28S, and 5.8S rRNA genes. The presence of the ribosomal DNA of an organism exclusively on a circular extrachromosomal element is without precedent, and Naegleria is only the third eucaryotic genus in which a nuclear plasmid DNA has been found.
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Ain, Quratul, Christian Schmeer, Diane Wengerodt, Otto W. Witte und Alexandra Kretz. „Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration“. International Journal of Molecular Sciences 21, Nr. 7 (02.04.2020): 2477. http://dx.doi.org/10.3390/ijms21072477.
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Still unresolved is the question of how a lifetime accumulation of somatic gene copy number alterations impact organ functionality and aging and age-related pathologies. Such an issue appears particularly relevant in the broadly post-mitotic central nervous system (CNS), where non-replicative neurons are restricted in DNA-repair choices and are prone to accumulate DNA damage, as they remain unreplaced over a lifetime. Both DNA injuries and consecutive DNA-repair strategies are processes that can evoke extrachromosomal circular DNA species, apparently from either part of the genome. Due to their capacity to amplify gene copies and related transcripts, the individual cellular load of extrachromosomal circular DNAs will contribute to a dynamic pool of additional coding and regulatory chromatin elements. Analogous to tumor tissues, where the mosaicism of circular DNAs plays a well-characterized role in oncogene plasticity and drug resistance, we suggest involvement of the “circulome” also in the CNS. Accordingly, we summarize current knowledge on the molecular biogenesis, homeostasis and gene regulatory impacts of circular extrachromosomal DNA and propose, in light of recent discoveries, a critical role in CNS aging and neurodegeneration. Future studies will elucidate the influence of individual extrachromosomal DNA species according to their sequence complexity and regional distribution or cell-type-specific abundance.
Dissertationen zum Thema "Extrachromosomal circular DNA"
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Rodriguez, Fos Elias. „Study of complex chromosomal rearrangements in cancer. The role of extrachromosomal circular DNA as a genome remodeler in neuroblastoma“. Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/672713.
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This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological data and the detection of variants to gain more knowledge about the genetic and molecular implications of human diseases, such as cancer, has allowed me to learn and conduct my research.
Focusing on the analysis of structural variation in cancer, I have been able to apply different methodologies for sequencing data, retrieving, filtering, and determining the mutational profile foreach ofthe studied samples.Moreover,I have characterized new patterns of genomic rearrangements related to transposase-derived genes and extrachromosomal circular DNA elements in cancer. Therefore, this thesis is centered in the study of the genomic variation and mechanisms associated with oncogenic processes together with the analysis of elements of the human genome that are not generally included in comprehensive cancer studies, such as circular DNA elements.
In summary, starting with the introduction, I give an overview of the methodological aspects of the study of cancer through the impact of sequencing technologies, the biological and molecular causes and consequences of this disease, focusing on structural variation, and the description of the circular DNA genomic component and its known implications in cancer. Finally, I introduce neuroblastoma, an example of how structural variants and circular DNA drive tumorigenesis.
Next, I present the results of this thesis in three blocks, all of which have in common the study of structural variation in cancer. Two of the blocks correspond to the PGBD5 and neuroblastoma publications, and one corresponds to the continuation of the PGBD5 analysis in ICGC-Pan-Cancer data.
As an overview of the trajectory of this thesis, I started with my involvement in a project focused on analyzing the role of PGBD5 —a transposase-derived gene—
as an oncogenic mutator with an associated mechanism for site-specific DNA rearrangements. In this study, we describe how the expression of this gene promotes cell transformation and the generation of recurrent rearrangements, presenting a conserved motif in cell lines and childhood tumors. As a logical continuation of this publication and thanks to the access of our group to ICGC-PCAWG data, we expanded the study of these characteristic PGBD5-motif-related rearrangements to different patients and tumor types.
The following part of this thesis is focused on the analysis, description, and classification of the genomic somatic rearrangements in neuroblastoma. With the aim of better grouping the patients with different clinical outcomes, we searched for differential patterns of structural variants across the samples. From this analysis, we were able to describe a new phenomenon that connects circular DNA with different integration sites around the genome through complex rearrangement clusters providing evidence on how circular DNA can act as a driver of genomic remodeling in neuroblastoma.
To finalize, I present the general discussion of the results and questions addressed in this work to, then, end up disclosing the final conclusions of this thesis.
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Zhang, Panpan. „Étude du paysage des éléments transposables sous forme d'ADN circulaire extrachromosomique et dans l'assemblage des génomes de plantes à l'aide du séquençage en lectures longues“. Thesis, Université de Montpellier (2022-….), 2022. http://www.theses.fr/2022UMONG016.
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Les éléments transposables (TEs) sont des séquences d'ADN répétitives avec la capacité intrinsèque de se déplacer et de s’amplifier dans les génomes. La transposition active des TEs est liée à la formation d'ADN circulaire extrachromosomique (ADNecc). Cependant, le paysage complet de ce compartiment d’ADNecc ainsi que ces interactions avec le génome n’étaient pas bien définies. De plus, il n’existait au début de ma thèse aucun outil bioinformatique permettant d'identifier les ADNecc à partir de données de séquençage en lectures longues. Pour répondre à ces questions au cours de mon doctorat, nous avons tout d'abord développé un outil, appelé ecc_finder, pour automatiser la détection d'eccDNA à partir de séquences en lectures longues et optimisé la détection à partir de séquences de lecture courte pour caractériser la mobilité des TE. En appliquant ecc_finder aux données eccDNA-seq d'Arabidopsis, de l'homme et du blé (avec des tailles de génome allant de 120 Mb à 17 Gb), nous avons documenté l'applicabilité étendue d'ecc_finder ainsi que l’optimisation du temps de calcul, de la sensibilité et de la précision.Dans le deuxième projet, nous avons développé un outil de méta-assemblage appelé SASAR pour réconcilier les résultats de différents assemblages de génomes à partir de données de séquençage en lectures longues. Pour différentes espèces de plantes, SASAR a obtenu des assemblages de génome de haute qualité en un temps efficace et a résolu les variations structurales causées par les TE.Dans le dernier projet, nous avons utilisé le génome assemblé par SASAR et l'ADNecc détecté par ecc_finder pour caractériser les interactions entre les ADNecc et le génome. Dans les mutants épigénétiques hypométhylés d’Arabidopsis, nous avons mis en évidence le rôle de l'épigénome dans la protection de la stabilité du génome non seulement contre la mobilité des TE mais aussi envers les réarrangements génomiques et le chimérisme des gènes. Globalement, nos découvertes sur l'ADNecc, l'assemblage du génome et leurs interactions, ainsi que le développement d'outils, offrent de nouvelles perspectives pour comprendre le rôle des TE dans l'évolution adaptative des plantes à un changement rapide de l’environnementTransposable elements (TEs) are repetitive DNA sequences with the intrinsic ability to move and amplify in genomes. Active transposition of TEs is linked to the formation of extrachromosomal circular DNA (eccDNA). However, the complete landscape of this eccDNA compartment and its interactions with the genome were not well defined. In addition, at the beginning of my thesis, there were no bioinformatics tools available to identify eccDNAs from long-read sequencing data.To address these questions during my PhD, we first developed a tool, called ecc_finder, to automate eccDNA detection from long-read sequencing and optimized detection from short-read sequences to characterize TE mobility. By applying ecc_finder to Arabidopsis, human and wheat eccDNA-seq data (with genome sizes ranging from 120 Mb to 17 Gb), we documented the broad applicability of ecc_finder as well as optimization of computational time, sensitivity and accuracy.In the second project, we developed a meta-assembly tool called SASAR to reconcile the results of different genome assemblies from long-read sequencing data. For different plant species, SASAR obtained high quality genome assemblies in an efficient time and resolved structural variations caused by TEs.In the last project, we used SASAR-assembled genome and ecc_finder-detected eccDNA to characterize eccDNA-genome interactions. In Arabidopsis hypomethylated epigenetic mutants, we highlighted the role of the epigenome in protecting genome stability not only from TE mobility but also from genomic rearrangements and gene chimerism. Overall, our findings on eccDNA, genome assembly and their interactions, as well as the development of tools, offer new insights into the role of TEs in the adaptive evolution of plants to rapid environmental change
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Pont, Geneviève. „Adn circulaires extrachromosomiques dans les embryons de drosophila melanogaster : caracterisation d'une classe moleculaire homologue aux genes histones“. Clermont-Ferrand 2, 1987. http://www.theses.fr/1987CLF21068.
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Burkert, Christian Martin. „Cis-regulation and genetic control of gene expression in neuroblastoma“. Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23008.
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Genregulation beeinflusst Phänotypen im Kontext von Gesundheit und Krankheit. In Krebszellen regulieren genetische und epigenetische Faktoren die Genexpression in cis. Das Neuroblastom ist eine Krebserkrankung, die häufig im Kindesalter auftritt. Es ist gekennzeichnet durch eine geringe Anzahl exonischer Mutationen und durch häufige Veränderungen der somatischen Kopienzahl, einschließlich Genamplifikationen auf extrachromosomaler zirkulärer DNA. Bisher ist wenig darüber bekannt, wie lokale genetische und epigenetische Faktoren Gene im Neuroblastom regulieren. In dieser Arbeit kombiniere ich die allelspezifische Analyse ganzer Genome (WGS), Transkriptome und zirkulärer DNA von Neuroblastom-Patienten, um genetische und cis-regulatorische Effekte zu charakterisieren. Ich zeige, dass somatische Dosis-Effekte der Kopienzahl andere lokale genetische Effekte dominieren und wichtige Signalwege regulieren. Genamplifikationen zeigen starke Dosis-Effekte und befinden sich häufig auf großen extrachromosomalen zirkulären DNAs. Die vorgestellte Analyse zeigt, dass der Verlust von 11q zu einer Hochregulation von Histonvarianten H3.3 und H2A in Tumoren mit alternativer Verlängerung der Telomere (ALT) führt, und dass erhöhte somatische Kopienzahl die Expression der TERT Gens verstärken können. Weitere Erkenntnisse sind, dass 17p-Ungleichgewichte und die damit verbundene Herunterregulierung neuronaler Gene sowie die Hochregulierung des genomisch geprägten Gens RTL1 durch Kopienzahl-unabhängige allelische Dosis-Effekte mit einer ungünstigen Prognose verbunden sind. Die cis-QTL-Analyse bestätigt eine zuvor beschriebene Regulation des LMO1 Gens durch einen Enhancer-Polymorphismus und charakterisiert das regulatorische Potenzial weiterer GWAS-Risiko-Loci. Die Arbeit unterstreicht die Bedeutung von Dosis-Effekten im Neuroblastom und liefert eine detaillierte Übersicht regulatorischer Varianten, die in dieser Krankheit aktiv sind.Gene regulation controls phenotypes in health and disease. In cancer, the interplay between germline variation, genetic aberrations and epigenetic factors modulate gene expression in cis. The childhood cancer neuroblastoma originates from progenitor cells of the sympathetic nervous system. It is characterized by a sparsity of recurrent exonic mutations but frequent somatic copy-number alterations, including gene amplifications on extrachromosomal circular DNA. So far, little is known on how local genetic and epigenetic factors regulate genes in neuroblastoma to establish disease phenotypes. I here combine allele-specific analysis of whole genomes, transcriptomes and circular DNA from neuroblastoma patients to characterize genetic and cis-regulatory effects, and prioritize germline regulatory variants by cis-QTLs mapping and chromatin profiles. The results show that somatic copy-number dosage dominates local genetic effects and regulates pathways involved in telomere maintenance, genomic stability and neuronal processes. Gene amplifications show strong dosage effects and are frequently located on large but not small extrachromosomal circular DNAs. My analysis implicates 11q loss in the upregulation of histone variants H3.3 and H2A in tumors with alternative lengthening of telomeres and cooperative effects of somatic rearrangements and somatic copy-number gains in the upregulation of TERT. Both 17p copy-number imbalances and associated downregulation of neuronal genes as well as upregulation of the imprinted gene RTL1 by copy-number-independent allelic dosage effects is associated with an unfavorable prognosis. cis-QTL analysis confirms the previously reported regulation of the LMO1 gene by a super-enhancer risk polymorphism and characterizes the regulatory potential of additional GWAS risk loci. My work highlights the importance of dosage effects in neuroblastoma and provides a detailed map of regulatory variation active in this disease.
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LI, SHENG-YI, und 李盛義. „Extrachromosomal circular DNA in drug-Resistant Leishmania:emergence, changes and possible function“. Thesis, 1990. http://ndltd.ncl.edu.tw/handle/50424003175896766945.
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Lumpkin, Charles K., John R. McGill, Karl T. Riabowol, E. J. Moerman, Robert J. Shmookler Reis und Samuel Goldstein. „Extrachromosomal Circular DNA and Aging Cells“. In Advances in Experimental Medicine and Biology, 479–93. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-7853-2_24.
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Graupner, S., und W. Wackernagel. „Identification and Characterization of Extrachromosomal Circular DNA Released from a Genetically Modified Chromosome of Hansenula polymorpha“. In Transgenic Organisms and Biosafety, 171–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61460-6_18.
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Yousuf, Parvaiz. „Circular DNA: How Circular DNA Assists Cancer Roll with Therapeutic Punches“. In Gene Expression [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102687.
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DNA within cells is either present in the form of long strands as in eukaryotes or circular shapes in Yeast plasmids, mitochondrial DNA, and double minutes in tumor cells. Apart from them, ribosomal or telomeric DNA has been found to produce specialized forms of extrachromosomal circular DNA (eccDNA). eccDNA was discovered in both normal and cancer cells in recent times, indicating a much more significant role. The eccDNA has been found to promote tumor proliferation, survival, and aggressiveness in almost half of all cancers by increasing oncogene copy numbers. This chapter will discuss the biogenesis and function of eccDNA and how it promotes tumor adaption under changing microtumour environmental conditions, as in the case of drugs.
Konferenzberichte zum Thema "Extrachromosomal circular DNA"
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Chapman, Owen S., Shanqing Wang, Jens Luebeck, Alexandra Garancher, Jon D. Larson, Joshua Lange, John Crawford et al. „Abstract 95: The landscape of extrachromosomal circular DNA in medulloblastoma subgroups“. In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-95.
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Zhu, Jing, Meijun Du, Peng Zhang und Liang Wang. „Abstract 4244: Detection and characterization of extrachromosomal circular DNA in human plasma“. In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4244.
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