Auswahl der wissenschaftlichen Literatur zum Thema „Effet de position télomérique“
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Zeitschriftenartikel zum Thema "Effet de position télomérique"
Decottignies, Anabelle. „L’effet de position télomérique“. médecine/sciences 30, Nr. 2 (Februar 2014): 173–78. http://dx.doi.org/10.1051/medsci/20143002015.
Der volle Inhalt der QuellePorchet, F., N. Bruder, G. Boulard, DP Archer und P. Ravussin. „Effet de la position sur la pression intracrânienne“. Annales Françaises d'Anesthésie et de Réanimation 17, Nr. 2 (Januar 1998): 149–56. http://dx.doi.org/10.1016/s0750-7658(98)80065-8.
Der volle Inhalt der QuelleBourzgui, Farid, Sanaa Alami, Mourad Sebbar, Taoufik Derkaoui, Mouna Hamza, Zineb Serhier und Mohamed Bennani Othmani. „Effet du traitement orthodontique sur la position des lèvres“. International Orthodontics 11, Nr. 3 (September 2013): 303–13. http://dx.doi.org/10.1016/j.ortho.2013.05.002.
Der volle Inhalt der QuelleGoodluck, Helen, und Lawrence Solan. „Un effet du principe C chez l’enfant francophone“. Canadian Journal of Linguistics/Revue canadienne de linguistique 45, Nr. 1-2 (Juni 2000): 49–62. http://dx.doi.org/10.1017/s0008413100017606.
Der volle Inhalt der QuelleDe Sève, Michel, und Marlen Carter. „Les inégalités salariales entre les travailleurs des deux sexes : effet de qualification ou effet de statut?“ Articles 21, Nr. 3 (12.04.2005): 253–82. http://dx.doi.org/10.7202/055892ar.
Der volle Inhalt der QuelleBourguignon, Abigail, Kevin Diter, Holly Hargis, Wilfried Lignier, Hélène Oehmichen, Julie Pagis und Julien Vitores. „Telle sœur, tel frère ?“ Revue française de sociologie Vol. 64, Nr. 3 (30.05.2024): 471–513. http://dx.doi.org/10.3917/rfs.643.0471.
Der volle Inhalt der QuelleSt. John, Philip D., Patrick R. Montgomery und Suzanne L. Tyas. „Social Position and Frailty“. Canadian Journal on Aging / La Revue canadienne du vieillissement 32, Nr. 3 (20.08.2013): 250–59. http://dx.doi.org/10.1017/s0714980813000329.
Der volle Inhalt der QuelleAlbertsen, I. M., und J. J. Temprado. „Effet de la supplémentation haptique sur le contrôle postural en position debout perturbée“. Neurophysiologie Clinique/Clinical Neurophysiology 42, Nr. 6 (Dezember 2012): 385–86. http://dx.doi.org/10.1016/j.neucli.2012.09.003.
Der volle Inhalt der QuelleGreissler, Élisabeth. „L’engagement des jeunes en situation de marginalité : une part d’ombre ?“ Partie 1 — Les nouveaux canaux d’expression publique de l’arrière-scène participative, Nr. 71 (02.05.2014): 51–68. http://dx.doi.org/10.7202/1024738ar.
Der volle Inhalt der QuellePaché, Gilles. „Stratégies réticulaires et vulnérabilité de la petite entreprise : une illustration“. Revue internationale P.M.E. 9, Nr. 1 (16.02.2012): 7–20. http://dx.doi.org/10.7202/1008251ar.
Der volle Inhalt der QuelleDissertationen zum Thema "Effet de position télomérique"
Boussouar, Amina. „Effet de position télomérique et criblage moléculaire : vers de nouvelles cibles télomériques“. Lyon, Ecole normale supérieure, 2010. http://www.theses.fr/2010ENSL0597.
Der volle Inhalt der QuelleTelomeres are protective structures present at the ends of linear chromosomes and consist of simple repeated DNA sequences and specialized proteins. They are essential for the stable maintenance of eukaryotic chromosomes and they can regulate the lifespan of cells. In addition to their essential functions, telomeres are, in diverse organisms, specialized sites with regard to gene expression. Indeed, the transcription of genes located next to telomeres is repressed: this phenomenon was termed telomere position effect (TPE). As observed in the yeast, S. Cerevisiae -where TPE is best characterized- TPE in human cells depends of both telomere length and architecture. The treatment of cells with Trichostatin A, an inhibitor of class I and II histone deacetylases antagonizes TPE while treating the cells with 5-aza-2’-deoxycytidin, a demethylating agent, has no apparent effect on telomeric repression. Overall, position effects at human chromosome ends are dependent on a specific higher-order organization of the telomeric chromatin. In order to identify new molecules able to modulate TPE in human cells, we carried out the screening of the «Prestwick Chemical Library », a bank of bioactive molecules, on the CMBA-CEA platform in Grenoble. A total of 15 molecules were identified as anti-TPE factors after primary and secondary screening based on the increase in fluorescence measurement. After testing all of these molecules in our laboratory, two polyphenols, Acacetin and Chrysin, were retained as potent inhibitors of TPE and further characterized as drugs targeting telomeres specifically. We then asked whether TPE reversal was dependent on telomere length. The incubation in the presence of Acacetin and Chrysin affects telomere length suggesting that increased expression of the subtelomeric reporters is associated with a shortening of telomeres. To check whether these molecules revert telomeric silencing, by affecting telomere integrity, we analyzed chromosome stability in cells treated with Acacetin or Chrysin. The two molecules exhibit a rapid increase in the frequency of telomere induced DNA damage foci, suggesting that these drugs trigger telomeric dysfunction. Drug treatment also significantly increases the frequency of telomeric abnormalities observed in metaphase with a significant increase of end-to-end fusions between sisters chromatid. The discovery of these new compounds targeting specifically chromosome ends opens new avenue for the targeted treatment of diseases linked to telomeric pathways such as cancer but also rare diseases such as Facio-Scapulo-Humeral dystrophy for which we investigated the molecular mechanisms
Rey-Millet, Martin. „Les télomères, des éléments de régulation de la transcription dans les cellules sénescentes“. Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://www.theses.fr/2021COAZ6022.
Der volle Inhalt der QuelleTelomeres, the nucleoprotein structures located at the end of eukaryotic DNA, protect chromosomal integrity. These structures undergo changes during development and aging, including length shortening and alterations in the levels of the proteins associated to them called sheltering, all this affecting genome stability as the cells age. However, telomeres also behave as transcriptional regulators acting not only on genes present at subtelomeres but also on more distantly located genes presented throughout the genome. This process is referred as Telomere Position Effect (TPE) and was initially discovered in budding yeast, but also seen in drosophila, fission yeast, plasmodium and more recently in humans. In all these organisms, genes located in the subtelomeres are repressed by an epigenetic mechanism that is dependent on telomere DNA length, telomere nucleoprotein composition and higher order chromatin organization adopted by telomeres and subtelomeres. The TPE mechanism can be described as the spreading of a heterochromatin-like structure toward the centromere most likely accompanied by the formation of large chromatin loops to further extend the transcriptional regulation emanating from a telomere to genes internally located.In this context, the goal of my thesis is to decipher whether telomeres are involved in the transcriptional remodelling occurring in human cellular senescence. For that, we performed RNA-sequencing in young versus replicative senescent lung fibroblast MRC-5 cells. Interestingly, we found an enrichment of upregulated genes in the subtelomeric regions of senescent cells suggesting a TPE alleviation. This alleviation is not homogeneous in the genome, as only some subtelomeres were enriched in upregulated genes at senescence.Finally, we tested the hypothesis that shelterin proteins may also be part of the TPE regulation. For that, we re-stored the levels of the shelterin protein TRF2 (Telomeric Repeat Binding Factor 2) whose expression is decreased as the cells approach senescence. We found that TRF2 is indeed modulating the expression of subtelomeric genes in senescent cells, and this is in part mediated by a long-range chromatin reorganization of subtelomeres as observed by conformation changes in 3D chromatin conformation by FISH.Overall, this work reveals the contribution of telomeres in the transcriptional program of senescent cells and set the basis for the relevance of TPE in the senescence/aging process
Adamian, Nika. „Predictive position coding : attentional account of motion-induced position shifts“. Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB164/document.
Der volle Inhalt der QuelleLocalizing objects in space is one of the central functions of the visual system. When an observer or a target is moving, the motion of the eye or the object can be taken into account to compute the current object locations. It has been shown many times that visual motion can strongly influence the perceived position of an object. For example, a stationary patch containing moving texture (De Valois & De Valois, 199; Ramachandran & Anstis, 1990), a flash presented on (Cavanagh & Anstis, 2013) or next to (Whitney & Cavanagh, 2000) a moving texture, and even the onset and offset positions of the moving targets (Fröhlich, 1923) are perceived as shifted in the direction of motion. In this thesis we explore the relationship between these motion-induced position shifts and visual attention in the following forms: 1) transient spatial attention, 2) global and local attention, 3) sustained spatial attention, and 4) object-based attention. In the first series of experiments we looked at whether and how attention modulates the shift in localization of motion onset (Fröhlich effect). In Experiments 1 and 2 we measured Fröhlich effect under different cueing conditions and established that invalid or late cues produced larger perceptual shifts. In Experiment 3 we compare the motion-induced shifts when the subjects attended to a set of moving stimuli as a group and when they attended to an orientation singleton. We showed that the Fröhlich effect was only present when the target was individuated and disappeared when the stimulus was perceived globally. Thus, the Fröhlich effect appeared to be both produced and modulated by focal attention. Having established that temporal delays of attention increase motion-induced position shifts, the next study explored if spatial distribution of attention has a similar effect. In this study we used flash grab - an illusory position shift seen when a target is briefly flashed on top of a moving background that abruptly changes direction (Cavanagh & Anstis, 2013). Trials were presented in blocks and before each block a cue indicated a range of possible target locations. We found that the flash grab was reduced if the spatial distribution of targets was limited to a range of 90° or less. The final study asked whether motion shifts the perceived position of an object as a whole or if separate features of a single object are shifted independently. To test this we used the flash grab paradigm and briefly presented a shape on top of a moving background at the moment it changed direction. The results showed that the features of the target that were orthogonal to the background motion were shifted, whereas the features parallel to the motion were intact. This suggests that motion interacts with the position of the object's features (and focal attention selects them) before they are bound together into an object. In conclusion, we applied a variety of attentional manipulations to motion-induced position shifts, and examined the link between the strength of the illusion and the characteristics of attention used in a particular task. We found that 1) motion-induced position shifts require focused attention and the possibility to track an individual motion trajectory; 2) allowing attention to be allocated more efficiently in space reduces the illusion; and 3) motion-induced shifts operate on the feature-based and not object-based level
Moraine, Jean-Jacques. „Le débit sanguin cérébral dans les affections neurologiques aiguës: effet de la position“. Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211594.
Der volle Inhalt der QuellePeltier, Jean-David. „Isomères de position d’indacénodithiophènes : synthèse, propriétés et applications en transistors organiques à effet de champ“. Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1S138/document.
Der volle Inhalt der QuelleOrganic Field Effect Transistors (OFETs), in which the charge transport is carried through a thin film made of organic molecules represent a transformation of the FET technology regarding that based on Silicon. They offer in particular the possibility to manufacture low cost flexible electronics. This work is focused on the synthesis, the study and the use as active layer in n-type OFETs of novel, electron poor, couples of para- and meta-indacenodithiophenes isomers (para- and meta-IDT). First of all, an introduction to the field of n-type OFETs is presented, followed by the presentation of the synthesis of the IDT derivatives and the comparative analysis of their properties. Finally, the fabrication of the OFETs, their characterization and the optimization of their architecture is described. The performances recorded attest that these derivatives are of great interest for the n-type OFETs. Different 3π-2spiro IDT derivatives are also presented in order to study the IDTs intrinsic properties and to envisage their incorporation as host in phosphorescent organic light-emitting diodes
Haddad, Darine. „Mesure et contrôle de position et de vitesse à l'échelle nanométrique : application à la balance du watt“. Versailles-St Quentin en Yvelines, 2004. http://www.theses.fr/2004VERS0018.
Der volle Inhalt der QuelleThe aim of this work is to control the position and the velocity of a moving mass with a nanometric accuracy on a translation range of 80 mm. For the velocity, the objective is to obtain a stability of 10-9 in relative value. The essential application is the watt balance of the Bureau National de Métrologie. A novel method was developed and implemented, based on the use of both a heterodyne Michelson's interferometer and a home made electronic circuit. The interferometric system is associated to a mechanical system of double translation stages made up of a linear stage and a piezoelectric actuator. Displacement of 4. 945 nm was controlled and measured with repeatabilities and accuracies less than the nanometer. Results show that relative uncertainty of 10-9 on velocity can be reached
Lecomte, Vincent. „Préparation d'androst-5-ènes modifiés en position 11 via l'étude de la réactivité de cétones énolisables et d'alcools tertiaires en série encombrée“. Phd thesis, Paris 6, 2004. http://pastel.archives-ouvertes.fr/pastel-00001108.
Der volle Inhalt der QuelleBarbot, Willy. „Variation circadienne et induction avec l'âge de l'expression d'un rétrotransposon IAP de souris : caractérisation du site d'insertion proviral et "effet de position"“. Paris 6, 2002. http://www.theses.fr/2002PA066022.
Der volle Inhalt der QuelleIannuzzi, Stéphanie. „Les effets lexicaux dans l'identification de la lettre : étude en potentiels évoqués chez des enfants normo-lecteurs et dyslexiques“. Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1276/.
Der volle Inhalt der QuelleOrthographic processes that take place during visual recognition of letter sequences can be dissociated into three different stages activated in an interactive and parallel manner : visual feature analysis, letter processing and letter sequence processing. The lexical influences on letter identification have often been observed with the well-known Word Superiority Effect : a letter is better identified when presented in words than in non-words or in isolation. One aim of this study was to understand which processing stages are influenced by lexical knowledge during reading acquisition. To do this, we performed an Event-Related Potential study with dyslexic children and typically achieving ones. The task consists in identifying a letter presented in a word or a non-word. Furthermore, it is well accepted that, in alphabetic and left-to-right languages, words are better identified when fixated slightly left of the center. Our task was designed in such a way that we were able to study this Optimal Viewing Position. The aim was to analyse if the lexical influences intervene in the same manner for all position in the word. Our behavioral results show a Word Superiority Effect only for typically achieving children suggesting influences of the lexical knowledge for them. We hypothesise that dyslexics present a deficit on these "top-down" lexical influences. Analyses based on the position do not show the Optimal Viewing Position expected. The results are similar in both groups with a diminution of the performance between the first and the last position. It suggests a serial and automatic processing of the stimuli from left to right whatever the fixation point. The firsts ERPs differences between words and non-words appears on the N2 reflecting the lexical processing and the same effect is shown in both groups. The lack of effect on the N170 is in disagreement with the hypothesis of lexical influences on letter identification at a pre-lexical level
Guillemot, Laurent. „Les processus de captures électroniques multiples par des ions multichargés lors de collisions sur des cibles atomiques neutres : étude critique du modèle moléculaire de la barrière coulombienne“. Paris 11, 1989. http://www.theses.fr/1989PA112380.
Der volle Inhalt der QuelleBuchteile zum Thema "Effet de position télomérique"
Hatem, Jad. „Temps et seuil“. In D'un seuil à l'autre, 107–13. Editions des archives contemporaines, 2017. http://dx.doi.org/10.17184/eac.764.
Der volle Inhalt der QuelleOlou, Mahougbè Abraham. „Le système pronominal de l’ajagbè : analyse morphosyntaxique“. In Langues, formations et pédagogies : le miroir africain, 89–103. Observatoire européen du plurilinguisme, 2018. http://dx.doi.org/10.3917/oep.agbef.2018.02.0089.
Der volle Inhalt der QuelleKonferenzberichte zum Thema "Effet de position télomérique"
Yamlamai, Nicha, und Thi Thuy Hien Tran. „Effet de la position de la syllabe sur la réalisation acoustique des consonnes finales du thaï“. In XXXIIe Journées d’Études sur la Parole. ISCA: ISCA, 2018. http://dx.doi.org/10.21437/jep.2018-18.
Der volle Inhalt der QuelleSonesson, Göran. „Rhetoric from the standpoint of the Lifeworld“. In Le Groupe μ : quarante ans de rhétorique – trente-trois ans de sémiotique visuelle. Limoges: Université de Limoges, 2010. http://dx.doi.org/10.25965/as.3106.
Der volle Inhalt der QuelleBerichte der Organisationen zum Thema "Effet de position télomérique"
Gruber, Verena, Ingrid Peignier und Elinora Pentcheva. Analyse des motivations d’achat de camions légers au Québec. CIRANO, Februar 2023. http://dx.doi.org/10.54932/kzyi1849.
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