Dissertationen: „Effector design“

1

Fateh, Mohammad Mahdi. „End effector design and control“. Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342764.

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2

Chorley, Craig Stephen. „Glabrous skin structures for tactile end effector design“. Thesis, University of the West of England, Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603326.

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Unique to the sense of touch is that it is created through physical interaction. Through exploring the world with our skin we discover its properties, its shape, textures and materials, allowing us to meaningfully interact with it. This places great emphasis on the mechanical properties of our skin, the organ of touch, and no more so than the 'glabrous' skin of the finger pads and palms of our hands. Through a wide and multi-disciplinary review of touch, and observations of the macro and microstrutures of glabrous skin, this thesis develops an understanding of the key mechanical properties of this specialised skin, and presents a new hypothesis for the existence of an edge-encoding functional morphology. This thesis presents significant benefits to tactile end effector design that can be gained through mimicking the key mechanical structures of human glabrous skin. A new tactile end-effector design is presented and tested, which successfully demonstrates the capture of these key functional properties, creating a highly sensitive and accurate extraction of tactile features from a touched scene. This prototype device is both a practical and highly capable tactile sensing end effector. It achieves significant levels of compliance, sensitivity, contact surface area and strength for practical use in active exploration, and in grasping and manipulation of objects. The prototype device is strong, robust, reliable, simple and cheap to manufacture

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Dean, David L. „Design of a robotic end-effector for automated bolting“. Thesis, Massachusetts Institute of Technology, 1985. http://hdl.handle.net/1721.1/100065.

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Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1985.
MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING
Bibliography: leaf 111.
by David L. Dean, Jr.
M.S.

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4

Åman, Robin. „Design of an End Effector for Drilling in Automated Processes“. Thesis, Linköping University, Department of Mechanical Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7323.

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In an attempt to solve a problem concerning drilling, a project was started at the universities in Linköping and Lund. As a part of the project this thesis aims to help solve the drilling problem. The goal of this thesis is to design an end effector that will help avoid slipping when drilling. The methods used were taken from David G. Ullman’s book The Mechanical Design Process. Members involved in the project were interviewed to get an understanding of the task. With that done the concept generation phase began, resulting in several concepts. With the use of evaluation methods, such as feasibility judgment and Go/No-Go screening, a final concept emerged. All of the parts and details of the concept were designed with respect for the customers’ requirements and demands.

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5

Cannon, Bennion Rhead. „Design and Analysis of End-Effector Systems for Scribing on Silicon“. BYU ScholarsArchive, 2003. https://scholarsarchive.byu.edu/etd/95.

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This thesis investigates end-effector systems used in a chemomechanical scribing process. Chemomechanical scribing is a method of patterning silicon to selectively deposit a monolayer of material on the surface of the silicon. This thesis details the development of a unique end-effector for chemomechanical scribing using a compliant mechanism solution. The end-effector is developed to scribe lines that have uniform geometry and produce less chipping on the surface of the silicon. The resulting scribing mechanism is passively controlled, has high lateral stiffness, and low axial stiffness. The mechanism is analyzed using the pseudo-rigid-body model and linear-elastic beam method to determine the axial stiffness, finite element methods to determine the lateral stiffness, and fatigue analysis to determine mechanism cycle life. This thesis also investigates the significance of mechanical factors on the chemomechanical scribing process using the compliant end-effector. The factors examined are scribing force, scribing speed, tip geometry, wafer orientation, and wetting liquid. The factors are analyzed using a two-step approach: first, an analysis of the influence of the mechanical factors on line characteristics and second, an analysis of the influence of line characteristics on line performance.

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Cannon, Bennion R. „Design and analysis of end-effector systems for scribing on silicon /“. Diss., CLICK HERE for online access, 2003. http://contentdm.lib.byu.edu/ETD/image/etd259.pdf.

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7

Socha, Kevin G. „Design of a compliant end effector for grasping non-rigid materials“. Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/17986.

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8

Kallenbach, Loren R. „Design and implementation of an end effector for the integrated intelligent belt manipulator“. Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/16706.

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9

Venieri, Marco. „End-effector of a robotic arm for a planetary rover: the European Rover Challenge experience“. Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20311/.

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La tesi tratta lo sviluppo di un prototipo di end-effector di un braccio robotico per un rover spaziale al fine di partecipare ad autunno alla European Rover Challenge. Dopo aver analizzato i task richiesti dal regolamento della competizione, è stata analizzata la miglior tipologia di gripper da utilizzare, con conseguente progettazione del cinematismo di movimentazione e scelta dei materiali idonei. L’attenzione si è poi spostata all’elettronica di controllo del motore e alla scelta della sensoristica necessaria.

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Gore, Kiron Pralhad. „Design, fabrication and testing of a special purpose end effector for the task of bin-picking“. Thesis, Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/16954.

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11

Robinson, Graham. „The mechanical design and evaluation of Amadeus #2 a dextrous continuum end-effector for marine intervention“. Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/451.

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12

Srdošová, Michaela. „Návrh robotické buňky pro manipulační operace“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400982.

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This Master`s thesis deals automation of the workplace for manipulation operations. Robot’s role is take cooler from case, insert them into the dimensional and tightness device and then robot must place cooler on the output conveyor in robotic cell. The thesis describe deployment working cell, the selection and design process of each device and the robotic cell is designed with the safety standards. On the end in this thesis is a technical-economics evaluation. The simulation model in Process Simulate is a aim of this thesis, because we know working cycle time from this model.

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Tarnoff, David. „Episode 2.7 – The Effect of Sampling Rates on Digital Signals“. Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/computer-organization-design-oer/13.

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Converting an analog signal to digital involves more than just digitizing some measurements. Consequences result from sampling an analog signal and care has to be taken to capture all the desired frequencies and avoid creating new ones.

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Kliiman, Kristin, und Annie Ekblom. „The effect of constraints in creativity : From the perspective of web designers“. Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Datateknik och informatik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-43643.

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Purpose – Web is no longer solely about functionality and information as it used to be. Nowadays the aesthetic aspects, including creativity, could be considered just as important. However, web designers still need to fulfil the needs of clients and users in the design process which causes various design constraints. Therefore, this study aims to investigate how web designers’ creativity is affected by various design constraints. This is explored by one main research question and a sub-question: 1.) How is web designers’ creativity affected by design constraints?; 1.1) What could cause web designers to break web design guidelines? Method – This research applied an inductive, qualitative approach with an exploratory view. In order to find answers for the research questions, semi-structured interviews were conducted with 8 participants from the field of web design. The data gathered was later analysed and evaluated through thematic analysis Conclusions – The findings of this study suggest that while there are some positive effects, web designers’ creativity is mostly negatively affected by design constraints. Furthermore, it seems web designers break web design guidelines due to finding them irrelevant and/or to get a more creative outcome as well as breaking them unintentionally. Delimitations – This study only covers how web designers reason regards the research questions and does not include the perspective of web developers. Moreover, this thesis focuses solely on website design and does not involve design for mobile applications.

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Rusňák, Filip. „Návrh robotické buňky pro obsluhu obráběcího stroje“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-444304.

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The master thesis deals with design of a robotic workcell for the operating of CNC lathe. The material input is realized by bin picking technology. The first part is an overview of related industries. Three variants of the workcell layout were created in the second part and the most suitable variant was selected. Selected variant is further elaborated, including 3D models of the workplace parts and drawings. The functionality of the designed workcell is checked by Siemens Process Simulate software simulation. The technical and economical evaluation is performed at the final part of the thesis.

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Phillips, Stanley D. „Developing radiation hardening by design“. Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29640.

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Thesis (M. S.)--Electrical and Computer Engineering, Georgia Institute of Technology, 2010.
Committee Chair: Cressler, John; Committee Member: Citrin, David; Committee Member: Shen, Shyh-Chiang. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Cory, Mark. „CONVENTIONAL AND ZVT SYNCHRONOUS BUCK CONVERTER DESIGN, ANALYSIS, AND MEASUREMENT“. Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2759.

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The role played by power converting circuits is extremely important to almost any electronic system built today. Circuits that use converters of any type depend on power that is consistent in form and reliable in order to properly function. In addition, todayÂ s demands require more efficient use of energy, from large stationary systems such as power plants all the way down to small mobile devices such as laptops and cell phones. This places a need to reduce any losses to a minimum. The power conversion circuitry in a system is a very good place to reduce a large amount of unnecessary loss. This can be done using circuit topologies that are low loss in nature. For low loss and high performance, soft switching topologies have offered solutions in some cases. Also, limited study has been performed on device aging effects on switching mode power converting circuits. The impact of this effect on a converterÂ s overall efficiency is theoretically known but with little experimental evidence in support. In this thesis, non-isolated buck type switching converters will be the main focus. This type of power conversion is widely used in many systems for DC to DC voltage step down. Newer methods and topologies to raise converter power efficiency are discussed, including a new synchronous ZVT topology . Also, a study has been performed on device aging effects on converter efficiency. Various scenarios of voltage conversion, switching frequency, and circuit components as well as other conditions have been considered. Experimental testing has been performed in both cases, ZVTÂ s benefits and device aging effects, the results of which are discussed as well.
M.S.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Electrical Engineering MSEE

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Murteza, Noor Danielle. „Designer Fractal Patterns: Ecological Validity and the Psychological Wellbeing Effect of Fractal Patterns in Interior Spaces“. The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu159422878465947.

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19

Zhang, Jianjun, und j3029709 zhang@gmail com. „Precise Velocity and Acceleration Determination Using a Standalone GPS Receiver in Real Time“. RMIT University. Mathematical and Geospatial Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080121.142357.

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Precise velocity and acceleration information is required for many real time applications. A standalone GPS receiver can be used to derive such information; however, there are many unsolved problems in this regard. This thesis establishes the theoretical basis for precise velocity and acceleration determination using a standalone GPS receiver in real time. An intensive investigation has been conducted into the Doppler effect in GPS. A highly accurate Doppler shift one-way observation equation is developed based on a comprehensive error analysis of each contributing factor including relativistic effects. Various error mitigation/elimination methods have been developed to improve the measurement accuracy of both the Doppler and Doppler-rate. Algorithms and formulae are presented to obtain real-time satellite velocity and acceleration in the ECEF system from the broadcast ephemeris. Low order IIR differentiators are designed to derive Doppler and Doppler-rate measurements from the raw GPS data for real-time applications. Abnormalities and their corresponding treatments in real-time operations are also discussed. In addition to the velocity and acceleration determination, this thesis offers a good tool for GPS measurement modelling and for design of interpolators, differentiators, as well as Kalman filters. The relativistic terms presented by this thesis suggest that it is possible to measure the geopotential directly using Doppler shift measurements. This may lead to a foundation for the development of a next generation satellite system for geodesy in the future.

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Wiggins, Emily C. „CREATING VISUAL EFFECT: A DESIGN INSTRUCTION TOOL FOR IDENTIFYING COMPOSITIONAL THEORY COMPONENTS FOR INTERIOR DESIGN“. The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338321795.

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21

Atilola, Olufunmilola O. „The effects of representation and analogy on engineering idea generation“. Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53436.

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The use of examples in idea generation is a common practice intended to provide inspiration from existing products to the designing of new ones. Examples can be taken from the Internet, engineering textbooks, analogical databases, literature, a company’s prior designs, or from a competitor company, prior work by the designer, and many other sources. These examples are represented in various ways, such as hand sketches, pictures, computer-aided designs (CAD), physical models, activity diagrams, shape grammars, text descriptions, etc. Design representations can also be broken down by function in the form of functional models and decompositions. The use of these visual or physical examples allows engineers to get a clearer picture of how a design or component works and enables them to have a better understanding of the overall design and function. Each representation has inherent advantages and disadvantages in the way that they portray a design. Examples are sources for analogies. Analogies from nature, where biological organisms have solved challenging problems in novel ways, are very useful in engineering idea generation and solution retrieval. This process is called biologically inspired design. Engineers often use biologically inspired design to solve problems while increasing creativity and expanding the solution space. Using this method, engineers are able to learn from nature and apply biological principles to real world engineering problems to make effective designs and produce innovative solutions. It is important to have a clearer understanding of how the use of the representations and characteristics of examples as external stimuli affect the idea generation process in engineering design. Understanding these processes will be invaluable in offering guidelines for how engineering design should be done and what types of external stimuli should be used to allow for innovation and creativity to be enhanced. This dissertation presents four studies that focus on understanding ways that examples can be used to improve the idea generation process. Three of these studies focus on how the representation of externally imposed examples, which may be used as analogues, influences creativity during idea generation while also minimizing design fixation, which occurs when designers adhere to the features of their own initial design solutions or to features of existing examples. The fourth study focuses on the use of examples as sources for analogical mapping and how these examples produce innovative solutions during idea generation. The first study compares CAD, sketch, and photograph representation presented individually. The second study compares CAD and sketch representation presented together, and the third study examines function tree and sketch representations. The fourth study looks at the real-world context and impact of examples used as sources for analogical mapping to inspire innovative solutions. The results of the studies show that CAD representations of good examples are effective in allowing engineers to identify the key working principles of a design and help to develop higher quality design concepts. CAD representations also cause more fixation to the example’s features. Function trees do not cause nor break fixation compared to a control condition, but do reduce fixation compared with sketches. Biological examples can be successfully used as analogues during engineering idea generation to create novel and effective design solutions to relevant and real-world engineering problems.

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Diestelhorst, Ryan M. „Silicon-germanium BiCMOS device and circuit design for extreme environment applications“. Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28180.

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Thesis (M. S.)--Electrical and Computer Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Cressler, John; Committee Member: Papapolymerou, John; Committee Member: Ralph, Stephen.

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Lord, Joseph Louis Martin. „FET upconverter design using load dependent mixing transconductance“. Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28499.

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The conversion gain of GaAs MESFET mixers is known to be dependent on the impedances seen by the applied signals and the resulting mixing products at all ports of the device. For an accurate representation, all these loading conditions should be considered; however, the design of gate and drain networks then becomes rather difficult. As a result, no sufficiently accurate and yet usable design procedures exist for MESFET mixers; instead, a few simple rules involving short- and open-circuit terminations have been given by various authors. Unfortunately, these rules are often inappropriate, particularly in upconverter applications. In this thesis, the conversion efficiency dependence on the drain loading at the local oscillator frequency has been studied for a gate upconverter; the local oscillator signal is by far the most dominant in terms of its influence on mixer performance. It has been found that the conversion gain can significantly deteriorate for a narrow range of load values. In addition, the local oscillator drain termination resulting in highest gain has been found to be generally different from the short-circuit recommended in the literature. Based on these findings, a novel FET upconverter design procedure has been developed that incorporates the local oscillator loading phenomenon in the FET equivalent circuit by means of a load dependent mixing transconductance. It allows the optimization of the drain network for an acceptable match at the selected sideband and desired local oscillator rejection while avoiding impedance values in the local oscillator frequency range which would otherwise cause severe degradation in conversion gain.
Applied Science, Faculty of
Electrical and Computer Engineering, Department of
Graduate

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24

Ataman, Osman. „Media effect on architectural design“. Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/23925.

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25

Zetterblom, Margareta. „Textile Sound Design“. Doctoral thesis, Högskolan i Borås, Institutionen Textilhögskolan, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3588.

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The thesis aims at developing conceptual and methodological tools in order to adapt sound in a “designerly” way within the discipline textile design. Occupational groups working with sound are to a large extent problem driven. This implies knowledge regarding sound and sound design mostly focuses on defensive strategies, not creative possibilities. The ambition with this research project is to make suggestions how textile designers can work practically with textile sound design, in a more nuanced way. /br As a starting point the thesis describes commonly used methods and processes used in the design process within an industrial context, followed by a more thorough analyze of the textile design process. These studies constitute a foundation to make it possible to see in what way these methods and processes will be affected when sound is added as new design tool./br By studies of two sound design models, the first attempts to develop a vocabulary concerning how to describe sound affecting qualities or sound expression of a textile are presented. Research focusing on language issues, especially on the development of conceptual tools done at the research institute Cresson, provides descriptive concepts, “sound effects”, embracing the interaction between human and his sound environment. These concepts are followed by a model of how to describe a “sound object” in “itself” (not in relation to anything else), developed by Pierre Schaeffer./br The theoretical models have been applied on the outcome of an phenomenological study named Describe. A number of design examples are finally presented as methodological examples of different ways to work with textiles and sound./br Keywords: sound, design, textile design, sound effect, sound object.
Thesis to be defended in public at 24 May 2011 at 13.00, at the Gallary floor 2, The Swedish School of Textiles, Bryggaregatan 17, Borås, for the degree of Philosophy.

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Léo, Smith. „The Effect of Dynamic Music in Video Games : An Overview of Current Research“. Thesis, Uppsala universitet, Institutionen för speldesign, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414409.

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27

Moëll, Caroline. „JERSEY, SURE ! : Special developed jersey knits with color effects“. Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-13030.

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This study investigates the effect of single jersey, based on its original formas a cylinder. It is also an investigation of color and transforming surfaceof garment.The outfits are based on the cylinder in construction. With some cuts andseams, developed into garments. The surface of the fabric has qualities recognizable to rib, but the constructionis different. By using cotton and polyester yarns, the stripesshrinks in different directions and when the body integrates with thefabric, shape, gravity and movement will make the material transform byopen and closing the lines. Different color effects are presented in the collection. The result is suggestingdifferent color effects, depending on size of the stripes, the saturationof the colors and the placement on the body.

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Maleki, Laleh. „How to get changing patterns on a textile surface by using thermo chromic pigments and an inherently conductive polymer“. Thesis, Högskolan i Borås, Institutionen Textilhögskolan, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-17453.

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With regard to the recent interests in smart textiles,this research activity has been conducted with the aim of producing a pattern changing design on textiles. In order to fulfill the demands of such dynamic patterns a combinationof conductive polymer and thermochromic pigments wereused. The textile substrate was coated by conductive polymer dispersion(PEDOT:PSS) and it was followed with printing thermochromic pigments on the surface of coating.The driving force of such thermochromic reaction has to be provided by the heat generated from conductive layer dueto the current of electricity passing through the conductivelayer. These experiments were continued by changing thecoating recipe in order to achieve the highest possible electrical resistance,which leads to the best initiation ofthermochromic reactions.
Program: Master programme in Textile Technology

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Åhlund, Viktor. „Designing for Engagement: Effects of Social Features in Mobile Manager Games“. Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177435.

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Mobile gaming was in 2019 the biggest revenue-creating area of gaming, beating all other forms of gaming combined. Despite this, mobile manager games are still a fairly unexplored genre. The thesis explores the area of social features in these kinds of games. Studies around the success of social networks, engaging features in mobile apps and good UX practices in mobile games were made. These findings together with a questionnaire with 87 participants created a framework of how a social feature should look like when implementing into a manager game. The feature, Social League, was designed and implemented in the game World Football Manager created by Gold Town Games. The feature is available from Friday’s through Sunday’s. Data was collected from World Football Manager prior to the implementation of Social League to get measurable data. The most central data was average game time of the players. Six weeks after Social League got implemented, the thesis studied the app and the updated data. The result showed a moderate increase of player session during the whole week, 7.3%. While looking exclusively on weekends, the average session increased by 15%, a major increase. This suggests that an introduced social aspect should increase the engagement of users in a mobile manager game.

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Tyll, Jason Scott. „Concurrent Aerodynamic Shape / Cost Design Of Magnetic Levitation Vehicles Using Multidisciplinary Design Optimization Techniques“. Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/40514.

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A multidisciplinary design optimization (MDO) methodology is developed to link the aerodynamic shape design to the system costs for magnetically levitated (MAGLEV) vehicles. These railed vehicles can cruise at speeds approaching that of short haul aircraft and travel just inches from a guideway. They are slated for high speed intercity service of up to 500 miles in length and would compete with air shuttle services. The realization of this technology hinges upon economic viability which is the impetus for the design methodology presented here. This methodology involves models for the aerodynamics, structural weight, direct operating cost, acquisition cost, and life cycle cost and utilizes the DOT optimization software. Optimizations are performed using sequential quadratic programming for a 5 design variable problem. This problem is reformulated using 7 design variables to overcome problems due to non-smooth design space. The reformulation of the problem provides a smoother design space which is navigable by calculus based optimizers. The MDO methodology proves to be a useful tool for the design of MAGLEV vehicles. The optimizations show significant and sensible differences between designing for minimum life cycle cost and other figures of merit. The optimizations also show a need for a more sensitive acquisition cost model which is not based simply on weight engineering. As a part of the design methodology, a low-order aerodynamics model is developed for the prediction of 2-D, ground effect flow over bluff bodies. The model employs a continuous vortex sheet to model the solid surface, discrete vortices to model the shed wake, the Stratford Criterion to determine the location of the turbulent separation, and the vorticity conservation condition to determine the strength of the shed vorticity. The continuous vortex sheet better matches the mechanics of the flow than discrete singularities and therefore better predicts the ground effect flow. The predictions compare well with higher-order computational methods and experimental data. A 3-D extension to this model is investigated, although no 3-D design optimizations are performed. NOTE: An updated copy of this ETD was added on 05/29/2013.
Ph. D.

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Michie, Stephen Neil. „A design methodology for circulation control manoeuvre effectors“. Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498974.

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32

Monet, Damien. „Identification de nouvelles voies d'inhibition ciblant les mouvements fonctionnels de protéines : application à la transition allostérique du récepteur nicotinique de l'acétylcholine“. Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS206.

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L'étude de la dynamique fonctionnelle de protéines impliquées dans des processus pathologiques et des évolutions associées de leurs cavités et poches, offre de nouvelles stratégies pour le dessin de molécules effectrices. Ce travail décrit la transition d'activation d'un récepteur nicotinique de l'acétylcholine, le sous-type (a7)5, qui est impliqué dans des processus cognitifs et certains désordres neurodégénératifs, ce qui en fait une cible thérapeutique de choix. Le processus d'activation du récepteur a été modélisé par une série de conformations intermédiaires reliant les états de repos et actif. Notre modèle de transition reproduit correctement les mouvements quaternaires connus, le blooming et le twisting. Parallèlement, nous avons mis au point un algorithme robuste permettant de donner une vision unitaire des cavités issues de conformations structurales différentes. Ces groupes cohérents de cavités définissent des poches, sites potentiels pour la liaison de ligands. Un programme, mkgridXf, implémente le suivi des cavités et l'identification cohérente de sites sur les trajectoires de protéines. La cartographie des cavités de la transition (a7)5 a révélé 6 sites dont le volume varie de façon significative avec l'état conformationnel. Parmi eux, nous retrouvons le site orthostérique, le site modulateur Ca2+ ainsi que 2 sites allostériques précédemment décrits. L'amarrage moléculaire de modulateurs allostériques sur les structures de la transition permet de proposer l'existence d'un site de liaison transmembranaire. Ces données suggèrent de nouvelles routes de dessins d'effecteurs ayant des activités ciblées
The analysis of the functional motion of proteins involved in various diseases and the associated evolution of cavities and grooves offers novel strategies to identify effector molecules. This work describes the gating mechanism of a nicotinic acetylcholine receptor, the (a7)5 subtype, involved in cognitive processes and various neurological disorders. The activation mechanism has been modeled by a series of intermediate conformations linking the resting and the active states of the receptor. Our transition model correctly reproduced the known quaternary motion, the blooming and the twisting. We also developed a robust algorithm to consistently track cavities in protein dynamics. Groups of protein cavities define pockets, potential binding sites for small molecules. A practical implementation, mkgridXf, is given to automatically track and identify sites in protein trajectories. The complete mapping of cavities on the (a7)5 transition structures revealed 6 distinct sites with a volume varying significantly with the conformational state of the protein. Among them, we found the orthosteric site, the Ca2+ modulatory site and 2 previously described allosteric sites. The molecular docking of allosteric modulators along the gating transition suggested the existence of an effector transmembrane site. These results paves the way toward the design of drugs with targeted activities

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McCloughan, Catherine Lucy Brigid. „Luminous effects upon mood and decision making“. Thesis, Heriot-Watt University, 1996. http://hdl.handle.net/10399/1090.

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Ahmed, Al-Obeidi Fahad. „Design, synthesis, conformation and biological activities of cyclic alpha-melanotropin and related compounds“. Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184445.

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This research initiated an investigation of the structural relationships between melanocyte stimulating hormone (α-MSH) and its melanin dispersion on lizard (Anolis carolinensis) and frog (Rana pipiens) skins bioassays as representing models for mammalian and amphibian melanocytes, respectively. From previous extensive structure-activity relationships of α -MSH together with the theoretical modeling we were able to design a group of linear and cyclic peptides related to "4-10" fragment analogues of α -MSH. The solid phase synthesis of α -MSH and its related analogues using the p-methyl-benzhydrylamine resin was accomplished. The C-terminal carboxamide and N-terminal acetylamide were maintained in all peptides synthesized. The cyclic peptides were prepared in solution phase using the linear peptides generated by solid phase. All the cyclization were done by using the hydrochloride salts of the peptide and DMF as solvent with diphenylphosphoryl azide (DPPA) as a coupling reagent in the presence of K₂HPO₄ as a base. The yields of the cyclic peptides were in the range of 30-40 percent. In all the synthesized peptides the replacement of D-Phe⁷ with L-Phe⁷ causes reduction in the potency of the peptide on lizard or frog skins bioassays. Also, the reduction or increase in ring size in the cyclic peptide from a 23 membered ring diminishes the biological effect of the peptide under testing.

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Li, Chen, und Zhang Qi-shan. „HARDWARE SYSTEM DESIGN FOR VEHICLE NAVIGATOR“. International Foundation for Telemetering, 2002. http://hdl.handle.net/10150/607558.

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International Telemetering Conference Proceedings / October 21, 2002 / Town & Country Hotel and Conference Center, San Diego, California
This paper introduces the essential points for designing a navigating system, and describes the modules of a typical vehicle navigator. This paper also gives a practical navigator example. Some experience for design is also mentioned.

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Muthukumar, Susendar. „Effects of seismic pounding and restrainers on the ductility demands of multiple frame bridges“. Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/19139.

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Filiatrault, Andre. „Seismic design of friction damped braced steel plane frames by energy methods“. Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28776.

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The investigation described in this thesis represents the first known attempt to develop a simplified method for the seismic design of structures equipped with a novel friction damping system. The system has been shown experimentally to perform very well and is an exciting development in earthquake resistant design. The design of a building equipped with the friction damping system is achieved by determining the optimum slip load distribution to minimize structural response. A new efficient numerical modelling approach for the analysis and design of Friction Damped Braced Frames (FDBF) is presented. The hysteretic properties of the friction devices are derived theoretically and included in a Friction Damped Braced Frame Analysis Program (FDBFAP), which is adaptable to a microcomputer environment. The optimum slip load distribution is determined by minimizing a Relative Performance Index (RPI) derived from energy concepts. The steady-state response of a single storey friction damped structure subjected to sinusoidal ground motion is investigated analytically. Basic design information on the optimum slip load for the friction device is obtained. The parameters governing the optimum slip load, which minimizes the amplitude for any forcing frequency, are derived. The study indicates that the optimum slip load depends on the characteristics of the ground motion and of the structure. Using variational principles on a shear beam analogy, an optimum slip load distribution along the height of the structure is derived when the total amount of slip load is specified. It is shown that the optimum slip load is proportional to the slope of the deflected shape of the structure. The results of the study reveal that only a small improvement in the response is obtained by using this optimum distribution compared to the response obtained with a uniform distribution. Therefore the use of an optimum uniform distribution seems adequate for the design of friction damped structures. Taking into account the analytical results obtained, FDBFAP is then used in a parametric study which leads to the construction of a design slip load spectrum. The spectrum depends on the properties of the structure and ground motion anticipated at the construction site. It is believed that the availability of this design slip load spectrum will lead to a greater acceptance by the engineering profession of this new and innovative structural concept.
Applied Science, Faculty of
Civil Engineering, Department of
Graduate

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Zhou, Feng. „Viral product design for social network effects“. Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53067.

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Recent advances in social media have profound technical and economic implications for innovative design. This research is motivated to investigate social network effects on product design with a focus on the interface of engineering design, viral marketing, and social computing. This dissertation envisions a new paradigm of design, called viral product design for social network effects. The research problem is formulated as identification of both an optimal set of product configurations and an optimal set of seed customers so as to maximize product adoption via online social networks through equilibrium solutions to marketing-engineering coordination. Fundamental issues are investigated and a technical framework is proposed with integrated decision-based design methods. Results of case studies demonstrate that the proposed research is able to bridge the gaps between the domains of engineering design and viral marketing by incorporating social network effects. The proposed work is geared towards new design theory and decision models by integrating peer influence of social networks, which shed light on understanding the social aspect of design. The dissertation reveals the fundamental issues underlying viral product design, including the identification of viral attributes, customer preference modeling incorporating subjective experiences, the dynamics of the diffusion mechanism of online social networks, formulation of adoption maximization, and coordination between the marketing and engineering domains. In order to tackle the fundamental issues, a technical framework of viral product design for social network effects is proposed. Accordingly, mathematical and computational models are developed within the framework to support 1) latent customer needs elicitation for viral product attributes extraction, 2) customer preference modeling and quantification for product choice decision making, 3) social network modeling for product adoption prediction, and 4) viral product design evaluation by adoption maximization. These coherent models along the technical framework lay the theoretical foundation of this research, as described below. First, in order to extract potential viral product attributes, latent customer needs elicitation is emphasized. This is because latent customer needs can delight customers unexpectedly, and thus lead to potential product adoption to a large extent. We propose to elicit latent customer needs by use case analogical reasoning from sentiment analysis of online product reviews. A case study of Kindle Fire HD tablets shows the potential and feasibility of the proposed method. The extracted product attributes and attribute levels provide the choice set of viral product attributes. Second, based on the extracted product attributes, a customer preference model based on cumulative prospect theory is presented, accommodating subjective experiences in the product choice decision making process. Moreover, a hierarchical Bayesian model with Markov chain Monte Carlo is used to estimate parameters involved in the model. Based on the case study of aircraft cabin interior design, the model parameters under different experimental conditions show systematic influence of subjective experiences in choice decision making. Furthermore, a copula structure is used to construct a holistic product utility, showing customers' overall preferences to a product. This measure is crucial to product choice decision making in the context of social networks. Third, in order to predict product adoption incorporating peer influence of social networks, a linear threshold-hurdle model is proposed. It overcomes multiple drawbacks of traditional diffusion models by modeling activation thresholds, influence probability, adoption spread, holistic utility of the product, and hurdle utility of a customer in a holistic fashion. A case study of Kindle Fire HD tablets demonstrates both the predictive power of the proposed model and interesting results about customers' adoption behavior. This model paves the way for product adoption maximization in large social networks. Fourth, in order to coordinate between marketing-engineering concerns, I formulate a bi-level game theoretic optimization model for viral product design evaluation, in which the leader maximizes product adoption, while the follower optimizes product line performance. Through social network effects in terms of viral product attributes and viral influence attributes, the expected number of product adopters and the expected shared surplus, resulting from the identified product configurations and seed customers, are proved to be larger than those obtained from existing practice of viral marketing and product line design respectively, based on the case study of Kindle Fire HD tablets. Thus, the proposed paradigm of design extends the traditional boundaries among domains of engineering design, viral marketing, and social computing.

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Medwetz, Abigail. „The Effects of Color on Visual Perception and Visual Clutter“. Kent State University Honors College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1556373271322324.

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Zajaczkowski, Maciej. „Fast reactor design with enhanced Doppler Effect : Core design, computer scheme design, uncertainty evaluation“. Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALI054.

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Afin d'améliorer la sûreté passive des réacteurs rapides refroidis au sodium (SFR) en cas de transitoires non protégés, tels que la perte de débit non protégée (ULOF) ou une insertion de réactivité (UTOP), le CEA a proposé le concept CADOR - une nouvelle conception du cœur SFR avec un effet Doppler renforcé. L'une des caractéristiques de conception la plus importante est l’implantation de modérateur dans chaque assemblage combustible pour diminuer l'énergie moyenne des neutrons d'environ 40%. La solution conduit à un effet Doppler environ trois fois plus élevé en raison de l'augmentation de la population de neutrons dans les résonances. D'autre part, le spectre neutronique adouci modifie d'autres propriétés du cœur. Par exemple, le placement hétérogène du modérateur dans l'assemblage peut entraîner une distribution inégale de la vitesse de réaction et un risque de pics de puissance non observés dans les SFR standard. Pour démontrer la sûreté du concept CADOR, il est essentiel d'évaluer d'abord la fiabilité des outils de calcul, à la suite d'un processus de vérification, validation et quantification d'incertitude (VVQI). Les modifications du bilan neutronique remettent en question l'applicabilité des schémas de calcul standards du transport neutronique dans le cadre de ce concept CADOR. Par conséquent, le but de cette thèse est d'établir un schéma de calcul de neutronique précis, conforme aux principes de la VVQI, prenant en compte tous les phénomènes physiques pertinents liés aux propriétés atypiques de CADOR.Un schéma de calcul du code neutronique déterministe APOLLO3 a été défini comme base de l'analyse. Les cœurs CADOR avec deux types de modérateurs différents, beryllium (Be) et hydrure de zirconium (ZrH2), ont été utilisés. Les éléments du schéma et leurs améliorations possibles ont été étudiés par comparaison directe avec le code Monte Carlo de référence TRIPOLI-4. Les biais systématiques des modèles numériques (différentes approches d'homogénéisation spatiale ou de traitement de résonance ascendante, différentes définitions d'énergie et de maillage spatial) ont été étudiés pour la précision de keff, l'effet Doppler et les taux de réactions. Les sources d'incertitudes les plus importantes ont été identifiées et quantifiées. Enfin, comme première estimation de la sensibilité du schéma de calcul multi-physique, l'impact des incertitudes sur les simulations des transitoires UTOP et ULOF a été évalué par couplage avec MACARENa, un code de calcul pour l'analyse transitoire en SFR.Les résultats indiquent que la précision du schéma de calcul peut être améliorée en appliquant un traitement de diffusion exact, notamment en cas de cœur avec ZrH2 où l'utilisation d'un modelé de diffusion simplifié conduit à une sous-estimation de l'effet Doppler jusqu'à 5,2%. Avec un traitement de diffusion exact, le biais global du schéma de calcul d'APOLLO3 a été estimé à environ 500 pcm pour le cœur avec le modérateur Be et 460 pcm pour le cœur avec le modérateur ZrH2. Les biais dans le cas de CADOR sont du même ordre de grandeur que pour les cœurs SFR conventionnels. En conservant une description plus hétérogène de la zone fissile pendant le processus d'homogénéisation, le biais global peut être encore réduit de 110-280 pcm en fonction du niveau d'hétérogénéité étudié ; cependant, cette approche présente l'inconvénient d'une complexité de calcul nettement plus élevée. L'analyse de sensibilité réalisée dans MACARENa suggère que les incertitudes des calculs neutroniques ont un impact mineur sur la progression des transitoires simulés. Ce travail montre que les méthodes disponibles dans APOLLO3 fournissent une bonne précision de calcul des SFR, même dans le cas de conceptions moins conventionnelles. Les faibles incertitudes du schéma de calcul indiquent la robustesse des modèles numériques utilisés; le schéma de calcul offre une précision suffisante pour être appliqué dans la conception des réacteurs rapides et leurs études de sûreté
In order to improve passive safety of Sodium-cooled Fast Reactors (SFR) in case of unprotected transients such as Unprotected Loss of Flow (ULOF) or Unprotected Transient Overpower (UTOP), The French Alternative Energies and Atomic Energy Commission proposed a CADOR concept – a new design of SFR core with enhanced Doppler effect. One of the most important design features is the addition of moderating materials inside fuel assemblies to decrease the average neutron energy by around 40%. The solution leads to roughly three times higher magnitude of Doppler effect due to the increase of resonance neutron population. On the other hand, the softened neutron spectrum changes other core properties. It increases the importance of low-energy neutron scattering and absorption. Moreover, the heterogeneous moderator placement in the assembly may cause an uneven reaction rate distribution and a risk of power peaks not observed in standard SFRs. To demonstrate the safety of CADOR design, it is essential to first evaluate the performance of calculation tools following a Verification, Validation and Uncertainty Quantification (VVUQ) - a process that must be applied to calculation codes and methods to show their reliability. The aforementioned changes in the neutron balance put into question the applicability of standard fast reactor neutronic calculation schemes to the case of CADOR. The purpose of this thesis, therefore, is to establish an accurate neutron transport calculation scheme, in line with VVUQ principles, that takes into account all relevant physical phenomena related to atypical properties of the CADOR core.A two-step calculation scheme of deterministic neutron transport code APOLLO3 was defined as a basis for the analysis. The CADOR cores with two different moderator types, Be and ZrH2, were used. The elements of the scheme and their possible improvements were studied through direct comparison with the reference Monte Carlo code TRIPOLI-4. The systematic biases of numerical models, such as: different spatial homogenization approaches or resonance upscattering treatment, different energy and spatial mesh definitions, were studied with respect to accuracy of multiplication factor, Doppler effect and reaction rates. The most important sources of uncertainties were identified and quantified. Finally, as a first estimation of the sensitivity of the multiphysics calculation scheme, the impact of the uncertainties on simulations UTOP and ULOF transients was evaluated via coupling with MACARENa, a calculation code for transient analysis in SFRs.The results indicate that the accuracy of calculation scheme can be improved by applying exact scattering treatment, notably in case of core with ZrH2 moderator where utilization of simplified scattering kernel leads to underestimation of Doppler effect of up to 5.2 %. With exact scattering treatment the global bias of the calculation scheme of APOLLO3 was estimated at approximately 500 pcm for core with Be moderator and 460 pcm for core with ZrH2 moderator. The biases in case of CADOR are of the same order of magnitude as for conventional SFR designs. By preserving more heterogeneous description of the fissile zone during homogenization process the global bias can be further reduced by 110-280 pcm depending on the studied level of heterogeneity; however this approach has a drawback of significantly higher computational complexity. The sensitivity analysis performed in MACARENa suggests that the uncertainties of neutronic calculations have minor impact on the progression of simulated transients. This work shows that the methods available in APOLLO3 provide a good accuracy of calculation of SFRs, even in case of less conventional designs. The low uncertainties of the calculation scheme indicate robustness of the numerical models used; the calculation scheme provides sufficient accuracy to be applied in fast reactor design and safety studies

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Kennedy, John Anthony. „Analytical and experimental evaluation of steel sheets for blast retrofit design“. Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/5849.

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Thesis (M.S.)--University of Missouri-Columbia, 2005.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (January 24, 2007) Includes bibliographical references.

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Karaca, Ece. „Interactive Data Visualization: Applications Used to Illuminate the Environmental Effects of the Syrian War“. The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524096815846145.

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Rundqvist, Konrad. „Side effects of level dependent hearing protectors“. Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-82150.

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Hearing protectors are used in noisy environments to attenuate damaging soundlevels. Problems are reported to arise from using hearing protectors, since usefulsounds also are attenuated. Not only are sound levels attenuated, but other humanabilities are affected by hearing protectors, such as the ability to identify and localizesounds. Manufacturers of hearing protectors also develop level-dependent hearingprotectors that are supposed to create a better listening experience for the user thandoes passive hearing protectors. This thesis investigates how the ability to identifysound is affected by hearing protectors in the Swedish processing industry and towhat extent level-dependent hearing protectors improve the user’s ability to identifysound. Semi-structured interviews were conducted by asking questions based on theprojects research questions and theories found from a literary study. A questionnairewas sent out with similar questions for verification purposes. The current literatureshows that the human ability to identify sound deteriorates by the occlusion from hearing protectors. Indications are such that hearing protectors with a level-dependent function deteriorate the ability less than does passive protectors. The relevance of this in the processing industry does not seem to be very palpable. Usersindicate that it would be dangerous for this ability to be deteriorated in theworkplace and that level-dependent hearing protectors does a better job apreserving sound identification than passive protectors, but their soundidentification ability is not deteriorated enough by passive hearing protectors forproblems to arise.

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Yang, Shaoguang. „Design and Investigation of Polyurethane End-Capped Polyesters with Controlled Hydrolytic Stability“. University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1407971721.

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Rahman, Mohammad. „Estimation of treatment effects using Regression Discontinuity design“. Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/estimation-of-treatment-effects-using-regression-discontinuity-design(b838592f-7648-4119-8e73-a299fddfda5f).html.

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This thesis includes three substantive empirical studies (in Chapters 3, 4 and 5), where each study uses the same econometric methodology, named Regression Discontinuity design, which has an attractive feature - local randomisation. This feature has given the superiority of the method over the other evaluation methods in estimating unbiased treatment effects. Besides, the fuzzy Regression Discontinuity design can control for the endogeneity of the treatment variable, which is another advantage of the method. In each of the studies considered, the endogeneity problem exists. The application of the fuzzy Regression Discontinuity design is itself a contribution in each of the studies. Moreover, each study contributes in its own field. In Chapter 3, we investigate how much the Social Safety Net programs, that provide free food, or cash, or both to the food insecure households in Bangladesh, improve calorie consumption of the beneficiary households. Using Household Income and Expenditure Survey 2005, we find that the effect of the programs is around 843 kilo calorie, which is substantial compared to the previous studies. In Chapter 4, we examine how much was the impact of Education Maintenance Allowance, a program that provided weekly allowance to the young people in Years 12 and 13 in England, on the staying rate in the post compulsory full-time education. The program was abolished in 2010. Using the Longitudinal Survey of Young People in England, we find that the effect of the program was substantial - around 15 percent. The effect of a £1 increase in weekly allowance was around 1 percent. These effects were mainly on the white young people. Using the household survey data - Family Expenditure Survey (1968-2009) - in UK, Chapter 5 establishes that before 1981 consumption substantially fell at the retirement age. This fall is less severe after 1980. However, throughout the data period, consumption fall at the retirement age is fully explained by the expected fall in income, which contradicts the life cycle model, where a consumption growth is independent of an income growth.

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Corzine, Elizabeth. „Standards-based grading| Effects on classroom instruction“. Thesis, McKendree University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10190457.

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The purpose of this study was to determine if the implementation of a standards-based grading system has an effect on classroom instruction. In particular, how does the implementation of a standards-based grading system impact the teaching methods, curriculum, differentiation, and formative assessments being used in classrooms? The researcher identified five schools in the Southern Illinois area that have adopted the standards-based grading system and chose eleven teachers to participate in this study through purposeful convenience sampling. This study used a phenomenological qualitative approach. There were two methods used in order to collect data including face to face interviews and document analysis. The findings of this study are significant to any district who is considering changing their grading system from a traditional grading system to a standards-based grading system. Through six major themes that emerged, this study shows that by switching to a standards-based grading system multiple parts of the classroom are impacted including the teaching methods, content, differentiation, and formative assessments. The six major themes included: teaching methods have been modified to better adjust to the standards-based grading system and include a larger variety of approaches, teaching methods are more of a response to student need than a pre-planned approach to teaching, the curriculum and content being taught in the classroom have better alignment to the standards, teachers have a greater awareness of both the curriculum and standards that are being taught at their grade level, as well as at other grade level, teachers have a better understanding of the individual needs of students and have used differentiation to meet these unique needs, and the use of formative assessments have increased in order to adjust for more fluid groupings being used in the classroom.

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Lewandowski, Craig Michael. „Design and evaluation of end-effectors for autonomous sampling“. College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8760.

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Thesis (M.S.) -- University of Maryland, College Park, 2008.
Thesis research directed by: Dept. of Aerospace Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Shen, Jian. „Double gate MOSFETs : process variations and design considerations /“. View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?ELEC%202005%20SHEN.

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Kanuka, Heather Anne. „Screen design, effects of design principles on recall learning and study time“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq21240.pdf.

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Najafizadeh, Laleh. „Design of analog circuits for extreme environment applications“. Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31796.

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Thesis (Ph.D)--Electrical and Computer Engineering, Georgia Institute of Technology, 2010.
Committee Chair: Cressler, John; Committee Member: Papapolymerou, John; Committee Member: Shen, Shyh-Chiang; Committee Member: Steffes, Paul; Committee Member: Zhou, Hao Min. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Dissertationen zum Thema „Effector design“

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