Dissertationen zum Thema „Enzymes Synthesis“
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Ekici, Özlem Doğan. „Design, synthesis, and evaluation of novel irreversible inhibitors for caspases“. Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04062004-164633/unrestricted/ekici%5Fozlem%5Fd%5F200312%5Fphd.pdf.
Ekici, Ozlem Dogan. „Design, synthesis, and evaluation of novel irreversible inhibitors for caspases“. Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5333.
Naylor, Neil J. „Biotransformations involving hydrolytic enzymes“. Thesis, University of Warwick, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263607.
Silveira, Alvito J. „Synthesis of 6-guanidinobenzoxazinones as potential inhibitors of trypsin-like enzymes“. Thesis, Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/26914.
Snider, Catherine E. „Synthesis and biochemical evaluation of irreversible inhibitors of aromatase /“. The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266362338344.
Carnell, Andrew John. „Cycloalkanone monooxygenase enzymes in organic synthesis“. Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293971.
Blum, Janna Karen. „Broadening the enyzme-catalyzed synthesis of semi-synthetic antibiotics“. Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39528.
Admans, Gary David. „Asymmetric transformations catalysed by lipase enzymes“. Thesis, University of Exeter, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240288.
Chambers, Martina Natasha. „Synthesis of cellulosic glycolipids using engineered enzymes“. Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46032.
Ahmed, Naveed. „The synthesis of inhibitors of proteolytic enzymes“. Thesis, University of Huddersfield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416765.
Davis, Benjamin G. „Synthesis of inhibitors of sugar processing enzymes“. Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711593.
Dotse, Anthony Kwabla. „Design, synthesis and evaluation of novel inhibitors of cysteine proteases, metalloproteases and the proteasome, a unique high molecular weight proteolytic enzyme“. Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/29979.
Parekh, Parag A. „Bioprocess development for asymmetric reductions by Saccharomyces cerevisiae enzymes“. [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0014371.
Qiu, Jian. „Synthesis of inhibitors of terpene and shikimate enzymes“. Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627500.
Guilly, Selena. „Synthesis of novel acceptor substrates for glycosyltransferase enzymes“. Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/16997.
Mazda, Xerxes Cyrus. „Synthesis of substrate analogues for terpene cyclase enzymes“. Thesis, University of Cambridge, 1992. https://www.repository.cam.ac.uk/handle/1810/272667.
Holt, Karen Elizabeth. „Asymmetric synthesis of aza-sugars using aldolase enzymes“. Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272658.
Vázquez-Figueroa, Eduardo. „Development of a novel dehydrogenase and a stable cofactor regeneration system“. Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31685.
Committee Chair: Bommarius, Andreas S.; Committee Member: Doyle, Donald F.; Committee Member: Koros, William J.; Committee Member: Moore, Jeffre C.; Committee Member: Prausnitz, Mark R. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Heng, Sabrina. „The Design, Synthesis and Characterization of Enzyme Inhibitors“. Thesis, Boston College, 2009. http://hdl.handle.net/2345/755.
Thesis advisor: Mary F. Roberts
In this work, a series of inhibitors of two enzymes, aspartate transcarbamoylase (ATCase) and fructose 1,6-bisphosphatase (FBPase) were designed, synthesized and characterized. ATCase catalyzes the committed step in pyrimidine nucleotide biosynthesis, the reaction between carbamoyl phosphate (CP) and L-aspartate to form N-carbamoyl-L-aspartate (CA) and inorganic phosphate. This step is exceptionally important because once CA is formed, it is committed to the biosynthesis of pyrimidines, a necessary component for nucleic acid biosynthesis. The pyrimidine biosynthetic pathway plays an important regulatory role in cell proliferation since there is evidence that intracellular nucleotide pools control DNA replication and consequently cell division. Thus, the enzymes of pyrimidine biosynthesis, both in the de novo and salvage pathways, are targets for anti-proliferation drugs. Fructose 1,6-bisphosphatase (FBPase) is responsible for the hydrolysis of fructose 1,6-bisphosphate (F16BP) to fructose 6-phosphate (F6P). As the key enzyme at the control point in the gluconeogenesis pathway, FBPase presents an opportunity for the development of novel inhibitors against type-2 diabetes aimed at lowering the hepatic glucose production in type-2 diabetes. With ATCase, the design, synthesis and characterization of (1) T-state inhibitors composed of two phosphonacetamide groups linked together by a variety of functionalities and (2) analogs of N-phosphonacetyl-L-aspartate, a potent inhibitor of ATCase, were accomplished. With FBPase, a library of allosteric inhibitors, of which, the lead compound was initially identified through a virtual high-throughput screening system, was developed. In addition, this work also aimed to find the in vivo target for achyrofuran, a natural product derived from Achyrocline satureoides which has been shown to significantly lower blood glucose levels in db/db mouse for type-2 diabetes. The last project presents evidences that FBPase is the likely in vivo target for achyrofuran. This was accomplished through the use of computational docking experiments and by the synthesis of a new class of inhibitors based on the achyrofuran scaffold
Thesis (PhD) — Boston College, 2009
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
Hinchliffe, Paul Stuart. „The synthesis of #beta#-sultam inhibitors of proteolytic enzymes“. Thesis, University of Huddersfield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368328.
Bingham, Matilda Jane. „Insights into the design and synthesis of artificial enzymes“. Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395525.
Lemoult, Stephanie Claudette. „Biocatalysis in organic synthesis using microorganisms and immobilised enzymes“. Thesis, University of Exeter, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260622.
Newgas, Sophie Alice. „Biocatalysis using plant and metagenomic enzymes for organic synthesis“. Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10052003/.
Scaffidi, Adrian. „Synthetic endeavours in carbohydrates“. University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0114.
Chada, Sravanthi. „A new synthetic approach for preparation of efavirenz“. Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/15512.
Oldfield, C. „The behaviour of enzymes in water-in-oil microemulsion systems“. Thesis, University of Kent, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380705.
Vousden, William Alexander. „Mutational analysis of the ACV synthetase gene of Aspergillus nidulans“. Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366097.
Sutherland, Andrew. „The enantioselective synthesis of amino acids for the investigation of protein structure“. Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388029.
Clough, Sarah. „Routes to the synthesis of oxygen containing heterocycles“. Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301998.
Feng, Jun. „A kinetic investigation of recombinant xenopus laevis amidating enzymes“. Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/30084.
Sampson, Peter B. „Synthesis of potential inhibitors targeting enzymes involved in methionine biochemistry“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0018/NQ53511.pdf.
Johnson, Dean Vincent. „The synthesis of optically active chiral building blocks using enzymes“. Thesis, University of Exeter, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317396.
Watt, Alan. „Synthesis of novel benzotriazole substrates suitable for screening hydrolytic enzymes“. Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/11529.
Lin, Jay. „Enzymes in thymidylate synthesis in Ureaplasma parvum as medical targets /“. Uppsala : Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/11487069.pdf.
Ndi, Cornelius Ndi. „Synthesis of Chemical Models of Hydrolase Enzymes for Intramolecular Catalysis“. Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1356.
Chen, Allen Kuan-Liang Biotechnology & Biomolecular Sciences Faculty of Science UNSW. „Enhanced biocatalyst production for (R)-phenylacetylcarbinol synthesis“. Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2006. http://handle.unsw.edu.au/1959.4/32825.
Rickaby, Kirstie. „Investigation of the chemo-enzymatic synthesis of cyclic peptides“. Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238613.
Simkovsky, Nadja Melitta. „Synthesis of some potential IKK inhibitors based around a pyrimidine scaffold“. Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367619.
Maddrell, Samuel James. „The application of organonitrile compounds to asymmetric synthesis“. Thesis, University of Exeter, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294473.
Aitken, D. J. „Approaches to selective synthesis using modified enzyme systems“. Thesis, University of Strathclyde, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381516.
Khan, Ahmed M. „Cyclic enzymatic solid phase synthesis of DNA oligonucleotides on an epoxide-activated resin [electronic resource] /“. unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05082008-163131/.
Title from file title page. Markus W. Germann, committee chair; W. David Wilson, Kathryn B. Grant, committee members. Electronic text (51 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed July 14, 2008. Includes bibliographical references (p. 50-51).
Wharry, Thomas Scott. „The synthesis of novel phosphonate and phosphinate inhibitors of proteinase enzymes“. Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263577.
Wilks, Helen M. „Design and synthesis of new enzymes on the lactate dehydrogenase framework“. Thesis, University of Bristol, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282796.
Agyei-Owusu, Kwasi. „Synthesis and evaluation of novel inhibitors of thiamin diphosphate-dependent enzymes“. Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608816.
Jareño, Cerulla Júlia. „Synthesis of Mn/Fe heterodimers as model complexes for heterobimetallic enzymes“. Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-225957.
Mutthamsetty, Vinay. „Design and Synthesis of Amino Acid-based Inhibitors Against Key Enzymes“. University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1513014525316672.
Storey, Benjamin 1973. „AQX : a novel gene in plant ubiquinone biosynthesis“. Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80882.
Morgan, C. R. „Properties and synthesis of the ribulose-1,5-biphosphate carboxylase large subunit binding protein“. Thesis, University of Warwick, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373050.
Mitra, Adinpunya. „4-hydroxycinnamoyl-CoA hydratase/lyase from Pseudomonas fluorescens AN103 : characterisation and effects of expression in transformed root cultures of Datura stramonium“. Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301994.
Parikh, Bhargiv. „Design, Synthesis and Characterization of D-glucosamine Low Molecular Weight Gelators“. ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1110.